LOCUS       NZ_CP045480            21089 bp    DNA     circular CON 15-AUG-2024
DEFINITION  Amycolatopsis sp. YIM 10 chromosome, complete genome.
ACCESSION   NZ_CP045480
VERSION     NZ_CP045480.1
KEYWORDS    RefSeq.
SOURCE      Amycolatopsis sp. YIM 10
  ORGANISM  Amycolatopsis sp. YIM 10
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1  (bases 1 to 10312959)
  AUTHORS   Ruckert,C., Guerrero-Garzon,J.F., Zehl,M., Rezaei,S., Selivanova,G.,
            Urban,E., Busche,T., Kalinowski,J., Cao,Y.-R., Jiang,Y., Jiang,C.-L.
            and Zotchev,S.B.
  TITLE     Complete genome sequence of Amycolatopsis sp. YIM 10, isolated from
            a rare earth mine
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 10312959)
  AUTHORS   Ruckert,C., Guerrero-Garzon,J.F., Zehl,M., Rezaei,S., Selivanova,G.,
            Urban,E., Busche,T., Kalinowski,J., Cao,Y.-R., Jiang,Y., Jiang,C.-L.
            and Zotchev,S.B.
  TITLE     Direct Submission
  JOURNAL   Submitted (11-OCT-2019) CeBiTec, Uni Bielefeld, Sequenz 1, Bielefeld
            33615, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2.8
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 80.5x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_009429145.1-RS_2024_08_15
            Annotation Date                   :: 08/15/2024 04:03:36
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,775
            CDSs (total)                      :: 9,711
            Genes (coding)                    :: 9,634
            CDSs (with protein)               :: 9,634
            Genes (RNA)                       :: 64
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 49
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 77
            CDSs (without protein)            :: 77
            Pseudo Genes (ambiguous residues) :: 0 of 77
            Pseudo Genes (frameshifted)       :: 22 of 77
            Pseudo Genes (incomplete)         :: 65 of 77
            Pseudo Genes (internal stop)      :: 1 of 77
            Pseudo Genes (multiple problems)  :: 11 of 77
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 18:01:44
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3444346
            Orig. end                         :: 3465435
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP045480.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Annotated using prokka v1.11 from http://www.vicbioinformatics.com.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21089
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="8"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21089
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21089
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11089](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11089)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(253..939)
                     /locus_tag="YIM_RS16810"
                     /old_locus_tag="YIM_16945"
     CDS             complement(253..939)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009154619.1"
                     /locus_tag="YIM_RS16810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YIM_16945"
                     /product="metalloregulator ArsR/SmtB family transcription
                     factor"
                     /protein_id="WP_153031248.1"
                     /transl_table=11
                     /translation="MDDTSRAAQVAAVAALDEPTRRRLYDLVVRRPDPVSRDEAAEAVR
                     LPRTTVAFHLDRLVEDGLLDVVYERRTGRSGPGAGRPAKLYRRSSRQITVSLPDRRYEL
                     AGRLLADAIQEAETTGDSPRTVLDRRAHELGHDLGQATRTDQPSDDAAMRTLERFGFEP
                     RRTGTTIMLGNCPFHSLASHQTELVCGMNLRLLQGLLDGLAATGLTARLAPAAGHCCVR
                     LEPENQ"
     misc_feature    complement(944..958)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.85"
                     /tool="antismash"
     gene            1019..1630
                     /gene="folE"
                     /locus_tag="YIM_RS16815"
                     /old_locus_tag="YIM_16950"
     CDS             1019..1630
                     /EC_number="3.5.4.16"
                     /GO_function="GO:0003934 - GTP cyclohydrolase I activity
                     [Evidence IEA]"
                     /GO_process="GO:0046654 - tetrahydrofolate biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="folE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GTP_cyclohydroI"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013226227.1"
                     /locus_tag="YIM_RS16815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YIM_16950"
                     /product="GTP cyclohydrolase I FolE"
                     /protein_id="WP_153031249.1"
                     /sec_met_domain="GTP_cyclohydroI (E-value: 1.6e-65,
                     bitscore: 219.0, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAPIPAGPQRQLRVVTGRAGVDPEAAQRAVADLLVALGQDPESE
                     HLADTPRRVADAYGEMLTPREFNLTTFPNDEGYDELVLARGIPVQSLCQHHMLPFHGVA
                     HVGYLPGERILGLSKLARVVELYARDLQVQERLTKQVADWLQQHLAPKGVGVVIEAEHM
                     CMSLRGVRATGSSTVTSALHGVLREDARSRQEFFGLAGIR"
     gene            1715..2317
                     /locus_tag="YIM_RS16820"
                     /old_locus_tag="YIM_16955"
     CDS             1715..2317
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020667499.1"
                     /locus_tag="YIM_RS16820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YIM_16955"
                     /product="maleylpyruvate isomerase family
                     mycothiol-dependent enzyme"
                     /protein_id="WP_153031250.1"
                     /transl_table=11
                     /translation="MRNNNDKIHAWVKAERLGLADFLEGLDEHEWQVPSLCDGWTVRDV
                     AAHMTLSTRMSLRLTVKGVLRSRGNVHRMFDVLARDRAAQFTPAELVAQLRETADSRHL
                     TLGASPLDPLVDALVHGQDVARPLGRPRPMPLDAAVEALEFVWNARFYGARKRLPGTRL
                     VAIDREWTGGDGAREIRGTVSDLLLLATGRTERTVNA"
     gene            complement(2319..3029)
                     /gene="aztA"
                     /locus_tag="YIM_RS16825"
                     /old_locus_tag="YIM_16960"
     CDS             complement(2319..3029)
                     /codon_start=1
                     /gene="aztA"
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020635597.1"
                     /locus_tag="YIM_RS16825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YIM_16960"
                     /product="zinc ABC transporter ATP-binding protein AztA"
                     /protein_id="WP_153031251.1"
                     /transl_table=11
                     /translation="MNENVAAVTLGELRAGYGHREVLRGVTAKLPSRRLTAVVGANGAG
                     KSSLLNVIAGVLPATSGSVRVGGAVRPAYVTQHSEVSDALPITVRATVAMGRWAHRGPW
                     RRLTKKDRAVVEECLERLDITSIAHRRLGTLSGGQRQRALVAQGLAQQSGLLLLDEPAA
                     GLDLRARTLIDEALSAARDDGVTVVRVTHDLAVADQADHCLLLRDGGLVAEGPPRSVLT
                     PARVAEAWGVPVPR"
     misc_feature    complement(2995..3008)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.92"
                     /tool="antismash"
     misc_feature    complement(3043..3057)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 19.08"
                     /tool="antismash"
     misc_feature    3044..3057
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 14.95"
                     /tool="antismash"
     misc_feature    complement(3044..3059)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 23.56"
                     /tool="antismash"
     misc_feature    3047..3062
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: medium, score: 23.97"
                     /tool="antismash"
     misc_feature    complement(3049..3062)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 15.71"
                     /tool="antismash"
     misc_feature    3049..3063
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 21.0"
                     /tool="antismash"
     misc_feature    3050..3063
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 15.85"
                     /tool="antismash"
     misc_feature    complement(3050..3065)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 19.86"
                     /tool="antismash"
     gene            3078..3923
                     /gene="aztB"
                     /locus_tag="YIM_RS16830"
                     /old_locus_tag="YIM_16965"
     CDS             3078..3923
                     /codon_start=1
                     /gene="aztB"
                     /gene_functions="other (smcogs) SMCOG1245: ABC transporter
                     protein, integral membrane"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020635596.1"
                     /locus_tag="YIM_RS16830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YIM_16965"
                     /product="zinc ABC transporter permease AztB"
                     /protein_id="WP_153031252.1"
                     /transl_table=11
                     /translation="MDWLLIPFEVSFVQRALLAGVLVSVVCALVGTWVVLRGMAFIGDA
                     MSHGMLPGVAIASLIGVNPLLGAALSAGVMALGVTALGRSRRLSQDTTIGLLFVGMLAA
                     GVIIVSHSQSFAVDLTGFLFGDVLAVGPGDLNLLAITLVLVAVVSLLGFRSFAALTFDA
                     RKAHTLGLRPGWANAVLLALVTLTIVASFRVVGTLLVFGLLIAPAAAATFWARRIATIM
                     LFAALLGVLATVAGLIVSWHWGTAAGASIAATSVLLFFVSALLSVARRRFLDPTTEIER
                     "
     gene            3920..5143
                     /locus_tag="YIM_RS16835"
                     /old_locus_tag="YIM_16970"
     CDS             3920..5143
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016334381.1"
                     /locus_tag="YIM_RS16835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YIM_16970"
                     /product="hypothetical protein"
                     /protein_id="WP_153031253.1"
                     /transl_table=11
