LOCUS       NZ_CP045606            25239 bp    DNA     circular CON 16-FEB-2024
DEFINITION  Bacillus cereus strain SB1 chromosome, complete genome.
ACCESSION   NZ_CP045606
VERSION     NZ_CP045606.2
KEYWORDS    RefSeq.
SOURCE      Bacillus cereus
  ORGANISM  Bacillus cereus
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus;
            Bacillus cereus group.
REFERENCE   1  (bases 1 to 5461537)
  AUTHORS   Batinovic,S. and Petrovski,S.
  TITLE     Bacillus cereus SB1 complete genome
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 5461537)
  AUTHORS   Batinovic,S. and Petrovski,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (05-NOV-2019) Department of Physiology, Anatomy &
            Microbiology, La Trobe University, Kingsbury Drive, Bundoora,
            Victoria 3086, Australia
  REMARK    Sequence update by submitter
REFERENCE   3  (bases 1 to 5461537)
  AUTHORS   Batinovic,S. and Petrovski,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (25-OCT-2019) Department of Physiology, Anatomy &
            Microbiology, La Trobe University, Kingsbury Drive, Bundoora,
            Victoria 3086, Australia
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: NOV-2019
            Assembly Method                   :: Unicycler v. 0.4.8
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 46x
            Sequencing Technology :: Illumina MiSeq; Oxford Nanopore MiniION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/16/2024 03:34:28
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,375
            CDSs (total)                      :: 6,221
            Genes (coding)                    :: 5,991
            CDSs (with protein)               :: 5,991
            Genes (RNA)                       :: 154
            rRNAs                             :: 14, 14, 14 (5S, 16S, 23S)
            complete rRNAs                    :: 14, 14, 14 (5S, 16S, 23S)
            tRNAs                             :: 107
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 230
            CDSs (without protein)            :: 230
            Pseudo Genes (ambiguous residues) :: 0 of 230
            Pseudo Genes (frameshifted)       :: 89 of 230
            Pseudo Genes (incomplete)         :: 140 of 230
            Pseudo Genes (internal stop)      :: 70 of 230
            Pseudo Genes (multiple problems)  :: 57 of 230
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 10:27:55
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2492615
            Orig. end                         :: 2517854
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP045606.2.
            On Dec 19, 2019 this sequence version replaced NZ_CP045606.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Steve Petrovski, La Trobe
            University, Bundoora, 3086, VIC, Australia.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..25239
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="betalactone"
                     /region_number="6"
                     /rules="(HMGL-like and AMP-binding)"
                     /tool="antismash"
     cand_cluster    1..25239
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(HMGL-like and AMP-binding)"
                     /kind="single"
                     /product="betalactone"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25239
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:15239](+)"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..15239
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
     gene            294..1220
                     /gene="bla"
                     /locus_tag="GE376_RS12560"
                     /old_locus_tag="GE376_12820"
     CDS             294..1220
                     /EC_number="3.5.2.6"
                     /codon_start=1
                     /gene="bla"
                     /gene_functions="resistance (resist) ClassA"
                     /gene_kind="resistance"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002101021.1"
                     /locus_tag="GE376_RS12560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GE376_12820"
                     /product="class A beta-lactamase Bla1"
                     /protein_id="WP_065486068.1"
                     /transl_table=11
                     /translation="MILKNKKMLKIGICVGILGLSITSLEAFTGGALQVEAKEKTGQVK
                     HKNQATHKEFSQLEKKFDARVGVYAIDTGTNQTISYRSNERFAFASTYKALAAGVLLQQ
                     NSIDTLNEVITFTKEDLVDYSPVTEKHVDTGMKLGEIAEAAVRSSDNTAGNILFNKIGG
                     PKGYEKALRKMGDRVTMSDRFETELNEAIPGDIRDTSTAKAIATNLKAFTVGNALPAEK
                     RKILTEWMKGNATGDKLIRAGVPTDWVVGDKSGAGSYGTRNDIAIVWPPNRAPIIIAIL
                     SSKDEKEATYDNQLIAEATKVIVKALR"
     gene            1481..2323
                     /locus_tag="GE376_RS12565"
                     /old_locus_tag="GE376_12825"
     CDS             1481..2323
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Metallophos_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002141840.1"
                     /locus_tag="GE376_RS12565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GE376_12825"
                     /product="metallophosphoesterase"
                     /protein_id="WP_000727189.1"
                     /sec_met_domain="Metallophos_2 (E-value: 8.3e-08, bitscore:
                     30.8, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKKINRIVMIICILVGFTIFLYLQNNLISITEVKITSSKIPSSF
                     KGYKILQISDLHNKKFGDNQDVLIQKIKSIDPDIIAITGDLIDSKSYDAEVSMQLIREI
                     VKKYPVYFVTGNHEQWSGKYNNLEKELKKYDVNVLRNEHVGIRKGEQEINLLGIDDPEF
                     VTGNRDEGNIIIDEIKKAKIEMQPDKYNVLLSHRPEFIKEYTNERLDLVLSGHAHGGQV
                     RLPFIGGLVAPNQGVLPKYTAGLYVEQNTSMVVSRGLGNSIIPQRILNRPEIVVVQLN"
     gene            2539..2790
                     /locus_tag="GE376_RS12570"
                     /old_locus_tag="GE376_12830"
     CDS             2539..2790
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000548597.1"
                     /locus_tag="GE376_RS12570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GE376_12830"
                     /product="hypothetical protein"
                     /protein_id="WP_000548621.1"
                     /transl_table=11
                     /translation="MHKEYEIEEYTAIEEQIHYYCKCLLVSHPDQIIKYLEKRLEKYAE
                     TLQYAHLYPDTVILPLQQLVIEYSLDVARIRKYMNLKT"
     gene            2979..3704
                     /locus_tag="GE376_RS12575"
                     /old_locus_tag="GE376_12835"
     CDS             2979..3704
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001187059.1"
                     /locus_tag="GE376_RS12575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GE376_12835"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_001187075.1"
                     /transl_table=11
                     /translation="MQQPSIILRTVSKSFGKKEVLHNLSLQVEKAEIFGFVGPSGSGKT
                     TLIKMIAGINEATKGEVLVNNTNMPNLNEMKRIGYMAQADALYEELSAYENADFIATMY
                     GLKGKSKKTRIAEVFELVQLSQYMKKQVQQFSGGMKKRLSLAIALLHEPEILILDEPTV
                     GIDPLLRKTIWEKFYDLKKKGTTIIVTTHIMDEAEFCERLGLIREGKLVAVGTTEELKK
                     RVSSGRIEDVFLLEEVVSS"
     gene            3701..4720
                     /locus_tag="GE376_RS12580"
                     /old_locus_tag="GE376_12840"
     CDS             3701..4720
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1065: ABC-2 type
                     transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002161721.1"
                     /locus_tag="GE376_RS12580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GE376_12840"
                     /product="ABC transporter permease"
                     /protein_id="WP_006928521.1"
                     /transl_table=11
                     /translation="MRVTGVIIRIIRQFFRDKRSLAMMFGAPMLLLWLLSLVFTQKDYI
                     PQIAVVDMPAQIVKVMKNQEASIYEYSKENAISELEKQKVDAILRIENGKMKLLLEGSD
                     SSKNRAVLQVLQKSTEKNDVSIMKPEVNYLHGSKDFTMFDGLGPVLIGFFTFFFVFILS
                     GVSFVRERLSGTLERLLSTPVRRWEIVAGYIIGFGIFAFIQSIIIVSFSVYILDLYVAG
                     SIWLTLLITCMLSLTALTLGTFLSAYANNEFQMIQFIPLVIVPQIFFSGLFPMESMNKW
                     LQMLGKVFPLTYGADAMRQVMIRNQGFTEIALDLTVLLLFSLLFAVGNVFALKKHRKI"
     gene            4745..5398
                     /locus_tag="GE376_RS12585"
                     /old_locus_tag="GE376_12845"
     CDS             4745..5398
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001168191.1"
                     /locus_tag="GE376_RS12585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GE376_12845"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_065483689.1"
                     /transl_table=11
                     /translation="MQKDWLEELIAATNTDKKNERQMRILEAAVDMFGEKGYASTSTSE
                     IAKRAGVAEGTIFRYYKTKKDLLLAVVMPTLTKFAAPFFVQTFAKEIFKSEYESYERLL
                     RVVIHNRFKFAQKHFPMIKILIQEVPFQPELKNEIQQLVETELFSHFKKLIVKFQEEGE
                     IIEIPPSSVLRLTLSAVLGLLLTRFLLLPEEKWNDEAEIENTIQFILYGLTPRF"
     gene            complement(5520..5819)
                     /locus_tag="GE376_RS12590"
                     /old_locus_tag="GE376_12850"
     CDS             complement(5520..5819)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000728146.1"
                     /locus_tag="GE376_RS12590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GE376_12850"
                     /product="WGxxGxxG family protein"
                     /protein_id="WP_000728157.1"
                     /transl_table=11
                     /translation="MKKKLSSILSVLALSIMFLGTSTQAEYDGNNMNRVNNTDISTRVN
