LOCUS       NZ_CP045480            22029 bp    DNA     circular CON 15-AUG-2024
DEFINITION  Amycolatopsis sp. YIM 10 chromosome, complete genome.
ACCESSION   NZ_CP045480
VERSION     NZ_CP045480.1
KEYWORDS    RefSeq.
SOURCE      Amycolatopsis sp. YIM 10
  ORGANISM  Amycolatopsis sp. YIM 10
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1  (bases 1 to 10312959)
  AUTHORS   Ruckert,C., Guerrero-Garzon,J.F., Zehl,M., Rezaei,S., Selivanova,G.,
            Urban,E., Busche,T., Kalinowski,J., Cao,Y.-R., Jiang,Y., Jiang,C.-L.
            and Zotchev,S.B.
  TITLE     Complete genome sequence of Amycolatopsis sp. YIM 10, isolated from
            a rare earth mine
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 10312959)
  AUTHORS   Ruckert,C., Guerrero-Garzon,J.F., Zehl,M., Rezaei,S., Selivanova,G.,
            Urban,E., Busche,T., Kalinowski,J., Cao,Y.-R., Jiang,Y., Jiang,C.-L.
            and Zotchev,S.B.
  TITLE     Direct Submission
  JOURNAL   Submitted (11-OCT-2019) CeBiTec, Uni Bielefeld, Sequenz 1, Bielefeld
            33615, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2.8
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 80.5x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_009429145.1-RS_2024_08_15
            Annotation Date                   :: 08/15/2024 04:03:36
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,775
            CDSs (total)                      :: 9,711
            Genes (coding)                    :: 9,634
            CDSs (with protein)               :: 9,634
            Genes (RNA)                       :: 64
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 49
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 77
            CDSs (without protein)            :: 77
            Pseudo Genes (ambiguous residues) :: 0 of 77
            Pseudo Genes (frameshifted)       :: 22 of 77
            Pseudo Genes (incomplete)         :: 65 of 77
            Pseudo Genes (internal stop)      :: 1 of 77
            Pseudo Genes (multiple problems)  :: 11 of 77
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 18:01:44
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1208850
            Orig. end                         :: 1230879
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP045480.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Annotated using prokka v1.11 from http://www.vicbioinformatics.com.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22029
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="redox-cofactor"
                     /region_number="2"
                     /rules="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /tool="antismash"
     cand_cluster    1..22029
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(PF04055 and (TIGR04085 or SPASM))
                     and (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /kind="single"
                     /product="redox-cofactor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22029
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12029](-)"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12029)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
     gene            complement(607..2103)
                     /locus_tag="YIM_RS05945"
                     /old_locus_tag="YIM_05985"
     CDS             complement(607..2103)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1294: Nitrilase/cyanide hydratase and apolipoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007033930.1"
                     /locus_tag="YIM_RS05945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YIM_05985"
                     /product="nitrilase-related carbon-nitrogen hydrolase"
                     /protein_id="WP_153029368.1"
                     /transl_table=11
                     /translation="MTKSKLLWWSGVVLLALTVHTNWASPLAAWLFAIPLLLFSLRQGA
                     RPGLLKVLGALALGTFAWLAATSLLFVPAALLAFAGLTLLQWLAFVAHRLVSPRLPGFL
                     GTLVFPTTLAGAEYLFPLLIRFGDYGALGSTQHANLPLLQLASVTGVYGITFLVGWFAS
                     TAVWAWETRDARRFVVYGVVLAAVFAAGAARLTFFAPTETSVRVAAVSPSRNADERSAT
                     ALSTMDVEYWRAAEVAAADPGAIRAALAPVTEDLLAQTRGQAMAGAKIVLWPETHARVM
                     ERDHRELLDSAAVIARETGAYVNLAYAMYTGEAPNIRNLSTMITPAGEIAWTYDKSRPT
                     PMEPMTPGPGDVPTVDTPYGRLAGVICYDADFPHLMRQAADKGADLLLVPANDWAEFSE
                     LHAEKAVFRNVEYGYSMLRDSSHGLSTATDAQGRVLASTDWFRTDQQTLVANLPLQSRT
                     TTIYSTIGDVFAWLCLAGAAGLALTALRRTAPVEGAYAAG"
     gene            complement(2169..2858)
                     /locus_tag="YIM_RS05950"
                     /old_locus_tag="YIM_05990"
     CDS             complement(2169..2858)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1071: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005440547.1"
                     /locus_tag="YIM_RS05950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YIM_05990"
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_153029369.1"
                     /transl_table=11
                     /translation="MPLADIEPVNRESTAGIIARQLRDAIMNGALPPGTQLGETELASR
                     FQVSRGPLREAMQRLVSEGLLRSERHRGLFVIDLEPDDVYDIYVARAAIERAAALRIMR
                     GDREKAAAALDEIVRAMAAAADEDDPTALSDADLRFHEVLVAESGSRRLMRMTQTLLIE
                     TRMCLSMLQQTYQRVEERVDEHNQLIDAIRAGDEESVLKQLEAHMEDAIQRLLPGTSLH
                     GIPGTPD"
     gene            complement(2860..3591)
                     /locus_tag="YIM_RS05955"
                     /old_locus_tag="YIM_05995"
     CDS             complement(2860..3591)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020670598.1"
                     /locus_tag="YIM_RS05955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YIM_05995"
                     /product="aspartate/glutamate racemase family protein"
                     /protein_id="WP_153029370.1"
                     /transl_table=11
                     /translation="MTTIGFIYPDHAAEDDYPLAEHLLGPEFRLPVEHIYGTDLHAVPE
                     LLDLGSPERLKEGAGLLAKHEPDAVIWACTSGSFVYGWEGARKQADQLAEAAGVPSTST
                     SFAFVEAAKALGVRKVAVAASYPDDVARLFVEFLAAGGVEVLTMSSADIDTAAEVGELS
                     PEAVIELAVSHDHPEADAVLVPDTAMRTLGVLGAIENRLGKPVLTANQVTIWEGLRQAG
                     VSVTSGELGALFTRTVREKGN"
     gene            complement(3637..4365)
                     /locus_tag="YIM_RS05960"
                     /old_locus_tag="YIM_06000"
     CDS             complement(3637..4365)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020421574.1"
                     /locus_tag="YIM_RS05960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YIM_06000"
                     /product="Asp/Glu/hydantoin racemase"
                     /protein_id="WP_153029371.1"
                     /transl_table=11
                     /translation="MPVFDGPLAQRGIGVIAPFDLALERELWRWVPMEVSLHLARTPYE
                     PVPVSMEMAQLVSDSKHLAAATRDVLHVEPEVVAYLCTSGSFVNGIDYERSLCKAICDA
                     GAPDAVTTSGALAEVLHRLDLHKISVLTPYDQDLTGKLHDFLTELDVKTVSSDHLGLGG
