LOCUS       NZ_CP045572            25662 bp    DNA     circular CON 07-NOV-2024
DEFINITION  Nonomuraea phyllanthi strain WYY166 chromosome, complete genome.
ACCESSION   NZ_CP045572
VERSION     NZ_CP045572.1
KEYWORDS    RefSeq.
SOURCE      Nonomuraea phyllanthi
  ORGANISM  Nonomuraea phyllanthi
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Streptosporangiales; Streptosporangiaceae; Nonomuraea.
REFERENCE   1  (bases 1 to 11273186)
  AUTHORS   Ou,Y. and Wu,Y.
  TITLE     Nonomuraea nitratireducens sp. nov., a new actinobacterium isolated
            from Suaeda australis Moq. rhizosphere
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 11273186)
  AUTHORS   Ou,Y. and Wu,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (15-OCT-2019) School of Life Sciences and Biotechnology,
            Shanghai Jiao Tong University, Dongchuan, Shanghai 200240, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. Aug-2018
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 160.0x
            Sequencing Technology             :: PacBio RSII; Illumina NextSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_009497075.1-RS_2024_11_06
            Annotation Date                   :: 11/06/2024 06:36:57
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 10,403
            CDSs (total)                      :: 10,325
            Genes (coding)                    :: 10,209
            CDSs (with protein)               :: 10,209
            Genes (RNA)                       :: 78
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 60
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 116
            CDSs (without protein)            :: 116
            Pseudo Genes (ambiguous residues) :: 0 of 116
            Pseudo Genes (frameshifted)       :: 22 of 116
            Pseudo Genes (incomplete)         :: 104 of 116
            Pseudo Genes (internal stop)      :: 8 of 116
            Pseudo Genes (multiple problems)  :: 13 of 116
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 17:05:15
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 10900320
            Orig. end                         :: 10925982
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP045572.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..25662
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="30"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..25662
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25662
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:15662](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..15662
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    352..363
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.76"
                     /tool="antismash"
     misc_feature    1292..1310
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 20.84"
                     /tool="antismash"
     misc_feature    2552..2565
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.84"
                     /tool="antismash"
     misc_feature    complement(2960..2974)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: strong, score: 28.65"
                     /tool="antismash"
     misc_feature    2961..2975
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: strong, score: 28.15"
                     /tool="antismash"
     misc_feature    complement(3163..3177)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: strong, score: 30.11"
                     /tool="antismash"
     misc_feature    3164..3178
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: strong, score: 29.02"
                     /tool="antismash"
     gene            3238..5559
                     /locus_tag="GBF35_RS54125"
                     /old_locus_tag="GBF35_49855"
     CDS             3238..5559
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0030245 - cellulose catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012893324.1"
                     /locus_tag="GBF35_RS54125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBF35_49855"
                     /product="glycoside hydrolase family 6 protein"
                     /protein_id="WP_317619811.1"
                     /transl_table=11
                     /translation="MTVTAASVAALGLVVGQSTAANAAAGCDVTYSANSWTSSPGQGGF
                     TANITLKNTGDPISSWTLAFDYPTSGQKYTPSGWGANWSQSGTRVTGTSMPWNGSLSTG
                     ASVSVGFNGTWSGTNPNPTSFSVNGNTCGGVNPTTPSVVTSPSSVAVNEGGTATFTAKL
                     SSAPSSNVTVTTTRTSGDTDLSVSAGGSLTFTPSNWNTAQTVTLAAAQDSDTTAGTASF
                     TVGGTGVTAATLSATEVDDDAVVEQSIIVTPTSVTVPEGSTATYSVRLATQPSSNVTVT
                     STAGSGDANITVSSGASLTFTSSNWNTAQTVTLAAAQDSDTANGSRTITVASSGLTSRT
                     VTATEADDDDTGTPGGHVENPYSGATGYVNPDWKAKAQAEPGGSAVANTSTAVWLDRIA
                     AIEGANGAMGLREHLDEAVRQDAANGSTPLTVQFVIYDLPNRDCSALASNGELRISENG
                     FNRYKTEYIDPIASIMSDSAYSNLRIVTIIEPDSLPNLITNINKFADCQEANGPGGYVD
                     GVRYALNKLHAMSNVYTYIDAAHHAWLGWDSNFGPSVDLFYNTVSGTTAGVDSVDGFIV
                     NTANYSATTEPYFTINSTVNGQSVRQSKWVDWNYYVDEKTFATALRSALIGKGFRQGLG
                     MLIDTSRNGWGGSARPSGPSTSTNVDEFVNDSRVDRRIHAGNWCNQSGAGMGERPTASP
                     AAGFDAYVWIKPPGESDGSSEEIDNDEGKRLDRMCDPTYHGNELNGNNLTGALPDAPLS
                     GRWFSAQFRELLANAYPPIN"
     gene            complement(5712..6113)
                     /locus_tag="GBF35_RS49885"
                     /old_locus_tag="GBF35_49860"
     CDS             complement(5712..6113)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020540764.1"
                     /locus_tag="GBF35_RS49885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBF35_49860"
                     /product="DUF1992 domain-containing protein"
                     /protein_id="WP_153265454.1"
                     /transl_table=11
                     /translation="MTERKPLGMPFESWVDRQIREAEERGAFDDLPCAGKPIPGLDRPH
                     DDMWWIKQKVESEGLSMPLPPTLALRKEAEEALAQARGARSETEARRIVEEINQKIREA
                     IRTGLSGPPLNLMPFDADEIVSEWRQARK"
     gene            complement(6123..7022)
                     /gene="folP"
                     /locus_tag="GBF35_RS49890"
                     /old_locus_tag="GBF35_49865"
     CDS             complement(6123..7022)
                     /EC_number="2.5.1.15"
                     /GO_function="GO:0004156 - dihydropteroate synthase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009396 - folic acid-containing compound
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="folP"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020540765.1"
                     /locus_tag="GBF35_RS49890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBF35_49865"
                     /product="dihydropteroate synthase"
                     /protein_id="WP_153265455.1"
                     /transl_table=11
                     /translation="MSGETLPPEIISPVRRIGRREFDFARQVAIMAIVNRTPNSFHDQG
                     RTFELDSAVTAARRAVDDGADWVDIGGFAFSAAQAGIGADEEIDRVAPVIAEVREVTDA
                     VISVDTHRPEVARAAVEAGADVINDTNGLREPGMAEFAAESGASVIVTHSLGGPGRRVF
                     RPSYADVVSEVTDYLRERVAYALKCGIAEDKIIIDPGHDLNKNTFHSLEITRRLEEVTA
                     IGHPTLVALSNKDFIGETLDRPQGERKEGTIAANVFCIVKGARILRVHDVAATVASVRM
                     TEAMLGWRGPLTPSHNLA"
     gene            complement(7019..7453)
                     /locus_tag="GBF35_RS49895"
                     /old_locus_tag="GBF35_49870"
     CDS             complement(7019..7453)
                     /EC_number="2.7.13.3"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024970.5"
                     /locus_tag="GBF35_RS49895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBF35_49870"
                     /product="ATP-binding protein"
                     /protein_id="WP_193318295.1"
                     /transl_table=11
                     /translation="MRTLMAQPFTLEDVTRLRRAVADLAGGRGLVGPRLDDFVLAVHES
                     VVNVVEHAGGYGYFRLWTADGVIGSETSDRGTGIPDGYMAADREPPGLAQRGRGIYLMR
                     RLCDTADFDTGPDGTTVRLAMRLPRGRDDGPGQVAGRLTM"
     gene            complement(7513..8562)
                     /locus_tag="GBF35_RS49900"
                     /old_locus_tag="GBF35_49875"
     CDS             complement(7513..8562)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: NAD_binding_4 (50-217). E-value:
                     9.2e-11. Score: 33.2. Matches aSDomain:
                     nrpspksdomains_GBF35_RS49900_NAD_binding_4.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012891984.1"
                     /locus_tag="GBF35_RS49900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBF35_49875"
                     /product="NAD-dependent epimerase/dehydratase family
                     protein"
                     /protein_id="WP_139629718.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 9.7e-06, bitscore:
                     24.1, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVVVVGATGNVGTSVVRALATDGGVTSIVGVARRLPRWRIDRTD
                     WRQADVATADLTRIFDGADAVVHLAWLFQPTRHPATTWRANVLGSMRVFRAVAEAGVPA
                     LVHASSVGAYSPGPKDRPVDESWPTHGWPGTAYAREKAYVERVLDVFENDHPGIRVVRM
                     RPGFIFQRAASTEQRRLFGGPFVPRRLIRAGRVPFVPEIPGLRLQVLHAEDAAEAYRLA
                     VTKDVRGPFNIAAEPVLDPPDLAKLLGARTVRVPAGLARAVMSAGWHLRLIPAAPSMLD
                     LVLQIPYMNTERAREVLGWTPRHSSWEAMQELFQGLHDGAGMDTAPLAPDGGPVQRAKE
                     LAGGVGARP"
     aSDomain        complement(7912..8412)
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_GBF35_RS49900_NAD_binding_4.1"
                     /evalue="9.20E-11"
                     /label="GBF35_RS49900_NAD_binding_4.1"
                     /locus_tag="GBF35_RS49900"
                     /protein_end="217"
                     /protein_start="50"
                     /score="33.2"
                     /tool="antismash"
                     /translation="VATADLTRIFDGADAVVHLAWLFQPTRHPATTWRANVLGSMRVFR
                     AVAEAGVPALVHASSVGAYSPGPKDRPVDESWPTHGWPGTAYAREKAYVERVLDVFEND
                     HPGIRVVRMRPGFIFQRAASTEQRRLFGGPFVPRRLIRAGRVPFVPEIPGLRLQVLHAE
                     DAAE"
     CDS_motif       complement(8491..8553)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_GBF35_RS49900_0001"
                     /evalue="1.60E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="GBF35_RS49900"
                     /protein_end="24"
                     /protein_start="3"
                     /score="11.1"
                     /tool="antismash"
                     /translation="VVVGATGNVGTSVVRALATDG"
     gene            complement(8615..9796)
                     /locus_tag="GBF35_RS49905"
                     /old_locus_tag="GBF35_49880"
     CDS             complement(8615..9796)
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0004022 - alcohol dehydrogenase (NAD+)
                     activity [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_function="GO:0030554 - adenyl nucleotide binding
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_ER (23-257). E-value: 7.9e-09.