                     /translation="MKLRTRLGLLAIVAVLPAACATEPDQGGPGQAGPGNAGNGQAASA
                     AEAPHGYVEGAEETAEAQSRLVVADAETGAVQVVDLITEQVHPAGRVDGVRGITGDGRF
                     AYLEGRDQAVHLVDSGSWMVDHGDHVHYYRAAVRELGVVPGKQALGAYSDPAVTAVSYP
                     DGTAILFDRAKLDKGEIAELGRITRPPHESSAVPYGEHVLASDGAQGVRVHDRQGKPVA
                     DIEPSCPDLRGQAVTRRGVVFGCADGALLVTEKDKAFAGEKIPYPSEVGEQERATRFSH
                     RPGSTTLAAPAGDNAVWSLDVSRRAWTRVETGPVAAVNAVGEGAPLLVLTRDGVLRAFD
                     SATGEERAQSPLMPDATGAAIQVDTTRAYVNNPASGEVYEIDYNDNLRRARTITVAGKA
                     SHLVETGR"
     gene            5140..6033
                     /gene="aztC"
                     /locus_tag="YIM_RS16840"
                     /old_locus_tag="YIM_16975"
     CDS             5140..6033
                     /GO_component="GO:0043190 - ATP-binding cassette (ABC)
                     transporter complex [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /codon_start=1
                     /gene="aztC"
                     /gene_functions="transport (smcogs) SMCOG1252: cation ABC
                     transporter, periplasmic"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016334380.1"
                     /locus_tag="YIM_RS16840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YIM_16975"
                     /product="zinc ABC transporter substrate-binding protein
                     AztC"
                     /protein_id="WP_153031254.1"
                     /transl_table=11
                     /translation="MKRLLLVLVALLAATGCTAAGESRSSVVVTTNILGDITRAIVGEQ
                     APVTVLMKPNADPHSFGISAQQAAETERAGLIVYNGLGLEEGMLRNVQAAQESGVPVLP
                     VGERVNPIGYAGGDALDPHFWTDPGRVRDAVTVIAEQVIAQVDGVDATVVRANADRYRG
                     EIDALEATMTERFAQIPAERRKLVTNHHVFGYLAQRFGFEVIGAVVPGGTTLASPSASD
                     LKSLADAVRAAGVPAIFADSSQPDRLARVLAEQAGLHVAVTPLFSESLSEPGQGAATYL
                     EMMRANTEAIATSLNP"
     gene            6048..7208
                     /gene="aztD"
                     /locus_tag="YIM_RS16845"
                     /old_locus_tag="YIM_16980"
     CDS             6048..7208
                     /codon_start=1
                     /gene="aztD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007032704.1"
                     /locus_tag="YIM_RS16845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YIM_16980"
                     /product="zinc metallochaperone AztD"
                     /protein_id="WP_153031255.1"
                     /transl_table=11
                     /translation="MTKTLYTALTAVGVLALTACGTEPAARQDNAAAPASTTVAEPVAV
                     TYDGGIYLLDGKTLQVAKDIPLEGFNRLNPAGDDRHLMVSTSTGFRVLDAAGAVLTDNE
                     VKAPKPGHVVRHAGKTVLFADGTGEVTVFDPKTLGTGPLPAPQYKTPEPHHGVAVELAN
                     GELITTLGNEDERPGIAVLDKDREEIARNDQCPGVHGEAAAKGEAVVIGCETGALIYRN
                     GTITKVASPDPYGRIGNQAGSDVSPITLGDYKVDEAAELERPTRISLIDTENATLRHVD
                     LGTSYTFRSLARGPQGEALVLGTDGQIHVIDPVAGTVTRKIAVTGSWQEPLEWQQPRPA
                     IFVRGGTAYVTDPGKKEIHAVDLATGTKTATGALSGVPNEVSGVQG"
     gene            complement(7189..7860)
                     /locus_tag="YIM_RS16850"
                     /old_locus_tag="YIM_16985"
     CDS             complement(7189..7860)
                     /GO_function="GO:0070403 - NAD+ binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014325.4"
                     /locus_tag="YIM_RS16850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YIM_16985"
                     /product="NAD(P)-binding protein"
                     /protein_id="WP_194240176.1"
                     /transl_table=11
                     /translation="MTGHTLIIGFGAIGASAARLLLSSGVPAAQLVTIDHRRDALTEAA
                     NLGVRTVFGDAADRAALRQTGITEARYVIVAVQPDATAVFITMVARDLCGPDAVVVTAV
                     TDRKHVGFLRGADQVVISSDTAGAALAGGALGQRIAPVHQGGSGWLVHSRPVQSSEIGL
                     FPPECDSGAVGVLRGGVRHLGTEAASLRLAAGDRLMIVRRGVVPGSPPDPGTTATTPVP
                     R"
     misc_feature    complement(7830..7844)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.18"
                     /tool="antismash"
     gene            8020..9999
                     /locus_tag="YIM_RS16855"
                     /old_locus_tag="YIM_16990"
     CDS             8020..9999
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016333627.1"
                     /locus_tag="YIM_RS16855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YIM_16990"
                     /product="amino acid transporter"
                     /protein_id="WP_153031257.1"
                     /transl_table=11
                     /translation="MSEGTELAIPASVDSPVRPKPPASGFSRWLLRDQVHPAGPAAGES
                     HAKPHAWWKVMCLTGVDYFSTLSYLPGIAALAAGALSPLATVLIVALTLLGMLPMYRRV
                     AKESPHGQGSVAMLENLLPFWRGKLFVLVLLGFVATSWIITITLSSADATVHALENPLV
                     PGFLHGHEVAVTVVLLLVLGGVFLLGFSEAVSVAIPLVAVFLLLNAVVVGAGIVELIAE
                     PAALSRWVDALTAGGTGVGDILGPAVIAFPLLVLGLSGFETGVSMMPLVAADGRTGEER
                     LAARIRNTRKLLTTAALIMSVYLLATSLITVTLIPPAEFAAGGQANGRALAFLGHELLG
                     GFFGTAYDLSSILILWFAGASAMAGLINIVPRYLPAYGMAPEWGRAVRPVVLVYTLISV
                     LITIAFGADVNAQAGAYATGILAMMVSGAVAVTISSARARRTKAAIAFTVLTLVLLYAL
                     VENIIEKPDGILISGAFIGGIIVVSLISRVSRTTELRAERLEFDETARKFITDSLDHDG
                     ALNVIANKRQAGDHAEYAEKELAQRELNPVPGAADVLFLEIDVVDPSDFSDVLRVRGVE
                     VDGFRILRAESPAVPNALAAILLSLRDHTGVRPHCHFEWSEGSPLGHLLRYLILGQGDT
                     PPVVREILRTAERDPEQRPRIHVG"
     gene            complement(10001..11089)
                     /locus_tag="YIM_RS16860"
                     /old_locus_tag="YIM_16995"
     CDS             complement(10001..11089)
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /GO_function="GO:0010333 - terpene synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0042214 - terpene metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007032722.1"
                     /locus_tag="YIM_RS16860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YIM_16995"
                     /product="family 2 encapsulin nanocompartment cargo protein
                     terpene cyclase"
                     /protein_id="WP_153031258.1"
                     /sec_met_domain="T1TS (E-value: 1.5e-53, bitscore: 181.9,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEAGALAAVLSGPSGLGTSAARIAAQSLPEPAPEPGYAEMSWGD
                     GKASPLYCPAVRRVNEPLAEEVDRRLVTWAADCGFTGAGLDQIAKAGFGKLVMLAHPDS
                     DDPDHLLIAAQLNAAWWAADDYYADDSELGAAPTELPPRLALVMAAMDPVAPAGEFTTE
                     LDEALRGDPILVGLNSAIGHLSRHGSAVQVQRVCYSTFAMFVSWDAYAAWRYTGAYPPA
                     WEYLAARQHDSFYTSMTLIDAVGGYELPAHLYYEPRVRKALMQAGTACVLVNDLFSVEK
                     DAADEHPVCNMVLQIAADRNCSIEEATEATVELHNSIVRDFQEGHRKLRAVPSPELHRF
                     LDGVRDWMAGGFEWHATNPRYR"
     gene            complement(11104..11955)
                     /locus_tag="YIM_RS16865"
                     /old_locus_tag="YIM_17000"
     CDS             complement(11104..11955)
                     /EC_number="2.1.1.255"
                     /GO_function="GO:0000287 - magnesium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: oMT (84-243). E-value: 3.6e-17. Score:
                     53.5. Matches aSDomain: nrpspksdomains_YIM_RS16865_oMT.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004560971.1"
                     /locus_tag="YIM_RS16865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YIM_17000"
                     /product="geranyl diphosphate 2-C-methyltransferase"
                     /protein_id="WP_153031259.1"
                     /transl_table=11
                     /translation="MTSLDRPVLRTAYQRSVADYWDKEKDPVNLRLGEIDGLFHHHYGI
                     GDFDPAVLEAPGETRDDAIIAEMHRLETAQADVLLDHLGPISPGDRLLDAGCGRGGTSV
                     MAHQRFGCRVDGVSISRQQVEFANAQAARLGVDGHVTYHERNMLDTGFETGAFAGIWNN
                     ESTMYVDLTELFAEHARQLAPGGRYVTITGCYNDVTGGRSRAVSQIDQHYICNIHARGD
                     YFKALAANGFVPINVVDLTAATIPYWELRARSSVATGIEDPFLTAYREGSFHYLLIAAD
                     RV"
     aSDomain        complement(11227..11703)
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_YIM_RS16865_oMT.1"
                     /domain_subtypes="oMT"
                     /evalue="3.60E-17"
                     /label="YIM_RS16865_oMT.1"
                     /locus_tag="YIM_RS16865"
                     /protein_end="243"
                     /protein_start="84"
                     /score="53.5"
                     /tool="antismash"
                     /translation="PISPGDRLLDAGCGRGGTSVMAHQRFGCRVDGVSISRQQVEFANA
                     QAARLGVDGHVTYHERNMLDTGFETGAFAGIWNNESTMYVDLTELFAEHARQLAPGGRY
                     VTITGCYNDVTGGRSRAVSQIDQHYICNIHARGDYFKALAANGFVPINVVDLTAA"
     gene            12306..12878
                     /locus_tag="YIM_RS16870"
                     /old_locus_tag="YIM_17005"
     CDS             12306..12878
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF028235.4"
                     /locus_tag="YIM_RS16870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YIM_17005"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_228004786.1"
                     /transl_table=11
                     /translation="MIKGEQTRAKLIAAARTLLEEKGYHGTALNEVLALAGAPRGSLYH
                     HFPGGKDELVGTALTAAGQEVDELLAGVAGTAADARALVPGVLAALADRMQAADYAKGC
                     PVATVALEVASSESDLQARCGDIYAGWEGALVEVLRAEGRDSAEAEELAATVLALIEGA
                     LVLARARRSRVPIEQVTRRIGVLLEQG"
     gene            12884..14479
                     /locus_tag="YIM_RS16875"
                     /old_locus_tag="YIM_17010"
     CDS             12884..14479
                     /NRPS_PKS="Domain: NAD_binding_4 (6-231). E-value: 6.6e-30.