                     DNNLDRVNNDVRTRNVNTTNDLNDNRDKNNNWAWLGLLGLAGLLGLRRRDKETR"
     gene            6053..7021
                     /locus_tag="GE376_RS12595"
                     /old_locus_tag="GE376_12855"
     CDS             6053..7021
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001248633.1"
                     /locus_tag="GE376_RS12595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GE376_12855"
                     /product="DUF523 and DUF1722 domain-containing protein"
                     /protein_id="WP_044306560.1"
                     /transl_table=11
                     /translation="MRQFAKPTIVVSKCLEFDACRYNGEMIPDVTIRNLQPFVTFIPVC
                     PEVEIGLGTPRETIRIVEENGENRLVQPSTREDVTEKMEQFSNDFLQTIPDVDGFILKN
                     RSPSCGTRDVKIYSGFEKAPAKGKGSGLFGGAVVKKFSHLPIEEEGRLSNFIIREHFFT
                     RLFTIAYYKMIKHSKNIKDLVSFQSDNKYLFMAYNQVKQKELGRIIANQKNEKIEVVFE
                     NYEKTLYELFMRAPRYTSNVNVCEHIFGYFKTKLKKQEKDHFIELLQKYAEKKIPLSSL
                     LTILKSWAIRFDEKYLLRQTYFEPYPEALVEISDSGKGRDY"
     gene            7238..8383
                     /locus_tag="GE376_RS12600"
                     /old_locus_tag="GE376_12860"
     CDS             7238..8383
                     /EC_number="1.3.99.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001980414.1"
                     /locus_tag="GE376_RS12600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GE376_12860"
                     /product="acyl-CoA dehydrogenase"
                     /protein_id="WP_000397279.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 1.8e-39, bitscore:
                     133.2, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 5.6e-26, bitscore:
                     88.9, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 7.4e-57, bitscore:
                     190.1, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEFTLTREKQMIKEMVRDFAEKEIAPKAVYYDKTAEFPYETFQKM
                     GELGLLGIPFPEEYGGSGGDTVSYALAVEEIGRACGGTGLSYAATISLGASPIYYFGTE
                     EQKQKYLVPMASGKTLGAFGLTEPNAGSDAGGTQTKAVLDGDEYVISGEKCWITNAEYA
                     NTIIVTAVNGIEENGRKRISAFIVPTTSEGLTISSPYDKMGVRASNTCEIVLDGVRVPK
                     ENILGDVNKGFKQFLYTLDGGRISIAALAVGIAQSAFERALQYAKERQQFGKSISNFQA
                     IQFKLADMATEVELARNLVHKAAWLKDNDKPFGKEAAMAKLFASEAASRIANQAVQIHG
                     GYGYMREYEVERHIRDAKLLEIGEGTSEIQRLVIARHLGCR"
     gene            8399..9736
                     /locus_tag="GE376_RS12605"
                     /old_locus_tag="GE376_12865"
     CDS             8399..9736
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dala_Dala_lig_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RimK"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1090: acetyl-CoA carboxylase biotin carboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000486723.1"
                     /locus_tag="GE376_RS12605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GE376_12865"
                     /product="acetyl-CoA carboxylase biotin carboxylase
                     subunit"
                     /protein_id="WP_000486742.1"
                     /sec_met_domain="Dala_Dala_lig_C (E-value: 2.7e-10,
                     bitscore: 38.4, seeds: 12, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp_3 (E-value: 3.6e-06, bitscore:
                     25.4, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="RimK (E-value: 3e-06, bitscore: 25.3,
                     seeds: 4, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp (E-value: 4.7e-09, bitscore:
                     34.3, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFQKILIANRGEIAVRIMKTCQKLGIRTVAIYSEADENALHVKMA
                     NEAYLVGGPRVQESYLNLEKIIEIAKKTNAEAIHPGYGLLSENPSFPVRCKEEGIVFIG
                     PSEEIITKMGSKIESRIAMQAADVPVVPGITTNIETAEEAIEIAKQIGYPLMLKASAGG
                     GGIGMQLMETEQTLTKAFESNKTRAQNFFGNGEMYLERYIADAHHIEIQLLADTHGNTV
                     YLWERECSVQRRNQKVIEEAPSPFLDEGTRKAMGEVAVQAAKALGYTNAGTVEFLVDDQ
                     KNFYFLEMNTRLQVEHPVTEEITGLDLVEQQLLIASGEKLSFTQDDVKRSGHAIEARIY
                     AEDPKTFFPSPGKITDLTLPSNVRIDHFLENHVTITPFYDPMIAKVIAHGETREEAISK
                     LHDALEELKVEGIKTNTPMLLQVLEDEVFKEGIYTTGFVTKQLVKK"
     gene            9764..9979
                     /locus_tag="GE376_RS12610"
                     /old_locus_tag="GE376_12870"
     CDS             9764..9979
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001987345.1"
                     /locus_tag="GE376_RS12610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GE376_12870"
                     /product="acetyl-CoA carboxylase biotin carboxyl carrier
                     protein subunit"
                     /protein_id="WP_001987345.1"
                     /transl_table=11
                     /translation="MMTKVYASMAGNVWKIVVGVGDTVEEEQDVVILESMKMEIPIISE
                     EAGTVMKINVQEGDFVNEGDVLLEIE"
     gene            10001..10912
                     /gene="mvaB"
                     /locus_tag="GE376_RS12615"
                     /old_locus_tag="GE376_12875"
     CDS             10001..10912
                     /EC_number="4.1.3.4"
                     /codon_start=1
                     /gene="mvaB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: HMGL-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1271: 2-isopropylmalate synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017149491.1"
                     /locus_tag="GE376_RS12615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GE376_12875"
                     /product="hydroxymethylglutaryl-CoA lyase"
                     /protein_id="WP_000775435.1"
                     /sec_met_domain="HMGL-like (E-value: 2.3e-47, bitscore:
                     160.1, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLPNFAVIKEVGPRDGLQNEKKIVGTKDKVKWIQLLTEAGLSYV
                     EVSSFVHPKWVPALADANDVFSELKRDPNVTYAALVPNQNGLERAFLQNVDEVNVFLSA
                     SESHNKSNINKSIKEALVVIEDITKQALFEGKKVRGYVSTVFGCPYEGDISVTAVDELC
                     NQLFSYGIYEVSLGDTIGVANPLQVEQVLEHLLKKYDASQFAMHFHNTYGMALANVVKS
                     LEYGIKTFDSSCGGLGGCPYAPGASGNVATDDLVHMLHKLGVQTNIDEEKLLRASQFIQ
                     SKLNIQLPSHVYRALQHKTISR"
     gene            10917..11705
                     /locus_tag="GE376_RS12620"
                     /old_locus_tag="GE376_12880"
     CDS             10917..11705
                     /EC_number="4.2.1.17"
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: ECH (14-254). E-value: 9.4e-75. Score:
                     243.0. Matches aSDomain:
                     nrpspksdomains_GE376_RS12620_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001990763.1"
                     /locus_tag="GE376_RS12620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GE376_12880"
                     /product="enoyl-CoA hydratase"
                     /protein_id="WP_153217873.1"
                     /transl_table=11
                     /translation="MLQLQNISVDYVTPHVVKISLNRARQVNSLSLALLDELQTILTQI
                     SEDSNARVVILTGAGEKVFCAGADLKERADMNEEQVRHAVSMIRTTMEMVEQLPQPVIA
                     AINGIALGGGTELSLACDFRIAAECASLGLTETTLAIIPGAGGTQRLPRLIGVGRAKEL
                     IYTGRRISAQEAKEYGLVEFVVPANLLEEKAIEIAEKIASNGPIAVRLAKEAISNGIQV
                     DLHTGLQMEKQAYEGVIHTKDRLEGLQAFKEKRTPTYKGE"
     aSDomain        10959..11678
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_GE376_RS12620_ECH.1"
                     /evalue="9.40E-75"
                     /label="GE376_RS12620_ECH.1"
                     /locus_tag="GE376_RS12620"
                     /protein_end="254"
                     /protein_start="14"
                     /score="243.0"
                     /tool="antismash"
                     /translation="HVVKISLNRARQVNSLSLALLDELQTILTQISEDSNARVVILTGA
                     GEKVFCAGADLKERADMNEEQVRHAVSMIRTTMEMVEQLPQPVIAAINGIALGGGTELS
                     LACDFRIAAECASLGLTETTLAIIPGAGGTQRLPRLIGVGRAKELIYTGRRISAQEAKE
                     YGLVEFVVPANLLEEKAIEIAEKIASNGPIAVRLAKEAISNGIQVDLHTGLQMEKQAYE
                     GVIHTKDRLEGLQAFKEK"
     gene            11708..13249
                     /locus_tag="GE376_RS12625"
                     /old_locus_tag="GE376_12885"
     CDS             11708..13249
                     /EC_number="6.-.-.-"
                     /GO_function="GO:0016874 - ligase activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_389703.2"
                     /locus_tag="GE376_RS12625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GE376_12885"
                     /product="acyl-CoA carboxylase subunit beta"
                     /protein_id="WP_000886758.1"
                     /transl_table=11
                     /translation="MLDQKQQSNTFEERVETIKQGGAPKYHEQNRAKGKLFVRDRLALL
                     FDNGEYVEDALFANCEQTGLPADGVVTATGKIHGRTACVMANDSTVKAGSWGSRTVEKI
                     LRIQETAEKLRVPLFYLVDSAGARITDQVEMFPGRRGAGRIFYNQVKLSGKVPQVCLLF
                     GPSAAGGAYIPAFCDVVMMVEGNASMYLGSPRMAEMVIGEKVTLEEMGGARMHCSVSGC
                     GDVLCKTEEDAITQARQYISYFPNNYLEKTPLVTPQEPKQFDKTLEQIIPENQNAPFNM
                     KDLINRVIDEGSFYEVKKLFAQELITGLARIDGKPVGIIANQPRMKGGVLFHDSADKAA
                     KFINLCDAYHIPLLFLADVPGFMIGTKVERAGIIRHGAKMISAMSEATVPKISIVVRKA
                     YGAGLYAMAGPAFEPDCCLALPTASIAVMGPEAAVNAVYANKIAALPEEERASFIAEKR
                     EEYKKDIDIYHLASEMVIDGIVHPNNLREELKGRFEMYMSKYQVFTDRKHPVYPV"
     gene            13299..15239
                     /locus_tag="GE376_RS12630"
                     /old_locus_tag="GE376_12890"
     CDS             13299..15239
                     /NRPS_PKS="Domain: AMP-binding (99-521). E-value: 2.8e-82.
