LOCUS       NZ_CP045572            25142 bp    DNA     circular CON 07-NOV-2024
DEFINITION  Nonomuraea phyllanthi strain WYY166 chromosome, complete genome.
ACCESSION   NZ_CP045572
VERSION     NZ_CP045572.1
KEYWORDS    RefSeq.
SOURCE      Nonomuraea phyllanthi
  ORGANISM  Nonomuraea phyllanthi
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Streptosporangiales; Streptosporangiaceae; Nonomuraea.
REFERENCE   1  (bases 1 to 11273186)
  AUTHORS   Ou,Y. and Wu,Y.
  TITLE     Nonomuraea nitratireducens sp. nov., a new actinobacterium isolated
            from Suaeda australis Moq. rhizosphere
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 11273186)
  AUTHORS   Ou,Y. and Wu,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (15-OCT-2019) School of Life Sciences and Biotechnology,
            Shanghai Jiao Tong University, Dongchuan, Shanghai 200240, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. Aug-2018
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 160.0x
            Sequencing Technology             :: PacBio RSII; Illumina NextSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_009497075.1-RS_2024_11_06
            Annotation Date                   :: 11/06/2024 06:36:57
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 10,403
            CDSs (total)                      :: 10,325
            Genes (coding)                    :: 10,209
            CDSs (with protein)               :: 10,209
            Genes (RNA)                       :: 78
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 60
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 116
            CDSs (without protein)            :: 116
            Pseudo Genes (ambiguous residues) :: 0 of 116
            Pseudo Genes (frameshifted)       :: 22 of 116
            Pseudo Genes (incomplete)         :: 104 of 116
            Pseudo Genes (internal stop)      :: 8 of 116
            Pseudo Genes (multiple problems)  :: 13 of 116
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 17:05:15
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3539424
            Orig. end                         :: 3564566
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP045572.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..25142
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="7"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..25142
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25142
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:15142](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..15142
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    370..385
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.82"
                     /tool="antismash"
     gene            833..1063
                     /locus_tag="GBF35_RS16170"
                     /old_locus_tag="GBF35_16165"
     CDS             833..1063
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="GBF35_RS16170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GBF35_16165"
                     /product="hypothetical protein"
                     /protein_id="WP_139638405.1"
                     /transl_table=11
                     /translation="MNSQVGMMLASRPFGKTDNVSQAKADWDPVPTAECVSPLVSFHCE
                     YAKSWIYVKHDWGLSMQVSEKHALIDMLASC"
     gene            1196..1387
                     /locus_tag="GBF35_RS16175"
                     /old_locus_tag="GBF35_16170"
     CDS             1196..1387
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="GBF35_RS16175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GBF35_16170"
                     /product="hypothetical protein"
                     /protein_id="WP_139638406.1"
                     /transl_table=11
                     /translation="MTLEPTPPERDPDLSDVWDEMQPSERLGYLMHDGELVPPAVSESV
                     WQMYRDLQEQPGREGNSA"
     gene            1384..1944
                     /locus_tag="GBF35_RS16180"
                     /old_locus_tag="GBF35_16175"
     CDS             1384..1944
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="GBF35_RS16180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GBF35_16175"
                     /product="hypothetical protein"
                     /protein_id="WP_153262152.1"
                     /transl_table=11
                     /translation="MIMLPTVNWDAVATAAVAAIIFNLALDYLAKPRLEARKEEILEAH
                     RLRRELLASAIRITYAAAIVSAVIPDGADSTVRGNVYVEQDRQHDRLQAEVQQLADDGG
                     RHAGTFLGSLLNLVVGYVSALQGLLMSARPRTDQAVEIQKLAGAMAIALSSPRRWQIGK
                     IVARARALEEVRRLVSGHTGVAL"
     misc_feature    1522..1524
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(2319..2936)
                     /locus_tag="GBF35_RS16185"
                     /old_locus_tag="GBF35_16180"
     CDS             complement(2319..2936)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024952.5"
                     /locus_tag="GBF35_RS16185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBF35_16180"
                     /product="2'-5' RNA ligase family protein"
                     /protein_id="WP_226899884.1"
                     /transl_table=11
                     /translation="MEETTTRDHWWWRPGWRVGRSYYTWHILVEDQPAIHEFAQALQPE
                     LAATGVLGPIPLEWLHMTMQGVGFADEVSDEDLHAIAAAVSARVAAVGPVPVTLGPPVV
                     DPEGVNLPVRRIEAVNAVRLAVRDGIADVWGTDRVSEAADRFRPHVSLAYSHSTGAPLA
                     PIQNILAQHTTEIPVVVNRVSLIDINRDNGIYWWRLIQHASL"
     gene            complement(2914..3648)
                     /locus_tag="GBF35_RS16190"
                     /old_locus_tag="GBF35_16185"
     CDS             complement(2914..3648)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1115: HAD-superfamily hydrolase, subfamily IA,
                     variant"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024811.5"
                     /locus_tag="GBF35_RS16190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBF35_16185"
                     /product="haloacid dehalogenase-like hydrolase"
                     /protein_id="WP_226899825.1"
                     /sec_met_domain="HAD_2 (E-value: 8e-07, bitscore: 28.5,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLWDIDHTLIDTRGVGRELSAQAFEQVTGVPMLKQAKIDGITESV
                     IFRETARLHGLHTDRHDFERFASALTKAHLARAAELRERGHALPGAAAALNALSAIPGV
                     VQTVLTGNVRMVAEIKLQVFGLDRHIRWDIGAFGEDDDVRAELVRIALGRATSVFGEPV
                     APGNATLIGDTPADVEAALENGVPVIAVASGRSSADDLRDAGAVRILPSLGNTDSVVTM
                     VQEATTSQVERRALGSGRDHDA"
     gene            3779..4981
                     /locus_tag="GBF35_RS16195"
                     /old_locus_tag="GBF35_16190"
     CDS             3779..4981
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1148: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF024949.5"
                     /locus_tag="GBF35_RS16195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBF35_16190"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_139632804.1"
                     /transl_table=11
                     /translation="MSVSALPIGERIRYWREKKHRKQAAVAGLCGITEEYLSQIERGLK
                     IPSLPVLQALAAELGVPVSALLGEKRNELLAENAYVADSVVTALMGYGPAGSAQPVTLA
                     ELRERVESVWRIWQTSPKRFTEAASVLPALIVDTENAIRAHRLSSDSAARRDVLRTAAD