                     Score: 27.0. Matches aSDomain:
                     nrpspksdomains_GBF35_RS49905_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1040: alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016188395.1"
                     /locus_tag="GBF35_RS49905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBF35_49880"
                     /product="zinc-dependent alcohol dehydrogenase"
                     /protein_id="WP_139629717.1"
                     /sec_met_domain="ADH_N (E-value: 1.9e-28, bitscore: 97.7,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 5.1e-13, bitscore:
                     48.4, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKAVTWHGKRDVRVEDVPDPAVKEPNDAVIRVTSTGICGSDLHLY
                     EVLGPFMAEGDIIGHEAMGVVEEVGPAVDTIKPGDRVVIPFNISCGHCHMCSMELYAQC
                     ETTQVREQGTGAALYGYTKLYGQVPGGQAEYLRVPEAQFGPIKVPEGGPDERFLFLSDV
                     LPTAWQAVAYADIPEGGSVTVYGLGPIGQMCARIAAHLGHRVIGVDGVTKRLEMARRHG
                     IDVVDASEVTDVPEEIRQRTSGRGTDSVIDAVGMEAHGSLGAKLAQTLTGMLPGAVAAP
                     LMTHTGVDRMAALNQSIDSVRRGGVISIIGVYGGMTDPMPMLRMFDKGITLRMGQAHVR
                     KWTSALMPLVTDESDPLGVMDLTTHRMPLERAPEAYEMFQRKKDGAIKIVLQP"
     aSDomain        complement(9026..9727)
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_GBF35_RS49905_PKS_ER.1"
                     /evalue="7.90E-09"
                     /label="GBF35_RS49905_PKS_ER.1"
                     /locus_tag="GBF35_RS49905"
                     /protein_end="257"
                     /protein_start="23"
                     /score="27.0"
                     /tool="antismash"
                     /translation="EPNDAVIRVTSTGICGSDLHLYEVLGPFMAEGDIIGHEAMGVVEE
                     VGPAVDTIKPGDRVVIPFNISCGHCHMCSMELYAQCETTQVREQGTGAALYGYTKLYGQ
                     VPGGQAEYLRVPEAQFGPIKVPEGGPDERFLFLSDVLPTAWQAVAYADIPEGGSVTVYG
                     LGPIGQMCARIAAHLGHRVIGVDGVTKRLEMARRHGIDVVDASEVTDVPEEIRQRTSGR
                     GTDSVIDAVGME"
     gene            10001..11044
                     /locus_tag="GBF35_RS49910"
                     /old_locus_tag="GBF35_49885"
     CDS             10001..11044
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012568.5"
                     /locus_tag="GBF35_RS49910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBF35_49885"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_226899131.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 3.6e-51, bitscore:
                     173.2, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSFTQHDVGSRVDRRLAGFLETWRAPVDDPDVEAAYRLLTDFILR
                     GGKRVRPRLCYWGWRGAGGDDSEEIITAAAALELCHAGLLIHDDIMDGSELRRGRVTVH
                     RSLAGLHHGPGAEMFGQAGGILLGTLSLAWSDTMLSSCGVEPHRLRAAHHVFDAMRTEV
                     ISGQYLDVLAQLRAGASVAEALTVIRFKTAKYTVERPLQIGGALAGASMELLESYSRFG
                     LPLGEAFQLRDDVLGTFGSESETGKSALDDLREGKHTVLFAHAVRKASPAQLRHLRRWH
                     GNPELTEERAEEVREILRDTGALAEVEQMIEERVHEAVTALSAARMEPEAAKALTLMAD
                     RLAHRTK"
     gene            11057..11992
                     /locus_tag="GBF35_RS49915"
                     /old_locus_tag="GBF35_49890"
     CDS             11057..11992
                     /EC_number="1.17.7.4"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0051745 - 4-hydroxy-3-methylbut-2-enyl
                     diphosphate reductase activity [Evidence IEA]"
                     /GO_process="GO:0019288 - isopentenyl diphosphate
                     biosynthetic process, methylerythritol 4-phosphate pathway
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020540770.1"
                     /locus_tag="GBF35_RS49915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBF35_49890"
                     /product="4-hydroxy-3-methylbut-2-enyl diphosphate
                     reductase"
                     /protein_id="WP_139629715.1"
                     /transl_table=11
                     /translation="MARVLLAAPRGFCAGVERAIATVEQALSRFGPPVYVRKQIVHNTY
                     VVGDLSRLGAIFVEELDEVPDGSLVVFSAHGVSPAVKEEAERRGLRTIDATCPLVTKVH
                     KEAVRMAEEGYEIVLIGHADHEEVEGTYGEAPGHIHVVDPARPGEVTAKGRVSWLSQTT
                     LSVDETMRAVAELRERFPDMADPPSDDICYASQNRQEAVAAIAPRCELVIVVGSANSSN
                     SRRLVEVALGAGADAAHLVDRADDADERWLAGVQTVGVTSGASVPDRLVGELLDWLAAR
                     GFTDVEPVTLTEETLTFSLPPEIRSTRKYG"
     misc_feature    11876..11878
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            12023..13438
                     /locus_tag="GBF35_RS49920"
                     /old_locus_tag="GBF35_49895"
     CDS             12023..13438
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1133:
                     Transcription regulator, crp"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017619264.1"
                     /locus_tag="GBF35_RS49920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBF35_49895"
                     /product="family 2B encapsulin nanocompartment shell
                     protein"
                     /protein_id="WP_139629714.1"
                     /transl_table=11
                     /translation="MTETTNSPAPETVNGNGQLSLSTEAARQLSTTTKTPPQMQEITSR
                     WLLRLLPWVQCSGGVFRVNRRLTYELGDGRITFSNTGSNVRVIPAELTEIPMLRGFDDA
                     EVLQALANGFAQREIEAGEEIVSEGRPVDRLVLIAHGRVAKVSRGAYGDEQNLGVLADG
                     DYLGEETLTQGGRYAFTARAKTATTVLTLSRQDFEQLADQSPGLREHLDRWLASGDHAQ
                     NDYGEAAIDVSSGHTGEPVLPGTFVDYELSPREYELSVAQTVLRVHSRVSDLYNQPMSQ
                     LDQQLRLTIEALRERQEHELINNKEFGLLHNSALSQRIRTRAGRPTPDDLDDLLATVWK
                     DPAFFLAHPQAIAAFGRECSKRGVYPQTSEVNGHRVPTWRGVPIFPCNKIPISGTYTTS
                     FLLMRTGQENQGVVGLHQTGIPDEYQPSLSVRFMNINEKAVISYLVSAYYSAAVLVPDA
                     LGVLEDVEVGRNG"
     gene            13503..15662
                     /locus_tag="GBF35_RS49925"
                     /old_locus_tag="GBF35_49900"
     CDS             13503..15662
                     /EC_number="4.2.3.-"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012886878.1"
                     /locus_tag="GBF35_RS49925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBF35_49900"
                     /product="terpene synthase family protein"
                     /protein_id="WP_153265456.1"
                     /sec_met_domain="T1TS (E-value: 2.1e-80, bitscore: 270.4,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSQPFELPDFYMPYPARLNPHLEAARAHSRQWARDMGMLDDPGVW
                     EEADLDSHDYPLMCAYTHPDCDAAELCLITDWYVWVFFFDDHFLEAFKRSGDLAGGKAH
                     LDRLPAFMPMGGDLSMPEPANPVEAGLADLWVRTVPSRSGDWRARFAESTRNLLNESLW
                     ELRNINTGRVSNPVEYIEMRRKVGGAPWSAGLVEHAVGAEVPARIAGSRPMRVLKDSFS
                     DAVHLRNDLFSYEREVGDEGELSNGVLVLETFLGCGTQEAANAVNDLLTSRMQQFEHTA
                     LTELGPLFVEHGVDPISAAGVLAYVKGLQDWQSGGHEWHLRSSRYMNKRATASRPLGMS
                     SVTDLLGAKRLRAFTHVPHQRVGPSRIPDLYVPFQLRLSPHLDAARRDTVAWCRAMGLL
                     DTGVWDERQLVDIDLPLCAAGLHPDAGPKELALASHWLAWGTYGDDYFPVVFGRSRNLA
                     AARIAVERFSGCMPLDGSPAPPPANAMERALADVWARTAGPMPPEHRRELRSAVESMCE
                     SWLWELANEIAHRIPDPVDYVEMRRSTFGSDLTMSLARLRHGRRIPREVHDSGPMRALV
                     SAITDCGTLINDIFSYQKEIEFEGELHNCVLVVQSFFDCDYPAALGIVDDLMASRMREF
                     EHIVAHELPVVCDDLGLDADARRDLDAFVDELRDWVSGILNWHRHCFRYDEESLRRHHR
                     RPEFRLGGPTGLGTSAALAYAGGLA"
     gene            complement(15713..16057)
                     /locus_tag="GBF35_RS49930"
                     /old_locus_tag="GBF35_49905"
     CDS             complement(15713..16057)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024857.5"
                     /locus_tag="GBF35_RS49930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBF35_49905"
                     /product="STAS domain-containing protein"
                     /protein_id="WP_193318293.1"
                     /transl_table=11
                     /translation="MSVVEERLLYQDRQLTITVRVAPGPPSVSLVGEIDASNSSAVAGA
                     LASCRQGGSVVVDTGRLGFVDVSGLRVLAMPGVPPSQRWIHLRNVTPYQRRLLLMMGWY
                     HEQRPHHLPA"
     misc_feature    complement(16104..16118)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.9"
                     /tool="antismash"
     misc_feature    complement(16136..16151)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 17.15"
                     /tool="antismash"
     gene            complement(16341..16607)
                     /locus_tag="GBF35_RS52125"
     CDS             complement(16341..16607)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="GBF35_RS52125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_193318292.1"
                     /transl_table=11
                     /translation="MMRRILAGAAIAGCLLGFSATSASADIGPNAYNGKQQILSQLSLI
                     DDATLLNDVLNDSVKYIDLGTIGHLQDIELDVLSNKSHTGDNN"
     gene            17002..17502