                     Score: 95.9. Matches aSDomain:
                     nrpspksdomains_YIM_RS16875_NAD_binding_4.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_binding_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013530.4"
                     /locus_tag="YIM_RS16875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YIM_17010"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_153031260.1"
                     /sec_met_domain="NAD_binding_4 (E-value: 1.1e-27, bitscore:
                     95.9, seeds: 102, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDRVVFGAAGFLGRWTVLHLLGRGRAVAAVVRRPGELRDWLVAHG
                     AAVDRLTLLTGDLTKGPGLGLSPADDERLAGVRDVFNSAAVYRFGLRREEATPVNVDGA
                     VNVLRWAKTRPNLRRLVHVSGYRVGLDPRPRYPIPEAELAALYREKGAYEGSKFEADAA
                     VRVLAGELGIPLTVVNPSTVIGHSVTGEAGQYLGLAALVRDLWTGRLPVLPGSARTFVP
                     VVTVDHFAEFTAALPEHDAIGRHWVLDENTPELPALVRLLAGHLGVRAPKLRVPAGAIR
                     RLPTALTGADPETLTFLTGDRYDTASADRVARAAGLRHPPVETALRRWADRLVADGFGD
                     TPAALPGGFQGVAGSRAYVAGARVTPDFVFLQGVEPSAEPWREVIAELGPAPVLVADLP
                     GLGRSAPSDVTPRDWLADLLAPVETRPVLVVHPAAAGPAIRCAAAHPGRVAAVVVVPPE
                     FVPAGSAAGPRRPGAARRTARWLRAANEPGEREAVRVLGESVPVRWMTGDASPAAVARE
                     CHLGAGVRRGGDPA"
     aSDomain        12902..13576
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_YIM_RS16875_NAD_binding_4.1"
                     /evalue="6.60E-30"
                     /label="YIM_RS16875_NAD_binding_4.1"
                     /locus_tag="YIM_RS16875"
                     /protein_end="231"
                     /protein_start="6"
                     /score="95.9"
                     /tool="antismash"
                     /translation="GAAGFLGRWTVLHLLGRGRAVAAVVRRPGELRDWLVAHGAAVDRL
                     TLLTGDLTKGPGLGLSPADDERLAGVRDVFNSAAVYRFGLRREEATPVNVDGAVNVLRW
                     AKTRPNLRRLVHVSGYRVGLDPRPRYPIPEAELAALYREKGAYEGSKFEADAAVRVLAG
                     ELGIPLTVVNPSTVIGHSVTGEAGQYLGLAALVRDLWTGRLPVLPGSARTFVPVVTVDH
                     FAE"
     gene            complement(14487..15209)
                     /locus_tag="YIM_RS16880"
                     /old_locus_tag="YIM_17015"
     CDS             complement(14487..15209)
                     /EC_number="3.4.21.-"
                     /GO_function="GO:0004252 - serine-type endopeptidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020634027.1"
                     /locus_tag="YIM_RS16880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YIM_17015"
                     /product="trypsin-like serine protease"
                     /protein_id="WP_153031261.1"
                     /transl_table=11
                     /translation="MRLRSLAVLIGSALMALLGLAVPATSAAEETGGVQPFIIGGQYAT
                     SGPWAARLFANGRQTCTSTIIAPQYILTAKHCVASSGTYTFRIGSLDQQSGGTMATGDT
                     ITRYPGSADLAIVRLTTAVNATYSPLGTTSDVSTGQTVQVYGWGATSRCGSEINCQSRY
                     LKYANVRVNSVNCSDYYGGISVCANRIDGITAGGDSGGPMFASGRQVGVASTSDRSNNT
                     AYTNITRYRSWIQQVAGV"
     misc_feature    complement(15313..15328)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 22.12"
                     /tool="antismash"
     gene            complement(15407..15547)
                     /locus_tag="YIM_RS16885"
                     /old_locus_tag="YIM_17020"
     CDS             complement(15407..15547)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="YIM_RS16885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="YIM_17020"
                     /product="hypothetical protein"
                     /protein_id="WP_153031262.1"
                     /transl_table=11
                     /translation="MTVPTESPEATPMRRSTADTLTLRAVLLAALCGSLVVAAYTLFTR
                     L"
     misc_feature    complement(15764..15778)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.4"
                     /tool="antismash"
     misc_feature    complement(15772..15785)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 16.75"
                     /tool="antismash"
     gene            15792..17339
                     /locus_tag="YIM_RS49160"
                     /old_locus_tag="YIM_17025"
     CDS             15792..17339
                     /EC_number="2.7.11.1"
                     /GO_function="GO:0004674 - protein serine/threonine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012298.4"
                     /locus_tag="YIM_RS49160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YIM_17025"
                     /product="serine/threonine-protein kinase"
                     /protein_id="WP_228004787.1"
                     /sec_met_domain="Pkinase (E-value: 6.8e-40, bitscore:
                     136.2, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEGRFTPLAAEDPREVGGYRLRARLGVGGMGRVYLAFSPGGRALA
                     IKVVRAEHAEDEEFRRRFEQEIAAARRVQGMYTAEVVDADATAAVPWLATAYVPGPSLR
                     QAVAEHGSLPSETVFRLVAGVAEGLVAVHACDIVHRDLTPANVLLAEDGPRVIDFGIAH
                     AAAATSLTRSGISIGTPAFMAPEQVRGRPATAATDVFALGHLAVFAATGHPAFGEGNRD
                     AMFYRILSEEPELTGCPEDLQPIVRRCLAKEPDDRPSLDEVLAEVAGHAEPRLPGDWLP
                     DGVTQAFKRYDTALYTVHETKKKPGQEKKPKQEKKPQGDKKPQQEKKPQQGKSQRDNKR
                     ASPVGGVIAVAALLAIPVIGAIGPEKVLNAADEFFSANSTSTTTKRATGTTTTKRTAAT
                     TTRKASTRTTTKKTTTTTTRGAWEGCSEAAEAFETLEETRVSDDRKVNAAAYRKLANSL
                     DSIADTAGSAIDSTLEKLANGYQDVADYLASGNTEAFSSLAADLNDDAANLLDRCRG"
     gene            complement(17344..17871)
                     /locus_tag="YIM_RS16895"
                     /old_locus_tag="YIM_17030"
     CDS             complement(17344..17871)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF026899.4"
