LOCUS       NZ_CP045480            25170 bp    DNA     circular CON 15-AUG-2024
DEFINITION  Amycolatopsis sp. YIM 10 chromosome, complete genome.
ACCESSION   NZ_CP045480
VERSION     NZ_CP045480.1
KEYWORDS    RefSeq.
SOURCE      Amycolatopsis sp. YIM 10
  ORGANISM  Amycolatopsis sp. YIM 10
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1  (bases 1 to 10312959)
  AUTHORS   Ruckert,C., Guerrero-Garzon,J.F., Zehl,M., Rezaei,S., Selivanova,G.,
            Urban,E., Busche,T., Kalinowski,J., Cao,Y.-R., Jiang,Y., Jiang,C.-L.
            and Zotchev,S.B.
  TITLE     Complete genome sequence of Amycolatopsis sp. YIM 10, isolated from
            a rare earth mine
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 10312959)
  AUTHORS   Ruckert,C., Guerrero-Garzon,J.F., Zehl,M., Rezaei,S., Selivanova,G.,
            Urban,E., Busche,T., Kalinowski,J., Cao,Y.-R., Jiang,Y., Jiang,C.-L.
            and Zotchev,S.B.
  TITLE     Direct Submission
  JOURNAL   Submitted (11-OCT-2019) CeBiTec, Uni Bielefeld, Sequenz 1, Bielefeld
            33615, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2.8
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 80.5x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_009429145.1-RS_2024_08_15
            Annotation Date                   :: 08/15/2024 04:03:36
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,775
            CDSs (total)                      :: 9,711
            Genes (coding)                    :: 9,634
            CDSs (with protein)               :: 9,634
            Genes (RNA)                       :: 64
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 49
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 77
            CDSs (without protein)            :: 77
            Pseudo Genes (ambiguous residues) :: 0 of 77
            Pseudo Genes (frameshifted)       :: 22 of 77
            Pseudo Genes (incomplete)         :: 65 of 77
            Pseudo Genes (internal stop)      :: 1 of 77
            Pseudo Genes (multiple problems)  :: 11 of 77
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 18:01:44
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7348590
            Orig. end                         :: 7373760
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP045480.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Annotated using prokka v1.11 from http://www.vicbioinformatics.com.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..25170
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="betalactone"
                     /region_number="30"
                     /rules="(HMGL-like and AMP-binding)"
                     /tool="antismash"
     cand_cluster    1..25170
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(HMGL-like and AMP-binding)"
                     /kind="single"
                     /product="betalactone"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25170
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:15170](+)"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..15170
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
     misc_feature    complement(187..205)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 17.5"
                     /tool="antismash"
     misc_feature    complement(304..324)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 20.62"
                     /tool="antismash"
     gene            307..3171
                     /locus_tag="YIM_RS34605"
                     /old_locus_tag="YIM_34790"
     CDS             307..3171
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040127.3"
                     /locus_tag="YIM_RS34605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YIM_34790"
                     /product="DUF6531 domain-containing protein"
                     /protein_id="WP_153034311.1"
                     /transl_table=11
                     /translation="MADPLFAEKRGPVDVATGEVVLAQADLTLTGRPDLVLRRTHLSSY
                     RAGRWFGASWASTLDQQLLADELHLRLFTADGRVRCYPHPTGADAVFPLTGHGHPLRRH
                     ADGDRVETPDGVLLFEPGHGPGGRRLLAIEHPGTPPATIEYTDGGAPAVLRGAAGQEVR
                     FTTADGRITGIDVVGDGITTAVVRFGYNKLGQLVQVANAGGPPMLLDYDLSDRLIGWQD
                     RVGTWYRYAYDAGGRCVRTIGADGFFSGAFAYDDARRATLHTDALGHTTEFRFDEAGRL
                     TEEVDPLGGRHGYSWDQRGRLFSRTDPLGRTTLFTYDEALTGLIRPDGSVVSYSPDTLE
                     VSTEDVRRSYASVPDPPAEPVGVAVPWRATGPDGPFADEPPDDDPSAERDAFGRPRTAR
                     TASGATVGLGWTVAGHRAVRQGPLGRRDVWRFDAEGNAVEHRDAAGQVSRRRYGRFGLL
                     IAEIDADGGRTTYTYDGRARLTSVTNPVGLTWRYAYDPAGRLIEEEDFDGRLISFDYDV
                     AGQLTRLTNGLGEVTEFRYDRLGNLVEQRTAEDVTTYAYDPLGRLVHAANRDSVLEISR
                     DALGRVLIESVNGHEVRWRYDDEGTHRRTPSGVDSSWRPDSLALAGHEIRIERDAAGRE
                     RTRFVDGLRVLAQRFDAEDQLVEQVLAHGEQVLKKREFTYRIDGRLIAVDDSVGGPTRL
                     RLDALGRVTESTGPRGTRRYRYDAAGNITKAGAETRTYHRNQLLEAGRTRYTADRQGRV
                     TERWSADGAWTFTWDRLDRLTELTTPDGARWTYSYDALGRRFAKQRWVSGAVVEETRYA
                     WSGTEIVERDGTDSVVTWAHDRDGRLVAQSSPGTFSSIVTDADGSPTELLDGDGTLRWQ
                     SCAWDAPCWDADAESGLHHHFDRYFDPGIARYLSQDPLGLRPGPNPVARHPAQARGSAS
                     AVPHRPGSGYHRGVAVHPRTGGGG"
     gene            3182..3805
                     /locus_tag="YIM_RS34610"
                     /old_locus_tag="YIM_34795"
     CDS             3182..3805
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020642068.1"
                     /locus_tag="YIM_RS34610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YIM_34795"
                     /product="TIGR03085 family metal-binding protein"
                     /protein_id="WP_153034312.1"
                     /transl_table=11
                     /translation="MGVATDERQALCGLFEELGPDAPTLCEGWRTRDLAAHLVVREHRL
                     DAAAGILVPFLASHTESVQRRYATEPWEKLVDRVRSGPALLWPTRLPPLNELVNSAEFL
                     VHHEDVRRGQEGWEPRPAEAARDAAAWRSVRAIAKLTLRNSPVGVLLRAPGHGEVVLKG
                     PDPVTLTGGPLEILLFAFGRDAVRLEFDGELTAIARLKSLSRGL"
     gene            complement(3802..4221)
                     /locus_tag="YIM_RS34615"
                     /old_locus_tag="YIM_34800"
     CDS             complement(3802..4221)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1284:
                     transcriptional regulator, MarR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007029224.1"
                     /locus_tag="YIM_RS34615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YIM_34800"
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
                     /protein_id="WP_153034313.1"
                     /transl_table=11
                     /translation="MAERTRPDLAAMLGGLMRRLMAAEAPVLAEHGLSMWGYVVLSALD
                     DGPVRTQAALARAIGADKTRIIGTLDELQEAGLISRDPDPADRRVRVLAITDEGRARRR
                     GAQKQIQAHEDELLAGLPATDRAAFLRAAQALAES"
     misc_feature    complement(4250..4265)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 18.27"
                     /tool="antismash"
     misc_feature    complement(4259..4273)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.18"
                     /tool="antismash"
     misc_feature    complement(4270..4284)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.62"
                     /tool="antismash"
     gene            4275..4880
                     /locus_tag="YIM_RS34620"
                     /old_locus_tag="YIM_34805"
     CDS             4275..4880
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007029225.1"
                     /locus_tag="YIM_RS34620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YIM_34805"
                     /product="TIGR03086 family metal-binding protein"
                     /protein_id="WP_153034314.1"
                     /transl_table=11
                     /translation="MPINELRILDALATSASLDLVDRVEPADLAKPTPCEAWTLHGLLA
                     HMTTQHLGFAAAAGGDGDPENWKLVPLGDDPAATYRDSVNKVLNAFAADDIADRKFPLP
                     EFTTEFTFTAEQAISFHFVDYVVHSWDVARTLGLPLTFQREVLDAAARIAEIVPDGQSR
                     LAPGAAFGPAVAADGLSGLDRIVALLGRSPSWAPNGSR"
     gene            6334..7362
                     /locus_tag="YIM_RS34625"
                     /old_locus_tag="YIM_34815"
     CDS             6334..7362
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020662406.1"
                     /locus_tag="YIM_RS34625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YIM_34815"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_153034315.1"
                     /transl_table=11
                     /translation="MGKPQRTVRLRFTVLYASLFLVSGIGLLVLTNLFTVTAPADFPEQ
                     LEVVRARQLLAGSLIALGVMLVVSVLLGRFVAGRVLRPLRTITAATRRITAENLHERLA
                     VPGPADEVKHLADTIDDLLERLEASFAAQRRFVANASHELRTPLATMRASLDVAEAKPE
                     PRLDHQLAERFRTELDRVDQLLEGLLALARVQHGAFADQGEVSLRDLVTEALRARETDI
                     AAKDLKVERELGESRVHGSPALLSRLVANVLDNAIVHNERGGWIRVTTGDNGFEVETGG
                     AVLDQADVDRLADPFRRLAADRTTSDGGSGLGLSIVAAIAEAHGRRLRLKARSDGGLRV