                     LYFMLRSYCRRAGRVELSLMVADRALRAAEDADDPIRLSAAQWNLGHVLLADGEYEGAK
                     QVALRGIEGLRALPRDADTIAMAGALELVAVVADARRKRWGQARERLSSNATPRAQQVG
                     EGNTMWTVFGPTNVELHAVSIEMEAGEAAEALRVADQIDTSHLPSIERRFTFLLEVARC
                     YDLRREDPAVLVHLLDLEQMAPEDLARNPLARNMVTRLRRRVRATYRRQVDALAERLSS
                     V"
     misc_feature    complement(3811..3826)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 23.43"
                     /tool="antismash"
     misc_feature    5192..5207
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.81"
                     /tool="antismash"
     gene            5619..6404
                     /locus_tag="GBF35_RS51805"
     CDS             5619..6404
                     /EC_number="2.1.1.-"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1292: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF016550.5"
                     /locus_tag="GBF35_RS51805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SAM-dependent methyltransferase"
                     /protein_id="WP_193318583.1"
                     /transl_table=11
                     /translation="MINPFIATPSRTYASLRGAENDALAADREAVAELRAAIDRVDDVV
                     RENAEALIRAVRYLTGIGFDQFADLGGGRPMQGLDARKLPDLAVVAAHEQPETRWLLID
                     SDITAITAGRALLRGIAQAEQADLRDTTKVFQAVEAHLDLDRPIAVILGAVLHFLTDQE
                     AAQLMADLWDRLPAGSMVVVTHLTSTGVDPEVVAHGKATYEAQHDIRIYPRTVGEITAL
                     AGNFAIADPPSVVRTIEFMPEEGPSPEEAPHFLMWMATR"
     gene            6557..7465
                     /locus_tag="GBF35_RS16205"
                     /old_locus_tag="GBF35_16200"
     CDS             6557..7465
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="GBF35_RS16205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GBF35_16200"
                     /product="hypothetical protein"
                     /protein_id="WP_153262153.1"
                     /transl_table=11
                     /translation="MSDFPELARLPYTIRQLIVKGPTGPIDRIQPVSTSRHGLALHVYG
                     TRQAVFLRATPMRSPDLLLYKRERSASLSLPLDAPAPRLLWTTAVDGWLVLAYELINDN
                     ADHAFLSPDPESLDVPLVLDAVQRLGKVLTPGTDERARPVFDLVTSMWAMANHMLNKAP
                     TVLRGRDLFEDALHGFDLEALQGDTLLHGNLSPRHLRIKDGQVYAVDWSQACRGAAGVD
                     PALLAPHFVEAGYSPEHTEALMASIPAWNELPAAQAAGLTALWTLARLYAVEHGHQVRR
                     PEQTRLSDAGRAWLAHLLARL"
     misc_feature    7346..7348
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            7660..7971
                     /locus_tag="GBF35_RS16210"
                     /old_locus_tag="GBF35_16205"
     CDS             7660..7971
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="GBF35_RS16210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GBF35_16205"
                     /product="hypothetical protein"
                     /protein_id="WP_139632807.1"
                     /transl_table=11
                     /translation="MLARDEAAADEVARQTVQELELVAHGWFHVEYSLHRREFIAYYRG
                     RDCPPGGLILRAAVPDQLLTLMDRVAPPGWRMPDLPVMSARQASRLTRYGAPGNRRSG"
     gene            8017..8283
                     /locus_tag="GBF35_RS16215"
                     /old_locus_tag="GBF35_16210"
     CDS             8017..8283
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="GBF35_RS16215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GBF35_16210"
                     /product="hypothetical protein"
                     /protein_id="WP_139632808.1"
                     /transl_table=11
                     /translation="MTATSYVYGREIDGSHERWVILVAVPVRGGTLLHEEHTRSGPNNS
                     RRMLLNRIVPLPAGTTVETWLQERDQELQASGWDPPNRVAGFC"
     gene            8451..9653
                     /gene="fxlM"
                     /locus_tag="GBF35_RS16220"
                     /old_locus_tag="GBF35_16215"
     CDS             8451..9653
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Methyltransf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR04364.1"
                     /locus_tag="GBF35_RS16220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBF35_16215"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_226899826.1"
                     /sec_met_domain="PCMT (E-value: 2.3e-45, bitscore: 154.2,
                     seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="Methyltransf_3 (E-value: 2.1e-05,
                     bitscore: 23.1, seeds: 4, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTIDNDVQDASALRAAMVRELREQGAIQSERVAAAIATVPRHLFT
                     PGETLETAYAANTAPIVKADANGMTLSSVSAAHLQATMLEQAEIEPGMRVLEVGSGGYN
                     AALLAELVGESGRVTTVDIDPDIVERAGTFLREAGYDHVHVVLADAEQGLAMSAPYDRI
                     IITAGSWDIPPAWIEQLTDTGRIVVPLRFAGVTRWIAFDRDRSGLVSRGYGLCSFVPVQ
                     GAGSHTERAVSIDDGVVLRLDDDTLTVDTDALRRALHLPRIARWSGTAFDMPDEVVLFL
                     LTTDPHMTMLHADQRRVDQELLAPSTLRGVPALISGDSFAYRTRRENDQTGGYESGVYA
                     HGPAAEQVAARYVELLRQWVSEYHRRGAASIRYIPMPANAPTLSAGVFAKRHGTVVVTW
                     P"
     gene            9708..9905
                     /locus_tag="GBF35_RS16225"
                     /old_locus_tag="GBF35_16220"
     CDS             9708..9905
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR04363.1"
                     /locus_tag="GBF35_RS16225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBF35_16220"
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_139632810.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 1e-14, bitscore:
                     53.4, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSMTQLNPPVAAALPVPPRNTGWSDDEWTDLDVSIIESGVAAEQL
                     IRMTDDGCNSTCATACNSCP"
     CDS_motif       9708..9836
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MSMTQLNPPVAAALPVPPRNTGWSDDEWTDLDVSIIESGVAAE"
                     /locus_tag="GBF35_RS16225_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9837..9905
                     /prepeptide="core"
                     /locus_tag="GBF35_RS16225_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="-8.50"
                     /molecular_weight="2214.5"
                     /monoisotopic_mass="2212.9"
                     /core_sequence="QLIRMTDDGCNSTCATACNSCP"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSMTQLNPPVAAALPVPPRNTGWSDDEWTDLDVSIIESGVA
                     AE"
                     /leader_location="[9707:9836](+)"
                     /alternative_weights="2232.5"
     misc_feature    9714..9727
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.41"
                     /tool="antismash"
     gene            10001..13069
                     /locus_tag="GBF35_RS16230"
                     /old_locus_tag="GBF35_16225"
     CDS             10001..13069
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.5"
                     /locus_tag="GBF35_RS16230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBF35_16225"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_153262154.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 2.7e-194,
                     bitscore: 646.2, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 7.2e-18,
                     bitscore: 64.3, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.4e-26, bitscore:
                     93.0, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYHYLNTAVLRAPAWRPDQPPPSWPDLTGSDAGPTSWRAWLARTW