                     /locus_tag="GBF35_RS52130"
     CDS             17002..17502
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013073.5"
                     /locus_tag="GBF35_RS52130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="C40 family peptidase"
                     /protein_id="WP_194244084.1"
                     /transl_table=11
                     /translation="MVIGSAVHSVPALAARSAAGIIAVRAAIEMIGVPYTWGGGGVHGP
                     GYGIGKGAGTWGFDCSGLTEYAWAQAGVRIGTTTKEQWRSGIRIPKEQVEPGDLVFYDS
                     DTGSPGPEHVAIALSATRMVHAPYTGEFVRVDPLDRRTFLGVIRPGESGGKRHARRSGG
                     FPW"
     gene            complement(17717..17983)
                     /locus_tag="GBF35_RS49940"
                     /old_locus_tag="GBF35_49915"
     CDS             complement(17717..17983)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="GBF35_RS49940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GBF35_49915"
                     /product="hypothetical protein"
                     /protein_id="WP_139629711.1"
                     /transl_table=11
                     /translation="MIRRILAGAAIAAAALGFSATGASASIGPNPHNNGQSVLSQVSAL
                     DDLTALNDVLNDSVKYVDLLTFLHLQDIDASLLSNQEDVGDNN"
     misc_feature    18196..18211
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.35"
                     /tool="antismash"
     misc_feature    18248..18261
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.78"
                     /tool="antismash"
     misc_feature    complement(18249..18262)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.98"
                     /tool="antismash"
     gene            18394..18858
                     /locus_tag="GBF35_RS49945"
                     /old_locus_tag="GBF35_49920"
     CDS             18394..18858
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="GBF35_RS49945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GBF35_49920"
                     /product="hypothetical protein"
                     /protein_id="WP_153265458.1"
                     /transl_table=11
                     /translation="MRPRIRKTVMVIHVITSVALLGEVWGLVVLNTAAVLTKDTDLAHA
                     AYRLMPNLIFAGGIPLSLTALATGIALGLTSHWGLFRHYWVTVKLGLLVAVICVGIFLF
                     DPEGMAAATAGDAPVPGARGWGQITALGTQIAMLVTATTLSVFKPRRKLR"
     misc_feature    18875..18891
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 16.98"
                     /tool="antismash"
     gene            18890..19450
                     /locus_tag="GBF35_RS49950"
                     /old_locus_tag="GBF35_49925"
     CDS             18890..19450
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /GO_process="GO:0032259 - methylation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024967.5"
                     /locus_tag="GBF35_RS49950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBF35_49925"
                     /product="O-methyltransferase"
                     /protein_id="WP_153265459.1"
                     /transl_table=11
                     /translation="MSSTTPPLVTAALDRAGDFAHSCDPAVGRLLAALAAHVPQDGRVL
                     ELGTGVGVGLAWLASGLLPRTDATVTTVESDAERAARTATGDWPPFVRLLTGDALELLP
                     GLGTFDLVFADAVAGKQVGLDLTIAALNPRGMLVVDDMLPAPGAVWDDEFAARQDAVRR
                     RLLTHERLVAVELPHGVVLATAR"
     misc_feature    19514..19528
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 21.13"
                     /tool="antismash"
     gene            19557..20903
                     /locus_tag="GBF35_RS49955"
                     /old_locus_tag="GBF35_49930"
     CDS             19557..20903
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020540780.1"
                     /locus_tag="GBF35_RS49955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBF35_49930"
                     /product="methylation-associated defense system protein
                     kinase MAD6"
                     /protein_id="WP_139629708.1"
                     /sec_met_domain="Pkinase (E-value: 1.8e-17, bitscore: 62.8,
                     seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAEIVGGGRPVNDAERRVIAYLRDHAPADWLLLHNVEVPRGHDVF
                     EVDLIVLTGHSLVVVDVKGTRGRIEVSGTRWFPPRREAFGSPVAKLRGTAKALKGLLVS
                     KATQLDRVYVDSLVVLTSPDAELVDPAGRDAVNVTDLPGLLRTLSDVSRVRRGCSPDAK
                     PYLTAILDALNQTVRRSTAPPRFGNWEVEEQLGGDAKVTEYRAINVTLPGSETVLLRVY
                     QADPMADHDARAAERQRIANAYQTLARIPPHPCVVRSRDFFAIDDESRFVLVLDDVHGE
                     ALHLSLGRGAGLSVVQDLLRGLAHAHAHGVVHRALTPASVLVTDDGHAVLTGFDYAKPG
                     PRNYTVAHELGNVLDAHYVAPECQERPDRMTTASDVYAAGAIAHHVLTGRLPTSPDAQD
                     PEVPEVVRRMLDHTPAKRPTAAEALEALETAPVPESRLRRLVRRLVSRS"
     gene            20900..21406
                     /locus_tag="GBF35_RS49960"
                     /old_locus_tag="GBF35_49935"
     CDS             20900..21406
                     /EC_number="2.3.-.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111: GCN5-related N-acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009075302.1"
                     /locus_tag="GBF35_RS49960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBF35_49935"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_139629707.1"
                     /transl_table=11
                     /translation="MTAILRPVAEDDLPFMHRLTSDPDASGEFQWYGFQNPHRLRERWT
                     DNGMLSDDGGALIIANGDDRVGFVQWTKQVANRASHYWAMGLIVAPEHRGQGHGTQAQR
                     LLARYLFDHTTAHRIEASTEVTNVAEQRALEKAGFTREGVIRGSGFRAGEWRDGVRYSM
                     IRTDL"
     gene            complement(21495..22298)
                     /locus_tag="GBF35_RS49965"
                     /old_locus_tag="GBF35_49940"
     CDS             complement(21495..22298)
                     /EC_number="5.2.1.8"
                     /GO_function="GO:0003755 - peptidyl-prolyl cis-trans
                     isomerase activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012478.5"
                     /locus_tag="GBF35_RS49965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBF35_49940"
                     /product="FKBP-type peptidyl-prolyl cis-trans isomerase"
                     /protein_id="WP_139629706.1"
                     /transl_table=11
                     /translation="MRLFWPFMLVLATSCGVAEDGTQPVVTGAFGTKPVVAIPKGKPGR
                     TPRITVLSMGSGRRTLPGDVVLADVDIRRWSGNRPYMSTYDGNQPTSVVFDGRQVSDTW
                     RRSLIGRPAGSRVMLVSPAAEALGPNVPMTGLAPGDTLVLVFDILGGYPPDARLVGRTL
                     PVIPADFVPGSPPRTLIDGSGEEIAAGAKVVIQYVEAAWPSRAVVDSSYRRGGPSAFTL
                     AKGAVPDGWLGALVGRRVGSRVAVSCLGDRQSLYVIDVLDTFTHV"
     gene            22585..23616
                     /locus_tag="GBF35_RS49970"
                     /old_locus_tag="GBF35_49945"
     CDS             22585..23616
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020540782.1"
                     /locus_tag="GBF35_RS49970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBF35_49945"
                     /product="DUF2293 domain-containing protein"
                     /protein_id="WP_153265460.1"
                     /transl_table=11
                     /translation="MSKPNLARRVAEAAEIALTTRKYVTFIDVVTGLRWLHSRHVDTWR
                     QGRAATLAELAAVDEDRLLATAALLKEWALAKGLRPVDTPYVAGTRDRRELRFTAAHGQ
                     EPFRVHWLSPDLSEARVRRLTEAKVPDLVAVAPLDAWTCASCGDTGPYLIVEDDSPHCL
                     TCADLDHLVFLPSGNAALSRRAKQESGLSAVVVRFNRRRKVYQRVGLLVEEGALAAAEE
                     RCLADEEVRLRRRERDRERRAEQDVEFQARMAAEIARLFPGCPAERATEIAEHAAQRGS
                     GRVGRSAAGRALDEGAITLAVIASIRHLDTDYDRLLMSGVPRMEARDLVRERIEGKLEE
                     FRR"
     gene            23613..23999
                     /locus_tag="GBF35_RS49975"
                     /old_locus_tag="GBF35_49950"
     CDS             23613..23999
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016152.5"
                     /locus_tag="GBF35_RS49975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBF35_49950"
                     /product="MmcQ/YjbR family DNA-binding protein"
                     /protein_id="WP_139629704.1"
                     /transl_table=11
                     /translation="MSDWHDVRERLRAYALGLPETHEDHPWGETVIKVNKKVFLFLGLD
                     EQTEKWDPTFGVKLVSEAHGHALTVEGAAPSSHGLGRAGWVTVPFLSELPETDVLLDWV
                     EESYRAVAPRRAVKELDERPPGLR"
     gene            complement(23992..25218)
                     /gene="kynU"
                     /locus_tag="GBF35_RS49980"
                     /old_locus_tag="GBF35_49955"
     CDS             complement(23992..25218)
                     /EC_number="3.7.1.3"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_function="GO:0030429 - kynureninase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006569 - tryptophan catabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0009435 - NAD biosynthetic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_5 (149-342). E-value: 1.4e-18.
