GCF_009676565.1 - 8 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP040438.1 (Stenotrophomonas maltophilia)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	RiPP-like	1,288,426	1,299,271
Region 2	RiPP-like	1,571,314	1,582,189
Region 3	lanthipeptide-class-ii	1,787,615	1,810,512
Region 4	lassopeptide	2,486,102	2,508,656
Region 5	NRP-metallophore,NRPS	2,704,827	2,753,194	High	2,3-dihydroxybenzoylserine	NRPS:Type I
Region 6	terpene-precursor	3,330,816	3,351,694
Region 7	NRPS,T1PKS,NRPS-like	3,361,873	3,455,938
Region 8	arylpolyene	4,584,293	4,627,895	Low	APE Vf	other:other

NZ_CP040438.1 - Region 1 - RiPP-like

Download region GenBank file

Download region SVG

Location: 1,288,426 - 1,299,271 nt. (total: 10,846 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000043.5	0.37	PKS	curacin A	Moorea producens 19L
BGC0001484.3	0.33	other (other)	2'-chloropentostatin, 2'-amino-2'-deoxyadenosine	Actinomadura sp. ATCC 39365
BGC0002000.4	0.32	PKS	setomimycin	Streptomyces aurantiacus JA 4570
BGC0000527.5	0.31	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0002571.2	0.31	NRPS	pyoverdine DC3000	Pseudomonas syringae pv. tomato str. DC3000
BGC0001789.3	0.31	ribosomal	suicin 90-1330	Streptococcus suis
BGC0000536.3	0.31	ribosomal	nisin Q	Lactococcus lactis
BGC0000535.4	0.31	ribosomal	nisin A	Lactococcus lactis subsp. lactis
BGC0000537.3	0.31	ribosomal	nisin U	Streptococcus uberis
BGC0002047.2	0.30	PKS	brasiliquinone A, brasiliquinone B	Nocardia brasiliensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000043.5	0.37	PKS	curacin A	Moorea producens 19L
BGC0001484.3	0.33	other (other)	2'-chloropentostatin, 2'-amino-2'-deoxyadenosine	Actinomadura sp. ATCC 39365
BGC0002000.4	0.32	PKS	setomimycin	Streptomyces aurantiacus JA 4570
BGC0000527.5	0.31	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0002571.2	0.31	NRPS	pyoverdine DC3000	Pseudomonas syringae pv. tomato str. DC3000
BGC0001789.3	0.31	ribosomal	suicin 90-1330	Streptococcus suis
BGC0000536.3	0.31	ribosomal	nisin Q	Lactococcus lactis
BGC0000535.4	0.31	ribosomal	nisin A	Lactococcus lactis subsp. lactis
BGC0000537.3	0.31	ribosomal	nisin U	Streptococcus uberis
BGC0002047.2	0.30	PKS	brasiliquinone A, brasiliquinone B	Nocardia brasiliensis

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.77 out of 23.79

Confidence: medium

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 19.02 out of 21.84

Confidence: medium

TFBS Finder

TFBS definitions

Regulator	Description
IolR	Regulator of the inositol catabolism
MexT	Global virulence regulator

NZ_CP040438.1 - Region 2 - RiPP-like

Download region GenBank file

Download region SVG

Location: 1,571,314 - 1,582,189 nt. (total: 10,876 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001962.3	0.27	PKS	hierridin B, hierridin C	Cyanobium sp. LEGE 06113
BGC0000188.5	0.23	other (other)	saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2	Cylindrospermopsis raciborskii T3
BGC0001650.4	0.23	NRPS	Le-pyrrolopyrazines	Lysobacter enzymogenes
BGC0000452.5	0.20	NRPS	tyrocidine	Brevibacillus brevis NBRC 100599
BGC0000651.5	0.20	terpene	KS-505a	Streptomyces argenteolus
BGC0001283.3	0.18	PKS	Bisenarsan	Streptomyces lividans 1326

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001962.3	0.27	PKS	hierridin B, hierridin C	Cyanobium sp. LEGE 06113
BGC0000188.5	0.23	other (other)	saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2	Cylindrospermopsis raciborskii T3
BGC0001650.4	0.23	NRPS	Le-pyrrolopyrazines	Lysobacter enzymogenes
BGC0000452.5	0.20	NRPS	tyrocidine	Brevibacillus brevis NBRC 100599
BGC0000651.5	0.20	terpene	KS-505a	Streptomyces argenteolus
BGC0001283.3	0.18	PKS	Bisenarsan	Streptomyces lividans 1326

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.19 out of 19.26

Confidence: medium

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.64 out of 26.85

Confidence: medium

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.74 out of 20.47

Confidence: medium

Additional weak hits (1):

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.06 out of 26.33

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
RutR	Regulator of the pyrimidine and purine metabolism
VqsM	Regulator of quorum-sensing signalling systems

NZ_CP040438.1 - Region 3 - lanthipeptide-class-ii

Download region GenBank file

Download region SVG

Location: 1,787,615 - 1,810,512 nt. (total: 22,898 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: cyclase

FEO89_RS08355: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000528.5	0.52	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0002703.2	0.49	ribosomal	archalan α	Halorussus salinus
BGC0000554.4	0.48	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0002346.3	0.47	ribosomal	kyamicin	Saccharopolyspora sp.
BGC0000503.5	0.46	ribosomal	cinnamycin	Streptomyces cinnamoneus
BGC0001579.4	0.46	ribosomal	duramycin	Streptomyces cinnamoneus
BGC0002698.2	0.43	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0001576.3	0.43	ribosomal	divamide A	Prochloron didemni
BGC0000500.5	0.41	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0002316.2	0.41	ribosomal	cebulantin	Saccharopolyspora cebuensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000528.5	0.52	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0002703.2	0.49	ribosomal	archalan α	Halorussus salinus
BGC0000554.4	0.48	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0002346.3	0.47	ribosomal	kyamicin	Saccharopolyspora sp.
BGC0000503.5	0.46	ribosomal	cinnamycin	Streptomyces cinnamoneus
BGC0001579.4	0.46	ribosomal	duramycin	Streptomyces cinnamoneus
BGC0002698.2	0.43	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0001576.3	0.43	ribosomal	divamide A	Prochloron didemni
BGC0000500.5	0.41	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0002316.2	0.41	ribosomal	cebulantin	Saccharopolyspora cebuensis