                     TV"
     gene            7359..8033
                     /locus_tag="YIM_RS34630"
                     /old_locus_tag="YIM_34820"
     CDS             7359..8033
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015800367.1"
                     /locus_tag="YIM_RS34630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YIM_34820"
                     /product="response regulator transcription factor"
                     /protein_id="WP_194239851.1"
                     /transl_table=11
                     /translation="MRVLVVEDARALADVIAEGLRDQGMAVDLAYDGHTAAAKLDLHPY
                     EVVVLDRDLPGIHGDVLCGLITEREDRAMVLMLTAAGSPVERVSGLTLGADDYLAKPFH
                     FPELVLRIRALARRRPSARARILRAAGIELDPIRRTATRDGRPLDLSVKEFNLLTALLQ
                     AGPAWSSTEELLDRVWDEHTNPFTNTVTVTIGRLRRKLGDPPVITTLPGAGYRLTDPGG
                     SP"
     gene            complement(8008..9357)
                     /locus_tag="YIM_RS34635"
                     /old_locus_tag="YIM_34825"
     CDS             complement(8008..9357)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1106: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005157516.1"
                     /locus_tag="YIM_RS34635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YIM_34825"
                     /product="MFS transporter"
                     /protein_id="WP_228004203.1"
                     /transl_table=11
                     /translation="MAEPPSATERPDAAVDRPATYRTIALRVMPLLVICYVVSFIDRTN
                     IGIAQQGLKRDLGFGPAVYGLGVTLFFVGFILFEVPSNALLARIGARKTLVRIMASWGV
                     VTVATMFVQDELTFYLARFLLGVTEAGFFPGALYLLSRWFPSARRTRMTAVFFIGVPVS
                     GVLGSLVSGWIMHTFGGVGGLADWQWLFLLEGVPPILLAVLVLFFLADEPEQAKWLTPA
                     QKAAVRADLEADRRRKGDVADHAEAHGGLLVALRDTKVWILGLCACGAYTLANAVSYWT
                     PRIIADAGVGDVLNLGLFSAIPPLLGIVVMLVVGRHSDRTLERRWHAATSWIVAAFAML
                     ALSVSGGNVVVVILLLAIMAAAHYSGLTVFYSIPSIYLTDRAAATGIAVVTSMGSFAAA
                     ASPSLLGFIQSATGSLSLGLQISAGIVLLAVVLLLTGVKAGDLKETRPDR"
     gene            9456..9941
                     /locus_tag="YIM_RS34640"
                     /old_locus_tag="YIM_34830"
     CDS             9456..9941
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1284:
                     transcriptional regulator, MarR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020636754.1"
                     /locus_tag="YIM_RS34640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YIM_34830"
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
                     /protein_id="WP_153034316.1"
                     /transl_table=11
                     /translation="MSERADGRDLVPISALLSYRLSRTSSAMSRSAALRYKREFDVSLG
                     EWRAIALIAADPTLTLNRLARRAGLDKAQMSRVVSRLTERGLVNRTAGSGRTSQLALTE
                     EGTRVYRGLITAANERDAAFLAILSDEEATVLQSALDKLAELALTVEQRERAHADQP"
     gene            10001..10942
                     /locus_tag="YIM_RS34645"
                     /old_locus_tag="YIM_34835"
     CDS             10001..10942
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: HMGL-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1271: 2-isopropylmalate synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020667400.1"
                     /locus_tag="YIM_RS34645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YIM_34835"
                     /product="hydroxymethylglutaryl-CoA lyase"
                     /protein_id="WP_153034317.1"
                     /sec_met_domain="HMGL-like (E-value: 2.3e-38, bitscore:
                     131.4, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPGSTTDAVTICECFARDGLQHEPVPLPTATKIALLNSFVDTGFR
                     RIEATSYSHPARVPGFSDASEVLAGVDRREGVAFKATCPNPRAVSRALADLDAGHGAEE
                     LSLLVSATESHTERNLRTDRDGQWARVTEMVRLAGGRFRLVGVVSVAFGCPFEGAVDPG
                     RVAEDVARFAELGASMVTLGDTTGVATPGAVRAMFTRLGRAHPGLPVIAHFHNTRGTGI
                     ANAVAALEAGCRHFDTAFGGVGGHPSTISYGAGLTGNACTEDLVSLFDAMGVETGLDLD
                     RLAAASAACERALGRPLHSMVARAGFNPQETP"
     gene            10939..11655
                     /locus_tag="YIM_RS34650"
                     /old_locus_tag="YIM_34840"
     CDS             10939..11655
                     /NRPS_PKS="Domain: ECH (6-214). E-value: 6.6e-53. Score:
                     171.5. Matches aSDomain: nrpspksdomains_YIM_RS34650_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020667401.1"
                     /locus_tag="YIM_RS34650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YIM_34840"
                     /product="enoyl-CoA hydratase/isomerase family protein"
                     /protein_id="WP_153034318.1"
                     /transl_table=11
                     /translation="MNVLLTEDHGPVRVLTLNRPDKLNALDTALTRALGDALAVADREA
                     RAVVLTGNGRGFCAGADLGEFSSLTPDQPDAVLERAALTARLQTQMQGMSVPVVAAVRG
                     AAVGGGAGLAIGADMTVAGTDLKFGYPELKHSIVPALVMTGLVRHLGRKLAFELVSTGR
                     LLTAAEAAEHGLVNRVVEPDDVVEVALEIARRWAEVEPRAIAAAKDLFYRVADLPTEAA
                     MRAGRDVNALMRGFRR"
     aSDomain        10957..11580
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_YIM_RS34650_ECH.1"
                     /evalue="6.60E-53"
                     /label="YIM_RS34650_ECH.1"
                     /locus_tag="YIM_RS34650"
                     /protein_end="214"
                     /protein_start="6"
                     /score="171.5"
                     /tool="antismash"
                     /translation="EDHGPVRVLTLNRPDKLNALDTALTRALGDALAVADREARAVVLT
                     GNGRGFCAGADLGEFSSLTPDQPDAVLERAALTARLQTQMQGMSVPVVAAVRGAAVGGG
                     AGLAIGADMTVAGTDLKFGYPELKHSIVPALVMTGLVRHLGRKLAFELVSTGRLLTAAE
                     AAEHGLVNRVVEPDDVVEVALEIARRWAEVEPRAIAAAKDLFYRV"
     gene            11652..12839
                     /locus_tag="YIM_RS34655"
                     /old_locus_tag="YIM_34845"
     CDS             11652..12839
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1189: L-carnitine dehydratase/bile acid-inducible"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020667402.1"
                     /locus_tag="YIM_RS34655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YIM_34845"
                     /product="CaiB/BaiF CoA-transferase family protein"
                     /protein_id="WP_153034319.1"
                     /transl_table=11
                     /translation="MTGSTGPLDGITVLDFSRVLAAPLATQILAELGATVVKVERPGTG
                     DETRGFEPRLPHGESGYFFAFNRGKRSVTLDLKDPRGQAVARRLAARADVVVENFLPGT
                     LDRLGLGHAQLSQENPDLVYVSATGFGQTGPDRARKGYDTVFQALSGVMAMTGEPDGPP
                     SKAGVPVADLTSGLWVTIAVLAGLAGRRGRHLDVSMMDVQLSLHALNAARLFALDEDPA
                     RTGTEHPGRVPSAAFQAGDGQWLHISGSDQHWLPLCEVLGLAELASDPLLRDNSGRVEH
                     RDRVMKAMRGAIAQHDRDALVKELRAAGVPVGAVRSVREALSDPHAVARGVVGEFDHPT
                     EGRFPALRTPLRETAGEPTAIGVPPLLGADTDDVLAGLAGLTADEIEGLRAAGVI"
     gene            12841..13593
                     /locus_tag="YIM_RS34660"
                     /old_locus_tag="YIM_34850"
     CDS             12841..13593
                     /NRPS_PKS="Domain: ECH (7-245). E-value: 5.3e-51. Score:
                     165.2. Matches aSDomain: nrpspksdomains_YIM_RS34660_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009076854.1"
                     /locus_tag="YIM_RS34660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YIM_34850"
                     /product="enoyl-CoA hydratase/isomerase family protein"
                     /protein_id="WP_153034320.1"
                     /transl_table=11
                     /translation="MGDRVRLGVTDGIAHVELTRPEARNAVDLPMCTELCEAFEEVDAD
                     EDVRVVLLSAHGPVFCAGADLKERTGKDAAWVRRRRVASFAAYAAIERCRRPVVALVQG
                     AVVGSGGEITLAADFAIAAEGTVFRFPEPHWGTVGATQRLQRAIGKRKAKELLFTNRPL
                     DAADALRLGIVTQVVAPDALASTGAETARDIAKAPPLAIALTKRAVDLGGETDLDRGIR
                     IEMSAIEQCLADGGWRDGVARFTNGDGR"
     aSDomain        12862..13575
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_YIM_RS34660_ECH.1"
                     /evalue="5.30E-51"
                     /label="YIM_RS34660_ECH.1"
                     /locus_tag="YIM_RS34660"
                     /protein_end="245"
                     /protein_start="7"
                     /score="165.2"
                     /tool="antismash"
                     /translation="GVTDGIAHVELTRPEARNAVDLPMCTELCEAFEEVDADEDVRVVL
                     LSAHGPVFCAGADLKERTGKDAAWVRRRRVASFAAYAAIERCRRPVVALVQGAVVGSGG
                     EITLAADFAIAAEGTVFRFPEPHWGTVGATQRLQRAIGKRKAKELLFTNRPLDAADALR
                     LGIVTQVVAPDALASTGAETARDIAKAPPLAIALTKRAVDLGGETDLDRGIRIEMSAIE
                     QCLADGGWRDGVARFT"
     gene            13590..15170
                     /locus_tag="YIM_RS34665"
                     /old_locus_tag="YIM_34855"
     CDS             13590..15170
                     /NRPS_PKS="Domain: AMP-binding (18-421). E-value: 1.2e-86.
