LOCUS       NZ_CP045608            21629 bp    DNA     circular CON 16-FEB-2024
DEFINITION  Bacillus cereus strain SB1 plasmid p2, complete sequence.
ACCESSION   NZ_CP045608
VERSION     NZ_CP045608.2
KEYWORDS    RefSeq.
SOURCE      Bacillus cereus
  ORGANISM  Bacillus cereus
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus;
            Bacillus cereus group.
REFERENCE   1  (bases 1 to 280820)
  AUTHORS   Batinovic,S. and Petrovski,S.
  TITLE     Bacillus cereus SB1 complete genome
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 280820)
  AUTHORS   Batinovic,S. and Petrovski,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (05-NOV-2019) Department of Physiology, Anatomy &
            Microbiology, La Trobe University, Kingsbury Drive, Bundoora,
            Victoria 3086, Australia
  REMARK    Sequence update by submitter
REFERENCE   3  (bases 1 to 280820)
  AUTHORS   Batinovic,S. and Petrovski,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (25-OCT-2019) Department of Physiology, Anatomy &
            Microbiology, La Trobe University, Kingsbury Drive, Bundoora,
            Victoria 3086, Australia
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: NOV-2019
            Assembly Method                   :: Unicycler v. 0.4.8
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 46x
            Sequencing Technology :: Illumina MiSeq; Oxford Nanopore MiniION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/16/2024 03:34:28
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,375
            CDSs (total)                      :: 6,221
            Genes (coding)                    :: 5,991
            CDSs (with protein)               :: 5,991
            Genes (RNA)                       :: 154
            rRNAs                             :: 14, 14, 14 (5S, 16S, 23S)
            complete rRNAs                    :: 14, 14, 14 (5S, 16S, 23S)
            tRNAs                             :: 107
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 230
            CDSs (without protein)            :: 230
            Pseudo Genes (ambiguous residues) :: 0 of 230
            Pseudo Genes (frameshifted)       :: 89 of 230
            Pseudo Genes (incomplete)         :: 140 of 230
            Pseudo Genes (internal stop)      :: 70 of 230
            Pseudo Genes (multiple problems)  :: 57 of 230
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 10:27:55
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 218280
            Orig. end                         :: 239909
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP045608.2.
            On Dec 19, 2019 this sequence version replaced NZ_CP045608.1.
            Bacteria and source DNA available from Steve Petrovski, La Trobe
            University, Bundoora, 3086, VIC, Australia.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21629
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ranthipeptide"
                     /region_number="2"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     cand_cluster    1..21629
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21629
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11629](+)"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11629
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
     misc_feature    complement(671..686)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: strong, score: 19.26"
                     /tool="antismash"
     misc_feature    complement(865..880)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: strong, score: 19.26"
                     /tool="antismash"
     misc_feature    complement(946..961)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: strong, score: 19.26"
                     /tool="antismash"
     gene            1129..2241
                     /gene="ald"
                     /locus_tag="GE376_RS30915"
                     /old_locus_tag="GE376_30930"
     CDS             1129..2241
                     /EC_number="1.4.1.1"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0000286 - alanine dehydrogenase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006522 - alanine metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ald"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002205049.1"
                     /locus_tag="GE376_RS30915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GE376_30930"
                     /product="alanine dehydrogenase"
                     /protein_id="WP_153218577.1"
                     /transl_table=11
                     /translation="MKIGVVKEIKKGEARVGMTPENVQKLVSAGNEVLVQKDAGLGSGY
                     TNVEYINAGASIVNQGQAWDVDMVVKVKEPLPAEYHYFKKDLIVWGFLHLAASKECVEA
                     MKKAGTTAIAGETISEDGNLALLKPMSAIAGRRAVFMGAYYLEKQHQGEGILLSGIEGI
                     PAGKVVILGGGNAATNACDMAIGIGCSVTILEVNQERIAYLRKQYATEEVNIIESNTEN
                     LERTIKEADLFISTILIPGSRPPKIVKEYMVQSMKPGSVIVDIAIDQGGTVETIDHYTT
                     HDNPVFIKHDVIHYAVPNMPGATPRTSTMALANGNIEYLLAISKDGLENAIQNKSSLAS
                     GVNVYKGIITYENLGMTLGLDFKQLKEVLV"
     gene            2238..3239
                     /gene="tdcB"
                     /locus_tag="GE376_RS30920"
                     /old_locus_tag="GE376_30935"
     CDS             2238..3239
                     /GO_function="GO:0004794 - L-threonine ammonia-lyase
                     activity [Evidence IEA]"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0006567 - threonine catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="tdcB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PALP"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1081: cysteine synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002147986.1"
                     /locus_tag="GE376_RS30920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GE376_30935"
                     /product="bifunctional threonine ammonia-lyase/L-serine
                     ammonia-lyase TdcB"
                     /protein_id="WP_153218578.1"
                     /sec_met_domain="PALP (E-value: 7.6e-86, bitscore: 282.0,
                     seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MITKNVLLDITNIKKAKEILDVNARKTPLVKSFYLTSKTGGEIYL
                     KLENMQLTGSFKFRGAFNKISQLTNEEKERGVIACSAGNHAQGVALSSHLLGIKSKIVM
                     PTSAPQAKVDATRGYGSEVILYGDTFDDAKAKCEEIIKETGETYLHPYDDVEVMAGQGT