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for FEO89_RS08355

FEO89_RS08350

Leader:

MDLNDDVVSGWLNGSDDVDGCANPAGSLFIYGA

Core:

AATESALTSASDTLITGGGTECTTTMSVVNHCLCC

Core with dehydrations:

AADhbEDhaALDhbDhaADhaDDhbLIDhbGGGDhbECysDhbDhbDhbMDhaVVNHCysLCysCys

antiSMASH-DB 4.0 matches for FEO89_RS08350

100.0%

NZ_CP015612.1and 17 others:

NZ_CP027562.1 Lanthipeptides: C6Y55_RS08375_lanthipeptideNZ_CP028358.1 Lanthipeptides: C9J74_RS08630_lanthipeptideNZ_CP040435.1 Lanthipeptides: FEO92_RS08800_lanthipeptideNZ_CP040438.1 Lanthipeptides: FEO89_RS08350_lanthipeptideNZ_CP040439.1 Lanthipeptides: FEO88_RS08780_lanthipeptideNZ_CP056088.1 Lanthipeptides: HUZ96_RS08220_lanthipeptideNZ_CP090418.1 Lanthipeptides: LYZ64_RS08310_lanthipeptideNZ_CP109812.1 Lanthipeptides: FQS62_RS08595_lanthipeptideNZ_DS999412.1 Lanthipeptides: SSKA14_RS15505_lanthipeptideNZ_JAEDUZ010000008.1 Lanthipeptides: JAK52_RS03215_lanthipeptideNZ_JAEDWK010000010.1 Lanthipeptides: JAK51_RS04155_lanthipeptideNZ_JAJNMF010000022.1 Lanthipeptides: LQ423_RS11465_lanthipeptideNZ_JVUI01000059.1 Lanthipeptides: ADG58_RS15825_lanthipeptideNZ_LR134301.1 Lanthipeptides: EL200_RS07985_lanthipeptideNZ_OBEE01000002.1 Lanthipeptides: CRO53_RS02030_lanthipeptideNZ_RHQE01000015.1 Lanthipeptides: EGJ89_RS13150_lanthipeptideNZ_SOCO01000001.1 Lanthipeptides: N440_RS05690_lanthipeptide

Lanthipeptides: A7326_RS08120_lanthipeptide

1

AATESALTSASDTLITGGGTECTTTMSVVNHCLCC

35

AATESALTSASDTLITGGGTECTTTMSVVNHCLCC

1

AATESALTSASDTLITGGGTECTTTMSVVNHCLCC

35

97.1%

NZ_CP011010.1:

Lanthipeptides: VN11_RS08230_lanthipeptide

1

AATESALTSASDTLITGGGTECTTTMSVVNHCLCC

35

AATESALT+ASDTLITGGGTECTTTMSVVNHCLCC

1

AATESALTAASDTLITGGGTECTTTMSVVNHCLCC

35

97.1%

NZ_CP043578.1and 3 others:

NZ_CP067993.1 Lanthipeptides: JJL50_RS07700_lanthipeptideNZ_JVHP01000063.1 Lanthipeptides: ADI44_RS21105_lanthipeptideNZ_OU943334.1 Lanthipeptides: LNN95_RS09005_lanthipeptide

Lanthipeptides: F0Q13_RS08255_lanthipeptide

1

AATESALTSASDTLITGGGTECTTTMSVVNHCLCC

35

ATESALTSASDTLITGGGTECTTTMSVVNHCLCC

1

GATESALTSASDTLITGGGTECTTTMSVVNHCLCC

35

with 16 more sequence matches

Only the first 10 are displayed here.

72.3%

NZ_CP047310.1and 4 others:

NZ_CP104169.1 Lanthipeptides: NDR96_RS06465_lanthipeptideNZ_JABDRV010000001.1 Lanthipeptides: HRL60_RS01085_lanthipeptideNZ_JAEDVS010000025.1 Lanthipeptides: JAK50_RS15965_lanthipeptideNZ_JVPM01000038.1 Lanthipeptides: ADH50_RS19075_lanthipeptide

Lanthipeptides: GS396_RS07720_lanthipeptide

2

ATESALTSASDTLITGGGTECTTTMSVVNHCLCC

35

ATESALTSASDTLITGGGTECTTTMSVVNHCLCC

14

ATESALTSASDTLITGGGTECTTTMSVVNHCLCC

47

37.1%

NZ_CP011305.1and 19 others:

NZ_CP031058.1 Lanthipeptides: DUW70_RS15590_lanthipeptideNZ_CP031167.1 Lanthipeptides: MG068_RS07815_lanthipeptideNZ_CP040436.1 Lanthipeptides: FEO91_RS08085_lanthipeptideNZ_CP046588.1 Lanthipeptides: GOC52_RS08100_lanthipeptideNZ_CP060259.1 Lanthipeptides: H7F32_RS08235_lanthipeptideNZ_CP071784.1 Lanthipeptides: J3U96_RS13765_lanthipeptideNZ_CP077679.1 Lanthipeptides: KS456_RS07940_lanthipeptideNZ_CP096975.1 Lanthipeptides: M1L61_RS08375_lanthipeptideNZ_CP104071.1 Lanthipeptides: K7565_RS07800_lanthipeptideNZ_CP104287.1 Lanthipeptides: K7567_RS07875_lanthipeptideNZ_CP104324.1 Lanthipeptides: K7569_RS08320_lanthipeptideNZ_JACLBK010000002.1 Lanthipeptides: ID844_RS05155_lanthipeptideNZ_JAEDVP010000027.1 Lanthipeptides: JAK38_RS15550_lanthipeptideNZ_JAEDVW010000007.1 Lanthipeptides: JAK53_RS03160_lanthipeptideNZ_JAEDWD010000009.1 Lanthipeptides: JAK45_RS02000_lanthipeptideNZ_JAFLWT010000006.1 Lanthipeptides: J1F00_RS06425_lanthipeptideNZ_JAQQGI010000014.1 Lanthipeptides: PQS91_RS16925_lanthipeptideNZ_KB907502.1 Lanthipeptides: G370_RS0114170_lanthipeptideNZ_RHPZ01000014.1 Lanthipeptides: EGJ03_RS16365_lanthipeptide