                     /locus_tag="YIM_RS16895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YIM_17030"
                     /product="Imm15 family immunity protein"
                     /protein_id="WP_194240177.1"
                     /transl_table=11
                     /translation="MTAEIDRFREDFERLLAEGDLLDFDALMTYDGYFDELPLYATYAD
                     ISFLSELPLMERNGVLVRAAVEHLGRIYEHAERFYAGREFDFFCAVTVTGWEFLPEGDP
                     LTPRFWRANPSRGVFEHLRLRPPGSEGSTIVAYLLGRDSGFLLNDDIVNGRLERVFVQL
                     PDHPLPPGTIAD"
     misc_feature    18171..18185
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.13"
                     /tool="antismash"
     misc_feature    complement(18677..18690)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.92"
                     /tool="antismash"
     misc_feature    complement(18887..18902)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.19"
                     /tool="antismash"
     misc_feature    complement(19013..19026)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.39"
                     /tool="antismash"
     misc_feature    complement(19334..19349)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 22.97"
                     /tool="antismash"
     misc_feature    complement(19943..19957)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.92"
                     /tool="antismash"
     misc_feature    20361..20375
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.83"
                     /tool="antismash"
     misc_feature    20468..20483
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.38"
                     /tool="antismash"
     misc_feature    complement(20589..20603)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.18"
                     /tool="antismash"
ORIGIN
        1 cccggaagcg gccggacgcg cacgcgtggc agcggcggcg aacgagtggc aggcaggtgg
       61 gaacgaccat ccaattggag agcacagaag tacaccggtt tctgtgagaa gtccgcagca
      121 agaagaagcg cggcgcacag gcgcgacgcg cgacgaaatc agcgcttggg aggtctcaca
      181 ggtggtacaa cggcacgtcc ttgcccagac gacatggtcc ggccgtacgg taatggcccg
      241 ccgggccgcg ctctactggt tttccggctc gaggcggacg cagcagtgcc cggcggcggg
      301 ggccaggcgg gcggtcagcc cggtggcggc gaggccgtcg agaagtcctt gcagcaggcg
      361 gagattcatg ccgcagacga gttccgtctg gtgcgaggcc aggctgtgga acgggcagtt
      421 gcccagcatg atggtggtgc cggtgcgccg gggttcgaag ccgaaacgtt ccagggtgcg
      481 catcgcggcg tcgtcggagg gctggtcggt gcgggtggcc tggccgaggt cgtggcccag
      541 ttcgtgggcg cgccggtcca gcacggtgcg tggggagtcc ccggtggttt cggcttcctg
      601 gatggcgtcg gccagcaggc ggccggccag ttcgtagcgg cggtccggca gggagaccgt
      661 gatctgccgg gacgagcggc ggtacagctt ggccgggcgg cccgcgccgg gcccgctgcg
      721 gccggtgcgg cgttcgtaga cgacgtcgag caggccgtct tcgacgagcc ggtcgaggtg
      781 gaaggcgacg gtggtgcgcg gcaaccgcac cgcctcggcc gcctcgtccc ggctgaccgg
      841 gtcgggccgg cgcacgacga ggtcgtacag cctgcggcgg gtcggctcgt cgagtgcggc
      901 gaccgcggcg acctgggcgg cgcgagaggt gtcgtccatc ttctaaaaac gatctccgtt
      961 gactgaattg gcgaggtggt tctaaggtta gcgcgagttg ttgttagaag gaggacctat
     1021 ggccgcgccg atcccggcgg gaccgcagcg tcagctgcgg gtggtgaccg gacgcgccgg
     1081 cgtcgatccg gaggcggcgc agcgcgccgt ggcggatctg ctggtcgcgc tggggcagga
     1141 tccggagtcg gagcacctgg ccgacacgcc gaggcgggtc gccgacgcgt acggcgagat
     1201 gctcaccccg cgcgaattca acctgaccac ctttcccaac gacgagggct acgacgaact
     1261 cgtgctggcc cgcggcatcc cggtgcagtc gctgtgccag caccacatgc tgccgttcca
     1321 cggggtggcg cacgtcggtt acctgcccgg cgagcgcatc ctcgggctgt cgaagctggc
     1381 gcgcgtggtc gagttgtacg cccgcgacct gcaggtgcag gagcgcctga ccaagcaggt
     1441 ggccgactgg cttcaacagc acctcgcgcc caagggggtc ggcgtggtga tcgaggccga
     1501 gcacatgtgc atgtcgctgc gcggggtgcg ggccaccggg tccagcaccg tgacctcggc
     1561 actgcacggt gtgctgcggg aggacgcccg gtcgcggcag gagttcttcg ggctcgccgg
     1621 aatccgctga aagaaatttc cgggtggctg tccttccgcc ggtggcccgt tcgtagtgac
     1681 agcgaacgag cagccgacag caggggagcg caccgtgcgg aacaacaacg acaagatcca
     1741 cgcctgggtc aaggccgagc ggctcgggct cgccgacttc ctcgagggcc tggatgagca
     1801 cgagtggcag gtgccgtccc tctgcgacgg ctggacggtg cgcgatgtcg ccgcgcacat
     1861 gacgctgtcc acgcggatgt ccctgcggct caccgtcaag ggcgtgctgc gttcgcgtgg
     1921 caacgtgcac cggatgttcg acgtgctcgc gcgggaccgc gccgctcagt tcacgcccgc
     1981 ggaactggtg gcgcagctcc gcgagacggc tgactcgcgg cacctcacgc tcggtgccag
     2041 cccgctggac ccgctggtcg acgcgctggt ccacgggcag gacgtcgccc gtccgctggg
     2101 caggccgcgg ccgatgccgc tggacgcggc cgtggaggcg ctcgagttcg tctggaacgc
     2161 gcggttctac ggcgcgcgga agcgcctgcc cggcacccgg ctcgtcgcca tcgaccggga
     2221 atggaccggc ggcgacgggg ccagggagat ccggggcacc gtctcggatc tgctgctgct
     2281 cgccaccggg cggaccgagc ggaccgtgaa cgcctgagtc atcggggcac gggcacgccc
     2341 caggcttcgg ccaccctggc cggagtcagc accgaacggg gcgggccttc ggcgacgagc
     2401 ccgccatccc gcagcagcag gcagtgatcc gcctggtcgg cgacggcgag gtcgtgggtg
     2461 acccgcacga ccgtcacgcc gtcgtcgcgg gcggcgctga gcgcctcgtc gatcagggtc
     2521 cgcgcacgca ggtccagccc ggccgccggt tcgtcgagca gcagcagccc ggactgctgc
     2581 gccaggccct gcgccaccag cgcccgctgc cgctgcccgc ccgagagggt gccgagcctg
     2641 cggtgggcga tcgaggtgat gtccaagcgc tccaggcact cttcgaccac cgctcggtcc
     2701 tttttggtca gtcggcgcca cgggccgcga tgcgcccagc ggcccatggc gaccgtggcg
     2761 cgcaccgtga tcggcagtgc gtcggacacc tcgctgtgct gggtcacgta ggcgggccga
     2821 acggcaccgc cgacgcgcac cgagccggat gtggccggta gcaccccggc gatcacgttg
     2881 agcagggacg acttcccggc tccgttcgcc ccgacgaccg cggtgagccg ccgcgacggc
     2941 agcttcgccg tgaccccgcg cagcacttcc cggtgaccat aacccgcgcg cagttcaccc
     3001 agggtgaccg ccgccacgtt ctcgttcatc tgacaccgcc caagataatg acaatcatta