                     Score: 282.8. Matches aSDomain:
                     nrpspksdomains_YIM_RS34665_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020667404.1"
                     /locus_tag="YIM_RS34665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YIM_34855"
                     /product="AMP-binding protein"
                     /protein_id="WP_194239852.1"
                     /sec_met_domain="AMP-binding (E-value: 1.3e-97, bitscore:
                     326.2, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIPLRTACPLTTHEALARAALLAPDVEAVVTAEERITYGELAAAV
                     GRVRDALVTAGIGRGDRIGLCLGNGPDWVALFLAIGSVGAIAVPVNTRFTAGEVHYTLS
                     HAKVSTLFTADRVLSSDFAGMLGELDLPELKSIVMLGSDVPAYATSWESFLEAGSGRNA
                     EPTAVADDLLLVQYTSGTTARPKGVLLTHRSMCADAFFSGMRMGLRPGDRFHSARPFFH
                     VAGSTLSVLASVQHATTLVTMPKFDAAEALRLLEAERCTHFSGNDTIALLLLNHPGRTR
                     RALCLRGAWVAASPTVIRRVIDELGARECVAGYGLSEASPNVAQSAWWEPEEVRAAGAM
                     AVEPGVEVRIRDFDDRRDCGPGEPGSILVRGWNVMRGYLDDPVKTAEAIDQDGWLSTGD
                     IGSLDASGRLHFSGRTKDIIRVGGENVAPADIEDVLHRHPLVRQAAVVGVPDERLLEVP
                     FAFVVLTEPGITPDELLAWARSRMAGFKVPRYLRVVDGFEGIGMTASSKVQKNRLAEHA
                     RALLSEVAS"
     aSDomain        13644..14852
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_YIM_RS34665_AMP-binding.1"
                     /evalue="1.20E-86"
                     /label="YIM_RS34665_AMP-binding.1"
                     /locus_tag="YIM_RS34665"
                     /protein_end="421"
                     /protein_start="18"
                     /score="282.8"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="AALLAPDVEAVVTAEERITYGELAAAVGRVRDALVTAGIGRGDRI
                     GLCLGNGPDWVALFLAIGSVGAIAVPVNTRFTAGEVHYTLSHAKVSTLFTADRVLSSDF
                     AGMLGELDLPELKSIVMLGSDVPAYATSWESFLEAGSGRNAEPTAVADDLLLVQYTSGT
                     TARPKGVLLTHRSMCADAFFSGMRMGLRPGDRFHSARPFFHVAGSTLSVLASVQHATTL
                     VTMPKFDAAEALRLLEAERCTHFSGNDTIALLLLNHPGRTRRALCLRGAWVAASPTVIR
                     RVIDELGARECVAGYGLSEASPNVAQSAWWEPEEVRAAGAMAVEPGVEVRIRDFDDRRD
                     CGPGEPGSILVRGWNVMRGYLDDPVKTAEAIDQDGWLSTGDIGSLDASGRLHFSGRTKD
                     IIRV"
     CDS_motif       14112..14165
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_YIM_RS34665_0001"
                     /evalue="3.10E-07"
                     /label="NRPS-A_a3"
                     /locus_tag="YIM_RS34665"
                     /protein_end="192"
                     /protein_start="174"
                     /score="22.8"
                     /tool="antismash"
                     /translation="VQYTSGTTARPKGVLLTH"
     CDS_motif       14670..14753
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_YIM_RS34665_0002"
                     /evalue="7.90E-08"
                     /label="NRPS-A_a6"
                     /locus_tag="YIM_RS34665"
                     /protein_end="388"
                     /protein_start="360"
                     /score="24.7"
                     /tool="antismash"
                     /translation="PGEPGSILVRGWNVMRGYLDDPVKTAEA"
     CDS_motif       14820..14885
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_YIM_RS34665_0003"
                     /evalue="6.60E-03"
                     /label="NRPS-A_a8"
                     /locus_tag="YIM_RS34665"
                     /protein_end="432"
                     /protein_start="410"
                     /score="9.4"
                     /tool="antismash"
                     /translation="FSGRTKDIIRVGGENVAPADIE"
     gene            15167..16120
                     /locus_tag="YIM_RS34670"
                     /old_locus_tag="YIM_34860"
     CDS             15167..16120
                     /EC_number="1.13.12.-"
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010226968.1"
                     /locus_tag="YIM_RS34670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YIM_34860"
                     /product="nitronate monooxygenase family protein"
                     /protein_id="WP_153034321.1"
                     /transl_table=11
                     /translation="MITTRVTELLGIDLPIVQAGMSWASSSSALPLAVSNAGGLGVVAA
                     GPMRLPDLARTLDEMAAGTERPWAVNLPLYRRDADAVIDLLLDRRPPVLIASQGGPRRY
                     LAEFHAVGTRCLHVVAGTTHARKAADAGVDALVVVGAEAGGHPPPAMVTTQVLVRAVVR
                     AVPEVPVIASGGVADGAGLAAMLALGAGAAQFGTRFLASVEASVHDDYKAAVLGAGVDG
                     TRTVGRGLGVIRSVANDFTERMLDLEHSGAEEALRRKTFEASSLKDAALLGDVTEGKVE
                     AGQSAGLIDAVLPAAEIVARLVDEYRAARDALPPVD"
     misc_feature    complement(16122..16138)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.17"
                     /tool="antismash"
     gene            16182..16679
                     /locus_tag="YIM_RS34675"
                     /old_locus_tag="YIM_34865"
     CDS             16182..16679
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020659118.1"
                     /locus_tag="YIM_RS34675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YIM_34865"
                     /product="nuclear transport factor 2 family protein"
                     /protein_id="WP_153034322.1"
                     /transl_table=11
                     /translation="MDIADLAALEEIKRLKYRYLRCVDTKDWDDLADALTEDAVADYGT
                     PTYGKPLLLTGREAILEFMRTTLGPEIVTTHFASQPEIDIDGDRATGTWAFQDLVIATE
                     HRVVISGAAFYEDVYRRGEDGRWRIAHTGYQRTYETTHSLDDLPSFRLTANRWAPAPTA
                     AD"
     gene            complement(16717..17388)
                     /locus_tag="YIM_RS34680"
                     /old_locus_tag="YIM_34870"
     CDS             complement(16717..17388)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005163586.1"
                     /locus_tag="YIM_RS34680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YIM_34870"
                     /product="pyridoxamine 5'-phosphate oxidase family protein"
                     /protein_id="WP_370468906.1"
                     /transl_table=11
                     /translation="MRLLAWSGHGELIELGEPVTRVLRDEAELRDLVREPHRLVAEKHI
                     DHIDPESRRFIEASPFFLLATSDAEGNCDVSPRGDPAGSVLVLDEYTLAFADRKGNRRL
                     DNLRNILAQPRVGLLFVVPGIGDTLRVNGTAQVVAEAPYLPRMAVEGVVPVLAVEVRVR
                     ELFSHCSKAFLRSKLWDPASWPERGDVPTAGQLARSQSGTRIPARMLDAALRAEAKHNQ
                     Y"
     gene            17487..18257
                     /locus_tag="YIM_RS34685"
                     /old_locus_tag="YIM_34875"
     CDS             17487..18257
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1195: IclR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005463211.1"
                     /locus_tag="YIM_RS34685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YIM_34875"
                     /product="IclR family transcriptional regulator"
                     /protein_id="WP_228004204.1"
                     /transl_table=11
                     /translation="MTKDKTSGTEVAGRVADVLLLFAAGPKYRGVSEISRELDVSKAVV
                     YRILQSLVSREMLGTDPGVAGYRLGPAAVALGASALRRFDLRVAAAPVLRRLREETGET
                     TTLSGLLGDQRVYLEQFESEREIKMTVELGKRFPLHAGSSGKVILANLPADRREALLAA
                     PHDALTERTIVDDAELRAELDRVAEDGVAVSLGERQAGAGSVAAPVFGPNGEVQGAISV
                     CGPEYRFTPDLVERYRELVRVAADEITRAPLAAH"
     gene            complement(18258..19733)
                     /locus_tag="YIM_RS34690"
                     /old_locus_tag="YIM_34880"
     CDS             complement(18258..19733)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Amidohydro_1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019930213.1"