                     Score: 268.4. Matches aSDomain:
                     nrpspksdomains_GE376_RS12630_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017560287.1"
                     /locus_tag="GE376_RS12630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GE376_12890"
                     /product="AMP-binding protein"
                     /protein_id="WP_153217876.1"
                     /sec_met_domain="AMP-binding (E-value: 7.9e-88, bitscore:
                     293.1, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQAVWFPTEEYKEKTRLYGWMKSLGYEDYETFYNKSIEETAWFW
                     GEAEKAVGYQWMKPYTEVLDLENGTPFAQWYNGGTCNVVESALSRWLADEETRIQPALQ
                     YEGENGTSKSFTYEELDNWVSRVANGLKHAGIEKGDRVTIYMPMIPETVVAMLAVMKIG
                     AIISPIFSGFASDAVMTRVQAAGSKMIITADGFSRRGKIVSLKDEVDKACEHCPTVEKV
                     VIVRHAGNDFTPHNYDFSWSTLEKEKPFIHAEKMQSDDPLMLIYTSGTTGKPKGTVHTH
                     AGFPLKAAFDAGFGMNIKQGDRVLWVTDMGWMMGPFLLFGSLINGATMVMYEGVPDFPE
                     ADRLWETVDKYEITHLGISPTLIRALMAKGDEYVNKHSLKSLEVFASTGEPWNPDPWMW
                     LFETVGKGNVPICNYSGGTEISGGIFGNVLIKPIAPISFNASLPGMAAVVLDDQGKPIQ
                     DEVGELCLEKPWVGMTKSFWEDDERYVNTYWSRFENKWVHGDWVIYDGEQYIITGRSDD
                     TLNIAGKRIGPAEYESILVKHNDVIEAAAIGVPDEVKGEVCHCFVVLRDHVTFTGELKK
                     ELMSLVNSHIGKALCPKDIHVVEDLPKTRNSKVMRRVIKAAYLGKELGDLSSLVNPEVV
                     PFIQGLQSSKL"
     aSDomain        13596..14861
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_GE376_RS12630_AMP-binding.1"
                     /evalue="2.80E-82"
                     /label="GE376_RS12630_AMP-binding.1"
                     /locus_tag="GE376_RS12630"
                     /protein_end="521"
                     /protein_start="99"
                     /score="268.4"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="QPALQYEGENGTSKSFTYEELDNWVSRVANGLKHAGIEKGDRVTI
                     YMPMIPETVVAMLAVMKIGAIISPIFSGFASDAVMTRVQAAGSKMIITADGFSRRGKIV
                     SLKDEVDKACEHCPTVEKVVIVRHAGNDFTPHNYDFSWSTLEKEKPFIHAEKMQSDDPL
                     MLIYTSGTTGKPKGTVHTHAGFPLKAAFDAGFGMNIKQGDRVLWVTDMGWMMGPFLLFG
                     SLINGATMVMYEGVPDFPEADRLWETVDKYEITHLGISPTLIRALMAKGDEYVNKHSLK
                     SLEVFASTGEPWNPDPWMWLFETVGKGNVPICNYSGGTEISGGIFGNVLIKPIAPISFN
                     ASLPGMAAVVLDDQGKPIQDEVGELCLEKPWVGMTKSFWEDDERYVNTYWSRFENKWVH
                     GDWVIYDGEQYIITGRSDDTLNI"
     CDS_motif       14085..14141
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_GE376_RS12630_0001"
                     /evalue="7.60E-08"
                     /label="NRPS-A_a3"
                     /locus_tag="GE376_RS12630"
                     /protein_end="281"
                     /protein_start="262"
                     /score="24.7"
                     /tool="antismash"
                     /translation="MLIYTSGTTGKPKGTVHTH"
     CDS_motif       14832..14894
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_GE376_RS12630_0002"
                     /evalue="7.80E-04"
                     /label="NRPS-A_a8"
                     /locus_tag="GE376_RS12630"
                     /protein_end="532"
                     /protein_start="511"
                     /score="12.3"
                     /tool="antismash"
                     /translation="TGRSDDTLNIAGKRIGPAEYE"
     gene            complement(15561..15965)
                     /locus_tag="GE376_RS12635"
                     /old_locus_tag="GE376_12895"
     CDS             complement(15561..15965)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="GE376_RS12635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GE376_12895"
                     /product="hypothetical protein"
                     /protein_id="WP_000560140.1"
                     /transl_table=11
                     /translation="MIAGVLRKSIVVMIGGNLKKSIIVMMIGVLRKSIVMMIGGNLKKS
                     VIVMTIGVLRKNIVMMIGGNLKKSVIVMMIGVLNEISVVVNVSLFVAIVKEKIGNIFNV
                     NVKEKICLLESIGLFRKVDPSPTSLLSLNF"
     gene            16562..16918
                     /locus_tag="GE376_RS12640"
                     /old_locus_tag="GE376_12900"
     CDS             16562..16918
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000535569.1"
                     /locus_tag="GE376_RS12640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GE376_12900"
                     /product="hypothetical protein"
                     /protein_id="WP_000535577.1"
                     /transl_table=11
                     /translation="MGSRFNNCKKKCTCKQDDCWEVFEECKKEQHEKCDNSCVQGIRDE
                     LKKLINRTVQINTEGRTYVGTVSSVSCDVVRLAAIPGSVGVIISICKIEAIFPPVTTVT
                     ADFDFNGIDVANKA"
     misc_feature    16933..16948
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: strong, score: 18.06"
                     /tool="antismash"
     gene            17024..17557
                     /locus_tag="GE376_RS12645"
                     /old_locus_tag="GE376_12905"
     CDS             17024..17557
                     /EC_number="2.-.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111: GCN5-related N-acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002007691.1"
                     /locus_tag="GE376_RS12645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GE376_12905"
                     /product="GNAT family protein"
                     /protein_id="WP_000990089.1"
                     /transl_table=11
                     /translation="MMYERSMEVIKLKTFKKSDFKQLINWINSEEFLIQWSGNAFTFPL
                     DEQQLEKYIESANTLAFKVVDEETSDVIGHISLGQIDNINKSARIGKVLVGNTKMRGRS
                     IGKHMMKAVLHIAFDELKLHRVTLGVYDFNISAISCYEKIGFVKEGLLRESKRVGETYW
                     NLWEMSMLEYEWKK"
     gene            complement(17828..18436)
                     /locus_tag="GE376_RS12650"
                     /old_locus_tag="GE376_12910"
     CDS             complement(17828..18436)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000807974.1"
                     /locus_tag="GE376_RS12650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GE376_12910"
                     /product="hypothetical protein"
                     /protein_id="WP_153217878.1"
                     /transl_table=11
                     /translation="MAEIKVGLTQFLDFTLKGSTAKTTFIKNLKSQPEYQPAFDYWKQL
                     RETVIKFHQNKLPFEYFETLVQTVDQKKKQNYIDVIKQYKKFIKNKDISWFDPGKSHWK
                     SDDLIVRSSPELGLFINNEPHLIKLFFKGKKERIDKYNINSTLTLLNESTFSNERNDVN
                     YTVLNIQKNRMYTNNSINNNHLVALKSEANQFCYIWNNL"
     misc_feature    18587..18603
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: medium, score: 21.51"
                     /tool="antismash"
     misc_feature    19043..19059
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 24.65"
                     /tool="antismash"
     gene            complement(19150..19287)
                     /locus_tag="GE376_RS12655"
                     /old_locus_tag="GE376_12915"
     CDS             complement(19150..19287)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000376553.1"
                     /locus_tag="GE376_RS12655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GE376_12915"
                     /product="DUF3956 domain-containing protein"
                     /protein_id="WP_000376554.1"
                     /transl_table=11
                     /translation="MDSCVVFVNGQPFLVLSVAGIEIARLEISLQVALALRVLGIPICD
                     "
     misc_feature    complement(19440..19449)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 18.57"
                     /tool="antismash"
     gene            <19453..19563
                     /locus_tag="GE376_RS12660"