                     Score: 58.9. Matches aSDomain:
                     nrpspksdomains_GBF35_RS49980_Aminotran_5.1"
                     /codon_start=1
                     /gene="kynU"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139: aminotransferase class V"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012895457.1"
                     /locus_tag="GBF35_RS49980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBF35_49955"
                     /product="kynureninase"
                     /protein_id="WP_153265461.1"
                     /sec_met_domain="Aminotran_5 (E-value: 5.9e-14, bitscore:
                     51.0, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGRRNRTTGETVDREQCLALDAADPLRAFRDEFVLPEGVVYLVGN
                     SLGALPRRTPERVRQAVEDEWGGQLVGGWNHSGWYTQPLTTGDRLAPLIGAGPGQVVVG
                     NTTSIAIFQAVAAALRLRPERRVIVSDVRNFPTDHYMVQGLAGLLGGYEVRDLAEGRFD
                     DAAVVLLSEVDYRTGARHDVPSVTARAHEAGALMIWDVCHSVGAMEVDVSEADFAVGCT
                     YKYLNAGPGAPAFLYVNPRHHADAQNVLSGWHAHAEPFAFEAGFRPAEGIRRFAVSTPH
                     VLSFAALEAALDVWERVPMDQVRAKSMALTSLFVDLVGDALELVSPADPAARGSQVSLR
                     HPDGYPVMRALIDRGVHGDFRAPDILRFGFAPLYIRYADVHDAAATLLDVLDKELWKDE
                     RYATRLAVT"
     aSDomain        complement(24193..24771)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_GBF35_RS49980_Aminotran_5.1"
                     /evalue="1.40E-18"
                     /label="GBF35_RS49980_Aminotran_5.1"
                     /locus_tag="GBF35_RS49980"
                     /protein_end="342"
                     /protein_start="149"
                     /score="58.9"
                     /tool="antismash"
                     /translation="GGYEVRDLAEGRFDDAAVVLLSEVDYRTGARHDVPSVTARAHEAG
                     ALMIWDVCHSVGAMEVDVSEADFAVGCTYKYLNAGPGAPAFLYVNPRHHADAQNVLSGW
                     HAHAEPFAFEAGFRPAEGIRRFAVSTPHVLSFAALEAALDVWERVPMDQVRAKSMALTS
                     LFVDLVGDALELVSPADPAARGSQVSLRHP"
     misc_feature    25298..25317
                     /note="TFBS match to DosR, Hypoxia stress response
                     regulator, confidence: medium, score: 24.36"
                     /tool="antismash"
     misc_feature    25548..25562
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.92"
                     /tool="antismash"
ORIGIN
        1 ccgtccgtac tcggcgaggg cgacggcgac gtccacctgc gcccagaacc ggtggtagtt
       61 gaagacgggc gcggggcccg tgccgttgag gtaggcgctg acctccggcc aggcggggtc
      121 gtcctcgtag aacgacctga tcgagatgaa ggtcgagtcg gagttgatcg ggtcgccgtt
      181 cggcatctcg ccggtccagc cgtcgggcac gtagaccggg tcgtcgatac ggctgtagtc
      241 ggtcttggtc tccgggacgg acacgccctc ggcgtcgcgg tgctgccaga cgccgtcgag
      301 cagcgccttg gccatgtccc gcgcgtccgt gtcgttcgcc ttggccgcgt agtacatgag
      361 cgccttggcg tacgcgccgg ccacgcccac gtcgttcgtg tagtcggcga tcgtcacgtg
      421 caggcccggg ttggccggcg gcatgcccga gttggcgctg aagtcgccca cgggctgccc
      481 ggtccaccgc agcgtggacg ggatctggta cgagccgtcc gcgttgatgg tggtgttgtc
      541 catcgcccag ccgacccact tgtcgagcag cgccttcgcg tcggcgttgc ccgacgcgta
      601 gtacagctcg gccacccgct ccatcgtcca cgcctggaag ccgaaccact ggttcgacgg
      661 cgggtcgtgg tagacgggct gccagtcgta ggtcaggccg tggaacttcg gcaggccgct
      721 cggcggcgtc gcgtagtggc cctcccagct gttggtcgcg ccaccggcga tggcgccctc
      781 ggccgactgc agccagccgt agaactgcaa ctgcctggtg aggctggtgc tccagtcggt
      841 caccgcgctg ctgctcttgg gcttcagctc ggtcacgttc gacagcgccc aggccgcgag
      901 cgggttctgg taaccggagt ggttgtggct ggagccgatc cgccacgccc agccggcgct
      961 ggagtcggtc gcgccgcccc aggcgtagta ccagctcagc aggtagttgg aggcgtcctt
     1021 gccggtgccg gccgcgcacg acgtgctcgt gcagccgggc ttcttgaagt acttgtcgta
     1081 catcgcgtag cgcaggtagt cgcccatctt cgcggccttg ccgaccgacg cggagatctg
     1141 cgactccttg ccctgggcct tggcccacgt ctgcgcccag tacgcggcct gcacggcccg
     1201 ggcgtcggcg tcgggggcgt tggtgtactt ccactgcttg gcgtaggagg cgtccttggt
     1261 gaacaggtcc aggtagccgt tgggcccgcc gaacgcgaac gtgtcgcagg acggctgcgg
     1321 aatcgtctcg aagaccgact cctcggggcc gcgctggtag gtgttgatgt aggcgggcct
     1381 ggtggtgccg tcgccgcagt ggccgaagcc gtaggtgttg tcgacgtcga gcagccagtg
     1441 catgccgtag atgtcaccgg tgccgtacgc gctcttcagc tcgttggcca gcgggtcctg
     1501 gcccacgctt actccggtgt cgagctgcga cgggtagtcg ctgatgtcgt tcgactccgg
     1561 cgcgtacgtg gccggcttgg acggcgtgta gaaggagttc gtcggctggt cggcgctgga
     1621 cgggatgatg tacttctcca tcgaggccca cgcgtcgttg aacttcgacc agtcgccggt
     1681 gacctgcccg tagaccgcct ccagccacag gtagtagctg taggcctcgg acgtggtctc
     1741 gtgcccgtgg tccggtgcct cgaccatgaa cgtctcgatc gagtggtacg gcacgccctc
     1801 gggcgagaag tagccgttgg ccgggtcgtg gatctcgttg tagagctcga cgaagcgctg
     1861 gacgtactcg ttgtcgccgc cgacgtcgtc gtccgcctcg gtggcggtca cgttgacggc
     1921 ggtgtagccg gtggcgctca ccctgaacac ggccgttccg gaggtcgtgt cggagtcctg
     1981 ggccgccgag agcgtgacgt tctgggcggt gttccagttg gacggcgtga acgtccggct
     2041 ggcgccggcc gagacgctga ggtcgctgtc accgctcgtg cgcgccgtgg tcacggtcac
     2101 gttggaggac ggcgcctgcg acagcttgac ggtgacgttc gcgtccccgc cctccggcac
     2161 ggacacgctc gccgggctca ccacgagcga ggggcccgtg ttctgggaga ccgtgatgcc
     2221 gaccggcgcc gaggtggtgg tcgcgccgcc gttgtcggtg gcccgcgcgg tgatcgagta
     2281 gctgcccgcc gccacgccgg tccagctgta gctgtacggg gccgaggtgt cgctgccgag
     2341 cagcgtggag ccctggtaga agtcgacctt ggagaccgag ccgtcggagt cggaggcgtt
     2401 cgccgcgatg gccacggtgg ccggggcggt gaacgtctgc cccgcggtcg gcgaggtcag
     2461 cgagactgag ggaggcgtgt tggcgccgcc acaagaggtg ccgttcacgc tgaacgaggt
     2521 ggggttcggg ttgctgccgg tccaggtgcc gttgaagccg atcgacgtgg tggcgccggt
     2581 ggccagggtg ccattccacg gcatgttggt ggcggtcacg cgggtgccgg actggctcca
     2641 gttcgcgccc cagccggacg gcgtgtactt ctggcccgag gtcgggaagt cgaaggccag
     2701 cgtccacgac gtgatcgggt caccggtgtt cttcagcgag atgttcgcgg tgaacccgcc
     2761 ctggccgggg ctgctcgtcc aggagttggc gttgtacgtc acgtcgcacg ccacggccgc
     2821 ctgggcggga gcggcggtca cggccgcggt cgcgctcgcc acgaggacga gcgcggccgc
     2881 caccgagagg cgtctcgata agcgggtgag tagggcagga ggtctgtgcg tcacgggatc
     2941 tccatgggat cggaagggag tgggagcgct cccaaaccga agtgtgggtg cctgcccgcg
     3001 tatgtcaacg gaatggcgtc cccgtaacac ccgcatttcc tctctaccag gctccccggg
     3061 atgaaagttt catccccgtt cgggggcatt cagcgagcat gcggggcggc ggacgccctc
     3121 cggaacgccg ggctctgtac agggatgcgg gcacggcaga ccatgggagc gctcccagcc
     3181 ccctagcact ggagatgatc gctcgtgaga ctccaacgcg gccttcaccg atgggccgtg
     3241 accgtgacgg ccgcgagtgt cgcggccctt gggctcgtcg tgggccagag cacggccgcg
     3301 aacgccgcgg ccggctgcga cgtgacctac tctgccaact cgtggacgag cagccccggc
     3361 cagggcggtt tcaccgcgaa catcacgctg aagaacaccg gtgacccgat cagctcgtgg
     3421 acgctggcct tcgactaccc gacctccggt cagaagtaca ccccctccgg ctggggcgcc
     3481 aactggagcc agtccggcac ccgcgtgacc ggcacgagca tgccctggaa cggcagcctc
     3541 tcgaccggcg cctccgtctc cgtgggcttc aacggcacct ggtccggcac caacccgaac
     3601 cccacctcgt tcagcgtgaa cggcaacacc tgcggcggcg tcaacccgac caccccgtcg