                     GIWKVSYRTIAERILAADHSEAEAVFVSCTNLPTFDLIEPLEAALGKPVLTANQLTMWA
                     CLMRMGLPLVGPGKWLRDVS"
     gene            4478..5458
                     /locus_tag="YIM_RS05965"
                     /old_locus_tag="YIM_06005"
     CDS             4478..5458
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 2-Hacid_dh_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1072: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009155860.1"
                     /locus_tag="YIM_RS05965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YIM_06005"
                     /product="D-2-hydroxyacid dehydrogenase"
                     /protein_id="WP_194240055.1"
                     /sec_met_domain="2-Hacid_dh_C (E-value: 4.1e-48, bitscore:
                     162.2, seeds: 135, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIGTESPVLAVLCGDQHPPDMDSIEHVAAVRYTDEAGLKKALHGA
                     DILFVYDFLSTAVPGAWEAADKLRWLHIASAGVDPVLFPGLRESDVVLTNSRGVFDDAI
                     AEYVLGVVLAFAKDFARSRQLQQERTWLHRETERVSGRRALVVGTGPIGRSIARLLRAA
                     GLSVAGAGRTARESDPDFGVVHASAELTTHLGDYDYVIAVAPLTEQTKGMFDARAFAAM
                     KPGARFVNVGRGELVVTGDLIAALRDGRPAGAALDVFDTEPLPSDSPLWTMENVLISPH
                     MSGDFIGWRNTLVEVFAGNFERWRTGQPLRNVVDKGLGYVPSGSN"
     misc_feature    4589..4591
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    4601..4603
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            5467..6876
                     /locus_tag="YIM_RS05970"
                     /old_locus_tag="YIM_06010"
     CDS             5467..6876
                     /EC_number="3.5.1.4"
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1105: amidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009155859.1"
                     /locus_tag="YIM_RS05970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YIM_06010"
                     /product="amidase"
                     /protein_id="WP_153029372.1"
                     /transl_table=11
                     /translation="MNESGTLLTASELVAAYGSGELSPVEATQASLDAIAERDGELNAY
                     CLVDADSALEQAKLAEQRWREGHPIGWLDGVPTSIKDMFLSQGWPTQRGSRCIDPAGPW
                     EVDSPVTARLREHGLVLLGKTTTPELGWKAVTDNTLNGITRNPWNPALTAGGSSGGSAA
                     AVAAGMGELSVGTDGGGSVRIPASFCGIVGFKPTHGRIPLFPASPFGPLGHAGPMARSV
                     DDVALLLDVLALPDHRDPSALAPPASSYREAVRRDVRGVNAAYSANLGYVDVDPEIARI
                     TLAVVAALNEAGLRIEETDPGFADPLDAFDVLWSTGAAKWLDTFPAGSEELIDQGLRRV
                     WEHGHTFSASDYLEASAVRAALGIHMGEFHLRHDVLITPMMPISPFEAGHDVPPGSSYQ
                     TWPEWTRFTYPFNLTQQPAISVPIGFTAAGLPVGLQIVGPRHSDDLVLAVAKLVEEVKP
                     WATDRPAAPRR"
     gene            complement(7305..8564)
                     /locus_tag="YIM_RS05975"
                     /old_locus_tag="YIM_06015"
     CDS             complement(7305..8564)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005447462.1"
                     /locus_tag="YIM_RS05975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YIM_06015"
                     /product="MFS transporter"
                     /protein_id="WP_153029373.1"
                     /transl_table=11
                     /translation="MSLREPLQHRSFRWLLAGRTGAELANAIAPVALAFAVLDLTGSVV
                     DLGLVVGVRSLANVILLLFGGVLADRLPRALILQGTGLAAALTQGLIAASVIGGFASIP
                     LLLALSALNGGVAAMSLPAAASLTPQTVPATLLTPANALARMGANTGRILGAALGGMLA
                     AGVGAGWAIAVDAGIFLLSAAGYRGVRIAARVRAERSHPLKDLVEGWREFTARSWVWIV
                     VAQFTVVNAVIMGSHAVIGPKVADDTVGRAAWGFILAAETLGAFIGGVLAARWQPRHAL
                     LIGVAVIAVEAVPLVTLAEAPSLVPLLATMFLAGIAIEQFVVAWDVSLQENIPEDKLAR
                     VYSYDMLGSFIAMPVGEIAAGPLAERFGADTTLLAGALLVLVSTALALCSRQIRGLTRK
                     SATPSDVTGAVPPADRSPAP"
     gene            complement(8561..9079)
                     /locus_tag="YIM_RS05980"
                     /old_locus_tag="YIM_06020"
     CDS             complement(8561..9079)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007033803.1"
                     /locus_tag="YIM_RS05980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YIM_06020"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_153029374.1"
                     /transl_table=11
                     /translation="MPEKTSLVELRVLAHPLRLRILSLLTGAAMSAAEAARELQDTQAN
                     VSYHLRRLHEAGLLEVAEEVRIHGGLAKRYRHVPGNAPRWNHEDHEGEQLFAETLAGEL
                     RRRTVDREPSGRSAVTDAEVWLSPADWERAVELANELGDLLHSEAQPPRTPETRRVSAT
                     IALFEMVRP"
     misc_feature    complement(9112..9127)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.8"
                     /tool="antismash"
     misc_feature    complement(9114..9127)
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: medium, score: 20.9"
                     /tool="antismash"
     gene            complement(9141..10004)
                     /gene="pqqB"
                     /locus_tag="YIM_RS05985"
                     /old_locus_tag="YIM_06025"
     CDS             complement(9141..10004)
                     /codon_start=1
                     /gene="pqqB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013229609.1"
                     /locus_tag="YIM_RS05985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YIM_06025"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqB"
                     /protein_id="WP_153029375.1"
                     /transl_table=11
                     /translation="MKVLLLGTAAGGGFPQWNCACALCTSDAPPRTQDCVAISADGRGW
                     YLLNASPDIRAQILASPVLRAGPGPRETPLRGALVTDAELDHTLGLVMLREAPSFGVWG
                     PDAALHAMRGALPVGRYGDWTFSPVEPEIGGLRVRALPVSDKKPKYARDSTSDGPWVVA
                     YRIEDPSTGGVFVYAPCLATWPPGFGEFTDGADYVLLDGTFYGADEMSGATRAGVGSQA
                     QRAMGHVPISGADGSLARIRDLPGPRWAYTHLNNTNPALAPDSPEHKEVLAAGAELPLD
                     GTLLTL"
     gene            complement(10001..11092)
                     /gene="pqqE"
                     /locus_tag="YIM_RS05990"
                     /old_locus_tag="YIM_06030"
     CDS             complement(10001..11092)
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_process="GO:0018149 - peptide cross-linking [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: SPASM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR04085"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016336985.1"
                     /locus_tag="YIM_RS05990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YIM_06030"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqE"
                     /protein_id="WP_153029376.1"
                     /sec_met_domain="PF04055 (E-value: 1.1e-20, bitscore: 73.8,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 7.1e-10, bitscore: 38.4,
                     seeds: 166, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 8.6e-11, bitscore:
                     41.2, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDVKPAEPPLGLLAELTHRCPLHCPYCSNPLELITRDGELGTEQW