                     /old_locus_tag="GE376_12920"
                     /pseudo=""
     CDS             <19453..19563
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000288863.1"
                     /locus_tag="GE376_RS12660"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="GE376_12920"
                     /product="DinB family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="VLRHVIVHEIHHIGQLSIWARELNLQPVSANLIGRG"
     gene            complement(19625..20641)
                     /locus_tag="GE376_RS12665"
                     /old_locus_tag="GE376_12925"
     CDS             complement(19625..20641)
                     /EC_number="3.4.-.-"
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001160038.1"
                     /locus_tag="GE376_RS12665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GE376_12925"
                     /product="D-alanyl-D-alanine carboxypeptidase family
                     protein"
                     /protein_id="WP_065483697.1"
                     /transl_table=11
                     /translation="MQFLKKFAILLLSFFITALIVLYFYLYVNGPIIQAKSAILINANS
                     GEIVYKKNEETPVQSATLSKLMTEYIVLEQLNDRKIQLDDFVQISNEVFRVETSPIQVT
                     SNDKTTVRDLLHALLLAGNNRSALALAEHIAGTEDNFTILMNKKAKELQLLQPSPFLNS
                     TGINHDTNKQSTTTAIDAAKLAAQLVKDFPDVLNITKLTSYQFTFKDSQVFNTNKMIYS
                     LNENIKLQGVDGLQTSFSTNGNYSFVSTAKLGDTRLISVILDADEENISFIETKKLLQY
                     GFDPSSYSALQAFKDTLTSWTILLQFKNLIIQTIMIFLIITTLMFLHIRQKKSEDFN"
     gene            complement(20817..21974)
                     /locus_tag="GE376_RS12670"
                     /old_locus_tag="GE376_12930"
     CDS             complement(20817..21974)
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="resistance (resist) vanS"
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016129473.1"
                     /locus_tag="GE376_RS12670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GE376_12930"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_001243312.1"
                     /transl_table=11
                     /translation="MRNEAFDILKDIPKWKLIFWLLLAITLTPITELIIYRLVTSVIES
                     SLTLTELGKEFIRIFGYEKYKGIKESLWMMIVSYLFLFSIFSSYLYIFYRHEKKLYYET
                     CIKKMIEEIRYIANGNFNHKVSIVNHNYLEELAIGVNEIVEQLKVSIDEERQAEQAKSE
                     LITNVSHDLRTPLTSIVGYVNLIHHDNYRDEVELRYYIQVIYDKVTRLNALMNDLFEYT
                     RVQNKELSLYSVPIDIVELLGQLTVQFRIQVQEANIECRPSFPSQKLMVLADGDKLVRV
                     FENLIINAIAYGSEGRYIDLTAYESNNMITIDITNYGQPIPSTDLPHIFERFYRVEKSR
                     STNTGGSGLGLAIAKSIVELHKGTIEVYSDDEKTTFTVKLLPYKC"
     gene            complement(21964..22659)
                     /locus_tag="GE376_RS12675"
                     /old_locus_tag="GE376_12935"
     CDS             complement(21964..22659)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="resistance (resist) vanR"
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001038809.1"
                     /locus_tag="GE376_RS12675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GE376_12935"
                     /product="response regulator transcription factor"
                     /protein_id="WP_001038809.1"
                     /transl_table=11
                     /translation="MNKNILIIDDDKEIVELLAVYLRNEGYNIYKAYDGDEALQKVSTY
                     EVDLMILDIMMPKRNGLEVCQEVRENNTVPILMLSAKAEDMDKILGLMTGADDYMIKPF
                     NPLELVARVKALLRRSSFQNATSQKNEDGIIRIRSVEIHKHNHTVKVNGEYIKLTSIEF
                     DILYLLASNTGRVFSSEEIFERVWNEDGYGSNKTVMVHISNLRDKLETVMNGEKLIHTV
                     WGVGYKIEK"
     gene            22852..23460
                     /gene="yqeK"
                     /locus_tag="GE376_RS12680"
                     /old_locus_tag="GE376_12940"
     CDS             22852..23460
                     /EC_number="3.6.1.41"
                     /codon_start=1
                     /gene="yqeK"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000965880.1"
                     /locus_tag="GE376_RS12680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GE376_12940"
                     /product="bis(5'-nucleosyl)-tetraphosphatase (symmetrical)
                     YqeK"
                     /protein_id="WP_153217880.1"
                     /transl_table=11
                     /translation="MLCNDIYLFTPTGKIDNDIKVFLLKYNKEFTYKHSIRVANEAKKI
                     AEKFHVDKEKAAIAGYLHDISGIFPNEERIAVAEEFGVEIVETERKIPMIIHQKLSRVI
                     AKEIFKVEDEEILNAICCHTTLRKHATKMDLVLFVADKIEWDQNGTPPYLIEIKKGLEK
                     SLEKAAFVYISYLWERKDTLKVIHPWLEEAYWDLKGILQ"
     gene            23474..24148
                     /locus_tag="GE376_RS12685"
                     /old_locus_tag="GE376_12945"
     CDS             23474..24148
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002156408.1"
                     /locus_tag="GE376_RS12685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GE376_12945"
                     /product="DUF3885 domain-containing protein"
                     /protein_id="WP_043924663.1"
                     /transl_table=11
                     /translation="MQLKEYMNQTFPGVTLGPYLYSQWGNHLHFDFGKDKYQIVEGTND
                     LNMEYFSQLYTYNKFLFEDIFSKEDVVFVVTNVYRFKKENIKTPQKINVYNKYIKKRDL
                     RFHIRQETLPFLFEDEEADLYCTYHFSLKCLAEDIKYELLIQAANHEDFSALYPRFGRK
                     KEISYPDVFLINATKDIVMFMCDDRGCEVIAKNKEIIRDLYKKYKEWIPDYERESIDNL
                     FK"
     gene            24145..24882
                     /locus_tag="GE376_RS12690"
                     /old_locus_tag="GE376_12950"
     CDS             24145..24882
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016129475.1"
                     /locus_tag="GE376_RS12690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GE376_12950"
                     /product="S-adenosylhomocysteine nucleosidase"
                     /protein_id="WP_065483699.1"
                     /transl_table=11
                     /translation="MTIGEVKRVMKRIAIVSAWEPELTYLHQHYPSERVEKRAAWEFHF
                     HTIYELEIISVVTGVGKVSCASCVQLLISEFQPDELFMTGICGSLSNKVKNGHIVVALN
                     AIQHDVTAAGSGEDVFNLYNGRTAPIETTKSLVRRIKKIRSYDPIHFGTFLSGDQRIRS
                     SEMRYLLHTVYGALAVDQEVAAFAYVCQINKKPFLCLKAASDQANDKTKEEQKIFKMLA
                     CERACEHLIAFLRVYEINVVNNR"
ORIGIN
        1 agatgtatac tttgatttaa aacagcaacg tatacatggt gaagctacta gtacaggtag
       61 ttctaagcaa aattagagta cttttctcag ggaaagaccc tgttcatata aagccattta
      121 taagtaaaaa aatgaaatat gaaataagag atagaggcgt cgtagctact atctcttatt
      181 ttgttaataa ctctcatact agctataatt tttttagttt atggaacaaa ctcgtttcgc
      241 tgattgtcta ttatgtgtac gtataaatag gtgttaagaa tttgaaagga atgatgattt
      301 tgaaaaacaa gaagatgcta aaaataggaa tatgcgttgg tatattaggt ttaagtatta
      361 caagcctaga agcttttaca ggaggggcac tgcaagttga agcgaaagaa aagactggac
      421 aagtgaaaca taaaaatcag gcgacgcata aagagttctc tcaacttgag aaaaaatttg
      481 atgctcgagt aggtgtatat gcgattgata ctggtacaaa tcaaacaatt tcttatcgat
      541 ctaacgaaag atttgccttc gcatcaacct acaaggcttt agcagcagga gtattactac
      601 agcaaaactc aattgataca ttaaatgaag taatcacatt tacgaaagaa gacttagtgg
      661 attattcacc tgttacagag aaacatgtag atactggaat gaaactagga gaaattgctg
      721 aggctgctgt tcgttcaagt gataatactg cagggaacat tttatttaat aaaataggcg
      781 gacctaaagg atatgaaaaa gcgcttagaa agatggggga tcgggttact atgtctgatc
      841 gctttgaaac agaattaaac gaagctattc caggagacat tcgtgacact agtacagcga
      901 aagcaattgc tacgaatctt aaagctttta cggtcggaaa tgcacttcca gctgaaaaac
      961 gtaaaattct tacagagtgg atgaaaggaa atgctacagg ggacaaactt attcgtgcag
     1021 gcgtaccaac tgactgggta gttggagata aatcaggtgc tggcagttac gggacaagaa