     3661 gtggtcacct cgcccagctc cgtcgcggtg aacgagggcg gcacggccac gttcacggcc
     3721 aagctctcct cggccccgtc ctccaacgtg accgtcacca ccacccggac cagcggtgac
     3781 accgacctgt ccgtcagcgc gggcggctcg ctgaccttca ccccgtccaa ctggaacacc
     3841 gcccagacgg tcaccctggc cgccgcccag gactccgaca ccaccgcggg caccgcctcc
     3901 ttcaccgtcg gcggcaccgg cgtcacggcg gccacgctct cggccaccga ggtggacgac
     3961 gacgccgtgg tcgagcagtc gatcatcgtc acgccgacct cggtcaccgt gccggagggc
     4021 tccaccgcca cctactccgt gcgcctggcc acgcagccca gctccaacgt gaccgtcacc
     4081 tcgacggcgg gcagcggcga cgcgaacatc accgtctcca gcggcgcgag cctcacgttc
     4141 acgtcatcca actggaacac cgcgcagacg gtcaccctgg ccgccgcgca ggactccgac
     4201 acggccaacg gctcccgcac gatcaccgtc gcctcctccg gcctgacctc caggaccgtc
     4261 accgccaccg aggccgacga cgacgacacc ggcacccccg gcggccacgt cgagaacccg
     4321 tactcaggcg ccaccggcta cgtcaaccct gactggaagg ccaaggccca ggccgagccc
     4381 ggcggctccg cggtggccaa cacctccacg gccgtctggc tcgaccgcat cgccgccatc
     4441 gagggcgcca acggcgccat gggcctgcgc gagcacctgg acgaggccgt caggcaggac
     4501 gccgccaacg gctccacgcc gctgaccgtg cagttcgtca tctacgacct gcccaaccgc
     4561 gactgctcgg cgctggcctc caacggcgag ctgcgcatct ccgagaacgg cttcaaccgc
     4621 tacaagaccg agtacatcga cccgatcgcg tcgatcatga gcgactccgc ctactcgaac
     4681 ctgcgcatcg tcaccatcat cgagccggac tcgctgccca acctgatcac caacatcaac
     4741 aagttcgcgg actgccagga ggccaacggc cccggcggtt acgtggacgg cgtgcggtac
     4801 gcgctgaaca agctgcacgc tatgagcaac gtctacacct acatcgacgc cgcccaccac
     4861 gcctggctcg gctgggactc gaacttcggc ccctcggtcg acctgttcta caacaccgtg
     4921 tccggcacca ccgccggggt ggacagcgtg gacggcttca tcgtcaacac cgccaactac
     4981 tccgcgacca ccgagccgta cttcacgatc aactcgaccg tgaacggcca gtcggtccgg
     5041 cagtccaagt gggtcgactg gaactactac gtggacgaga agaccttcgc cacggccctg
     5101 cgcagcgcgc tgatcggcaa gggcttccgc caggggctcg gcatgctgat cgacacctcg
     5161 cgcaacggct ggggcggcag cgcccgcccg tccgggccga gcacctcgac caacgtggac
     5221 gagttcgtca acgactcgcg cgtcgaccgc cgcatccacg ccggcaactg gtgcaaccag
     5281 agcggcgccg gcatgggcga gcggccgacc gccagcccgg ccgccggctt cgacgcctac
     5341 gtctggatca agcctccggg cgagtcggac ggctccagcg aggagatcga caacgacgag
     5401 ggcaagaggc tcgaccggat gtgcgacccg acgtaccacg gcaacgagct gaacggcaac
     5461 aacctgacgg gtgcgctgcc cgacgccccg ctgtccggaa ggtggttctc ggcgcagttc
     5521 cgcgagctgc tcgcgaacgc ttacccgccg atcaactgaa cccgcctcaa ccgaccgggg
     5581 gccggcttcc ggcccccggg cacgagcccg agcgacccgc ctgacccggg tctctcggag
     5641 gggcccgcct gacccgggcc cctcgaccac ccgaaggggc cccctgcgcg gggccccttc
     5701 gcctgtttcc gctatttgcg cgcctggcgc cactccgaga cgatctcgtc ggcgtcgaag
     5761 ggcatgaggt tgagcggcgg gccggacagc ccggtcctga tcgcctcgcg gatcttctgg
     5821 ttgatctcct cgacgatccg ccgcgcctcg gtctccgacc tcgccccgcg cgcctgggcg
     5881 agcgcctcct cggcctcctt gcgcagcgcc agcgtgggcg gcaggggcat cgacagcccc
     5941 tcgctctcga ccttctgctt gatccaccac atgtcgtcgt gcggccggtc gagccccggg
     6001 atcggcttgc cggcacacgg caggtcgtcg aacgcgccgc gctcctccgc ctcgcggatc
     6061 tgccggtcca cccagctctc gaacggcatg cccagtggtt tccgctcggt caaaggacct
     6121 cctcaggcaa ggttgtgact cggggtcagc gggccacgcc agccgagcat ggcctcggtc
     6181 atgcgtacgg acgcgaccgt ggcggccacg tcgtgcaccc gcaggatgcg ggcgcccttg
     6241 acgatgcaga agacgttggc ggcgatggtg ccctccttcc gctccccctg ggggcggtcg
     6301 agcgtctccc cgatgaagtc cttgttggac agcgccacca gcgtcgggtg gccgatcgcg
     6361 gtgacctcct ccagccggcg ggtgatctcg agcgagtgga aggtgttctt gttgaggtcg
     6421 tggccggggt cgatgatgat cttgtcttcc gcgatgccgc acttcagcgc gtacgcgacc
     6481 cgctcgcgca gatagtcggt cacctcggag accacgtcgg cgtagctcgg ccggaagacg
     6541 cgcctgccgg ggccgcccag gctgtgcgtg acgatgacgc tggcccccga ctcggcggcg
     6601 aactcggcca tgccgggctc gcgcaggccg ttggtgtcgt tgatcacgtc ggcgcccgcc
     6661 tcgaccgccg cccgcgcgac ctcgggccgg tgggtgtcga cggagatgac ggcgtcggtg
     6721 acctcgcgca cctcggcgat caccggggcg acccggtcga tctcctcgtc cgctccgatg
     6781 cccgcctggg ccgcgctgaa ggcgaacccg ccgatgtcga cccagtcggc gccgtcgtcc
     6841 acggcccggc gcgcggccgt gacggcgctg tcgagctcga acgtgcggcc ctggtcgtgg
     6901 aaggagttgg gggtcctgtt gacgatggcc atgatggcga cctggcgcgc gaagtcgaac
     6961 tcccgccgcc cgatgcgccg gacaggcgag atgatctccg ggggaagcgt ttcgccgctc
     7021 acatggtgag cctacctgcc acttgtccag ggccgtcgtc ccgcccgcgc ggcagccgca
     7081 tggcgagccg gaccgtggtg ccgtccgggc cggtgtcgaa gtcggccgtg tcgcacaacc
     7141 ggcgcatcag gtagatcccc ctgcctctct gggccaggcc gggcggctcg cggtcggcgg
     7201 ccatgtagcc gtcggggatg cccgtccccc ggtcgctcgt ctccgagccg atcacgccgt
     7261 cggccgtcca cagcctgaag tagccgtacc cgcccgcgtg ctccacgacg ttgacgacgc
     7321 tctcgtgcac ggccagcacg aagtcgtcga gccgggggcc gaccagcccg cggccgccgg
     7381 ccaggtcggc cacggcgcgg cgcagcctgg tgacgtcctc aagggtgaag ggctgggcca
     7441 tcagggtgcg catgcgctcc tccgtgtcgg tccgacacac aggccgccgc tccatgaccc
     7501 cgggcgggcg tctcagggac gcgcgcccac cccgccggcc agttccttgg cgcgttggac
     7561 cggcccgccg tcgggagcga gcggcgcggt gtccatgccg gcgccgtcgt gcagcccctg
     7621 gaagagctct tgcatggcct cccacgacga gtgccgcggc gtccagccga gcacctcgcg
     7681 ggcccgctcg gtgttcatgt acgggatctg caggaccagg tcgagcatcg acggcgcggc
     7741 cgggatgagc ctcaggtgcc atcctgccga catgaccgcc ctggccaggc ccgccgggac
     7801 ccgcaccgtg cgggcgccga gcagcttggc caggtcgggc gggtcgagca cgggctcggc
     7861 ggcgatgttg aacgggccgc gcacgtcctt ggtgacggcc agccggtacg cctccgccgc
     7921 gtcctcggcg tgcagcacct gcagccgcag gccggggatc tccggcacga acgggacgcg
     7981 cccggccctg atcagccgcc gcggcacgaa cggcccgccg aacagcctgc gctgctcggt
     8041 ggacgccgcc cgctggaaga tgaacccggg ccgcatccgc accacccgga tgcccggatg
     8101 gtcgttctcg aacacgtcga gcacccgctc gacgtacgcc ttctcccgcg cgtacgcggt
     8161 gcccggccag ccgtgcgtgg gccagctctc gtccaccggc cggtccttcg gccccgggga
     8221 gtacgccccc acggacgagg cgtggaccaa tgcgggcacc cccgcctccg cgaccgcgcg
     8281 gaagacgcgc atgctgccca gcacgttggc ccgccaggtg gtggccgggt gcctggtcgg
     8341 ctggaacagc cacgcgaggt gcacgaccgc gtcggccccg tcgaagatgc gcgtcaggtc
     8401 ggcggtggcg acgtcggcct gccgccagtc ggtgcggtcg atccgccatc ggggcagccg
     8461 gcgggcgacc ccgacgatcg aggtcacgcc gccgtccgtg gccagcgcgc gcaccacgct
     8521 ggtcccgacg ttgccggttg ctcccaccac gacgactctc atggaagcac cgctgcccgg
     8581 ccgccgggcc acgaaacccc tcccacctgc caggtcatgg ctgcagcacg atcttgatcg
     8641 cgccgtcctt cttccgctgg aacatctcgt acgcctccgg cgcccgctcc agcggcatgc
     8701 ggtgggtggt caggtccatc acgccgagcg gatcggactc gtcggtcacc agcggcatca
     8761 gcgcggaggt ccacttcctg acgtgggcct gccccatgcg cagcgtgatc cccttgtcga
     8821 acatgcgcag catgggcatg ggatccgtca tgccgccgta gacgccgatg atcgagatga
     8881 cgccgccgcg ccgtacggag tcgatggact ggttgagcgc ggccatccgg tcgacgcccg
     8941 tgtgcgtcat cagcggcgcg gcgacggcgc ccggcagcat gccggtgagc gtctgggcga
     9001 gcttggcgcc gagcgatccg tgggcctcca tgccgaccgc gtcgatgacc gagtcggtgc
     9061 cgcgccccga ggtgcgctgc ctgatctcct cgggcacgtc ggtgacctcg ctcgcgtcga
     9121 cgacgtcgat gccgtggcgg cgggccatct ccaggcgctt cgtgacgccg tccacgccga