                     QAPGFAAAVEQASPDLARRVRTILDGRPVPVPAVRRAVLAVMRYLLRASTRPTPFGLFA
                     GVAPARISTATDLPEVRIGDAHRPIARVTAEWLAAIVQRLEGETALQRRLTVVANNFAF
                     ERDGRLVLEHRASTEAGGAPGEVSVRATAPVREALRLARDPLPVADLVARLSGTSPHTP
                     ERSIEALVAELVAQRLLLTSLRPPMTTCDPLRYLLHELDAVDAEDISEVADIVKGLRGI
                     AEELTRHDHAPATAAGGHRARAAAAMTALHPATRPPLTLDLRLDGHVMVPAAVAAEAAA
                     AAAALVRLARRLALNAGWLAWHERFLDRYGLRALVPLRDVVDADTGLGYPPGYIGAPGL
                     GGEVLTDRDSTLLALAQNAAVRRQREIRLDDDLIAQLSPVDTQTLIQPTTELTVRIDAP
                     STQALAEGTFTLAVTGVSRTAGTTTGRFLDLLDPADRQPMTATYAKLPTGVRDALAVQV
                     SAPSPYTSTENVARVPQVLPDLLPVGQYPGARPVALDDVAVTADRHGIYLVSRSRRRVV
                     EPVALNAVNPRQHTHPLVRFLLEAPHALRAPCAGFDWGAAAALPFVPALRYRRTILSPA
                     RWRLTTADLPAPAAVWQEWESTLTRWAEQVALPQTVSLGGGDQHLRLNLAEPAHRALLR
                     AQVDRAGTVVLRAAPEPEAAGWIGGGAHELVIPLATTLPPAEPPPLPPTVTRRSHGRLP
                     GQDGRLSVKVYGHPDRHDAILTRHLPRLTEALGSDAPWWFLRYHDPDHHLRIRLTVPTG
                     AFAATAAEVAAWSEQLRRARLTGRVQWDTYFPETARFGGPDAEAAAEAYFAADSAAALA
                     QVLAVTSLGGPHLHALAAASMLDIAAALLADRAAAMRWLIDHTRPDASAPDRAIYEQAV
                     RLAAPDDHAELHAAQPAGEQIITCWERRRRTLAAYRRTLEETGTPPAVVLPDLLHLHHV
                     RMAGPSLSSERACLHLARAAALSWTNRPTRSRP"
     misc_feature    10028..10030
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     aSDomain        10463..10738
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_GBF35_RS16230_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="1.90E-20"
                     /identifier="RREFam001.1"
                     /label="GBF35_RS16230"
                     /locus_tag="GBF35_RS16230"
                     /protein_end="246"
                     /protein_start="154"
                     /score="64.3"
                     /tool="antismash"
                     /translation="TVVANNFAFERDGRLVLEHRASTEAGGAPGEVSVRATAPVREALR
                     LARDPLPVADLVARLSGTSPHTPERSIEALVAELVAQRLLLTSLRPP"
     misc_feature    10964..10966
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            13066..14301
                     /locus_tag="GBF35_RS16235"
                     /old_locus_tag="GBF35_16230"
     CDS             13066..14301
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.5"
                     /locus_tag="GBF35_RS16235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBF35_16230"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_139632812.1"
                     /sec_met_domain="LANC_like (E-value: 5.9e-38, bitscore:
                     129.8, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAPQPHALAVAGSIATALADPQPWVAEPPGNGRIWPQSLAGGAA
                     GIALLHIERAHSGHGDPATAHAWLHVAASGALTAAANAGLFFGAPALAFVTHAAADDSG
                     RYRGALARLDDAVMTLTRTRLTAAHARIDCGERPEMKEFDLIRGLAGLGAYHFRRHPDH
                     PITGEVLSYLVRLTEPLPAGGELPPWWTSVAPNGEPSSDYPHGHGNLGMSHGICSALAL
                     LSLAVIRNAGVAGVKEAIEAICGWTDTWRQHDDAGPWWPGYITHDQACTQRVDPSQRPR
                     PSWCYGISGTARAQQLAGMALGDHTRKQAAEAAMLATLRDPAQLDRLPEIGLCHGTAGL
                     LQAAWWMAADAHTSQISAELPNLAHRLTEQLSRSLPGPELLDGAAGAALALHTIGTGIA
                     PASRWDTFLLLA"
     gene            14318..15142
                     /locus_tag="GBF35_RS16240"
                     /old_locus_tag="GBF35_16235"
     CDS             14318..15142
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017576943.1"
                     /locus_tag="GBF35_RS16240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBF35_16235"
                     /product="thiopeptide-type bacteriocin biosynthesis
                     protein"
                     /protein_id="WP_153262155.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.7e-37, bitscore:
                     128.9, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDTCPWRQVNLAFPDWASAEHIAVTHLAPLLEAAEHERLITAWFF
                     MRKRPCWRIRYAPSSGRTQPHFRAHLNNLIRQRHIDTATEAVYEPEQHAFGGAEAMWCS
                     HDLFHLDSRHLLHHLTHSPGMQRRRELSILLCTVLLRAAGLDWYEQGDVWARVADHRDL
                     PSPIPPEQRRPLEAGLRRLMSVDAGPLLRDGAPLGFAAEWAAAFAAAGSQLARLASSGL
                     LHRGLRAVLAHHIVFAWNRLGMPYTTQAVLAHTAKQVVFGPVPARHHRTTEE"
     gene            15149..16300
                     /locus_tag="GBF35_RS16245"
                     /old_locus_tag="GBF35_16240"
     CDS             15149..16300
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="GBF35_RS16245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GBF35_16240"
                     /product="hypothetical protein"
                     /protein_id="WP_139632813.1"
                     /transl_table=11
                     /translation="MDVVLEQAAQRFPLIPRPRPACPPLTARVAALCDLADAAAHRADA
                     DHLALAAETLNKAALIASDCGVPGLARSLCWRHFTIYRLGWPLGGQHARRALEPLVNLA
                     RLAIRAGNGFGGYQLIENLLHAVSSGGRADIDGRPVSFDSFTRTSDDLRMVRQWLYGVF
                     VAEGIRALISSSRWQDAVTHAQQYRGVGERLLDGRQAAVVAHCLAGHADTAAALLAGST
                     LVQPWEHAVADCLAMLCDRSAGHSTSNIGADLQRHYLELDRTPELVVFRTRLGLTILDL
                     ADADRPLTGQVFACLISDLIATADGYAARDALSHQGCRTRLTTRQQRALASAVESAGLR
                     AEAIPQPLVRYLHTAVEIGEAVLARSLDAAAVEATAPASTVRS"
     gene            complement(17012..18844)
                     /locus_tag="GBF35_RS16250"
                     /old_locus_tag="GBF35_16245"
     CDS             complement(17012..18844)
                     /EC_number="3.4.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S9"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012546.5"
                     /locus_tag="GBF35_RS16250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBF35_16245"
                     /product="S9 family peptidase"
                     /protein_id="WP_194244261.1"
                     /sec_met_domain="PF00561 (E-value: 7.6e-06, bitscore: 25.0,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_S9 (E-value: 3.4e-39, bitscore:
                     133.7, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPGYLDFVPQQRFQPTLALSPDGHLVAYSSHASGHYDLWVVPVTG
                     GEPRRVAGFDDRAVRQIAWTPSGDRLVFTADENGDEQFRLYLVALDGSDLTEISSGPDC
                     QRVLATSPFDPTGRFLAYTANDRDPAAQDLIVHDLQTSELRRFTPSQGVAFEAASLSPD
                     GRWLLATGFRSNTDIAIYLINLSDPDAEPVCLTSDLGEGVFEPGVWAADSSGFHLLTDH
                     WSEFTAAAFYDLAASSLQAIARPKWDVEVLDAAAGVRIWSVNEGGSSLLHADRDGSPVS
                     LPGIPPGVISALSLAPDASFAVLLINSAARPAEIAVLDLARHEFRYLTDTRPPALHVID
                     PVAPELITYPARDGRDVHALLYRPDGPGPHPVLLSIHGGPESQERPLYARSGLYQHLLH
                     QGIAILAPNFAGSTGYGTAHQKLIYCDWGGIDLDDLDHAVKYLHALDWTDPNRLAVMGA
                     SYGGFAALSCLARLPYPWAAGVSICGPSNLLTLAKASPPTWKTFVATVLGDPDTRAEQL
                     LERSPVTYADGITAPLFVLQGAHDPRVPQAESDQIVARLRERGVEVRYDIYPDEGHGFT
                     NRANELTAYEAISAFLHNHLIATTADRPEPLHVG"
     gene            complement(18864..19871)
                     /locus_tag="GBF35_RS16255"
                     /old_locus_tag="GBF35_16250"
     CDS             complement(18864..19871)
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012422.5"
                     /locus_tag="GBF35_RS16255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBF35_16250"
                     /product="LuxR C-terminal-related transcriptional
