LOCUS       NZ_CP045572            24622 bp    DNA     circular CON 07-NOV-2024
DEFINITION  Nonomuraea phyllanthi strain WYY166 chromosome, complete genome.
ACCESSION   NZ_CP045572
VERSION     NZ_CP045572.1
KEYWORDS    RefSeq.
SOURCE      Nonomuraea phyllanthi
  ORGANISM  Nonomuraea phyllanthi
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Streptosporangiales; Streptosporangiaceae; Nonomuraea.
REFERENCE   1  (bases 1 to 11273186)
  AUTHORS   Ou,Y. and Wu,Y.
  TITLE     Nonomuraea nitratireducens sp. nov., a new actinobacterium isolated
            from Suaeda australis Moq. rhizosphere
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 11273186)
  AUTHORS   Ou,Y. and Wu,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (15-OCT-2019) School of Life Sciences and Biotechnology,
            Shanghai Jiao Tong University, Dongchuan, Shanghai 200240, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. Aug-2018
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 160.0x
            Sequencing Technology             :: PacBio RSII; Illumina NextSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_009497075.1-RS_2024_11_06
            Annotation Date                   :: 11/06/2024 06:36:57
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 10,403
            CDSs (total)                      :: 10,325
            Genes (coding)                    :: 10,209
            CDSs (with protein)               :: 10,209
            Genes (RNA)                       :: 78
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 60
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 116
            CDSs (without protein)            :: 116
            Pseudo Genes (ambiguous residues) :: 0 of 116
            Pseudo Genes (frameshifted)       :: 22 of 116
            Pseudo Genes (incomplete)         :: 104 of 116
            Pseudo Genes (internal stop)      :: 8 of 116
            Pseudo Genes (multiple problems)  :: 13 of 116
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 17:05:15
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 8852946
            Orig. end                         :: 8877568
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP045572.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..24622
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="25"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..24622
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24622
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:14622](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..14622
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            complement(87..383)
                     /locus_tag="GBF35_RS40650"
                     /old_locus_tag="GBF35_40600"
     CDS             complement(87..383)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="GBF35_RS40650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GBF35_40600"
                     /product="hypothetical protein"
                     /protein_id="WP_139635461.1"
                     /transl_table=11
                     /translation="MNALWLATGDHRRLFHDKDTGMSPHSGRPTPETLAWHNTSSEKAL
                     LSVRSALIFTIATVIGVAVGALGLWAGFSVPELIIAACAAFGSAVAFLNAIIG"
     misc_feature    complement(380..393)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.97"
                     /tool="antismash"
     misc_feature    425..440
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.0"
                     /tool="antismash"
     misc_feature    complement(515..531)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 16.46"
                     /tool="antismash"
     misc_feature    complement(592..607)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: strong, score: 19.26"
                     /tool="antismash"
     gene            complement(704..1570)
                     /locus_tag="GBF35_RS40655"
                     /old_locus_tag="GBF35_40605"
     CDS             complement(704..1570)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012888245.1"
                     /locus_tag="GBF35_RS40655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBF35_40605"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_153264587.1"
                     /transl_table=11
                     /translation="MLNLIHLKVLAAVARHGSVTEAAKELHYSQSSVSHHLARLEADTG
                     AKLIQRVGRGIRLTAEGRLLAVRAAEIVGRVDAAANELAAQVGLEAGRVRLAANASALS
                     TIVPKAAVALDQAHPGLELILIDSHPVESLQMLRHGEIDLALIFQHADAPLEEEEGFRL
                     VPLCDDRIYLVSRRPGDSIADHRHSAWIGGCLRCRNELVNVCGKEGFTPRIASLSDDIV
                     VVQALVAAGRGVTTLPGLALQAHRHPGVHATELTGFSRQIHAVTYGDPPDPPAIAAVLK
                     ALAEATR"
     misc_feature    complement(1573..1587)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.84"
                     /tool="antismash"
     misc_feature    complement(1590..1604)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 18.83"
                     /tool="antismash"
     misc_feature    complement(1592..1608)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.92"
                     /tool="antismash"
     misc_feature    complement(1595..1610)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.6"
                     /tool="antismash"
     gene            1677..2324
                     /locus_tag="GBF35_RS40660"
                     /old_locus_tag="GBF35_40610"
     CDS             1677..2324
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017546800.1"
                     /locus_tag="GBF35_RS40660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBF35_40610"
                     /product="dihydrofolate reductase family protein"
                     /protein_id="WP_139635459.1"
                     /transl_table=11
                     /translation="MSDVRVHNFSISLDGFATGAGQSADAPFGHAGERLHEWMFTTRFW
                     HEMGGGREGGTGADHAFAAMHSAGIGAEIMGAGKFGPPGWQDDPDYKGAWGPNPPFHTP
                     VFVLTHRPRPSIEMEGGTTYHFLDASPAEALKKAREAADGKDVRLGGGATMIRDFVAEG
                     LVDHMHLVQVPIVLGRGVRIWDGLEAIEDVYDIEAVSTPSGVTHLTFTAKRR"
     gene            complement(2373..4628)
                     /locus_tag="GBF35_RS40665"
                     /old_locus_tag="GBF35_40615"
     CDS             complement(2373..4628)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF013124.5"
                     /locus_tag="GBF35_RS40665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBF35_40615"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_153264588.1"
                     /transl_table=11
                     /translation="MVSSFGPLLRSLRQAAHLTIEELSHASGVSVRAIGSMERGASRGP
                     QQRTVQALAEALRLSDEQRAELVEAARAGRPRPRGPVPGACELPREAGDFTGRARELET
                     LRLLAEQAGPREAAVVASISGTAGIGKTALAVHTARQLAEEFPDGCFYVDLRGMDSAPL
                     TVATALLRLLKALGVTERRVPSDEEERAGLYRALLADRRCLIVLDNAADEAQVRPLLPA
                     SGAVMTIVTSRRSLSGLEGARQIPLGQLTDQEAAGLLQAIVGGKRTEADPDGVARLARL
                     CGNLPLAVRIAGNRLLSRPGWTVSQLAGRLGDEERRLESLAAGDLAVAAAFALSYRQVS
                     GTARVAFRRLALAAAPDFGVPLAAVLTGADLYEAEDALEELVELGLLTSPYAGRYVFHD
                     LVRLYARTQLEQEEPVAVRQEARVRMESWLLDVAGVAGRWFKDGAPPPEWRSTVTLDSR
                     QEASDWLQTEGTAWLEALRSAARRGEHSTVVEVVGSLDWFADLWRPWGHWREVFELSSG