                     IGLDILDDMWDVDTVIVPIGGGGIISGIAVALKSFNPSINIIGVQAENVHGMKASYDAG
                     RILEHYEAPTIADGCAVKIPGNLTFEIVKDLVDDIVTVSEEELEVAMKDLLQRGKAVVE
                     GAGALATAALLAGKVDKYVQGKKVVAVISGGNVDLKRISSVCEHFFVANEVK"
     gene            3334..4716
                     /locus_tag="GE376_RS30925"
                     /old_locus_tag="GE376_30940"
     CDS             3334..4716
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1038: phenylalanine-specific permease"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001284904.1"
                     /locus_tag="GE376_RS30925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GE376_30940"
                     /product="amino acid permease"
                     /protein_id="WP_153218579.1"
                     /transl_table=11
                     /translation="MANLFRKKSVRKLLEDSKSKTLTKTLGAFDLTMLGIGAIIGTGVL
                     VLTGLVAARDAGPAVIFSFMIAAIVCGFAALCYAEIASALPVSGSVYTYSYATIGEFVA
                     YLMGWTLLSVYIVTTAAVAGGWTGYFHNLLNGFGIEIPRSLLTIPTQGGIVNLPAVIIT
                     LVLTWLLSKGTKESKRVNNAMVLIKIGIVVLFISVGIFYVKPENWIPFAPYGISGIFAG
                     GAAVFFAFLGFDALATSAEEVKNPQRDLPIGIIASLVICTIIYVIVCLVMTGMVSYKEL
                     DVPEAMAYVLEVVGQDKVAGIIAVGAVIGIMAVIFAYIYATTRVFFAMSRDGLLPKSFA
                     KINKKTEAPVFSTWLTGIGSALIAGFIDLKELSNLANIGALLTFAMVGVSVIILRKTHP
                     NLKRGFMVPLVPILPIISITSCLFLMVNLPLKTWVYFGIWLFIGIMVYFMYSKRHSQLN
                     KL"
     misc_feature    complement(4799..4812)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: strong, score: 24.03"
                     /tool="antismash"
     gene            5179..6204
                     /locus_tag="GE376_RS30930"
                     /old_locus_tag="GE376_30945"
     CDS             5179..6204
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1066: alpha/beta hydrolase domain-containing protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001220680.1"
                     /locus_tag="GE376_RS30930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GE376_30945"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_153218580.1"
                     /transl_table=11
                     /translation="MKINQSNLKGVWKKRILIFLLIVFGLIIAGVSYWNLSPTPKAFLI
                     KKAFEGGMFVQSDNYQNALKETQIVKDINYNSKFPDGMLDIIYPKNHTDNTPVIFWVHG
                     GGFVGGDKSDITGYAVELAAKGYAVININYALAPKMKYPTPVFQLGEAYEYIKENAKKY
                     NLKLEQVYFAGDSAGAQISGQFVNIQTSANYARLTKIDPVVEPATIKGTLLFCGPYNMP
                     ALAKMETTKEVQDFMRTTGWAYFGKKDFETLPEIEIASIIKHVTKDYPPTFITDGNTAS
                     FEDQAKALASELESKGVPIEKLFFDKNISGELAHEFQFKMNTPAGRETFNKVLEFLNEN
                     K"
     gene            6763..9378
                     /locus_tag="GE376_RS30935"
                     /old_locus_tag="GE376_30950"
     CDS             6763..9378
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000527246.1"
                     /locus_tag="GE376_RS30935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GE376_30950"
                     /product="putative mucin/carbohydrate-binding
                     domain-containing protein"
                     /protein_id="WP_153218581.1"
                     /transl_table=11
                     /translation="MGNKSKYKTKRILVATATLTIIASGMASSSDVFAEETQQQKSLST
                     SLQSEKSVKSENRTFTVPGKGDVEVLKQQERKSMAFSPYEPTGLYAKPNEQITINVEGN
                     QDIQVYIGTYSYDASWREDSKIKSFTLKPGVNTIQSPNGGLIYFYNKQQGGSIRTTITT
                     GGTTTPFFELGKHTKQDLINMLDQYPNAHAVELKGERVLITASPARVKKYLLGSNTDPV
                     QLLKKMDEATRIQDKVAGLSEEQVDKHYIHYVEENHSPDYYMYAYPYRTAYVGDAIQYV
                     LDINKFTTDGWGPWHEAGHLRQQIPWRFYNMGEVQNNIYSLAVEKAFNQPSNLEKSGTY
                     TKAFQYLEQTNKNYDEISDVFVKLVMLWQLQLAYGEDFYPKLHQLYRDMPSNEIPQTDE
                     TKKQLFMISASKAAKQNLIPFFEKWGLRPNNDTIQKVAALGYPILTAEIWKSTDSNPIK
                     PDMPNENNILEGNQFAWSLKGIGDFEFAKINFNKSTEEMQVDLKAGVPHHYFNETYASI
                     KVQNASGKVVYNKDIYGNKQQNAESQKVSVKVGDYIELTHLEGVHRATLTNVDNSKQES
                     FGKKAIYEVTKEGLKKVEKMPEATILDGNQFAWSLKGYSDREIAKVNYDKTVEEMKVKL
                     EAGVPHSYFTSTYASIKVQNASGNVLYNKEIVGNKQQNAESQTVPVKIGDYIELTHIEG
                     EATKEKTRATLINLENNKNETIGKTARYQVTKEGLKKVEKMPETTVLDGNQFNWSLKGY
                     NDREIAKVEYNKATEKMQIKLEAGIPHSYFTSTYASIKVQNSSGNILYNKEIVGNRQQN
                     AESQTVPVKVGDYIEFTHIEGEAQKEKTRATLTNLENSKQEFVGKKKTYQVTPTGLLIK
                     "
     misc_feature    9558..9573
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.55"
                     /tool="antismash"
     misc_feature    9716..9726
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.94"
                     /tool="antismash"
     misc_feature    complement(9726..9742)
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: weak, score: 20.48"
                     /tool="antismash"
     misc_feature    complement(9936..9951)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: strong, score: 19.26"
                     /tool="antismash"
     misc_feature    complement(9937..9952)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 22.54"
                     /tool="antismash"
     gene            10001..10162
                     /gene="scfA"
                     /locus_tag="GE376_RS30940"
                     /old_locus_tag="GE376_30955"
     CDS             10001..10162
                     /codon_start=1
                     /gene="scfA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: SCIFF"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR03973"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016113838.1"
                     /locus_tag="GE376_RS30940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GE376_30955"
                     /product="six-cysteine ranthipeptide SCIFF"
                     /protein_id="WP_000821353.1"
                     /sec_met_domain="TIGR03973 (E-value: 2.7e-22, bitscore:
                     72.4, seeds: 29, tool: rule-based-clusters)"
                     /sec_met_domain="SCIFF (E-value: 2.6e-22, bitscore: 72.5,
                     seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRIITLSTCKLQDTIKHGGCGACQTSCQSACKTSCGVANQKCEN
                     TINRKQEV"
     aSDomain        10223..10534
                     /aSDomain="Ranthipeptide_rSAM_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing rSAM protein in a