                     regulator"
                     /protein_id="WP_153262157.1"
                     /transl_table=11
                     /translation="MTVDGQDQVKAKRLLEGVVPEEIFVSYSMLLTEGGCPEDDAASLL
                     GSSEQVAELTARGMAHRRPDGPAMPPRLVPAPPELALQGVLTDLSRRLVNDQERLLAGH
                     KRLSEFHQTPAAASSNSAMDRLVQIVTDRDEISSLSYALINAARHDWLTLDNYVLEAPV
                     EDSTGYAPLPVFEGRVQCRAIYETRCAEHPIGAKTIEAAVEAGEQARLLPRIGMKMKLA
                     DEAVALLPLTPTGMGGALLVRSPVIVGALREYFELLWEKAIPFGSAKAAAPLTPAQLQV
                     LQLLNQGLPDEAIARRMDISVNTMRRHWTAIRDELGVETRFAAGAAAVRRGWID"
     gene            20129..21898
                     /locus_tag="GBF35_RS16260"
                     /old_locus_tag="GBF35_16255"
     CDS             20129..21898
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015649.5"
                     /locus_tag="GBF35_RS16260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBF35_16255"
                     /product="bacterial transcriptional activator
                     domain-containing protein"
                     /protein_id="WP_153262158.1"
                     /transl_table=11
                     /translation="MRQLVEDVVRKLSAAVAASMVLGASSPAGALANAEPYCPQVGRAP
                     RQVYDIEKFCELVYGDLMEGRAPNLLELLARSQRIPVHTSLASKSQKVSKSHDVRSTVK
                     RPEAEPARFRRSDFEPRMPGEGGREAGRAPGRALNRDRRASVDRQKRSRRNGRKPSSTT
                     VPTPPAAPSETPSASASTSFPVPAAVSSAPAPAPAPASRDAVRPKSEHLSEAMGPLGAA
                     LAFGLMLMVLSAALIGRLRSWPAQASADSSAVALSGGIDGRNGEEAELRPAVVLASAGA
                     QAPVVDCVTAEAVAEPDRREHLAVTTSQPDQPSFRPAVAKVGAEAETEEPFVQGASVDL
                     GSGFLAAAGKAKVEVLGVPRLSYGRSDISFGRAEARELFALLSVSRDGVSAEGIAETLW
                     PGEVGGRRLDSAVREINRAMRQAVGCRAGVRFVLKSGERRLLPAASFDADFWRFEDACK
                     LASIAAEDAVRMAALHEVLALYRGALLAGCDDLWVLPLRQAAQRQAADAAERLAELVRA
                     DDPGRAVDVLRLAVERIDPCSETLWCLLMSVQGELGRLPAVRRSFELLRERLSEIDAVP
                     STQARQVYERFMR"
     gene            complement(21955..22344)
                     /locus_tag="GBF35_RS16265"
                     /old_locus_tag="GBF35_16260"
     CDS             complement(21955..22344)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="GBF35_RS16265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GBF35_16260"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_139632817.1"
                     /transl_table=11
                     /translation="MSGTGYRTLLDCRRRSRYLRQHGFTVDQIAVILGLDHPATPLRLY
                     RYAAGLTAAQTIEAFHQFAGTIGAGLRESRLYDYENWPQAGRRPSVSTLRLLARIYGTR
                     PAHLLTAETLATYARHDQRILHEEG"
     misc_feature    complement(22365..22379)
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: medium, score: 21.93"
                     /tool="antismash"
     gene            22724..23329
                     /locus_tag="GBF35_RS16270"
                     /old_locus_tag="GBF35_16265"
     CDS             22724..23329
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="GBF35_RS16270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GBF35_16265"
                     /product="ATP-binding protein"
                     /protein_id="WP_153262159.1"
                     /transl_table=11
                     /translation="MRSEFPNSQPDDVLAELRSTQYEGMWWRRAFAGQGDQAAPARLLV
                     ALLLGDTCWGQDAEWVAAELISNALRHTDSGVAGGFFVVEVARTPRKARLVVHDLGGSG
                     TPDFGRAVKLAEQRKPGQYEDGYGLASVARVASRVGVSGDPIGGHAVWAEFDLIASGDE
                     EHQRRGEGDRNREGAAPPDYEPTALRQSALALTACQRP"
     gene            complement(23416..24189)
                     /gene="istB"
                     /locus_tag="GBF35_RS16275"
                     /old_locus_tag="GBF35_16270"
     CDS             complement(23416..24189)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene="istB"
                     /gene_functions="other (smcogs) SMCOG1151: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017602408.1"
                     /locus_tag="GBF35_RS16275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBF35_16270"
                     /product="IS21-like element helper ATPase IstB"
                     /protein_id="WP_127934030.1"
                     /transl_table=11
                     /translation="MTSPTPPALPDELDRLLRRMRLPYLRKAAPDVLATARAQRWDPAE
                     VLRILIHEEVTGRDAATRRLRRTSANFPTGKTLASWRPEESSIPEPTQNALATLEWIGR
                     AENLVIAGPSGTGKSHFTEGLAHAAIEKDLRVAWFTLETLTTTIGKAKVDGSIARTVAR
                     ICRADLIVIDDIGLLPAGTDAAEAFYRIIDAAYERRSIAITSNIHPSGFDTIMPKTLAT
                     ASVDRLLHHAHLVLTKGDSHRLAEALAGKGVTPLT"
ORIGIN
        1 gctgcggcag accatcgtgg acgtgatctg ctcgtatctg aggatgccgt acacgccgcc
       61 cgtcgagcag gaccggcatg aggacatccg cgcagcgcag cgcgccgccc gcgcccgcag
      121 gccggcccgc ccggacacga gcggcggccg caatctgcac gaggaaggcc aggtccgtcg
      181 gacggcgcag cacatcctga ccgctcacct ccgctaccag gactccccgg ccccacaccg
      241 ccgatggctc tcccgccagc ccgacggcaa cccgcgccac tggcctgaca tctggatcga
      301 cctcaccggc gcggtcctca tcgacttcga cctccgcgac tgtcgccttg cctccgcctg
      361 gttcggtgat gcgcaatttg ttcaccccgc ctggttcggt ggggcgacct ttacgggcag
      421 cgtccggttc ggcggggcaa ccttctccag cgacgtcgag ttcgaccagg cgaccttcat
      481 cggccgcacg acttggttcg atcaggtcac cttcgccgac ggcgcccagt tcggcggaac
      541 gaccttctcc ggcgaggtcc gattcgacca gaccaccttt gctggtggcg cctggttcaa
      601 cggcgcccaa gggttgcagg aggcctcgct ggccggtgtg cgactgacac cggtggttga
      661 cgaagtggtg cgggagtggc cctcgtgctg gcgggcggaa aggagcgccg acgggtggca
      721 gacgctgcgc ctgacggccg acgcgcaggg caccagcacg accggaggcg agcagagccc
      781 gaagccgttg gcatgacgtt cccaacgctc acgtcacgca cacgtccgtg acgtgaatag
      841 ccaggtcggc atgatgttgg catcaaggcc gttcggtaaa accgacaacg tcagccaggc
      901 caaggccgac tgggacccgg tgccaacggc cgagtgcgtg tcgccgctgg tgtccttcca
      961 ttgcgagtac gccaagagct ggatttacgt caagcatgat tggggtctgt ccatgcaggt
     1021 cagtgagaag catgcgctca tcgacatgct cgcctcctgc tgactgcggc gatgcgatgc
     1081 catgggtccg gccgtcaagg agaccggacc tgtgaggtgc cgtggcttgt agccgctgtg
     1141 cggttctgcc aggaaagttc tgcggacgat caccagcggc aggcaccctg ggccggtgac
     1201 ccttgagccc acaccccctg agcgtgaccc ggacttgagc gacgtctggg acgagatgca
     1261 gcccagcgag cgcctggggt acctcatgca tgacggcgag ctggtgccgc ctgcggtcag
     1321 cgagagcgtg tggcagatgt accgcgatct ccaggagcag ccaggccgtg aagggaacag
     1381 cgcgtgatca tgctgccgac cgtcaattgg gatgccgtcg ccaccgcagc cgtggccgcg
     1441 atcatcttca acctggcgct ggactatctc gccaaacccc gtctggaagc ccgtaaggag
     1501 gagatcctcg aagcgcaccg cttacgccgt gagctgctcg cctccgccat ccgcatcacc
     1561 tacgcggcgg cgatcgtctc cgccgtgata cccgacggtg cagattcgac agtccgtggc
     1621 aacgtctacg tcgagcagga taggcagcac gaccggctcc aagccgaggt gcagcagctg
     1681 gccgacgacg ggggccgaca cgccggcacc ttcctcggat ccctcctgaa tctcgtcgtc
     1741 ggctatgtca gcgcactgca aggcctgctc atgtccgcgc ggccgcgtac tgaccaggcg
     1801 gtggagattc agaagctcgc cggagccatg gccatagccc tgtcttcgcc ccgtcgctgg
     1861 cagatcggga agatcgtcgc ccgggcccgc gctctagagg aggtgcggcg cctggtgtcc
     1921 gggcacaccg gtgtagctct gtgaccgaca aacacgatct tcgcttcccg accgaggccc
     1981 cgcgagcacc cgcctgtttg ggtacgcgat ctgttgagga gcgtggtcgg ttgtggtgat
     2041 gcaggatcca gagggagatt cccgaggcgg agcatgaacg gatcgtggca cgggtggctg