                     SARAMGDRLQEAVHLNWLSWALTVERRHEEAEATALRGLEAAREVGDVRQQGWALAYAS
                     EALPRASTETLERDLDYSRRAAELFLQAGDAEGYPQAMMRHMSALRRAGRFEDAVEHGL
                     SVVATMRDPAYGGSSAMVSYGLGAVLSQLAHACLALERWEDAVEFFHQALSELSAHPIL
                     QVVGRAQRGLGGALRQLGRIEEARKALTEAARLLEECGLTEEAAKVAEELGDLPDPA"
     gene            complement(4768..5346)
                     /locus_tag="GBF35_RS40670"
                     /old_locus_tag="GBF35_40620"
     CDS             complement(4768..5346)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017586777.1"
                     /locus_tag="GBF35_RS40670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBF35_40620"
                     /product="dihydrofolate reductase family protein"
                     /protein_id="WP_139635457.1"
                     /transl_table=11
                     /translation="MTATYTFDVFSSLDGFGAAGGNWTGYWGKQGPELLDHRLALYSEE
                     QRMVFGATTYRAFAEMLASSTEESEVRDPWVTRMTNLPATVVSTTLQGPLDWPDATVVS
                     GDAVEVVARLKEESEVPLRSHGSLAMNRALMAAGLVDRVQVTLFPVITGQTGADPIFQG
                     AADFDLELIEHRTLDGHIQELVYRPALHV"
     gene            5602..6708
                     /locus_tag="GBF35_RS40675"
                     /old_locus_tag="GBF35_40625"
     CDS             5602..6708
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1251: luciferase
                     family protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF012517.5"
                     /locus_tag="GBF35_RS40675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBF35_40625"
                     /product="LLM class flavin-dependent oxidoreductase"
                     /protein_id="WP_153264589.1"
                     /transl_table=11
                     /translation="MSVTAINTATTRTQPSPFEIGFMTFVEITEDPRTGALPSAHQRAR
                     ETIEQARLADQVGLDLFAVGEHHRTDFVGSAPPMVLAAAAEATERIRLTSSVTVLSSED
                     PVRVWEQFATLDQFSGGRAEIIAGRGSYTESFPLFGHDLADYADLFREKLDLLLEIRAR
                     NPITWKGRFRPALDNADIGPRALQDELPIWVGVGGTLASAISTGRLGLPMAMALLLGPI
                     TYHEQTVEMYRAAAERAGHDPAALRTSINLHGYVSRTSRRARDTMYPYFARGMMDNNHQ
                     RGKGFTMPRTAFDAQTSPNAGLVVGSPQEVIDKLLAYHEIYGLDRALIQMGFGGMPQKD
                     VLDAIELLGTEVAPVVRREVAARKARTA"
     gene            6705..7361
                     /locus_tag="GBF35_RS40680"
                     /old_locus_tag="GBF35_40630"
     CDS             6705..7361
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015325.5"
                     /locus_tag="GBF35_RS40680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBF35_40630"
                     /product="NAD(P)H-dependent oxidoreductase"
                     /protein_id="WP_153264590.1"
                     /transl_table=11
                     /translation="MTAPPSAPTAPSASVHAAGVDGAGDAPGRTLRVVVVNGSPSEKSK
                     TMGLVDVVLQELSAKLAPEGVAVDQTRIDVYRLGPAFTGAVEREHIAPEVEAALRQAEQ
                     ADLLIAATPVFRGSYTGLFKHFFDLIDQYALANKLVLLAATGGGDHHALVLEHALRPLF
                     GFFQAMTVPVAVFASSGDFDGTTLLNPRVYGRVEMAITDVLDLLKARSAPSPIRR"
     gene            complement(7477..8184)
                     /locus_tag="GBF35_RS40685"
                     /old_locus_tag="GBF35_40635"
     CDS             complement(7477..8184)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1170: metallo-beta-lactamase family protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012955.5"
                     /locus_tag="GBF35_RS40685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBF35_40635"
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="WP_153264591.1"
                     /transl_table=11
                     /translation="MKLAPHLHRLGNDLVACYLVDTAEGITLIDAGLPGHWRDLQHELR
                     ALGKSVDDIRGLVLTHGDFDHIGFAERLRRAHGVPVFVHAADAVRARTGEKPKVAVGPM
                     RLGPTLGFFGYSIRKNGLRPRYVGEVTEIGDGDVLDLPGSPVIVGMPGHSPGSVAVHVP
                     VADAVFVGDALTTRHVLTGREGPQPAPFTDDPDEALSSLDRIAGLSASWVLPGHGAPWR
                     TSPAQVGEAVRKG"
     misc_feature    complement(8221..8234)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.55"
                     /tool="antismash"
     gene            8278..8808
                     /locus_tag="GBF35_RS40690"
                     /old_locus_tag="GBF35_40640"
     CDS             8278..8808
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1239: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF024701.5"
                     /locus_tag="GBF35_RS40690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBF35_40640"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_139635452.1"
                     /transl_table=11
                     /translation="MPTPEKTSLRRIVAAGRDLLEAHGQQGLTMQNVAERVGVRAPSLY
                     KHVGSRAALLAAVAEATIDDLIALLESTDGSLEGLARGYRRFAHAWPQGFRLMLSPDAP
                     PEALARVAVPVLDASRRLVGERDALEAARLVTAWANGFIEMELIGAFRLGGDVDHAFEY
                     GLAGIRRALATAP"
     gene            9115..9864
                     /locus_tag="GBF35_RS40695"
                     /old_locus_tag="GBF35_40645"
     CDS             9115..9864
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF015649.5"
                     /locus_tag="GBF35_RS40695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBF35_40645"
                     /product="AfsR/SARP family transcriptional regulator"
                     /protein_id="WP_193318874.1"
                     /transl_table=11
                     /translation="MLGTLAIWWEEGCIEIAAAKHRTVLAILLANPNRTVNVGMLIDEL
                     WPGLAPSTARKTVQGYVWRLRRALGPFADRLVTTGSGYRMVLPADGTDVLEFERSVDTA
                     RVALHAGASERAVGELTRALDLWRGPAFDCVPRSPAIEAYAVRLDEAYVAAQESLIATR
                     LSLGRPAEVVPDLVGLAAAHPHRESLHRHLMTALHRTGRRLDALDVFRRLRFRLAADYG
                     LEPDRQTVELHQALLQDRVDVAGFPQR"
     gene            10001..11350
                     /locus_tag="GBF35_RS40700"
                     /old_locus_tag="GBF35_40650"
     CDS             10001..11350
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.5"
                     /locus_tag="GBF35_RS40700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBF35_40650"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_193318873.1"
                     /sec_met_domain="LANC_like (E-value: 4.1e-41, bitscore:
                     140.1, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATAIMHRLSDETLVTEVAKDASRTMGLPVWEPGASLYAGAAGSA
                     LAFAYAARACPDSSEHWWAQAHRWLKLAAAGTRDKPLVVPGLSDGTAGMALAVAGCDPD
                     GRYARTLSGLHTRLSEQVGRPDLADDHDFFYPDYDVMTGPAGILGQLAPHLADPTALRV
                     ASGIVERLIARCDTAGPREHESGSLRTAPWKPWFIARKHYDRWKEEVRLNPYGFVNLGL
                     AHGIPGPLAALSRAWLAGHRAPGLREAIRALGDQLVAASRHEDWGRTWPRVLPFDEAGE
                     VAPDRGRPTRPSYCYGAPGIASALLDAADALGDDTMRTVAVEGFEAALRQMEDLPAAAL
                     NYPGLCHGDAGMVLICRKFATQTGSAAARSALERLVDRLLGHCDPDRPLLVRDYRPVQA
                     AEPGSPSALDPDGTWVDNPGLLEGAAGVALTLLSVATPVPPFWARAVLVN"
     gene            11380..14622
                     /locus_tag="GBF35_RS40705"
                     /old_locus_tag="GBF35_40655"
     CDS             11380..14622
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.5"