     9181 tcacgcggtg gccgaggtgg gcggcgatgc gggcgcacat ctggccgatc gggccgaggc
     9241 cgtagacggt gacgctgccg ccctccggga tgtccgcgta cgcgacggcc tgccaggcgg
     9301 tgggcagcac gtcggacagg aacaggaacc gctcgtccgg cccgccctcg ggcaccttga
     9361 tggggccgaa ctgggcctcc ggcacccgga ggtactcggc ctggccgccg ggcacctggc
     9421 cgtagagctt ggtgtagccg tacagcgcgg cgccggtgcc ctgctcgcgc acctgcgtgg
     9481 tctcgcactg ggcgtagagc tccatcgagc acatgtggca gtgaccgcag gaaatgttga
     9541 acgggatgac cacgcggtcg cccggcttga tggtgtcgac cgcggggccg acctcctcga
     9601 cgacgcccat cgcctcgtgt ccgatgatgt cgccttcggc catgaacggc ccgagcacct
     9661 cgtacaggtg caggtcggag ccgcagatgc cggtgctggt gaccctgatg accgcgtcgt
     9721 tgggctcctt gaccgccggg tcggggacgt cctcgacccg tacgtcgcgc ttgccgtgcc
     9781 aggtgactgc cttcatggtg tctccttacg gacgggggca caaagggcgc atacccctac
     9841 atacggcatc aaacgggcga ccacccttcg gcggccgcgt ctcggtgtgg ccgctgtggc
     9901 aaaagaaatc gcctgaccac aaaagactct ttacacgctg cgtattgaat gagtaactac
     9961 tggtagcgaa cgcccgacag aaggagccgc gcagatgccg gtgagcttca ctcagcacga
    10021 cgttggatcg cgcgttgacc ggcgcctggc cggcttcctc gagacctggc gcgcccctgt
    10081 cgacgacccc gacgtcgagg cggcttaccg gttgctgacc gacttcatcc tccgcggcgg
    10141 caagcgcgtc cggccgcggc tgtgctactg gggctggcgc ggcgcgggcg gcgacgacag
    10201 cgaggagatc atcaccgccg cggcggccct ggagctgtgc cacgccggcc tgctcatcca
    10261 cgacgacatc atggacggca gcgagctgcg gcgcggccgg gtcaccgtgc acaggagcct
    10321 cgccgggctg caccacggtc ccggcgcgga gatgttcggc caggcgggcg gcatcctgct
    10381 cggcacgctg agcctcgcgt ggtccgacac gatgctgtcc tcgtgcgggg tggagccgca
    10441 ccggctgcgc gccgcgcacc acgtgttcga cgccatgcgc accgaggtca tcagcggcca
    10501 gtacctcgac gtcctggccc agctgcgcgc gggcgcgagc gtggccgagg cgctcacggt
    10561 gatccggttc aagaccgcca agtacaccgt cgagcggccg ctgcagatcg gcggcgcgct
    10621 ggcgggcgcc tcgatggagc tgctggagtc ctactcccgc ttcggcctgc cgctgggcga
    10681 ggcgttccag ctgcgcgacg acgtgctcgg cacgttcggc tccgagtcgg agaccggcaa
    10741 gtcggcgctc gacgacctgc gcgagggcaa gcacacggtc ctgttcgcgc acgccgtgcg
    10801 caaggcctcg cccgcccagc tccgccacct caggagatgg cacggcaatc cggagctgac
    10861 cgaggagcgc gccgaggagg tgcgcgagat cctgcgcgac acaggagcgc tggccgaggt
    10921 cgagcaaatg atcgaagagc gggtgcacga ggccgtgacg gcgctgtcgg ccgcgcggat
    10981 ggagccggag gcagccaagg cgctgaccct gatggcggac cggctggcgc accgcaccaa
    11041 gtagggggtt ttccagatgg cacgggttct tctcgcggcc ccgcgcggct tctgcgcggg
    11101 tgtcgagcgc gcgatcgcca cggtcgagca ggcgctgagc cgcttcggcc caccggtcta
    11161 cgtgcgcaaa cagatcgtcc acaacacgta cgtggtcggc gacctcagcc ggctcggcgc
    11221 gatcttcgtc gaggagctcg acgaggtgcc cgacggctcg ctggtcgtct tctccgccca
    11281 cggcgtctcg ccggcggtca aggaggaggc ggagcggcgc ggcctgcgca cgatcgacgc
    11341 cacctgcccg ctggtcacca aggtgcacaa ggaggccgtg cgcatggccg aggagggcta
    11401 cgagatcgtg ctcatcggcc atgccgacca cgaggaggtc gagggcacct acggcgaggc
    11461 ccccggccac atccacgtcg tcgacccggc ccggcccggc gaggtgacgg cgaaggggcg
    11521 ggtgagctgg ctgtcgcaga ccacgctgtc cgtcgacgag accatgcggg ccgtcgccga
    11581 gctgcgcgag cgcttccccg acatggccga cccgcccagc gacgacatct gctacgccag
    11641 ccagaaccgc caggaggcgg tcgccgcgat cgccccgcgg tgcgagctgg tcatcgtcgt
    11701 cggctcggcc aactcctcaa actcccggcg gctggtcgag gtggcgctcg gcgcgggcgc
    11761 ggacgcggcg cacctggtcg accgggccga cgacgccgac gagcggtggc tcgccggcgt
    11821 gcaaaccgtc ggggtcacct ccggcgcctc ggtccccgac cggctggtcg gggagttact
    11881 cgactggctc gccgcacgcg ggttcaccga cgtggagccg gtgaccctga ccgaggagac
    11941 cctcacgttc tcgctcccgc ccgagatccg atccacccgc aagtacggct aggtccccta
    12001 ccgagattgg tggtgcagca cgatgaccga aacgaccaac tcacccgccc ctgagaccgt
    12061 caacggcaac ggacagctca gcctcagcac cgaggccgcc agacagctct cgaccacgac
    12121 caagacgccg ccgcagatgc aggagatcac ctcccggtgg ctgctgcggc tgctgccgtg
    12181 ggtgcagtgc tcgggcggcg tgttccgggt caaccggcgg ctcacctacg agctgggcga
    12241 cggccgcatc accttcagca acaccggctc gaacgtgcgg gtcatccccg ccgagctgac
    12301 cgagatcccc atgttgcgcg gcttcgacga cgcggaggtg ctgcaggcgc tggccaacgg
    12361 cttcgcgcag cgggagatcg aggcgggcga ggagatcgtc tccgagggcc gtcccgtcga
    12421 ccggctcgtg ctcatcgccc acggccgggt ggccaaggtg agccgcggcg cgtacggcga
    12481 cgagcagaac ctcggcgtcc tggccgacgg cgactacctc ggcgaggaga ccctgaccca
    12541 gggcggccgc tacgcgttca ccgcgcgggc caagacggcc accaccgtcc tcaccctgtc
    12601 cagacaggac ttcgagcagc tcgccgacca gtcacccggg ctgcgcgagc acctcgaccg
    12661 ctggctcgcc agcggcgacc acgcccagaa cgactacggc gaggccgcga tcgacgtgtc
    12721 gtccggccac accggcgagc ccgtgctgcc cggcacgttc gtcgactacg agctgagccc
    12781 ccgcgaatac gagctgagcg tggcccagac cgtcctgcgc gtccacagcc gggtctccga
    12841 cctgtacaac cagccgatga gccagctcga ccagcagctg cgcctcacga tcgaggcgct
    12901 gcgcgagcgg caggagcacg agctgatcaa caacaaggag ttcggcctgc tccacaactc
    12961 cgccctcagc cagcgcatcc gcacccgggc gggccggccc acccccgacg acctcgacga
    13021 cctgctggcc accgtgtgga aggacccggc gttcttcctg gcgcaccccc aggccatcgc
    13081 ggccttcggc agggagtgca gcaagcgcgg cgtctacccg cagaccagtg aggtcaacgg
    13141 gcaccgggtg ccgacctggc ggggcgtccc gatcttcccg tgcaacaaga tcccgatctc
    13201 cggcacgtac acgacgtcgt tcctgctcat gcgcaccggc caggagaacc agggcgtcgt
    13261 cggcctgcac cagaccggca tccccgacga ataccagccc agcctgtcgg tgcggttcat
    13321 gaacatcaac gagaaggccg tcatctccta cctcgtcagc gcctactact cggcggccgt
    13381 gctggtgccg gacgcgctcg gcgtgctgga ggacgtcgag gtcggcagga acggctgaca
    13441 ccgggatccg cacaggccgg caccgcgcgc tcggtgccgg cccgcgtacg cgaggagaga
    13501 tattgagcca gccctttgaa ctgcccgact tctacatgcc gtacccggcg cggctgaacc
    13561 cccatctcga agcggcccgg gcgcactcca ggcagtgggc gcgcgacatg ggcatgctgg
    13621 acgaccccgg cgtctgggag gaggccgacc tcgactccca cgactacccg ctgatgtgcg
    13681 cctacaccca tcccgactgc gacgccgccg agctgtgcct catcaccgac tggtacgtgt
    13741 gggtcttctt cttcgacgac cacttcctcg aggcgttcaa gcgctccggc gacctggcgg
    13801 gcggcaaggc gcacctcgac cggctccccg ccttcatgcc gatgggcggc gacctgagca
    13861 tgcccgagcc ggccaacccg gtcgaggcgg gcctggccga cctgtgggtg cgcacggtgc
    13921 cgagcaggtc cggcgactgg cgggcccgct tcgccgagag cacccgcaac ctgctgaacg
    13981 agtcgctctg ggaactgcgc aacatcaaca cggggcgggt gtccaacccg gtcgagtaca
    14041 tcgagatgcg ccgcaaggtc ggcggcgctc cctggtcggc cgggctggtg gagcacgcgg
    14101 tgggggccga ggtgcccgcg cggatcgccg gcagccggcc gatgcgggtg ctgaaggact
    14161 ccttctccga cgcggtgcac ctgcgcaacg acctgttctc gtacgagcgg gaggtcggcg
    14221 acgagggcga gctgagcaac ggcgtgctgg tgctggagac gttcctcggg tgcggcacgc
    14281 aggaggccgc gaacgcggtc aacgacctgc tgacctcgcg gatgcagcag ttcgagcaca
    14341 cggcgctcac cgagctcggg ccgctgttcg tggagcacgg cgtcgacccg atcagtgcgg
    14401 ccggcgtgct ggcctacgtc aaggggctgc aggactggca gtcgggcggg cacgaatggc
    14461 acctgcgctc cagccggtac atgaacaagc gcgccaccgc gagccggccg ctgggcatgt
    14521 cgtccgtcac cgacctgctc ggggccaagc ggctgcgcgc cttcacccac gtcccgcacc
    14581 agcgcgtggg gccgtcgcgg atccccgacc tgtacgtccc gttccagctg cggctctccc