                     /locus_tag="YIM_RS34690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YIM_34880"
                     /product="dihydroorotase family protein"
                     /protein_id="WP_153034325.1"
                     /sec_met_domain="Amidohydro_1 (E-value: 1.5e-10, bitscore:
                     40.0, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATTELLVRNVRVVRPEDTADADGVPELLDIAVNDGTITRVAPGL
                     DPADAATVVDGRGLLAFPGVVDAHQHWGIYNELGTDTRTESRASAQGGVTTALTYMRTG
                     QYYLNKGGSYREFFPEVLAAADGNAYVDYAFHLAPMMAQHIDEIPYLVEEHGVTSFKIF
                     MFYGSHGLHGRSSSQSDFLMIPPEERYDLAHFEFVMRGIQRAREQLTDYADHLSLSLHC
                     ETAEIMTAYTKLVEQDTSVSGLRAYSRSRPPHSEGLAVTIASYLAHETGLPNINLLHLS
                     SEKALDAALRMAKTFPQVDFRREVTVGHLLADVDTASGIGGKVNPPLREREDVEALWGH
                     VLAGEVDWVVSDHACCRDELKFGEDRDDVFLAKSGFGGAEYLLPGLVGEGVKRGLSLQH
                     IARLTSWNPARRYGLLRKGTIAEGYDADFALVDPDVSWTVRAADSESTQEYTPFEGFPM
                     TAKVTDTFVRGHHVYTDGKVTGEPVGRYQRRGR"
     misc_feature    complement(19708..19722)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.27"
                     /tool="antismash"
     gene            complement(19740..21101)
                     /locus_tag="YIM_RS34695"
                     /old_locus_tag="YIM_34885"
     CDS             complement(19740..21101)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005463208.1"
                     /locus_tag="YIM_RS34695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YIM_34885"
                     /product="FAD-binding protein"
                     /protein_id="WP_153034326.1"
                     /transl_table=11
                     /translation="MSEGPDLVVAGAGGGLAGALRAAELGLSVLVVEASEHFRRGNNTS
                     MSTAMFPGAGSRWQRESGVGDSPAGFAADIMAKTHGQAEPRLTRTLAEVSAPLVEWLAD
                     SLRLPLSLVTDFNYPGHSVPRCHSIPGRHGSGVVDHLARLVTEHPGIDLLVPAKLVDVL
                     TGVDGAVRAVVVRDPSGAEEEIPTRAVLLATNGYGADGELVRRHLPEIADALYQGSDQS
                     LGDALRIGEKLGAATGFLDAYQGHGAVAANAGTLVGWATIIHGGILVDLGGRRFGDETR
                     GYSEYAAELAARPGGTGWIVLDEVIFEQCQPFQDFRDTVAAGAVHFADDIPSLARVTGL
                     PEEALAAELGTAAAIARGERADEFGRTNWERPLAPRYAAVRVVPALFHTQGGLLVNENA
                     AVVDAADRPIPGLYAAGGAAAGISGHGADGYLPGNGLLPAFGLAYLAANAIAKE"
     gene            complement(21098..21736)
                     /locus_tag="YIM_RS34700"
                     /old_locus_tag="YIM_34890"
     CDS             complement(21098..21736)
                     /GO_function="GO:0036361 - racemase activity, acting on
                     amino acids and derivatives [Evidence IEA]"
                     /GO_process="GO:0008152 - metabolic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020417742.1"
                     /locus_tag="YIM_RS34700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YIM_34890"
                     /product="aspartate/glutamate racemase family protein"
                     /protein_id="WP_153034327.1"
                     /transl_table=11
                     /translation="MRALAITPIHLPPEEIGRRQSRYDRLAPPGLRIELRDVGPEAPSA
                     LDTDGSVRDSERAVAAALAAADGDWDVAFPDCVLDPAVPDRVAIGPRPVHGLLKLSASH
                     LAAKGERFGAVVRNQAIGAELRWRLAAYGLTSNLVGVRVLDLPFEAIADTAAWNAALGE
                     AVRDLADQGATAVLNGCSAVDVVPADLPARVVDPTALALTVLMAEGECA"
     gene            complement(21736..23031)
                     /locus_tag="YIM_RS34705"
                     /old_locus_tag="YIM_34895"
     CDS             complement(21736..23031)
                     /GO_function="GO:0016829 - lyase activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005463196.1"
                     /locus_tag="YIM_RS34705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YIM_34895"
                     /product="MmgE/PrpD family protein"
                     /protein_id="WP_228004205.1"
                     /transl_table=11
                     /translation="MSKEHVDELGAWVSGLSTLDSAPALDRLGLVLLDVLGVMALGTNQ
                     PEHRALYAAWRPPAGPAPLIGTGELVSVDAAAWLGAMALVSRELDEGNKYAKGHPAAHG
                     FPAVLALAAELDSSGADLAAALLAAYEVAARFGRATKLRPGTHPHGNWGVPGAAAGCAR
                     LLGLDADATAAAIDTAAGMPIAGHFASATTGNPVRDAWLGASNVSGLVAARMAAAGIAR
                     NTGTAALSLGELLGSLDADELTAELGTRWDITLGYFKRHAACSFTHPAVDAMLTLRGPE
                     IESVLVETHALGAGLSGVDWDNRLSAMFSTPFAVATAALTGAVGPAAPLDDPAVRDLAK
                     RVRLAEAADLTARLPGERAARVTVTYADGSTRTAEVPNPIGDADHHPLGEAEVIALLGP
                     WLPDGAVAFCRDLPRLPATGAALRELDGKEPS"
     gene            complement(23028..23729)
                     /locus_tag="YIM_RS34710"
                     /old_locus_tag="YIM_34900"
     CDS             complement(23028..23729)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020417740.1"
                     /locus_tag="YIM_RS34710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YIM_34900"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_153034328.1"
                     /transl_table=11
                     /translation="MLTLDQVCAGYGRMRILHEIDLHLGEGEIVALVGANGAGKTTTLR
                     SICGQLRPSSGTITFDGRPIAGRRPDQLVRDGLVHVPEDRALFGTLTVEENLRMGAWTR
                     TAEQAEASLREVHELFPILAERGTQLAQTFSGGQQQMLAIARALMAGPRLLMLDEPSTG
                     LSPKLTWTMLEAIRRIRDTGVSVLLVEQNAKQALAIADRAYVLESGSAVLSGTGAELAD
                     DARVRKAYLGL"
     gene            complement(23716..24450)
                     /locus_tag="YIM_RS34715"
                     /old_locus_tag="YIM_34905"
     CDS             complement(23716..24450)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020417739.1"
                     /locus_tag="YIM_RS34715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YIM_34905"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_228004206.1"
                     /transl_table=11
                     /translation="MSLVRISGVGKSFRGLRALSDVDLAVDEGEIVGIIGPNGAGKTTL
                     FNVVCGALKPDTGTVELAGRDITGASPDRIARAGMVRTFQLMRPFASMTVVQNVSLAAQ
                     HRRMPAKRLYEHSLAVVERVGLGPWAHRLATELPTAGLKRLELARTLAMRPRVLLLDEV
                     LAGLVPAEREPVLDLLAELREQDGTTLLFIEHIMAAVMRLSDRVLVLDQGRVLATGSPE
                     EVTSDPRVIDAYLGEEPARADS"
ORIGIN
        1 acgatccagg actgcggccg attttggctg ggtgaccacc aaaacgactg cccggaaccg
       61 gcggcggtgc tgctgaccgg caccgagggc ggcgaccggc tgctctgcgc ggcgcacgcc
      121 gagcgagccg gccgggaact cgccgagcac caccccggca cgcggtacga ccaagcgggc
      181 taaggctgtc cattgtggac actttcaccc cggtcgcgag gatgatcggg caacgtcccg
      241 cgaccgctcg ggcacgctcc gcacccggct gttgtcccgg cggccgggct tgccttcact
      301 acgaacatgg ccgatcccct gttcgccgag aagcgcgggc cggtcgacgt ggccaccgga
      361 gaggtggtac tggcacaggc cgatctcacc ctcaccggcc gcccggacct ggtactccgc
      421 cgcacccatc tctcgtccta tcgcgccggc cgctggttcg gcgcgtcctg ggcgtccact
      481 ttggaccagc aactgctggc cgacgagctg cacctgcgcc tgttcaccgc cgacggccgg
      541 gtgcggtgtt acccgcaccc caccggcgcg gacgccgtgt tcccgctgac cggtcatggc
      601 cacccgctac gacggcacgc cgacggcgac cgcgtcgaaa ccccggacgg cgtcctgctg
      661 ttcgaaccgg ggcacggccc cggcggccgg cgcctgctgg ccatcgagca ccctggcacc
      721 ccaccggcca ccatcgagta caccgacggc ggcgcgcccg ccgtgctgcg cggcgccgct
      781 ggccaggagg tccggttcac caccgcggac ggccggatca ccggcatcga cgtcgtcggc
      841 gacggcatca ccaccgccgt ggtgcgcttc ggttacaaca agctcggcca gctcgtccag
      901 gtggccaatg ccggtggccc gccgatgttg ctcgactacg acctcagcga ccggctcatc
      961 ggctggcagg accgcgtcgg cacctggtac cgctacgcct acgacgccgg cgggcgctgc
     1021 gtgcggacca tcggcgccga cggcttcttc tccggcgcgt tcgcctacga cgacgcgcgc