                     /locus_tag="GBF35_RS40705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBF35_40655"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_153264592.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 9.1e-154,
                     bitscore: 512.3, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 1e-10,
                     bitscore: 41.4, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 2.2e-27, bitscore:
                     95.7, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQPGSGPVATARAYGTGLYAASDLFVLRAPVLPADTFVNLGANA
                     AVPAPAGTAETLAAARAEGRGTLRTLAASPRVRQAIQVASPSLAAALPRLDENVPRDRA
                     ADRAYAALLRYLIRMSTRPTPLGLFAGVAPGAFLSEPAAGGEGIATLDRDPVRATRTRA
                     DSAWLANLVERIGRDPKVRDKLRVRVNALLRRAGDRAVLVKADGMDEPERIELAVNPAF
                     AAVLDLAGHEPAYGELAAALAHRFPSTSPEKIRALLDRLWDLGVLLPDLLPSPTEPLPE
                     VHLAKRLIDQDAPTGVIDGLTRLRQLADGVDRGHGDVAGLARLEAHQRAMAPDFTGPAF
                     QIDTALALEPATLPADVAAAAAEAADLLMRLGCVQQRRPHIAGYHEVFLEHYGIDAEVP
                     LLDVLSPETGLGPPGSYTRPAGRHPWPRQAGQTHPERDRTLVELALHAAREGRPTVDLD
                     DELIDRLTVWRPDAEHSRPRTSLDLFFALAADSPEAIRDGRWRMVLNTIGVFGGWQAFG
                     RFFDLFDEAAVTRIRAQQRLEEALRPDTIFAELNYGVRHRGGNVAGHPPTRDHEVCVNA
                     AATGPPVRQIPLTDIVLCADADHFHLRSVSLGRTLSVGQTHALTATRAPNICRALLEFS
                     EDGYTPPCRFDWGAAADAPFLPRLTRGNVVVQPAQWTITAATFPACQDPDDFFRACRTW
                     RRQWMVPRYVYLVELDNRLLLDLEHPTWVDWLHRHVTRLPARSGESVRLHEALPGPGDL
                     WLRDRAGRPYHAELAVPLVLRDRTRMPEPAAARTAAPPTTTRRWLAGDEWTHLKLYAAA
                     ELHDAIITGPLRELLADDRFGRLVDRWFFIRYADPLPHLRLRFHARGPEPAAEVMSRCA
                     TWARGLVHAGQATDLVFCSYDREVERYGGGHAIDSVETAFWANSQAAVELLRLLRTGRF
                     DPDLVRVAALHELYQAWGAGPPPLDGDGVATWMTDAARKRFRDVRPLLCEILTPGERRP
                     DHRAPEYRAALEPVFARQRRPLAEAGRWVRDLASRGLLTGGERDIIESLAHMQSIRLAG
                     IDRDQERLSWALWSLSRRAIRSRPAATAGAPR"
     aSDomain        11935..12198
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_GBF35_RS40705_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="2.80E-13"
                     /identifier="RREFam001.1"
                     /label="GBF35_RS40705"
                     /locus_tag="GBF35_RS40705"
                     /protein_end="273"
                     /protein_start="185"
                     /score="41.4"
                     /tool="antismash"
                     /translation="RVRVNALLRRAGDRAVLVKADGMDEPERIELAVNPAFAAVLDLAG
                     HEPAYGELAAALAHRFPSTSPEKIRALLDRLWDLGVLLPDLLP"
     gene            14804..16705
                     /locus_tag="GBF35_RS40710"
                     /old_locus_tag="GBF35_40660"
     CDS             14804..16705
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF013124.5"
                     /locus_tag="GBF35_RS40710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBF35_40660"
                     /product="AfsR/SARP family transcriptional regulator"
                     /protein_id="WP_194244000.1"
                     /transl_table=11
                     /translation="MTVGVLGPLYVAVEGRPIRLTAGKPRALLAALAMSAGRVVSVERL
                     AEMVWCDRFPANSRRSLQNYAARLRSAMGDRLIETCPGGLLLRADAGDIDALRFLRTLD
                     RAARAQDSDAERGLLDEALALWRSEPFEDVDSPWLRESEAPHLIERHLAALERRVDLDL
                     VGGRKSRFTADLRRLTSRHPLRESLWLRLLRALVQDGRRAEVLDRYEELRARLAHELGV
                     DPDPAIQRLYAEQLADHPKAYAEPRADHPHAPAVAGLSATGGPPDRPTEVASLFATSPR
                     RLPTATADFVGRERDLASLAALVRAEPATAIVVDGMAGVGKTTLVVHNAHQVAARFPDG
                     QLFIDLHGHTPGCAPVPPEDALHRLLRTLGVPADRIPPHLEDRAALYRDLLADRKVLLV
                     LDDAVGEAQIRPLLPGSASCRVLVTSRRRLTGLDGTRALTLGVPSPADAIAMFTRVAGP
                     HRVAGTAAGTLAETVTRCELLPLAIRLAATRLRSHPTWSVVRLLARLTPARRRLAELAV
                     GERSVAVAIDMSYRSLPDRLQRAYRLLCGYGFESFSADQAAALMGTDTMAAERLLEGLM
                     DVNLLQEPAPGRYAFHGLIRDHGAELAMEEGGSPTGRAAPLLGLPCPPRGALAEHDG"
     gene            complement(16777..16917)
                     /locus_tag="GBF35_RS40715"
     CDS             complement(16777..16917)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="GBF35_RS40715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_153264594.1"
                     /transl_table=11
                     /translation="MKFFARFLAATAVAGLALVGASYASAANASTGVQASGIFDNDCCN
                     N"
     misc_feature    complement(16945..16959)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.4"
                     /tool="antismash"
     gene            complement(17159..17707)
                     /locus_tag="GBF35_RS40720"
                     /old_locus_tag="GBF35_40665"
     CDS             complement(17159..17707)
                     /EC_number="1.11.1.24"
                     /GO_function="GO:0008379 - thioredoxin peroxidase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF020123.5"
                     /locus_tag="GBF35_RS40720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBF35_40665"
                     /product="peroxiredoxin"
                     /protein_id="WP_228011542.1"
                     /transl_table=11
                     /translation="MDGATAAAIVVVGVLGGLNLLLVLLALHRLREYTGKWARAGLDQL
                     LERHSVPRAGDRVTDFTATATDGGTVSLGGLKGPLFAAFFSAGCSSCRRALPRFVEYAK
                     ALSGGREQILAVVAGPAEQGADIVDAVREVARVVVEPQTGPVSQAFGVRNWPTFVVLDQ
                     DGTVRKSAGDLREVTPARP"
     gene            complement(17723..18259)
                     /locus_tag="GBF35_RS40725"
                     /old_locus_tag="GBF35_40670"
     CDS             complement(17723..18259)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_process="GO:0030416 - methylamine metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF018942.5"
                     /locus_tag="GBF35_RS40725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBF35_40670"
                     /product="MauE/DoxX family redox-associated membrane
                     protein"
                     /protein_id="WP_228010588.1"
                     /transl_table=11
                     /translation="MLIAYIGFGCRILLALVFVAAAASKLRGRRDFIEFRATVSAFGVK
                     PRWSSAAAGAVIACELAAAALMPVGVTAPAGLGIGAALLIVFSLVIASALRRGTSTSCR
                     CFGTSTRPLGARHLVRNAILLVIAGAGLAGTVLTGHTGSAGFDTAALIVSGFAAVVVAA
                     LVIAYDDLVALVLPR"
     gene            complement(18481..18705)
                     /locus_tag="GBF35_RS40730"
                     /old_locus_tag="GBF35_40675"
     CDS             complement(18481..18705)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="GBF35_RS40730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GBF35_40675"
                     /product="hypothetical protein"
                     /protein_id="WP_139635442.1"
                     /transl_table=11
                     /translation="MSIDTIQVADPIAFAGAHALDTRSQDPADIALMDEFDLDILVSSM
                     PGEIRAGECDRWSNCVCITVCATHPWSCA"
     misc_feature    18669..18683
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.92"
                     /tool="antismash"
     gene            complement(18981..20663)
                     /locus_tag="GBF35_RS40735"
                     /old_locus_tag="GBF35_40680"