                     LSVLSQARELGVLQVHMSGGEPLARPDLPELVSHASDLGCYVNLVTSGLGLTGKRLDDL
                     AERGLAHIQLSVQGADAERADRLAGTRAHDHKIATAALIKESGLPLSVNVVLHKQNHDQ
                     LAGLIALAERMGADRLELANTQYYGWALKNRTALMPTREQLAAAEPIVRAATERLLGTM
                     EIIYVVADYYEPYPKPCMYGWGARQLTVAPNGDVLPCPAATAISTLELDNVTRKPLHDI
                     WYGSTSFNAYRGEDWMSETCRSCDRRGTDHGGCRCQAFLLTGDAAATDPVCSRSPDREI
                     VDLILSAPPPAVEPELVMRRVAR"
     gene            complement(11083..11334)
                     /gene="pqqD"
                     /locus_tag="YIM_RS05995"
                     /old_locus_tag="YIM_06035"
     CDS             complement(11083..11334)
                     /GO_function="GO:0048038 - quinone binding [Evidence IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003079638.1"
                     /locus_tag="YIM_RS05995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YIM_06035"
                     /product="pyrroloquinoline quinone biosynthesis peptide
                     chaperone PqqD"
                     /protein_id="WP_370468960.1"
                     /sec_met_domain="PqqD_RRE (E-value: 2.6e-24, bitscore:
                     83.9, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 1.1e-11, bitscore: 44.0,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIPRLRRGVRLTYDKVRETHVLLYPEGVLVPNKTAAAVLELCDGH
                     TSVADITAALGKQYRGVREADVNGVLSRLAERRVVEWT"
     aSDomain        complement(11092..11331)
                     /aSDomain="PqqD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing protein in a pyrroloquinoline
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_YIM_RS05995_PqqD_RRE.1"
                     /evalue="7.70E-27"
                     /identifier="RREFam006.1"
                     /label="YIM_RS05995"
                     /locus_tag="YIM_RS05995"
                     /protein_end="81"
                     /protein_start="1"
                     /score="83.9"
                     /tool="antismash"
                     /translation="IPRLRRGVRLTYDKVRETHVLLYPEGVLVPNKTAAAVLELCDGHT
                     SVADITAALGKQYRGVREADVNGVLSRLAERRVVE"
     gene            complement(11337..12029)
                     /gene="pqqC"
                     /locus_tag="YIM_RS06000"
                     /old_locus_tag="YIM_06040"
     CDS             complement(11337..12029)
                     /EC_number="1.3.3.11"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR02111"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005150533.1"
                     /locus_tag="YIM_RS06000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YIM_06040"
                     /product="pyrroloquinoline-quinone synthase PqqC"
                     /protein_id="WP_153029378.1"
                     /sec_met_domain="TIGR02111 (E-value: 7.3e-85, bitscore:
                     283.2, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAPLSHEEFAAALRGLSHRYWGTHPFHHRMHAGELSERELRIWA
                     ANRWYYQRMIPQKDAAIISNCPLPEVRRQWLPRLVYHDGAAPGEGGIERWLRLCEAVGL
                     SREEVLDERHVAPGVRFAVDAYVTFARTKPWVEAVASGLTEMFSGHLMKRRVADMLANY
                     DWINRADLAYFTNRIDAVSGEGQATVDLVLRHCVTREQQDAAIAALSFKCDVLWSILDA
                     IERAAAKE"
     gene            complement(12100..12195)
                     /gene="pqqA"
                     /locus_tag="YIM_RS06005"
                     /old_locus_tag="YIM_06045"
     CDS             complement(12100..12195)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007033797.1"
                     /locus_tag="YIM_RS06005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YIM_06045"
                     /product="pyrroloquinoline quinone precursor peptide PqqA"
                     /protein_id="WP_113694224.1"
                     /transl_table=11
                     /translation="MIETATEVWTTPDFVEYETPMEVTAYAARME"
     misc_feature    complement(12163..12178)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 23.23"
                     /tool="antismash"
     misc_feature    12273..12282
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.18"
                     /tool="antismash"
     misc_feature    complement(12343..12356)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 14.32"
                     /tool="antismash"
     gene            complement(12364..13731)
                     /locus_tag="YIM_RS06010"
                     /old_locus_tag="YIM_06050"
     CDS             complement(12364..13731)
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008374 - O-acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020641036.1"
                     /locus_tag="YIM_RS06010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YIM_06050"
                     /product="wax ester/triacylglycerol synthase family
                     O-acyltransferase"
                     /protein_id="WP_153029379.1"
                     /transl_table=11
                     /translation="MPLMPVTDSMFLLVESREHPMHVGGLQLFRKPEDAGPNYLSEIRR
                     RLLERSEVSRAFRRRPARPVNTMGYAAWAEDVELELDYHFRHSALPQPGRIRELLELTG
                     RWHSTLLDRHRPLWEVHLVEGLRDDRFAMYSKVHHALMDGVSALRQMQSTLSDSPDERD
                     SPPPWSGPKTQGVRRNRRDPVSLLTGTRQSLAQLAKLPRAAVKVAGEAFREHSLTLPTQ
                     APKTMLNVPIGGARRFAAQSWSLDRVRRVATAAGVSRNDVVLAMCSGALRDYLIEQRAL
                     PDTAMVAMVPVSMRKRAETGEAGGNAVGALLCNLATDRSDPAERLKLIHQSMRDGKRIF
                     SDLTPLQALILSGINVAPLGASTIPGFVNNTRPPFNLVISNVPGPRKTMYWNGAQLDGV
                     YPASVLLDGQALNITLTSNGDNLDFGITGCRRSVPHLQRILTHLDTALAELESAVA"
     gene            13840..14997
                     /locus_tag="YIM_RS06015"
                     /old_locus_tag="YIM_06055"
     CDS             13840..14997
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1103: FAD dependent oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005150529.1"
                     /locus_tag="YIM_RS06015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YIM_06055"
                     /product="FAD-binding oxidoreductase"
                     /protein_id="WP_153029380.1"
                     /sec_met_domain="DAO (E-value: 6.8e-64, bitscore: 215.8,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MANLPERAGVVIVGGGVIGVSCAFQLAEAGVDVLLLERGALGAGS
                     TAKAAGGVRSSFTSRVNIELGLRGLAEFERFPARFGQEIDFRRDGYLYLITDPADLPRF
                     ERGVALQNSLGVASRVIEPAEAVRHNPLISVDGVHAAVWSPEDGRATPDAVVQGYARAA
                     RALGATLCTGVEVVGIDRGDEQIRAVQTSRGVVRTEVVLCAAGAWSARIGELAGCPLPV
                     SPERRQVVFTGSIPGRPESVPLTVEMPSAFYLHPEGDGLALSLPGGPGDAGFDSRYEPG
                     EWLPALAEAAMRRAPSVLDAGIRTAWAGLYEMTPDRNQVVGEAAGVSRFLYATGFSGHG
                     FQMGPAVGAVMRDLYLGREPEIDVSSLDVRRFDGGVTTRAEYNIV"
     gene            15039..16691
                     /locus_tag="YIM_RS06020"
                     /old_locus_tag="YIM_06060"
     CDS             15039..16691
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055: pyruvate oxidase/decarboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009082801.1"