Lanthipeptides: YH67_RS07965_lanthipeptide

21

ECTTTMSVVNHCLCC

35

ECTTT+SV+NHCLCC

3

ECTTTVSVINHCLCC

17

36.2%

NZ_CP007597.1:

Lanthipeptides: DX03_RS09815_lanthipeptide

2

ATESALTSASDTLITGGGTECTTTMSVVNHCLCC

35

AT++ALT+ + T++TGG CTTTMSV+NHC+CC

25

ATDAALTAMAPTMVTGGTGNCTTTMSVINHCMCC

58

29.3%

NZ_CP069396.1:

Lanthipeptides: JRI60_RS03735_lanthipeptide

1

AATESALTSASDTLIT

16

AATE+ALT ASD L+T

12

AATENALTDASDALVT

27

28.8%

NZ_CP069338.1:

Lanthipeptides: JQX13_RS07220_lanthipeptide

2

ATESALTSASDTLITGGGTECTTTMSVVNHCLCC

35

ATE+ALT+++D L T G + CT ++ H CC

24

ATEAALTNSTDALYT-GCSSCTGSL----HSYCC

52

26.4%

NZ_CP093340.1:

Lanthipeptides: MNO14_RS04685_lanthipeptide

1

AATESALTSASDTLITGGGTECTT-TMSVVNHC

32

AATE+A+T S L+ T+C++ T S+ HC

24

AATEAAMTDKSFLLL----TQCSSCTASIPAHC

52

24.4%

NZ_CP029194.1and 1 other:

NZ_CP059991.1 Lanthipeptides: H4W23_RS35675_lanthipeptide

Lanthipeptides: DEJ46_RS04155_lanthipeptide

1

AATESALTSASDTLITG

17

AA E+ALT A++ L+TG

12

AAGEAALTDATEALLTG

28

24.4%

NZ_JH941044.1:

Lanthipeptides: Y19_RS0126875_lanthipeptide

1

AATESALTSASDTLITG

17

AA E+ALT A++ L TG

12

AAGEAALTDATEALFTG

28

22.9%

NZ_CP089924.1:

Lanthipeptides: LVB77_RS02735_lanthipeptide

16

TGGGTECTTTMSVVNHC

32

+G CT+ SV NHC

2

SGASVNCTSGSSVSNHC

18

22.0%

NZ_CP010407.1and 4 others:

NZ_CP010407.1 Lanthipeptides: SVTN_RS37515_lanthipeptideNZ_CP010407.1 Lanthipeptides: SVTN_RS37515_lanthipeptideNZ_CP010407.1 Lanthipeptides: SVTN_RS37515_lanthipeptideNZ_JACHJY010000017.1 Lanthipeptides: GGE06_RS39715_lanthipeptide

Lanthipeptides: SVTN_RS37515_lanthipeptide

1

AATESALTSASDTLITG

17

AA E+ALT ++ L+TG

12

AAGEAALTDGTEALLTG

28

allorf_1788723_1788908

Leader:

MDRFLNPPILEQVGPRCRRGAENGRLAGS

Core:

AAPPLATGRGLCDAAGARSPQVAAFPSQQDRP

Core with dehydrations:

AAPPLADhbGRGLCysDAAGARDhaPQVAAFPDhaQQDRP

antiSMASH-DB 4.0 matches for allorf_1788723_1788908

100.0%

NZ_CP040438.1and 1 other:

NZ_JVUI01000059.1 Lanthipeptides: allorf_007929_008114_lanthipeptide

Lanthipeptides: allorf_1788723_1788908_lanthipeptide

1

AAPPLATGRGLCDAAGARSPQVAAFPSQQDRP

32

AAPPLATGRGLCDAAGARSPQVAAFPSQQDRP

1

AAPPLATGRGLCDAAGARSPQVAAFPSQQDRP

32

28.1%

NZ_CP069338.1and 1 other:

NZ_CP069338.1 Lanthipeptides: allorf_09109175_09109414_lanthipeptide

Lanthipeptides: allorf_09109175_09109414_lanthipeptide

2

APPLATGRGLCDAAGARSP

20

APPL G C + RSP

10

APPLKEGNHPCLESFTRSP

28

23.7%

NZ_BNAV01000001.1:

Lanthipeptides: allorf_1531220_1531375_lanthipeptide

3

PPLATGRGLCDAAGARSPQVA

23

PP + RG ARSP+ A

8

PPFSLPRGRVSMLSARSPEAA

28

with 1 more sequence matches

21.9%

NZ_CP040439.1:

Lanthipeptides: allorf_1863394_1863579_lanthipeptide

26

PSQQDRP

32

PSQQDRP

26

PSQQDRP

32

allorf_1797077_1797235

Leader:

MHECPRGHAFRVVSVLRMRRIRVPAA

Core:

AQLDCASRANAVCTGGCTCHPVSLAA

Core with dehydrations:

AQLDCysADhaRANAVCysDhbGGCysDhbCysHPVDhaLAA

antiSMASH-DB 4.0 matches for allorf_1797077_1797235

100.0%

NZ_CP040438.1and 1 other:

NZ_JVUI01000059.1 Lanthipeptides: allorf_017163_017279_lanthipeptide

Lanthipeptides: allorf_1797077_1797235_lanthipeptide

1

AQLDCASRANAVCTGGCTCHPVSLAA

26

AQLDCASRANAVCTGGCTCHPVSLAA

1

AQLDCASRANAVCTGGCTCHPVSLAA

26

69.2%

NZ_CP040436.1and 8 others:

NZ_CP071784.1 Lanthipeptides: allorf_3040363_3040476_lanthipeptideNZ_CP104071.1 Lanthipeptides: allorf_1671217_1671393_lanthipeptideNZ_CP104287.1 Lanthipeptides: allorf_1684276_1684389_lanthipeptideNZ_CP104324.1 Lanthipeptides: allorf_1768103_1768216_lanthipeptideNZ_JACLBK010000002.1 Lanthipeptides: allorf_262851_262964_lanthipeptideNZ_JAEDWD010000009.1 Lanthipeptides: allorf_029791_029967_lanthipeptideNZ_JAFLWT010000006.1 Lanthipeptides: allorf_148855_148968_lanthipeptideNZ_KB907502.1 Lanthipeptides: allorf_016175_016288_lanthipeptide