                     ranthipeptide/SCIFF cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_GE376_RS30945_Ranthipeptide_rSAM_RRE.
                     1"
                     /evalue="4.30E-34"
                     /identifier="RREFam024.1"
                     /label="GE376_RS30945"
                     /locus_tag="GE376_RS30945"
                     /protein_end="104"
                     /protein_start="0"
                     /score="107.7"
                     /tool="antismash"
                     /translation="MIHQYKLNGYNIVLDTYSGSVHVVDDLAYEIIMLYQNTPMEEILS
                     IMQEKYKYDFHVSKKEIRETIADIEELKRDGKLFTEDDYRDLSIDLINRPTYVKALCLN
                     "
     gene            10223..11629
                     /gene="scfB"
                     /locus_tag="GE376_RS30945"
                     /old_locus_tag="GE376_30960"
     CDS             10223..11629
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /GO_process="GO:0031179 - peptide modification [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="scfB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: SPASM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Ranthipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016513581.1"
                     /locus_tag="GE376_RS30945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GE376_30960"
                     /product="thioether cross-link-forming SCIFF peptide
                     maturase"
                     /protein_id="WP_153218582.1"
                     /sec_met_domain="Ranthipeptide_rSAM_RRE (E-value: 3.7e-33,
                     bitscore: 107.7, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="PTHR43273 (E-value: 2.5e-75, bitscore:
                     247.7, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 2.5e-12, bitscore: 41.4,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 1.4e-14, bitscore: 48.5,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 4.6e-20, bitscore:
                     65.8, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 3.1e-06, bitscore: 21.6,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIHQYKLNGYNIVLDTYSGSVHVVDDLAYEIIMLYQNTPMEEILS
                     IMQEKYKYDFHVSKKEIRETIADIEELKRDGKLFTEDDYRDLSIDLINRPTYVKALCLN
                     VAHTCNLSCEYCFASQGKYNGNRAIMSFEVGKRAIDFLLENSGNHRNLDVDFFGGEPLM
                     AWKTVKQIVAYARNKEKEYKKTFRFTFTTNGMLLNDEITEFLNQEMHNVVLSLDGRKKV
                     HDYLRKTVNGKGSYNHIVPKFQEFVEKRGDKEYYVRGTYTHNNVDFTNDIYHIADLGFN
                     KISMEPVICNPQEPYALCEEDLLEIYNQYEILSKEMLNREEKGNGFTFYHYMLDLSEGP
                     CVQKRISGCGSGTEYLAITPWGEIFPCHQFVGEEEYSMGNIWDGIIRAEIQSQFKESNC
                     YSKPECQECWAQLYCSGGCPANTIHATGSLKGTHEFSCKIFRKRIECSMMVKVAQSIRA
                     MKKEEQGMVQ"
     gene            complement(11774..12169)
                     /locus_tag="GE376_RS30950"
                     /old_locus_tag="GE376_30965"
     CDS             complement(11774..12169)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016119385.1"
                     /locus_tag="GE376_RS30950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GE376_30965"
                     /product="DUF3221 domain-containing protein"
                     /protein_id="WP_153218583.1"
                     /transl_table=11
                     /translation="MFSKKQKLVTVVTTLTLGCGLVFGLTPTSADSISNSTPIKEEQVR
                     IQIPFTGYVISADDNYLVVADTNTKEEALSYQNNWWELASQNKILRVPITSKDNYSVGE
                     KLNIFSVGWTHSIPPIAVMPVIEKIIE"
     gene            12483..13388
                     /locus_tag="GE376_RS30955"
                     /old_locus_tag="GE376_30970"
     CDS             12483..13388
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016083486.1"
                     /locus_tag="GE376_RS30955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GE376_30970"
                     /product="Rpn family recombination-promoting
                     nuclease/putative transposase"
                     /protein_id="WP_000167466.1"
                     /transl_table=11
                     /translation="MTKSLVNLRIDFAFKQLFGTSGSEDILITFLNAMLKNSLESPIMS
                     LQLEDPHLHREHEDDKLSILDVSATLDTGTKVNVEIQLNNNHDMIKRSLYYWGKLYTSQ
                     LQKGMPYSSLSKTITINLLNFVLFPEYEEFHTTGKLWNVQQQKQFSDDIEIHVIELPKL
                     MEQWREEKVNPWEDSFVRWLLLLPANEDEHLTQTLEDIAMNQDPILQKAMNKWERMSQD
                     STFRQAYEAREKTLMDEAAKFAHAEEQGIKKGIEKGIEEGKKAERIQLVCGMYKNGMSV
                     EDIAKFTKLPIEEIREIIQL"
     gene            complement(13533..14507)
                     /locus_tag="GE376_RS30960"
                     /old_locus_tag="GE376_30975"
     CDS             complement(13533..14507)
                     /EC_number="1.13.12.-"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016703 - oxidoreductase activity, acting
                     on single donors with incorporation of molecular oxygen,
                     incorporation of one atom of oxygen (internal
                     monooxygenases or internal mixed function oxidases)
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016119387.1"
                     /locus_tag="GE376_RS30960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GE376_30975"
                     /product="nitronate monooxygenase"
                     /protein_id="WP_029443194.1"
                     /transl_table=11
                     /translation="MKWGIYLNFPQLKIGHMMPKVPILQGGMGVGISLSKLASAVANAG
                     GIGIISGTGISIDEMRMHIRKAKEKIRNTGYIGVNVLFAMNDFAEKMKAAIEEKVDFII
                     SGAGISRDMYTWGKNAGIPVISIVSSAKLARLSERLGAAAVVVEGHEAGGHLGTDRPLF
                     DILPEVVAAVKIPVIAAGGIMTGKDIARALKMGASGVQMGTRFVASNECDAPLSFKEKY
                     INARLEDTILVKTTVGLQGRAVKNNFTKLIADNNKKIKIKKCINCLKNCSYRFCTLDSL
                     ITSMDGDCENGLVFAGARVNEVKEILPVQTIINNIMMEYRACI"
     misc_feature    14603..14612
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 18.57"
                     /tool="antismash"
     gene            complement(14950..15180)
                     /locus_tag="GE376_RS30965"
                     /old_locus_tag="GE376_30980"
     CDS             complement(14950..15180)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016083488.1"
                     /locus_tag="GE376_RS30965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GE376_30980"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_000467338.1"