     2101 cgatcggtgt ggccaaggcg tccggcgagg tgtgcaggca tgatcagcga atgccgccac
     2161 cccgcttaac cgcagctcag gacacggaac tcaatgttcg agtggtacag ccgggcgtat
     2221 tcacacccag gatctgggag cgcgggcgac cgaggcgagg gcggggaaga gcaaaccggt
     2281 ggggtgagct ctcccagccc tcatgctctg tcaggagttc acaaggatgc atgctggatg
     2341 aggcgccacc agtagatgcc gttgtcgcgg ttgatgtcga tcagcgagac acggttcacc
     2401 acgactggga tttcggtggt gtgctgggcg agtatgttct ggatcggtgc caggggcgcc
     2461 ccagtgctgt gggagtaggc caggctcacg tgaggcctga acctgtccgc cgcttctgat
     2521 acccggtccg ttccccagac atcagcgatg ccgtcacgaa ccgcaagccg aaccgcgttc
     2581 accgcctcga tccgccggac gggcaggttg accccttcgg gatccacgac tggaggcccc
     2641 aaggtgacgg gcacgggccc gaccgcggct acacgtgcac tcaccgctgc ggcgatcgcg
     2701 tgcaggtcct cgtcgctgac ctcgtcggcg aagccgacgc cctgcatcgt catatggagc
     2761 cactccagcg ggatcgggcc gagcacccct gttgctgcca gctcaggctg aagtgcctgc
     2821 gcgaactcgt ggatggcggg ctgatcttcg acgaggatgt gccaggtgta gtacgagcgg
     2881 ccgacgcgcc agcctggtcg ccaccaccaa tggtcacgcg tcgtggtctc ttccactgcc
     2941 aagggcccgc ctttccactt gggaggtcgt cgcctcctgc accatggtca cgactgagtc
     3001 cgtattccca aggctgggca ggatacggac agccccggcg tcacgcaggt catcagcgga
     3061 gcttcgcccc gatgccaccg cgatcactgg tacgccgttt tccagggcgg cttcgacatc
     3121 ggccggcgta tctccgatga gagtcgcatt gccgggcgcg accggttccc caaacacgga
     3181 tgtagctcgt cctagtgcga tgcgcaccag ctcggcgcgc acgtcatcgt cctccccgaa
     3241 ggccccgatg tcccagcgga tatgcctgtc aaggccgaag acttggagct tgatttccgc
     3301 gaccattcgt acgtttcccg tcagaacggt ctgaacaaca ccgggtatcg cgctcagggc
     3361 gttcagagcc gcggcggcgc caggtagtgc gtggccacgc tcccgcaact ccgcagcccg
     3421 cgcgaggtgc gccttggtga gcgctgaagc gaaccgttcg aagtcgtgcc ggtcggtatg
     3481 caacccatgg agtctagcgg tctcccggaa gatcacagat tcggtgatgc cgtcgatctt
     3541 cgcctgcttg agcatgggta cgcctgtcac ctgctcgaat gcctgggctg acagttcgcg
     3601 accgacgccc cttgtgtcga tgagggtatg gtcgatgtcc cacagcacga ttcggcgatc
     3661 catcattgat tcctccaacc tcacccatcg ctgctccaga ctgtcacaca ctcgtgtaga
     3721 tctggccctg tgcacctggg cccgcctacg ctcgatgcat caataggcag ggggtcggat
     3781 gagcgtctct gcgcttccca tcggcgaacg tattcgctat tggcgagaaa agaagcaccg
     3841 caaacaagcc gccgtcgccg ggctatgcgg tatcaccgaa gagtacctga gccaaatcga
     3901 gcgtggcttg aagatcccct ctctaccagt gctccaagcc ctcgcggctg aactcggggt
     3961 cccggtttcg gctcttctgg gtgagaaacg caacgaactc ctggcagaga atgcctacgt
     4021 tgccgacagc gtcgtcaccg ccctgatggg gtacgggccg gctggcagcg cgcagcccgt
     4081 gacgctggcc gagctacgtg agcgagtgga gtcggtatgg cggatctggc aaaccagtcc
     4141 gaagcgtttc accgaggccg cctccgttct ccctgctctc atcgtcgata ccgagaacgc
     4201 catacgagct caccgcctca gctctgacag cgcggcgcgg cgggatgttc tgagaacggc
     4261 cgcagacctc tatttcatgc ttcgctcgta ttgccgtcgt gctgggcggg ttgagctatc
     4321 gctcatggtt gcggaccgag cgttgcgcgc agccgaggac gctgatgatc cgattcggtt
     4381 gagtgcggcg cagtggaatc ttggacatgt tcttctcgcc gatggcgagt acgagggagc
     4441 caagcaggtc gcgctccgag gcattgaagg tctgcgtgcc ctgccacggg acgcagacac
     4501 gatcgcgatg gcgggtgcgc tggaactggt cgcggtcgtc gccgacgctc ggcgcaagcg
     4561 gtgggggcaa gcacgcgaac gcctctccag caacgccacg ccgcgggcac agcaggtcgg
     4621 cgagggcaac acgatgtgga ctgtcttcgg tcctaccaac gttgaactcc acgcggtaag
     4681 catcgaaatg gaggccggcg aggccgcaga ggccctacgc gttgcggatc agatcgacac
     4741 cagtcaccta ccgtcgatcg agcgccgttt cacgttcctc ctggaagttg ctcgctgtta
     4801 cgacttgcgt cgcgaagacc cggccgtgct ggtacacctc ctcgacctgg agcagatggc
     4861 ccccgaggac ctggccagga acccgctcgc tcgaaacatg gtcacccgtc tccgtcgtcg
     4921 tgtacgggct acgtatcgcc gacaggttga tgccctggct gagcgcctaa gctctgtttg
     4981 atctcctagc tgctggttac ccgaactgac agttcgggtg agtccctctc gccgtcctta
     5041 ccgtcgctgg aaacgtcact cgacgaacag cgatggtgac caatgcaagg gatggcaaac
     5101 acagtccaga ctgccgctgg cacgcaaatc gcggcgatgg cggctgaatg ggatggcatc
     5161 cgtgtgccga ggcacatcgg cctggccatg ctccaacgcc tgtccgacgc cagcctgccg
     5221 gtcatcgtcg atccagcaga acgcgccctg tatttcctgg tccccgtcgg caccgccgac
     5281 gactgggaac tacccgatcg gcgagttctc gatatcaggc gccacgtcaa cctccctcct
     5341 acgcagcggc agatgccgcc tggctgctac tggctcacgt tgccggggtg ctcagtgcga
     5401 tgcgtcggct tgagatcgct acgcacggcg ctggtgggcg tgtggaacat cctgcttgcc
     5461 tcccgagcgg gcacgaggcc agccagcgtg gccgccggcg cgtatgccga tggcatgcgg
     5521 gacatcgctc ggtccggtgc tggtcctgca gtgctccgtc cggctccccg tatccaacag
     5581 aggcccatat gacaaccgaa tccacaggac cgggaagcat gatcaacccg ttcatcgcga
     5641 cgccgtcccg cacgtacgcc tctctgcgcg gcgcagagaa cgacgccctc gccgccgacc
     5701 gggaagccgt cgccgagctg cgcgccgcga tcgacagggt ggacgacgtc gtccgggaga
     5761 acgccgaagc gctcatcagg gcggtccgct atctcaccgg catcggcttc gaccagttcg
     5821 ccgacctggg cggcggccgc cccatgcaag gcctggacgc ccggaaactg cctgacctgg
     5881 cggtcgtcgc cgcgcacgaa cagccggaga cgcggtggct gctcatcgac tctgacatca
     5941 ccgcgatcac ggcgggccga gccctcctgc ggggtatagc gcaggcggag caggcggact
     6001 tgcgcgacac cacgaaggtc ttccaagcgg tcgaggcgca cctggacctg gaccggccga
     6061 tcgccgtgat tctcggggcg gtgctgcact tcctgaccga tcaggaagcg gcccagctca
     6121 tggccgacct gtgggatcgc ctgccggcag gcagcatggt ggtcgtcaca cacctgacca
     6181 gcaccggcgt agaccccgaa gtggtcgcgc acggcaaagc cacctacgag gcccagcacg
     6241 acatccgtat ctacccccgc accgtggggg agatcacggc gctggccggc aatttcgcca
     6301 tcgccgatcc cccgagtgtc gtccgcacga tcgagttcat gcccgaggag gggccgtctc
     6361 cggaggaggc cccgcacttc ctcatgtgga tggcgacgcg gtgaaaccgc cgcgccgccc
     6421 gctgaacgat gcgtgccgtc ccgagcgcac cgggcggccc gtgtcgcacc accgtctcgc
     6481 cccccgggga cgagcttcgt tcctctcccc ggggcgcgag acggccaaca tctttcccgc
     6541 cctccttgga ggaaccgtga gcgactttcc cgaattggcc aggctgccgt acaccatccg
     6601 ccagctcatc gtgaaagggc ccaccggccc gatcgaccgc atccagccgg tcagcacctc
     6661 ccggcacggt ctggccctgc atgtgtacgg cacccgccag gccgtgttcc tccgcgccac
     6721 cccaatgcgc agcccggacc tgctgctcta caagcgggag cggtcggcaa gcctgagcct
     6781 gcccctggac gcgccggcgc cgcgcctgct gtggaccacc gcggtggacg gctggctggt
     6841 gctggcctac gagctcatca acgacaacgc cgatcacgcg tttctgtcgc cggacccgga
     6901 gtcgctggac gtaccgctcg tcctggacgc cgtgcagcgg ctgggcaagg tgctcacccc
     6961 gggcacggat gagcgcgccc ggcccgtgtt cgacctggtc accagcatgt gggcgatggc
     7021 caaccacatg ctcaacaagg cgcccaccgt gctgcgcggg cgggacctgt tcgaggacgc
     7081 gctccacggg ttcgacctgg aggcgttgca gggcgacacg ctgctgcacg gcaacctcag
     7141 cccgcggcac ctgcgcatca aggacggcca ggtgtacgca gtggactggt cgcaggcatg
     7201 ccggggcgcc gccggcgtcg acccggcgct gctcgccccg catttcgttg aggccggcta
     7261 cagccccgag cacaccgagg cgctgatggc gagcattccc gcgtggaacg agctgccagc
     7321 cgcccaggcg gccgggctga ccgcgttatg gacgctggcc cggctgtatg ccgtcgaaca
     7381 cggccaccag gtgcgccgcc ccgagcagac ccgcctctcc gacgccggac gtgcttggct
     7441 cgctcacctg ctggcccggc tctgaccgga gccgtcgatg ctggcgcggc aacccgtacc
     7501 ggtgctgccc tccccgcggg gctgcgctgc tgggccgcgc cccgtgcggg gtgtgcccgg
     7561 tgtcgtcgtc cccgccgccc cgcacctggc gcaggccggg agaaccccag cccgctccgg
     7621 cctgcgccat caatccatcc cgtcctcaag gagacaccga tgctggcgcg cgacgaagcc
     7681 gccgctgacg aggtagcacg ccagacggtc caggaactcg agctggtcgc ccacggctgg
     7741 ttccacgtgg agtactccct ccacaggcgt gagttcatcg cctactaccg ggggcgcgac
     7801 tgccctccgg gcgggctaat cctgcgggcg gccgtccctg accagctcct cacgctgatg
