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Overview
1.1
1.2
1.3
1.4
1.5

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP045729.1 (Limosilactobacillus gastricus)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1.1 | furan | 588,507 | 609,178 |
Region 1.2 | T3PKS | 1,043,859 | 1,085,019 |
Region 1.3 | terpene-precursor | 1,128,879 | 1,149,748 |
Region 1.4 | lanthipeptide-class-ii,RiPP-like | 1,550,819 | 1,576,335 |
Region 1.5 | RiPP-like | 1,642,452 | 1,654,587 |

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1.1 | furan | 588,507 | 609,178 |
Region 1.2 | T3PKS | 1,043,859 | 1,085,019 |
Region 1.3 | terpene-precursor | 1,128,879 | 1,149,748 |
Region 1.4 | lanthipeptide-class-ii,RiPP-like | 1,550,819 | 1,576,335 |
Region 1.5 | RiPP-like | 1,642,452 | 1,654,587 |

No secondary metabolite regions were found in these records:
  NZ_CP045730.1 (Limosilactobacillus gastricus)
  NZ_CP045731.1 (Limosilactobacillus gastricus)

Compact view
NZ_CP045729.1 - Region 1 - furan
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 588,507 - 609,178 nt. (total: 20,672 nt) Show pHMM detection rules used
furan: (mmyO or AvrD)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | furan | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001639.3 |  | 0.40 | ribosomal | klebsidin | Klebsiella pneumoniae
BGC0000516.4 |  | 0.36 | ribosomal | geobacillin II | Geobacillus thermodenitrificans
BGC0000513.3 |  | 0.36 | ribosomal | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0000551.5 |  | 0.36 | ribosomal | SapB | Streptomyces coelicolor A3(2)
BGC0002442.3 |  | 0.35 | ribosomal | toyoncin | Bacillus toyonensis
BGC0000504.5 |  | 0.35 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000501.3 |  | 0.35 | ribosomal | catenulipeptin | Catenulispora acidiphila DSM 44928
BGC0001289.5 |  | 0.35 | ribosomal | penisin | Paenibacillus ehimensis
BGC0000500.5 |  | 0.34 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0002698.2 |  | 0.34 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001639.3 |  | 0.40 | ribosomal | klebsidin | Klebsiella pneumoniae
BGC0000516.4 |  | 0.36 | ribosomal | geobacillin II | Geobacillus thermodenitrificans
BGC0000513.3 |  | 0.36 | ribosomal | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0000551.5 |  | 0.36 | ribosomal | SapB | Streptomyces coelicolor A3(2)
BGC0002442.3 |  | 0.35 | ribosomal | toyoncin | Bacillus toyonensis
BGC0000504.5 |  | 0.35 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000501.3 |  | 0.35 | ribosomal | catenulipeptin | Catenulispora acidiphila DSM 44928
BGC0001289.5 |  | 0.35 | ribosomal | penisin | Paenibacillus ehimensis
BGC0000500.5 |  | 0.34 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0002698.2 |  | 0.34 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 20.12 out of 23.79
Confidence: medium
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 21.64 out of 26.33
Confidence: medium
Additional weak hits (1):
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 22.28 out of 29.65
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ANR | Anaerobic transcriptional regulator
IolR | Regulator of the inositol catabolism

NZ_CP045729.1 - Region 2 - T3PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,043,859 - 1,085,019 nt. (total: 41,161 nt) Show pHMM detection rules used
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxidoreductase
LG045_RS05180: 3-hydroxyisobutyrate dehydrogenase

smcogs
  SMCOG1100: 3-hydroxyisobutyrate dehydrogenase

LG045_RS05215: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

LG045_RS05230: dehydrogenase

smcogs
  SMCOG1072: dehydrogenase

LG045_RS05310: aldo/keto reductase family oxidoreductase

smcogs
  SMCOG1039: aldo/keto reductase family oxidoreductase

Transferases: acetyltransferase aminotransferase
LG045_RS05210: Chloramphenicol acetyltransferase

smcogs
  SMCOG1156: Chloramphenicol acetyltransferase

LG045_RS05260: aminotransferase

smcogs
  SMCOG1019: aminotransferase

Isomerases: mutase
LG045_RS05240: phosphoglycerate mutase

smcogs
  SMCOG1101: phosphoglycerate mutase

Ligases: synthase synthetase
LG045_RS05135: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