                     /transl_table=11
                     /translation="MFGLGKKRTSFGEYLDHRGIKQQWLVQRTGLSKSLISDLANKKDR
                     IPTLTSATKIIRILKKFDKHIDYQDFWNIDI"
     gene            complement(16003..17481)
                     /locus_tag="GE376_RS30970"
                     /old_locus_tag="GE376_30985"
     CDS             complement(16003..17481)
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="resistance (resist) vanS"
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002150944.1"
                     /locus_tag="GE376_RS30970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GE376_30985"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_153218706.1"
                     /transl_table=11
                     /translation="MKMKRITYKLFMTTSLILLAFATLIYVTLYFFLPKFYEKYKTDQL
                     QTGIEEIIDKSKDLTLQNATPLVDEYAQKNNAIIYLQDNEGRLIYSPFLQSTIQGSTIQ
                     EGTVRGGTVQGGTPAKGFVTTVPIKGLAQSRNSYEATKPIQFQDVDLTLVVFATFQPID
                     EASQVLVRFLPYISIIVLVIGLGSAYLYSRFITKPLIYINKGAQKMAKLDFSEKIEVRS
                     MDELGELSNSLNDMSINLQQAIFDLQKANQQLKSDIEKEREIETKRREFFAIVAHELKT
                     PLTVMKGYLEGMIYNIGPYQNRDQYLKKNYQIIESLEQLVREILSMSKLEQHTFKLQVE
                     EVNLSRSIDTITKKLEFFASQKGIQIIKEVDSDIFVYTDYVLLEKACKNIIHNAIMYSP
                     YNEKVYIKLTKDSKQNNIQMRVINTGVKIKEEDIQHIFKPFYRIEKSRNRNTGGSGLGL
                     YIVKQIFESLFITYSINNTKQGVEFLVTIPLSSE"
     gene            complement(17495..18160)
                     /locus_tag="GE376_RS30975"
                     /old_locus_tag="GE376_30990"
     CDS             complement(17495..18160)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002200383.1"
                     /locus_tag="GE376_RS30975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GE376_30990"
                     /product="response regulator transcription factor"
                     /protein_id="WP_002150943.1"
                     /transl_table=11
                     /translation="MKNYHILVVEDDQEIQELIKQFLMTQQYKVIVASDGLEGMKQFNK
                     QSFDLILLDVMMPNLNGFEVAKMIRSQSNIPIIMLTALEEEQDQMKGFDLGIDDYITKP
                     FSFHVLMRRVEAVLRRSNNQSTDNHFVFRELHVDGDAYKVYVNKVEVPLTTKEFEILQL
                     LLQNEKKVLTRENIVEKIWGYEYAGDTRMIDTHMKNIRKKLDIPYIKTVKGIGYKIDE"
     gene            18325..18495
                     /locus_tag="GE376_RS31760"
     CDS             18325..18495
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016127344.1"
                     /locus_tag="GE376_RS31760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_170959383.1"
                     /transl_table=11
                     /translation="MSLEANIILSILDVQLWIAPHLNNRRIKEKKQKLKPASCLNKYTS
                     VNKRKLYKSSE"
     misc_feature    18811..18824
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: strong, score: 19.16"
                     /tool="antismash"
     gene            19100..20308
                     /locus_tag="GE376_RS30980"
                     /old_locus_tag="GE376_30995"
     CDS             19100..20308
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000494788.1"
                     /locus_tag="GE376_RS30980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GE376_30995"
                     /product="trypsin-like peptidase domain-containing protein"
                     /protein_id="WP_153218584.1"
                     /transl_table=11
                     /translation="MFTMGHYDTNQTESNKNKAYKKTGYFFTGIIGAVIGAITIGLTTP
                     YINEIKGSAGQSPKHNEVNQATPISYKPEDVSNPQNMIESAKEVVVGVINYKQNADSFN
                     TQDQSEEAGSGSGVIYKKNGNKAFIVTNNHVIDGANKVEVKLNNGKKVPAKVVGTDPLL
                     DLAVLEIDGADVKRVATLGDSEKIRTGETVIAIGNPLGLEGSVTKGIISSKEREIPVST
                     LGNQQVDWQAQVIQTDAAINPGNSGGALFNEQGEVIGINSSKIAQQAVEGIGFAIPIHI
                     AKTTLESLEKEGTVKRPMMGVQLLDIEKITDSARNQLKLPKEITSGAMFGNISSQSPAE
                     KGGLQQYDVVIALDEQKIENVVQFRKYLYKKKKLGDTIKVTVYRNGEKLTKNVKLTDQT
                     RAA"
     misc_feature    complement(20392..20405)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: strong, score:
                     18.15"
                     /tool="antismash"
     misc_feature    20799..20813
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: medium, score: 24.13"
                     /tool="antismash"
ORIGIN
        1 tccaccagct gctttagctc ctaaaaagtt cataagagtt acaaatgttg ctgtgataat
       61 tgcaattgcg ataattagca ttttgtgttc attaacattt aggccaaata aactaaccgt
      121 ttgtgtcccg aaaataatag caagagctgc aatatttgca gggaagtata tgacagtttg
      181 tgcccagcca agcaagaaag cagttaagtt tccataagtc ctctttaaat atgccatcat
      241 tccccccgtt tcaggaatag cggcagatag ttcagcagca gttagtcctg cgcaaacggt
      301 caagatacca ccaattaccc atgcaagtaa tcctaggcta gctgtgcctg ttactccata
      361 taatgcagtg ggcttgaaaa atactccggc gccgataacg gtaccaataa ctgtggttaa
      421 tgctgcaaag aaaccaatat ccttttttag ttgttgttgt gacaaaataa tcactcccaa
      481 ttagaaaaat atataaattc tcttatgaat tctttatcct gtttgttaaa ttatttgata
      541 gtatatcctg tatccataca aatagccgcc cctcatcctt accagctaga gaatttcaat
      601 acatttcaga tactaaataa aaaagaaatt aaacttataa gtaaagaaag tttaatttcg
      661 cctcaaatca tgtgaaaatt ttcacatgat ttgaggcgag taaaattcca tgaattatac
      721 attaaaagaa attctttaat ttaacccgaa acatgaagtt aaaaacgaga tttcttttat
      781 aggaataata aggataaatg aggtattttg atattgtgat atagtaaaat tgtaaatcaa
      841 aattcaaaag agaagatata ttcttgtgaa gaatatcaca aagtattgag ggattcaatc
      901 atattttcga tataaaatat agaaaatcaa ctaaataaaa cattttgtga aatgtttcac
      961 aaaattgttg acccgttatt tttactaatg gtatgttgta ggtgcaatcc aatgttataa
     1021 attaaattat atttaaaaaa tattgtaagg gcgaatattt tgaatcttat atttatctga
     1081 caataattaa tttaatttat aactcactct aaaaaaggat gtgtagatat gaaaattggt
     1141 gtagtgaaag agataaaaaa aggggaagct cgtgtaggga tgactccaga aaatgttcaa
     1201 aaattagttt cagctggaaa tgaagtttta gtacaaaaag atgctggatt aggttctggt
     1261 tatacaaatg ttgaatatat aaatgcagga gcaagcatag taaatcaagg ccaggcatgg
     1321 gatgttgata tggtagtaaa ggtaaaagaa ccactacctg cagaatacca ttactttaaa
     1381 aaggatctaa ttgtatgggg ctttttacat ctggctgcgt cgaaagagtg tgtagaagca
     1441 atgaaaaaag ctggaactac tgcgattgct ggtgaaacta ttagtgagga tggaaattta
     1501 gcgttattaa aacctatgag tgcaattgct ggaagacgtg cggtatttat gggagcttat