     7861 gaccgtgtgg cgccgcccgg ctggcggatg ccggacctgc cggtcatgtc cgcacgacag
     7921 gcgtcgaggc tcacccgcta cggcgcgcct ggaaaccggc gtagcgggtg aggcagccaa
     7981 tgcgtacgac ccgattccag gaagaagcct atggacgtga cggcgacgtc gtatgtgtac
     8041 ggccgcgaga tcgatggcag ccacgaacgg tgggtcatct tggtggcggt ccccgtgcgc
     8101 ggtggcacgc tcctgcacga ggaacacaca cgcagcggcc ccaacaacag caggcgcatg
     8161 ctgctcaacc gcatcgtgcc gctgcccgcg ggcacgacgg tggagacgtg gttgcaggag
     8221 cgggaccaag aactgcaggc cagcggatgg gacccgccca accgcgtcgc cggcttctgc
     8281 taacacccgc atctctgctc cccctcgccg tgctccagcc agcacggcgc catcgggggg
     8341 cgatggccga ggagagagaa gggacggcgc ggctaactcc gcccagcagt ccacccacag
     8401 ccatcatcga ccagttgccc atcacaacca aagaagaggg gacccaaccg gtgaccatcg
     8461 acaacgacgt ccaagacgcc tccgcgctac gtgccgccat ggtgcgcgaa ctgcgcgagc
     8521 agggggcgat ccagtctgag cgtgtggcgg cagccatcgc caccgtgccg cgccacctgt
     8581 tcacgccggg cgagacgttg gagaccgcgt acgccgcgaa caccgcgccg atcgtcaaag
     8641 ccgacgccaa cggtatgacc ctcagctccg tttccgccgc tcacctccag gccaccatgc
     8701 tggaacaggc ggagatcgaa ccgggcatgc gcgttctgga ggttgggtcc ggcggctaca
     8761 acgccgcctt gctggccgag ctcgtcggcg aaagcggacg cgtcaccacg gtggacatcg
     8821 acccggacat cgtcgagcgc gctggcacct tcctgcgcga ggccggctac gaccacgtcc
     8881 acgtggtgct ggccgacgcg gagcagggac tcgccatgtc tgccccctac gacaggatca
     8941 tcatcacggc cgggagctgg gatatcccgc ccgcatggat cgagcagctc accgacaccg
     9001 gccggatcgt cgtcccgctc cggttcgcgg gggtgacccg ctggatcgcg ttcgaccgtg
     9061 accgctcggg tctggtcagc cgcggctacg gtttgtgttc ctttgtgccg gtccaggggg
     9121 ccggctctca caccgagcgc gccgtaagca tcgacgacgg ggtggtgctg cgcctcgacg
     9181 acgacaccct cacggtcgat acggatgcgt tgcgccgggc gttgcacctg ccgcgcatcg
     9241 cacgctggtc cgggaccgcg ttcgacatgc ccgacgaggt ggtgctgttc ctgctcacca
     9301 ccgacccgca catgacgatg ctgcacgctg accagcgacg cgtcgaccag gagctgctcg
     9361 ctccctcgac gctgcggggt gtgcccgcgc tgatcagcgg cgacagcttc gcctaccgga
     9421 ccaggcggga aaacgaccag accggcggat acgagagcgg cgtctacgcg cacggcccgg
     9481 ccgccgagca ggtcgccgcc cggtacgtgg agctgctgcg ccagtgggtc agcgagtatc
     9541 accgccgcgg tgccgcgtcc atccggtaca tcccgatgcc cgcgaacgcg ccgacccttt
     9601 ccgcaggcgt cttcgcgaag cggcacggga ccgtcgtggt cacctggcca tagaccgccg
     9661 ggggacaccc ccggggaacc caaccgcccc cacgaaggag gttcaccatg tccatgaccc
     9721 agctcaaccc gccagtcgcg gcagccttgc ccgtgccgcc gaggaatacc ggctggagcg
     9781 acgacgagtg gacggacttg gacgtgtcca tcatcgagtc cggcgtggcc gccgagcagc
     9841 tcatccgcat gaccgacgac ggctgcaact cgacgtgcgc gaccgcgtgc aacagctgcc
     9901 cgtaagcgcc ccgtgcgcct gaacagatcc gacgcctgac ccgaacgccc ggccggcgcg
     9961 gctcaccacc ggccgggcaa ccccgatgcg ggagcggcag atgtaccact acctcaacac
    10021 cgcggtgtta cgtgccccgg catggcggcc agaccagccg ccaccctcgt ggcctgatct
    10081 gaccgggtcg gacgccggcc ccacctcctg gcgggcctgg ctggctcgca cgtggcaggc
    10141 gcccggcttc gcagcggccg tcgagcaggc cagcccggat ctggcgcggc gggtgcgcac
    10201 gatcctcgat ggacggccgg tgcctgtccc ggcagtgcgc cgcgcggtcc tcgcggtgat
    10261 gcgctacctg ctgcgtgctt ccacccgccc gacaccgttc ggcctgttcg ccggcgtcgc
    10321 tccggctcgc atcagcaccg caacggacct gcctgaggtg cgcatcgggg acgcgcaccg
    10381 cccgatcgcc cgtgtcacag ccgaatggct cgccgcgatc gttcagcggc tggaaggcga
    10441 gacagcgctc cagcgacgct tgaccgtggt cgccaacaat ttcgcgttcg agcgggacgg
    10501 ccgcctggtg cttgagcacc gcgccagcac tgaggcgggc ggcgccccag gggaggtgag
    10561 cgtgcgcgcc accgcccccg tacgggaagc cctccggctg gcgcgtgacc ccctccccgt
    10621 cgcggacctg gtggcccggc tatcgggcac ctccccgcac acccccgaac gcagcatcga
    10681 ggcgctcgtg gccgaactgg tcgcccagcg cctcctgctc accagcctgc gcccgcccat
    10741 gacgacctgc gacccgctcc ggtacctgct gcacgagctg gacgccgtgg acgcggaaga
    10801 catcagcgag gtggccgaca tagtcaaggg cctgcgcggc atcgccgagg agctcacccg
    10861 gcacgaccac gcacccgcca ccgcggcggg cggtcaccgg gcgcgcgcgg ccgccgcgat
    10921 gacagccctc caccctgcga cacgcccgcc gctcacactc gatttacggc tggatgggca
    10981 cgtgatggtg ccggctgccg tggcggcgga agcagccgcg gcagcagccg cgctcgtccg
    11041 cctggcccgc cgccttgctc tgaacgcggg ctggctggcc tggcacgagc ggttcctgga
    11101 ccgctacggc ttgcgcgccc tggtcccgct gcgggacgtg gtcgacgccg acaccgggct
    11161 cggctacccg cccggttaca tcggcgcccc cggcctgggc ggcgaggtgc tgaccgatcg
    11221 cgacagcacg ctgctggccc tggcacagaa cgccgcggtg cgccgccagc gcgagatccg
    11281 gctcgatgac gacctgatcg cccagctcag cccagtggac acgcagacac tgattcagcc
    11341 gaccacggag ctgaccgtac gcatcgacgc ccccagcacg caggcgttgg ccgagggtac
    11401 gttcacgctc gccgtcaccg gggtatcgcg cacggccggc accaccaccg gccggttcct
    11461 cgacctgctc gaccccgccg accggcagcc gatgacggcc acgtacgcga agctccccac
    11521 cggcgtacgg gacgcgctcg cggtgcaagt ctcggcgcct tcgccctaca ccagtaccga
    11581 gaacgtcgcc cgcgtccccc aagtgctgcc cgacctgctg cccgtgggcc agtaccccgg
    11641 cgcccgcccg gtcgctctgg acgacgtggc cgtcaccgct gaccggcacg gaatctacct
    11701 cgtgtcgcgc tcccgccgcc gcgtcgtcga gcccgtggcc ctcaacgcgg tgaacccgcg
    11761 ccagcacacg cacccactcg tgcggttcct cctggaagcc ccgcacgctc tgcgcgcccc
    11821 gtgcgcgggc ttcgactggg gtgccgccgc ggcgctgccg ttcgttccgg cgctgcgcta
    11881 ccggcgcact atcctctcgc ccgcacggtg gcggctcacc acggccgacc tgcccgcgcc
    11941 ggcggccgta tggcaggaat gggaaagcac gctgaccaga tgggccgagc aggtcgcgct
    12001 cccgcagacg gtctccctcg gcgggggaga ccagcacctt cggctcaacc tcgccgagcc
    12061 cgcgcaccgc gccctgctgc gcgcccaagt ggaccgcgcc ggcaccgttg tgctgcgcgc
    12121 cgcacccgag cctgaggcgg ccgggtggat cggtgggggc gcccacgagc tcgtgatccc
    12181 gctcgccacg accctcccgc cagccgagcc gcccccgctc ccgcccacgg tgacccgccg
    12241 ctcccacggc cgcctgcctg gccaggacgg gcggctgtcg gtcaaggtgt acggccaccc
    12301 cgaccggcac gacgccatcc tcacccgcca cctgccgcgc ctgaccgagg cgctcggcag
    12361 cgacgcccca tggtggttcc tgcgctacca cgaccccgat caccatctcc gcatccgcct
    12421 cacagtgccc accggcgcat tcgccgctac cgccgccgag gtcgccgcgt ggagcgagca
    12481 gctgcgacgg gccaggctta ccgggcgcgt gcagtgggac acctacttcc cggagaccgc
    12541 ccgcttcggc gggcccgacg ccgaggcggc ggccgaggcg tacttcgccg ccgactcggc
    12601 cgcggccctc gcccaggtgc tcgcggtcac ctctctggga gggccccacc tgcacgccct
    12661 ggccgccgcc agcatgctcg acatcgccgc cgcgctgctc gccgaccgtg ccgcggcgat
    12721 gcggtggttg atcgaccaca cccgccccga cgcttccgcc cccgaccggg ctatctacga
    12781 gcaggccgta cgcctggccg ccccggacga ccacgccgag ctccacgcag cgcaaccggc
    12841 aggcgagcag atcatcacgt gctgggagcg gcgacggcgg acgctggccg cctaccgccg
    12901 cacgctggag gagacgggaa cgccgcccgc ggtggtgctg ccggatctgc tgcacctgca
    12961 ccacgtccgc atggccggac cctcgctgtc cagcgagcgg gcgtgcctgc acctggcccg
    13021 cgccgccgcg ttgagctgga ccaaccgccc cacaaggagc agaccatgag cgcgccacag
    13081 ccccacgcgc tggcggtagc cgggtccatc gccacggcgc tggccgaccc ccagccatgg
    13141 gtcgccgaac ctcccggcaa cggacggatc tggccgcaat ccctcgcggg cggtgcagcc
    13201 ggtatcgccc tgctgcacat cgagcgcgcc cactccggcc acggcgaccc cgccaccgcg
    13261 cacgcctggc tgcacgtggc cgcctccggc gcattgacgg cggcggccaa cgccggcctg
    13321 ttcttcggcg ctcccgcctt ggccttcgtc acgcacgcgg ccgcagacga ctcgggccga
    13381 tatcggggcg cactggcccg cctggacgac gccgtcatga ccctcacccg cacacgcctg
    13441 accgcagctc acgcccgcat cgactgcggc gaacgacccg agatgaagga attcgatctg
    13501 atccgcgggc tggccggcct gggcgcctac catttcagac gccatcccga tcacccgatc
    13561 accggcgagg tgctgtccta cctcgtccgc ctgaccgaac cgctgcccgc aggcggcgag