LG045_RS05245: hydroxymethylglutaryl-CoA synthase

smcogs
  SMCOG1043: hydroxymethylglutaryl-CoA synthase

LG045_RS05300: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs
  SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | T3PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001361.3 |  | 0.48 | terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0002283.2 |  | 0.48 | terpene | sodorifen | Serratia plymuthica
BGC0002115.3 |  | 0.44 | ribosomal | streptamidine | Streptomyces albidoflavus J1074
BGC0002306.2 |  | 0.43 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0001590.5 |  | 0.43 | PKS | formicamycin A, formicamycin B, formicamycin C, formicamycin D, formicamycin E, formicamycin F, formicamycin G, formicamycin H, formicamycin I, formicamycin J, formicamycin K, formicamycin L, formicamycin M, fasamycin C, fasamycin D, fasamycin E | Streptomyces sp. KY5
BGC0002561.3 |  | 0.43 | other (other) | phenazine SA, phenazine SB, phenazine SC | Streptomyces sp.
BGC0000889.5 |  | 0.43 | other (other) | bagremycin A, bagremycin B | Streptomyces sp. WK-5344
BGC0000558.5 |  | 0.43 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0001488.3 |  | 0.42 | other (other) | 4-formylaminooxyvinylglycine | Pseudomonas fluorescens WH6
BGC0001594.3 |  | 0.42 | other (other) | fischerindole L | Fischerella muscicola UTEX 1829

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001361.3 |  | 0.48 | terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0002283.2 |  | 0.48 | terpene | sodorifen | Serratia plymuthica
BGC0002115.3 |  | 0.44 | ribosomal | streptamidine | Streptomyces albidoflavus J1074
BGC0002306.2 |  | 0.43 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0001590.5 |  | 0.43 | PKS | formicamycin A, formicamycin B, formicamycin C, formicamycin D, formicamycin E, formicamycin F, formicamycin G, formicamycin H, formicamycin I, formicamycin J, formicamycin K, formicamycin L, formicamycin M, fasamycin C, fasamycin D, fasamycin E | Streptomyces sp. KY5
BGC0002561.3 |  | 0.43 | other (other) | phenazine SA, phenazine SB, phenazine SC | Streptomyces sp.
BGC0000889.5 |  | 0.43 | other (other) | bagremycin A, bagremycin B | Streptomyces sp. WK-5344
BGC0000558.5 |  | 0.43 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0001488.3 |  | 0.42 | other (other) | 4-formylaminooxyvinylglycine | Pseudomonas fluorescens WH6
BGC0001594.3 |  | 0.42 | other (other) | fischerindole L | Fischerella muscicola UTEX 1829

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.87 out of 20.97
Confidence: strong
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 24.74 out of 26.33
Confidence: strong
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 21.93 out of 26.33
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.38 out of 27.78
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.68 out of 27.78
Confidence: medium
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 26.57 out of 33.14
Confidence: medium
Additional weak hits (6):
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 23.28 out of 28.14
Confidence: weak
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.62 out of 21.55
Confidence: weak
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.17 out of 20.01
Confidence: weak
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.36 out of 26.85
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.19 out of 29.38
Confidence: weak
BldD
Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 18.70 out of 23.43
Confidence: weak
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ANR | Anaerobic transcriptional regulator
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
ZuR variant 2 | Zinc-responsive repressor

NZ_CP045729.1 - Region 3 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,128,879 - 1,149,748 nt. (total: 20,870 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: acetyltransferase formyltransferase
LG045_RS05570: methionyl-tRNA formyltransferase

smcogs
  SMCOG1228: methionyl-tRNA formyltransferase

LG045_RS10035: Chloramphenicol acetyltransferase

smcogs
  SMCOG1156: Chloramphenicol acetyltransferase

Hydrolases: peptidase
LG045_RS05645: methionine aminopeptidase

smcogs
  SMCOG1172: methionine aminopeptidase

Ligases: synthetase
LG045_RS05615: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0001605.3 |  | 0.40 | terpene | gibberellin | Sinorhizobium fredii NGR234
BGC0001618.3 |  | 0.39 | ribosomal | hyicin 3682 | Staphylococcus hyicus
BGC0002398.2 |  | 0.39 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0002218.2 |  | 0.38 | terpene | (-)-Cyatha-3,12-diene | Dentipellis sp. KUC8613
BGC0000678.5 |  | 0.38 | terpene | pentalenolactone | Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0000639.3 |  | 0.38 | terpene | carotenoid | Enterobacteriaceae bacterium DC260
BGC0000642.3 |  | 0.38 | terpene | carotenoid | Enterobacteriaceae bacterium DC413
BGC0000533.3 |  | 0.38 | ribosomal | mutacin III | Streptococcus mutans