     1081 atgatattgc tatcgtttgg cctccgaata gagcaccaat tatcatcgca attttatcta
     1141 gtaaagatga gaaagaggca acctatgata atcaactcat tgcagaggca actaaagtta
     1201 tagttaaggc tcttaggtaa tagtatttta gttttcgcat ttttaacatg aaagtattaa
     1261 aagtataaag ttagaaaacg actcttttcg tgtgataaga gtcgtttttg tattcttatt
     1321 attaaaaagg taaaagtaaa aatataacga atatatatga catatctcat atgaaatttc
     1381 atgtactgta ttattttatt aatttaaata aatttcaaga aagtataata taattcagtt
     1441 agcatataga agtgtttgat gagaatgtaa aggagaaaat atgaaaaaga agattaatag
     1501 aattgtaatg attatttgta tattagtagg ttttacaatc tttttatatt tacagaacaa
     1561 tttaataagt ataactgagg ttaaaataac ctctagtaaa ataccatcct cttttaaagg
     1621 gtataaaatt ctacaaattt cagacttaca caataaaaaa tttggcgata atcaagatgt
     1681 gttaattcaa aaaataaaaa gtatagaccc agatattatt gcgattacgg gtgatttaat
     1741 tgacagtaaa tcatacgatg cagaagttag tatgcaatta atacgagaaa ttgtaaagaa
     1801 atatcctgta tattttgtga caggaaacca tgaacaatgg tctggaaagt ataacaattt
     1861 agaaaaagag ttgaagaaat atgatgtcaa tgttttaagg aatgaacatg taggcattcg
     1921 aaagggtgag caagaaataa acttgctagg tattgatgat ccagagtttg ttactggaaa
     1981 ccgtgatgaa ggaaatatta taatagatga aattaaaaaa gcgaaaattg aaatgcagcc
     2041 agataaatat aatgtattat tatcccatcg gcctgaattt ataaaggaat atacgaatga
     2101 gaggttggat ttggttttat cgggacatgc tcatggaggg caagttagat tgccatttat
     2161 cggaggatta gttgcgccaa atcaaggtgt tttacctaaa tatacagcgg gtttatatgt
     2221 agaacaaaat acatcaatgg tagtgagtag aggattagga aatagtatca ttccgcaaag
     2281 gattttgaat aggccagaaa ttgtagtcgt gcagctaaat taagctgtac gatttttttt
     2341 atacaaaaat gagtaaaggg gctttctgta ttttgcagga gtaaacatta caattttgtt
     2401 aaaaattttc tacgttacat aaagtaacaa aatttgaccc tcagtgtttg ttatagtgta
     2461 aataatcaaa aaacttaaaa tttgtcgagt gaaaattgtg ataagtaatt catataaaaa
     2521 acttaaaggg gtgtacacat gcataaagaa tatgaaattg aagaatacac ggcgattgag
     2581 gaacaaatcc attattattg taaatgttta ttagtaagtc atcctgatca aataataaag
     2641 tatttagaaa aaaggttaga aaaatatgca gaaacattac aatatgcaca tttatatcct
     2701 gacacagtta ttttaccgtt acagcaatta gttatcgaat attctttaga cgttgctaga
     2761 attcggaagt atatgaattt aaaaacgtaa agtgaaattt atagtttaaa tgaaacagag
     2821 tcgactttag gaaatgaaat gctaatgtcg actctgtttc attgtttaat atcggtgatt
     2881 gaacatacat actaatcaac gaagtttgac atataattaa gcaagagtaa aataaaagtg
     2941 agtactcact catttttatt ggaaaaggag gatgaaacgt gcaacaacct tcaattattt
     3001 tacggactgt atcaaaaagt tttggaaaaa aagaagtgtt acacaatctt tcattgcaag
     3061 ttgaaaaagc agagattttt ggttttgttg gaccttctgg atcggggaaa acaacgctca
     3121 ttaaaatgat tgcaggtatt aatgaggcaa cgaaaggtga agtgcttgtt aataatacta
     3181 atatgcctaa tttaaatgaa atgaaacgaa ttggttatat ggcccaggcg gatgcattat
     3241 atgaagaatt gtcagcatat gaaaatgcag attttatagc aacgatgtat ggattaaagg
     3301 gaaaaagtaa aaagacaaga attgcagagg tttttgaact tgtacaattg tcacagtata
     3361 tgaaaaagca agtacaacaa ttttcaggtg gaatgaaaaa acgcttatca ttagcaatag
     3421 cactcctcca tgaaccagaa atattaattt tagatgagcc tacagtgggg atagatccgc
     3481 ttcttagaaa aacgatttgg gaaaaatttt atgatcttaa aaagaaaggc acaacgatta
     3541 ttgtaacgac gcacattatg gatgaagctg aattttgtga gcgtctaggg ttaattagag
     3601 aagggaaact agttgcggtt ggaacaactg aagaattgaa aaaacgcgtg tcatctggac
     3661 ggattgaaga tgtctttttg ttggaagagg tggtgtcatc atgagagtta ctggtgtaat
     3721 cattcgtatt attcgccaat tttttcgaga taagcgttcg ttagcgatga tgtttggggc
     3781 accaatgtta ttactttggc tattatcgct agtgtttaca caaaaagact atataccgca
     3841 aattgctgtt gttgatatgc ccgctcaaat agtaaaagtg atgaaaaatc aagaagcgtc
     3901 aatttatgaa tacagtaaag aaaacgcgat ttctgagtta gaaaaacaaa aggtagatgc
     3961 aatacttcga atagagaatg gaaaaatgaa acttctgttg gaaggtagtg attcgtcaaa
     4021 aaatcgtgct gtacttcaag tattgcaaaa aagcacagag aagaatgatg tatcgattat
     4081 gaaacctgaa gtaaattatt tacatggctc taaagacttt acgatgtttg atgggcttgg
     4141 tcctgtatta attggtttct ttacattttt ctttgtattt atattatcag gtgtatcttt
     4201 cgtaagagaa cgtttaagtg gtacgctaga aaggttatta tccaccccag taagaagatg
     4261 ggaaatagtc gcaggttata ttattggttt tggaatcttt gcctttatac aatccattat
     4321 tatcgtaagt ttttccgttt atattttaga tttatacgta gctggctcca tatggctaac
     4381 gttacttatt acatgtatgc tctctttaac tgcactaaca ttaggtacgt ttttatcggc
     4441 atacgcaaat aatgaatttc aaatgattca atttataccg cttgttattg tgccacaaat
     4501 cttcttttct ggattgtttc caatggaatc tatgaataag tggctacaaa tgttagggaa
     4561 agtatttcca ctcacatacg gcgctgacgc aatgagacaa gtgatgattc ggaatcaagg
     4621 gtttacagag attgcattag atcttactgt attattactt ttttcactat tatttgcagt
     4681 aggaaatgta tttgctttaa agaaacatcg caaaatataa taatgacaaa aaggagcttt
     4741 ataaatgcag aaggattggc tggaggaatt aatagctgca actaatacgg ataaaaaaaa
     4801 tgaacgtcaa atgcgaatat tagaggcggc tgttgatatg tttggagaaa aaggatacgc
     4861 ttcaacttca acaagtgaaa ttgcaaaacg ggctggtgta gcggaaggaa caatcttccg
     4921 ctactataag acgaaaaaag atttattact agcggtcgta atgccaactt taactaagtt
     4981 cgctgcacca tttttcgtac aaacctttgc aaaagaaata tttaaatcgg agtatgaatc
     5041 atatgaaaga cttttaaggg ttgtaattca taataggttt aaatttgctc aaaaacactt
     5101 tcctatgata aaaatattaa ttcaagaggt gccattccaa ccagaactga aaaatgaaat
     5161 acagcaatta gtagaaacag aactgttttc acatttcaaa aagttgattg tgaaatttca
     5221 agaagaaggg gaaattattg agataccacc atcttccgta ctacgtctta ctttatcagc
     5281 tgtattaggt ttattattaa cacgattttt attattgcct gaagaaaaat ggaatgatga
     5341 agcggaaatt gaaaatacga ttcaatttat attgtatgga ttaactccac gattttaatc
     5401 gttgaagtgt gaattacata cattactttt aagtaaaaat aaatcgcctt taaaaaggcg
     5461 atttattttc attatatatt tttgataaat aagtacttgt ttactaaaaa cattctaaat
     5521 cagcgtgttt ctttgtctct tcttctaaga cctaataatc ctgctagtcc taataaacca
     5581 agccaagccc aattattatt tttatcacga ttatcattta aatcatttgt tgtatttaca
     5641 tttcgagttc ttacatcatt attaactctg tctaagttat tgtcatttac tcgagttgaa
     5701 atatcagtgt tattaactct attcatatta tttccatcgt attcagcttg cgtagatgta
     5761 cctaaaaaca taatagatag tgctaaaaca cttaaaatag atgataattt ctttttcata
     5821 acaatccctc ctttcttaat cattaatttc tccgaagcaa gtgtgtatta ttcatttcac
     5881 aatatctaaa ccctcattaa taaggcgcac atttatagaa aatagagttg aatgattgtt
     5941 aatatatcat tggatatata tttctcataa aaataaatga atcaaacttt gcttaaaatg
     6001 ttaatcttag tacaatttat attatacggg ctagcactaa ggaggtaata agatgcgaca
     6061 atttgcaaaa ccaacaatcg tcgtaagtaa atgtttagaa tttgatgctt gtcgttataa
     6121 tggagagatg attccagatg taacaatacg aaatttgcag ccatttgtta catttatacc
     6181 tgtttgtcca gaagtcgaga ttggattggg gactcctcgt gaaacgatac gaattgtaga
     6241 agaaaatggt gagaatagac ttgtgcaacc gtcgacacga gaagatgtaa ctgaaaaaat
     6301 ggagcagttt tcaaatgact ttttacaaac gataccggat gtggatggtt ttattttaaa
     6361 gaatcgttca ccaagttgtg gtacgcgtga tgtgaaaatt tattctggtt ttgaaaaagc
     6421 gccagcaaag ggaaaaggat cgggcttatt tggcggagca gtagtaaaaa aattttcgca
     6481 tcttcctatt gaagaggaag gcagattgtc gaattttatt attagagagc atttctttac
     6541 aaggctattt acaatcgcat attacaaaat gattaaacat agtaaaaata taaaagacct
     6601 tgtatcgttt cagtcggaca ataaatattt atttatggca tataatcagg tgaaacaaaa
     6661 ggaattaggg cgtataattg caaatcaaaa aaatgaaaag attgaagtgg tatttgaaaa
     6721 ctatgagaag actttatatg aattatttat gcgtgcgccc cgttatacat cgaatgtaaa
     6781 tgtatgcgag cacatttttg gatattttaa aacaaagtta aaaaaacaag aaaaagatca
     6841 ttttatagaa ctgttacaaa agtatgcaga aaagaaaata ccacttagta gtttacttac
     6901 aattttaaaa tcatgggcta ttcgatttga tgaaaagtat ttattaagac aaacatattt
     6961 cgaaccatac cctgaagcat tagtagaaat ttctgattcc ggaaaaggta gagattatta
     7021 aacaataaat tacataattc gacacaaaac ctcctatgtt gttgtagaac aatgtaggaa