     1561 tatttagaaa aacaacatca aggagagggg attttattat caggtattga gggaatccca
     1621 gccggaaaag ttgtaatcct aggtggaggg aatgctgcaa ctaatgcctg tgatatggca
     1681 attggaattg gatgtagtgt tacaatccta gaggttaatc aagaaagaat tgcatattta
     1741 agaaagcaat acgcaacaga agaagtaaat ataattgaat ctaatactga aaatctagag
     1801 cgaacgatta aagaagcaga tttatttatt tcaacaattt taataccagg atctcgccct
     1861 cctaaaattg ttaaagagta tatggttcaa tctatgaagc caggaagtgt cattgtggat
     1921 atcgcaatag atcaaggtgg tacagtagaa actattgatc attatacaac tcatgataat
     1981 cctgtattta ttaaacatga cgtaattcat tatgcagtac caaatatgcc tggtgccacc
     2041 ccacgtactt caactatggc gttggcaaat ggaaatattg agtatttact agcaatttct
     2101 aaagatggat tagaaaatgc aattcaaaat aaatcatcat tagcatctgg ggtaaatgta
     2161 tataaaggta ttattaccta cgaaaattta ggtatgacgc taggtttgga ctttaaacaa
     2221 ttgaaagaag tgttagtatg attaccaaaa acgtattgtt agatatcact aacattaaaa
     2281 aagccaaaga aattcttgat gtaaatgccc gaaaaacacc tttggttaaa tctttctatt
     2341 taaccagtaa aaccggtgga gaaatttatt tgaagttgga aaacatgcag ttaacaggtt
     2401 cattcaagtt tcgtggtgca tttaataaaa tttctcaact tacaaatgaa gaaaaagaac
     2461 gtggtgtaat cgcctgctca gctggaaatc atgcacaagg tgtcgcatta tcttctcatt
     2521 tacttggaat caaaagtaaa attgtgatgc caacctctgc accacaagct aaagtggatg
     2581 cgactagagg atatggttct gaagttattt tatacggtga tacatttgat gatgcaaaag
     2641 cgaaatgtga agagattata aaagaaacag gcgaaacata cctacatcca tatgatgatg
     2701 tagaagtaat ggctggccaa gggacaattg ggttagatat tctggatgat atgtgggatg
     2761 ttgatactgt tattgtacct attggtggag gaggaattat ttcagggatt gctgtagcac
     2821 tgaaatcatt taatccatcc attaatatta ttggagttca agctgaaaac gtacacggta
     2881 tgaaagcttc ttatgacgcg gggagaattt tagaacacta tgaagcacca acaatagcgg
     2941 atggttgtgc agtaaaaata ccagggaatt taacttttga aattgtaaaa gacctagtag
     3001 atgacattgt aactgtatca gaagaagaat tagaagtagc gatgaaagac ttactacaac
     3061 gcggaaaggc tgtcgtagaa ggtgcgggag cattagccac agccgctctt cttgcaggaa
     3121 aagttgataa atatgtacag ggtaaaaaag tagtagcagt tatttcaggt ggcaatgtgg
     3181 atttaaaacg tatttcaagt gtatgtgagc atttctttgt tgccaatgag gtaaaataac
     3241 tattcaataa tcttataaaa taaaattatt ttacttaagg ggagctagga gacgatatct
     3301 tagctccttt ttaaataaaa ggaggcgtgt gttatggcca acttatttag gaaaaaatca
     3361 gtaaggaaat tgttggaaga tagtaaaagt aagactttga caaaaacgtt gggtgcattt
     3421 gaccttacca tgctagggat aggtgcaata attggtacag gagtacttgt attaactgga
     3481 ttagtagccg caagagatgc gggtccagca gttatttttt catttatgat tgccgcaatt
     3541 gtttgtgggt ttgcagcctt atgttatgcg gaaatcgcat ctgctcttcc agtctcgggt
     3601 agtgtataca cctattcata tgcgacgatt ggtgagtttg tagcctactt aatgggatgg
     3661 actttattgt ctgtatatat agttacaact gccgcagtag caggtggatg gacaggctat
     3721 tttcacaact tattaaacgg atttgggatt gagataccaa gatcactgtt aacaattcca
     3781 acacaaggtg gaatcgttaa cttaccagca gtaatcatta ctttggtatt aacttggtta
     3841 ttatcaaaag gcacgaaaga aagtaagcga gtgaataacg caatggtatt aataaaaatt
     3901 ggtattgttg ttttattcat ttcagttggt atattttacg taaaaccaga aaactggatt
     3961 ccgtttgcac cttatggtat aagtggaatc tttgctggag gagctgcagt attttttgcc
     4021 tttttaggat ttgatgcgtt agcaacgtct gctgaagaag taaaaaatcc acaacgtgat
     4081 ttaccgattg gtattattgc ttcgctagtt atttgtacaa ttatttatgt tatagtttgt
     4141 cttgttatga ctggtatggt ttcttataag gaattagatg taccagaagc aatggcctac
     4201 gtattagaag ttgtaggaca agataaagta gcgggtataa ttgcagttgg agctgtaatt
     4261 ggtattatgg ctgtaatttt cgcttacatt tatgcgacaa cacgtgtatt cttcgcgatg
     4321 agtcgtgacg gtttattacc aaaatcgttt gcgaaaatta ataagaagac agaagcacca
     4381 gtattctcaa cttggttaac aggtattggt agtgctttaa ttgctggatt tatcgattta
     4441 aaagaattat cgaatttagc gaatattgga gcgttattaa catttgcgat ggttggtgtg
     4501 tcagttatta ttcttcgtaa aacacatcca aatttaaaac gtggtttcat ggtaccactg
     4561 gtaccaatct tacccataat ttcaataaca agttgcttat tcttaatggt aaatttacct
     4621 ttaaaaactt gggtttattt cggtatttgg ttatttatag ggataatggt atattttatg
     4681 tattctaaaa gacatagtca attaaacaaa ctataaatga gatatatcag agacagaggt
     4741 tatcacgacc tacatgtttg agcaagtagg attcttctct tttgggaagt accttttctt
     4801 tttataaaaa atttaatcaa aagaacttga aagtttatgt tatacgtaaa aaaacgaatc
     4861 tatttttaaa atagattcgt ttttttaggg acattccata tttaaaagat gtgtggttaa
     4921 tatccgctta tatttttttc tttggaatag tgaaaattct taaatctatg agcaagaaat
     4981 ctatctaaac gctatcaagg tgatattttg aaataacaaa tagatataaa gtaccaagca
     5041 tgtacacaat aagaacaaat aaccctttgt atacaaatac acatcaggaa gcaaaaatat
     5101 atttatctta aacataataa ctcacgtttt atttttttgt atagttagtt actaaaaacg
     5161 aatggagagt atgtgtttat gaaaataaac cagtcaaatc ttaaaggggt atggaaaaaa
     5221 agaatattaa tatttctttt gattgttttc ggattgatta ttgcaggagt tagttattgg
     5281 aacctttcac ctactccaaa agcgtttctc ataaaaaaag catttgaagg tggaatgttt
     5341 gttcaatcgg ataattatca aaacgcttta aaagaaacac aaattgttaa ggacatcaat
     5401 tataattcta aatttcccga tggtatgtta gacattattt atccgaaaaa ccatactgat
     5461 aatacacctg ttattttttg ggtgcatggg ggtggatttg taggtgggga taaatccgat
     5521 atcactggtt atgcagtaga attggctgct aagggttatg cagtaataaa tataaattat
     5581 gctcttgcac ctaagatgaa atatcctaca ccagtattcc aacttggtga ggcttatgaa
     5641 tatataaaag aaaatgcaaa gaaatataat ttaaaacttg aacaggttta ttttgcagga
     5701 gattctgctg gagcacaaat atctggacaa ttcgttaata ttcaaacatc tgccaattat
     5761 gcaaggttaa ctaaaattga tcctgttgtt gagcctgcta caattaaagg tacgttacta
     5821 ttttgtggtc catataatat gcctgcatta gctaaaatgg aaacaactaa agaagtacaa
     5881 gattttatgc gtaccactgg ttgggcttac tttgggaaaa aggattttga aacattacct
     5941 gaaatagaaa ttgcttctat cattaaacac gttacaaaag attatccacc aacatttatt
     6001 acagatggaa atactgcatc attcgaagat caagccaaag cactagcgtc tgagttagaa
     6061 agtaaaggag tacctataga aaaactcttc tttgataaaa atatttctgg tgagttggct
     6121 catgaatttc aatttaaaat gaacacacca gcagggcgag aaacttttaa taaagttctt
     6181 gaatttttaa atgaaaataa atagtttgcc taaaatcgaa tacaaaagtt caaccatcat
     6241 tttaaattat aagaactacg ctatcttttc tgtggaatcc taggaaagat agcgtttttt
     6301 tctcttaata acttacaaaa ttaaactgaa atagaaaaaa ggaatgaatt attcggatga
     6361 tagtaaatgt cttagtgatt tcaatgtata tatgacaaat cagtttgtat ttatttcctt
     6421 gataggattt tacataatat taattttttg tgaattatta atctgaaaat aatttgattt
     6481 aaagtactat tcatacgaaa tgaatacctt tatgtaattt atttgattta taagatagtt