     1081 cgcgccacgc tgcacaccga cgcgctcggc cacaccaccg agttccggtt cgacgaagcg
     1141 ggcaggctca ccgaggaggt cgacccgctc ggtggccgcc acggctacag ctgggatcag
     1201 cggggcaggc tgttctcacg caccgacccg ctgggccgga ccacgctgtt cacctacgac
     1261 gaggcgctga ccggcctcat caggccggac ggctcggtgg tctcctactc cccggacacc
     1321 ctcgaagtgt ccactgagga cgtacgacgt tcctacgctt cagtgcccga tccgccggcc
     1381 gagccggtcg gggtcgccgt gccgtggcgc gccaccgggc cggacggccc gttcgccgac
     1441 gagccaccgg acgacgaccc gtccgccgaa cgcgacgcct tcggcaggcc acgcaccgcc
     1501 cggacggcgt ccggcgccac ggtcgggctc ggctggaccg tggccgggca ccgggcggtg
     1561 cggcagggac cgctgggcag gcgcgacgtg tggcggttcg acgccgaggg caacgcggtc
     1621 gagcaccgcg acgcggccgg gcaggtctcg cggcgacgct acggccggtt cgggctgctc
     1681 atcgccgaga tcgacgccga cggcgggcgc accacctaca cctacgacgg ccgggcgcgg
     1741 ctgacctcgg tgaccaatcc ggtggggctg acctggcgct acgcctacga tccggcgggg
     1801 cgcctgatcg aggaggagga cttcgacggc cgcctgatca gcttcgacta cgacgtggcc
     1861 gggcagctga cccggctgac caacggcctc ggcgaggtca ccgagttccg ctacgaccgg
     1921 ctcggcaacc tggtggagca gcgcacggcc gaggacgtca ccacctacgc ctacgacccg
     1981 ctcggccgcc tggtgcacgc ggcgaaccgg gattccgtgc tggagataag ccgggacgcg
     2041 ctcggccggg tgctcatcga gtcggtcaac ggccacgagg tgcgctggcg ctacgacgac
     2101 gaaggcacgc accggcgcac accgtccggt gtggacagtt cgtggcggcc ggacagcctg
     2161 gccctcgccg ggcacgagat ccggatcgag cgcgacgcgg ccggccggga acgcacccgg
     2221 ttcgtggacg ggctgcgtgt gctcgcgcag cggttcgacg ccgaggacca gctcgtcgag
     2281 caggtgctcg cccacggtga gcaggtgctg aagaagcgcg agttcaccta ccggatcgat
     2341 ggccggctga tcgccgtcga cgactcggtg ggcggcccga cccggctccg gctcgacgcg
     2401 ctcgggcggg tcaccgagag caccggcccg cgcggcaccc ggcggtaccg gtacgacgcc
     2461 gcgggcaaca tcaccaaggc cggtgcggaa acccggacct accaccgcaa ccagctgctc
     2521 gaagcgggcc gcacccggta caccgcggac cggcagggcc gcgtcaccga gcgctggtcg
     2581 gccgatggtg cctggacctt cacctgggac cggctggacc ggctcaccga actgaccacc
     2641 ccggacggcg cgcggtggac ctactcgtac gacgcgctcg gcaggcggtt cgcgaagcag
     2701 cggtgggtgt ccggcgcggt ggtggaggaa acgcggtacg cctggagcgg cacggagatc
     2761 gtcgaacggg acggcacgga ttcggtggtg acctgggcgc acgaccgcga tggccggctg
     2821 gtggcccagt cctcgccagg cacgttcagc tcgatcgtga ccgacgccga cggaagtccc
     2881 accgaactgc tggacggcga tggcacgctg cgctggcagt cctgcgcctg ggacgccccg
     2941 tgctgggacg ccgatgcgga aagcgggctg caccaccact tcgaccggta cttcgacccg
     3001 ggcatcgcgc ggtacctcag ccaggatccg ctcggcctgc ggccaggccc caacccggtc
     3061 gcccgccacc cggcccaggc acgcgggtcc gccagtgccg tcccgcatcg gcccgggtcc
     3121 gggtaccacc gcggggtcgc cgtccacccc cggacgggcg gcggcgggta gggtcgcgga
     3181 catgggagtt gccactgacg agcgccaggc gttgtgcggg ctgttcgagg agttggggcc
     3241 cgacgcgccg acgttgtgcg aggggtggcg caccagggac ctcgccgcgc acctggtcgt
     3301 gcgcgagcac cggctcgacg cggcggccgg gatcctggtg ccgttcctcg cctcccacac
     3361 cgaatccgtc cagcggcgtt atgccaccga gccgtgggag aagctggtcg accgggtgcg
     3421 ctccggcccg gccttgctct ggcccacccg gctgcccccg ctcaacgaac tggtcaacag
     3481 cgccgagttc ctcgtccacc acgaggacgt gcgccgcggc caggaaggct gggaaccccg
     3541 cccggccgag gccgcgcggg acgccgccgc ctggcgttcg gtgcgggcga tcgccaagct
     3601 caccctgcgg aactcacccg tcggagtgct gctgcgcgcg cccggccacg gtgaggtggt
     3661 cctcaagggc cccgaccccg tcacgctcac cggcggaccg ctggaaatcc tgctcttcgc
     3721 cttcggccga gacgccgtac gcctcgaatt cgacggtgaa ctcaccgcca tcgcccgact
     3781 gaagtcactc agccgcggtc tctagctttc cgcgagtgcc tgtgcggcgc gcaggaaagc
     3841 cgcccggtcg gtggcgggca ggccggcgag cagttcgtcc tcgtgcgcct ggatctgctt
     3901 ctgcgcgccc cgccgccggg cgcgtccctc gtcggtgatc gccagcactc gcacccgccg
     3961 gtccgcgggg tccgggtccc ggctgatcag cccggcttcc tgcagttcgt ccagcgtccc
     4021 gatgatccgc gtcttgtccg cgccgatcgc gcgcgcgagc gcggcctgcg tgcgcaccgg
     4081 gccgtcgtcg agcgcgctca gcaccacgta accccacatg ctcaagccgt gctccgccag
     4141 caccggcgcc tcggccgcca tcagccggcg catcagtccg ccgagcatcg ccgccaggtc
     4201 cggccgggtg cgctccgcca tgcgctgacc ctaacctcct tgaccaaccg taagcatgtg
     4261 tagatgatgt gcacatgcct atcaacgagc tccgcatcct cgacgctctc gccaccagtg
     4321 ccagccttga tctcgtcgac cgcgtcgaac ccgcggacct ggccaaaccg acaccctgcg
     4381 aggcctggac cctgcacggc ctgctcgcgc acatgaccac ccagcacctc ggcttcgccg
     4441 ccgcggcggg tggtgacggg gacccggaga actggaagct ggtccccctc ggcgacgacc
     4501 ccgccgccac ctaccgcgat tcggtgaaca aggtgctgaa cgccttcgcc gccgacgaca
     4561 tcgccgaccg caagttcccg ctgcccgagt tcaccaccga gttcaccttc accgccgagc
     4621 aggcgatcag cttccacttc gtcgactacg tggtgcactc ctgggacgtg gcccgcacgc
     4681 tcggcctgcc gctcaccttc cagcgggagg tgctcgacgc cgcggcgcgc atcgccgaga
     4741 tcgtcccgga tggacagtca cgcctcgctc ccggcgcggc cttcggtccc gccgtcgccg
     4801 ccgacggact gtccggtttg gaccggatcg tggcgctgct cggccgctcg cccagctggg
     4861 cgccgaacgg ttcccggtga aggtcggagg gctgtcgcga gagcggcgaa ggcgcacgta
     4921 acaacgagcc cggcccagcc gggcagcggg aagtagcccg ccgaagggga atagtccgcc
     4981 agcacctgcg ggaactcttc ggcggtctgc agcacggcga acccggcggc gggcgtgacg
     5041 cgcagcagcc aatctcccac ttcggcgggc agcacgagcg ccaggacgta cggcaccacc
     5101 gtcaccgccg ccgtgatcag ccaggaccgc aaagcatgcg ccagcaccgc gatcgccccg
     5161 gtcagcaagc cgacaccgag gatcacccgc acccagatga gcgcatcgac cggaagcacg
     5221 gtgccaccgg cgatccgcgt ggccaacacg cctgccggaa gcgccagccc ggcggcgagc
     5281 agtccggcga aaaaccccgc accgccgaca gcgacaacgc gtccgccccg aaaccggccc
     5341 gcgaaagcga gaagcccagt accagggcgg aacctggcgg ccaccacgat caccaccaga
     5401 atcagcacgg gcagcccgag caacgctctt tcgagcgagg ctccgccgat cgtgccgacc
     5461 gggccgacat ccccggaacc ggtcaccgtg accacgccgt tctccagggt gagcccgggt
     5521 gcccggtgca ggcgttccca gtcggtggtc cccatttcgc cgatcgtgct gccggtccag
     5581 tccacctcgg ccgcaccggt cacggtgatc tggtcgaagg atgcggtcgc ctgggtgaac
     5641 cggacctggg caccgccctc cccgctcagg gtcaggtcac cgggcgaagc ggtgaagaat
     5701 cctacttgga cagtggcggg caggccctcc agcacggcgg tgccgaccgg tgtccagctg
     5761 aggccgtcgg ccgactcgta accggtgatc gtgtcgccgg accgggtcag ccgcagccag
     5821 ctcgcaccgg cgacgctgcc cgcggtgtcg tgctcgtagt cgtactgcat ccgcacaccg
     5881 tggctgccgg tgaacatcag cgcggcgtag gacgaacccg gggtgagccc gtccttcacc
     5941 atcaggcccg ccttcgccca cggcaccagg ccctcggtga tccggtcgtg gtccggtggc
     6001 ggatacgtga tcaccccgga catcgaggcg agccgggcag tgacgctgcc gtctgtcccg
     6061 agtggacggt gcgcgaaggc gaactggtcg ctgaccgcgc gtccgtccgg tcccaccgga
     6121 tcgctcgggc aggcgacctc gaccgtgccc acactgcacg tcgacctatc ggccaccgcc
     6181 gggagcacgc ccgccagtac ggtcagaagc acggcgccga gtaacgcgaa gagttgtttt
     6241 cgttgcacgg ctccggtcta cgggccgggc cataacaccg gccgaaccgc cgctgtcacg
     6301 ccgttgttag gtcccgccgg tcatgctggt gccatgggca agccacaacg aacggtccgg
     6361 ctgcgcttca ccgttctcta cgcctcgctg ttcctcgtct ccggcatcgg cctgctggtg
     6421 ctgaccaacc tgttcaccgt caccgccccg gcggacttcc ccgagcagct ggaggtggtg
     6481 cgggcgcggc agttgctggc gggctcgctg atcgcgctcg gggtgatgct ggtggtttcg
     6541 gtgctgctgg gccggttcgt cgccgggcgg gtgctgcgcc cgctgcgcac catcaccgcc
     6601 gcgacccggc gcatcaccgc cgagaacctg cacgagcggc tggccgtgcc cggtccggcc
     6661 gacgaggtca agcacctcgc cgacaccatc gacgacctgc tggaacgcct ggaggcgtcc
     6721 ttcgccgcgc aacgccggtt cgtcgcgaac gcctcacacg agctgcgcac cccgctggcg
     6781 accatgcgcg cttccctgga cgtcgcggag gcgaagccgg aaccgcggct cgaccaccag
     6841 ctggccgagc gcttccgcac cgaactcgac cgggtcgacc agttgctgga gggcctgctc
     6901 gcgctggccc gcgtccagca cggcgccttt gccgaccagg gcgaagtttc cctgcgcgac
     6961 ctggtcaccg aagcgctccg cgcccgcgag accgacatcg cggcgaagga cctcaaggtc
     7021 gagcgggagc tgggcgaatc gcgggtccac ggcagcccgg cgctgctgtc gcggctggtg
     7081 gcgaacgtgc tcgacaatgc gatcgtgcac aacgaacgcg gtggctggat ccgggtcacc