                     /locus_tag="YIM_RS06020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YIM_06060"
                     /product="thiamine pyrophosphate-binding protein"
                     /protein_id="WP_153029381.1"
                     /sec_met_domain="TPP_enzyme_N (E-value: 4.5e-50, bitscore:
                     168.7, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 3.1e-24, bitscore:
                     84.6, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPVVSHAKPKSGADQLADALGELGVGVAFGLPGVHNLPIWEALAD
                     TGIQLLGVRHEQTAAYAADGYARATGKLGVAIVTTGPGAANTLAAVGEAQASGSPVLVI
                     ATDIPSTLRRPGTVRGVLHETSDQAAMFAPLTKGQYTVGGPEEIAGATLAAARLALRPQ
                     SGPVYLGIPTDFLSAAAKRAPDPADLTPVPEPLDLGRARELFERAERPLIWAGGGALRA
                     GAGAVIGELAEKLAAPVLTTFAARGLLPPEHPCLAPNSVHTPEVGALWDEADLVLGVGT
                     DFDGLMTQNWLMPQPPTLVTVNIDAADAAKNYQPDLNLVGDARAVVTALLGELPAKDGL
                     EKLTARLRRMSAAVRRRIREDEPQAADFLGTLEEVLPEDAILVSDMCIAGYWIGGFHRI
                     PGPRKLAYPMGWGTLGFGFPASIGSAAAGAGRAVCVTGDGGFLYGVGDLATAAQEDLRV
                     TVVVVEDGGYGMLRFDQEHSGLPHRGVDLVGPDFVAMAKSFGVRSERVKGFGRAFRRKL
                     SAFIQADEPNVLVVEAAMRPPLNTSPRWYRKER"
     misc_feature    15129..15131
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            16691..18724
                     /locus_tag="YIM_RS06025"
                     /old_locus_tag="YIM_06065"
     CDS             16691..18724
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005150523.1"
                     /locus_tag="YIM_RS06025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YIM_06065"
                     /product="hydantoinase/oxoprolinase family protein"
                     /protein_id="WP_194240056.1"
                     /transl_table=11
                     /translation="MTLRVGVDIGGTFTDLCVLDDSGVVAIGKALTTHDEPARAVGELL
                     RDVVPDPSQVDKLVHGTTLVTNALIERKGSKLALLATAGFRDVLEMRREHRYELYDLQI
                     ELPEPLVPRHLRFDVPERILADGSVQTPLDEEYVARLGTELAERGIEAVAVCFLHSFTN
                     PEHERRVRAVLAEVAPGLRVALSSEVVPEIREFERASTTAANVYVQDLTERYLRDLEQR
                     VHRAGIGPAPHIMLSNGGIATVDTAARYPIRILESGPAGGALAASAFGAAAGEADLLAF
                     DMGGTTAKLCMISDGAPLVTHEFEVDRVYRLLPGSGLPVKVPVTDMIEIGVGGGSIARI
                     DALGLLTVGPDSAGSEPGPVCYGRGGTEPTVTDADLVLGYLDPGYFLGGEMALDLDAAR
                     EVIQRRIAEPLGVGLAEAAYGIHAHVNEDMANAARVHAVERGKDPARLPMFTFGGAGPV
                     HGVGVARALGARQVVAPPAAGVMSAVGFLTAPLAFDFVRTSRAGVDELSWSEVDALFAE
                     MEREGEELLKASGVDTVTHSRIAEMRYAGQGYEIRVPVNQGEWPATLVNDFTEAYRELY
                     RRTGPDVGVEVLNWRVVSSGPVPRVNLRLSVEAGTGEARKGSRQAYFPGGFVDTAVYDR
                     YRLRADDRIDGPAIIEERESTLVIPPDASCTVRADSSLVVTP"
     gene            18721..20412
                     /locus_tag="YIM_RS06030"
                     /old_locus_tag="YIM_06070"
     CDS             18721..20412
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013229601.1"
                     /locus_tag="YIM_RS06030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YIM_06070"
                     /product="hydantoinase B/oxoprolinase family protein"
                     /protein_id="WP_153029382.1"
                     /transl_table=11
                     /translation="MIVDPILVGVVGNRLHSILAEQQNALVNTAFSSVVRESLDLACAV
                     FDSRGEMIGQSVGGTPGHINAMATGMHHFVAAFPPEQLAPGDVLLTNDPWQTAGQINDI
                     TVATPVFHRGRVIAWFASCCHAPDIGGRLVSAEANEVFEEGLRLPIMKFLRAGEVNAEL
                     EAIIRANVRTPEETIGDLYAQVAGNDVGAASLVRLAEEFGLDSIDEIAAEIMNRSERAL
                     RDAIAALPDGTFRSELRTDGFGEEEVLLKVALTVRGEDIDIDFAGSSPQSKHGINVVLN
                     YTRAYASFAVKAAIAPGVPHNAGSFRPVHVTAPAGSVLNCLPPAPVASRHLIGHFLPSL
                     LIGALDGRMAHSADALWMTIWRGQSHEDGREFMLNVFQTGGIGARATKDGLNTTGFPSG
                     LRATPTEVIETMAPLVQTRRVLRTDSGGAGTHRGGLGQSTTVTARGDISWSVNGNVDRT
                     SSPAIGVHGGLDGAPGRFGLADGTALPGKRRVTLEPDAVVDVVLPGAGGYGDPRERDPE
                     RVLADVVDGYVSIEAARDVYGVEIRYTGRPDALVRLPADYQIVERD"
     misc_feature    19465..19467
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            20414..21205
                     /locus_tag="YIM_RS06035"
                     /old_locus_tag="YIM_06075"
     CDS             20414..21205
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070403 - NAD+ binding [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (7-161). E-value: 3.1e-07. Score:
                     22.4. Matches aSDomain:
                     nrpspksdomains_YIM_RS06035_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004561815.1"
                     /locus_tag="YIM_RS06035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YIM_06075"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_153029383.1"
                     /transl_table=11
                     /translation="MGRVEDKVVVVFGGARGIGLASVKEFLAEGAIVRSSDIREPAEEI
                     GHQNFTHTTVDATDEEAVQSFVEQVLGEHGRIDVLFGNVGIHLGKPLPETTLAEFDHIF
                     ALNVRTAFLATRAVLPHMIEAKAGSIVLTSSNGGMMGRPADPVYNATKHALVGLAKSLA
                     VAHAHLGIRVNTVNPGAIDTDMLRSTLASPDDFEAKQHQLTASTPAARVGEAWEVAKAV
                     LFLASDESRFINGAVVPVDGAKAAGAMPGNRYSLDFELGVR"
     aSDomain        20435..20896
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_YIM_RS06035_PKS_KR.1"
                     /evalue="3.10E-07"
                     /label="YIM_RS06035_PKS_KR.1"
                     /locus_tag="YIM_RS06035"
                     /protein_end="161"
                     /protein_start="7"
                     /score="22.4"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VVVVFGGARGIGLASVKEFLAEGAIVRSSDIREPAEEIGHQNFTH
                     TTVDATDEEAVQSFVEQVLGEHGRIDVLFGNVGIHLGKPLPETTLAEFDHIFALNVRTA
                     FLATRAVLPHMIEAKAGSIVLTSSNGGMMGRPADPVYNATKHALVGLAKS"
     CDS_motif       20438..20506
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_YIM_RS06035_0001"
                     /evalue="5.50E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="YIM_RS06035"
                     /protein_end="31"
                     /protein_start="8"
                     /score="9.4"
                     /tool="antismash"
                     /translation="VVVFGGARGIGLASVKEFLAEGA"
     gene            21202..21900
                     /locus_tag="YIM_RS06040"
                     /old_locus_tag="YIM_06080"
     CDS             21202..21900
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1071: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005150516.1"
                     /locus_tag="YIM_RS06040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YIM_06080"
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_153029384.1"
                     /transl_table=11
                     /translation="MTSGDPSAVLAGDRSALARAGTAERVAQILRQRIAEGVFLPGTRL
                     AEPAISSALGVSRNTLREAFQLLAHERLAVRELNRGVFVRELTGPDIVDLYRIRRMVEC
                     AAVREAADRDGLVLTALVDALAEGKQAARDEDWQAVGTASIRWHQALSELSGSDRVAGT