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0001605.3 |  | 0.40 | terpene | gibberellin | Sinorhizobium fredii NGR234
BGC0001618.3 |  | 0.39 | ribosomal | hyicin 3682 | Staphylococcus hyicus
BGC0002398.2 |  | 0.39 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0002218.2 |  | 0.38 | terpene | (-)-Cyatha-3,12-diene | Dentipellis sp. KUC8613
BGC0000678.5 |  | 0.38 | terpene | pentalenolactone | Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0000639.3 |  | 0.38 | terpene | carotenoid | Enterobacteriaceae bacterium DC260
BGC0000642.3 |  | 0.38 | terpene | carotenoid | Enterobacteriaceae bacterium DC413
BGC0000533.3 |  | 0.38 | ribosomal | mutacin III | Streptococcus mutans

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP

Genes with terpene domains:
LG045_RS05615: PT_FPPS_like
Domain 1 (28 - 271): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:
  IPP, DMAPP → FPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 21.59 out of 24.78
Confidence: medium
Additional weak hits (2):
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 22.06 out of 28.14
Confidence: weak
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 19.95 out of 24.78
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
LexA variant 2 | Repressor of DNA damage response

NZ_CP045729.1 - Region 4 - RiPP-like,lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,550,819 - 1,576,335 nt. (total: 25,517 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Lyases: cyclase
LG045_RS07895: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0000617.5 |  |  | 0.32 | ribosomal | coagulin | Bacillus coagulans
BGC0002579.2 |  |  | 0.30 | ribosomal | carnobacteriocin XY | Carnobacterium maltaromaticum
BGC0000500.5 |  |  | 0.26 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0002577.2 |  |  | 0.26 | ribosomal | lactococcin G | Lactococcus lactis
BGC0000624.3 |  |  | 0.25 | ribosomal | salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide | Lactobacillus salivarius
BGC0001388.3 |  |  | 0.25 | ribosomal | gassericin E | Lactobacillus gasseri
BGC0000619.3 |  |  | 0.25 | ribosomal | gassericin T | Lactobacillus gasseri
BGC0001602.3 |  |  | 0.25 | ribosomal | gassericin-T | Lactobacillus gasseri
BGC0002698.2 |  |  | 0.23 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0001887.3 |  |  | 0.23 | ribosomal | huazacin | Bacillus thuringiensis serovar huazhongensis BGSC 4BD1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000617.5 |  | 0.49 | ribosomal | coagulin | Bacillus coagulans
BGC0002579.2 |  | 0.47 | ribosomal | carnobacteriocin XY | Carnobacterium maltaromaticum
BGC0000500.5 |  | 0.47 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0002577.2 |  | 0.44 | ribosomal | lactococcin G | Lactococcus lactis
BGC0000624.3 |  | 0.43 | ribosomal | salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide | Lactobacillus salivarius
BGC0002698.2 |  | 0.43 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0001388.3 |  | 0.43 | ribosomal | gassericin E | Lactobacillus gasseri
BGC0000619.3 |  | 0.43 | ribosomal | gassericin T | Lactobacillus gasseri
BGC0001602.3 |  | 0.43 | ribosomal | gassericin-T | Lactobacillus gasseri
BGC0000517.4 |  | 0.43 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for LG045_RS07895

LG045_RS07910
Leader:
MSKEELNSIVGRAFEEMDIQQMTSIQGS
Core:
G T E T A Q S T P A I S R V T L S I A R K S S A K C I S W I S F S A G G L N S Y K S K C
Core with dehydrations:
G Dhb E Dhb A Q Dha Dhb P A I Dha R V Dhb L Dha I A R K Dha Dha A K Cys I Dha W I Dha F Dha A G G L N Dha Y K Dha K Cys