     7141 accggcgaca acgggttcga ggtggagacc ggcggcgcgg tgctcgacca ggccgacgtg
     7201 gaccggctcg ccgacccgtt ccggcggctc gccgccgatc ggaccacttc ggacggtggc
     7261 agcgggctcg gcctgtcgat cgtcgcggcg atcgcggagg cacacgggcg ccgtctccgg
     7321 ctgaaagcgc gctctgacgg cggattgcgg gtgacggtat gagggtgctg gtggtcgagg
     7381 acgcgcgggc gctcgccgac gtgatcgccg aagggctgcg ggaccagggc atggccgtcg
     7441 acctcgcgta cgacggccac accgcggcgg ccaagctgga cctccacccg tacgaggtgg
     7501 tggtgctcga ccgggacctg cccggcatcc acggcgacgt gctctgcggg ctgatcaccg
     7561 agcgcgagga ccgggcgatg gtgctgatgc tgaccgcggc cggctccccg gtcgagcggg
     7621 tcagcgggct caccctcggc gccgacgact acctggccaa gccgttccac ttccccgaac
     7681 tggtgctgcg gatccgggcg ctggcccgcc gccgcccgtc cgcccgcgcc cggatcctgc
     7741 gcgccgcggg catcgaactc gacccgatcc ggcgcaccgc cacccgcgac ggccgtccgc
     7801 tcgacctctc ggtcaaggag ttcaacctgc tcaccgcgct gctccaggcc gggcccgcct
     7861 ggagcagcac cgaggaactg ctggaccggg tctgggacga gcacaccaat ccgttcacca
     7921 acacggtcac cgtgaccatc gggcgactgc ggcggaagct cggcgatccg ccggtgatca
     7981 ccacgctgcc cggcgccggt taccggctca ccgatccggg cgggtctcct tgagatcgcc
     8041 cgccttcacc ccggtcagca gcaggaccac ggcgagcagc acgatgccgg cgctgatctg
     8101 caggccgagc gaaaggctgc cggtggccga ctggatgaag ccgagcagcg agggcgaggc
     8161 ggccgcggcg aaggaaccca tcgaggtcac cacggcgatg ccggtggccg cggcccggtc
     8221 ggtcaggtag atcgacggga tcgagtagaa caccgtcagc ccggagtagt gggccgccgc
     8281 catgatcgcc agcagcagga tcaccaccac cacgttgccg ccggagaccg acagcgccag
     8341 catcgcgaac gcggccacga tccagctggt ggccgcgtgc cagcggcgtt ccagcgtccg
     8401 gtcggagtgc cgcccgacca ccagcatcac cacgatgccc agcagcggcg ggatggccga
     8461 gaacagcccg aggttcagca cgtcgccgac cccggcgtcg gcgatgatcc gcggggtcca
     8521 gtacgaaacc gcgttcgcca gcgtgtaggc accgcaggca cacaggccga ggatccacac
     8581 cttggtgtcg cgcagggcga ccagcagtcc cccgtgtgct tcggcatggt ccgccacgtc
     8641 gcccttgcgt cgccggtcgg cttccaggtc ggcgcgcacg gcggccttct gcgcgggcgt
     8701 gagccacttc gcctgctcgg gttcgtcggc gaggaagaac agcaccagca cggccagcag
     8761 gatcggcggc acgccttcga gcaggaacag ccactgccag tcggccagcc cgccgacccc
     8821 gccgaaggtg tgcatgatcc agccggacac cagcgagccg agcacccccg aaaccggcac
     8881 gccgatgaag aagaccgcgg tcatccgggt gcggcgggcc gaggggaacc agcgcgagag
     8941 caggtagagc gcgccgggga agaacccggc ctcggtcacg cccagcagga acctggccag
     9001 gtagaaggtg agttcgtcct gcacgaacat ggtcgcgacg gtcaccacgc cccacgaggc
     9061 catgatgcgg acgagcgtct tgcgcgcgcc gatccgcgcc agcagcgcgt tgctcggcac
     9121 ctcgaacagg atgaacccga cgaagaacag ggtcacgccg aggccgtaga ccgcgggccc
     9181 gaagccgagg tcgcgcttga ggccctgctg cgcgataccg atgttggtgc ggtcgatgaa
     9241 gctgaccacg taacagatca ccagcagcgg catcacgcgc aacgcgatgg tccggtaggt
     9301 cgccggccgg tcgacggcgg cgtccggccg ttcggtggcg gatgggggtt cggccacgac
     9361 tgcgactcct ttgtccggcg ggcggtggcg cgatcagtgt tggcgtcagg tgttgagttt
     9421 gtcaacacct gtgaccggcc agctaccatc tgcccatgag cgaacgcgcg gacggacgcg
     9481 acctggtacc gatctccgca ctcctgtcct accgcctctc ccgcacctcg tcggcgatgt
     9541 cgaggagcgc ggcgctgcgc tacaagcgcg agttcgacgt cagtctcggc gagtggcgcg
     9601 cgatcgcgct catcgcggcc gacccgacgc tgaccctgaa ccggctcgcc cgccgggccg
     9661 gactggacaa agcgcagatg agccgggtgg tcagccggtt gaccgagcgc ggactggtga
     9721 accggacggc gggttcgggc cggacgtcgc agctcgcgct gaccgaggag ggcacccgcg
     9781 tctaccgcgg cctgatcacc gcggcgaacg agcgcgacgc ggccttcctg gcgatcctgt
     9841 ccgacgagga ggccaccgtg ctgcagagcg cgctggacaa gctggccgag ctggcgctga
     9901 ccgtcgagca acgtgagcgc gcgcacgccg accagcccta gtgttgactt tatcaacata
     9961 gccgcgtagt tctggagcca ccgaagagga ggtggcccgc ttgcccggct cgacgaccga
    10021 cgccgtcacg atctgcgagt gcttcgcccg tgacgggctc cagcacgaac cggtccccct
    10081 gccgaccgcg accaagatcg cgttgctgaa ctccttcgtg gacaccggtt tccggcggat
    10141 cgaggcgacc agttacagcc atcccgcgcg ggtgcccggt ttctccgacg cctccgaggt
    10201 gctcgcgggc gtcgaccgcc gcgaaggggt cgcgttcaag gcgacctgcc cgaatccgcg
    10261 agcggtgtcc cgcgcgctcg cggacctcga cgccgggcac ggcgcggagg aactcagcct
    10321 gctggtctcg gccaccgaga gccacaccga acgcaacctc cgcaccgatc gcgacggcca
    10381 gtgggcgcgt gtgaccgaga tggtccggct cgccggtggc cggttccgcc tggtcggcgt
    10441 ggtctcggtg gccttcggct gcccgttcga gggtgccgtc gacccgggcc gggtggccga
    10501 ggacgtggcc cggttcgccg aactcggcgc gtcgatggtc accctgggcg acaccaccgg
    10561 cgtggccacc cccggcgcgg tccgcgcgat gttcacccgg ctcggccgtg cacaccccgg
    10621 attgccggtc atcgcgcact tccacaacac gcgtggcacc ggcatcgcga acgcggtcgc
    10681 cgcgctggag gcaggctgcc gccacttcga caccgcgttc ggcggcgtcg gcgggcaccc
    10741 gtcgaccatc agctacggcg ccgggctcac cggcaacgcc tgcaccgagg acctggtcag
    10801 cctgttcgac gcgatgggcg tggaaaccgg gctcgacctc gaccggctgg ccgcggcctc
    10861 ggccgcctgc gaacgcgcgc tcggccgccc gctgcacagc atggtcgccc gcgccggctt
    10921 caacccccag gagaccccgt gaacgtgctg ctgaccgagg accacggccc tgtccgggtt
    10981 ctcacgctga accggccgga caagctgaac gcactggaca ccgcgctgac ccgggcactc
    11041 ggcgacgcac tggccgtcgc cgatcgcgag gcacgggccg tggtgctgac cggcaacgga
    11101 cgcgggttct gcgcgggcgc cgatctcggt gagttctcct cgctcacccc ggaccagccc
    11161 gacgcggtac tcgaacgcgc cgcgctgacc gcgcggctcc agacgcagat gcagggcatg
    11221 tcggtgccgg tggtcgccgc ggtgcgcggc gcggccgtcg gcggcggggc cgggctggcg
    11281 atcggggcgg acatgaccgt cgcgggcacc gacctgaagt tcggttatcc cgagttgaag
    11341 cactcgatcg tgcccgcgct ggtgatgacc gggctggttc ggcacctcgg ccgcaagctc
    11401 gcgttcgagc tggtgagcac cggccgcctg ctcaccgcgg ccgaagccgc cgaacacggg
    11461 ctggtcaacc gcgtggtcga acccgatgac gtcgtcgaag tggcgctgga gatcgcgcgg
    11521 cgctgggccg aggtcgagcc gcgcgcgatc gccgccgcga aggacctctt ctaccgggtt
    11581 gccgacctgc cgaccgaggc cgcgatgcgg gccggtcggg acgtcaacgc gctgatgcgg
    11641 gggttccgcc gatgaccggc tcgaccggac cgctcgacgg catcaccgtg ctggacttct
    11701 cgcgcgtgct cgccgccccg ctcgccaccc agatcctggc cgaactcggc gccacggtgg
    11761 tcaaagtgga gcgaccgggc accggtgacg agacccgcgg cttcgaaccc cgcctgccgc
    11821 acggggaaag cgggtacttc ttcgcgttca accggggcaa gcgctcggtg acgctggacc
    11881 tgaaggaccc gcgcgggcag gccgtggccc ggcggctggc ggcccgcgcc gacgtggtcg
    11941 tggagaactt cctgcccggg acactggacc ggctcgggct cggtcacgcc cagctctccc
    12001 aggaaaatcc ggacctggtg tacgtgtcgg cgaccggctt cgggcagacc ggcccggatc
    12061 gcgcgcgcaa gggctacgac acggtgttcc aggcgctgtc cggggtgatg gcgatgaccg
    12121 gtgaaccgga cgggccaccg tcgaaggccg gggtcccggt ggcggacctg acctcggggc
    12181 tctgggtgac catcgccgtg ctcgccggtc tggccgggcg ccggggccga cacctcgatg
    12241 tgtccatgat ggacgttcag ctcagcctgc acgcgctgaa cgccgcccgg ttgttcgcac
    12301 tggacgagga tccggcgcgc accggcaccg agcaccccgg tcgcgtgccg tcggcggcgt
    12361 tccaggccgg tgacgggcag tggctgcaca tcagcggcag cgaccagcac tggctgccgc
    12421 tgtgcgaagt gctcggcctc gccgagctgg cgtcggatcc cttgctgcgc gacaactccg
    12481 gccgggtgga acaccgcgat cgggtgatga aggcgatgcg tggcgcgatc gcccagcacg
    12541 atcgggacgc gctggtgaag gaactgcgcg cggccggcgt gccggtcggc gcggtgcgtt
    12601 cggtgcgcga ggcgctgtcc gatccgcacg cggtcgcgcg cggtgtggtc ggcgagttcg
    12661 accacccgac cgaggggcgg ttcccggcgc tgcgcacgcc gttgcgcgag actgccgggg
    12721 agcccacggc catcggtgtg ccaccgctgc tcggtgccga caccgacgac gtgctggcgg
    12781 gcctggccgg gctcacggcg gacgagatcg agggcctgcg ggccgcgggg gtgatctgag
    12841 atgggtgacc gggtccggct cggggtcacc gacggcatcg cgcacgtcga actgacccgg
    12901 cccgaggcgc gcaacgcggt cgacctgccg atgtgcaccg agctgtgtga ggcgttcgag
    12961 gaggtcgacg ccgacgagga cgtccgcgtg gtgctgttga gcgcgcacgg tccggtgttc
    13021 tgcgcgggcg ccgatctcaa ggagcgcacc ggcaaggacg cggcctgggt gcggcggcgc
    13081 cgggtcgcct cgttcgccgc ctacgccgcg atcgagcggt gccgccgtcc ggtggtcgcg