    13621 ctgccgccgt ggtggacgag cgtcgcaccc aacggggagc ccagctcgga ctacccgcac
    13681 ggacacggca acctgggcat gtcccacggc atctgctcgg cgctggccct cctctccctg
    13741 gccgtgatcc gcaacgccgg cgtcgccggc gtgaaagaag cgatcgaagc catctgcggc
    13801 tggaccgaca cctggcggca gcacgacgac gccggaccgt ggtggcccgg atacatcacc
    13861 cacgaccagg cgtgtaccca gcgcgtcgac ccgtcgcagc ggccccggcc gtcgtggtgc
    13921 tacgggatca gcggcacggc ccgcgcccag caactggcgg gcatggcgct cggcgaccac
    13981 acccgcaaac aggcggctga ggccgccatg ctggcgacgc tgcgcgatcc cgcgcaactc
    14041 gaccggctcc cagagatcgg cctgtgccac ggcacagccg ggctgctcca agccgcctgg
    14101 tggatggccg ccgacgccca cacctcccag atcagtgccg agctccccaa cctggcccac
    14161 cggctgaccg agcagctatc ccggagcctg cccggacccg aactcctcga cggcgccgcc
    14221 ggggccgcgc tcgccctgca caccatcggc accggcatcg cgccagcatc gcgctgggac
    14281 accttcctgc tgctggcctg accatcggag aacctgcatg gatacctgcc cgtggcggca
    14341 agtcaacctc gccttccccg actgggccag cgccgagcac atcgcggtga cccacctcgc
    14401 tccgctgctg gaagcggccg aacatgaacg gctcatcacc gcctggttct tcatgcgcaa
    14461 gaggccctgc tggcgcatcc gatacgcgcc cagcagcggc cgaacgcagc cacacttccg
    14521 ggcccacctg aacaacctca tccggcaacg ccacatcgac accgcgaccg aggccgtcta
    14581 cgagcctgaa cagcacgctt tcggcggcgc cgaagccatg tggtgctctc acgacctgtt
    14641 ccacctcgac agccggcacc ttctccacca cctcacccac tcgccaggta tgcagcgccg
    14701 ccgcgagctg tcgatcctgc tgtgcaccgt gttgctccgc gcggccgggc tggactggta
    14761 cgagcagggc gacgtgtggg cacgggtagc cgaccaccgc gatctgccca gcccgatccc
    14821 gcccgagcag cggcgcccgt tggaggccgg gctgcggcgg ctcatgagcg tggacgccgg
    14881 ccccctcctg cgcgacggcg cgccgctggg gttcgccgcc gaatgggcgg cagcgttcgc
    14941 cgctgccggg agccaactgg cccgcctggc atccagtggg ctgctgcacc gtggcctgcg
    15001 cgccgtcctc gcccaccaca tcgtcttcgc gtggaaccgg ctcggcatgc cctacaccac
    15061 ccaggccgtc ttggcccaca ccgccaagca ggtggtgttc gggcccgtcc ccgctcggca
    15121 ccatcggacc accgaggagt aaacgatcat ggacgtcgtg ctggagcagg cagctcaacg
    15181 gttccccctg atcccacgcc cccgacctgc gtgcccgccg ctgacggcgc gcgtcgccgc
    15241 gctgtgcgac ctcgccgacg cggccgcaca ccgggccgac gccgaccacc tcgcgcttgc
    15301 cgccgagacg ctgaacaagg cagcgctgat cgcgagcgac tgcggcgtcc cgggcctggc
    15361 gcgctcgctg tgctggcggc atttcaccat ctaccggctc gggtggccgc tgggcggcca
    15421 gcatgcgcgg cgggcgctgg aaccgctcgt caacctcgcc aggctggcca tccgcgccgg
    15481 caacggcttc ggcggctacc agctgatcga aaacctgctc cacgccgtca gctccggcgg
    15541 gcgggccgac atcgacgggc gcccggtgtc gttcgactcc ttcacccgca ccagcgacga
    15601 cctgcggatg gtccgccagt ggctgtacgg ggtgttcgtc gccgaaggca tccgggcgct
    15661 gatcagctcc agccgctggc aggacgccgt cacccatgcg cagcagtacc gaggcgtcgg
    15721 cgagcgactc ttggacggac ggcaggccgc cgtcgtcgcg cactgcctgg ccgggcacgc
    15781 cgacaccgcc gcggcgctcc tcgccggcag caccctcgtt cagccgtggg agcacgcggt
    15841 ggccgactgc ctggccatgc tgtgcgaccg ctccgccgga cactcgacca gcaacatcgg
    15901 cgccgaccta caacgccact acctcgaact cgaccgcaca ccagaactgg tggtgttccg
    15961 tacccgtctc ggcctgacca tcctcgacct cgccgacgcc gaccggcccc tgaccggcca
    16021 agtgttcgcc tgcctgatca gcgacctaat cgcgacggcg gacgggtacg ccgcccgaga
    16081 cgccctgtcc caccaaggat gcagaaccag actgacgacc cgccagcagc gggcactcgc
    16141 ctcagctgtg gagtccgccg ggctgagggc cgaggcgatc ccgcagccgc tggtgcgtta
    16201 cctccacacc gcagtggaga tcggcgaggc tgtgctcgcc cggtctctcg acgcggccgc
    16261 tgtcgaggcg actgctcctg cctcgacggt ccgctcatag cggcgatacg gccagtagag
    16321 agcctgccgc cacctgcagg ggcagcggtc accggctttg tgcgctcgcg gtagcagtag
    16381 ccataaccgc gttctgcacc tggcgcaggc gcttggtctg gtcatcggcc gccatcaggc
    16441 gccgtcggta agcggcgacg acctccgact caccgagcca caccttgtcg cctccgtgcc
    16501 gacgcggcca acgcagcggg ctgtccttcg caccggggag cgagacggcg tgtggagcct
    16561 gcgggcttgg tggtaccgag atgagcagga agcccttgcc cgggacggaa gggttggcta
    16621 cctccgcatc tcgaatcgag gcatcgggat gccccgtgtg gccgccgcgt tacgcacccg
    16681 actctgcagc ttgatgaagg acacgttcaa cggcttggac gggatgtctc cgacctcggc
    16741 cacgccgacg acgatcagtc aaccgatgtg gttggcgaag gtggcgacgt cgacggtggt
    16801 gtcctcgttg cccttctccc cggaggggat gtcgcacttg tagttcaggt cttcggttcg
    16861 cgggcatcgg gattgttgac cacagcggcg atctgggcat agctgagcag cgtgtagcga
    16921 acgcaatgcc cgggccagct acatcccgtg gcacgggctc tcggcagcgc ccatccggtc
    16981 ttacgggtga gcactgttct attttggcat ttcagcccac gtggagcggt tcgggacggt
    17041 cggccgtggt ggcgatcaaa tggttgtgga ggaacgcgct gatggcctcg tacgcggtca
    17101 gctcgttggc gcggttggtg aagccgtggc cttcgtcggg atagatgtcg tagcgaacct
    17161 cgacgccgcg ttcgcgtagc cgggcgacga tctggtcgga ttcggcctgg ggaacgcgtg
    17221 ggtcgtgggc tccctggagt acgaacaggg gcgcggtgat gccgtcggcg taggtgacgg
    17281 ggctgcgctc caggagctgt tcggcgcggg tgtcgggatc cccgaggaca gtggcgacga
    17341 aggtcttcca ggtggggggc gacgccttcg ccagtgtgag gaggttgctg gggccgcata
    17401 tggagacgcc tgcggcccag gggtagggga ggcgggccag gcaggacaga gcggcgaagc
    17461 ctccgtagga agcccccatg acggcgagtc ggttcgggtc ggtccagtcg agggcgtgga
    17521 ggtatttgac ggcgtggtcc aggtcgtcga ggtcgatgcc gccccagtcg cagtagatga
    17581 gtttctggtg ggcggtgccg tacccggtgg atccggcgaa gttgggggcc aggatggcga
    17641 tgccctgatg gagaagatgc tggtagaggc cggagcgggc gtagaggggg cgttcctggg
    17701 attccgggcc gccgtggatg gacagcagga ccgggtgcgg gccggggccg tccgggcggt
    17761 agagcagagc gtggacgtcg cgtccgtcgc gggccgggta ggtgatcagc tcgggggcga
    17821 cggggtcgat gacatgcagc gccggggggc gggtgtcggt gaggtagcgg aactcgtggc
    17881 gggctagatc aagcaccgct atttccgccg gcctcgccgc ggagttgatc aggaggaccg
    17941 cgaaggaagc gtcaggcgcc agggacagcg cggagatgac gccgggcggg atgccgggca
    18001 gcgagacagg ggagccgtcg cggtcggcgt gcaggaggga gctgccgccc tcgttgacgg
    18061 accagatgcg gactcccgca gcggcgtcga ggacctcgac gtcccacttc gggcgcgcga
    18121 tcgcctgcag ggagctggct gcgaggtcgt agaaggcggc ggcggtgaac tcgctccagt
    18181 ggtcggtgag caggtggaag ccgctggagt ccgccgccca gactccgggt tcgaagacac
    18241 cctcgcccag gtcggatgtc aggcagaccg gctcggcgtc tgggtcgctc aggttgatga
    18301 ggtagatggc gatgtcggtg ttggagcgga acccggttgc cagtagccag cggccgtcgg
    18361 gggagaggct ggcggcctcg aacgcaaccc cttgcgaggg cgtgaagcgg cggagctcac
    18421 tggtctgcag atcgtggacg atgaggtcct gagcggcggg gtcgcggtcg ttggcggtgt
    18481 aggccaggaa gcggccggtc gggtcgaacg gggatgtggc caggacgcgc tggcagtccg
    18541 gcccggagct gatctcggtc aggtcgctgc cgtcgagagc gacgaggtag aggcggaatt
    18601 gctcgtcgcc gttttcgtcg gcggtgaaga ccagccgatc gccggagggt gtccaggcga
    18661 tctggcggac agctcggtcg tcgaagcccg ccacgcggcg cggctcgcca ccggtgacgg
    18721 gaacgaccca caggtcgtag tgtccggagg cgtggctgga gtaggcgacc aggtggccgt
    18781 ctggggacag tgcgagggtg ggctggaatc gctgctgggg gacaaagtcc aggtatccgg
    18841 gcatgtgaca gggcctctcg ggttcagtcg atccagccgc ggcgtactgc tgcggctccg
    18901 gcggcgaagc gggtctccac gcccagctca tcgcggatgg cggtccagtg tcggcgcatg
    18961 gtgttgacgc tgatgtccat ccgccgggcg atcgcctcgt cgggtagtcc ttggttgagc
    19021 agctggagta cctgcaactg cgcgggtgtg agcggcgcgg cggccttcgc gctgccgaac
    19081 gggatcgcct tctcccagag cagctcgaag tactcccgca gcgcaccaac gatgacgggc
    19141 gagcgtacga gcagtgcccc gcccatgcct gtcggtgtca ggggaagaag cgcgaccgcc
    19201 tcgtctgcga gcttcatctt cattccgatg cggggcagta gccgcgcctg ttcgccggct
    19261 tcgaccgcgg cctcgatggt cttcgcaccg atcgggtgct ctgcgcagcg ggtctcgtag
    19321 atcgcccggc attgcacccg gccctcgaag actggcagcg gtgcgtaccc ggtggagtcc