     6541 aagaatacca aatcaaaaca taaaagctca ttattgattg atattttata aagttgtatt
     6601 aatatgtgtc ataaaataat ataaaaatat aattataaat agaataaggg aggactatgt
     6661 aaaaaagtaa taaatacaag ttcatgaact gtttttgcac gtaagtacat gctaaagaaa
     6721 ccaaaactat taaattgatc aaggaaatga gagggagata ctatggggaa taaatcaaag
     6781 tataaaacca aaagaatact agtagctact gcaacattaa ctataattgc ttctggaatg
     6841 gcttcttcat cagatgtctt tgcagaggaa acgcagcagc aaaaaagttt atcgacatca
     6901 ctgcaaagtg aaaagtcagt caaatctgaa aatagaacat ttacagtccc aggaaaaggg
     6961 gatgttgagg tactgaaaca acaggaaaga aaaagtatgg catttagtcc atatgaacca
     7021 actggtttat atgcaaagcc aaatgaacaa ataacgatta atgtagaagg taatcaagat
     7081 attcaggtat atattggaac gtattcgtat gatgcttctt ggagagaaga ttctaagata
     7141 aaatcattta cattaaaacc tggtgtaaac acaatccaat ctccaaatgg ggggctgatt
     7201 tatttttata ataaacagca aggaggtagc attcgaacaa caattacaac aggtggaacg
     7261 actacgcctt tctttgaact aggaaagcat acgaaacaag atttaataaa catgctggac
     7321 caatatccta atgcacatgc agtggagtta aaaggcgaac gtgtattaat tacggccagc
     7381 cctgcacgtg ttaagaaata tttgttgggt tctaatacag atcctgtaca actcttaaaa
     7441 aagatggatg aagctactcg aattcaggac aaagtagctg gattatctga ggaacaagta
     7501 gataagcact atattcatta cgtagaagaa aatcattctc ccgattatta tatgtatgca
     7561 tatccttatc gaaccgctta tgtaggagat gccattcaat atgtattaga tatcaataaa
     7621 tttactacgg atggatgggg accttggcat gaagctggac atttgagaca acagattcct
     7681 tggagattct ataatatggg cgaagttcaa aataatattt acagtctcgc tgtagaaaaa
     7741 gcatttaatc aaccatcaaa tttggagaaa agcggaactt atacgaaagc ctttcaatat
     7801 ctagaacaaa cgaataaaaa ttatgacgaa attagtgatg tttttgttaa acttgttatg
     7861 ctttggcaac tacagttagc atatggagag gatttctatc ctaaattgca tcaattatat
     7921 agagacatgc cttcaaatga gattccacaa actgatgaaa cgaaaaaaca attatttatg
     7981 atttcagcat caaaggcagc aaaacaaaat ttgattcctt tctttgagaa gtggggatta
     8041 cgtccaaata acgatacgat tcaaaaagtg gctgcattag ggtatccaat tttaacagca
     8101 gagatttgga agagtacgga ttctaatcca attaaaccag atatgcctaa tgaaaataat
     8161 attttagaag gaaaccagtt tgcatggtca ctaaaaggaa ttggtgattt cgagtttgct
     8221 aaaattaatt tcaataaatc gaccgaagaa atgcaagtgg acttaaaagc aggcgtacca
     8281 catcattatt ttaatgaaac atatgcgagt attaaagtac aaaatgcatc agggaaagta
     8341 gtatacaata aagacattta tggaaataaa caacaaaatg ctgaatcaca aaaagtttcg
     8401 gtcaaggtag gagactatat agagttaaca catctagaag gtgtgcatag agctactctc
     8461 acaaatgtag ataatagtaa acaagagagc tttggaaaaa aagccatata tgaagttaca
     8521 aaagaaggtc taaagaaagt agaaaaaatg ccagaagcaa caattttaga tggaaatcaa
     8581 tttgcatggt cattaaaagg atatagtgat agagaaattg caaaagtaaa ttatgataaa
     8641 acagtagaag agatgaaggt aaaactagaa gcaggtgtac cccattccta ctttactagt
     8701 acgtatgcga gtattaaggt ccagaatgct tctggcaacg ttctgtacaa taaggaaatc
     8761 gtgggaaata aacaacaaaa tgctgaaagc caaactgtgc ccgttaaaat aggtgattac
     8821 attgaactta ctcatataga aggggaagca acaaaggaaa agacgagagc gactttaatt
     8881 aaccttgaaa ataacaaaaa tgaaaccatt ggaaagacag caagatatca agttacaaaa
     8941 gaaggcctga agaaagtaga aaaaatgcca gaaacaacag ttttagatgg aaatcaattt
     9001 aactggtctt taaagggata taatgatcga gaaatcgcaa aagtagagta taacaaagca
     9061 acagaaaaaa tgcagattaa attagaagcg ggtatccccc attcctattt tactagtacg
     9121 tatgcaagca ttaaagttca aaactcatcg ggcaatatat tgtacaataa agaaattgta
     9181 ggaaatagac aacaaaatgc tgaaagccaa accgttccag ttaaggtagg ggattatatc
     9241 gagtttactc atatagaggg agaagcacag aaggaaaaga cccgtgccac acttactaat
     9301 cttgagaata gtaaacagga atttgtaggc aagaaaaaaa catatcaagt tactcctaca
     9361 ggattattaa taaaatagat aaaaaggatg tcaaaaaaaa tagaattttt tttgacatcc
     9421 ttttttatta ttaaaaaacg ctaattatta atagtgatat aggatgaatt ctatagccca
     9481 ctaactatta tatatactca aaaaatcaag ttatagctaa tgttccaagg attgacacat
     9541 ctattcttag ttaatcatgt tatacttttc acaaatgaaa tgctacaata tcaaatccta
     9601 gttttatgac atccttctgt tgccacagtt tataaaaggt caattccaat gggattgact
     9661 ttttatagtt gtagcacaaa gttataaacg cccatattta ttataagata aatattgcaa
     9721 tttcacgtac cgtatttgtg aatgtataaa taattacaat aaatattatt ctatatgtag
     9781 ctttgcgata tgtaactgtt aaatagataa tattcaacct tctcgcgata ttttaaatta
     9841 aggttaaaag aaaggaacgt aaaataaagt aattcgttaa tatataagga tattagtaat
     9901 aatttgtggg aaattgaaga actaaggtat atgattgtga aaaaaatcac aaacatatac
     9961 cttagttctt caaaattatt tcaaaaggag gttataaaca atgaaaagaa ttataacact
    10021 gagcacttgt aaactgcaag atactataaa acatggtggg tgtggtgcat gtcagacatc
    10081 ttgtcagtct gcttgtaaaa cctcatgtgg agttgcaaat caaaagtgtg aaaatacaat
    10141 aaataggaaa caagaagtat agtattcaat tatattttat ttaggtggca atctttatga
    10201 aaaaggagtt tggttatcca gtatgattca tcaatataaa ttaaatggat acaatatcgt
    10261 gttagatact tatagcggat ccgtacatgt cgttgacgat cttgcttatg aaataattat
    10321 gctatatcag aatactccta tggaagaaat cctgtcaata atgcaggaaa agtataaata
    10381 tgatttccac gtttccaaga aggaaattcg agaaacaatt gcggatattg aagaactaaa
    10441 aagagatggg aagcttttta ccgaagatga ttatagggac ctttcaattg atttgataaa
    10501 tcgtcccact tatgtaaaag ctctttgcct taatgtcgcg catacatgta atctgtcgtg
    10561 tgaatactgc tttgctagcc aaggaaaata caatggaaat agagccataa tgagttttga
    10621 agttggaaaa agagccatag attttctatt agaaaactca ggtaatcatc gaaatctcga
    10681 tgttgatttt tttggtgggg agccactcat ggcgtggaaa actgtcaaac agattgtcgc
    10741 ctatgcaaga aataaagaaa aagagtacaa aaaaactttt cgttttacct ttactacaaa
    10801 tggtatgctg cttaatgatg aaattactga attcttaaat caagaaatgc acaatgttgt
    10861 attaagcctt gatggaagaa aaaaagttca tgattatctt cgtaaaactg tcaatgggaa
    10921 aggtagctat aatcatatcg ttccaaaatt ccaggagttt gttgagaagc gtggagataa
    10981 agaatactat gtacgtggaa cctataccca taataatgtt gattttacca atgatattta
    11041 tcacatcgct gacttaggtt ttaacaaaat ctcaatggaa cctgttatct gtaatcccca
    11101 agaaccatat gcgctctgtg aagaagacct gctggaaatt tacaatcagt atgaaattct
    11161 ctcgaaagaa atgctaaacc gtgaggaaaa aggaaatggt tttacatttt atcattacat
    11221 gctcgacctt tcagaaggtc cgtgcgttca aaagagaatt tctggttgcg gttcagggac
    11281 tgaatatcta gctattaccc cgtgggggga gatatttcct tgtcatcagt ttgtgggaga
    11341 agaagaatat agtatgggga atatatggga tggcattata agagcagaga tacagtctca
    11401 gtttaaggaa agtaattgct attcaaaacc ggaatgtcag gaatgttggg cacagcttta
    11461 ctgtagtggc ggttgtccag ctaatacaat acatgcaacg ggttctctta agggaacaca
    11521 tgagttcagc tgtaaaatct tccgaaagag aatagaatgt tctatgatgg ttaaagtagc