Lanthipeptides: allorf_1728172_1728348_lanthipeptide

8

RANAVCTGGCTCHPVSLAA

26

RANAVC GGCTCHPVSLAA

2

RANAVCMGGCTCHPVSLAA

20

38.5%

NZ_CP040439.1:

Lanthipeptides: allorf_1871764_1871973_lanthipeptide

17

CTCHPVSLAA

26

CTCHPVSLAA

1

CTCHPVSLAA

10

with 7 more sequence matches

34.6%

NZ_CP011010.1and 3 others:

NZ_DS999412.1 Lanthipeptides: allorf_3459447_3459623_lanthipeptideNZ_JAJNMF010000022.1 Lanthipeptides: allorf_02257_02373_lanthipeptideNZ_SOCO01000001.1 Lanthipeptides: allorf_1184819_1184995_lanthipeptide

Lanthipeptides: allorf_1772540_1772716_lanthipeptide

18

TCHPVSLAA

26

TCHPVSLAA

2

TCHPVSLAA

10

34.6%

NZ_CP045572.1:

Lanthipeptides: GBF35_RS40730_lanthipeptide

4

DCASRANAVCTGGCTCHPVSLA

25

+C +N VC C HP S A

1

ECDRWSNCVCITVCATHPWSCA

22

26.9%

NZ_KZ857173.1:

Lanthipeptides: allorf_735160_735279_lanthipeptide

4

DCASRANAVCTGGCTCHPVS

23

+ A R ++C+ T HP S

4

NAAQRWGSLCSPQPTHHPAS

23

20.7%

NZ_KB893359.1:

Lanthipeptides: B154_RS0121400_lanthipeptide

2

QLDCASRANAVCT

14

LDC+ N +CT

3

NLDCSVTLNTLCT

15

20.6%

NZ_JALGRO010000002.1and 1 other:

NZ_SNVW01000005.1 Lanthipeptides: EDF64_RS09155_lanthipeptide

Lanthipeptides: MT346_RS01980_lanthipeptide

10

NAVCTGGCT

18

A CTGGCT

20

TAACTGGCT

28

18.0%

NZ_AUAX01000004.1:

Lanthipeptides: allorf_225147_225329_lanthipeptide

5

CASRANAVCTGGCTCHPVS

23

C R AV G CT PV+

2

CPGRCGAVRRGRCTWWPVT

20

15.0%

NZ_RHQE01000015.1:

Lanthipeptides: allorf_086168_086377_lanthipeptide

8

RANAVCTGGCTCHPVSLAA

26

RA+ +C G C PVS A

2

RADRLCRGRCKYVPVSSVA

20

MIBiG 4.0 matches for allorf_1797077_1797235

23.1%

BGC0001155.5 (AGY49587.1):

Thiopeptide: GE2270

10

NAVCTGGCTCHP

21

N VC C+C P

3

NCVCGFCCSCSP

14

17.9%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

11

AVCTGGCTCHP

21

A CT C P

15

AYCTLTVECMP

25

11.8%

BGC0000535.4 (ADJ56352.1):

Lanthipeptide: nisin A

11

AVCTGGC

17

++CT GC

5

SLCTPGC

11

with 1 more sequence matches

10.3%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

13

CTGGCTCHP

21

CT C P

28

CTLSKECQP

36

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.16 out of 18.16

Confidence: strong

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 21.78 out of 29.72

Confidence: medium

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 27.95 out of 32.74

Confidence: medium

Additional weak hits (4):

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 18.42 out of 25.88

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 21.46 out of 32.74

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 19.59 out of 36.54

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.79 out of 29.65

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

FEO89_RS08350 - Class II

Cleavage pHMM score: -6.70

RODEO score: 0

Monoisotopic mass: 3231.5 Da

Molecular weight: 3233.6 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3251.6 Da N = 1; 3269.6 Da N = 2; 3287.7 Da N = 3; 3305.7 Da N = 4; 3323.7 Da N = 5; 3341.7 Da N = 6; 3359.7 Da N = 7; 3377.8 Da N = 8

allorf_1788723_1788908 - Class II

Cleavage pHMM score: -3.20

RODEO score: 0

Monoisotopic mass: 3121.6 Da

Molecular weight: 3123.4 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 3141.5 Da N = 1; 3159.5 Da N = 2

allorf_1797077_1797235 - Class II

Cleavage pHMM score: -6.30

RODEO score: 0

Monoisotopic mass: 2446.1 Da

Molecular weight: 2447.8 Da

Number of bridges: 4

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
FuR variant 2	Ferric Uptake Regulator
NtrC	Nitrogen regulatory protein C

NZ_CP040438.1 - Region 4 - lassopeptide

Download region GenBank file

Download region SVG

Location: 2,486,102 - 2,508,656 nt. (total: 22,555 nt) Show pHMM detection rules used

lassopeptide: (PF13471 and Asn_synthase or micJ25 or mcjC)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lasso peptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: hydrolase

FEO89_RS11580: asparagine synthase (glutamine-hydrolyzing)

smcogs: SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

FEO89_RS11610: alpha/beta hydrolase fold protein

smcogs: SMCOG1036: alpha/beta hydrolase fold protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000577.3	0.55	ribosomal	sphingonodin II	Sphingobium japonicum UT26S
BGC0001786.3	0.52	ribosomal	subterisin	Novosphingobium subterraneum
BGC0000580.3	0.51	ribosomal	xanthomonin II, xanthomonin I	Xanthomonas gardneri ATCC 19865
BGC0000576.3	0.51	ribosomal	rubrivinodin	Rubrivivax gelatinosus IL144
BGC0000573.3	0.50	ribosomal	caulonodin I, caulonodin II	Caulobacter sp. K31
BGC0001779.5	0.46	ribosomal	siamycin	Streptomyces nodosus
BGC0000623.3	0.43	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0002015.4	0.42	ribosomal	aborycin	Streptomyces sp. ZS0098
BGC0002307.3	0.42	ribosomal	humidimycin	Streptomyces humidus
BGC0000552.3	0.41	ribosomal	SmbA, SmbB	Streptococcus mutans