#### antiSMASH-DB 4.0 matches for LG045_RS07910

100.0%
NZ_CP045729.1:
Lanthipeptides: LG045_RS07910_lanthipeptide
1
G T E T A Q S T P A I S R V T L S I A R K S S A K C I S W I S F S A G G L N S Y K S K C
44
G T E T A Q S T P A I S R V T L S I A R K S S A K C I S W I S F S A G G L N S Y K S K C
1
G T E T A Q S T P A I S R V T L S I A R K S S A K C I S W I S F S A G G L N S Y K S K C
44
40.9%
NZ_JACSPZ010000014.1:
Lanthipeptides: H9635_RS18390_lanthipeptide
1
G T E T A Q S T P A I S R V T L S I A R K S S A K C I S W I S F S A G G L N S Y K S K C
44
G +T P L S A K S S K C+ I S + G L S Y C
2
G V V E P H T T P-----I L S A A T K S S K K C L G A I S-A I S G L V S Y N K D C
39
35.6%
NZ_MRXY01000010.1:
Lanthipeptides: BTU63_RS06300_lanthipeptide
8
T P A I S R V T L S I A R K S S A K C I S W I S F S A G G L N S Y K S K C
44
T P I L A +S S C I S I G G+ S Y + C
11
T P T I----L K S A A R S S K V C I S A I I S G I G G I F S Y N N D C
43
with 13 more sequence matches
Only the first 10 are displayed here.
31.8%
NZ_KN125582.1:
Lanthipeptides: DJ91_RS27550_lanthipeptide
16
L S I A R K S S A K C I S W I S F S A G G L N S Y K S K C
44
+ ++R S S A K C S I S + G L S Y C
12
I V V S R I S S A K C A S T I S-A I S G L V S Y N K D C
39
29.5%
NZ_CP045729.1:
Lanthipeptides: allorf_1568662_1568871_lanthipeptide
1
G T E T A Q S T P A I S R V T L S I A R K S S A K C I S W I S F S A G
35
G E+A Q++P I I++ S S +C W+S +G
7
G A E S A Q T S P L I P-----I S K A S S V R C A K W V S A I S G
36
28.9%
NC_003028.3 and 39 others:
NC_003098.1 Lanthipeptides: SPR_RS08860_lanthipeptide NC_011900.1 Lanthipeptides: SPN23F_RS10045_lanthipeptide NC_012466.1 Lanthipeptides: SPJ_RS09630_lanthipeptide NZ_CFDV01000030.1 Lanthipeptides: AQB43_RS08315_lanthipeptide NZ_CFVJ01000005.1 Lanthipeptides: AP598_RS03270_lanthipeptide NZ_CGGJ01000006.1 Lanthipeptides: AP607_RS03210_lanthipeptide NZ_CHVQ01000007.1 Lanthipeptides: AQF85_RS04280_lanthipeptide NZ_CJZM01000008.1 Lanthipeptides: AEE29_RS04150_lanthipeptide NZ_CLHL01000007.1 Lanthipeptides: AE723_RS05755_lanthipeptide NZ_CMIW01000004.1 Lanthipeptides: AD046_RS04070_lanthipeptide NZ_CP035253.1 Lanthipeptides: EQH27_RS09735_lanthipeptide NZ_CP082820.1 Lanthipeptides: K8B76_RS08860_lanthipeptide NZ_CPRX01000013.1 Lanthipeptides: AEE77_RS05815_lanthipeptide NZ_CPTT01000011.1 Lanthipeptides: AEH42_RS06005_lanthipeptide NZ_CRAW01000006.1 Lanthipeptides: AK725_RS04390_lanthipeptide NZ_CRXO01000010.1 Lanthipeptides: AKU38_RS05255_lanthipeptide NZ_FCRW01000008.1 Lanthipeptides: A1N73_RS07430_lanthipeptide NZ_FDDE01000015.1 Lanthipeptides: A1A23_RS09710_lanthipeptide NZ_FDFR01000008.1 Lanthipeptides: A1O50_RS09315_lanthipeptide NZ_FDGF01000009.1 Lanthipeptides: A0899_RS06590_lanthipeptide NZ_FDQP01000009.1 Lanthipeptides: A1S42_RS08045_lanthipeptide NZ_FECM01000008.1 Lanthipeptides: A1930_RS06470_lanthipeptide NZ_FEEQ01000001.1 Lanthipeptides: A1T31_RS01150_lanthipeptide