     CDS             complement(18981..20663)
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016497.5"
                     /locus_tag="GBF35_RS40735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBF35_40680"
                     /product="family 43 glycosylhydrolase"
                     /protein_id="WP_228010589.1"
                     /transl_table=11
                     /translation="MAVLLLGVLIGAAATVPGVPAASAAPVAAAGEPSAQPSPDPIAHD
                     PTLIRQGRYYYEIITGDIETRTYLPIRRSTDLVHWTFLGTVFTMPPQWVVDELGVTPGD
                     FWAPDLSYFDGEYHLYYAASSFGTNNSVIGLATNATLDPGSPDYRWVDRGMVLRSRTSD
                     NYNAIDADVTFDEDGMPWLSFGSFWDGIKMRRLDAATGLLSTEDTTLYSLASRGGAAIE
                     GPSIVRKGRYWYLFASFDFCCRGVNSDYRIVVGRSTSLHGPYVDRDGRPLLQGGGTELL
                     RGYNGFQGTGGGDVLLRRGKGPDLYVHHYYDAADGALPKGSVRPISWDGGWPRLGDPLS
                     GNRGHGRGPAYVTLVSHDGAGSIDNSTCGYEGADIRLTATEAGDACRQWRLEYRGGGWS
                     SILNRHSNKVAEVAACVNADGARVAQWGWLDNDCQKFRFLPTDHGWSRIENKLAGRVLD
                     ACDRPDGAVQTFTWRGEACQQFRIQPVGDVLITDPADRKRLGDTWRFVHIDEGYYRIAD
                     SRTGRSLGGRGSVWRVEVTDAGTYRLVTRDGGTTREVLLLTPH"
     gene            complement(21030..21869)
                     /locus_tag="GBF35_RS40740"
                     /old_locus_tag="GBF35_40685"
     CDS             complement(21030..21869)
                     /NRPS_PKS="Domain: Abhydrolase_1 (15-126). E-value:
                     3.8e-25. Score: 80.8. Matches aSDomain:
                     nrpspksdomains_GBF35_RS40740_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012895556.1"
                     /locus_tag="GBF35_RS40740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBF35_40685"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_228010590.1"
                     /sec_met_domain="PF00561 (E-value: 1.6e-20, bitscore: 73.0,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 6e-20, bitscore:
                     72.0, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRIDGLACDEVGEGPAVVLVHAGIADRRMWRHQRDFLSDRYRVI
                     SYDWRGYGESAEPAGDLVHHEDLLRVMDGLGVERAALVGDSMGGSYAVEAALVAPDRVA
                     GLVLISSGLSGHTWPDDMMAQARERVHSTVPAERLARYRSGTAGRVLPEDLDAFARAHA
                     LWQVAGPDRRLDDLDPEVWELAFAMMRQVFERSWSRRPVPERHLSAKERLREITAPTLV
                     INGLADVPGIQAVSDLLADEIAGARRLDLPATGHLPPLERPTEVNAALSSFLGDLSW"
     aSDomain        complement(21492..21824)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_GBF35_RS40740_Abhydrolase_1.1"
                     /evalue="3.80E-25"
                     /label="GBF35_RS40740_Abhydrolase_1.1"
                     /locus_tag="GBF35_RS40740"
                     /protein_end="126"
                     /protein_start="15"
                     /score="80.8"
                     /tool="antismash"
                     /translation="PAVVLVHAGIADRRMWRHQRDFLSDRYRVISYDWRGYGESAEPAG
                     DLVHHEDLLRVMDGLGVERAALVGDSMGGSYAVEAALVAPDRVAGLVLISSGLSGHTWP
                     DDMMAQA"
     misc_feature    complement(21908..21923)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.61"
                     /tool="antismash"
     gene            21969..22316
                     /locus_tag="GBF35_RS40745"
                     /old_locus_tag="GBF35_40690"
     CDS             21969..22316
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="GBF35_RS40745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GBF35_40690"
                     /product="hypothetical protein"
                     /protein_id="WP_153264598.1"
                     /transl_table=11
                     /translation="MKEVEPLVRQVLAESGFPAIDLQREPWVVARDVAQAVAEGTLPIG
                     KGADFLILELREKWTTPEEIWELNLLIDDGKALRGAPPADGELRQQASKIAEAAPGWRD
                     APQDPDLLPPD"
     misc_feature    complement(22003..22016)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.18"
                     /tool="antismash"
     gene            22532..23320
                     /locus_tag="GBF35_RS40750"
                     /old_locus_tag="GBF35_40695"
     CDS             22532..23320
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020546616.1"
                     /locus_tag="GBF35_RS40750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBF35_40695"
                     /product="hypothetical protein"
                     /protein_id="WP_153264599.1"
                     /transl_table=11
                     /translation="MRTWLARAVVSFLMVPLTAAPAASSASAHTDARTCARANLLFCED
                     FQAMPVGGASSLRWGIDTKHGTLTVERAGRRGQKVLRVHTEGNGRAFLKVDDFAAPGNS
                     FYGRVRLRASAFPTAPDWAHYTLVEATGDGPEIVRPLGGQYAPPPHGGAAYWGVGADGG
                     PTGDWTNWQTTAPSVAGTWTCVEWHMDAGDNRISVWFDGVAKPELTVSTREHGGNPVDF
                     VFPRFDTIKLGWQLYQENPTPAGYDVWMDDIALSSRRVGC"
     misc_feature    24495..24510
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 20.87"
                     /tool="antismash"
ORIGIN
        1 gtctgacgtc tgaccggctc catcaaccgt gtgaggacgc acccggcggc gccgacggcg
       61 accgccaccg gggcggctga ggcacgtcag ccgatgatcg cgttgaggaa ggccacggcg
      121 gagccgaatg cggcgcaggc agcgatgatc agctcaggaa cggagaagcc cgcccagaga
      181 ccgagcgcgc ccacggcgac gccgatcacg gtcgctatcg tgaagatcag ggccgagcgg
      241 acggacagca gggctttctc gcttgaggtg ttgtgccagg cgagggtctc tggagtgggt
      301 cgacccgagt gtgggctcat gccggtgtcc ttgtcatgga agagtcgtcg gtgatcccct
      361 gtcgcgagcc agagggcgtt cacgtggagt gacgaaattg aacttactgc gtcgcgcccg
      421 aacctcgatc gcgtgttccc gttgtggcgg accttaggca tccgaccagc ggcttgtcgg
      481 ttagatagga atgctctaat ggtggtgatc cgccatgttt tgtcgttcca cgcatgatgg
      541 cgcgacatcg atcgtccgtc acacctcgat cacacagtgc gaccgatctg atgtgacgag
      601 ggtcacaggc agaatctgga gagctgcgac acttcggcgt ggcgtgatgc cgcggccggg
      661 agaccgatcg tggcgccggc gtcgcggacg ccttgggcgt cgttcacctg gtcgcttcgg
      721 cgagggcctt cagcacggcg gcgatggcgg gcgggtcggg cgggtcgccg taggtgacgg
      781 cgtggatctg gcgggagaag ccggtcagct cggtggcgtg gacgccgggg tggcggtggg
      841 cttggagcgc gagacccggc agggtggtga cgccccggcc ggcggcgacg agggcctgca
      901 cgaccacgat gtcgtcgctg agtgacgcga tgcgcggggt gaagccttcc ttcccgcaca
      961 cgttgaccag ctcgttccgg caccgcaggc acccgccgat ccaggcggaa tggcggtggt
     1021 cggcgatgct gtcgccgggc cgccggctga cgaggtagat ccggtcgtcg cagaggggga
     1081 cgaggcggaa cccctcctct tcctcgagcg gcgcgtccgc gtgctggaag atgagcgcga
     1141 ggtcgatctc gccgtgccgc agcatctgca gcgactcgac cgggtggctg tcgatcagga
     1201 tcagctcgag tcccgggtgc gcctggtcca gcgcgacggc cgccttgggc acgatcgtgc
     1261 tcagcgccga cgcgttggcg gccagccgga cccgccccgc ctccaggccc acctgtgccg
     1321 ccagctcgtt ggcggccgcg tcgacccgtc ccacgatctc ggcggcccgg acggccagca
     1381 gccgcccttc cgcggtcaat cggatcccgc ggccgacccg ctggatcaac ttggcgccgg
     1441 tgtccgcttc caggcgtgcc aggtggtgac tcaccgacga ttgcgagtag tgcagctctt
     1501 tcgccgcttc cgtcacggac ccgtgccgcg ccaccgcggc cagaaccttg agatgaatca
     1561 ggttcagcat tcatcgagaa tatcgatgca attgtcgaaa cattagcatt agacgccata
     1621 aatgcattgg tccatgctgg tgctcgccag gaagaacgac gccgaaggag cacctgatgt
     1681 ccgatgtacg agtgcacaac ttctccatct cgctcgacgg cttcgccacc ggcgccggcc
     1741 agtccgccga cgccccgttc ggccacgccg gcgagcgcct gcacgaatgg atgttcacca