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000577.3	0.55	ribosomal	sphingonodin II	Sphingobium japonicum UT26S
BGC0001786.3	0.52	ribosomal	subterisin	Novosphingobium subterraneum
BGC0000580.3	0.51	ribosomal	xanthomonin II, xanthomonin I	Xanthomonas gardneri ATCC 19865
BGC0000576.3	0.51	ribosomal	rubrivinodin	Rubrivivax gelatinosus IL144
BGC0000573.3	0.50	ribosomal	caulonodin I, caulonodin II	Caulobacter sp. K31
BGC0001779.5	0.46	ribosomal	siamycin	Streptomyces nodosus
BGC0000623.3	0.43	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0002015.4	0.42	ribosomal	aborycin	Streptomyces sp. ZS0098
BGC0002307.3	0.42	ribosomal	humidimycin	Streptomyces humidus
BGC0000552.3	0.41	ribosomal	SmbA, SmbB	Streptococcus mutans

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lasso peptide predictions

Lassopeptide(s) for FEO89_RS21625

FEO89_RS21625

Leader:

MNELIELGVVAGQQNPEDQGVGGELIELGSVVSETK

Full core:

AHNHGTLWDGVFPTTSP

Putative macrolactam:

AHNHGTLWD

antiSMASH-DB 4.0 matches for FEO89_RS21625

100.0%

NC_011071.1and 41 others:

NZ_AP021867.1 Lassopeptides: GJU96_RS20605_lassopeptideNZ_CP011010.1 Lassopeptides: VN11_RS22530_lassopeptideNZ_CP011305.1 Lassopeptides: YH67_RS21020_lassopeptideNZ_CP015612.1 Lassopeptides: A7326_RS21600_lassopeptideNZ_CP027562.1 Lassopeptides: C6Y55_RS23185_lassopeptideNZ_CP029773.1 Lassopeptides: DM611_RS22725_lassopeptideNZ_CP031058.1 Lassopeptides: DUW70_RS11975_lassopeptideNZ_CP031167.1 Lassopeptides: MG068_RS21080_lassopeptideNZ_CP037858.1 Lassopeptides: EZ304_RS20935_lassopeptideNZ_CP040432.1 Lassopeptides: FEO95_RS22840_lassopeptideNZ_CP040438.1 Lassopeptides: FEO89_RS21625_lassopeptideNZ_CP040439.1 Lassopeptides: FEO88_RS23220_lassopeptideNZ_CP043578.1 Lassopeptides: F0Q13_RS11365_lassopeptideNZ_CP046588.1 Lassopeptides: GOC52_RS10870_lassopeptideNZ_CP047310.1 Lassopeptides: GS396_RS20180_lassopeptideNZ_CP060259.1 Lassopeptides: H7F32_RS11180_lassopeptideNZ_CP067993.1 Lassopeptides: JJL50_RS10815_lassopeptideNZ_CP077679.1 Lassopeptides: KS456_RS10490_lassopeptideNZ_CP080573.1 Lassopeptides: K1516_RS11235_lassopeptideNZ_CP090418.1 Lassopeptides: LYZ64_RS11980_lassopeptideNZ_CP096975.1 Lassopeptides: M1L61_RS12085_lassopeptideNZ_CP104169.1 Lassopeptides: NDR96_RS09175_lassopeptideNZ_CP106759.1 Lassopeptides: N8888_RS09665_lassopeptideNZ_CP120400.1 Lassopeptides: PVE91_RS09960_lassopeptideNZ_JABDRV010000002.1 Lassopeptides: HRL60_RS08285_lassopeptideNZ_JADCQA010000003.1 Lassopeptides: IMX13_RS03920_lassopeptideNZ_JAEDVS010000016.1 Lassopeptides: JAK50_RS09365_lassopeptideNZ_JAEDVW010000040.1 Lassopeptides: JAK53_RS10000_lassopeptideNZ_JAEDWA010000005.1 Lassopeptides: JAK63_RS01795_lassopeptideNZ_JAEDWK010000019.1 Lassopeptides: JAK51_RS11395_lassopeptideNZ_JAEDWU010000002.1 Lassopeptides: JAK37_RS06750_lassopeptideNZ_JAKJQX010000001.1 Lassopeptides: MT466_RS00850_lassopeptideNZ_JAQQGI010000001.1 Lassopeptides: PQS91_RS01155_lassopeptideNZ_JVHP01000037.1 Lassopeptides: ADI44_RS25485_lassopeptideNZ_JVPM01000019.1 Lassopeptides: ADH50_RS20965_lassopeptideNZ_JVUI01000038.1 Lassopeptides: ADG58_RS23065_lassopeptideNZ_OBEE01000001.1 Lassopeptides: CRO53_RS21815_lassopeptideNZ_OU943334.1 Lassopeptides: LNN95_RS11880_lassopeptideNZ_RHPZ01000001.1 Lassopeptides: EGJ03_RS21120_lassopeptideNZ_RHQE01000001.1 Lassopeptides: EGJ89_RS22430_lassopeptideNZ_SOCO01000001.1 Lassopeptides: N440_RS20340_lassopeptide

Lassopeptides: SMAL_RS21110_lassopeptide

1

AHNHGTLWDGVFPTTSP

17

AHNHGTLWDGVFPTTSP

1

AHNHGTLWDGVFPTTSP

17

88.2%

NZ_CP058243.1:

Lassopeptides: AD14011_RS10295_lassopeptide

1

AHNHGTLWDGVFPTTSP

17

AH HGTLWDG+FPTTSP

1

AHGHGTLWDGIFPTTSP

17

61.1%

NZ_CP049017.1:

Lassopeptides: G4Q83_RS07645_lassopeptide

1

AHNHGTLWDGVF-PTTSP

17

AHNHGT + F TTSP

1

AHNHGTFLEASFIATTSP

18

with 5 more sequence matches

29.2%

NZ_CP033362.1:

Lassopeptides: EB232_RS01185_lassopeptide

6

TLWDGVFPTTSP

17

T DGVFP +P

6

TALDGVFPIHTP

17

22.2%

NZ_CP044492.1and 1 other:

NZ_CP066294.2 Lanthipeptides: IGS65_RS08185_lanthipeptide

Lanthipeptides: FSA31_RS00605_lanthipeptide

8

WDGVFPTTS

16

W GV PT S

4

WQGVVPTVS

12

22.2%

NZ_CP049223.1and 4 others:

NZ_CP049225.1 Lanthipeptides: G6Z85_RS06555_lanthipeptideNZ_CP049228.1 Lanthipeptides: G6Z83_RS06555_lanthipeptideNZ_JAKWZB010000003.1 Lanthipeptides: MMO78_RS01405_lanthipeptideNZ_PNGO01000002.1 Lanthipeptides: CJ224_RS02730_lanthipeptide

Lanthipeptides: G6Z86_RS06445_lanthipeptide

8

WDGVFPTTS

16

W GV PT S

4

WQGVLPTVS

12

22.2%

NZ_FNUH01000004.1and 1 other:

NZ_FOGM01000011.1 Lanthipeptides: BMX20_RS07220_lanthipeptide

Lanthipeptides: BLU50_RS05815_lanthipeptide

7

LWDGVFPTTS

16

W GV PT S

3

FWQGVVPTVS

12

13.9%

NZ_CP015883.1and 1 other:

NZ_JAASJP010000011.1 Lanthipeptides: allorf_43013_43183_lanthipeptide

Lanthipeptides: allorf_0205278_0205448_lanthipeptide

3

NHGTLWDGVF

12

N+G +W+ VF

16

NNGCMWNTVF

25

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.73 out of 23.79

Confidence: medium

Additional weak hits (7):

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 15.39 out of 26.06

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 25.78 out of 33.14

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 26.30 out of 33.14

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 20.01 out of 33.14

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 22.10 out of 30.11

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 22.10 out of 30.11

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 19.65 out of 22.40

Confidence: weak

Lasso peptides

RREFinder

TFBS Finder

Core peptide predictions

FEO89_RS21625 - Class II: Cleavage pHMM score: 10.60; RODEO score: 22; Monoisotopic mass: 1817.8 Da; Molecular weight: 1818.9 Da; Number of bridges: 0

RRE predictions

: RRE type: Lasso_Fused_RRE; Location: 5 - 77; Score: 46.9

TFBS definitions

Regulator	Description
IolR	Regulator of the inositol catabolism

NZ_CP040438.1 - Region 5 - NRP-metallophore,NRPS

Download region GenBank file

Download region SVG

Location: 2,704,827 - 2,753,194 nt. (total: 48,368 nt) Show pHMM detection rules used

NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

FEO89_RS12600: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

FEO89_RS12640: oxidoreductase

smcogs: SMCOG1083: oxidoreductase

FEO89_RS12660: flavin reductase domain protein FMN-binding

smcogs: SMCOG1160: flavin reductase domain protein FMN-binding

Hydrolases: hydrolase

FEO89_RS12615: isochorismatase

smcogs: SMCOG1027: isochorismatase

Isomerases: isomerase

FEO89_RS12625: isochorismate synthase

smcogs: SMCOG1018: isochorismate synthase

Ligases: ligase

FEO89_RS12605: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

FEO89_RS12620: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002689.2	1.32	NRPS	2,3-dihydroxybenzoylserine	Stenotrophomonas maltophilia K279a
BGC0001132.4	0.70	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002286.3	0.69	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4	0.68	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.67	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001128.4	0.67	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.66	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001135.5	0.63	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001641.4	0.63	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000343.5	0.62	NRPS	enterobactin	Pseudomonas sp. J465

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002689.2	0.87	NRPS	2,3-dihydroxybenzoylserine	Stenotrophomonas maltophilia K279a
BGC0001132.4	0.68	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002286.3	0.67	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4	0.67	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.67	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001128.4	0.67	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.66	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001135.5	0.65	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001641.4	0.65	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000343.5	0.65	NRPS	enterobactin	Pseudomonas sp. J465

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.12 out of 23.79

Confidence: medium

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 18.67 out of 20.01

Confidence: medium

Additional weak hits (26):

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 20.44 out of 29.38

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.65 out of 32.74

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 19.23 out of 29.38

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 18.83 out of 27.78

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 19.10 out of 25.88

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.36 out of 20.01

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 15.81 out of 26.06

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.29 out of 25.75

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 19.08 out of 29.38

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 21.16 out of 32.74

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 18.59 out of 29.38

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 26.18 out of 32.74

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 20.11 out of 33.73

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 23.91 out of 30.97

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 20.98 out of 31.73

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 21.13 out of 31.73

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 27.70 out of 39.62

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.50 out of 39.62

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 18.58 out of 30.25

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 18.91 out of 29.38

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 17.56 out of 28.14

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 23.92 out of 39.62

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 27.05 out of 39.62

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 23.00 out of 33.14

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 18.10 out of 33.14

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.44 out of 32.93

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 5, location 2704826 - 2753194:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Ser)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

FEO89_RS12605: Ser

Search NORINE for peptide: strict or relaxed

AMP-binding (457..845): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: RWMTFDVSVWELHFFTSGEHNLYGPTEAAVDVSY
Nearest Stachelhaus code(s):: Ser DVWHFSLVDK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

FEO89_RS12620: diOH-Bz

Search NORINE for peptide: strict or relaxed

AMP-binding (39..444): diOH-Bz

nrpys: diOH-Bz

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Small clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Single AA prediction:: dhb (diOH-Bz)

Stachelhaus prediction details:

Stachelhaus sequence:: SASLFPMSSPGGGLQVGGAQQVFGMAEGLVNYTR
Nearest Stachelhaus code(s):: diOH-Bz PMPAQGVVNK (94% 8Å match)
Stachelhaus code match:: 90% (moderate)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
ArgR	Regulator of arginine biosynthesis genes
IolR	Regulator of the inositol catabolism

NZ_CP040438.1 - Region 6 - terpene-precursor

Download region GenBank file

Download region SVG

Location: 3,330,816 - 3,351,694 nt. (total: 20,879 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Ligases: synthetase

FEO89_RS15485: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.38	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0000643.3	0.33	terpene	carotenoid	Brevundimonas vesicularis
BGC0000640.3	0.32	terpene	carotenoid	Enterobacteriaceae bacterium DC404
BGC0000634.3	0.32	terpene	carotenoid	Brevundimonas sp. SD212
BGC0000630.3	0.31	terpene	(2R,3S,3'S)-2-hydroxyastaxanthin	Paracoccus haeundaensis
BGC0000641.3	0.30	terpene	carotenoid	Enterobacteriaceae bacterium DC416
BGC0000639.3	0.30	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000642.3	0.30	terpene	carotenoid	Enterobacteriaceae bacterium DC413