NZ_FEOS01000003.1 Lanthipeptides: A1178_RS03090_lanthipeptide NZ_FFTU01000009.1 Lanthipeptides: A1K37_RS06340_lanthipeptide NZ_FHRS02000028.1 Lanthipeptides: A1898_RS09825_lanthipeptide NZ_FIXQ01000010.1 Lanthipeptides: AZ721_RS04795_lanthipeptide NZ_FZDX01000018.1 Lanthipeptides: CFW91_RS09485_lanthipeptide NZ_FZEI01000008.1 Lanthipeptides: CFW58_RS06405_lanthipeptide NZ_JACVHZ010000010.1 Lanthipeptides: ICJ99_RS03885_lanthipeptide NZ_JAGFAE010000038.1 Lanthipeptides: J5E60_RS09010_lanthipeptide NZ_LR216014.1 Lanthipeptides: E0F05_RS09380_lanthipeptide NZ_LR216019.1 Lanthipeptides: E0E94_RS09630_lanthipeptide NZ_LR216027.1 Lanthipeptides: E0E81_RS09200_lanthipeptide NZ_LR216049.1 Lanthipeptides: E0E96_RS09535_lanthipeptide NZ_LR216064.1 Lanthipeptides: E0F31_RS09520_lanthipeptide NZ_LR536843.1 Lanthipeptides: E0F34_RS09595_lanthipeptide NZ_NANQ01000003.1 Lanthipeptides: B5K28_RS01930_lanthipeptide NZ_NAOJ01000022.1 Lanthipeptides: B5K31_RS08010_lanthipeptide
Lanthipeptides: SP_RS09790_lanthipeptide
14
V T L S I A R K S S A K C I S W I S F S A G G L N S Y K S K C
44
+ L A S S C I S G G L S Y + C
13
I I L K S A A A S S K V C I S A A V S G I G G L V S Y N N D C
43
28.9%
NZ_CP035244.1 and 3 others:
NZ_CPPE01000023.1 Lanthipeptides: AD654_RS06870_lanthipeptide NZ_FHJP02000011.1 Lanthipeptides: A1O79_RS07380_lanthipeptide NZ_LR216016.1 Lanthipeptides: E0F10_RS10155_lanthipeptide
Lanthipeptides: EQH36_RS09100_lanthipeptide
14
V T L S I A R K S S A K C I S W I S F S A G G L N S Y K S K C
44
+ L A S S C I S G G L S Y + C
13
I I L K S A A A S S K I C I S A A V S G I G G L V S Y N N D C
43
28.9%
NZ_JALDUX010000010.1:
Lanthipeptides: M1F92_RS09530_lanthipeptide
14
V T L S I A R K S S A K C I S W I S F S A G G L N S Y K S K C
44
+ L A S S C I S + G G L S Y + C
13
L I L K S A A A S S K V C I S A L V S G I G G L V S Y N N D C
43
27.3%
NZ_FOXX01000007.1 and 6 others:
NZ_LVYL01000023.1 Lanthipeptides: allorf_421773_421910_lanthipeptide NZ_LVYL01000023.1 Lanthipeptides: allorf_421773_421910_lanthipeptide NZ_LWAG01000015.1 Lanthipeptides: allorf_021388_021525_lanthipeptide NZ_LWAG01000015.1 Lanthipeptides: allorf_021388_021525_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: allorf_188984_189121_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: allorf_188984_189121_lanthipeptide
Lanthipeptides: allorf_282390_282527_lanthipeptide
13
R V T L S I A R K S S A K C----I S W I S F S A G G L N S Y
40
R T L+I ++ S C +S F G L S Y
5
R S T L T I F K R Y S V L C S Y P F T K L L S F K N G H L R S Y
36
26.7%
NZ_JAMYJM010000002.1:
Lanthipeptides: NKE69_RS04880_lanthipeptide
16
L S I A R K S S A K C I S W I S F S A G G L N S Y K S K C
44
L A S S C I S + G G+ S Y + C
15
L K S A T A S S K V C I S A V V S G I G G I V S Y N N D C
43
26.1%
NZ_CP041405.1:
Lanthipeptides: FLT43_RS14400_lanthipeptide
6
Q S T P A I S R V T L S I A R K S S A K C I S W I S F S A G G L N S Y K S K C
44
++T P I + R S S C+S ++ + G G+ S+ + C