     1801 cccggttctg gcatgagatg ggtggcggcc gggagggcgg caccggcgcc gaccacgcgt
     1861 tcgccgcgat gcacagcgcc ggcatcggcg ccgagatcat gggcgccggc aagttcggcc
     1921 cgcccggctg gcaggacgac cccgactaca agggcgcctg gggacccaac ccgccgttcc
     1981 acacgccggt cttcgtcctc acccaccggc cgcggccgtc gatcgagatg gagggcggca
     2041 cgacgtacca cttcctggac gcctcacccg ccgaggcgct caagaaggcc cgcgaggcgg
     2101 ccgatggaaa ggacgtgcgg ctcggcggcg gcgccacgat gattcgcgac ttcgtcgccg
     2161 aagggctggt cgatcacatg cacctggtcc aggtcccgat cgtgctcggc cgcggcgtcc
     2221 ggatctggga cggcctggag gcgatcgagg acgtgtacga catcgaggcg gtctcgaccc
     2281 ccagcggcgt cacgcacctg accttcaccg ccaagcgccg gtgaccgcgc agggaaggcc
     2341 actcgtacgg cggctcatca cgagcgccgc agctacgccg ggtccggcag gtctccgagc
     2401 tcctcggcca ccttggcggc ctcctcggtc aggccgcact cctccagcag ccgtgccgcc
     2461 tccgtcaacg ccttccgggc ctcctcgatc cggcccagct gccgcagcgc gccgcccagc
     2521 ccgcgttggg ctctgcccac gacctgaagg atggggtggg cgctcagctc gctcagagcc
     2581 tggtggaaga actcgaccgc gtcctcccag cgttcgagcg ccaggcaggc gtgggcgagc
     2641 tggctcagga cggccccgag gccgtagctg accatggccg aggaaccgcc gtaggcgggg
     2701 tcacgcatcg tggccaccac cgacaggccg tgctccacgg catcctcgaa gcggcccgcc
     2761 cgccgcagcg cgctcatgtg acgcatcatg gcctggggat agccctccgc gtccccggcc
     2821 tgcaggaaga gctcggcggc tcgccggctg tagtcaaggt cgcgctccag ggtctccgtg
     2881 gaggcgcgag gaagggcttc cgaggcatac gccagcgccc agccctgctg gcgtacgtcg
     2941 ccgacctcac gggcggcctc cagtccccgc agcgcggtcg cctccgcctc ctcgtgacgc
     3001 cgctccacgg tcagcgccca ggacagccag ttgaggtgca ccgcctcctg cagccggtcg
     3061 cccatggcgc gcgccgagcc ggaggacagc tcgaacacct cccgccagtg cccccacggc
     3121 ctccacaggt cggcgaacca atccagggac ccgaccacct cgaccaccgt cgagtgctct
     3181 ccacgccggg ccgccgagcg cagtgcctcc agccaggccg tgccttccgt ctgcagccag
     3241 tcgctcgcct cctgccggct gtcgagcgtg accgtcgacc gccactccgg cggcggcgca
     3301 ccgtccttga accagcgtcc ggccacccct gccacgtcca gcagccagct ctccatccgc
     3361 acgcgcgcct cctggcgcac cgcgacgggc tcctcctgct ccagctgggt gcgggcgtac
     3421 aaccggacca ggtcgtggaa gacgtaacgg ccggcgtacg gggaggtcag caggcccagc
     3481 tcgaccagtt cctccagcgc gtcctcggcc tcgtacaggt ccgccccggt caggaccgcg
     3541 gccagcggca ccccgaagtc cggcgcggcg gccagcgcca gccgccggaa ggcgacccgc
     3601 gccgtcccgg acacctgccg gtacgagagc gcgaacgcgg cggccaccgc caggtccccc
     3661 gccgccagcg actccaagcg gcgctcctca tcacccagcc ggcccgcgag ctggctcacc
     3721 gtccagcccg gccggctcag cagccggttc cccgcgatcc gcaccgccag cggcaggttc
     3781 ccgcacaacc gggccaatcg cgccacgccg tccggatcgg cctcggtccg cttcccgccc
     3841 acgatcgcct gcaacagccc ggccgcctcc tgatcggtca gctggcccag cgggatctgc
     3901 cgcgccccct ccagcccgga cagggaacgc cggctcgtga cgatcgtcat caccgccccg
     3961 gacgccggca gcagcggccg cacctgcgcc tcgtcggcgg cgttgtccag cacgatcagg
     4021 caccgccgat cggccagcag cgcccggtac agccccgcgc gctcctcctc atcgctggga
     4081 acccgccgtt cggtcacgcc cagggccttc aacagccgca gcaacgccgt cgccacggtc
     4141 agcggggcac tgtccatgcc gcgcaggtcc acgtagaagc agccgtccgg gaactcctcc
     4201 gccaactgcc gggcggtgtg cacggccagg gcagtcttgc cgatcccggc ggtgccggag
     4261 atcgaagcca ccaccgcggc ctctcgcggg ccggcctgct ccgccaggag gcgcagcgtt
     4321 tccagctctc gcgcccggcc ggtgaaatcg cccgcctcac gtggcagttc acacgcgccc
     4381 ggcaccggcc cacgcggccg cggccgtccc gccctggcgg cctccaccag ctccgcccgc
     4441 tgctcatcac tcagccgcaa cgcctcggcc agcgcctgca ccgtccgctg ctgcgggccc
     4501 cggctggcac cgcgctccat gctcccgatc gcccgcacgc tcaccccgga cgcgtgcgac
     4561 aactcctcga tcgtcaagtg cgcggcctgc cgcaaactcc gcaggagcgg gccgaacgag
     4621 ctgaccatcc gtcctcctca gcaccgccgg cgctccgggc ggattgctcc aaaatacccg
     4681 gagttccggc gatcagcggt cagcgagccc cggtccgggg cggccatgtg agaggccgga
     4741 ggaacgtcca gtcaggttcg gccgggctca gacgtgcagg gcgggccggt agacgagctc
     4801 ctggatgtgg ccgtcgagcg tccggtgctc gatcagttcg aggtcgaagt cggccgcccc
     4861 ctggaagatc gggtccgctc cggtctgccc ggtgatcacg gggaagagcg tcacctgcac
     4921 gcggtcgacc aggccggcgg ccatcagcgc ccggttcatc gccaggctgc cgtgcgagcg
     4981 aagcggcacc tcggactcct ccttgagccg ggcgacgacc tcgacggcgt cgccgctcac
     5041 gacggtcgcg tccggccagt cgaggggtcc ctgcagcgtc gtcgacacca ccgtcgccgg
     5101 caggttcgtc atccgggtga cccacgggtc acgcacctcg gactcctcgg tgctcgaggc
     5161 cagcatctcc gcgaacgccc gatacgtggt ggccccgaag accatccgct gctcctcgct
     5221 gtacagggcg aggcggtggt cgagaagctc cgggccctgc ttgccccaat agccggtcca
     5281 gttgccgccg gcggcgccga agccgtcgag gctgctgaag acgtcgaagg tgtacgtagc
     5341 ggtcatgtcg ctctcccgga gtgcccgttg gtggcgtgtc agtgatacag accaccggcc
     5401 acggcgaaac tcatcgccgc tcctcgcgtg acagccggga caggggcagg gacagggtgc
     5461 cgtgccggcc atgctcatct tcagcgggcg aggccggctc cgatccctcg ccggacgtgg
     5521 cgatgcgccc gggaatatct gtctgcgcag acatctttat acgctacgaa ccgctccacc
     5581 cgggcatcac ggaggatcat catgagtgtc accgccatca acaccgcgac caccaggacg
     5641 cagccgtccc ccttcgagat cggcttcatg acgttcgtcg agatcaccga ggacccgcgc
     5701 accggcgcgc tcccgtcagc gcaccagcgg gcgcgggaga ccatcgagca ggcccgcctc
     5761 gccgaccagg tcggcctcga cctgttcgcc gtcggggagc accaccgcac cgacttcgtc
     5821 ggctcggccc cgccgatggt cctggccgcc gccgccgagg cgaccgagag gatccgcctg
     5881 accagctcgg tcaccgtgct cagctccgag gacccggtgc gcgtgtggga gcagttcgcc
     5941 acgctcgacc agttctccgg cggccgggcc gagatcatcg ccggccgtgg ctcgtacacg
     6001 gagtcgttcc cgctgttcgg ccatgacctg gccgactacg ccgacctgtt ccgcgagaag
     6061 ctcgacctcc tgctcgagat ccgcgcccgg aaccccatca cctggaaggg gcggttccgc
     6121 ccggcgctgg acaacgccga catcggcccg cgcgcgctcc aggacgagct gccgatatgg
     6181 gtgggcgtgg gcggcaccct ggcgtccgcg atcagcaccg gacgcctcgg cctgcccatg
     6241 gccatggccc tgctgctcgg gcccatcacg taccacgagc agacggtcga gatgtaccgc
     6301 gccgccgccg agcgggccgg tcacgatcct gccgcactgc gcacgagcat caacctgcac
     6361 gggtacgtca gccgcacgag tcggcgcgca cgcgacacca tgtacccgta cttcgcccgg
     6421 ggcatgatgg acaacaacca ccagcgcggc aaggggttca cgatgccccg caccgcgttc
     6481 gacgcccaga cctccccgaa cgccggcctc gtcgtcggga gcccgcaaga ggtgatcgac
     6541 aagctgctcg cctaccacga gatctacggc ctggaccgcg ccctcatcca gatgggcttc
     6601 ggcggcatgc cgcagaagga cgtgctcgac gccatcgaac tcctcggcac cgaagtggct
     6661 cccgtggtgc ggcgcgaggt cgccgcgcgg aaggcgagga cggcatgacc gccccgccct
     6721 ctgcacccac cgcaccgtcc gcatccgtcc acgctgccgg cgtcgacggc gcgggcgacg
     6781 cgcctggccg cacgctgcgc gtggtggtcg tcaacggcag cccgagcgag aagtccaaga
     6841 ccatgggact ggtcgacgtc gtcctccagg aactgagcgc caagctcgcc cccgagggcg
     6901 tcgcggtcga ccagacccgg atcgacgtct accggctcgg ccccgcattc accggagccg
     6961 tcgagcgcga gcacatcgca cccgaggtcg aggccgcgct ccgccaggcc gagcaggccg
     7021 acctgctgat cgcggccacc ccggtgttcc gcggttcgta caccggcctg ttcaagcact
     7081 tcttcgacct gatcgaccag tacgcgctcg cgaacaagct ggtcctgctg gccgccaccg
     7141 gcggcggcga ccaccacgcc ctcgtcctgg aacacgcgct gcggccgctg ttcgggttct
     7201 tccaggcgat gaccgtcccg gtggccgtct tcgcctcgtc gggcgacttc gacggcacca
     7261 ccctgctcaa cccccgcgtc tacggacgcg tcgagatggc gatcaccgac gtgctcgacc
     7321 tgctcaaggc gcgctcggcc ccctcaccga tcaggaggtg acgccgtacg gcgacgggca
     7381 ggtccgtacg caggtgcagg gagccatcgt tcggccgaca gctcgcggac ctggacgcgc
     7441 ttcctgccag ggacgcccgg cctggatcgg ggcggatcag cccttcctga ccgcctcgcc