     3061 ccactatagt gtccggtgtg gactggttgc tcatcccctt cgaggtgtcg ttcgtgcagc
     3121 gtgcgctgct ggccggggtg ctggtgtcgg tggtgtgcgc gctcgtgggc acctgggtgg
     3181 tgctgcgcgg catggccttc atcggcgacg cgatgtcgca cggcatgttg cccggcgtgg
     3241 cgatcgcctc gctgatcggc gtgaacccgc tgctcggggc cgcgctcagc gccggggtga
     3301 tggcactggg cgtcaccgcg ctcggccgct cgcgacggct ttcgcaggac accaccatcg
     3361 gcctgctctt cgtcggcatg ctcgccgccg gcgtgatcat cgtttcgcac tcgcagtcgt
     3421 tcgcggtcga cctcaccggc ttcctcttcg gtgacgtgct cgcggtcggc cccggcgacc
     3481 tgaacctgct cgcgatcacg ctggtgctgg tggccgtggt gtcgctgctg ggtttccgct
     3541 cgttcgccgc gctgaccttc gacgcgagga aggcgcacac gcttggcctg cgcccgggat
     3601 gggcgaacgc ggtgctgctc gcgctggtga cgctgaccat cgtcgcgtcg ttccgggtgg
     3661 tcggcacgct gctggtgttc ggcctgctca tcgcgcccgc cgcggcggcg accttctggg
     3721 cccggcggat cgccacgatc atgctgttcg ccgcgttgct gggggtgctg gccacggtag
     3781 ccgggctgat cgtgtcctgg cactggggca ccgccgccgg ggcgagcatc gcggccacct
     3841 ccgtcctctt gttcttcgtc tccgcgctgc tgtccgtcgc gcggcggcga ttccttgacc
     3901 cgacaacgga gatcgagcga tgaaactcag aacacgcttg gggctgctcg cgatcgtggc
     3961 cgtgctgccc gcggcctgcg ccaccgagcc ggaccaaggc ggtccggggc aagccgggcc
     4021 gggcaacgcc gggaacggcc aagccgcgtc cgccgccgaa gcaccgcacg gttacgtcga
     4081 aggcgccgaa gaaaccgccg aggcgcagtc gcggctggtg gtggccgacg ccgaaacggg
     4141 cgccgtgcag gtggtggacc tgatcaccga acaggtccac ccggcgggcc gcgtcgacgg
     4201 ggtgcgggga atcaccggcg acgggaggtt cgcctacctc gaaggccggg accaagcggt
     4261 tcacctggtc gacagcggat cgtggatggt cgaccacggc gaccacgtgc actactaccg
     4321 cgccgcggtc cgcgaactcg gggtggtgcc ggggaagcag gcgctcgggg cgtacagcga
     4381 tcccgcggtg accgcggtgt cctatccgga cggtacggcg atcctgttcg accgcgcgaa
     4441 gctagacaag ggcgaaatcg cggaactggg caggatcacc cgcccgccgc atgagagcag
     4501 cgcggtgccc tacggcgaac acgtcctggc ttccgatggc gcacaagggg tgcgcgtcca
     4561 cgaccggcag ggcaagccgg tggcggacat cgagccgtcg tgcccggatc tccggggaca
     4621 ggcggtgacc cggcgcgggg tggtcttcgg ctgcgcggac ggcgcgttgc tggtcaccga
     4681 gaaggacaag gcgttcgcgg gggagaagat cccgtatccg agcgaggtcg gcgaacagga
     4741 gcgggcgacc cggttcagcc atcggccggg cagcaccacg ctcgcggcac cggccgggga
     4801 caacgccgtg tggtcgctgg acgtcagccg ccgggcgtgg acgcgggtcg aaaccgggcc
     4861 ggtcgccgcg gtgaacgcgg tgggggaggg cgcgccgctg ctggtgctga cccgcgacgg
     4921 ggtgctgcgc gcgttcgaca gcgccaccgg tgaggagcgg gcgcagtccc cgttgatgcc
     4981 ggacgcgacc ggggccgcca tccaggtcga caccacccgc gcctacgtca acaacccggc
     5041 ttcgggagag gtctacgaga tcgactacaa cgacaacctg cgccgcgcca ggacgatcac
     5101 cgtcgcgggc aaggccagcc acctggtgga gaccgggcgg tgaagcggct gctgctggtc
     5161 ctcgtcgcgc tgctggccgc caccggctgc accgcggcgg gcgaaagccg gtcctcggtg
     5221 gtggtcacca cgaacatcct cggcgacatc acccgcgcca tcgtgggtga gcaggccccg
     5281 gtgaccgtgc tgatgaagcc gaacgccgac ccgcactcct tcggcatctc cgcgcaacag
     5341 gccgcggaaa ccgaacgcgc cgggctgatc gtctacaacg gactcggcct cgaagagggc
     5401 atgttgcgga acgtccaggc ggcacaggaa agcggggttc ccgtgctgcc ggtgggggaa
     5461 cgggtgaacc cgatcggtta cgccggcggt gacgcgctcg atccgcactt ctggaccgat
     5521 cccggccggg tacgcgacgc ggtgaccgtg atcgcggagc aggtgatcgc ccaggtggac
     5581 ggcgtggacg cgacggtggt gcgggccaac gccgaccggt accgcggtga gatcgacgcg
     5641 ctcgaagcca cgatgaccga gcggttcgcg cagatcccgg cggagcgccg gaagctcgtc
     5701 accaaccacc acgtcttcgg ttatctcgcg cagcgcttcg gcttcgaggt gatcggcgcg
     5761 gtcgttcccg gtggcaccac gctcgcctcg cccagcgctt cggacctgaa gtcgctggcc
     5821 gacgcggtcc gggccgccgg tgtcccggcg attttcgccg actcctcgca accggaccgg
     5881 ctcgcgcgcg tactggccga acaggccggg ctgcacgtcg ccgtgacgcc gttgttctcc
     5941 gaatcgctga gcgaacccgg acagggcgcg gcgacctacc tggaaatgat gcgcgccaac
     6001 accgaggcga tcgccaccag cttgaacccc tgattgaaag gtgcaagatg accaagacgc
     6061 tgtacacggc gctcaccgcg gtgggcgtgc tcgcgctgac ggcctgcggg accgagccgg
     6121 cggcccggca ggacaacgcc gcggcaccgg ccagtaccac cgtggccgag cccgtcgccg
     6181 tcacctacga cggcgggatc tacctgctcg acgggaaaac cctccaggtg gccaaggaca
     6241 tcccgctcga gggcttcaac cggctcaacc cggccggcga cgacaggcac ctgatggtgt
     6301 ccacctccac cgggttccgc gtgctcgacg ccgccggtgc cgtgctgacc gacaacgagg
     6361 tcaaggcgcc caagccgggc cacgtcgtcc gccacgccgg gaagacggtg ctcttcgccg
     6421 acggcaccgg cgaggtgacc gtgttcgacc cgaagacgct cggcaccggg ccgttgcccg
     6481 cgccgcagta caaaacgccg gaaccgcacc acggggtcgc cgtcgagctg gccaacggcg
     6541 agctgatcac caccctcggc aacgaggacg agcggccggg catcgcggtg ctggacaagg
     6601 accgcgagga aatcgcgcgc aacgaccagt gccccggcgt gcacggtgaa gcggccgcca
     6661 agggcgaggc ggtggtgatc ggctgcgaga ccggcgcgct gatctaccgc aacggcacca
     6721 tcaccaaggt cgccagcccc gacccgtacg gccggatcgg caaccaggcc ggctccgacg
     6781 tctccccgat cacgctcggc gactacaagg tcgacgaggc cgccgagttg gagcgcccca
     6841 cccggatttc cctgatcgac accgaaaacg ccacgctgcg gcacgtcgat ctcggcacca
     6901 gctacacctt ccggtcgctg gcccgcggtc cgcagggcga ggcgctggtg ctcggcaccg
     6961 acggccagat ccacgtgatc gacccggtgg cgggcacggt gacgcgcaag atcgcggtga
     7021 ccggctcctg gcaggaaccg ctggagtggc agcagccgcg cccggcgatc ttcgtccgcg
     7081 gcgggaccgc ctacgtcacc gacccgggca agaaggagat ccacgcggtg gacctcgcca
     7141 cgggcaccaa gaccgcgacc ggcgcgctgt ccggcgtgcc gaacgaggtc agcggggtac
     7201 aggggtagtc gcggtggtgc cggggtccgg cggggatccc ggcaccacac cgcgccgcac
     7261 gatcatcagc cggtcacccg cggcgagccg tagcgaggcg gcttcggtgc ccaggtgccg
     7321 cacgccgccg cgcagcaccc cgaccgcgcc ggaatcgcac tcgggcggga acaggccgat
     7381 ctccgaggac tgcacgggac gcgaatgcac cagccagccg gacccgccct ggtgcacggg
     7441 agcgatgcgc tggcccagcg cgccgccggc cagtgcggcg cccgcggtgt cggaggagat
     7501 gaccacctgg tccgcgccgc ggaggaagcc cacgtgcttc cggtcggtga ccgcggtgac