     7081 tttttttgtg cattagtaca gaatctgttt taaaattaag ttatgacaga attgtagcaa
     7141 ttgtctaact aatattcttg tctttaaagt tgttatgttt gtagtagaaa ctcgcacgct
     7201 gtcgaaactc aatattcgat aaggggtgtg tagcggaatg gaatttactc taactcgcga
     7261 aaaacaaatg attaaagaaa tggtacgtga ctttgctgaa aaggaaatcg caccgaaagc
     7321 tgtatattat gacaaaactg cagagtttcc atatgaaaca tttcaaaaaa tgggcgaact
     7381 aggattatta ggcatcccat tcccagaaga gtatggaggt tcaggtggcg atacggtatc
     7441 gtatgcgtta gcagttgaag aaattggtcg cgcttgtggt ggcaccggtt taagctatgc
     7501 tgcaacaatt tcattaggtg cttctccaat ttattatttc ggtacagaag aacaaaaaca
     7561 aaagtattta gttccaatgg cgtcaggtaa aacattaggt gccttcggat taacggagcc
     7621 gaatgctgga tcagatgcag gtggtactca aacgaaagcg gtattagatg gtgatgagta
     7681 tgtaatcagt ggtgagaagt gttggattac aaacgcagag tatgcaaata caattattgt
     7741 aaccgctgtc aacggtattg aagagaatgg tagaaaacgt atttctgcat ttatcgtgcc
     7801 tactacgagt gaaggattaa cgatttcaag tccttacgat aagatgggtg ttcgcgcttc
     7861 taatacttgt gaaatcgtac ttgatggtgt tcgtgtaccg aaagaaaata ttcttggtga
     7921 tgtaaataaa ggctttaaac aatttttata tacacttgat ggagggcgta tttcaatcgc
     7981 tgcattggca gttggtattg cgcaatcagc ctttgaacgt gcattacaat atgcgaaaga
     8041 acgtcaacaa tttggaaagt caatctctaa tttccaagcg attcaattta aattagctga
     8101 tatggcgact gaagtagagc tagcacgcaa tttagtacat aaagcagctt ggttaaaaga
     8161 taacgataaa cctttcggca aagaagcggc aatggcaaaa ctatttgcat cggaagcagc
     8221 aagccgtatt gcgaatcaag cagtacagat tcatggtgga tatggttata tgcgtgaata
     8281 tgaagttgaa cgacatattc gtgatgcgaa actattagaa attggtgaag gaacttctga
     8341 aattcaacgt ctcgtaattg ctagacattt aggatgtaga taaaagggag gaatcactat
     8401 gtttcaaaaa atattaattg cgaatcgcgg ggaaattgct gttcgtatta tgaaaacttg
     8461 tcaaaaactt ggcatacgca ctgttgctat ttattctgaa gcagatgaaa atgcccttca
     8521 tgtgaagatg gcaaatgaag cttacttagt aggtggaccg cgtgttcaag aaagttattt
     8581 aaaccttgaa aaaattattg aaatagctaa gaagacaaat gcagaagcga ttcatccggg
     8641 ttatggttta ttatcagaga atccgtcttt tccggttcgt tgcaaagaag aaggaatcgt
     8701 atttatcggt ccttcagaag aaatcattac gaagatggga agtaaaatcg aatcacgtat
     8761 cgcaatgcaa gcagcagatg tcccagtagt cccaggtatt actacaaata ttgaaactgc
     8821 tgaagaagca attgaaattg caaaacaaat tggttatccc ttaatgctta aggcatccgc
     8881 aggcggcgga ggcattggta tgcagttgat ggaaactgag caaacgctca ccaaagcgtt
     8941 tgaaagtaat aaaacaagag cgcaaaactt ctttggtaac ggagaaatgt atttagagcg
     9001 atatatagca gatgcgcatc atattgaaat tcagctttta gcagatacac atggtaacac
     9061 agtgtattta tgggagcgtg aatgttcggt acagcgccga aatcaaaaag taatcgaaga
     9121 agcaccttca ccatttttag atgaaggtac acgaaaggcg atgggagaag ttgctgtaca
     9181 agctgccaaa gcacttggct atacaaatgc aggtacagtt gagtttcttg tagatgatca
     9241 gaagaacttc tatttcttag agatgaatac gagattacaa gtagagcatc cagtgacaga
     9301 agaaattacg ggattagacc ttgtagaaca gcaactcctt atcgcaagtg gagagaaact
     9361 atcatttact caggatgatg taaaacgtag tggtcatgcc attgaagctc gtatttatgc
     9421 agaggatccg aaaacattct tcccatcacc tgggaaaatt acagatttaa cattaccgtc
     9481 aaatgtacgg attgatcact tcttagaaaa tcatgtaacg attacacctt tctatgatcc
     9541 aatgattgcg aaagtcattg cacatggcga gactcgtgaa gaagcaattt cgaaattaca
     9601 tgatgctcta gaagaattaa aagtagaagg tattaaaacg aacacgccaa tgctactgca
     9661 agttttggaa gacgaagtgt tcaaagaggg tatttataca acggggtttg taacgaaaca
     9721 actcgttaaa aaataagatt taacaatatt aagggggaaa aaaatgatga cgaaagtata
     9781 cgcatcgatg gcaggaaacg tttggaagat tgttgtagga gtaggagata cagtagagga
     9841 agagcaggat gtcgtcattt tggaatctat gaaaatggaa attccaatca tttcagaaga
     9901 agctggcaca gttatgaaaa ttaatgtgca agaaggcgat tttgtaaatg aaggagatgt
     9961 attattagaa attgaatagg gagatatagg gggaagcgaa ttgaaactac ctaattttgc
    10021 tgtcattaaa gaagtcgggc cacgtgatgg cttacaaaat gaaaaaaaga ttgttggcac
    10081 aaaagataaa gtaaaatgga ttcaactact tacagaagca ggattgtcgt atgttgaagt
    10141 ttcctcattc gttcacccaa aatgggtccc tgcattagca gatgcaaatg atgtattttc
    10201 tgagctgaaa agggatccaa atgttacata tgctgcgctt gttccgaatc aaaatggttt
    10261 ggaacgagct tttttgcaaa atgtagatga ggtgaatgtt tttttatcag caagtgaatc
    10321 tcataataaa agtaatatta ataaatcgat taaagaagcg ttagttgtaa ttgaagatat
    10381 aacaaaacag gcattattcg aagggaaaaa ggtaagaggc tatgtttcta ctgtatttgg
    10441 atgtccttat gaaggggata taagtgtcac agcagttgac gaattatgta atcaactatt
    10501 ttcatacggc atttatgaag tttctcttgg ggatacaatc ggtgtagcga atccattaca
    10561 agtagaacaa gtattagaac atctattaaa gaagtatgat gcttcgcagt ttgccatgca
    10621 ttttcataat acgtatggaa tggctctagc gaatgtagtt aaatcattag aatacggtat
    10681 taaaacgttt gatagttctt gtggtggact cgggggctgc ccttatgcac caggagcatc
    10741 aggtaatgtt gctactgatg acctagtaca tatgctccat aagttaggag tccaaacgaa
    10801 tattgatgaa gagaagttat tgagagcaag tcaatttatt caaagtaaat taaatatcca
    10861 attaccgagt catgtgtata gagcgcttca acataaaacg ataagtaggt gagaagatgc
    10921 tacaattaca aaacatttca gttgattacg taacacctca cgtagtaaag atttcgttaa
    10981 atcgtgcaag acaagtaaac tcattatctt tggcattatt agatgaatta caaactatat
    11041 taactcaaat aagtgaagat tcaaacgcac gtgtagttat tttgactggt gctggtgaaa
    11101 aagtattttg tgctggtgca gatttaaaag agcgtgccga tatgaatgaa gaacaagttc
    11161 gccatgctgt tagtatgatt cgcactacta tggagatggt tgaacaatta ccacagccag
    11221 ttattgctgc aataaatgga atcgcacttg gtggtggtac ggaattaagt ttagcttgtg
    11281 attttagaat tgctgctgaa tgtgcaagtc ttggtcttac tgaaacgaca cttgcaatta
    11341 taccaggagc aggtggtaca cagcgcttac cgagattaat tggagttggt agagcgaaag
    11401 aattaattta tacaggtaga cgtatttcag cgcaagaagc aaaagaatat ggtttagtag
    11461 aatttgttgt accagctaat ttacttgaag agaaagcgat tgaaatagca gagaaaattg
    11521 ctagtaatgg acctattgct gttcgattag caaaagaagc gatttcaaac ggtattcaag
    11581 ttgatttaca taccggatta caaatggaaa aacaagcgta tgaaggtgta atccatacga
    11641 aagatagatt agaaggatta caagcattca aggaaaaacg cacaccaacg tataaggggg
    11701 agtaaatatg ttagatcaaa aacaacaatc gaatacattt gaagaacgag ttgaaacgat
    11761 taaacaaggc ggcgcaccaa aatatcatga acaaaataga gcaaaaggaa aattatttgt
    11821 tcgagatcgt ttagcgcttc tatttgataa tggcgaatat gtagaagatg cattatttgc
    11881 taactgtgaa caaacaggct tacctgcgga cggcgttgta acggcaacgg gtaaaataca
    11941 tggtcgtact gcgtgtgtaa tggccaatga ttctactgta aaagctggat cgtggggatc
    12001 acgcacagtt gaaaagattt tacgtattca agaaacagct gaaaaactac gtgttccgtt
    12061 attttattta gtcgactctg ctggagcacg tattacagat caagtagaaa tgttcccagg
    12121 gcgccgtggt gcagggagaa tcttctataa tcaagtgaaa ttatcaggta aagttcctca
    12181 agtatgctta ttatttggac cttctgcagc tggtggtgcc tatattccag ccttttgcga
    12241 cgttgtaatg atggtagaag gaaatgcatc tatgtattta ggatctcctc gtatggctga
    12301 gatggttatc ggtgagaagg taactttaga agagatgggc ggagctcgta tgcattgctc
    12361 tgtatcagga tgcggagatg ttttatgtaa gacagaagaa gatgcgatta cacaagcaag
    12421 acaatacatt tcatattttc caaataacta cttagaaaag actccattgg ttacacctca
    12481 agaaccgaaa caattcgata aaacgttaga acaaatcatt ccagaaaatc aaaatgctcc
    12541 tttcaatatg aaagatctca ttaatagagt tattgatgaa ggttcattct atgaagtaaa
    12601 aaaattattt gctcaagagc taattacagg cttagcacgt attgatggta agccagttgg
    12661 tattattgca aatcagccgc gtatgaaggg cggcgtatta ttccatgatt cagctgataa
    12721 agctgctaag tttattaatt tatgcgacgc atatcatatt ccattattat tccttgcgga
    12781 tgtaccagga tttatgattg gcacaaaagt agagcgtgct ggtattattc gccacggtgc
    12841 aaaaatgatt tctgcaatga gtgaagcaac tgtaccgaag atttctatcg ttgttcgtaa
    12901 agcatatggt gctggtttat atgcgatggc aggtccagca tttgaaccag attgctgcct
    12961 ggcattaccg acagcctcta ttgcggtaat gggtccagaa gctgcggtta atgctgtata
    13021 tgcaaataaa attgcagctt taccagaaga agagcgtgct agcttcattg ctgaaaaacg
    13081 tgaagagtat aagaaagata ttgatattta tcatttagca tcagagatgg tgattgatgg