     7501 cacctgggcc ggtgaagtgc gccagggggc gccgtggccg gggagcaccc aggacgccga
     7561 caggccggcg atccggtcga gagaggagag cgcttcgtcc ggatcgtcgg tgaagggcgc
     7621 gggctgcggg ccttcgcgcc cggtgaggac gtgccgcgtg gtcagggcgt cgccgacgaa
     7681 gaccgcgtcg gcgaccggga cgtgcaccgc cacgctgccc ggggagtgcc ccggcatgcc
     7741 cacgatcacc gggcttccgg gcaggtcgag gacgtcgccg tcaccgatct cggtgacctc
     7801 gccgacgtag cgggggcgca ggccgttctt gcggatggag tagccgaaga acccgagcgt
     7861 cgggccgagg cgcatggggc cgaccgccac cttgggtttc tcccccgtgc gggcgcggac
     7921 ggcgtcggcg gcgtgcacga acaccggtac gccgtgtgcg cgtcgcaggc gttcggcgaa
     7981 gccgatgtgg tcgaagtcgc cgtgggtcag cacgagcccg cggatgtcgt cgacggactt
     8041 gcccagagcg cggagttcgt gctgcagatc ccgccagtgg ccgggcagtc ccgcgtcgat
     8101 gagcgtgatg ccctcggcgg tgtcgacgag gtagcacgcc acgagatcgt taccgaggcg
     8161 gtgcagatgg ggcgcgagtt tcatcgggac ttccttcgga accctggacg gctatcatgg
     8221 ctaacataat tagccatgat ggctaacgtc aatagctttc gtccgggatg accaacgatg
     8281 ccgacccctg agaagacctc gctgcgcagg atcgtcgccg cgggacgcga tctgctggag
     8341 gcgcacggcc agcaggggct gaccatgcag aacgtcgcgg aacgggtggg agtgcgcgcc
     8401 ccgtccctgt acaagcacgt cggcagccgc gcggccctgc tggcggccgt cgccgaggcc
     8461 accatcgacg acctgatcgc cctgctggag tcgaccgacg ggtcgctcga ggggctggcg
     8521 cgcggctacc ggcgattcgc ccatgcctgg ccgcagggct tccggctgat gctctccccc
     8581 gacgcgccgc ccgaggccct cgcccgcgtg gccgtcccgg tactggacgc ctccaggcga
     8641 ctcgtcggcg aacgggacgc gctcgaagcc gcgcgcctgg tcacggcctg ggccaacggc
     8701 ttcatcgaga tggagctcat cggcgccttc cggctcggcg gcgacgtcga ccatgccttc
     8761 gagtacggcc tggccggcat acgccgagca ctggcgaccg ctccctagcg aacatgggcc
     8821 tgcacgcagc catcggacac ctcccgcccg acgagttcga ggcgatctcc tacgcccgac
     8881 accagcccgg cgaagcctgg cagtcgaccg ctgaggttcc gtgcgtcagg gccatccgtt
     8941 gtcggcgtcc gtgcagtcac ggtttcggcg aggctcgccg cgatgtccgg ttaatgtcct
     9001 gcggagaccc tggaacggtt cccgggctcg ctcaaggatg tccatgtgaa tcatgcgatg
     9061 ttccctgacc catcatcgcg acgccccaac acgctgggag cactgcgatt tggcgtgctc
     9121 ggaacgctgg ccatctggtg ggaggaaggc tgtatcgaga tagccgccgc caagcatcgg
     9181 accgtgctgg cgatcttgct cgccaatccg aaccggaccg tgaacgtcgg catgctcatc
     9241 gacgagctgt ggccgggcct ggctccgagc acggccagga agaccgttca gggctacgtc
     9301 tggcggctgc gccgcgcgct cgggccgttc gccgaccggc tggtgaccac cggttcgggc
     9361 tacaggatgg tcctgcccgc ggacgggacc gacgtcctgg agttcgagag gtcggtcgac
     9421 accgcgcgcg tcgccctcca cgccggcgcg tccgagaggg cggtcggcga gctgacccgg
     9481 gcgctcgacc tctggcgcgg gccggctttc gactgcgtcc cccgcagccc cgccatcgag
     9541 gcgtacgcgg tccggctcga cgaggcgtac gtggccgcgc aggagtcgct catcgcgacc
     9601 cggctcagcc tcggccggcc tgccgaggtg gtgcccgacc tggtcgggct ggctgcggca
     9661 catccccatc gcgagtcgct gcatcgccac ctcatgacgg cactccaccg tacggggcgg
     9721 cggctggacg cgctcgacgt cttccggcgc ctgcgtttcc ggctggccgc cgactacggg
     9781 ctcgagcccg atcggcagac cgtggaactt caccaggcgc tgctccagga ccgcgtcgac
     9841 gtggcgggct tcccccagcg gtgaccgtcc gcccgcccat ccccaccccc tcgtgatcgc
     9901 cgttcccgcg tgagtcggct cttcacggcc cactttggag atcttcagca tgcctgatgc
     9961 ccaccttctg cctccggcga caacgtcgaa ggccaccgcc gtggcaacgg cgatcatgca
    10021 tcgcctgtcc gacgagacgc tcgtcaccga ggtggcgaag gacgcgtcgc gaacgatggg
    10081 cctgccggtc tgggagcctg gagcgtcact gtacgcgggt gccgccggca gcgcgctcgc
    10141 cttcgcgtac gcggcgcgag cctgccccga ctcctccgag cactggtggg cccaggccca
    10201 ccgctggttg aagctggccg ccgccggcac ccgggacaag cccctggtgg tccccggtct
    10261 ctcggacggg accgccggca tggcgctcgc cgtagccgga tgcgacccgg acggccggta
    10321 cgcccggacg ctgagcggcc tgcacacccg gctctccgag caggtcggcc ggccggacct
    10381 ggccgacgac cacgacttct tctacccgga ctacgacgtg atgaccgggc cggccgggat
    10441 tctcggccag ctggcccccc atcttgcgga tcccacggcg ctgcgggtgg cctccggcat
    10501 cgtcgaacgc ctcatcgccc gctgtgacac cgccggccct cgcgagcatg agagcggatc
    10561 gctgcgcacc gcgccatgga aaccctggtt catcgcccgg aagcactacg accgctggaa
    10621 ggaggaggtc cggctcaacc cgtacggctt cgtgaatctc gggctcgccc acggcatccc
    10681 cggacccctg gcggcgctca gccgggcctg gctggccggg caccgtgccc ccgggctccg
    10741 cgaagcgatc cgcgccctcg gcgaccagct cgtcgcggcg tcgcggcacg aggactgggg
    10801 ccgcacctgg ccgcgagtcc tgccgttcga cgaggcgggc gaggtcgcgc cggacagagg
    10861 ccgcccgacc cggccctcct attgttacgg tgctcccggc atcgcctcgg cgctgctcga
    10921 cgccgccgac gcgctcgggg acgacacgat gcggaccgtc gccgtggagg gcttcgaggc
    10981 cgcgctgcgc cagatggagg acctgccggc cgcggcgctg aactacccag ggctgtgcca
    11041 cggcgacgcc gggatggtgc tgatctgccg caagttcgcc acccagaccg gcagcgcggc
    11101 ggcccgatcg gcgctggaac gtctggtcga ccggctgctc ggccactgcg acccggaccg
    11161 ccccctgctc gtccgggact accggccggt gcaggccgcg gagccgggat cgccgtcggc
    11221 tctcgacccg gacggcacct gggtcgacaa ccccgggttg ctggagggcg ccgccggcgt
    11281 cgcgctgacg ctgttgtccg tcgccacgcc cgtacccccc ttctgggccc gggccgttct
    11341 cgtcaactga ctgagtatcc gagaccggga ggaagtcgaa tggcgcagcc tggcagcggc
    11401 cccgtcgcga ccgcgcgggc gtacggcacc ggcctgtacg cggcatcgga cctgttcgtg
    11461 ctccgagcgc ccgtgctgcc cgccgacact ttcgtcaatc tgggcgcgaa cgcggctgtg
    11521 ccggcgcctg ccggcacggc cgagacgctg gccgccgccc gagccgaggg ccgcgggacc
    11581 cttcgcacgc tggccgcctc gccgcgggtc cgccaggcga ttcaggtcgc cagcccgagc
    11641 ctggccgccg cactgcccag actcgacgag aacgtcccgc gggaccgggc cgccgaccgt
    11701 gcgtacgccg cgctgctccg ctacctcatc cggatgtcga cccgccccac ccccctggga
    11761 ttgttcgccg gagtcgcccc cggtgcgttc ctgagcgagc ccgcggcggg cggcgagggg
    11821 atcgcgacgc tggaccgcga cccggtgcgg gccacgcgca cccgagccga cagcgcatgg
    11881 ctggccaacc tggtggaacg gatcgggcgc gacccgaagg tccgcgacaa gctgcgggta
    11941 cgggtcaacg cgctgctgcg gcgcgccggg gacagagccg tgctggtcaa ggccgacggc
    12001 atggacgagc cggagcggat cgagctggcc gtcaaccccg ccttcgcggc ggtgctggac
    12061 ctggcggggc acgagccggc ctacggcgag ctcgcggccg cgctggccca ccgcttcccg
    12121 agcacgtccc ccgagaagat ccgcgctctg ctcgaccggc tctgggacct gggcgttctc
    12181 cttccagacc tgctgccctc cccgaccgag ccgctgcccg aggtgcatct ggccaagcgg
    12241 ctgatcgacc aggacgcccc taccggcgtc atcgacggcc tgacccgcct gcggcaactg
    12301 gctgatggcg tggaccgggg ccacggcgat gtggcgggtc tggcgcggct ggaggcccac
    12361 cagcgggcga tggcgccgga cttcaccggc ccggcgttcc agatcgacac cgcgctcgcg
    12421 ctggagcccg cgaccctgcc cgcggacgtc gccgcggccg cggcggaggc ggcagacctg
    12481 ctgatgaggc tcggctgcgt gcagcagcgg cgcccgcaca tcgccggcta ccacgaggtg
    12541 ttcctggagc actacggcat cgatgcggag gtgccgctgc tcgacgtgct cagcccggag
    12601 accgggctcg gcccgcccgg ttcgtacacc cggcccgccg gccggcatcc atggccgcgg
    12661 caggccgggc agacgcaccc ggaacgtgac cggacgttgg tcgagctggc gttgcacgcc
    12721 gctcgggaag gccggccgac ggtcgacctc gacgacgagc tgatcgaccg gctcaccgtc
    12781 tggcgcccgg acgcggagca cagccggccg cgcacctccc tggacctgtt cttcgcgctg
    12841 gccgccgact cgcccgaggc gatacgggac ggccggtggc ggatggtgct caacacgatc
    12901 ggggtcttcg gcggctggca ggccttcggc cggttcttcg accttttcga cgaggccgcc
    12961 gtgacccgca tccgcgctca gcagcgcctt gaggaggcgc tgcgcccgga tacgatcttc
    13021 gccgagctca actacggggt caggcaccgg ggcgggaacg tggccggcca cccgcccacg
    13081 cgcgaccacg aagtgtgcgt gaacgcggcc gccacggggc cgcccgtgcg gcagattccg
    13141 ctgaccgaca tcgtcctctg cgcagacgcg gaccatttcc acctccgatc cgtctcgctg