    11581 tcaatccatt agagctatga agaaggaaga acaaggcatg gttcagtaaa taaaaaagtg
    11641 cacaagtgtt gttatagcat aaatttataa agatagttac aaacaagaat tctttagtcc
    11701 aatttagaat aaatgagttt aaaagaagat agccatttgt aatggctatc ttcttttgta
    11761 aaaaatatat aatttattca attatttttt cgataacagg cataacagcg attggtggaa
    11821 tagagtgagt ccatcctacg gaaaatatat ttagtttttc acctacgcta tagttatcct
    11881 tgctagtaat aggaacacgt aaaattttat tctgagaagc taattcccac caattatttt
    11941 gataagaaag tgcctcctct tttgtattag tgtcagctac aactaaataa ttatcatctg
    12001 ctgaaataac atatccagta aaaggtatct gtattcttac ttgttcttcc ttaataggag
    12061 tagaattact tatagaatct gcggaagtag gagttaatcc gaaaactaat ccacatccta
    12121 gcgtcagagt ggtaaccact gttactaatt tttgtttttt tgaaaacata atataaatcc
    12181 cccttatatt ttatccgtac accatcacct ttctattttt tatatagaaa gcctttttat
    12241 atccctaaat ttaacaatta tgtcacaaat aatccattgt tttttcaaat gggtattatt
    12301 taaagataat atatgttata attcaccaaa ttaactatta attttacctc tatcttctag
    12361 tgaatatata tttttgaaaa gaatgatagc gctatctttt gtaaatgttc ctatttgcat
    12421 gattacctaa tttttatgta caataaagaa aagagagttt cttagacagg aagaggaaag
    12481 tcatgaccaa gtcattagta aatttacgaa ttgattttgc ttttaagcaa ttatttggga
    12541 caagtggtag tgaggatatt cttatcacat ttttaaatgc catgctaaag aattcattag
    12601 aatcacctat tatgtcacta caattagagg atccacattt acatcgagaa cacgaggatg
    12661 ataaattatc aattttagat gtctcagcca cattagacac aggtactaaa gtaaacgtag
    12721 aaattcagct gaataataat cacgacatga ttaaacgaag tttgtattac tggggtaaat
    12781 tatatacttc acagttacaa aaagggatgc cttacagctc tcttagtaaa acaattacta
    12841 ttaatttgtt aaacttcgta ctttttcccg aatatgagga atttcataca acgggaaagc
    12901 tatggaatgt acaacagcaa aagcagttta gtgatgatat agaaattcat gttatagagc
    12961 ttcctaaact aatggaacaa tggcgggaag agaaagttaa tccgtgggaa gattcatttg
    13021 ttcgttggct gttattactt ccggcaaatg aagatgaaca cttaactcaa acattggagg
    13081 acattgcgat gaatcaagat ccgattttac aaaaagcaat gaataagtgg gagcgaatga
    13141 gtcaagattc gacattccga caagcctatg aagcgaggga aaaaacccta atggatgaag
    13201 ctgcaaagtt tgctcacgca gaggagcaag gaatcaaaaa aggtattgaa aagggtattg
    13261 aagaaggcaa aaaagccgaa cgtatacaat tggtatgtgg tatgtataaa aacggaatgt
    13321 ctgtagagga tattgccaaa tttacgaagt tacctataga agaaataaga gaaattatcc
    13381 aattataaat aaaaaagaac acctacagca tttgtaggtg ttctttttta tgaccaataa
    13441 tgtccggagt ataattatta gttgatgtat cgtcaggaaa ataagaattt acaacattaa
    13501 atatctttta aaaaacttac atggattcta ccttaaatac atgctctata ttccatcata
    13561 atattgttaa taattgtttg gacgggcaat atctctttga cttcatttac tcgtgcacct
    13621 gcgaaaacaa gaccattttc acaatcacca tccatagagg ttatcaaaga atctagcgtg
    13681 cagaaacgat aagaacagtt ttttaagcaa tttatacact tttttatttt tatcttttta
    13741 ttattatcag ctattaattt agtaaagtta tttttaaccg cacgaccttg gagcccgaca
    13801 gttgttttga ctaatatggt atcttctaat cgagcattta tatatttttc cttaaaggat
    13861 agtggtgcgt cacactcatt acttgcaacg aatcttgtac ccatttgcac accagatgca
    13921 cccattttta aggcacgagc aatatctttc ccagtcataa ttcctccagc agcaattacg
    13981 ggaattttga ctgctgcaac tacttccggt aatatatcga ataaaggtcg atcggtaccc
    14041 agatgtcctc ctgcttcatg cccctctact acaacagcgg ccgcacccaa gcgttcagat
    14101 aatctagcga gtttggctga ggatactatt gaaataactg gtatgccggc atttttcccc
    14161 caagtataca tatctcgtga aatgccagca ccagatatga tgaaatcaac tttttcctca
    14221 atggctgctt tcattttttc agcaaaatca ttcattgcaa aaaggacatt tactccaata
    14281 taaccagtat tccgaatctt ttctttcgcc ttcctaatat gcattctcat ttcatctatg
    14341 gaaataccag ttcctgatat aatcccaatt cctccagcat ttgcaactgc agatgcaagt
    14401 ttacttaatg aaatgcctac gcccattcct ccctgtagaa ttgggacctt tggcatcata
    14461 tgcccgattt ttaattgtgg aaagttcaag taaatacccc atttcattaa tgttattaga
    14521 gtagatctgt taaacccctt cagtttaaca cggtgtttgg aacaaacaca ggaaattaat
    14581 acctgctact agtagtttgt aatgtttttt gatgattttc acaaaatgtt cgaatagtgc
    14641 gctataaatt ttagaataat atcaaatgta tattaaggat tctggataaa aaacaacgaa
    14701 atttagattt tctaacaaaa aatgttatta aaaaattgat ttgtcaaaaa tgaagtggga
    14761 tgtaatcatt aattatttta agcggggata tgaacagagc taaatagaag tttatatgct
    14821 ttttaataaa agtaattttt gtattataag tgttaaataa tcaatagttg taaaggaaaa
    14881 aatctatgtt tttagtaatc tacacgattg gattagagac aattagatgt gtagtacatt
    14941 ctagaagttt taaatatcaa tattccaaaa atcttgataa tcaatatgct tatcaaattt
    15001 ttttagtatt ctaatgattt tagttgcaga tgttaaagtg ggaatacgat cctttttatt
    15061 tgctaaatca cttatcagag atttacttaa tccagttctt tgtacaagcc attgttgttt
    15121 gattcctctg tgatctaaat actcaccaaa tgaagttctt ttttttccta gaccaaacat
    15181 aaagaatccc tcctattaag aatgatgtat aaatagcttg tacaaaattc cataaattta
    15241 aacttttgtc cataaatatg gaattataat ttagaacaaa gcatagaata atataaatat
    15301 aatgaaaaaa tatggaataa ttttgaggaa tctagcattc atagtaatag ctacaagttg
    15361 ctgatacact atcctaatgg caacttgttg caaagggtat tactaaaata aaaaaatctg
    15421 aaactcctta cgtcagaagg gttttcagat tttttctttt ttagatcttt aatttataga
    15481 tacgtatttt atagattatt atgcataata tggcgaatga gtagaatgga ttatctgttt
    15541 atatagtttg atcgaccttg ttactaatca tataaatctg ttttagatat gatgaaagga
    15601 aatactgaga aaaaatgtga aatccgaaat cagtcatatc tggtccagta tactcatcac
    15661 tttctaccca gctgttaagt tatcagtttg tagtgaaaaa agtacagtcg gccagtttgt
    15721 gtaacaaaaa atatttctat cccgtctaca aatgattcat taatatacaa ttcaggtatc
    15781 atacttatat tataaacact atgaatcctt ttttgtttca taaattctct tccgttaata
    15841 cacttgcaag tgtattattt tggatcttta tgtgtcaaat gaataatgtt tttatctgaa
    15901 ttttcttcac catattatgt ttgggttgcc atacccaaca taatatgaaa aatctcaatc
    15961 tcatttttat aggatgaaat gagattgaga ctcttttgtt gtttattcgc tggataatgg
    16021 aatggtaact aaaaattcta cgccttgttt ggtattattt atagaatatg tgataaaaag
    16081 ggattcaaaa atttgtttta caatatataa ccctaagcca ctccctcccg tatttcgatt
    16141 tcttgacttc tcgattcgat aaaatggttt gaaaatatgt tgtatatctt cttcttttat
    16201 tttgacacct gtattgataa ctcgcatttg gatgttgttt tgtttagaat cctttgttaa
    16261 ctttatatag actttttcgt tataaggtga atacataatc gcattatgaa tgatgttttt
    16321 acatgctttt tctaaaagaa cataatccgt ataaacaaaa atatcagaat cgacttcttt
    16381 tattatttga atgccttttt gagaagcaaa aaattcgagt tttttggtaa ttgtatctat
    16441 tgatctcgaa agatttactt cttccacttg aagtttaaag gtatgttgtt ctaattttga
    16501 catgcttaaa atttcgcgaa ccagttgttc cagactttca attatttgat aatttttctt
    16561 taaatactgg tcacgatttt gataagggcc gatattatat atcatccctt ctaagtatcc