    19381 tcgacgggcg cctccaggac gtagttgtcg agcgtgagcc agtcgtgtcg cgcggcgttg
    19441 atgagtgcgt aggacaggga actgatctcg tcccggtcgg tgacgatctg cacgagccgg
    19501 tccatcgcgg agttcgagga cgccgcggcc ggcgtctggt ggaactcgct cagccgcttg
    19561 tgtccagcca gcaaccgctc ctgatcgttg accaggcggc gtgaaagatc cgtcaagacg
    19621 ccctgcagcg cgagttctgg gggagcgggc acgagacgcg gcggcatcgc ggggccgtcc
    19681 ggacggcgat gtgccatccc gcgggccgtc agttccgcga cctgctcact gcttcccagc
    19741 agggacgcgg cgtcgtcctc agggcagccg ccctccgtga gcagcatgga gtacgacacg
    19801 aagatctctt ccgggacgac gccctccaat aggcgcttcg ctttgacctg atcctgtccg
    19861 tccaccgtca cctccgatca gagagtagtg gccatgacac gcattgtgat ggcccatctg
    19921 gccgtgtcgg acgatgagtg gttccgagcg atggtgagtt ttcaccatcg agcgctttgc
    19981 cccagaagcc cactgccata ggcgttctcg ccaccccgga caccgcgccc acggccagta
    20041 gctgccgtgg agagtttcac cacctctgtt gcggtgccgc gcccggtctg atcagtgcga
    20101 aagctcaaga gtggcaaggg gaggcagcat gcggcagctc gtcgaagacg tggtgaggaa
    20161 gctgagtgca gcggttgcgg cgtcgatggt gttgggcgcc agttcgccag ccggtgcgtt
    20221 ggccaacgcg gaaccttact gtccgcaggt gggccgagcg ccacgacagg tgtacgacat
    20281 cgagaagttc tgtgagttgg tgtatggcga cctgatggaa ggccgggcac cgaacctcct
    20341 ggagttgctg gcacggtcgc agcgcattcc ggtgcatacc tcgctcgctt ccaagtcgca
    20401 gaaggtgtcg aagtcacatg atgtgaggtc gacggtgaag cggcctgaag ctgagcccgc
    20461 tcgttttcgt aggagtgatt tcgaaccacg catgccgggt gaaggcggca gggaagccgg
    20521 ccgggctccg ggtcgagctc tgaaccgaga ccgtcgagca agcgtcgacc gtcagaagcg
    20581 ttcgcggagg aacggtagga agccatcgtc cacgacggtt cccacgccac cggctgctcc
    20641 atccgaaacg ccgtcggcat cggcttctac atctttccct gtgcctgcag cggtttcctc
    20701 tgcgcctgcg cctgcgcctg cgcctgcgtc gcgcgatgcg gtgaggccga agtcagagca
    20761 tctgtctgag gcgatgggtc cgctgggtgc cgcgctggcg ttcgggctca tgctcatggt
    20821 cctgagcgct gcgcttatcg gtcgtctacg gtcctggccg gcgcaggcga gcgcggactc
    20881 gtctgccgtg gccctgtctg gcggtatcga tggtcgcaac ggtgaggaag ctgaactacg
    20941 cccggcggtt gtcctggcat ccgctggggc gcaggcgcct gtggtcgact gcgtgacggc
    21001 ggaggcggtt gccgagcctg accgtcgtga gcatctggcg gtgaccacgt ctcagcctga
    21061 ccagcccagc tttcgcccgg cggtcgcaaa ggtaggtgcg gaagcggaga ctgaggagcc
    21121 gttcgtgcaa ggcgcttcag tcgacctggg atcggggttc cttgcggcgg ccggcaaggc
    21181 gaaggtcgag gtactagggg taccgcggct gtcgtatggc aggtcggata tctccttcgg
    21241 acgtgccgag gctcgcgagt tgtttgcgtt gctttcggtg tcacgggacg gcgtttcggc
    21301 ggaggggatc gccgagacgc tgtggccggg ggaggtcggc gggcgccggt tggattcggc
    21361 ggtacgggag atcaaccggg ctatgcggca ggcggtgggg tgtagggccg gcgtgcggtt
    21421 cgtgctgaag tccggggagc ggcgactgct gccggcggca tcgtttgatg cggacttctg
    21481 gcggttcgag gacgcgtgca agctggcctc gatcgcggcc gaggatgctg tgcggatggc
    21541 ggcgttgcat gaggtgctgg ccttgtatcg aggggcgcta ctggctgggt gtgatgacct
    21601 gtgggtgctc ccgctgcggc aggccgctca gcggcaggca gcggatgccg ctgagcggct
    21661 ggccgagttg gtgcgagccg atgatccagg ccgggcggtg gacgtgcttc ggttggcggt
    21721 cgagcgcatc gatccgtgca gcgagacgtt gtggtgcctg ctgatgtcgg tccaaggcga
    21781 gcttgggcgc ctgcccgcgg tgcggcgttc gttcgagttg ttgagggaac ggctgtcgga
    21841 gatcgacgca gtgccgagta cgcaggcgcg gcaggtgtat gagcggttca tgcgctgacc
    21901 ggccccgtcg aacagcggag gatgctgggg acctggcggt gccccggtcg gggctcaccc
    21961 ttcttcgtga agaatgcgtt ggtcgtgccg tgcgtaggtg gccagcgtct cggccgtgag
    22021 cagatgggcg gggcgggtgc cgtagatgcg ggccagcaag cggagcgtgg agacggaggg
    22081 acgtcggcct gcttgtggcc agttctcgta gtcgtagagg cgagactcgc gcaatccggc
    22141 accgatagtg ccggcgaact ggtggaacgc ctcgatcgtc tgcgccgcgg tgagtccggc
    22201 ggcataccgg tagaggcgga gcggggtggc cgggtggtcg aggccgagga tgacggcgat
    22261 ctggtcgacg gtgaagccgt gctggcgtag gtaacggctg cgtcggcggc agtcgagaag
    22321 tgttcggtat ccggtacctg acatgcgttg atgccccctt tccagcccac acgtggtggg
    22381 cgcgtcggtg ccccgcatcc ggggtcgggg ggacggtagg gggacttggt ggagaggctc
    22441 aagctgctga ccggggtggt cgatacgttg atcgtcaggt gatcacatgc ccgggacagc
    22501 gcgttttcgc aggtcgtgac agcgatcggg cccgggcatg gacccgtgat tgttgggggt
    22561 gtgattcgga cacagaggtg tccgatggtg ctggtcgctc cggatgggcc ggggttcacg
    22621 gaggtgacca gcggtgaatc agcatcggga ccagcagcca cagagttggg caactcgggc
    22681 cgccgattcg tcttgcgacg ttctctcgag tgggggagaa aagttgcgga gcgagttccc
    22741 gaattctcag ccggatgacg tgctggctga gctccgcagt acccagtacg agggtatgtg
    22801 gtggcgacgg gcgttcgcag gccaggggga ccaggccgct ccggcccgtc tcctcgtcgc
    22861 gctgctgctg ggggacacct gctgggggca ggatgcggag tgggtggccg cggaactgat
    22921 cagcaatgct ctgcggcaca ctgactccgg cgtcgcgggc gggttcttcg tggtggaggt
    22981 tgcgcgtact ccacgtaagg cgcgcttggt cgtgcacgac ctaggtggaa gcggcacgcc
    23041 ggacttcggc cgggcggtca aactggctga acagcgcaag ccgggccagt acgaggacgg
    23101 gtacggcctg gcaagcgtgg cccgggtggc gagccgggtc ggtgtgtcgg gagacccgat
    23161 cggggggcac gcggtctggg cagagttcga cttgattgcg tccggcgacg aggagcacca
    23221 gcgccgaggc gaaggtgatc ggaaccggga aggtgcggct ccacccgatt acgagccgac
    23281 cgcgctccgc cagtcagctc tcgccttgac ggcctgtcaa cggccatgag gatccccagg
    23341 taggtggact tgggttctct cagctggtgg ccatcagaaa tccatgctga tggccggggt
    23401 ggtcctgatg ggtggtcagg tcaacggggt gacgcccttg cccgccagag cctcggcgag
    23461 ccggtgggaa tcgcccttgg tcaggaccag gtgggcgtgg tggaggagcc ggtcgaccga
    23521 ggcggtggcc agggtcttgg gcatgatggt gtcgaacccg ctcgggtgaa tgttgctggt
    23581 gatcgcgatc gagcggcgtt cgtaggcggc atcgatgatc cgatagaacg cctcggcggc
    23641 gtcggttccg gccgggagca gcccgatgtc gtcgatgacg atgaggtcgg cgcggcagat
    23701 ccgggcgacg gtgcgcgcga tggagccgtc gactttagcc ttgccgatcg tggtggtgag
    23761 ggtttccagg gtgaaccagg ccacgcgtag gtccttctcg atggccgcgt gggccaggcc
    23821 ctcggtgaag tgcgatttgc cggtgcccga agggccggcg atcaccaggt tttcggcccg
    23881 gccgatccat tccagcgtgg ccagggcgtt ctgggtgggt tcggggatgg aggactcctc
    23941 cggtcgccag gacgcgaggg tcttgccggt ggggaagttg gccgaggtgc ggcgcagccg
    24001 ccgggtggcc gcgtcgcggc cggtgacctc ctcgtggatg agaatgcgca ggacttcggc
    24061 ggggtcccag cgttgcgcgc gggcggtggc cagcacgtcg ggggcggctt tgcgcaggta
    24121 gggcaggcgc atccggcgca gcagccggtc cagttcgtcg ggcagagccg gtggggtggg
    24181 cgaggtcatg ggtggggttc tcctcatcgc gggcacccgc ccggccgcgc aggccgggca
    24241 ggtggtgggg tggtcactgg cccagggcct gccaggatgc ggtgccgggc tgagccgaat
    24301 gcctctcatc ggcgcgcacg agttcgccga cggcccggtg gtcgctcaga tggtcgacga
    24361 tggcgggcag gtcgtcgtcg gcgaagcggc cggcgatcgc ggcaaggccg agtgcctcgt
    24421 cgacgcgttc agcgccgagc actgcggcca gttcgacggc gcgggccatt ttggcgcgga
    24481 tgcgcgcggc tccggcgggt ccggcctcgg tcagccaccg cttggcgccc ggtccgatgc
    24541 ccaggaaggc gacctccgcc tcgttgcgcg gccgtggttt cggctggtgg atgctgcgcc
    24601 cattgggatg gtgcgggtag tgctcggcca ggatctgtgg gttacccggg acagacactc
    24661 gatggcgggc gatctcggcg agctccccgc cggcggcccg ggcggtgatg acgagttcct
    24721 cgccgaccac gcgcacccag accttggtgt cgacgtgtcc gggtggggtg gagtagcgca
    24781 ccgaggcgaa gctgatggtc tggtcgtcat agacgatccg ctgctcaccc agcgccagcg
    24841 cgaacggctc ggcgggcagc acgtgcagcg tctgctgctc gattaacagc tgctcggcgg
    24901 ggatctggcc gctgccgcga tgccggcggg cgttgatctt ctcgcaccag gtccggcatt
    24961 gttcggccaa ctctgcgaaa ccgccgtact ggctgcggag gttggcctcg gtgggtacca
    25021 ggtcggcctt ggcgagccgg acggtggcct ccacgccgcc cttggattcg ggatcgtaag
    25081 gcacgcaggt ctccacggtg cagccgtagt atcggcccgc ggcgaggatc tgcggatgcc
    25141 gc
//