6
R A T P T I V P A I S A A V R T S S K V C L S L V A S A I G G I A S H N N D C
44
20.5%
NZ_AP026721.1 and 35 others:
NZ_CP015883.1 Lanthipeptides: A6B47_RS00875_lanthipeptide NZ_CP028286.1 Lanthipeptides: CEQ02_RS16115_lanthipeptide NZ_CP028721.1 Lanthipeptides: C7I32_RS15475_lanthipeptide NZ_CP028835.1 Lanthipeptides: C9432_RS02740_lanthipeptide NZ_CP028837.1 Lanthipeptides: C9432_RS15935_lanthipeptide NZ_CP033787.1 Lanthipeptides: EGX75_RS02740_lanthipeptide NZ_CP039296.1 Lanthipeptides: E7T02_RS02755_lanthipeptide NZ_CP045045.1 Lanthipeptides: F9293_RS12755_lanthipeptide NZ_CP075604.2 Lanthipeptides: KKP64_RS02155_lanthipeptide NZ_CP085289.1 Lanthipeptides: LIT95_RS07630_lanthipeptide NZ_CP085291.1 Lanthipeptides: LIT96_RS04335_lanthipeptide NZ_CP085297.1 Lanthipeptides: LIT97_RS14520_lanthipeptide NZ_CP086726.1 Lanthipeptides: LM507_RS03415_lanthipeptide NZ_CP091901.1 Lanthipeptides: L5I17_RS09010_lanthipeptide NZ_CP091905.1 Lanthipeptides: L5I20_RS14940_lanthipeptide NZ_CP091907.1 Lanthipeptides: L5I26_RS13265_lanthipeptide NZ_CP093957.1 Lanthipeptides: MPM64_RS01385_lanthipeptide NZ_CP116962.1 Lanthipeptides: PO880_RS13030_lanthipeptide NZ_JAASJP010000011.1 Lanthipeptides: HCH27_RS13275_lanthipeptide NZ_JAHZNN010000041.1 Lanthipeptides: K0X81_RS16410_lanthipeptide NZ_JAKTAU010000028.1 Lanthipeptides: MKK46_RS14535_lanthipeptide NZ_JALSCL010000035.1 Lanthipeptides: NEI30_RS13375_lanthipeptide NZ_JAQDOF010000024.1 Lanthipeptides: PGP79_RS14595_lanthipeptide NZ_JAQKZU010000014.1 Lanthipeptides: PMV60_RS12615_lanthipeptide NZ_KB932317.1 Lanthipeptides: Q95_RS09840_lanthipeptide NZ_KB932336.1 Lanthipeptides: Q9C_RS13350_lanthipeptide NZ_KB944697.1 Lanthipeptides: WO3_RS18030_lanthipeptide NZ_KB944708.1 Lanthipeptides: WO5_RS05650_lanthipeptide NZ_KB944753.1 Lanthipeptides: WO9_RS06460_lanthipeptide NZ_KB944762.1 Lanthipeptides: WOA_RS17470_lanthipeptide NZ_KB944819.1 Lanthipeptides: WOK_RS14355_lanthipeptide NZ_KB946767.1 Lanthipeptides: UK1_RS12990_lanthipeptide NZ_KB947483.1 Lanthipeptides: WUI_RS10440_lanthipeptide NZ_KZ845881.1 Lanthipeptides: EB41_RS04380_lanthipeptide NZ_NGMY01000001.1 Lanthipeptides: A5862_RS02370_lanthipeptide
Lanthipeptides: PO855_RS02215_lanthipeptide
1
G T E T A Q S T P A I S R V T L S I A R K S S A K
25
G A++T P A + L + S A K
1
G D V Q A E T T P A C F T I G L G V G A L F S A K
25
18.2%
NZ_JAENHN010000066.1 and 1 other:
NZ_JAENHN010000066.1 Lanthipeptides: JHL18_RS24425_lanthipeptide
Lanthipeptides: JHL18_RS24425_lanthipeptide
17
S I A R K S S A K C I S W I S F S A G G L
37
S+ R+ C +W I S+ +G G+
14
S L T R E C Q R L C-N W I S Y G S G G V
33
allorf_1568662_1568871
Leader:
MVNMLDSELKKIVGDSFEDMSVQQM
Core:
T S I Q G N G A E S A Q T S P L I P I S K A S S V R C A K W V S A I S G L S W A K H H K
Core with dehydrations:
Dhb Dha I Q G N G A E Dha A Q Dhb Dha P L I P I Dha K A Dha Dha V R Cys A K W V Dha A I Dha G L Dha W A K H H K