    16621 tttcataaca gtaagaggag tttttaattc atgtgctaca atagcaaaga attcccttcg
    16681 ctttgtttct atttctcttt ctttttcaat atcacttttt aattgctgat tcgctttttg
    16741 taaatcaaaa attgcctgtt gtaaatttat agacatatca ttcaagctat tggacaattc
    16801 ccctaattca tccatagaac gaacttcaat tttttcggag aaatccaatt ttgccatctt
    16861 ttgtgcacct ttattaatat aaataagtgg tttagtaata aaccttgaat agagataagc
    16921 acttcctaaa ccaataacca gtacaatgat actaatatag ggtagaaaac gtactaagac
    16981 ctgtgaagct tcatcaatcg gctgaaatgt tgcgaacacc acaagcgtta agtcaacatc
    17041 ttggaattgt attggcttgg tagcctcata tgaattacga gattgagcca aaccctttat
    17101 tggtacagtt gtaacaaaac cttttgctgg agtacccccc tgaacagtac cccctcgaac
    17161 agtaccctct tgaatagtac tcccttgaat agtactttga agaaaaggag aataaataag
    17221 ccttccctca ttatcttgaa gatatataat tgcattattt ttttgtgcgt attcatcaac
    17281 aagtggtgtt gcattttgaa gcgtaagatc tttagattta tcaattattt cttcgattcc
    17341 cgtttgaagc tgatctgttt tgtatttctc ataaaattta gggagaaaga agtataaagt
    17401 tacatatatt aaggttgcaa aggctaacaa aatgagggat gtagtcataa agagtttata
    17461 ggtaattctc ttcatcttca tgatttttac aatcttattc atcgatttta taaccaatgc
    17521 cctttactgt tttaatatag ggtatatcta atttttttcg tatgtttttc atatgcgtat
    17581 caatcattcg tgtgtctccg gcatactcat atccccaaat tttttctacg atattttctc
    17641 ttgtgagtac ctttttttca ttttgaagta gtagttgcaa aatttcaaat tcttttgtcg
    17701 ttaggggaac ttcaacttta tttacatata ctttatatgc atcgccatcg acatgtagtt
    17761 ctctaaatac aaaatgatta tccgtacttt gattattact tcttctcagt actgcttcga
    17821 ctcgtctcat caaaacatga aaagaaaaag gtttcgtaat ataatcatcg attccaagat
    17881 caaatccttt catttgatcc tgttcttctt ctagcgcagt tagcataata attggtatat
    17941 ttgactgact tcgaatcatt ttggcaactt caaatccatt caggtttggc atcatcacat
    18001 ccagaagaat taaatcgaag gactgcttat taaattgttt catgccctct aatccgtctg
    18061 atgcaactat aactttatac tgttgtgtca ttaaaaattg tttgattaat tcttgtattt
    18121 cttgatcatc ttctaccacc agaatgtgat agttcttcat aatatcacct cttatagtca
    18181 ttataacctt ctaatctgga gttgatgtgg agacgtatta gaaacactat aaaaacttca
    18241 caagaaaact acatgtattt caaattagct ccagatgcat gagataggtt atatacataa
    18301 caagacagag gggggggaat taagatgtca ctagaagcaa acatcattct ttctatatta
    18361 gatgtacaac tgtggatagc tcctcatttg aataatagac gcataaaaga gaaaaaacaa
    18421 aaattgaaac cagcatcgtg cttaaacaaa tacacaagtg taaataaaag aaagctatat
    18481 aagtctagtg aataaaaata gggaggatca aattgattct ctctattttt gtattccata
    18541 attaggtact gaaagtcttt actataactc tagattaact ccatatagaa tacagattaa
    18601 gtttgtatga tacatgtacc aaatagaaag gaatgataca tgatgttgac gacttacaca
    18661 atctatcaaa ttttatccct tccttcttat ttacacacaa acctattacc atccattctc
    18721 acgagaatgc taggatctaa gtttataaca aaagaataaa taggctaatg gatgtttatt
    18781 gtcccttgtt tccactattt gcaaaacacc tgtataaaca tgcatgctac tatgtacatt
    18841 gaatactcta tttgttgaga gccgaatagg ctcttttttt agagagaagc ccgaagtggg
    18901 tgtaaatatc gttatatata tttgtagaat aattcaaata taattttacc tctacgaaaa
    18961 aacagttgat ttatgtctaa accatgccta aaggtaaaat tttctttttt tgaaatggtg
    19021 attcctaaat attacattca tacatcgtat ttcaaatatg aagacaaaaa tattcaattg
    19081 taaattaaag gagaaaggga tgttcacaat gggacactat gatacaaatc aaacagaaag
    19141 caataagaat aaagcctata aaaaaacagg gtattttttc acaggaataa ttggtgcagt
    19201 gattggtgca attaccattg gattgaccac cccttatata aatgaaatca aaggaagtgc
    19261 aggtcaatct cctaagcata acgaagtaaa tcaggctacg ccgatctctt acaaaccaga
    19321 agatgtgagc aatcctcaaa atatgattga atctgcaaaa gaagttgtcg taggtgtcat
    19381 taactataaa caaaatgcag attcatttaa tacccaagat caatcagaag aagctggttc
    19441 gggatcaggg gttatatata aaaaaaacgg caataaagct ttcattgtta caaataatca
    19501 tgtgatagac ggtgcgaata aagtagaagt gaaattgaat aatggtaaaa aggttcccgc
    19561 taaagtagta gggacagatc cattattaga tttagcggta ttagaaattg acggggcaga
    19621 tgtaaaaaga gtcgcaacac ttggagactc agaaaaaatt cgtacaggtg aaacggtaat
    19681 agctattggg aatccattgg ggctagaagg tagtgtaaca aaggggatta ttagtagcaa
    19741 ggaacgagaa atacctgtta gtacacttgg aaatcaacaa gtggattggc aagcacaggt
    19801 aattcaaaca gatgcagcta ttaatcctgg gaatagtgga ggagctttgt ttaatgaaca
    19861 gggtgaagtc attggaatta attcgagtaa aattgcacaa caagcagttg aaggaattgg
    19921 atttgcaatc ccaattcata tagccaaaac aaccctagag tctcttgaaa aagagggaac
    19981 agttaaacgc ccaatgatgg gtgtacagtt attggatatt gagaaaataa cagattctgc
    20041 acgtaatcaa ttaaaattac caaaagagat aacaagtggt gccatgtttg ggaatatctc
    20101 aagtcaatca ccagcagaaa aaggcggatt gcaacagtat gatgttgtga ttgcattgga
    20161 tgaacaaaaa atagaaaatg tcgttcaatt ccgtaaatat ttatataaaa agaaaaaatt
    20221 gggggataca attaaagtaa ccgtttatcg aaatggtgaa aaactaacaa aaaacgtgaa
    20281 attaacggat caaacacgtg ccgcttaaaa atatagccac ctttcggtgg tttttttata
    20341 tgtgcttttt gtgtgggtac tagatatatc agaggtggta aatgtcatga agcaaaaaga
    20401 atgcccacat tgtaattcca agcaggaggc taatttttct agcgatagca tctcattttg
    20461 tactgtatgg gtcataaata aagggagcta tcccgtgttt gtatcccttc ctcaagttaa
    20521 ttggttggtg actaatattt tatacctatt attattccgt ttgttctcat tccacattaa
    20581 atggattgac tctttaccaa tgttcaaaat caattacata ttttaatttg tgttccagtt
    20641 tttcttgact atattaacga atcactacat atgcactcca gataagccct aatatcttta
    20701 gataatctac ggaatatctt catataaact ccagatagtg tatatagaat aacaactatc
    20761 aaggaggtta ggaaaaatga attttataaa acgcgcaatt ctcagtatga aaaaaagaat
    20821 aggaacatca ttaattttga tggcggtctt tctgattgtt acaaatttag tgttggcagg
    20881 attcacaatt caaaatgcat caaaaaaagc tgcggatgca gcaagaaaaa aactaggtgc
    20941 agatgttact ttaggccttg attttgataa attaggtcaa caagctaggg aaacgggaga
    21001 gatgcctaaa ccaccaaagc tcaacacaaa agaaacagaa caattagcga agtccaagta
    21061 tgtaaaagac tataattata taacccataa tttcggaatt gcagatggat ttaaactagt
    21121 aggtgtttca gaaggtgaag aaggaaaagg taaagcagga atggtggcag cagcaggtgg
    21181 atcaggttcg agtacagaaa tagatatgaa ttcttctctt atgatagaag gagttcgcaa
    21241 gactgcatta caagaaagct ttaaaaatgg aaaaagtaaa atcgttgatg gaaaaccaat
    21301 tacagaacag atgcaagatc agaatgtagc tttaatggaa aaacgattag cggaacaaaa
    21361 caatttgaaa gtagggaata aagttaaagt tcaatcaggg gataagaagg aaactcttga
    21421 aattgaaatt atcggtattt acgaaacgaa tgagcaacca atgggtcaaa atacccctcc
    21481 tatgatgaat ccagctaata aactatatat gccttactct actttaaaaa aattagaagt
    21541 agatgaaggt atgagtagta ttcaagttgt gtacttattg aacgacccac aatacattga
    21601 tgcatttaaa aaagaagcaa aaaaatctg
//