    14641 cgcacctgga cgcggcgcgg cgggacaccg tggcgtggtg ccgggcgatg ggcctgctcg
    14701 acacgggcgt gtgggacgag cggcagctcg tcgacatcga cctgccgctg tgcgcggccg
    14761 ggctgcatcc cgacgccggc cccaaggagc tggccctggc ctcgcactgg ctggcctggg
    14821 ggacgtacgg cgacgactac ttcccggtcg tcttcggccg ctcgcgcaac ctcgcggcgg
    14881 ccaggatcgc ggtggagcgg ttctcgggct gcatgccgct ggacggctcc cccgcaccgc
    14941 cgcccgccaa cgcgatggag cgggccctgg ccgacgtctg ggcgcgcacc gccgggccga
    15001 tgccgccgga gcaccgccgc gagctgcgct ccgcggtcga gagcatgtgc gagagctggc
    15061 tgtgggagct ggccaacgag atcgcccacc gcatccccga ccccgtcgac tacgtggaga
    15121 tgcgccgcag caccttcggc tccgacctga cgatgagcct ggcgcggctg cggcacggcc
    15181 ggaggatccc ccgcgaggtg cacgacagcg gccccatgcg ggcgctggtg agcgccatca
    15241 ccgactgcgg cacgctgatc aacgacatct tctcctacca gaaggagatc gagttcgagg
    15301 gcgagctgca caactgcgtg ctggtggtgc agagcttctt cgactgcgac tacccggcgg
    15361 cgctcggcat cgtggacgac ctgatggcct cgcgaatgcg ggagttcgag cacatcgtcg
    15421 cgcacgagct gccggtggtc tgtgacgacc tcggtctcga cgccgacgcg cggcgcgacc
    15481 tcgacgcgtt cgtggacgag ctgcgcgact gggtgagcgg catcctcaac tggcaccgcc
    15541 actgcttccg ctacgacgag gagtcgctgc gccgccacca ccggcgcccg gagttccggc
    15601 tgggcgggcc gaccggcctc ggcacctccg cggccctggc ctacgcgggc ggcctggcct
    15661 gaacggacag cctcgcctct acgggcagcc ccgcctctac gggcagcctc gcctacgcgg
    15721 gcaggtgatg ggggcgctgc tcgtggtacc agcccatcat gagcagcaac ctccgctggt
    15781 acggcgtgac gttgcgcagg tggatccacc gctgtgacgg cggcacgccg ggcatggcca
    15841 gcacgcgcag gcccgagacg tcgacgaagc cgagcctgcc ggtgtcgacg acgacgctcc
    15901 cgccctggcg gcaactcgcc agggcgccgg ccaccgcgga actgttggag gcgtcgatct
    15961 cgccgaccag cgagaccgag ggcggtcccg gcgccacgcg cacggtgatc gtcaactgcc
    16021 tgtcctggta gagcaggcgt tcctcgacga cgctcacgct cctcacaccc cccaacgcgc
    16081 acattctggg ggttgtcatc ctgcatctgc tgaaaaacca gattacacga agtatgtttc
    16141 gctatgtaat tttcgccgga aaatgaccga attacgggga aataatgaag ggcacggcta
    16201 tgccgtgccc ttgaccccac gcccatgagg cgcccgccgc cgcggcccgt ccgggaggcg
    16261 cgctccgaca aggtgccgcc acgtcaccgt ggctgccgga gcgccttcag gtcaggccgg
    16321 gagcgaccgc ccgcggtggc tcagttgttg tcgccggtgt gggacttgtt gctgagcacg
    16381 tcgagctcga tgtcctgcag gtgaccgatc gtgccgaggt cgatgtactt caccgagtcg
    16441 ttgagcacgt cgttgagcag cgtggcgtcg tcgatcaggc tgagctggct gaggatctgc
    16501 tgcttgccgt tgtacgcgtt ggggccgatg tcggcggagg cgctcgtggc cgagaacccg
    16561 agcaggcaac ccgcgatcgc tgcaccagcg agaatgcgac gcatcatttt cttgtttctc
    16621 cttcgtcgga attggcgcgg gatgcgcgtc atcgtgaatc cctcgcagcc ggctgcgaga
    16681 tttcaggaat tacactctcg cggcctgtcc acgggtcgca acccgactgt gccaatcctc
    16741 agtcaaatgc gcgcagcatt tccttggccg ccggccgctg atcgtcccga catatacgac
    16801 aggcacacat ttgtctgtgg tggcatgatg gcaatttttc agcttctggc catacgggca
    16861 ccccgcatgg ccaaagtccg ttttatcgcc atagagatgg cggaatgctt ccggggtgaa
    16921 acggaccgac gaagacgagt cgacgggagc gctgaatatg ccatgaatgg accacgacga
    16981 ctgatgacaa tagtgctggc catggtgatt ggcagcgccg tgcattccgt gccggcactc
    17041 gccgcgcgat cggccgccgg gatcatcgcg gtgcgcgccg cgatagagat gatcggcgtc
    17101 ccgtacacat ggggcggcgg cggggtgcac ggccccggat acgggatcgg aaaaggcgcc
    17161 ggcacctggg gattcgactg ctcgggcctc acggaatacg cctgggcaca ggcgggggtg
    17221 cggatcggca cgaccacgaa ggaacagtgg cgctcgggga tcaggatccc caaggagcag
    17281 gtggagccgg gcgacctggt cttctacgac agcgacaccg gcagccccgg cccagaacac
    17341 gtcgccatcg cgctgagcgc cacgcggatg gtgcacgccc cgtacacggg ggagttcgtc
    17401 cgggtggacc cgctcgaccg gcgtacgttc ctcggcgtca tccgccccgg cgagagcggc
    17461 ggcaagcgcc acgcgcgccg ctccggcggg ttcccctggt gagaaacggc cgcgcggccc
    17521 gggtcgtcct gcagtgatcg acccgggccg cacggcgcgg tgagctcggt ggccaccaag
    17581 cccgtgccgt ggcctcgcga atgtccacgg cccgtttttc ggttcacctc aaggcaccag
    17641 gaagacgacc ttggccgggc gggcccccgc acgggagccg ccgatcggct tcctgcctac
    17701 gccatgcgag gagccgtcag ttgttgtcgc ccacgtcttc ctggttgctc aggaggctgg
    17761 cgtcgatgtc ctgcaggtgc aggaacgtca gcaggtcgac gtacttcacg gagtcgttga
    17821 ggacgtcgtt gagcgccgtc aggtcgtcga gcgcactcac ctggctcagg acgctctgcc
    17881 cgttgttgtg cgggttgggg ccgatgctgg ctgatgctcc ggtggcggag aagccgaggg
    17941 ccgcggccgc gatcgcggca ccggccagaa tgcgacggat catgtttgct ttcctccatg
    18001 gatcggcgcg gaaaattcag cgcctagtcg tttgtgcagg gctgtgaggt gccggaaata
    18061 accatcgcgg caggcggacg gaaccgcaac tcagaaatcc ctcgggcagg tcaaggagac
    18121 acctcggttt cttggcacgg ggttttaccg cgcgtcaccg atctgccgct caggcaccgg
    18181 tcgggctggc ctggaaacga gaattgtttt ggtcggcggc gcgtacgatg ggcggcccgt
    18241 gcaccgcctt ttaagaaacg atcaaccgaa acttgagaat cgttcctacg ccttacgtgg
    18301 tacctggagc accttctccg gggtgacgcc gggggccgcc taaacgacga ggatgaccgt
    18361 cgagtcggcc aatccgcagg tgaggtgaga tcgatgcggc cgcgtatccg caagacggtg
    18421 atggttatcc acgtcatcac gtccgtcgcg ctgctcggag aggtgtgggg actcgtcgtg
    18481 ctgaataccg cggcggtcct gacaaaggac acggacctgg cccacgcggc ctaccggttg
    18541 atgcccaacc tgatcttcgc gggcggcata ccgctcagcc tcaccgcatt ggccacgggc
    18601 atcgcactgg gcctgaccag ccattggggg ctgttccggc attactgggt gaccgtcaag
    18661 ctcgggctgc tggtggccgt gatctgcgtc ggcatcttcc tgttcgaccc cgagggaatg
    18721 gccgccgcca cggcgggcga cgccccggtc ccgggcgccc gcgggtgggg gcagatcacc
    18781 gcgctcggca cgcagatcgc catgctggtg accgcgacca cgctgtccgt cttcaagccc
    18841 cgccgcaaac tccgatgacg gcaggacggg ccgcacgcta caaaaaacca tgagctccac
    18901 cacgccaccc ctcgtcaccg ccgccctcga ccgcgccggg gacttcgccc actcctgcga
    18961 ccccgcagtc ggccgcctcc tcgccgccct ggccgcccac gtcccccagg acgggcgcgt
    19021 gctggagctc ggcaccgggg tgggggtggg tctcgcgtgg ctggcgagcg gcctcctccc
    19081 gcgtacggac gcgaccgtga cgacggtgga gagcgacgcc gagcgagccg cgcgcaccgc
    19141 caccggcgac tggccgccct tcgtgcgcct cctcaccggg gacgcgcttg agctgctgcc
    19201 cgggctgggc accttcgacc tggtcttcgc ggacgcggtg gcgggcaagc aggtgggcct
    19261 cgacctgacg atcgccgccc tgaacccccg cggcatgctg gtcgtggacg acatgctgcc
    19321 cgctcccggc gccgtctggg acgacgagtt cgccgcccgc caggacgcgg tgcgccgccg
    19381 cctcctcacc cacgagcggc tggtggcggt ggagctgccc cacggcgtcg tcctcgccac
    19441 cgcccgctga aagccctgcc ctcgagccct cctgcgggga ccggcgccag gtccgggagc
    19501 cgtgccgccg tggtcacaac atgtggtcgt tcggcaatcg tgggaggata cttcccatgg
    19561 cagagatcgt cggcggggga cgtccggtca acgacgccga acggcgcgtg atcgcctacc
    19621 ttcgcgacca cgcgcccgcc gactggctgc tgctgcacaa cgtcgaggtc ccgcgcggcc
    19681 acgacgtctt cgaggtcgac ctcatcgtgc tgaccggcca ctcgctcgtg gtcgtcgacg
    19741 tcaagggcac caggggccgc atcgaggtgt cgggcacccg ctggttcccg ccgcgcaggg
    19801 aggcgttcgg ctcccccgtg gccaagctgc gcggcaccgc caaggcgctg aagggcctgc
    19861 tggtgtccaa ggccacccag ctggaccggg tctacgtcga cagcctggtc gtgctcacct
    19921 cgcccgacgc cgagctggtc gacccggccg ggcgcgacgc ggtcaacgtc accgacctgc
    19981 cggggctgct gcggaccctg agcgacgtct cccgggtcag gcgcgggtgc agccccgacg
    20041 cgaagccgta cctcaccgcg atcctcgacg cgctcaacca gaccgtgcgc cgcagcaccg
    20101 cgccgcccag gttcggcaac tgggaggtcg aggagcagct cggcggcgac gccaaggtca