#### antiSMASH-DB 4.0 matches for allorf_1568662_1568871

100.0%
NZ_CP045729.1:
Lanthipeptides: allorf_1568662_1568871_lanthipeptide
1
T S I Q G N G A E S A Q T S P L I P I S K A S S V R C A K W V S A I S G L S W A K H H K
44
T S I Q G N G A E S A Q T S P L I P I S K A S S V R C A K W V S A I S G L S W A K H H K
1
T S I Q G N G A E S A Q T S P L I P I S K A S S V R C A K W V S A I S G L S W A K H H K
44
31.8%
NZ_KB976303.1 and 1 other:
NZ_KB976303.1 Lanthipeptides: IGY_RS26035_lanthipeptide
Lanthipeptides: IGY_RS26045_lanthipeptide
7
G A E S A Q T S P L I P I S K A S S V R C A K W V S A I S G L
37
G ++ +I +S+A S S C V S A I S G L
2
G V D T R T H P T V I V V S R A S S K A C M S G V S A I S G L
32
30.0%
NZ_JAFHCX010000012.1 and 1 other:
NZ_LR738722.1 Lanthipeptides: STREPSUIS_RS04080_lanthipeptide
Lanthipeptides: JXW96_RS06960_lanthipeptide
7
G A E S A Q T S P L I P--------I S K A S S V R C A K W V S A I S G
36
G S A+ +P P +K A S S C A +A I S G
1
G D M S A E L T P T T P A C Y A S I I Y T A K A S S P N C A Y A A T A I S G
38
with 11 more sequence matches
Only the first 10 are displayed here.
29.5%
NZ_CP045729.1:
Lanthipeptides: LG045_RS07910_lanthipeptide
7
G A E S A Q T S P L I P-----I S K A S S V R C A K W V S A I S G
36
G E+A Q++P I I++ S S +C W+S +G
1
G T E T A Q S T P A I S R V T L S I A R K S S A K C I S W I S F S A G
35
29.5%
NZ_KN125582.1:
Lanthipeptides: DJ91_RS27550_lanthipeptide
6
N G A E S A Q T S P L I P I S K A S S V R C A K W V S A I S G L
37
+G ++ +I +S+ S S +C A +S A I S G L
1
S G V D T R T H P T V I V V S R I S S A K C A S T I S A I S G L
32
27.3%
NZ_JACSPZ010000014.1:
Lanthipeptides: H9635_RS18390_lanthipeptide
6
N G A E S A Q T S P L I P I S K A S S V R C A K W V S A I S G L
37
+G T+P++ + S S +C +S A I S G L
1
S G V V E P H T T P I L S A A T K S S K K C L G A I S A I S G L
32
25.0%
NZ_JAQDYA010000001.1:
Lanthipeptides: PGT72_RS00025_lanthipeptide
12
Q T S P L I P I S K A S S V R C A K W V S A I S G L
37
+T+P+ + A S S C A S A+S G+
6
E T T P V C A A T V A S S A Y C A G A A S A V S G I
31
22.9%
NZ_FPCC01000026.1:
Lanthipeptides: BM377_RS12905_lanthipeptide
4
Q G N G A E S A Q T S P L I-P I S K A S S V
25
Q G G A+T+P+I P I S+V
14
Q G A G D V D A E T T P V I M P I C S P S A V
36
21.6%
NZ_CP040414.1:
Lanthipeptides: FE331_RS05905_lanthipeptide
6
N G A E S-A Q T S P L I P I S K A S S V R C A K W V S A I S
35
N G A++ Q + P+ A S C A +S A++
3
N G A D N F G Q D R A V T P V V S A S L K F C A P A I S A V T
33
20.5%
NZ_CP083636.1:
Lanthipeptides: LA320_RS07060_lanthipeptide
11
A Q T S P L I P I S K A S S V R C A K W V S
32
A+T+P+ + A S S+ C A V+
5
A E T T P V C A F T A A S S I V C A D V V T
26
20.5%
NZ_JAHTIK010000001.1:
Lanthipeptides: allorf_2155695_2155844_lanthipeptide
11
A Q T S P L I P I S K A S S V R C A K
29
A T P L P S S R C++
11
A A T R P L T P P H P G S S P R C S R
29
19.6%
NZ_CP076103.1:
Lanthipeptides: allorf_5471922_5472122_lanthipeptide
7
G A E S A Q T S P L I P I S K A S S V R C A K W V S A I S G
36
G A+S+Q P I++A+ + C A+ +G
22
G A D S S Q E----P I A Q A T W I T C A E V C D R F A G
47
18.2%
NZ_PNGT01000002.1:
Lanthipeptides: CJ218_RS03225_lanthipeptide
11
A Q T S P L I P I S K A S S V R C A K W V S
32
A+T+P+ + A S S+ C A ++
5
A E T T P V C A F T A A S S I A C A D V I T
26