     7561 caccaccgcg tccggcccgc acaggtcgcg ggcgaccatg gtgatgaaca cggccgtggc
     7621 gtcgggctgc acggccacga tcacgtaccg cgcctcggtg atcccggtct gccgcagggc
     7681 cgcccggtcg gcggcgtcgc cgaacaccgt gcgcacgccc aggttcgcgg cctcggtgag
     7741 ggcgtcgcgg cgatggtcga tggtgacgag ttgagcggcg ggcacgccgc tggagagcag
     7801 cagcctggcc gcggaggcgc cgatcgcgcc gaaaccgatg atcagggtgt ggccggtcaa
     7861 ctggtccccc gcctgcgtcg gcacatggag cgcgagtaga cccggtcggg ggacgcccga
     7921 aaagaccttt ggtggaatct ttacgacttc tttgcgcccg gctcgcggat tcgcggggcg
     7981 atgtgcgtaa acggtttttc gtgcggcatt ctggacccca tgagcgaagg caccgaactg
     8041 gcgattccgg ccagtgtgga cagcccggtg cgcccgaaac cgccggcttc gggcttttcc
     8101 cgctggttgt tgcgcgacca ggtgcacccg gcgggcccgg cggcggggga gtcacacgcg
     8161 aaaccgcacg cctggtggaa ggtgatgtgc ctgaccgggg tggattactt ttccaccttg
     8221 tcctatttgc cgggtatcgc cgcattggcc gccggtgcgc tttcgccgct ggccaccgtg
     8281 ctcatcgtcg cgctgaccct gctgggcatg ctgccgatgt accggcgggt ggccaaggag
     8341 agcccgcacg gccagggctc ggtggcgatg ctggagaacc tgctgccgtt ctggcggggc
     8401 aagctcttcg tgctggtgct gctgggtttt gtcgccacct cgtggatcat caccatcacg
     8461 ctgtcctcgg ccgacgccac cgtgcacgcg ctggagaacc cgctggtgcc cggtttcctg
     8521 cacgggcacg aggtggcggt caccgtggtg ctgctcctgg tgctgggcgg ggttttcctg
     8581 ctcgggttca gcgaagcggt cagcgtggcc attccgctgg tcgcggtgtt cctgctgctg
     8641 aacgcggtgg tggtcggggc gggcatcgtc gaactgatcg ccgagcctgc cgcgctgtcg
     8701 cgctgggtgg acgcgctgac cgccggcggc accggggtcg gcgacatcct cgggcccgcc
     8761 gtcatcgcct tcccgttgct ggtgctcggc ctgtccggct tcgaaaccgg cgtgagcatg
     8821 atgccgctgg tcgccgcgga cggccgtacc ggcgaggaac ggctcgccgc ccgcatccgc
     8881 aacacgcgga agctgctcac caccgccgcc ctgatcatgt cggtctacct gctggcgacc
     8941 agcctgatca cggtgacgct cattccgcca gccgagttcg cggccggggg acaggcgaac
     9001 gggcgggcac tggccttcct cgggcacgaa ctgctcggcg ggttcttcgg caccgcctac
     9061 gacctcagca gcatcctgat cctctggttc gccggtgctt cggcgatggc cgggctgatc
     9121 aacatcgtgc cgcggtacct gcccgcctac ggcatggcgc cggaatgggg ccgcgcggtc
     9181 cggccggtgg tgctggtcta cacgctgatc agcgtgctga tcacgatcgc cttcggggcg
     9241 gacgtcaacg cgcaggccgg tgcctatgcc accggtatcc tggcgatgat ggtctccggc
     9301 gcggtcgcgg tgaccatttc ctcggcgcgg gcgcggcgca ccaaggccgc gatcgcgttc
     9361 accgtgctca ccctggtgct gctctacgcg ctcgtcgaga acatcatcga aaagcccgac
     9421 ggcatcctga tctcgggtgc gttcatcggc ggcatcatcg tggtctcact gatctcgcgt
     9481 gtctctcgca ccaccgaact ccgcgccgag cgcctcgaat tcgacgagac cgccaggaag
     9541 ttcatcaccg actccctcga ccacgacggc gcgctcaacg tgatcgcgaa caagcgccag
     9601 gccggtgacc acgccgaata cgccgaaaag gagctggcgc agcgcgaact caacccggtg
     9661 cccggcgcgg cggacgtgct gttcctggaa atcgacgtgg tcgacccgtc cgacttcagc
     9721 gacgtgctgc gggtgcgcgg cgtggaggtc gacggattcc ggatcctgcg tgccgagagc
     9781 ccggcggtgc cgaacgcgct cgcggcgatc ctgctgagcc tgcgtgacca caccggcgtc
     9841 cggccgcact gtcatttcga gtggagcgag ggcagcccac tcgggcacct gttgcgctac
     9901 ctcattctcg gccagggcga cacgccgccg gtggtccgcg aaatcctgcg gaccgccgaa
     9961 cgcgatccgg agcagcgccc ccgcatccac gtcgggtgag tcagcggtac cgcggattgg
    10021 tcgcgtgcca ttcgaagccg cccgccatcc agtcgcggac gccgtcgagg aagcggtgca
    10081 gttcgggcga tggcacggca cgcagtttcc ggtgcccctc ctggaaatcg cgcacgatcg
    10141 aattgtgcag ttcgacggtg gcctcggtgg cctcctcgat ggagcagttc cggtcggccg
    10201 cgatctgcag caccatgttg cacaccgggt gctcgtcggc ggcgtccttc tccaccgaga
    10261 acaggtcgtt gaccagtacg caggccgtgc ccgcctgcat gagcgccttg cgcacacgcg
    10321 gttcgtagta caggtgcgcc ggcagttcgt aaccgccgac ggcgtcgatc agcgtcatcg
    10381 aggtgtagaa gctgtcgtgc tgccgcgcgg ccaggtactc ccacgcgggc gggtaggcgc
    10441 cggtgtagcg ccaggccgcg taggcgtccc acgacacgaa catcgcgaac gtcgaatagc
    10501 agacgcgctg cacctgcacg gcgctgccgt gccgggacag gtgcccgatg gcggagttca
    10561 gcccgaccag gatggggtca ccgcgcagcg cctcgtccag ttcggtggtg aactcgccgg
    10621 ccggcgcgac cgggtccatc gcggccatca ccagtgcgag ccgcggtggc agttcggtcg
    10681 gcgcggcacc gagttcgctg tcgtcggcgt agtagtcgtc ggccgcccac cacgccgcgt
    10741 tcagctgcgc cgcgatcagc aggtggtcgg gatcgtcgga atcggggtgg gcgagcatga
    10801 ccagcttgcc gaacccggcc ttggcgatct ggtccaggcc cgcgccggtg aacccgcagt
    10861 ccgccgccca ggtcaccagg cgccggtcca cctcctcggc gagcggttcg ttgacccgcc
    10921 gcaccgcggg gcagtagagc ggggacgcct tgccgtcacc ccagctcatc tccgcgtagc
    10981 ccggttcggg cgcgggttcg ggaagggact gcgccgcgat cctggccgcc gaggtgccga
    11041 ggccggaggg cccggacagc acggcggcga gcgctccggc ctcggtcatc gcgcctcccc
    11101 cgctcagacc cggtcggcgg cgatgagcag gtagtggaaa ctgccttcgc gataggcggt
    11161 gaggaacggg tcctctatgc cggtggccac cgacgaccgc gcgcgcagct cccagtacgg
    11221 gatcgtcgcg gcggtcaggt cgaccacgtt gatcggcacg aaaccgttgg ccgccagtgc
    11281 cttgaagtag tcaccgcggg cgtggatgtt gcagatgtag tgctggtcga tctggctgac
    11341 cgcccgcgag cggccgccgg tcacgtcgtt gtagcacccg gtgatcgtca cgtaccggcc
    11401 gccgggggcg agctgacggg cgtgttcggc gaacagttcg gtcaggtcga cgtacatggt
    11461 cgactcgttg ttccagatcc ccgcgaacgc gccggtttcg aagccggtgt ccagcatgtt
    11521 gcgctcgtgg taggtcacgt gcccgtccac gccgagccgc gccgcctggg cgttcgcgaa
    11581 ttccacctgc tgacgggaaa tcgacacgcc gtccacccgg cagccgaatc gctggtgggc
    11641 catcacgctg gtgccgccgc gcccgcagcc cgcgtcgagc agccggtcgc cgggggaaat
    11701 ggggccgagg tggtcgagca gcacatcggc ctgcgcggtt tccaggcggt gcatttcggc
    11761 gatgatggcg tcgtcgcggg tttccccggg cgcttccagc acagcggggt cgaaatcgcc
    11821 gatgccgtag tggtggtgga aaagaccatc gatctcaccc aaacgaaggt tgaccggatc
    11881 cttctccttg tcccagtaat cggcgactga acgctggtag gcggtgcgca gcacgggacg
    11941 gtcgagagaa gtcattccag cggctccttc agaatccagc gcggtgaatc cagcacctct
    12001 agcatgctgg atgtttgttc gaagacgggg cgaatgcggt ccaacgctag acttcgtttc