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.38	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0000643.3	0.33	terpene	carotenoid	Brevundimonas vesicularis
BGC0000640.3	0.32	terpene	carotenoid	Enterobacteriaceae bacterium DC404
BGC0000634.3	0.32	terpene	carotenoid	Brevundimonas sp. SD212
BGC0000630.3	0.31	terpene	(2R,3S,3'S)-2-hydroxyastaxanthin	Paracoccus haeundaensis
BGC0000641.3	0.30	terpene	carotenoid	Enterobacteriaceae bacterium DC416
BGC0000639.3	0.30	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000642.3	0.30	terpene	carotenoid	Enterobacteriaceae bacterium DC413

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

FEO89_RS15485: PT_FPPS_like

Domain 1 (32 - 292): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: DMAPP, IPP → FPP

Transcription Factor Binding Sites

Binding sites found:

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.13 out of 19.26

Confidence: medium

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 19.52 out of 19.52

Confidence: strong

Additional weak hits (4):

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 14.63 out of 18.57

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 14.42 out of 18.57

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 16.64 out of 21.84

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 17.56 out of 29.25

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
AfsQ1	Two-component system AfsQ1-Q2, activator of antibiotic production
CRP	Cyclic AMP receptor protein

NZ_CP040438.1 - Region 7 - NRPS,NRPS-like,T1PKS

Download region GenBank file

Download region SVG

Location: 3,361,873 - 3,455,938 nt. (total: 94,066 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

FEO89_RS15685: Dioxygenase TauD/TfdA

smcogs: SMCOG1046: Dioxygenase TauD/TfdA

FEO89_RS15725: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: PPTase acylase methyltransferase

FEO89_RS15690: methyltransferase

smcogs: SMCOG1089: methyltransferase

FEO89_RS15700: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

FEO89_RS15735: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1060: 4'-phosphopantetheinyl transferase

Hydrolases: esterase hydrolase

FEO89_RS15710: thioesterase

smcogs: SMCOG1004: thioesterase

FEO89_RS15730: thioesterase

smcogs: SMCOG1004: thioesterase

FEO89_RS15780: beta-lactamase

smcogs: SMCOG1053: beta-lactamase

Lyases: cyclase

FEO89_RS15595: diguanylate cyclase

smcogs: SMCOG1025: diguanylate cyclase

Ligases: ligase synthase

FEO89_RS15625: 3-oxoacyl-(acyl carrier protein) synthase III

smcogs: SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III

FEO89_RS15645: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

FEO89_RS15655: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

FEO89_RS15660: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

FEO89_RS15670: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

FEO89_RS15680: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

FEO89_RS15695: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

FEO89_RS15705: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

FEO89_RS15720: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	1.24	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001249.5	1.24	NRPS	dimethylcoprogen	Alternaria alternata
BGC0001128.4	1.23	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5	1.23	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001132.4	1.21	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001261.3	1.20	NRPS	AM-toxin	Alternaria alternata
BGC0002286.3	1.19	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4	1.18	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001758.4	1.17	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0000342.4	1.10	NRPS	enniatin	Fusarium equiseti

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001135.5	0.75	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001758.4	0.75	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0002135.2	0.75	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001128.4	0.74	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001249.5	0.73	NRPS	dimethylcoprogen	Alternaria alternata
BGC0001261.3	0.73	NRPS	AM-toxin	Alternaria alternata
BGC0001833.4	0.73	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001132.4	0.73	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002286.3	0.73	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001133.4	0.72	NRPS	taxlllaid A	Xenorhabdus bovienii SS-2004

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.55 out of 18.46

Confidence: strong

Additional weak hits (10):

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 23.71 out of 30.97

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 19.71 out of 30.25

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 19.14 out of 27.78

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 19.40 out of 26.12

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 19.61 out of 26.33

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 19.21 out of 26.33

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.06 out of 26.33

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 20.37 out of 36.54

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.55 out of 30.22

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 19.43 out of 33.14

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 7, location 3361872 - 3455938:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Thr) + (ohmal) + (Ser - ohmal) + (Ser - Val) + (D-Ile - X) + (Ala) + (X) + (Hpg)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 8, location 3361872 - 3450698:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Thr) + (ohmal) + (Ser - ohmal) + (Ser - Val) + (D-Ile - X) + (Ala) + (X) + (Hpg)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 9, location 3412989 - 3455938:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Thr) + (ohmal) + (Ser - ohmal) + (Ser - Val)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

FEO89_RS15645: X

AMP-binding (20..386): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LDFSQRLSVY-GVAITGMALEAYGVTETGMIAWN
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

FEO89_RS15655: Hpg

Search NORINE for peptide: strict or relaxed

AMP-binding (549..938): Hpg

nrpys: Hpg

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: HSYAFDASVLDGHSVLGGEIGLYGATESSLTTLV
Nearest Stachelhaus code(s):: Hpg DALHLGLLCK (47% 8Å match)
Stachelhaus code match:: 80% (moderate)

FEO89_RS15660: X

AMP-binding (526..928): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LHVSFDVSVYEAYVLVGVEINGYGPTETTVCCTT
Nearest Stachelhaus code(s):: Met DVFYLGGVFK (68% 8Å match)
Stachelhaus code match:: 80% (moderate)

FEO89_RS15670: Ala

Search NORINE for peptide: strict or relaxed

AMP-binding (464..853): Ala

nrpys: Ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: ala (Ala)

Stachelhaus prediction details:

Stachelhaus sequence:: FWVTFDLSVFEANTNLAGENDLYGPSEDTTYSTW
Nearest Stachelhaus code(s):: Ala DLFNNALTYK (88% 8Å match)
Stachelhaus code match:: 100% (strong)

FEO89_RS15680: Ile - X

Search NORINE for peptide: strict or relaxed

AMP-binding (539..929): Ile

nrpys: Ile

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LHLTFDASLQGRDCLVGGEFNVYGPTECCVDSTW
Nearest Stachelhaus code(s):: Ile DAQDLGVVDK (76% 8Å match); Gln DAQDLGVVDK (74% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2618..3022): X

nrpys: Orn, Lys, Arg

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Long positively charged side chain (Orn, Lys, Arg)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LLLGFDAFVGSAHCLVGGEHNVYGMIESGLAAAS
Nearest Stachelhaus code(s):: R-bmeTrp DAGALGVVLK (44% 8Å match); Hpg or Cl2-Hpg DAYHLGLLCK (41% 8Å match); Hpg DAFHLGLLCK (38% 8Å match)
Stachelhaus code match:: 70% (weak)