    13141 ctggtgcagg gcgccgtggt cgggtccggc ggggagatca ccctggccgc cgacttcgcg
    13201 atcgccgcgg agggcacggt gttccgcttt cccgaaccgc actggggcac ggtcggcgcc
    13261 acgcaacggt tgcagcgggc gatcggcaag cgcaaggcca aggaactgct gttcaccaac
    13321 cgcccgctcg acgcagccga cgcgctgcgg ctggggatcg tcacgcaggt ggtcgcgccg
    13381 gacgcgctgg cctcgaccgg tgccgagacc gcgcgagaca tcgcgaaggc gccgccactg
    13441 gccatcgcgc tgaccaagcg cgcggtcgac ctcggcggcg aaaccgatct ggaccgcggc
    13501 atccgcatcg agatgtccgc catcgagcag tgcctcgccg atggcggatg gcgtgacggc
    13561 gtggcccggt tcaccaacgg agacggccga tgatcccctt gcgcaccgcc tgcccgctca
    13621 ccacgcacga ggcgctggcg cgagcggccc tgctcgcacc cgacgtcgaa gccgtggtga
    13681 cggccgaaga gcggatcacc tacggcgaac tggccgcggc ggtcggccgc gtccgcgacg
    13741 cgctcgtgac cgccgggatc ggccgcggcg accggatcgg gctgtgcctt ggcaacgggc
    13801 ccgactgggt ggcgctgttc ctggcgatcg gctcggtcgg cgcgatcgcc gtcccggtca
    13861 acacccggtt caccgccggc gaagtgcact acacgctttc gcacgccaag gtcagcacgt
    13921 tgttcaccgc cgatcgggtg ctcagctccg acttcgccgg aatgctcggg gaactggacc
    13981 tgcccgaact gaagtcgatc gtcatgctgg gctcggacgt gcccgcgtac gcgacttcgt
    14041 gggagtcgtt cctggaggcg ggctcgggcc ggaacgccga acccaccgcc gtcgccgacg
    14101 atctcctgct cgtgcagtac acctccggca cgaccgcgcg gcccaagggt gtgctgctga
    14161 cgcatcggag catgtgcgcg gacgcgttct tctccgggat gcgcatggga ttgcggcccg
    14221 gcgaccggtt ccactccgcg cggccgttct tccacgtcgc cggcagcacg ctgtccgtgc
    14281 tggcgtcggt gcagcacgcc accacgctgg tcaccatgcc caagttcgac gcggccgaag
    14341 cgctgcggct gctggaggcc gagcgctgca cgcacttctc cggcaacgac acgatcgcgc
    14401 tgctgctgct caaccacccc ggccggaccc ggcgcgcgct gtgcctgcgc ggcgcgtggg
    14461 tggccgcgtc gccgaccgtc atccggcgcg tcatcgacga actgggcgca cgggaatgcg
    14521 ttgcggggta cgggctttcc gaggcttcac cgaatgtggc gcagtcggcg tggtgggagc
    14581 cggaggaggt gcgggcggcc ggggcgatgg cggtggaacc gggggtcgaa gtccgcatcc
    14641 gcgacttcga cgaccgccgc gactgcgggc cgggtgaacc gggttcgatc ctggtgcgcg
    14701 ggtggaacgt gatgcggggc tacctggacg atccggtcaa gacggccgag gcgatcgacc
    14761 aggacggctg gctgtccaca ggggacatcg gctcgctgga cgcgtcggga cggctgcact
    14821 tttccgggcg taccaaggac atcatccgtg tcggcgggga gaacgtggca cccgccgaca
    14881 tcgaggacgt gttgcaccgg catccgctgg tgcggcaggc ggcggtggtc ggcgtgccgg
    14941 acgaacgcct gctcgaggtg ccgttcgcct tcgtggtgct caccgaaccg gggatcacgc
    15001 cggacgaact gctcgcgtgg gcgcgttcgc ggatggccgg gttcaaggtg ccgcggtacc
    15061 tgcgcgtcgt ggacggcttc gagggcatcg gcatgacggc cagctcgaag gtgcagaaga
    15121 accggctggc cgagcacgcg cgagccctgc tcagcgaggt ggcctcgtga tcaccacccg
    15181 ggtcaccgaa ctgctcggca tcgacctgcc gatcgtgcag gcgggcatgt cgtgggcgtc
    15241 gtccagctcg gcgttgccgc tcgcggtcag caacgccggc gggctcggcg tggtcgcggc
    15301 gggcccgatg cgcctgcccg acctggcccg cacgctcgac gagatggcgg cgggtaccga
    15361 gcggccgtgg gcggtgaacc tcccgctgta ccggcgggac gcggacgcgg tgatcgacct
    15421 gctgctcgac cgccgtccgc cggtgctgat cgcgtcgcag ggcgggccgc ggcgctacct
    15481 ggcggagttc cacgcggtgg gcacgcgctg cctgcacgtg gtcgccggga ccacgcacgc
    15541 ccgcaaggcg gccgacgccg gggtcgacgc gctggtggtg gtcggcgcgg aggccggtgg
    15601 gcacccgccg cccgcgatgg tcaccacgca ggtgctggtg cgggccgtgg tgcgcgcggt
    15661 gccggaggta ccggtgatcg cgtccggcgg ggtggccgac ggcgccgggc tggccgcgat
    15721 gctcgcactg ggtgccgggg ccgcgcagtt cggcacgcgg ttcctggcca gcgtcgaggc
    15781 ttcggtgcac gacgactaca aggcggccgt gctcggcgcg ggtgtcgacg gcacgcggac
    15841 ggtgggccgc ggtctcggcg tgatccggtc ggtggccaac gacttcaccg agcgcatgct
    15901 cgacctggag cacagcggcg cggaggaagc cctgcggcgc aagactttcg aggcgtcctc
    15961 gctgaaggac gcggccctgc tcggtgatgt gaccgaaggc aaggtcgagg cggggcagtc
    16021 ggccgggctg atcgacgcgg tgctgcccgc cgccgagatc gtcgcgcgcc tggtcgacga
    16081 gtaccgcgcg gctcgcgacg ccctgccgcc ggtcgactga tttcgcggaa aattagaaca
    16141 cgttcttgcg tcagcggcgg cgggggcgga agctggtgcg catggacatc gccgacctcg
    16201 ccgcgctcga agagatcaag cggctcaagt accgctacct ccgctgcgtc gacacgaagg
    16261 actgggacga cctggccgac gccctcaccg aagacgcggt cgccgactac ggcaccccca
    16321 cctacggcaa gccactcctg ctcaccggcc gcgaagcgat cctcgagttc atgcgcacca
    16381 cgctcggccc ggagatcgtc accacgcact tcgcctcgca gccggaaatc gacatcgacg
    16441 gcgaccgggc gacggggacc tgggcgttcc aggacctggt catcgccacc gagcaccgcg
    16501 tggtgatctc cggggccgcc ttctacgagg acgtctaccg ccgcggtgaa gacggccgct
    16561 ggcgcatcgc ccacaccggc taccagcgca cgtacgagac cacccactca ctcgacgacc
    16621 tgccgagctt ccgcctgacc gccaaccgct gggctcccgc ccccactgcc gccgactaga
    16681 acgggttcca ccttcccggg ggcggcgccg ggccggtcag tactggttgt gcttggcctc
    16741 cgcgcgcagg gcggcgtcca gcatgcgcgc cgggatgcgg gtgccgctct gggaacgggc
    16801 cagctgcccg gcggtgggga cgtcaccgcg ctccggccac gaagccggat cccacagctt
    16861 cgagcgcagg aaagccttgc tgcagtggga aaacagctcc cgcacccgca cctcgacggc
    16921 gagcaccggc accacgccct ccaccgccat ccgcggcagg tacggcgcct cggccaccac
    16981 ctgcgcggtg ccattgacgc gcagcgtgtc gccgatgccc ggcaccacga agagcaggcc
    17041 gacccgcggc tgcgccagga tgttccgcag gttgtcgagc cgccggttgc ccttgcggtc
    17101 ggcgaaggcg agcgtgtact cgtcaagcac cagcacactt ccggccgggt cgccgcgcgg
    17161 ggagacgtca cagttgcctt cggcgtccga ggtcgccagc aggaagaacg ggctggcctc
    17221 gatgaaccgc cgcgactccg ggtcgatgtg gtcgatgtgc ttctcggcga ccagccggtg
    17281 cggctcgcgc accaggtccc gcagttcggc ctcgtcgcgc aggactctgg tcaccggctc
    17341 ccccagttcg atcaactccc cgtgccccga ccacgctagc aggcgcaacc cggccgaacg
    17401 taccgctggg cggaacatgt cagcttgacc gcatgattgt cacgagtcac actggggatg
    17461 tcgttcctct gaaagaaaca gggctcgtga ccaaagacaa aacctccggc accgaagtgg
    17521 ccgggcgcgt cgccgacgtg ctgttgttgt tcgccgccgg gccgaagtac cggggcgtca
    17581 gcgagatcag ccgcgaactc gacgtgtcga aggcggtggt ctaccgcatt ctccagtcac
    17641 tggtctcccg cgagatgctc ggcaccgatc ccggcgtggc gggctaccga ctcggcccgg
    17701 ccgcggtggc gctcggcgcg agcgcgctgc gccggttcga cctccgcgtc gcggccgcgc
    17761 cggtgctgcg caggctgcgc gaggaaaccg gcgagaccac cacgctctcc ggcctgctcg
    17821 gcgaccagcg cgtctacctc gagcagttcg agagcgagcg cgagatcaag atgaccgtcg
    17881 aactcggcaa gcggttcccg ctgcacgccg ggtcctcggg caaggtgatc ctggcgaacc
    17941 tgcccgccga ccgccgcgag gcgctgctcg ccgccccgca cgacgcgctg accgagcgca
    18001 ccatagtgga cgacgccgag ctgcgcgccg aactggaccg ggtggccgag gacggcgtcg
    18061 ccgtgtcgct cggtgaacgc caggccggtg ccggttcggt ggccgcgccg gtgttcgggc
    18121 cgaacggcga ggtccagggc gcgatcagcg tctgcggccc cgagtaccgg ttcaccccgg
    18181 acctcgtcga gcgctaccgc gagctggtgc gcgtggcggc cgacgagatc acccgcgccc
    18241 cgctcgccgc ccactgatca gcggccccgc cgctggtacc gcccgaccgg ctcgccggtc
    18301 accttgccgt cggtgtagac gtggtggccg cgcacgaagg tgtcggtcac cttcgcggtc
    18361 atcgggaagc cctcgaacgg cgtgtactcc tgggtggatt cggagtcggc cgcgcgcacg
    18421 gtccacgaca cgtccgggtc gaccagcgcg aagtcggcgt cgtagccctc ggcgatggtt
    18481 cccttgcgca gcaggccgta gcgccgcgcc gggttccacg acgtgagccg cgcgatgtgc
    18541 tggagcgaaa gaccgcgctt gacgccctcg ccgaccagtc cgggcagcag gtactccgcg
    18601 ccaccgaagc cggacttcgc caggaacacg tcgtcccggt cctcgccgaa cttcagctcg
    18661 tcgcggcagc aggcgtggtc gctgaccacc cagtcgacct cgccggccag cacgtgaccc
    18721 cacagcgcct cgacgtcctc gcgctcgcgc agcggcggat tgaccttgcc gccgatgccg
    18781 ctcgcggtgt ccacgtcggc cagcaggtgc ccgaccgtca cctcacgccg gaaatccacc
    18841 tgcggaaagg tcttcgccat gcgcagcgcg gcgtcgagcg ccttctccga ggacaggtgc
    18901 agcaggttga tgttcggcag tccggtctcg tgcgcgaggt aggaggcgat ggtcaccgcg
    18961 agcccttccg aatgcggcgg ccgtgaccgg ctgtacgcgc gcagtccgga aaccgaggtg
    19021 tcctgctcga ccagcttcgt gtacgccgtc atgatctcgg cggtttcgca gtgcagcgac
    19081 agcgaaaggt ggtccgcgta gtcggtcagc tgctcgcgcg cccgctggat gccgcgcatg