    12061 ctggtcggga caaggcggct gaacgcggtt cactctcggg tggccggtgg gtgaggcagc
    12121 gttgcctgcc tggcctagtc ggctcgcctg ccggtcggtg cgggaatgct gttacaccga
    12181 cattcggccc catttccctc tcgaacggct caaggtccat tcactgtcag tggtgtcgag
    12241 gtgccgctcg gcgatcgtcg aacccgaggt ggcgaagatt atgtagatcg gtctactctg
    12301 acggcgtgat caagggtgag cagaccaggg cgaagctgat cgccgcggcc aggacgctgc
    12361 tggaggagaa ggggtaccac ggcaccgcgc tcaacgaggt gctcgcgctg gccggtgcgc
    12421 cgagggggtc gctgtaccac cacttccccg gcgggaagga cgagctggtc ggcacggcgc
    12481 tgaccgcggc cggtcaggag gtcgacgagc tgctggccgg tgtcgccgga accgcggccg
    12541 acgcgcgtgc gctcgtgccc ggcgtcctgg ccgcgctggc cgaccggatg caggcggcgg
    12601 actacgcgaa gggctgcccg gtggcgaccg tggcgctgga ggtcgcgtcg tcggaaagtg
    12661 acctgcaggc gcggtgcggt gacatctacg cgggctggga gggcgcgctg gtggaggtgc
    12721 tgcgagccga ggggcgcgac tccgccgagg cggaggagct ggcggcgacc gtgctcgccc
    12781 tgatcgaggg cgcgctggtg ctggcacggg cccggcgcag ccgggtaccg atcgagcagg
    12841 tcacccgccg catcggcgtc ctgctggagc aagggtgacc acaatggaca gggtggtgtt
    12901 cggtgcggcc ggatttctcg gccggtggac ggtgttgcac ctgctgggcc gaggacgcgc
    12961 ggtcgcggcc gtggtgcgcc gtcccggaga gctgcgcgac tggctggtgg cgcatggtgc
    13021 ggccgtcgat cgtctgacgc ttctgaccgg tgatctcaca aaaggtcccg ggttggggct
    13081 gagcccggct gacgacgaac ggctcgcggg cgtgcgggac gtgttcaact cggccgcggt
    13141 ctaccgattc ggcctgcggc gggaggaagc gacaccggtc aacgtcgatg gtgcggtgaa
    13201 tgtgctgcgg tgggcgaaaa cacgtccgaa cctgcgtcgc ctcgtgcacg tctcgggata
    13261 tcgggtcgga ctggatccgc ggccccggta tccgattccg gaagccgaac tggcggcgct
    13321 gtaccgcgaa aagggagcct acgaaggttc gaagttcgag gcggacgccg ccgtgcgcgt
    13381 gctcgcgggg gaactgggaa ttccgctgac cgtggtgaac ccgagtacgg tcatcgggca
    13441 ttcggtgacc ggtgaggccg gtcagtacct cggcctggcc gcgctcgtcc gcgatctgtg
    13501 gaccggcagg ctccccgtgc tgccgggaag tgcgcggacg ttcgtgccgg tggtgaccgt
    13561 ggaccacttc gccgagttca cggccgcgtt gcccgagcac gacgccatcg gcaggcactg
    13621 ggtgctcgac gagaacacgc cggagctgcc cgcgctggtg cgcctgctgg ccgggcacct
    13681 gggcgtccgg gcgccgaagc tccgggtgcc ggcgggggcg atccggcggc tgcccaccgc
    13741 gctgaccggt gccgatcccg agacgctgac cttcctgacc ggggatcggt acgacacggc
    13801 gtcggcggac cgggtggccc gtgccgccgg gctccggcac ccgccggtcg aaaccgcctt
    13861 gcggcggtgg gccgatcgcc tggtggcgga tggtttcggc gacacacccg ccgcgctccc
    13921 gggcggattc cagggggtcg ccgggtctcg tgcctatgtc gccggcgctc gtgtcacacc
    13981 ggatttcgtt ttcctgcaag gagtcgagcc gagcgcggaa ccgtggcggg aggtgatcgc
    14041 cgaactcgga ccggctccgg tgctggtcgc cgatctgccc ggactcggcc gatcggcgcc
    14101 gagtgacgtc actcctcgtg actggctcgc cgacctgctg gcgccggtcg agacccggcc
    14161 ggtgctcgtt gtgcacccgg ccgccgccgg tcccgcgatc cggtgcgcgg cagcgcatcc
    14221 cggccgggtg gcggccgttg tggtggtgcc gccggagttc gtcccggccg ggagcgcggc
    14281 gggaccgcgt cgccccggtg ccgcccggcg gacggcgcgg tggttgcggg cggcgaacga
    14341 gccgggtgaa cgggaggcag tgcgggtgct cggcgagtcc gttccggtgc ggtggatgac
    14401 cggggacgcg agcccggcgg cggtcgcgcg ggaatgccac ctcggcgcgg gggtgcgccg
    14461 aggtggcgat ccggcctgag cgggcctcag actccggcga cctgctggat ccagctgcgg
    14521 taccgggtga tgttcgtgta cgcggtgttg ttcgaacggt cgcttgtgga cgcgacgccg
    14581 acctggcggc cggaggcgaa catcgggccg ccggagtccc caccggcggt gatgccgtcg
    14641 atgcggttcg cgcacaccga gatgccgccg tagtagtcac tgcagttgac cgagttgacc
    14701 cgcacgttgg cgtacttcag gtagcgggac tggcagttga tctccgaacc gcaccggctg
    14761 gtcgcgcccc agccgtagac ctgcacggtc tgcccggtcg agacgtcgct ggtggtgccg
    14821 agcggggagt acgtggcgtt gaccgcggtg gtcagccgga cgatggccag gtcggccgag
    14881 ccgggatagc gggtgatcgt gtcgccggtg gccatcgtgc cgccgctttg ctggtccagg
    14941 ctgccgatcc ggaaggtgta ggtgccgctg ctcgccacgc agtgcttcgc ggtcaggatg
    15001 tactgcggcg cgatgatggt cgaggtgcag gtctggcggc cgttcgcgaa caggcgggcg
    15061 gcccacgggc cgctcgtggc gtactggccg ccgatgatga acggttgcac gccgccggtc
    15121 tcctcggcgg ccgaggtggc gggaacggcc aggccgagca gggccatcag ggcactgccg
    15181 atgagcacgg ccagtgagcg caggcgcatg gttccgactc gtttctgcgg cacgggatga
    15241 cggccgcgtt ccggggaggg ggtgcaccga ttctcgaacc ggaaagcgcg gccccggaac
    15301 cgacgaaagt cgggtggtcc agaccagcag tacctaatca tcggccgtcg tgcgatagcg
    15361 gtatagcgcc ggtgttatcc gtatcactgg gccattcgga cgccggtcac agccgggtga
    15421 acaacgtgta ggcggcgacc accaggctgc cgcacagggc ggcgagcagc acggcgcgca
    15481 gggtcagggt gtccgcggtg gaacggcgca tgggggtggc ctccggtgac tcggtgggga
    15541 cggtcatgcc ccaccgacct cccgctgtcc gcctcgtgac ggcgattcgc cgccgaaagc
    15601 gcgaatctcc ccttcgcggg tgatgccgcg actccgacac ccagggtgat cacttgctca
    15661 ccaaaggtgc cgacggcggc ttcgggcaca ctattgcgac agtttatccg gtgccgatga
    15721 aatttcgatg aaatggcgag cggttaccat tttatggact cgtatcgaca attttattgt
    15781 acgattttcc ggtggaaggc agattcaccc cgctggccgc cgaagacccg cgtgaagtcg
    15841 gtggttaccg gttgcgggcc cggctgggcg tgggcgggat ggggcgggtg tacctggcgt
    15901 tcagccccgg cggacgggcg ctggcgatca aggtggtccg cgccgagcac gccgaggacg
    15961 aggagttccg gcggcggttc gagcaggaga tcgccgccgc gcggcgggtg cagggcatgt
    16021 acaccgcgga ggtggtggac gccgacgcca cggcggccgt gccgtggctg gccacggcgt
    16081 acgtgcccgg tccgtcactg cgccaggccg tcgccgagca cggctcgctg ccgtccgaaa
    16141 cggtcttccg gctggtggcg ggggtggcgg agggactggt cgccgtgcac gcgtgcgaca
    16201 tcgtccatcg cgacctgacc ccggccaacg tgctgctcgc cgaggacggc ccgcgggtca
    16261 tcgacttcgg catcgcgcac gcggcggcgg ccacttcgct gacgcgcagc gggatcagca
    16321 tcggcacacc cgctttcatg gcgcccgagc aggtccgcgg ccgtcccgcg acggccgcca
    16381 ccgacgtgtt cgcgctgggg catctcgcgg tgttcgccgc caccgggcac ccggccttcg
    16441 gtgaaggcaa ccgggacgcg atgttctacc ggatcctgtc cgaggaaccg gagctgaccg
    16501 gctgcccgga ggacctccag ccgatcgtac ggcgctgcct ggccaaggaa ccggacgacc
    16561 ggccgtcgct ggacgaggtg ctggcggagg tcgccgggca cgcggaaccg cgcctgcccg