                     MRQVLAETRLFFVLTENTQAFFEPYLARHEKIIGHLRRRRFDLAEQALERYLRDAERQL
                     LAAYHRRETP"
ORIGIN
        1 gatcgccgcc gagtacccgg atgtccacag tgaacagtgc catgtggacg ccttggcggc
       61 gcggatggtg cagcacccgg accggctgga cgtggtggtg gcgtcgaacc tgttcgggga
      121 catcctcagc gacctcgcgg cggcggtgac cggcgggctg ggcatggccc cgtcgggcaa
      181 catcaatccg ccgggggagc acccgtcgat gttcgaggcg gtgcacggca gcgcgccgga
      241 catcgccggg cagggcatcg cgaacccggt ggcccaggtg ctcgccgggg cgatgatgct
      301 cgaccacctc ggcgagaacg gggcggcgcg ggcgatcaac tcggcggtgg aaaaggtact
      361 cgccgacggt tcggtggcga ccccggacct cggcggcacc gccaccacca cggaactcgg
      421 caacgccatc gcggaggccc tcacctgaca tattcacggc acccgggagg gcgccgccgg
      481 taaccggccg caagacggga acaagacgcg gcgcaccgcc caaaccctcc accccgcctc
      541 ggtccacagc taaaaacacg gcttcgccgt agtcacagtg aaagaccggg gcgggggccc
      601 gcacacctat cccgcggcgt aagcgccctc aaccggggcg gtgcggcgca gcgccgtcag
      661 agcgaggccc gccgcacccg ccaggcacaa ccaggcgaaa acatcgccga tggtgctgta
      721 gatagtggtc gtccgcgact ggagcggcag gttggcgacc agggtctgct ggtccgtgcg
      781 gaaccagtcc gtgctcgcca ggacccggcc ctgcgcgtcc gtggcggtgg agaggccgtg
      841 tgacgagtcg cgcagcatgg agtagccgta ttcgacgttg cggaagaccg ccttttccgc
      901 gtgcagctcg gagaactcgg cccagtcgtt ggccggtacc agcagcaggt ccgcgccctt
      961 gtcggcggcc tggcgcatga ggtgcgggaa gtcggcgtcg tagcagatga ccccggccag
     1021 cctgccgtac ggagtgtcca cagtgggcac atcaccagga cccggcgtca tcggctccat
     1081 cggggtcggc cggctcttgt cgtaggtcca ggcgatctca ccggccgggg tgatcatggt
     1141 gctgaggttg cggatgttcg gcgcctcacc ggtgtacatc gcgtaggcca ggttcacgta
     1201 ggcaccggtc tcccgcgcga tcacggccgc gctgtcgagc agttcgcggt ggtcgcgttc
     1261 catgacgcgg gcatgggttt ccggccacag cacgatcttc gcgcccgcca tggcctggcc
     1321 gcgggtctgt gcgagcaggt cctcggtgac cggcgcgagg gccgcgcgga tggcaccggg
     1381 gtcggcagcc gccacctccg ccgcccgcca gtactcgaca tccattgtgg acagcgcggt
     1441 tgcggagcgt tcgtcggcgt ttcggctcgg gctcaccgcg gcgacgcgca cggacgtctc
     1501 ggtgggcgcg aagaaggtga gccgcgcggc cccggcggcg aacacggccg ccagcactac
     1561 cccgtacacc acgaacctgc gcgcgtcgcg ggtttcccac gcccacacgg cggtcgaggc
     1621 gaaccagccg acgaggaagg tgatgccgta cacgccggtg accgacgcga gctgcagcag
     1681 cgggaggttc gcgtgctggg tggagccgag cgcgccgtag tcaccgaagc ggatcagcag
     1741 cgggaacagg tattcggcac ccgcgagcgt ggtcgggaag accagggtgc cgagaaaacc
     1801 gggcaggcgt ggcgaaacca gtcgatgcgc gacaaaagcg agccactgca acagggtgag
     1861 cccggcgaac gcgagcaacg cggcgggaac gaagagcagg ctggtcgccg cgagccaggc
     1921 gaacgtgccg agcgcgagcg cgccgagcac cttgagcagg ccgggacgcg cgccctggcg
     1981 caggctgaac aacagcagcg gaatggcgaa cagccacgcc gcgagcggac tggcccagtt
     2041 ggtgtgcacg gtcagggcca gcaggacgac gccggaccac cagagcagct tcgatttggt
     2101 cacgggatga cgttacgaag cggggtgggg tcggcacatc gatcctccgt cgatgcgggg
     2161 cccctacttt agtcaggggt gccggggatc ccgtgcagcg aagtgcccgg caggaggcgc
     2221 tggatcgcgt cctccatatg cgcctccagt tgcttcagca ccgactcctc gtcacccgcg
     2281 cggatggcgt cgatcagctg gttgtgctcg tcgacccgtt cctcgacccg ctggtaggtc
     2341 tgctgcagca tggaaaggca catgcgcgtc tcgatcagca gggtctgcgt catccgcatc
     2401 agccggcggc tgcccgattc ggcgaccagc acctcgtgga agcgcagatc ggcgtcggac
     2461 agggcggtcg ggtcgtcctc gtcggcggcc gcggccatcg cgcgcacgat ctcgtcgagc
     2521 gcggcggcgg ccttctcccg gtcaccacgc atgatccgga gcgccgccgc ccgctcgatc
     2581 gcggcccgcg cgacgtagat gtcgtacacg tcatccggct cgagatcgat cacgaacagc
     2641 ccgcggtgcc gctcgctgcg cagcagtccc tcggagacca accgctgcat cgcctcgcgc
     2701 agcggccccc gcgagacctg gaaccgcgac gccagctcgg tctcgcccag ctgcgtgccc
     2761 ggcggcagcg cgccgttcat gatcgcgtcg cggagctgcc gcgcgatgat gcccgcggtg
     2821 gactcccggt tcaccggttc gatgtcggcc agcggcatgt cagtttccct tttcccggac
     2881 cgttctcgtg aacagagctc ccagctcgcc ggacgtcacc gagacgccgg cctgccggag
     2941 accttcccag atggtcacct ggttcgcggt gagaaccggc tttccgagcc ggttttcgat
     3001 ggcgccgagc acaccgagcg tgcgcatcgc ggtgtcgggc accagcacgg cgtcggcctc
     3061 cggatggtcg tgcgacaccg ccagctcgat caccgcctcc gggctcagct cgccgacctc
     3121 ggccgcggtg tcgatgtccg cactggacat ggtgagcacc tcgaccccgc cggcggcgag
     3181 gaactcgacg aacagccgtg ccacgtcgtc ggggtagctg gccgcgaccg ccaccttccg
     3241 cacgccgagc gccttggccg cttcgacgaa cgcgaaggaa gtgctggtcg acggtacgcc
     3301 ggcggcctcg gcgagctggt cggcctgctt gcgcgcgccc tcccagccgt agacgaagct
     3361 gccgctcgtg cacgcccaga tcaccgcgtc cggctcgtgc ttggcgagca gtccggcgcc
     3421 ttccttcaga cgctccgggc tgccgaggtc cagcagttcg ggcacggcgt gcaggtccgt
     3481 gccgtagatg tgctcgaccg ggagccggaa ctccggcccg aggaggtgtt cggccagcgg
     3541 gtagtcgtcc tcggccgcgt ggtccgggta gatgaagccg atcgtggtca agcctgagca
     3601 cctcctgcag attgtcaaca atcctaacga accacgctac gaaacgtcac gcaaccactt
     3661 gcccggaccg accagcggca ggcccatccg catcaggcag gcccacatgg tgagctggtt
     3721 cgcggtcagc accggcttgc cgagcgccgc ctccagcggc tcgatcaggt cgaaggtggg
     3781 caggttcgtg cagctgacaa aaaccgcttc ggcctcggag tggtcggcgg cgaggatgcg
     3841 ctcggcgatg gtccggtagc tcaccttcca gatgccgccg ccgagcccga ggtggtcact
     3901 ggacaccgtt ttcacgtcca gttcggtcag gaagtcgtgc agcttcccgg tcaggtcctg
     3961 gtcgtacggc gtcagcaccg agatcttgtg caggtcgagg cggtgcagca cctccgcgag
     4021 cgcgccggag gtggtcaccg cgtccggcgc gccggcgtcg cagatcgcct tgcacaacga
     4081 gcgctcgtag tcgatgccgt tgacgaagct gcccgacgtg cagaggtacg cgacaacctc
     4141 tggttccacg tgaagcacgt cacgcgtggc ggccgcgagg tgcttgctgt cactgaccag
     4201 ttgagccatc tccatgctca ccggcaccgg ctcgtagggc gtgcgtgcca ggtggaggga
     4261 cacctccatc ggcacccagc gccacaactc gcgctcgagc gcgaggtcga acggggcgat
     4321 caccccgatg ccccgctggg cgagcgggcc gtcgaacaca ggcatctgga aatccaaggc
     4381 caagcctccg cggtgacgtc ttcaggaatg cagagagcct ccggggtggc tcctcggatt
     4441 gttgacaatc atacgaccgg ctcataccgt gtcaacggtg atcggcacgg aatccccggt
     4501 gttggcggtg ctgtgcggcg accagcaccc cccggacatg gacagcatcg agcacgtggc
     4561 cgcggtgcgt tacaccgacg aggcgggttt aaagaaggcg ttacacggcg ctgacatcct
     4621 cttcgtctac gacttcctgt ccaccgccgt ccccggcgcg tgggaggccg cggacaagct
     4681 gcgctggctg cacatcgcga gcgccggtgt cgacccggtg ctgttccccg ggctgcgcga
     4741 gagcgacgtg gtgctgacga actcgcgcgg tgtcttcgac gacgccatcg ccgagtacgt
     4801 gctgggcgtg gtgctcgcct tcgccaagga cttcgcgcgc tcgcggcagt tgcagcagga
     4861 gcggacctgg ctgcaccgcg agaccgagcg ggtctccggc cgccgggcgc tggtggtcgg
     4921 caccgggccg atcggccggt cgatcgcccg cctgctgcgc gccgccgggc tgtccgtcgc
     4981 cggtgccggg cgcaccgcgc gcgagtccga tcccgacttc ggcgtggtgc acgcctccgc
     5041 cgagctgacc acgcacctcg gcgactacga ctacgtgatc gccgtcgcgc cgctgaccga
     5101 gcagaccaag ggcatgttcg acgcgcgcgc cttcgccgcg atgaagccag gcgcgcggtt
     5161 cgtcaacgtc ggccgggggg agctggtggt gaccggtgac ctgatcgccg cgttgcgcga
     5221 cggccgcccg gccggtgccg cgctggacgt gttcgacacc gagccgctgc cctcggatag
     5281 tccactgtgg acgatggaga acgtgctgat ctcaccgcac atgtccggcg acttcatcgg
     5341 ctggcgcaac acgctggtcg aggtgttcgc cgggaacttc gagcggtggc gcacggggca
     5401 gccgcttcgt aatgtcgtgg acaagggctt gggctacgtg ccgtcgggca gcaactgagg