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 15.60 out of 18.16
Confidence: strong
Additional weak hits (3):
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 22.75 out of 28.14
Confidence: weak
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 24.41 out of 30.97
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.62 out of 29.25
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

LG045_RS07910 - Class II
  Cleavage pHMM score: -3.70
  RODEO score: 0
  Monoisotopic mass: 4339.4 Da
  Molecular weight: 4341.9 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4359.9 Da N = 1
    4377.9 Da N = 2
    4396.0 Da N = 3
    4414.0 Da N = 4
    4432.0 Da N = 5
    4450.0 Da N = 6
    4468.0 Da N = 7
    4486.1 Da N = 8
    4504.1 Da N = 9
    4522.1 Da N = 10
    4540.1 Da N = 11
    4558.1 Da N = 12
allorf_1568662_1568871 - Class II
  Cleavage pHMM score: -4.40
  RODEO score: 0
  Monoisotopic mass: 4390.4 Da
  Molecular weight: 4392.9 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4411.0 Da N = 1
    4429.0 Da N = 2
    4447.0 Da N = 3
    4465.0 Da N = 4
    4483.0 Da N = 5
    4501.1 Da N = 6
    4519.1 Da N = 7
    4537.1 Da N = 8
    4555.1 Da N = 9
    4573.1 Da N = 10

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator

NZ_CP045729.1 - Region 5 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,642,452 - 1,654,587 nt. (total: 12,136 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
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Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: amidase hydrolase
LG045_RS08340: hydrolase

smcogs
  SMCOG1179: hydrolase

LG045_RS08355: amidase

smcogs
  SMCOG1105: amidase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000558.5 |  | 0.48 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0002579.2 |  | 0.48 | ribosomal | carnobacteriocin XY | Carnobacterium maltaromaticum
BGC0001555.4 |  | 0.47 | ribosomal | colicin V | Escherichia coli chi7122
BGC0001862.4 |  | 0.44 | ribosomal | pallidocin | Aeribacillus pallidus
BGC0000554.4 |  | 0.44 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000588.5 |  | 0.44 | ribosomal | microcin L | Escherichia coli
BGC0000617.5 |  | 0.44 | ribosomal | coagulin | Bacillus coagulans
BGC0000504.5 |  | 0.43 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0001388.3 |  | 0.42 | ribosomal | gassericin E | Lactobacillus gasseri
BGC0000619.3 |  | 0.42 | ribosomal | gassericin T | Lactobacillus gasseri

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000558.5 |  | 0.48 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0002579.2 |  | 0.48 | ribosomal | carnobacteriocin XY | Carnobacterium maltaromaticum
BGC0001555.4 |  | 0.47 | ribosomal | colicin V | Escherichia coli chi7122
BGC0001862.4 |  | 0.44 | ribosomal | pallidocin | Aeribacillus pallidus
BGC0000554.4 |  | 0.44 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000588.5 |  | 0.44 | ribosomal | microcin L | Escherichia coli
BGC0000617.5 |  | 0.44 | ribosomal | coagulin | Bacillus coagulans
BGC0000504.5 |  | 0.43 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0001388.3 |  | 0.42 | ribosomal | gassericin E | Lactobacillus gasseri
BGC0000619.3 |  | 0.42 | ribosomal | gassericin T | Lactobacillus gasseri

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 21.59 out of 24.78
Confidence: medium
Additional weak hits (2):
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.73 out of 39.62
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 23.81 out of 29.65
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
LexA variant 2 | Repressor of DNA damage response
ToxT | Regulator of MSHA biosynthesis