    19141 acgaactcga agtgcgccag gtcgtagcgc tcctccggcg ggatcatcag gaagtcgctc
    19201 tggctgctcg accgcccgtg caggccgtgg ctgccgtaga acatgaagat cttgaacgag
    19261 gtgaccccgt gttcctcgac caggtacggg atctcgtcga tgtgctgcgc catcatcggc
    19321 gcgaggtgga aggcgtagtc cacataggcg ttgccgtccg cggcggcgag cacctcgggg
    19381 aagaactcgc ggtagctgcc gcctttgttg aggtagtact gcccggtgcg catgtaggtc
    19441 agcgcggtgg tgaccccgcc ctgcgcgctc gcgcggctct cggtccgggt gtcggtgccc
    19501 agttcgttgt agatgcccca gtgctggtgg gcgtccacca caccgggaaa ggcgagcaga
    19561 ccgcggccgt cgaccacggt ggcggcgtcc gcggggtcca ggccgggcgc gacgcgcgtg
    19621 atcgtgccgt cattgaccgc gatgtcgagc agttccggca ccccgtcggc gtcggcggtg
    19681 tcttcggggc gcaccacgcg aacgttgcgg accagcagtt ccgttgtagc cacttctgtt
    19741 cactccttag cgatagcgtt cgcggccagg taggcgaggc cgaaggcggg cagcaggccg
    19801 ttgcccggca ggtagccgtc ggcgccgtgg ccggagatcc cggccgccgc gccaccggcc
    19861 gcgtacaacc cggggatcgg ccggtcggcg gcgtcgacca cggcggcgtt ctcgttgacc
    19921 agcagcccgc cctgggtgtg gaacaacgcg ggcaccacac gaaccgcggc gtaacgcggc
    19981 gcgagcgggc gttcccagtt ggtgcggccg aactcgtcgg cgcgctcacc tcgcgcgatc
    20041 gcggccgcgg taccgagttc ggcggcgagg gcttcctcgg gcaggccggt gacccgcgcc
    20101 agcgacggga tgtcgtcggc gaagtgcacc gcaccggcgg caaccgtgtc gcggaagtcc
    20161 tggaacggct ggcactgctc gaagatcacc tcgtcgagca cgatccagcc ggtgccgccg
    20221 gggcgcgcgg ccagttcggc ggcgtactcc gagtagccgc gtgtctcgtc cccgaaccgg
    20281 cgcccaccga ggtcgaccag gatgccgccg tggatgatcg tggcccagcc gaccagcgtg
    20341 cccgcgttgg ccgcgaccgc accgtggccc tggtacgcgt ccaggaaacc cgttgcggcg
    20401 ccgagctttt ccccgatgcg caacgcgtcg ccgagtgact ggtcactgcc ctggtacagc
    20461 gcgtccgcga tctccggcag gtgccgtcgc acgagttcgc cgtcggcgcc gtaaccgttg
    20521 gtcgccagca acaccgcgcg cgtcgggatc tcctcttccg cgccgctcgg gtcgcggacc
    20581 accacggcac gaacagcacc gtccacaccg gtcagaacgt cgaccagttt cgcgggcacg
    20641 agcagatcga tgccggggtg ctcggtgacc agccgggcca ggtggtcgac gacgccggag
    20701 ccgtgcctgc cggggatcga gtggcagcgc gggaccgagt ggccagggta gttgaagtcg
    20761 gtgaccagcg agagcggcag ccgcagcgaa tcggccagcc actccaccag cggcgcgctg
    20821 acctcggcca gcgtgcgcgt caaccggggt tcggcctgac cgtgggtctt cgccatgatg
    20881 tcggcggcga agcccgccgg ggaatcgccg acccccgact cccgctgcca gcgcgaaccg
    20941 gcgccgggga acatcgcggt ggacatcgag gtgttgttgc cccgccggaa gtgttcgctc
    21001 gcttcgacca cgagcacgct cagcccgagt tcggcggccc gcagcgcccc ggcgagcccg
    21061 ccgcccgcac cggccacgac cagatcggga ccctcgctca cgcgcactcc ccttccgcca
    21121 tcagcacggt cagcgccagc gcggtcgggt cgaccacccg cgcgggcagg tcggccggga
    21181 ccacgtccac tgccgagcag ccgttgagca ccgctgtcgc accctgatcg gcgaggtcgc
    21241 gcaccgcctc gccgagtgcg gcgttccacg cggcggtgtc ggcgatcgcc tcgaacggca
    21301 ggtcgagcac ccgcaccccg accaggttcg aggtgaggcc gtaggcggcc aggcgccagc
    21361 gcagttccgc gccgatggcc tggttccgca ccaccgcgcc gaaccgctca cccttggccg
    21421 ccaggtgtga cgcactcagc ttgagcaggc cgtgcaccgg gcgcgggccg atcgccacgc
    21481 ggtcgggcac ggccgggtcg agcacgcagt cgggaaaggc cacgtcccag tctccgtccg
    21541 cggcggccag cgcggcggca acggcgcgct cggagtcgcg gaccgacccg tccgtgtcca
    21601 atgcggacgg tgcttccggg ccgacgtcac gcagttcgat ccgcagaccg ggcggggcga
    21661 ggcggtcgta acgggactgg cgacggccga tctcctcggg cgggagatgg atcggggtga
    21721 tcgcgagggc acgcatcagc tcggctcctt tccgtcgagt tcgcgcaggg cggcgccggt
    21781 ggcgggcagc cggggcaggt cacggcagaa ggcgaccgcg ccgtccggca accacggacc
    21841 gagcagggcg atcacttcgg cttcgcccag cgggtggtgg tcggcgtcgc cgatcgggtt
    21901 gggcacctcg gcggtgcgcg tgctgccgtc cgcgtaggtg acggtgaccc gggccgcgcg
    21961 ttcgccgggc aggcgggcgg tgaggtcggc cgcttcggcg agccgcaccc gtttcgccag
    22021 gtcgcggacg gccgggtcgt ccagcggggc ggccggcccg accgctccgg tgagcgcggc
    22081 ggtggcgacg gcgaacgggg tggagaacat cgccgagagc cggttgtccc agtccacacc
    22141 ggacagtccg gcaccgagcg cgtgcgtttc gaccagcacg ctctcgatct ccggaccgcg
    22201 cagcgtgagc atcgcgtcga cggcgggatg ggtgaacgag caggccgcgt gccgcttgaa
    22261 gtagccgagc gtgatgtccc agcgcgtgcc gagttcggcg gtcagctcgt cggcgtccag
    22321 tgagcccagc agctcgccca gcgacaacgc cgccgtgccg gtgttcctgg cgattccggc
    22381 ggcagccatg cgcgcggcca ccagaccgga cacattggac gcacccagcc aggcgtcgcg
    22441 caccggattt cccgtggtgg ccgaagcgaa gtgccctgcg atgggcatac cggcggcggt
    22501 gtcgatcgcg gcggcggtgg cgtccgcgtc caatccgagc aggcgagcgc agcccgccgc
    22561 cgcgccgggc acgccccagt tcccatgggg atgcgtgcca ggacgcagct tcgtcgcccg
    22621 gccgaaccgc gcggccacct cgtacgcggc gagcagggcg gcggccaggt cggcgccgct
    22681 gctgtcgagt tcggcggcga gcgcgagcac ggcgggaaag ccgtgcgcgg ccggatgtcc
    22741 cttggcgtac ttgttgccct cgtccagttc ccgcgacacc agtgccatcg cgccgagcca
    22801 ggccgcggcg tccaccgaca ccagctcacc ggtgccgatc agcggcgcgg gaccggcggg
    22861 cgggcgccag gccgcgtaca gcgcccggtg ctccggctgg ttcgtgccca gcgccatcac
    22921 cccgagcacg tccagcagga ccaggccgag gcggtcgagc gcgggcgcgg agtccagagt
    22981 ggacagcccg gaaacccagg cgcccagttc gtcgacgtgt tccttgctca caggcccagg
    23041 tacgccttcc gcacgcgggc gtcgtcggcc agctcggcgc cggtgccgga cagcaccgcc
    23101 gaaccgctct ccagtacgta cgcccgatcc gcgatggcca gcgcctgctt ggcgttctgc
    23161 tccaccagca gcaccgagac cccggtgtcg cgaatgcggc ggatcgcctc cagcatggtc
    23221 caggtcagct tcggcgagag cccggtcgac ggctcgtcga gcatcagcag cctcggcccg
    23281 gccatcagcg cacgcgcgat ggcgagcatc tgctgctggc cgccgctgaa cgtctgcgcg
    23341 agctgggtcc cgcgttcggc caggatcggg aacagctcgt gcacctcacg cagcgaggcc
    23401 tcggcttgct cggccgtgcg ggtccacgcg cccatgcgca ggttctcctc gacggtcagc
    23461 gtgccgaaca gcgcgcggtc ctccggcacg tgcaccaggc cgtcgcgcac gagctggtcc
    23521 ggcctgcggc ccgcgatcgg cctgccgtcg aaggtgatcg tgcccgagga cggccgcagc
    23581 tggccgcaga tggaccgcag cgtggtggtc ttgcccgccc cgttcgcgcc gaccagcgcg
    23641 acgatctcgc cctcgccgag gtgcaggtcg atctcgtgca ggatgcgcat gcggccatat
    23701 cccgcgcaca cctggtcaag agtcagcacg ggcgggctcc tccccgagat aggcgtcgat
    23761 cacccgtgga tcgctggtga cctcctccgg cgaaccggtg gccagcacgc gaccctggtc
    23821 cagcaccagc acccggtcgg acaaccgcat caccgcggcc atgatgtgct cgatgaacag
    23881 cagcgtggtg ccgtcctgct cacgcagctc ggcgagcagg tcgaggaccg gctcccgttc
    23941 cgcgggcacc agcccggcca gcacctcgtc gagcagcagc acccgcgggc gcatggccag
    24001 cgtgcgggcc agttcgaggc gcttgagccc ggcggtgggc agttcggtgg ccagtcggtg
    24061 cgcccacggg cccagcccga cccgctcgac cacggccagc gaatgctcgt acagccgttt
    24121 cgccggcatc cggcggtgct gcgcggcgag gctgacgttc tgcaccacgg tcatgctggc
    24181 gaacgggcgc atcagctgga acgtgcgcac catgccggcg cgcgcgatgc ggtcgggtga
    24241 ggcgccggtg atgtcgcgcc cggccagctc caccgtgccg gtgtccggtt tgagcgcccc
    24301 gcacaccacg ttgaacagcg tggtcttgcc ggcgccgttc ggcccgatga tgccgacgat
    24361 ctcgccctcg tccaccgcga ggtccacatc ggacagtgcg cgcaggccgc ggaaggactt
    24421 gccgacgccc gagatccgca ccaggctcat cgccgccacc tctccttcag cgtgcccacg
    24481 atccccttcg gcagcagtcg cacgatgagg atcaacagga tcgcgtacag caccacgtcc
    24541 agtccgctgc gcccctgcag gaagccgagg aactccggcg gggtgcgcag cagcgtcgcg
    24601 gtcacgtcgg acagcgaacc catgatcacc gagccgacca ccggacccca caccgtgccg
    24661 atgccgccga tcaccaccgg cacgatggcc tggatggaca ccgaggcgcc gaaggccaga
    24721 tccgggttca cgaacaggta gtactgcgtg tagtaggcgc cggccaccgc ggtgatcgcc
    24781 gcggacagcg ccacggtgag cagtttgtgc cgcatcaccg gcgtgccgag cgaggccgcg
    24841 gccagttcgt cgtcgcggat cgcggtgacg tacttgcccg cccgcgagtg caggaacacg
    24901 atgctgaccg ccaccgcgag cccggccagc accagcgcca cccagaagta ggccggtgag
    24961 tcggcggcga actgcagctg ccacagcgat tcgccctgga tcagcgggac ctggaagccg
    25021 accgcgcggt tgacgaagtc gctgctggtg gcgatcagcc gcagcgcctc ggcgaaggcg
    25081 aaggtggcca gcgcgaagta ggcgccctgc aaccggtagc ggaaggagaa gtacccgatc
    25141 accaccgcca ccgcggcggc gacgcccatt
//