     5461 aggaccatga acgagtcggg gaccctgctg acggccagtg agctcgtcgc ggcctacggg
     5521 tccggggagc tgtcgccggt ggaggcgacg caagcttcgc tcgacgcgat cgccgagcgg
     5581 gacggcgagc tgaacgccta ctgcctcgtc gacgccgact ccgcgctgga acaggcgaag
     5641 ctggccgagc agcggtggcg cgagggccat ccgatcggct ggctggacgg ggtgccgacc
     5701 tcgatcaagg acatgttcct cagccagggc tggccgacgc agcggggttc gcgctgcatc
     5761 gacccggccg gaccgtggga ggtcgacagc ccggtcaccg cgcggctgcg cgagcacggg
     5821 ctggtgctgc tcggcaagac gaccacgccg gagctgggct ggaaggccgt caccgacaac
     5881 acgttgaacg gcatcacccg caacccgtgg aaccccgcgc tgaccgcggg cggttcgagc
     5941 ggtggcagcg cggcggccgt ggcggcgggc atgggggagc tgtcggtcgg taccgatggt
     6001 ggtggctcgg tgcggattcc ggcttcgttc tgcggaatcg tcgggttcaa gccgacgcac
     6061 gggcggatcc cgctgttccc ggcgagcccg ttcggtccgc tggggcacgc cggtccgatg
     6121 gcgcgttcgg tggatgacgt ggcgttgctg ctcgacgtgc tcgccctgcc cgaccaccgc
     6181 gacccgtccg cgctggcgcc gcccgcgagt tcgtaccggg aggccgtgcg gcgggatgtg
     6241 cgcggggtga acgcggctta ttcggcgaat ctgggttatg tggacgtcga tccggagatc
     6301 gcgcggatca cgctggccgt ggtggccgcg ctgaacgagg cggggctgcg gatcgaggag
     6361 acggatcccg ggttcgcgga tccgctggat gcttttgatg tgctgtggtc gacgggcgcg
     6421 gcgaagtggc tggacacgtt cccggcgggt tcggaggagc tgatcgacca gggcctgcgg
     6481 cgggtttggg agcacgggca caccttctcg gcgagtgact acctcgaggc gagcgcggtg
     6541 cgggcggctt tgggcattca catgggcgag ttccacttgc ggcacgatgt gctgatcacg
     6601 ccgatgatgc cgatttcgcc ttttgaggct gggcacgatg tgccgccggg aagctcttat
     6661 cagacttggc cggagtggac gcggttcact tatccgttca acctgacgca gcagccggcg
     6721 atcagcgtgc cgatcggctt cacggcggcg gggttgccgg tggggttgca gatcgtgggg
     6781 ccgcggcact cggatgatct ggtgctggcg gtggcgaagc tggtggaaga ggtgaagccg
     6841 tgggctacgg accggcccgc ggctccgcgg cggtgactta ggcggggttg ggtcggcttg
     6901 gcctggcttg gcttgcgaga gcggtgctca ctttggtgag cgccgctctt gtttgtgcgg
     6961 ggtggcgggg gtggcatttg gtgtgcactg agtgcgggct tgggcttggt gagcgctgtc
     7021 ccgaaatgag agcagtgatc gcaagggaga gcactgctct tctttgtctg cgcgaggcga
     7081 cgcgccggtt ggcgggcgca gggtcggcgg gcgcgagggt tggcgggcgc gccggttgaa
     7141 gggcgcgagg gttggcgggc gcgagggctg gagggcgtgc ggggttggag agcgcgccgg
     7201 tcggagggcg cgagggctgg agggcgtgcg gggttggaga gcgcgccggt tgaagggcgc
     7261 gagggttggc gtgtcgggct ggcggtgcgc cgggcgcgtg tcagctacgg agcgggtgag
     7321 cggtccgcgg gagggacggc accggtgacg tcgctggggg tggcggattt ccgggtaagg
     7381 ccccgaatct ggcggctgca caatgcgaga gcggtgctca caagaacgag cagtgctccg
     7441 gcgagcagtg tggtgtccgc gccgaagcgc tccgccagcg gacccgcggc gatttcgccg
     7501 acgggcatgg cgatgaaaga gcccagcatg tcgtacgagt agacccgcgc cagtttgtcc
     7561 tccgggatgt tctcctgcaa agagacatcc caagccacca cgaactgctc gatagcgatc
     7621 cccgccagga acatcgtcgc cagcaacggg accaaagaag gcgcctccgc cagcgtcacc
     7681 aacggaaccg cctcgaccgc gatcaccgcg accccgatca acaacgcgtg ccgcggctgc
     7741 caccgcgcgg ccagcacccc gccgatgaac gcccccagcg tttccgccgc caggatgaat
     7801 ccccacgcgg cacgtccgac cgtgtcgtcc gcgaccttcg ggccgatcac cgcgtggctc
     7861 cccatgatca ccgcgttcac cacggtgaac tgcgcgacca cgatccacac ccacgaccgt
     7921 gcggtgaact cccgccatcc ttcgaccagg tccttcagcg gatgcgaacg ttcggcccgc
     7981 acccgcgcgg cgatccgcac cccgcgataa cccgccgcgg acagcaggaa gatgcccgcg
     8041 tccaccgcga tggcccagcc cgccccgacc cccgcggcga gcatcccgcc caaagccgcg
     8101 ccgaggattc ggccggtgtt cgcgcccatg cgggccagcg cgttcgccgg cgtgagcagg
     8161 gtcgcgggca ccgtctgcgg ggtcagcgaa gccgccgcgg gcagggacat cgcggcgacc
     8221 ccgccgttga gcgcgctcag cgccaacagc agtgggatcg aagcgaagcc gccgatcacg
     8281 ctggccgcga tcaggccctg ggtgagcgcc gcggccaggc cggtgccctg caggatcagc
     8341 gcacgcggca gccggtcggc gagcacaccg ccgaacagca gcaggatcac gttggccagc
     8401 gagcgcaccc cgaccaccag cccgaggtcg accaccgagc cggtcaggtc gagcaccgcg
     8461 aacgccagcg ccaccggcgc gatcgcgttg gccagttcgg cgccggtccg cccggccagc
     8521 agccaccgga aactgcggtg ctgcaagggt tcccgcaagc tcatggccgc accatctcga
     8581 acagggcgat ggtggcgctg actcgccggg tctccggcgt gcgcggcggt tgtgcctcgc
     8641 tgtgcagcag gtcgccgagt tcgttcgcca gctccaccgc gcgttcccag tcggcggggc
     8701 tgagccagac ctcggcgtcg gtgacggcgg accgtccgga cggctcgcgg tccacggtgc
     8761 ggcggcgcag ctcaccggcc agcgtctcgg cgaacagctg ctcaccctcg tgatcttcgt
     8821 ggttccaccg gggagcgttg ccggggacgt gccggtagcg cttcgccagc ccgccgtgga
     8881 tgcggacctc ctcggcgact tcgagcagcc ctgcctcatg cagccgccgc aggtggtagc
     8941 tcacgttggc ctgcgtgtcc tgaagctcgc gggcagcctc ggcggcgctc atcgcggccc
     9001 cggtgagcag tgacaggatg cgcaggcgca gcggatgggc gagcacgcgc agctcgacca
     9061 gtgaggtctt ctccggcatg gacccgagta tcagggcacc ggccgccgac tgtcaaacaa
     9121 atctttgggg gttgctgtgg ctatagggtc agcagcgtgc cgtccagggg gagttccgcg
     9181 cccgcggcca gtacttcctt gtgctccggg gaatccgggg cgagcgcggg attggtgttg
     9241 ttgaggtggg tgtaggccca gcgcggtccc ggcaggtcgc ggatccgggc gaggctgccg
     9301 tccgcaccgg agatcggtac gtgccccatg gcacgctgcg cctgcgagcc gaccccggcg
     9361 cgggtcgccc cggacatctc gtcggcgccg tagaaggtgc cgtccagcag cacgtagtcc
     9421 gcgccatcgg tgaactcgcc gaatcccggc ggccaggtcg ccaggcaggg cgcgtagacg
     9481 aacacaccgc cggtggacgg gtcctcgatc cggtaggcga ccacccatgg accgtccgaa
     9541 gtggagtcac gggcgtactt cggcttcttg tcgctgaccg gcagcgcgcg cacgcgaagg
     9601 ccgccgatct ccggctccac cggggagaag gtccagtccc cgtaccggcc gaccggcagg
     9661 gctccgcgca tcgcgtgcag ggcggcgtcc gggccccaga caccaaaaga aggcgcctcc
     9721 cgcaacatga ccaggccgag cgtgtggtcc agttcggcat cggtgaccag cgcgccgcgc
     9781 aacggcgtct cccgtggccc cggcccggcg cgcaacaccg gcgacgccag gatctgcgca
     9841 cggatgtccg gtgacgcgtt gagcaggtac cagccgcggc cgtcggcgct gatcgccacg
     9901 cagtcctgcg tccggggtgg agcgtccgaa gtgcacagtg cgcaggcgca gttccactgc
     9961 gggaaaccac ctccggcggc cgtcccgagc agcagcacct tcatcgcgcc acccgccgca
    10021 tgaccagctc cggttctacc gcgggcggtg gagcgctcag gatcaggtcg acgatctcgc
    10081 ggtccggcga gcgcgagcag accggatcgg tggcggccgc gtccccggtc agcaggaacg
    10141 cctggcagcg gcagccgccg tggtcggtgc cgcgccggtc acaggaccgg caggtctcgc
    10201 tcatccagtc ctcaccgcgg taggcgttga acgaggtcga gccgtaccag atgtcgtgca
    10261 acggcttccg ggtcacgttg tccagttcga gcgtgctgat cgcggtcgcc gccgggcacg
    10321 gcagcacgtc accgttcggg gccacggtca gctgccgtgc gccccagccg tacatgcacg
    10381 gcttcggata gggctcgtag tagtcggcga ccacgtagat gatctccatc gtgccgagca
    10441 ggcgctcggt ggcggcacgc acgatcggct cggcggcggc cagttgctcc ctggtcggca
    10501 tcagcgccgt gcggttcttc agcgcccagc cgtagtactg cgtgttcgcc agttcgagcc
    10561 ggtcggcgcc catgcgctcg gcgagcgcga tgaggccggc gagctggtcg tggttctgct
    10621 tgtgcagcac cacgttcacg ctcagcggca agccggattc cttgatcagc gcggccgtgg
    10681 cgatcttgtg gtcgtgggct ctggtgccgg cgagccggtc cgcgcgctcg gcgtccgcgc
    10741 cctgcaccga cagctggatg tgcgcgagcc cgcgctcggc caggtcgtcg agtcgcttgc
    10801 cggtcaggcc gaggccgctg gtcaccaggt tgacgtaaca gccgaggtcg ctcgcgtgtg
    10861 agaccagttc cggcaggtcc ggtctggcca gcggctcacc accggacatg tgcacctgga
    10921 gcacgccgag ttcgcgcgcc tgcgacagca cggaaagcca ctgctcggta ccgagttcgc