    13201 ggccgcaccc tctcggtcgg ccagacccac gccctgaccg ccacgcgggc gcccaacatc
    13261 tgccgtgccc tgctggagtt ctcggaggac ggctacaccc cgccgtgccg gttcgactgg
    13321 ggcgccgcgg ccgacgcccc gttcctcccg cgcctgaccc gcggcaacgt ggtggtgcag
    13381 ccggcgcagt ggacgatcac cgcggcgacc ttcccggcgt gccaggaccc ggacgacttc
    13441 ttccgcgcct gccggacctg gcggcgccag tggatggtcc cccggtacgt ctatctggtc
    13501 gaactggaca accggctcct gctcgacctg gagcacccga cctgggtcga ctggttgcac
    13561 cgccacgtga cccggctgcc ggcccggtcc ggcgagtccg tccgcctgca cgaggcgctg
    13621 ccgggacccg gcgatctgtg gcttcgcgac cgtgccgggc gcccgtatca cgccgagctc
    13681 gcggtgccgc tggtgctgcg ggaccgtacc cggatgccgg agccggccgc cgccaggacc
    13741 gccgcgccgc ccaccacgac gcgccgctgg ctggccggcg acgagtggac ccacctgaag
    13801 ctgtacgccg ccgcggagct gcacgacgcg atcatcacag ggccgctgcg ggagctgctg
    13861 gccgacgacc ggttcggccg cctggtggac cgctggttct tcatccggta cgccgacccc
    13921 ctgccccacc tgcggctgcg cttccacgcc cgcggtcctg agccggccgc ggaggtgatg
    13981 tcgcggtgcg cgacctgggc ccgcggcctc gtacacgccg gccaggccac cgacctcgtg
    14041 ttctgcagct acgaccgcga ggtggagcgg tacggcggcg ggcatgcgat cgactcggtg
    14101 gagaccgcct tctgggccaa cagccaggcc gcggtcgagc tcctccgcct cctgcgcacc
    14161 ggccggttcg acccggacct cgtgcgcgtg gccgcgctcc acgagctgta ccaggcctgg
    14221 ggcgccggcc cgccgccact cgacggcgac ggcgtggcga cgtggatgac cgacgcggcc
    14281 cgcaagcgct tccgtgacgt gcgtcccctg ctctgcgaga tcctcacacc gggcgagcgc
    14341 cgcccggacc atcgcgcgcc ggagtatcgg gccgcgctgg agccggtgtt cgcccggcag
    14401 cggcggccgc tggccgaggc cggccggtgg gtccgcgatc tcgcctcccg cgggctgctg
    14461 accggtggcg agcgcgacat catcgagagt ctcgcgcaca tgcagtcgat ccggctggcc
    14521 gggatcgacc gtgaccagga gcggttgagc tgggcgctgt ggtcgctcag ccggcgcgcg
    14581 atccgcagcc gccccgccgc cacggccgga gccccacggt gaaccgcctg aatgtcctgc
    14641 tgcgcacgat acggcgtcgc cgaagagggc ggtcaccacg agccgatcgc gaccggcggc
    14701 ctctacgccc ggctgttccg gttgcaggcg gccggttacc aggacgagcc aagtgacgcc
    14761 tcacctcggt gaggaaccgc acagggggac gacattgccg aggttgacgg tcggagtcct
    14821 tggtcccctg tacgtcgcgg tcgaagggcg gccgatccgg ctgacagccg gcaaaccgcg
    14881 cgcgctgctg gcggccctgg cgatgtcggc gggccgggtc gtctcggtgg aacggctggc
    14941 cgagatggtg tggtgcgacc ggttcccggc caactcccgg cggagcctgc agaactacgc
    15001 cgcacgcctg cggagcgcca tgggcgatcg gttgatcgaa acgtgcccgg gagggttgct
    15061 gctgcgcgcc gacgcgggtg acatcgacgc gctgcgcttc ctgcgtactc tcgaccgggc
    15121 cgcgcgggct caggactccg atgccgaacg cgggctcctc gacgaggcgc tggccttgtg
    15181 gcggagcgag ccgttcgagg acgtcgattc cccctggctg cgggagagcg aggcgccgca
    15241 cctgatcgag cggcacctgg cggcgctgga gcggcgcgtc gacctggacc tcgtcggcgg
    15301 ccggaagagc cgcttcaccg ccgatctgag gaggctgacc agccggcatc ccttgcgcga
    15361 gtcgttgtgg ctgcgcctgc tgcgggcgct cgtccaggac ggcagacggg cggaggttct
    15421 cgatcggtac gaggaactcc gggcgcggct ggcgcacgaa ctcggcgtgg atcccgatcc
    15481 cgccatccag cggttgtacg cggaacagct cgccgatcat ccgaaggcct acgcggaacc
    15541 gcgcgccgac catccacacg ctcctgccgt tgccggcctc tcggcgacgg gcggtccacc
    15601 ggatcgtccc accgaggtcg catcgctctt cgccacgtcg ccgcggcggc tccctacggc
    15661 cacggcggac ttcgtcggcc gcgaacgcga cctcgcctcg ctggccgccc tggtgcgggc
    15721 ggagccggcg acggcgatcg tggtcgacgg gatggccggc gtgggcaaga cgacgctcgt
    15781 cgtccacaac gcccatcagg tggccgcccg ttttcccgac ggccagctgt tcatcgacct
    15841 gcacggccac acgcctggtt gcgctccggt accgccggag gatgcgcttc atcgcctgct
    15901 ccgcaccctc ggcgtgcccg cggaccgcat cccgccccac ctggaggacc gggccgcgct
    15961 gtatcgcgac ctgctggcag accggaaggt cctgctcgtg ctcgacgacg cggtcggcga
    16021 agcacagatc cggccgctcc tgccgggcag cgcgagctgc cgtgtactgg tcaccagcag
    16081 aagacgcctg acaggtttgg acggaacacg cgcgctgacg ctcggcgtcc cgtcaccggc
    16141 cgacgcgatc gcgatgttca cccgcgtcgc cggaccccat cgggtggccg gcaccgccgc
    16201 gggaacgctg gccgagacgg tgacgcggtg cgagcttctc ccgctggcca tccggctggc
    16261 cgccacgcgg ctgcgctccc atcccacctg gagcgtcgtc cggctcctgg cccggctgac
    16321 cccggcgcgc cggcggctgg ccgagctggc ggtcggagag cgcagcgtcg ccgtcgccat
    16381 cgacatgtcg taccggagcc tccccgaccg cctgcagcgc gcctaccggc tgctctgcgg
    16441 gtacggcttc gagagtttca gcgccgacca ggccgccgcc ctcatgggca cggacaccat
    16501 ggcggccgag cggcttctgg agggcctgat ggacgtgaac ctgctgcagg agccggcccc
    16561 gggccgctac gccttccacg gcctgatacg cgatcacggc gcggagctgg cgatggaaga
    16621 aggcggcagc ccgacggggc gagccgcgcc gctcctcggc ctgccctgcc ctccacgagg
    16681 ggccctggcc gagcacgacg ggtaggcgtg cgggcgccgc agccgcgcct caccatggcg
    16741 gctgcggttg cggcgccgcg tgcacgaccc gtcccgtcag ttgttgcagc agtcgttgtc
    16801 gaagatgcca ctcgcctgga ccccggtcga ggcgttggcc gcgctcgcgt acgacgctcc
    16861 cacgagcgcc agcccggcca cggcggtcgc ggcaaggaat cgtgcgaaga acttcatgag
    16921 ggactccatt cctcagtgag aaccatcgac atcagtaaaa ggccggccat cctcaaatgc
    16981 gcatgggatc tgcctcattt ttcgcatcct ccgagtcagg cgtgatgccg aattgaggca
    17041 gcccgctgat gcaatggaat gcgtgggtgg cgaatcgctg atcgcaccgc gatcatatgc
    17101 aggccggcct gccgaacaga cacgattccg tgtgttcggc aggccggaag agcgaaggtc
    17161 acggtctggc aggcgtgacc tcgcgcagat cgcccgcgct cttccggacc gtgccgtcct
    17221 ggtcgagcac gacgaaggtg ggccagttcc gcacaccgaa cgcctgcgac accgggcctg
    17281 tctgcggttc gacgaccacg cgggcgacct ctcgcacggc gtcgacgatg tccgcgccct
    17341 gctcggccgg tccggcgacc accgccagaa tctgctcccg tccacccgac agtgccttgg
    17401 cgtactcgac gaagcggggc agcgcccggc ggcaggagga acatcccgcg gagaagaacg
    17461 cggcgaaaag cgggcctttc agtccgccca gggataccgt cccgccatcg gtcgcggtcg
    17521 cggtgaaatc ggtgacgcgg tctccggccc ggggcacgga atgacgctcc aagagctggt
    17581 cgagacccgc ccgcgcccat ttgccggtgt actcgcgcaa ccggtgcagc gcaaggagca
    17641 ccagcagcag gttgagcccg cccagcacac cgacgacgac gatcgcggcg gccgttgcac
    17701 catccatcga cacgttcctc cttcagcggg gtagaaccag ggccacgagg tcgtcgtacg
    17761 cgatgaccag tgccgccacg acgacggccg cgaacccgga aacgatcaag gccgccgtat
    17821 cgaacccggc gctccccgtg tggccggtca gcacggttcc cgccaggccc gccccggcga
    17881 tcaccaggag aatcgcattg cgtaccagat gccgcgcccc gagcggccgc gtcgacgtgc
    17941 cgaagcaccg gcaactcgtc gacgtgccac gccgcagggc cgatgcgatc accagtgaga
    18001 agacgatcag cagcgcggcc ccgataccca atcccgcggg cgcggtgacg ccgaccggca
    18061 tcagtgccgc cgcggccagc tcgcacgcga tcaccgcacc ggcggcagcg gaactccagc
    18121 gcggtttcac gccgaacgcg cttacggtgg cacggaactc gatgaaatct cgccgcccgc
    18181 gcaacttact cgcggcagcg gcgacgaaaa ccaacgcgag caatatacgg caaccgaatc
    18241 cgatataagc gatcaacatc tgagtcctca cggcaaaaag ggcgtgcgag tcaccaggac
    18301 ctttccacgc tgtgatcccg ccgaccatga agagccgtac ggccgagccg tcgagatccg
    18361 attcgacacg atcccgatcg ccgacggctc ggcagcggtg agccgcctac gggaaaccgg
    18421 cctcatcctc ggagacaagc cgctccgaac cgaccgtcgc ccgtccgtct gcccacatac
    18481 tcaggcgcag ctccaggggt gagtcgcgca aacggtgatg cacacgcagt tcgaccacct
    18541 gtcgcactcg ccggccctga tctcgccggg catcgacgac acgaggatgt cgaggtcgaa
    18601 ctcgtccatg agagcgatgt ccgccgggtc ctgcgatctt gtgtccagag cgtgcgcccc
    18661 ggcgaacgcg atcggatcgg ccacctgaat cgtgtcgatg gacatggtgt ttccttccct
    18721 gctacgcgtg gctcttctct gcgtcggacg ctagcgagcc cgggtgtggc ggcggtgttg
    18781 ccccggttgt gcgacgcgcg cgcggcgctc aaggtcctgc acgcggacgg cggccgcgcg
    18841 cagcggcggc tggcccggag tgttcctacg gctgctcacc ctggacgagt atgacggcca