    13141 tattgttcat ccaaacaatt tacgtgaaga gttaaaagga cgtttcgaaa tgtatatgag
    13201 taaatatcaa gtattcacgg atcgtaaaca tcctgtatat ccagtttaaa agccctattt
    13261 agggctttct tgctcaaaaa gttaaggagg ggaaaacatt gaaacaagca gtttggtttc
    13321 caacagaaga gtacaaggaa aaaacacgtt tatatggttg gatgaaatca ttgggatatg
    13381 aagattatga aactttttat aataaatcta ttgaggaaac agcttggttt tggggagagg
    13441 cagaaaaagc agttggctat caatggatga aaccttatac agaagtatta gatttagaaa
    13501 atggtacacc gtttgcacag tggtataatg gcggaacatg taacgttgta gaatcagctt
    13561 tatcccgctg gcttgcggat gaagagacga gaatacagcc agcacttcag tacgaagggg
    13621 aaaatggaac ttcaaaatca tttacatatg aagagcttga caactgggta agccgtgttg
    13681 caaatggttt gaaacacgcg ggtattgaga aaggtgaccg tgtaacaatt tatatgccga
    13741 tgattccaga aacagttgtt gcgatgctag ctgtaatgaa aatcggagca attatttcac
    13801 caatattctc aggctttgcg tctgatgcag ttatgacacg tgtgcaagcg gcaggttcaa
    13861 aaatgattat taccgcagat ggattttcac gccgcggtaa aattgtttct ttaaaagatg
    13921 aagtagataa agcttgtgaa cattgcccaa ctgttgaaaa agttgttatc gttcgtcatg
    13981 caggaaatga ttttacacca cataactatg acttttcgtg gagtacgcta gaaaaagaaa
    14041 aaccattcat acatgccgag aaaatgcaaa gtgatgatcc attaatgctc atttatacat
    14101 caggaacgac tggtaagccg aaaggaacag tacacacgca tgcaggattt cctttgaaag
    14161 cagcttttga tgcaggattt ggaatgaata ttaaacaagg tgatcgtgta ttatgggtaa
    14221 ctgatatggg ctggatgatg gggccgtttc tattattcgg ttcactcatt aatggagcaa
    14281 cgatggttat gtacgaaggt gttccagact tcccagaagc agaccggtta tgggagacag
    14341 ttgataaata tgaaattact catctaggta tttcgccaac gttaatccga gcattaatgg
    14401 caaaaggtga tgagtatgtc aataaacatt ctttaaagag tttggaagta ttcgcatcaa
    14461 caggagaacc ttggaatcct gatccatgga tgtggctgtt tgaaacagtt ggaaaaggaa
    14521 atgttccaat ctgtaactac tcaggtggaa ctgaaatctc tggtgggatt ttcggtaatg
    14581 ttcttattaa gccaatcgca ccgattagtt ttaacgcatc tttaccagga atggcagctg
    14641 tcgtgctgga tgatcaaggt aaaccaattc aagatgaagt cggagaatta tgcttagaga
    14701 aaccttgggt aggtatgacg aaaagcttct gggaagatga tgaacgttac gtgaacacat
    14761 attggtcgcg ttttgaaaat aaatgggtcc acggtgactg ggtcatttac gatggtgaac
    14821 aatatatcat cacagggcgt tcagacgata cgttaaatat tgcaggtaaa cgtattggac
    14881 ctgctgaata tgaatctatt cttgtgaaac ataatgatgt aatcgaagct gctgcaattg
    14941 gtgtacctga cgaagtaaaa ggtgaagttt gtcattgttt tgtagtgtta agagatcatg
    15001 taacattcac aggagaatta aagaaagaat taatgagttt agtaaactct catattggaa
    15061 aagcgttgtg tcctaaagac atccacgttg tagaagattt accgaaaaca cgtaattcta
    15121 aagtaatgcg ccgtgttatt aaagcagctt atttaggaaa agaattaggt gatttgtcgt
    15181 cacttgtaaa tcctgaagta gtaccgttta ttcaagggtt acagtctagt aaattataaa
    15241 attagaaagg agctctatat aaacagagct ccttttttat gtttataaaa agagaagaag
    15301 tgaagttgat gaagaagaaa aattctacta ttggtgttaa gtatgttttt tagttttaat
    15361 caaaatacga tattatggaa tgtctattca atggagaaat actaatttac aacaacaagg
    15421 tgatgacaaa gcgcgactgc ttatatgccg gtttaaacct ttacgtattc attgataaaa
    15481 agctgactat actaagtcag ctttttatat attacatcct agtatttatc tcgctatttg
    15541 ccgagcagta atgcccccac ctaaaaattc agcgaaagca aggaagtagg tgagggatca
    15601 actttccgga aaagcccgat tgattccaaa agacatattt tttcctttac gttgacatta
    15661 aaaatattac caattttttc ttttacaatg gcaacaaata aagaaacatt tacaacgaca
    15721 cttatttcgt ttaaaactcc aatcatcatc acgatgacac ttttctttag atttccacca
    15781 atcatcatta caatgttttt cctgagaact ccaatcgtca tcacaatgac acttttcttc
    15841 agatttccac caatcatcat tacaatgctt tttctgagaa ctccaatcat catcacaatg
    15901 atgcttttct ttagatttcc accaatcatc acaacaatgc tttttctgag aactccagca
    15961 atcatttttc caagacattc atttctacct cctttcaata gtgttcatat tattctatgt
    16021 tttaataaaa aaatggcttg tttattaacc tactatttta tctttatatg atagagtgtt
    16081 ttctactcga tatagagttc atacaaacta tgctaatttt taagagatag tggagagaac
    16141 tactactagt tatggtgttt tccaataaac atttgttgaa gaaagcgttc tgattacata
    16201 taatatctta ttttcgagta cgctttttta aatgtatatt tcacaatgaa aaatgggaaa
    16261 tccacaaata aagtctatgt atatgtgagt taatgggaaa atctagtgtg tttttaaggg
    16321 gcatcttatt aaaagaaaaa gatttgtttt agaaagtggt gtctaaacat taaatggagt
    16381 aggactaaat tcacggccgc tcattaaaca agattttaat taggagaagt ctgtttttat
    16441 aatgaataat gaaaagaagg tttggtacaa ttgtttgttt ttttcttttt atgtgtttgc
    16501 ctcgtaccct tttaagctag tggacatact ttactaatag aaaggattag ggggtgaggt
    16561 attgggttct cgatttaata attgtaaaaa gaagtgtaca tgtaaacaag atgattgttg
    16621 ggaagtattc gaagagtgta aaaaagaaca gcatgagaaa tgtgataatt cttgtgtaca
    16681 aggaattaga gatgaactta agaaattaat taatcgaaca gttcaaatta atacagaggg
    16741 acgtacttat gtaggtactg tttcgtctgt aagttgtgat gtagttaggc ttgcggctat
    16801 tcctggatcg gttggagtaa ttatttccat ttgtaaaatt gaagcaattt tcccacctgt
    16861 tacaacggtt actgctgact ttgattttaa tggtattgat gtagcaaaca aagcataatt
    16921 atgctgcttt tttgtaaagc cattcacatg aatggcttta ttttaatttc atataaaagg
    16981 agaatatatt ctttatatag aaataagttt gaggttataa agtatgatgt acgaaaggag
    17041 catggaagtg attaaactaa aaacctttaa aaaatctgat tttaaacaat taataaattg
    17101 gattaattct gaagaatttc taatacaatg gtcaggaaat gcattcacat tccctttaga
    17161 cgaacagcaa ttagagaagt atatagaaag tgcaaataca ctcgctttca aagtggtaga
    17221 tgaagagact tcagacgtta ttggtcatat ttcgcttggg caaatagata atattaataa
    17281 gtccgctaga attggaaaag tattagttgg taatacgaag atgagaggac gttctatagg
    17341 aaaacatatg atgaaagcag tacttcatat tgcttttgac gaattaaaac tacatagagt
    17401 aactcttggt gtgtatgatt ttaatatatc ggccatttca tgttacgaaa aaatagggtt
    17461 tgtaaaagaa ggcttattaa gagagtcaaa aagagtagga gaaacgtatt ggaatttatg
    17521 ggaaatgagt atgttagaat atgaatggaa gaagtagcaa caatagtaat ttataattat
    17581 attatgttaa caaaaggggc ttggtgggta tagtggataa taaaacaaaa ataatctcaa
    17641 ttgcagctgt ttcgggggag agctagtatg ttaaaactga caaagaaacc atttttgaaa
    17701 aaggcccacc tgcattgttt ctgaggaata agagggtgag ccctaattaa acgaaactga
    17761 atgaatctgt aaaaattgta actaaagtat gcatcaacaa ggtattaaaa gggatgaata
    17821 gtaaccttta tagattattc catatatagc aaaactggtt agcttctgat ttaagcgcta
    17881 ctaaatgatt attattaata gagttattcg tatacattct gttcttttgg atgttaagta
    17941 ccgtataatt cacatcgttt cgttcatttg aaaatgttga ttcatttaat agtgtaagtg
    18001 tcgagttaat gttgtactta tcaattcgct ctttttttcc tttgaaaaac agtttgataa
    18061 gatgtggctc attattaatg aataagccaa gttcaggtga tgaacggacg attaaatcat
    18121 ctgatttcca atgtgattta cctggatcaa accaagagat gtctttattt ttaatgaatt
    18181 ttttgtattg ctttatgaca tcaatgtagt tttgtttttt tttctgatca accgtttgta
    18241 ctaatgtttc gaaatattca aaaggtagtt tgttttgatg aaatttaata acagtttctc
    18301 gtaattgttt ccagtaatca aaagctggtt gatattcagg ttgggatttt agatttttta
    18361 taaaggttgt tttagctgta ctacctttca gtgtgaagtc taaaaattgt gtaagcccta
    18421 ctttaatttc tgccatatta tatccccttc caaacattat tcatttaata atagacgaaa
    18481 aatccgacat ttttaaagaa atgagctaga tgctagaaaa tccaatatcc atgcacaata
    18541 gatacgggaa agccaatccg taagtataaa tgatggacca ttcaattgaa gataaattag
    18601 gtaataggat tttatcaggt gataggttat taatataatc agatagtgag ctgattttaa
    18661 aagataacaa tatagattat ttagcttgga tttgagaaaa aaagtacatg ggaataaaga
    18721 gggatatagg gaaatgggcc ctcatcaaaa aatataagtt ggtatcagta taccgtagag
    18781 aatgagtgta tagaacatac aagtaaaagt attggcaagc atacttaaaa taagccgtat
    18841 aaaaagttaa tcattgtgtg ctttgataat atagcgtcag cgaaataaat agtgtgaagg
    18901 agagctatct taacaagtgt ttcatgtaac gttcatatac tttaatttta ttattaatca
    18961 aacttgaata ttatagaaac ggataatgag gtatgggtgg tgctcttttt tattgaataa
    19021 aatgggttga tttttcggat tttcattaca atataacaaa taaaatttaa attttatttg
    19081 ttgttaagaa aaggtgagaa gaaaataaaa aaagagggct aatgccctct tttcttatta
    19141 atttggtaat taatcacaga ttggtatccc aagcactctt agagctaatg ctacttgaag