    20161 ccgaataccg cgcgatcaac gtgacgctgc cgggcagcga gaccgtgctg ctgcgggtct
    20221 accaggccga cccgatggcc gaccacgatg cgcgggcggc cgagcggcag cgcatcgcca
    20281 acgcgtacca gacgctggcc aggatcccgc cgcacccgtg cgtggtgcgc tcgcgcgact
    20341 tcttcgccat cgacgatgag agccggttcg tgctggtgct ggacgacgtg cacggcgagg
    20401 cgctgcacct gtcgctgggc aggggcgcgg ggctgagcgt ggtccaggac ctgctgcgcg
    20461 ggctcgccca cgcccacgcc cacggcgtcg tgcaccgggc gctgaccccg gcctccgtgc
    20521 tcgtcacgga cgacgggcac gcggtgctga ccgggttcga ctacgccaag ccggggccgc
    20581 gcaactacac cgtcgcccac gagctgggca acgtgctcga cgctcactac gtggcgccgg
    20641 agtgccagga gcggcccgac cggatgacga ccgcctccga cgtctacgcg gccggcgcca
    20701 tcgcccacca cgtgctcacc ggccggctcc cgacgagccc cgacgcccag gaccccgagg
    20761 tgccggaggt ggtgcgcagg atgctcgacc acaccccggc caagcgcccg accgccgccg
    20821 aggcgctcga ggccctggag accgcgccgg tgccggagtc gcgcctcagg cggctggtgc
    20881 gtcgtctagt ctcccgatca tgacggcaat cctgcgtccg gtggcggagg acgacctccc
    20941 cttcatgcac cggctcacca gtgaccccga cgcctcgggc gagttccagt ggtacggctt
    21001 ccagaacccg caccgcctgc gcgaacgctg gacggacaac ggcatgctga gcgacgacgg
    21061 cggcgctctg atcatcgcca acggcgacga cagggtcggc ttcgtgcagt ggaccaagca
    21121 ggtcgccaac cgcgccagcc actactgggc gatggggctg atcgtggcgc ccgagcaccg
    21181 cggccagggt cacggcaccc aggcgcagcg gctgctggcg cgctacctct tcgaccacac
    21241 cacggcccac aggatcgagg cgtccaccga ggtcaccaac gtcgccgagc agcgggcgct
    21301 ggagaaggcg gggttcaccc gcgagggcgt catccgcggc agcggcttcc gcgccgggga
    21361 gtggcgcgac ggggtgcgct acagcatgat ccgcaccgac ctctgaccga tcccccggcc
    21421 atccggccga tccccggccg atctccgccc gagccggccg gccgccgccc acctgtgtgt
    21481 gagcggtcgg cgcctcacac gtgcgtgaac gtgtccagca cgtctatcac gtacagtgac
    21541 tgccggtcgc cgaggcagga gacggcgacc ctgctgccga cccgccggcc cacgagcgcg
    21601 cccagccagc cgtccggcac ggcccccttc gccagcgtga acgcgctggg cccgcccctc
    21661 cggtaggagg agtcgacgac cgcccgcgac ggccaggccg cctccacgta ctggatgacc
    21721 accttcgccc cggcggcgat ctcctcgccc gagccgtcga tgagggtgcg cggcggcgag
    21781 cccggcacga agtcggccgg gatcaccggc agcgtgcggc ccacgagccg ggcgtcgggc
    21841 gggtagccgc ccaggatgtc gaagaccagc accagcgtgt cgccgggcgc caggccggtc
    21901 atcggcacgt tcggcccgag cgcctcggcg gccgggctga ccagcatgac ccggctgccc
    21961 gccggccggc cgatgagcga gcgccgccag gtgtccgaga cctgcctgcc gtcgaagacg
    22021 accgaggtgg gctggttgcc gtcgtacgtg ctcatgtacg gccggttgcc cgaccaccgc
    22081 cggatgtcca cgtcggcgag caccacgtcg cccggcaggg tgcgccggcc gctgcccatg
    22141 gacagcacgg tgatccgcgg cgtgcggccc ggcttgccct tgggtatggc gacgaccggc
    22201 ttggtgccga acgcgcccgt gacgacgggc tgcgtgccgt cctcggccac gccgcacgag
    22261 gtggcgagca cgagcatgaa cggccagaac agacgcacga tttcctccag tgatactccg
    22321 gcgggactcc gccggcggga ctcccccggc agagtcctcg ggccgggtgc tcgggcagag
    22381 ctcctcgggc cgggctcctc aagccgggtt cctcaagccg ggttcctcag gcaggttcct
    22441 caggcagggc cgaagtccgg aagtgttact tgccgcaacc gcgaaaagga aagctgcgtg
    22501 actcgccatc tcacgacaaa ggcgcgggag gatggggggc atgagcgagc gcgacggcat
    22561 ccccgcgaga ccggcggagg gcctgtgagc aaaccgaacc tggcgcgcag ggtcgccgag
    22621 gcggcggaga tcgcgctgac cacgcggaaa tacgtgacgt tcatcgacgt ggtgacgggg
    22681 ctgcgctggc tgcactcccg gcacgtggac acctggcggc agggccgggc cgccacgctg
    22741 gccgagctgg ccgccgtcga cgaggaccgc ctgctcgcca cggccgccct gctgaaggag
    22801 tgggcgctgg cgaaggggct caggccggtg gacacgccgt acgtggcggg cacgcgcgac
    22861 cggcgcgagc tgcgcttcac cgccgcgcac gggcaggagc cgttccgcgt gcactggctc
    22921 tcgcccgacc tcagcgaggc cagggtgcgc aggctcaccg aggccaaggt gcccgatctg
    22981 gtggcggtgg ccccgctcga cgcctggacg tgcgcctcct gcggcgacac cggcccgtac
    23041 ctgatcgtgg aggacgacag cccccactgc ctgacctgcg cggacctcga ccacctggtg
    23101 ttcctgccgt cggggaacgc ggcgctcagc cgccgggcca agcaggagag cggcctgtcg
    23161 gcggtggtcg tgcggttcaa ccggcggcgc aaggtctacc agcgcgtcgg gctgctggtc
    23221 gaggagggcg cgctggccgc cgccgaggag cggtgcctgg ccgacgagga ggtccggctg
    23281 cgccggcgcg agcgcgaccg ggagcgcagg gcggagcagg acgtcgagtt ccaggccagg
    23341 atggcggccg agatcgcccg gctgttcccc ggctgcccgg cggagcgggc cacggagatc
    23401 gccgagcacg ccgcccagcg cggcagcggc cgggtgggca ggtcggcggc gggccgggcg
    23461 ctcgacgagg gcgccatcac gctggcggtc atcgcctcga tccggcatct cgacaccgac
    23521 tacgatcgcc tgctcatgtc cggcgtgccc cgcatggagg cccgcgacct ggtcagggag
    23581 cgcatcgagg gcaagctgga ggagttccgc cgatgagcga ctggcacgac gtacgcgaga
    23641 ggctgcgggc gtacgcgctc ggcctgcccg agacccacga ggaccacccg tggggcgaga
    23701 cggtgatcaa ggtcaacaag aaggtcttcc tcttcctcgg cctggacgag cagaccgaga
    23761 agtgggatcc gacgttcggc gtgaagctgg tgtcggaggc gcacggccac gcgctgaccg
    23821 tcgagggtgc ggcgccgagc agccatgggc tgggcagggc gggctgggtg accgtgccgt
    23881 tcctgtcgga gctgccggag accgacgtgc tgctcgactg ggtggaggag agctaccggg
    23941 ccgtcgcgcc caggcgggcg gtcaaggagc tcgacgagcg cccgccgggc ctcaggtgac
    24001 cgcgaggcgg gtggcgtacc tctcgtcctt ccagagctcc ttgtcgagca cgtcgagcag
    24061 cgtggcggcc gcgtcgtgga cgtcggcgta gcggatgtag agcggcgcga agccgaacct
    24121 gaggatgtcc ggcgcgcgga agtcgccgtg caccccacga tcgatcagcg cccgcatcac
    24181 cgggtagccg tcggggtggc gcaggctcac ctggctgccc ctggcggcgg ggtcggcggg
    24241 tgagaccagt tccagcgcgt caccgaccag gtcgacgaag agcgaggtca gcgccatgct
    24301 cttggcccgc acctggtcca tcggcacccg ctcccacacg tcgagcgccg cctccagcgc
    24361 cgcgaacgac agcacgtgcg gcgtgctcac cgcgaaccgc ctgatgccct cggccggccg
    24421 gaagccggct tcgaacgcga acggctcggc gtgggcgtgc cagccggaca gcacgttctg
    24481 ggcgtcggcg tggtggcgcg ggttcacgta gaggaacgcg ggcgcgccgg gacccgcgtt
    24541 gaggtacttg tacgtgcatc cgaccgcgaa gtccgcctcg gagacgtcca cctccatggc
    24601 ccccacgctg tggcagacgt cccagatcat gagggcgccg gcctcgtggg ccctcgcggt
    24661 gaccgacggc acgtcgtggc gcgcgccggt gcgatagtcg acctccgaca gcagcaccac
    24721 ggccgcgtcg tcgaagcgcc cctcggcgag gtcgcgcacc tcgtagccgc cgagcagccc
    24781 ggccaggccc tggaccatgt agtggtcggt ggggaagttg cggacgtcgg agacgatcac
    24841 ccggcgctcg gggcgcagcc gcagcgccgc cgcgaccgcc tggaagatcg cgatcgaggt
    24901 ggtgttgccg accacgacct gcccggggcc cgcgccgatc agcggggcca gccggtcgcc
    24961 ggtggtcagc ggctgggtgt accagccgga gtggttccag ccgccgacga gctgcccgcc
    25021 ccattcgtcc tcgacggcct gccgcacccg ctcgggcgtg cggcggggca gcgcgccgag
    25081 cgagttgccg acgagataga cgaccccttc tggcaacacg aactcgtccc tgaaggcccg
    25141 cagcgggtcg gcggcgtcaa gggcgaggca ctgctcccgg tccactgttt ctcctgtcgt
    25201 acggttacgc cgtcccattc tgtccggtca gccggagaac gtcgcgcgga cggtgcccag
    25261 gccgtcgatg cgcgcctcga acacgtcgcc ggcctcgacg ggcacgaccg gcccgagcgc
    25321 gccggtgagc accacgtccc cggcgcgcag cgcgtagtcg gtgcggccca ggcgggaggc
    25381 gagccagacg gcggcgttga gcgggtggcc gaggcacgcc tcgccggagc cggtcgagac
    25441 ctcctggccg ttccgcgtca tcgtcatccc ggcggcccgc aggtccagcc cgaggagcga
    25501 gacgggcgtg ccgcccagca cgaacgcgcc ggcggaggcg ttgtcggcga cggtgtcggc
    25561 cagcgtgatg tcccagtcgg cgatccgcga gtcggcgatc tcgatcgcgg gcagcgcgaa
    25621 ctccaccgcc cgcagcacgt cggccaccgt gaacggcccg cc
//