FEO89_RS15695: Ser - Val

Search NORINE for peptide: strict or relaxed

AMP-binding (1097..1503): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: RWATFDVSVWELHFLCSGEHNLYGPTEAAIDVTA
Nearest Stachelhaus code(s):: Ser DVWHLSLIDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2160..2557): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: LDPSFDSSVLEGFLMMGGDIHAYGPTENTVYTTC
Nearest Stachelhaus code(s):: Leu DALFMGAVAK (50% 8Å match); Gly DALFMGAVAK (47% 8Å match)
Stachelhaus code match:: 80% (moderate)

FEO89_RS15700: Ser - mal

Search NORINE for peptide: strict or relaxed

AMP-binding (541..942): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: RWMTFDVSVWEWHFFASGEHNLYGPTEAAIDVSY
Nearest Stachelhaus code(s):: Ser DVWHFSLIDK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

PKS_AT (1676..1971): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 83.3%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 179.4
inactive: 107.0
Methoxymalonyl-CoA: 70.8
Methylmalonyl-CoA: 57.6
Propionyl-CoA: 43.4
Isobutyryl-CoA: 38.5
Ethylmalonyl-CoA: 24.0
fatty_acid: 19.8
Acetyl-CoA: 19.2
2-Methylbutyryl-CoA: 16.7
CHC-CoA: 15.7
Benzoyl-CoA: 12.1
3-Methylbutyryl-CoA: 10.1
trans-1,2-CPDA: 0.0

FEO89_RS15705: mal

PKS_AT (1322..1615): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 173.1
inactive: 107.3
Methoxymalonyl-CoA: 68.8
Methylmalonyl-CoA: 61.1
Propionyl-CoA: 41.7
Isobutyryl-CoA: 31.1
Ethylmalonyl-CoA: 30.7
2-Methylbutyryl-CoA: 27.7
Benzoyl-CoA: 24.5
CHC-CoA: 19.5
trans-1,2-CPDA: 14.4
Acetyl-CoA: 10.5
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0

FEO89_RS15720: Thr

Search NORINE for peptide: strict or relaxed

AMP-binding (403..802): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: LATHFDFSVWEGNQIFGGEVNMFGITETTVHVTW
Nearest Stachelhaus code(s):: Thr DFWNIGMVHK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
RpoN	Regulator of nitrogen assimilation and virulence

NZ_CP040438.1 - Region 8 - arylpolyene

Download region GenBank file

Download region SVG

Location: 4,584,293 - 4,627,895 nt. (total: 43,603 nt) Show pHMM detection rules used

arylpolyene: (APE_KS1 or APE_KS2)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase reductase

FEO89_RS20815: alkyl hydroperoxide reductase subunit

smcogs: SMCOG1176: alkyl hydroperoxide reductase subunit

FEO89_RS20840: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

FEO89_RS20890: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: acyltransferase halogenase

FEO89_RS20910: conventional flavin-dependent halogenase

halogenases: conventional flavin-dependent halogenase
smcogs: SMCOG1119: halogenase

FEO89_RS20965: acyltransferase

smcogs: SMCOG1141: acyltransferase

Hydrolases: hydrolase

FEO89_RS20845: alpha/beta hydrolase fold protein

smcogs: SMCOG1036: alpha/beta hydrolase fold protein

Ligases: ligase synthase

FEO89_RS20885: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

FEO89_RS20900: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

FEO89_RS20940: polyprenol-monophosphomannose synthase ppm1

smcogs: SMCOG1123: polyprenol-monophosphomannose synthase ppm1

FEO89_RS20945: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002341.2	0.75	other (other)	3,5-dibromo-p-anisic acid	Planctomycetales bacterium 10988
BGC0002608.2	0.74	NRPS, PKS	ochratoxin A	Aspergillus steynii
BGC0002008.3	0.63	other (other)	aryl polyenes	Xenorhabdus doucetiae
BGC0000836.5	0.62	other (other)	APE Ec	Escherichia coli CFT073
BGC0002276.2	0.60	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001160.5	0.59	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.59	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001895.4	0.50	PKS	huanglongmycin A, huanglongmycin B, huanglongmycin C	Streptomyces sp. CB09001
BGC0002000.4	0.49	PKS	setomimycin	Streptomyces aurantiacus JA 4570
BGC0001723.5	0.49	PKS	oviedomycin	Streptomyces antibioticus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002341.2	0.75	other (other)	3,5-dibromo-p-anisic acid	Planctomycetales bacterium 10988
BGC0002608.2	0.74	NRPS, PKS	ochratoxin A	Aspergillus steynii
BGC0002008.3	0.63	other (other)	aryl polyenes	Xenorhabdus doucetiae
BGC0000836.5	0.62	other (other)	APE Ec	Escherichia coli CFT073
BGC0002276.2	0.60	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001160.5	0.59	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.59	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001895.4	0.50	PKS	huanglongmycin A, huanglongmycin B, huanglongmycin C	Streptomyces sp. CB09001
BGC0002000.4	0.49	PKS	setomimycin	Streptomyces aurantiacus JA 4570
BGC0001723.5	0.49	PKS	oviedomycin	Streptomyces antibioticus

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 23.25 out of 29.72

Confidence: medium

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.99 out of 20.47

Confidence: medium

Additional weak hits (7):

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 15.18 out of 26.06

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 17.30 out of 21.84

Confidence: weak

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.23 out of 27.55

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.06 out of 26.33

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 18.60 out of 29.25

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 20.50 out of 26.12

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 18.63 out of 33.14

Confidence: weak

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS substrates

TFBS Finder

NRPS/PKS substrate predictions

FEO89_RS20945: X

AMP-binding (51..300): X

nrpys: Gly, Ala, Val, Leu, Ile, Abu, Ival

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: EALH---LLFRWVAFSSGGTEVYGSSETGGIAWR
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
NtrC	Nitrogen regulatory protein C
VqsM	Regulator of quorum-sensing signalling systems