    19201 ggaaatctct aatctagcaa tttcaatacc agctactgaa agaactaaaa aaggttgtcc
    19261 gtttacaaat acaacgcaac tatccatagt taaacctcct ttctagtaat ctactatagt
    19321 atatgaatag aactttaaag tgtaatagtt aaattgttgg atttaataga attaatagat
    19381 taacccattt aaactaaaca aacgaataca acgaaaggaa acagagatgg atgtatgcct
    19441 caaaaaacat aggttttaag acatgtaatc gtacatgaaa tccatcatat tggtcagcta
    19501 tctatatggg cgagggagtt aaacttgcaa ccagtttcag caaatttgat tggacgagga
    19561 tgatagaatt aaaaaccgac ttgcatctca agcgcaagtc ggtttttata tataagaaga
    19621 tttcttaatt gaaatcttcg gattttttct gacgtatatg taaaaacatt aaggtggtaa
    19681 tgattaagaa aatcattata gtttgtataa ttaagttttt aaactgaagc aatattgtcc
    19741 aagatgtaag ggtgtcttta aaagcttgga gtgcagagta cgaggaagga tcaaaaccat
    19801 actgtagcaa cttttttgtt tcaataaatg aaatgttttc ttcatctgca tctaatatta
    19861 ctgaaattag tctagtatct cctagttttg ctgtactgac aaaactataa ttaccgttag
    19921 ttgaaaaact agtttgtaag ccatcaacac cttgaagttt aatgttttca ttaagggaat
    19981 atatcatttt attcgtattg aaaacctggg aatctttgaa ggtaaattgg taagaggtta
    20041 gtttcgtaat attcaataca tctggaaaat cttttactaa ttgtgcagct agtttagctg
    20101 cgtctattgc tgttgtagtt gattgtttat ttgtatcatg attaattcca gtagagttta
    20161 gaaatggaga tggttgtaat aactgtagtt cttttgcttt tttattcatt aatattgtaa
    20221 agttatcttc agttccagca atgtgttctg ctagagcgag tgcagaacga ttattccctg
    20281 ccagtagcaa tgcatgaagt aaatcacgaa ccgttgtttt atcattcgat gttacttgta
    20341 tagggcttgt ttctactcgg aaaacttcgt tacttatttg tacgaagtca tctaactgta
    20401 tttttctatc atttagttgt tccaatacga tatattccgt cattaattta gataaagtag
    20461 ctgattgtac tggggtttct tcattttttt tataaacaat ttcacctgaa ttagcattta
    20521 ttaaaatagc tgatttagct tgaataatcg gaccatttac ataaagataa aaatataaaa
    20581 cgataagtgc agtaatgaaa aaagataata ataaaatagc gaattttttt aagaattgca
    20641 taagtgatcc tcctattatg acatcaataa tagtattgta aaaaggaatg cttaattagg
    20701 aagaaagaaa aggtaaagaa tttctaaaga attataaagg attattaaat ttagggaaat
    20761 aatagaaaaa gttcaatttc ttatatgata agaaattgaa ctttttattt gtaatattaa
    20821 catttgtatg gaagtagttt tacagtgaat gttgtttttt cgtcatcact atatacttca
    20881 attgttcctt tatgcaactc gactatactt tttgcaattg ctaatccaag tccagatcca
    20941 ccagtgtttg tagagcgaga tttctcaacg cggtaaaaac gttcaaaaat atgaggtaaa
    21001 tccgtactag gaataggttg tccgtaattt gttatatcaa ttgtaatcat attattgctt
    21061 tcataagcag taaggtcaat atagcgacct tcgcttccat aagcgatagc gtttataata
    21121 agattttcaa acacacgcac taatttgtca ccatcagcta ataccataag cttttgagac
    21181 gggaaagaag gccgacattc tatattagct tcttgaacct gtatgcggaa ttgaacagtt
    21241 aattgtccaa gtaactctac aatatcaata ggaacagaat acaagcttaa ttctttattt
    21301 tgaacacgtg tatattcgaa caagtcattc attaatgcat taagacgagt tactttatcg
    21361 taaatgactt gaatatagta tcgcaattcc acttcatctc tataattatc atgatggatt
    21421 aaatttacgt atccaactat agaagtaagg ggggtgcgta agtcatgtga tacatttgta
    21481 ataagttcac tttttgcttg ttccgcttgt ctttcttcat caatggagac ttttaattgt
    21541 tcaacaattt cattgacccc gattgctaat tcttctagat aattatgatt tacaatagaa
    21601 actttatgat tgaagtttcc atttgcaata taacgaattt cttctatcat tttttttata
    21661 caagtttcat aataaagttt tttctcgtga cgataaaaaa tgtaaagata ggatgaaaaa
    21721 atagaaaata aaaacaaata agatacaatc atcatccata aagactcttt aatcccttta
    21781 tacttttcat aaccaaaaat tcgaatgaat tctttaccga gttcagttag agtaagtgaa
    21841 ctctcaatta cactcgtaac gaggcgataa ataattagtt cagtaatagg agtgagtgtg
    21901 atagctaata aaagccaaaa aataagtttc catttaggaa tatcttttaa tatatcaaat
    21961 gcttcatttc tcaattttat agccaactcc ccaaacagta tgaatcaatt tttctccatt
    22021 cattactgtt tcaagtttat ctcgtaagtt gctaatatgg accattaccg tcttatttga
    22081 accataacca tcttcattcc aaacgcgttc gaaaatttct tctgaactaa atactcttcc
    22141 tgtattactc gcaagtaaat ataaaatatc gaattcaata gaggttagtt taatatactc
    22201 tccatttact ttaactgtat gattatgttt gtgtatttca acagagcgaa tacgaataat
    22261 accatcttca ttcttttgcg aagtagcatt ttggaaagag gatcttcgta ataaagcttt
    22321 cactctagct actaattcta atggattgaa tggtttgatc atataatcat cggcacctgt
    22381 cataaggcct aatattttat ccatatcttc tgcttttgca ctaagcatta gaattggtac
    22441 agtattattt tcacgtactt cctgacaaac ttctaatccg tttcgttttg gcatcataat
    22501 atccaaaatc ataaggtcaa cttcatatgt agaaaccttt tgcaatgctt catcgccatc
    22561 ataagcttta taaatgttat agccttcatt tcgcaaataa acagcaagta attcaacaat
    22621 ttctttatca tcatcaataa ttaatatatt tttattcatt gtgtagttcc tttccttaca
    22681 aatcatcaac attactataa tatcaaacat ttatgtactt gtagcgatga ttctgtataa
    22741 aatttcatgt aacgtattaa aaaggagtaa aaagattaat aacgaatata aaataacaag
    22801 gatatttaga ttctacatta taatggaagt tagttataag ggggattttc tatgttatgt
    22861 aatgatatat atttatttac tccaactgga aaaatagaca atgatattaa agtttttcta
    22921 ctaaaatata ataaagagtt tacatataaa cattcaattc gtgtggcaaa tgaggcaaaa
    22981 aagattgcag aaaagtttca cgtagataaa gaaaaagcag caattgcagg atatttacat
    23041 gatattagtg ggatttttcc gaacgaggag cggattgcag ttgctgaaga atttggggta
    23101 gaaatagtgg aaacagaaag aaaaattcct atgattattc atcaaaaatt atcgagagta
    23161 atcgcaaaag aaatatttaa agtagaagat gaagaaattt taaatgcaat ttgttgccat
    23221 acaacgttgc gtaaacatgc aacgaagatg gatttagtat tatttgttgc agataaaata
    23281 gaatgggatc aaaacgggac accaccatat ttaatagaaa taaaaaaagg attggaaaaa
    23341 tctttggaaa aagcagcttt tgtatatatt tcatatttgt gggaaaggaa agatacattg
    23401 aaagttatac atccgtggct agaagaagca tactgggatt taaaaggaat tttacagtag
    23461 aaaggacaag gaaatgcaat taaaagaata tatgaatcaa acatttccag gagttacatt
    23521 aggaccctac ttatattctc agtggggaaa tcatttacat tttgatttcg gaaaagataa
    23581 atatcaaatt gtagaaggaa ccaacgattt aaatatggaa tacttttctc aactatatac
    23641 atataataaa ttcttatttg aagatatatt ttcaaaagaa gatgtagtgt ttgtagtgac
    23701 aaatgtttat agatttaaaa aggaaaacat aaaaactcca cagaaaataa atgtatacaa
    23761 taaatatatt aagaaaagag atttaagatt tcatataaga caagaaacgt taccgtttct
    23821 atttgaagat gaagaagcag atttatattg tacatatcat ttttctttaa aatgtcttgc
    23881 ggaagatatt aagtatgaat tgcttataca agctgctaat cacgaggatt tctctgctct
    23941 gtatcctcga tttggacgaa aaaaagaaat ttcttatcca gatgtatttc tcataaatgc
    24001 aacgaaagat attgtcatgt ttatgtgtga tgatagagga tgtgaagtaa ttgcgaagaa
    24061 taaagaaata atacgagatt tatataagaa atacaaagaa tggattccag attatgaacg
    24121 agaaagtata gataacttat ttaaatgaca ataggggaag tgaagcgtgt aatgaaacgt
    24181 attgcaatag tatctgcatg ggaaccagaa ctgacgtatt tgcatcaaca ttatccgagt
    24241 gaacgtgttg aaaaaagagc agcttgggaa tttcattttc atactattta tgagctggaa
    24301 attatatcag ttgttactgg tgttggtaaa gtaagctgcg ctagttgtgt acaattgtta
    24361 attagtgagt ttcagccaga tgagttgttt atgacaggaa tatgcggaag tttatcaaac
    24421 aaggtgaaaa acggtcatat tgtagtggca ctaaacgcaa tacaacacga tgttactgca
    24481 gctggctcag gggaagatgt ttttaattta tataacggta gaacagcacc tattgaaaca
    24541 acaaaatcac ttgtaagaag aataaaaaaa atacgatcat atgatccaat acatttcggt
    24601 acatttttat ccggagatca acgtattcgt agttcagaaa tgagatattt actccatacc
    24661 gtatatggag cattggcagt tgatcaagaa gtagcagctt tcgcctatgt atgccaaata
    24721 aataaaaaac catttctatg tttaaaagct gcttcagatc aagcaaatga taaaacgaaa
    24781 gaagaacaaa aaatctttaa aatgctagca tgcgaaagag catgtgagca tttaattgct
    24841 tttttgcgtg tttatgagat taatgtagta aataatagat agtttgttat aaaacaaatt
    24901 aatagtgggt tatatgtagg gaaatgtccg ttcatttcaa attaagagct gaaatttata
    24961 atagatggaa tatattatat gggtacatgt tgcggttaat acaagcaatt ggagggcaat
    25021 tttatatgat tcaatataaa agatgtagtg aagtaaatat tgatttagta tatgaagctt
    25081 ttaaagatgg attttccgat tatattatta agatggaagt ttcaaaaggt gattttatac
    25141 accgtttttt gggaccagaa ggtaatttgc tagaacattc ttttcttgct ttagacggtg
    25201 acaaatcagt tggcgtaata ttaggtggta taaaggatt
//