    10981 cgtccctggt gatcagctcg agcgggttgg agcagtacgg gcagtgcagc gggcagcggt
    11041 gggtcagctc ggccagcaaa cccagcggtg gctcggcggg cttcacgtcc attcgacgac
    11101 ccgccgttcc gccagccggg acagcactcc gttcacgtcc gcctcccgga ccccgcggta
    11161 ctgcttgccg agcgccgcgg tgatgtcggc gacgctggta tgcccgtcgc agagttcgag
    11221 cacggcggcg gcggttttgt tcggcaccag cacaccttcc gggtacagca gcacgtgcgt
    11281 ttcgcgcacc ttgtcgtagg tgagccggac accgcggcgc agtcggggga tcacgctcac
    11341 tccttggccg cggcgcgctc gatggcgtcc aaaatggacc acagcacgtc gcacttgaag
    11401 gagagcgcgg cgatcgcggc gtcctgctgc tccctcgtca cgcagtgccg cagcacgagg
    11461 tccacagtgg cctgtccctc tccggagacc gcgtcgatgc ggttggtgaa gtaggccagg
    11521 tcggcgcggt tgatccagtc gtagttcgcc agcatgtcgg ccacgcggcg tttcatcaga
    11581 tgaccggaga acatctcggt gagcccagag gcgaccgctt cgacccacgg ttttgtcctg
    11641 gcgaaggtga cataggcatc cacggcgaac cggacccccg gcgcgacgtg ccgctcgtcg
    11701 agtacctcct cgcggctgag gccgaccgcc tcgcacaacc gcagccagcg ctcgatcccg
    11761 ccctcgcccg gcgcggcgcc gtcgtggtag acgagccggg ggagccactg ccgccgcacc
    11821 tcgggcagcg ggcagttgct gatgatcgcg gcgtccttct gggggatcat gcgctggtag
    11881 taccagcggt tcgcggccca gatccgcagt tcgcgttcgg acagttcacc ggcgtgcatc
    11941 cggtggtgga acgggtgtgt gccccagtag cggtgggaca gtccacgcag ggcggcggcg
    12001 aactcctcgt ggctgagcgg cgcgctcatg gcggaccctc ctggtcgtcg aggcgcaggc
    12061 gggaggagcg gggaccgcgc gggcccccgc ccgcccgtgt tattccatcc gggccgcgta
    12121 ggccgtgact tccatcgggg tctcgtactc gacgaagtcc ggagtggtcc agacctcggt
    12181 agcggtttcg atcatgctga ctcctcggat cactgacgac cgggcaagac gaccctagaa
    12241 gcgccgccgg accgaaatct agggaagccg gctaatttct gacttgctcc aagccatcgt
    12301 cccgctgatg gagtagtaaa gccgcgctgg tgtcacccag ggtgagaaga atgatccgat
    12361 gactcaggcg accgcgctct ccagttcggc cagcgcggtg tccaggtggg tgaggatgcg
    12421 ctgcaggtgc ggcacgctgc ggcggcagcc ggtgatgccg aagtccaggt tgtcgccgtt
    12481 gctggtcagg gtgatgttca gcgcctgccc gtcgagcagc accgaggccg ggtagacacc
    12541 gtcgagctgc gcgccgttcc agtacatcgt cttgcggggc cccggcacgt tcgagatgac
    12601 caggttgaac ggcgggcgcg tgttgttgac gaatcccggg atggtggacg cgcccagcgg
    12661 ggccacgttg atgccggaca ggatcagcgc ctgcaacggc gtcaggtcgg agaagatccg
    12721 cttgccgtcc cgcatggact ggtggatcag cttgagccgc tcggccgggt cgctgcggtc
    12781 ggtggccagg ttgcacagca gcgcgccgac cgcgttgccg ccggcctcgc cggtttcggc
    12841 ccgcttgcgc atggacaccg gcaccatcgc caccatcgcg gtgtccggca gtgcccgctg
    12901 ctcgatcagg tagtcgcgca gggcgccgga gcacatcgcc agcaccacgt cgttgcgcga
    12961 gacgccggcc gcggtggcca cccggcgcac gcggtcgagc gaccaggact gcgcggcgaa
    13021 ccgccgcgcg ccgccgatcg gcacgttgag catggtcttc ggtgcctggg tgggcagggt
    13081 caggctgtgc tcgcggaagg cttcgcccgc caccttcacc gcggcccgcg gcagcttcgc
    13141 cagctgggcg agcgactgcc gcgtgccggt gagcagcgag accgggtcgc gccggttgcg
    13201 ccgcacgccc tgcgtcttcg gtccgctcca cggcggcggc gagtcgcgct cgtccgggct
    13261 gtcgctcagc gtcgactgca tctggcggag tgcggagacc ccgtccatca atgcgtggtg
    13321 caccttgctg tacatcgcga accggtcgtc ccgcaggccc tccaccaggt ggacttccca
    13381 cagtggacgg tgccggtcga gcaacgtgct gtgccagcgg ccggtcaact cgagcagttc
    13441 gcggatgcgg cccggctgtg gcagtgcgga atgccggaag tggtagtcca gttcgagttc
    13501 gacgtcctcg gcccaggcgg cgtaacccat ggtgttcacc ggacgggccg ggcggcggcg
    13561 gaaggcgcgg ctgacctcgg accgctcgag cagcctgcgc cggatttcgc tgaggtagtt
    13621 cggtccggcg tcctcgggtt tgcggaacag ctggaggccg ccgacgtgca tcggatgctc
    13681 ccgcgactcc acaaggagga acatcgagtc ggtaacgggc atcagcggca tatccggccc
    13741 ccttcgtcga gcagcggtga tcctgggttc caccggaggg ctgagtctac gcacggttca
    13801 gcaagaggaa agccctgaac aaacgattac cctgcgatca tggcgaacct gcccgaacgg
    13861 gccggcgtgg tgatcgtagg cggtggcgtg atcggcgtga gctgcgcgtt ccaactggcc
    13921 gaggccgggg tggacgtgct gctgctggag cggggcgcgc tgggcgccgg ctcgacggcg
    13981 aaggcggcgg gcggggtgcg ctcctcgttc accagccggg tcaacatcga actgggcttg
    14041 cgcgggctcg ccgagttcga gcggttcccg gcgcggttcg ggcaggagat cgacttccgc
    14101 cgcgacggtt acctctacct gatcaccgat cccgccgacc tgccgcggtt cgagcgcggg
    14161 gtggcgctgc agaactccct cggtgtggcg agccgggtga tcgaaccggc cgaggccgtc
    14221 cggcacaacc cgctgatctc ggtcgacggt gtgcacgccg cggtctggtc gcccgaagac
    14281 gggcgtgcca ctccggacgc ggtggtgcag gggtacgcgc gggccgcccg cgcactgggc
    14341 gcgaccttgt gcaccggcgt ggaagtggtg ggcatcgacc gtggcgacga gcagatccgc
    14401 gcggtccaga cctccagggg agtggtccgg accgaggtgg tgctgtgcgc ggccggggcc
    14461 tggtcggcgc gcatcggtga gctggcggga tgtccgctgc cggtcagccc ggagcggcgt
    14521 caggtggtgt tcaccggctc gataccggga cgaccggaat cggtaccgct gaccgtggaa
    14581 atgccgtcgg cgttctacct ccaccccgag ggcgacggct tggcgctgtc cctgccgggc
    14641 ggtccgggcg acgcggggtt cgactcgcgg tacgaaccgg gggagtggtt gcccgcgctg
    14701 gccgaagccg cgatgcgacg ggcgccgtcg gtgctcgacg cgggcatccg cacggcgtgg
    14761 gcggggctgt acgagatgac gccggatcgg aaccaggtgg tcggcgaggc ggccggggtg
    14821 tcgcggttcc tctacgccac cgggttttcc gggcacgggt tccagatggg cccggcggtc
    14881 ggcgcggtga tgcgggacct ctacctgggc cgggagccgg agatcgacgt ctcctcgctg
    14941 gacgtgcgcc ggttcgacgg cggcgtgacg acgagggcgg agtacaacat cgtctaggcg
    15001 gggtgttcaa tcgttgaacg atctcgtagg ctgtgccggt gccggtagtc agccatgcca
    15061 agccgaagtc cggggccgat cagctcgccg acgcactggg tgaactgggt gtgggggtcg
    15121 ccttcggctt accgggggtg cacaacctgc cgatctggga agccctcgcg gacaccggga
    15181 tccagttgct cggcgtccgc cacgaacaga ccgccgcgta cgccgccgac ggatacgccc
    15241 gtgccaccgg gaagctcggc gtcgcgatcg tgaccaccgg gcccggtgcg gcgaacacgc
    15301 tcgccgcggt cggcgaagcg caggcctccg gctctccggt gctggtcatc gccaccgaca
    15361 tcccttcgac gctccggcgt cccggcacgg tgcgcggggt gctgcacgag accagcgacc
    15421 aggcggcgat gttcgcgccg ctgaccaagg gccagtacac cgtcggcgga ccggaagaga
    15481 tcgccggcgc cacgctcgcg gcggcgcggc tggcgctgcg accgcagagc ggcccggtct
    15541 acctgggcat tccgaccgac ttcctgtccg ccgccgccaa gcgcgcgccc gatccggccg
    15601 atctcacgcc ggtgcccgaa ccgctcgacc tcgggcgcgc gcgggagttg ttcgagcgcg
    15661 ccgagcggcc gctgatctgg gccggtggcg gcgcgctgcg ggccggggcg ggcgcggtca
    15721 tcggtgagct ggcggagaag ctggcggcgc cggtgctcac caccttcgcc gcgcgtggcc
    15781 tgctcccgcc cgaacaccct tgcctggccc cgaactcggt gcacacgccg gaggtcggcg
    15841 cgctctggga cgaagccgat ctggtgctcg gcgtcggcac cgacttcgac gggctgatga
    15901 cgcagaactg gctgatgccg cagccgccga cgctggtcac ggtgaatatc gacgcggcgg
    15961 acgcggcgaa gaactaccag ccggacctga acctggtcgg cgatgcccgc gcggtggtca
    16021 ccgcgttgct cggcgaactg cctgccaagg acggcctgga gaagctcacc gcgcggctgc
    16081 gccggatgag cgcggccgtg cgccgccgca tccgcgagga cgagccgcag gccgccgact
    16141 tcctcggcac gctggaggaa gtgctgcccg aggacgcgat cctggtctcg gacatgtgca
    16201 tcgcgggtta ctggatcggt ggtttccacc gcatcccggg gccgcgcaag ctcgcctacc
    16261 cgatgggctg gggcacgctc ggcttcggtt ttcccgcctc gatcggcagt gcggcggccg
    16321 gtgccgggcg cgcggtctgc gtcaccggtg acggcggttt cctctacggc gtaggggatc
    16381 tggctaccgc cgcgcaggag gacctgcggg tcaccgtggt cgtggtggag gacggcgggt
    16441 acggcatgct ccggttcgac caggagcaca gcggcctgcc gcaccgcggg gtcgatctgg