    18901 gatggccctg acacgccccg ccgtcgtgcc ggccacggtg aacgacgacg acaggttccg
    18961 ggtgtggggc gtggcaccgg tcagtgaggc gtcagcagga gcacctctcg cgtggtgcca
    19021 ccgtcccggg tgaccaggcg gtacgtgccg gcgtccgtga cctcgacgcg ccagacggag
    19081 ccgcgcccgc cgagcgaacg gccggtgcgc gagtcggcga tccggtagta gccctcgtcg
    19141 atgtgcacga agcgccaggt gtcccctagc cgcttgcggt cggccgggtc ggtgatcagg
    19201 acgtcgccga ccggctggat gcggaactgc tggcaggcct ccccgcgcca ggtgaaggtc
    19261 tgcacggccc catccggccg gtcgcaggcg tcgaggacgc gaccggccag cttgttctcg
    19321 atgcgggacc aaccatggtc ggtgggcagg aaccggaact tctggcagtc gttgtcgagc
    19381 cagccccact gcgccacgcg cgcaccgtcc gcgttgacgc aggcggcgac ctcggcgacc
    19441 ttgttgctgt gccggttgag gatgctcgac cagccgccgc cccgatattc caggcgccac
    19501 tgccggcacg cgtctcccgc ctccgtggct gtcagccgga tgtccgcacc ctcgtagccg
    19561 caggtggagt tgtcgatcga ccccgcaccg tcgtggctca ccagcgtcac gtacgcggga
    19621 ccgcgcccgt ggccacggtt gccgctgagc gggtcgccga ggcgcggcca gccgccgtcc
    19681 cacgagatcg gccgcaccga gcccttgggc agcgcgccgt cggcggcgtc gtagtagtgg
    19741 tggacgtaca ggtccggtcc cttgccccgg cgtagcagga cgtcaccgcc accggtgccc
    19801 tggaagccgt tgtagccgcg cagcagttcg gtgccaccgc cctgcaggag cggccggccg
    19861 tcgcggtcga cgtacgggcc gtggaggctg gtcgatcggc cgacgacgat gcggtagtcg
    19921 gagttgacgc cacggcagca gaagtcgaag ctggcgaaga ggtaccagta ccgtcccttg
    19981 cggacgatcg acgggccctc gatcgccgcc ccgccccggg aggcgagcga gtacagcgtc
    20041 gtgtcctccg tcgacagcag acccgtcgcc gcgtcgaggc ggcgcatctt gatgccgtcc
    20101 cagaacgagc cgaacgacaa ccacggcatc ccgtcctcgt cgaaggtgac gtcggcgtcg
    20161 atcgcgttgt agttgtcgga cgtgcgcgag cgcagcacca tgccgcgatc cacccagcgg
    20221 tagtccggac tgccggggtc gagggtggcg ttggtggcca gaccgatgac ggagttgttc
    20281 gtcccgaagg aggaggcggc gtaatagagg tggtactcgc cgtcgaagta ggagaggtcc
    20341 ggcgcccaga agtcgcccgg cgtgacgccg agctcgtcca ccacccactg cggcggcatg
    20401 gtgaagaccg ttccgaggaa cgtccagtgc accaggtcgg tggagcggcg gatcggcagg
    20461 taggtgcggg tctcgatgtc gccggtgatg atctcgtagt agtaccggcc ctgtctgatg
    20521 agggtcggat cgtgggcgat cggatccgga gagggctgcg ccgacggctc ccccgccgct
    20581 gccaccgggg cagccgaggc ggccgggact cccggcaccg tcgcagccgc accgatcagc
    20641 accccgagca gcaggacggc cacagagccc agcgcgcggg aacggcggtt ccctgacggc
    20701 tttccacaac ccccggccgg atcgcgtgca cccgctcccg ccgtcgtggg tggcggcggc
    20761 gtcaccggga acctcgccgt gccgggcggt gccgtacgtg accgcttcat ggaaccccac
    20821 tcaacgttat ggctgacatt cctcagccag gtcgggagca gcgccgaact cggaccggaa
    20881 tggtggcaag tgttagcgcg aacagagcga ccgtcaagac cgagacggaa tcatccgcgt
    20941 cacgtcgccg acccctccag catcgggctg atggcggcgg ccaacacgac agtggcgcca
    21001 cgccgaagta ggcctcgggc gctcgcagct caccagctca gatcgccaag aaaactgctg
    21061 agcgccgcgt tgacctccgt gggccgctcc agcggcggca ggtgccccgt cgccggcaga
    21121 tcgagccgcc gggcgcctgc gatctcgtcg gccagcagat ccgacaccgc ctggatgccc
    21181 ggcacatccg ccagcccgtt gatcaccagc gtgggcgcgg tgatctcgcg gagtcgctcc
    21241 ttggccgaca ggtgccgttc gggcaccggc cgacggctcc aggagcgctc gaacacctgg
    21301 cgcatcatcg cgaacgccag ctcccacacc tccggatcga gatcgtccag cctccgatcc
    21361 ggcccggcca cctgccacag cgcatgcgcc cgggcaaagg catcgagatc ttcgggaagc
    21421 accctgcccg ccgtgccgct ccgatagcgg gccagcctct cggcgggaac ggtgctgtgc
    21481 acccgctccc gcgcctgagc catcatgtcg tcaggccacg tgtggcccga cagcccagag
    21541 gagatcagca cgagccccgc cacgcggtcc ggagccacca acgccgcctc caccgcgtag
    21601 gagcccccca tcgaatcgcc caccagcgcg gcccgttcca cgccgagtcc gtccatcacg
    21661 cgcagcaggt cttcgtggtg aacgagatca ccggccggct cggccgactc gccgtacccg
    21721 cgccagtcgt aactgatcac gcggtaacga tcggacagga agtcgcgctg gtggcgccac
    21781 atccgccgat cggcaatccc cgcgtggacg agcaccaccg caggaccctc acccacctcg
    21841 tcacaggcca gaccatcgat cctcgtcacg cccagatcgt atgagtcgca ccgcagcttc
    21901 tcgactgggt tcgcagtcgg cgtattgcgc gcccatgtcc acacccttac gcgttgtccg
    21961 tcgggcccat gaaagaggtc gagccgctgg ttcgccaggt gctcgcggag agtggcttcc
    22021 cggccatcga cctccagcgc gagccgtggg tggtcgctcg ggatgtggcg caggccgtgg
    22081 cggagggcac gcttcccatc ggcaagggtg cagacttctt gatcctcgaa ctcagggaaa
    22141 aatggaccac ccccgaggag atctgggaac tgaacctcct catcgacgac gggaaagccc
    22201 tgcgtggggc tccgccggct gacggcgagc ttagacagca ggcaagcaag atcgccgaag
    22261 ccgcaccggg gtggcgcgac gcgccgcagg atccggacct gctaccgccg gactagaagc
    22321 aagatctttc agtgccgcag tcctgttcgg ggtcacgtcc cgcggagacg agggccatga
    22381 agcctcctga tgggcctccg gctgaaagtt tccccagcca cagcccctcc accagcgccg
    22441 ttgtcggcgg ccgtcaccgc gcacgctccc ctgatcgccg gatggcgtac cttactcccg
    22501 ctcacccaca tccgcgtcag agggagtcgt cgtgcgtaca tggttggccc gcgccgttgt
    22561 gtctttcctg atggtgccgc ttacggccgc cccggcggcc tcctccgcct cggctcacac
    22621 ggacgcgcgt acgtgcgcga gggcgaacct gctgttctgc gaggacttcc aggcgatgcc
    22681 cgtcggcggc gcgagcagtc tccgctgggg aatcgacacc aagcacggca cgctcaccgt
    22741 cgagcgcgcc gggcggcggg ggcagaaggt gctgcgcgtg cacaccgagg gcaacggccg
    22801 cgcgttcctg aaggtggacg acttcgccgc gccgggcaac agcttctacg ggcgcgtacg
    22861 gttgcgggcg agcgcgttcc cgaccgcgcc ggactgggcg cactacacgc tggtcgaggc
    22921 gaccggcgac gggccggaga tcgtccgccc gctcggcggc cagtacgccc cgccgcccca
    22981 cgggggagcc gcgtactggg gcgtcggcgc ggacggcggc cccaccgggg actggacgaa
    23041 ctggcagacc accgcgccct ccgtcgccgg gacatggacc tgcgtggagt ggcacatgga
    23101 cgccggcgac aaccggatct cggtgtggtt cgacggggtg gccaagccgg agctcaccgt
    23161 gtccacccgg gagcacggcg gcaacccggt ggacttcgtc ttcccgcggt tcgacacgat
    23221 caagctgggc tggcagctct accaggagaa cccgaccccg gccggctacg acgtgtggat
    23281 ggacgacatc gcgctgagca gccggagagt gggctgctga tcctcgtctg cgactcgccg
    23341 ccgtcgccgc gtccggtttc ggcccggccg cgggcgcgtg cggcgcccgc accacttcgc
    23401 cggacacccc ggagggcatc gggccgaagt gggtgcgtga ttggagccgc gccttccctc
    23461 gtaggcatcg ggcctaggtg gcgacgagct ggcgggtgat gctgggatcg ctgatcctgg
    23521 tgtcgtccgc cagcaggaac gccttggaca ggatgaccga cagcattccg ccgtcctcct
    23581 cgaacggcag gaacaccgac gaggcggcgc ggtcgcggac ggggacgatg cacaggtagg
    23641 cgtcgttcgg ctccatcagg atgttgcccg accccagatg gatccggtag gtgcgcaggt
    23701 gcccgcgcac gcgcaggaac cggtccgtca actccacctg gtcggcgatc ttcagccggg
    23761 gcagcagccg ggccagcgcg tcatgccgcg tgcgggcggt ctcgctcagc tcgccgaacc
    23821 cgtacgactg ccagtagccg tcgtgcccgg ccgccgcccg ctggtcgagc cccagggacc
    23881 cgacccccac agcgaggtcg gcgtcgcgca gcagctccga gaacaccagc ggcggcacgt
    23941 cggcgaccgg cgcgtcgccg ggaagatccg cgtggcggaa ccggatcgcg tcggtggcgg
    24001 cgcaggaggc cgtgccccag gcgtcctgct cggggtcgga ggcgacccgc atgccccagc
    24061 tcgcctgcca gccggcgagc gtcttgacgg ccgccccgac gtcgccgtcg cactcgtagt
    24121 cccagtgacc gatcgacagc ccgctccagc cgcgctgctc cagcagcgcc ttggcctgcc
    24181 cgtagcgcac gaagtggccc ttgaaacggt cggagtgggt gcgggtgcgc tcctcggccg
    24241 gggtgagcag gtagacctcg cggaacgcct gcttgaacgg ctgcctgatc ccccgttcca
    24301 gcaggtggtc gcgccagccg cgcaccccct cggcgctctc caggatcggg tgccacaacc
    24361 ggacgggcgt gtcggcgccc ggacgtgcgg tctcgccgct cgcgtcggcc agtgcccagc
    24421 cgccgccgct cctgaccggc agcccggcga acccgtcggg gagccgccag atgagggcgc
    24481 gggtgtaggg gccggtgacc ggatggtcga agaagtactg ttcggcctcc tgccaggaca
    24541 gctcgcgttc gacgatgagc atctgctcca ggcgcagccg ctcggcggcc tgcgtgcgct
    24601 tgaggtcttt cagcgtggcc tt
//