    16621 gcgactggct gcccgacggc gtcacccagg cgttcaagcg ctacgacacc gcgctctaca
    16681 ccgtccacga gacgaagaag aagcccggac aggagaagaa gccgaagcag gagaaaaagc
    16741 cgcagggaga caagaagccg cagcaggaga agaagccaca gcagggcaag tcgcagcggg
    16801 acaacaagcg tgcctctcct gtcggtggcg tgatcgcggt cgccgccctg ctcgcgatcc
    16861 cggtgatcgg cgcgatcggg ccggaaaagg tgctgaacgc ggcggacgag ttcttcagcg
    16921 cgaactcgac cagcaccacc acgaagcgcg ccaccggcac caccacgacc aaacggaccg
    16981 ccgccaccac cacgcgcaag gcctccaccc ggaccaccac gaagaagacg accaccacca
    17041 cgacgagggg cgcctgggag gggtgctccg aggcggcgga ggccttcgaa accctggagg
    17101 agacccgggt cagcgacgac cggaaggtca acgccgccgc ctaccggaag ctggcgaaca
    17161 gcctggacag catcgccgac accgcgggat ccgcgatcga ttcgaccctg gagaagctgg
    17221 cgaacggcta ccaggacgtc gccgactacc tggcgtcggg caacaccgag gcgttctcgt
    17281 cactcgccgc cgacctgaac gacgacgcgg cgaacctgct ggaccggtgc cgcggctgag
    17341 gtctcagtcc gcgatcgtgc cgggcggcag cgggtgatcg ggcagctgga cgaaaacgcg
    17401 ttcgagccgt ccgttcacga tgtcgtcgtt gagcaggaag ccggagtcgc ggccgagcag
    17461 gtacgcgacg atggtgctgc cttcgctgcc cgggggccgc agccgcaggt gctcgaacac
    17521 gccccggctc gggttcgccc gccagaagcg gggcgtcagc gggtcaccct cgggaaggaa
    17581 ctcccagccg gtgaccgtca ccgcgcagaa gaagtcgaac tcgcgcccgg cgtagaaccg
    17641 ttcggcgtgc tcgtagatcc ggccgaggtg ctcgacggcc gcccgcacga gcaccccgtt
    17701 ccgttccatc agcggcaatt cgctgaggaa cgagatgtcc gcataggtgg cgtagagggg
    17761 cagctcgtcg aaatagccgt cgtaggtcat caacgcgtcg aaatcgagca gatccccttc
    17821 ggccagcagg cgctcgaagt cttcgcggaa ccggtcgatc tcagcggtca ccaggctctc
    17881 cctccacatc ggacgctatc accacgggtg cgtgcccggg ctctgcccgg cccactgccc
    17941 gcccgtcggc caagcgaacc cgtggtcgta ggcccattcg taggtgcgcc ggttccagcc
    18001 ggggtcgccg tcgtggaaac tgccgtccat gttcaggccc ggcgagccgt tgccccggcc
    18061 ctgcacgtgg tactggctgc ccggcacgtg cgcctgtggg gcgtcgaccc gcccgccctc
    18121 gagctgggga ggcacgttct gcccgcggtg gatctcgttg cccgcttggc ggacgagccg
    18181 ttcccgttcg gcctgcagcc gttcggcgat ccggtcgggg tggttctcgg cgtcctcgta
    18241 cagcttgttc catgcctcgc tgcgcctggc ttcgttggcc gggtcgttcg gatcgaggtt
    18301 gcgcagcgca tcctcggctt cctcgcaggt catcaggccg agcgggtcgg tcagccgcat
    18361 cgggtcggcg acgtaggcgt gcgggttcgg cgtgccgaac aggccgagcg ggtcgttgct
    18421 ctggtaccgc ccggtttccg ggtcgtagta ccggaagaag ttgtagtgca gccccgtttc
    18481 gtcgtcgtgg tactggccgg ggaatcgcag cggggtggtg gtccgctggt tcagcgcggc
    18541 gagcgcctcg ccccacagcg tggtctgcgc gcgccaggcg agctgcccgg cgtcgtcgac
    18601 caactcggtg ggtgtgccga cgagatcggt gacgatggcg tagaaccgcc ggtcgatctc
    18661 ggcctgcgga gcgtgctcga tctgcgtcac cgggcggttc cggccgtcga agtcccaggt
    18721 caccgcttca ccgtgcgggc cgatctgctc ggcgagggtc gagccgtccc aggtgaacag
    18781 cacctggccg gccaccgcgc cgtcggggcc gagccgctgc ttggcgatcc ggcggccgaa
    18841 cgcgtcgtag cggtagcgcc agtgggtgcc gtccggggtg acgacgccga ccagccggtc
    18901 ctcggcgtcc cagtggtagt gccagttgtc cggcttgcgg gacaggcgct tcttctgctt
    18961 cagcaccacc cggccctgcc ggtcgtactg gtagcgcacg tcaccggact cgtgcatgac
    19021 cgtgccggtc acccgcgcga ccgggacttc cggagccgac ggctcgcgga ccaggttgcc
    19081 ggcgaggtcg taggcgtagc gctcctgcct gcccggcgcg tccaccgcgg tgatccggcc
    19141 gatcgggtcc accccgaagt tccgcgtgcc gccgagcgcg tcctggatgg cgagcaccgc
    19201 gtcgtcggca cggtaggtgt agtgccgctg ctgcaccacg gtcgcctgcg gcgcgtgccc
    19261 ggtcaccgtg ctgacggtct ggccggccag gcggtgcctg ttgtcccatt cgctggccat
    19321 gatcaggccg gtgtcgagca gcctttcgac ctcccggccg gccacgtcgt agccgaacga
    19381 cagcgtccgc ccgccgctga ccaggcgcga ggcccggccc agctggtcga actcccaggt
    19441 gctctcctgg ccggccgggg tccgccggtg gaccatccgg cccgcggcgt cgtaccggta
    19501 ggacatggtg cggccgttga ccgtctcggc gaggacccgg ccgctcgcgt cgcgccgcat
    19561 ggtcacctcc gcgtcggcgt tgaccgcccg caccagggaa cccgcttcgt cgaattcgaa
    19621 ggtggacacg tccgaaccac tgtgcctcgc ggcgatccgt ccgagctggt cgtacacgaa
    19681 gctcgttgtc tcgcctgccc cgttgaccac gctgaccagc tgaccggcgg ggtcgtaggt
    19741 gtagcggagt tcgcggccgt tgtagtcggt ttcgccgacg cggttcccgg cggcgtcgta
    19801 gtggtaccgc cagaccaggc ccgccgcgtt ccgcaccgcg gtgatccgga gattggtgtc
    19861 gtactcgaac tcggtgcgcg ccccggtggg accggtgatc gccgagacca ggtcgaagtg
    19921 ggtcgtctcg gtgtgcgtcg actggccgag cgcgtcgatg tgctcgaccc tggcgccttc
    19981 gccgtcgtag cgccaccgct cgaccgtgcc gtcggcgtag gtcctggcca gcagcttgcc
    20041 ttcgacggtc cagctgatcg aggaccggtt gcccagcggg tcgacgacgg tggacagcct
    20101 gccgaactgg tcgcgggtgt acctggtggt cgcgccgagc gcgtcggtca ccgccaccgg
    20161 cagcccggcc gcgctgacct cgaggcgcgt ggtggcgccc agcgggtcgg tcttgccgac
    20221 caggttgccg cgctcgtcac gcaggtaccg ggtgaccgcg ccggagggtt cggtcgccgc
    20281 catgatgttg ccgcgctcgt cgtagtcgta gcgccacacc gcgccgcccg ggtcgacctg
    20341 cgtggtgggc aggccgaact cgttgtactc ggccaggccc tggctgccgt cgggccgggt
    20401 cgcggtgacc aggttgccgt gctcgtcgta gtcgaaccgg gtgacgcggc cgagggggtc
    20461 gcggcgggtg accagctggt cgcggtcgtt ccattcctgg tgggtgacgt tgccgagcgg
    20521 gtcggtcagc tcgacgacgt tgcgtgcttc gtcgtagcgg taggtggtgc ggttgccgag
    20581 cgcgtcggtg aagacggtgg tcatggcgtc ggcgtcgtag tcgaacgtgc cgttgaggaa
    20641 accgcccgcg ccttcgttgg ccacgcagcg gccccgcgcg tcgtagcggt agccgtacca
    20701 ggaaccggtc cggtcgtccc agcggaccag ccgcccgtcg ctgtcgtagc tgaactggag
    20761 cgccttggtc gaggaattga acaccttggc gaggcggccg cggtcgtcgt actcgtaccg
    20821 gacgacctcg atgtcggcgt tggactcgcc ggattcgccg gccagcacga gccgggcgat
    20881 ccggccgccg ctttgctcga cgagcacgcg gtagccaccg ctgtgccgca gttgcgtgag
    20941 ggtgccgccg ggggtgtagt cgaggtcgat gcggttccgg ttgcggtcct cgaccgcgtc
    21001 caggcggcca ccaccggcga agtgcaggaa ctggttggcg tccggtttgc tgatcaggta
    21061 accgtcgccg gtcctggtca acggccacc
//