    16501 tcgggccgga cttcgtcgcg atggccaagt cgttcggcgt gcgctccgaa cgggtcaagg
    16561 gcttcggccg cgccttccgg cggaagctga gcgcgttcat ccaggccgac gaaccgaacg
    16621 tgctggtggt cgaagccgcc atgcgcccac cgctcaacac ctcgccccgc tggtaccgga
    16681 aggagcggtg atgacgctgc gcgtcggtgt cgacatcggt ggcacgttca ccgatctgtg
    16741 cgtgctcgac gattccgggg tggtggccat cggcaaggcg ctgaccaccc acgacgagcc
    16801 cgcccgcgcg gtcggcgaac tgctgcggga cgtcgtcccc gatccgtccc aagtggacaa
    16861 gctggtgcac ggcacgacgc tggtcaccaa cgcgctgatc gagcgcaagg gctcgaagct
    16921 ggcgctgctg gccaccgcgg gcttccgcga cgtgctggaa atgcgccgtg aacaccgcta
    16981 cgagctgtac gacctccaga tcgagttgcc ggaaccgctg gtgccgaggc atctccggtt
    17041 cgacgtaccg gagcgcatcc tcgccgacgg cagtgtgcag accccgctcg acgaggagta
    17101 cgtcgcccgg ctcggcacgg agctggccga gcgcgggatc gaggcggtgg ccgtctgctt
    17161 cctgcactcc ttcaccaatc ccgagcacga acgccgcgtg cgggccgtgc tggcggaggt
    17221 cgccccgggg ctgcgcgtcg cgttgtcctc ggaggtggtg ccggagatcc gcgagttcga
    17281 gcgggcctcg accaccgccg cgaacgtgta cgtgcaggac ctgaccgagc gatacctgcg
    17341 tgacctggaa cagcgcgtgc accgcgccgg aatcggcccg gcaccgcaca tcatgctgtc
    17401 caacggcgga atagccacag tggacaccgc ggcccgctat cccatccgca tcctcgaatc
    17461 cggcccggcc ggtggcgcgc tggcggcgtc ggcgttcggc gcggcggccg gtgaggccga
    17521 tctgctcgcc ttcgacatgg gtggcaccac ggcgaagttg tgcatgatct ccgacggcgc
    17581 gccgctggtc acgcacgagt tcgaagtgga cagggtgtac cggctgctgc ccgggtccgg
    17641 attgccggtg aaggtgccgg tgaccgacat gatcgagatc ggcgtcggcg gtggctcgat
    17701 cgcccgcatc gacgcgctcg gcctgctcac cgtcggcccc gattcggcgg ggtccgagcc
    17761 ggggccggtg tgttacggcc gcggcggcac cgaacccacg gtcaccgacg ccgacctggt
    17821 gctcggttat ctcgatcccg ggtatttcct gggcggcgaa atggcgctgg acctggacgc
    17881 cgcgcgcgag gtgatccagc ggcggatcgc cgaaccgctg ggcgtcggac tggccgaggc
    17941 ggcgtacggc atccacgcgc acgtcaacga ggacatggcc aacgcggcgc gggtgcacgc
    18001 ggtggaacgc ggcaaggacc cggcgcggct gccgatgttc accttcggcg gcgccggtcc
    18061 ggtgcacggg gtgggcgtgg cgcgggcgct gggtgcccgg caggtggtcg ccccaccggc
    18121 cgccggggtg atgagcgcgg tcggtttcct caccgcacca ctggctttcg acttcgtgcg
    18181 cacgtcgcga gccggggtcg acgagctgag ctggtccgaa gtggacgcgc tgttcgccga
    18241 gatggaacgt gagggcgagg aactgctgaa ggcgtccggt gtggacaccg tgacgcacag
    18301 ccggatcgcc gaaatgcggt acgcggggca gggctacgaa atccgcgtgc cggtgaacca
    18361 gggcgaatgg cccgccacct tggtgaacga cttcaccgag gcgtaccgcg agctgtaccg
    18421 ccggaccggg ccggacgtcg gcgtcgaggt gctcaactgg cgggtggtct cgtcgggccc
    18481 ggtgccccgg gtgaacctcc ggctcagcgt ggaagccggg acaggagaag cacgcaaggg
    18541 cagcaggcag gcctacttcc cgggtggttt tgtcgacacc gcggtgtacg accggtaccg
    18601 gctgcgtgcg gacgaccgca tcgacggccc ggcgatcatc gaggaacgag agtccacttt
    18661 ggtcattccg ccggacgcga gctgcaccgt gcgggccgac tccagtctgg tggtgacccc
    18721 gtgatcgtgg acccgatcct ggtcggcgtg gtcggcaacc ggctgcactc gatcctggcc
    18781 gaacagcaga acgcactggt caacacggcg ttctcgtcgg tggtgcgtga atcgctcgac
    18841 ctggcgtgcg cggtcttcga ctcgcgtggc gagatgatcg ggcagtcggt cggcggcact
    18901 cccggccaca tcaacgcgat ggccaccggg atgcaccact tcgtcgccgc cttcccgccg
    18961 gaacagctgg cgccgggtga cgtgctgctg accaacgacc cgtggcagac ggcgggccag
    19021 atcaacgaca tcaccgtggc caccccggtt ttccaccgcg gtcgagtgat cgcgtggttc
    19081 gcttcgtgct gccacgcccc ggacatcggc ggccgcctgg tttcggccga ggccaacgag
    19141 gtgttcgaag agggcctccg gctgccgatc atgaagttcc tccgcgccgg tgaggtgaac
    19201 gccgagctgg aggcgatcat ccgcgcgaac gtgcgcacgc cggaggaaac catcggcgac
    19261 ctgtacgcgc aggtggcggg caacgacgtc ggggcggcga gcctggtgcg cctggccgag
    19321 gagttcggcc tggactcgat cgacgagatc gccgcggaga tcatgaaccg ctcggaacgg
    19381 gcattgcgcg acgccatcgc cgcgttgccc gacggcacct tccgcagcga gttgcgcacc
    19441 gacggcttcg gtgaggaaga agtgttactg aaggtcgcgc tgaccgtgcg cggtgaggac
    19501 atcgacatcg acttcgccgg ttcgtcgccg cagagcaagc acggcatcaa cgtggtcctc
    19561 aactacacca gggcgtacgc ctcgttcgcg gtgaaggcgg cgatcgcccc cggcgtgccg
    19621 cacaacgcgg gttcgttccg gccggtgcac gtgaccgcgc ccgccggatc ggtgctcaac
    19681 tgcctgccgc ccgcgccggt cgcctcccgg cacctgatcg gccacttcct gccgtcgctg
    19741 ctgatcggcg cgctggacgg gcggatggcg cacagcgcgg acgcgctctg gatgaccatc
    19801 tggcgtggac agtcgcatga ggatggacgc gagttcatgc tgaacgtctt ccagaccggc
    19861 ggcatcgggg ccagagccac caaggacggg ctcaacacca ccgggttccc cagcggcctg
    19921 cgggccacgc cgaccgaggt gatcgagacc atggcaccac tggtccagac ccggcgggtg
    19981 ctgcgcaccg actccggcgg tgccggtacc caccgcggcg gcctcggcca gtcgaccacg
    20041 gtgaccgcgc gcggtgacat ttcctggagc gtcaacggga acgtcgaccg caccagctca
    20101 ccggcgatcg gtgtgcacgg cggactggac ggcgcacccg gccgattcgg cctggccgac
    20161 ggcaccgcgc tgccgggtaa gcgccgggtg acgctggagc cggacgcggt cgtcgacgtg
    20221 gtgcttcccg gcgcgggtgg ttacggcgat ccgcgcgaac gcgacccgga acgcgtgctc
    20281 gccgacgtgg tcgacgggta cgtctcgatc gaggccgccc gtgacgtcta cggcgtcgaa
    20341 atccgctaca ccggcaggcc ggacgcgctg gtccggctgc ccgccgacta ccagatcgtg
    20401 gagagggact gacatggggc gtgtggaaga caaggtcgtc gtggtgttcg gcggggcgcg
    20461 cgggatcggc ctggcctcgg tgaaggagtt cctcgccgag ggcgcgatcg tgcggtcgag
    20521 cgacatccgc gagcccgccg aggagatcgg gcaccagaac ttcacccaca ccaccgtcga
    20581 cgccaccgac gaggaagccg tccagtcctt tgtggagcag gtgctcggtg agcacggccg
    20641 gatcgacgtg ttgttcggca atgtcggcat ccacctcggc aagccgctgc cggagacgac
    20701 gctcgccgag ttcgaccaca tcttcgcgct gaacgtgcgc accgcgttcc tggccacccg
    20761 ggcggtgctg ccgcacatga tcgaggccaa ggccggcagc atcgtgctca cctcgtccaa
    20821 cggcggcatg atgggccgcc cggccgaccc ggtctacaac gccaccaagc acgcgctggt
    20881 cgggctggcg aagtcgctcg cggtggcgca cgcgcacctc gggatccgcg taaacacggt
    20941 caatcccggt gcgatcgaca ccgacatgct gcgcagcacg ctggcctcgc ccgacgactt
    21001 cgaagccaag cagcaccagc tgaccgcgag cacgcccgcc gcgcgcgtcg gtgaggcgtg
    21061 ggaggtggcg aaggcggtgc tgttcctggc cagcgacgaa tcgcggttca tcaacggcgc
    21121 ggtggtgccg gtcgacgggg cgaaggcggc cggggccatg ccgggcaacc gctactccct
    21181 cgacttcgaa ctgggcgtgc gatgaccagc ggcgatccgt cggcggtgct cgcgggggac
    21241 cggagcgccc tcgcccgtgc gggcaccgcc gagcgggtgg cccagatcct gcgccagcgc
    21301 atcgccgagg gcgttttcct gccggggacc cggttggccg aaccggcgat cagctcggcg
    21361 ctcggggttt cccgcaacac cctgcgcgag gcgttccagc tgctggcgca cgagcggctg
    21421 gccgtgcggg aactgaaccg gggggtgttc gtccgcgagc tgaccgggcc ggacatcgtg
    21481 gacctgtacc ggatccggcg catggtggag tgcgcggccg tgcgtgaggc cgccgaccgc
    21541 gacggcctgg tgctcaccgc actggtggac gcgctggccg agggcaagca ggccgcgcgc
    21601 gacgaggact ggcaggccgt cggcaccgcc agcatccgtt ggcaccaggc gctttccgag
    21661 ctgtccggca gcgaccgggt ggcgggcacc atgcgccagg tgctcgccga gacgcggttg
    21721 ttcttcgtgc tgaccgagaa cacgcaggcc ttcttcgagc cgtacctggc gcggcacgag
    21781 aagatcatcg gacacctccg gcgacgccgg ttcgacctcg ccgagcaggc actggaacgc
    21841 tacctccgag acgccgagcg ccagttgctc gccgcgtacc accgaaggga gaccccatga
    21901 ccgcaccccg gttcttcgat gccgacgaga tcggcgccgt gctcggggtc gacgcggcga
    21961 tcgagtcgca gcggcgcgcc ttccgcgcgc tcggcgcgaa aaccgccgtg ctgccggcca
    22021 aaacccatg
//
