GCF_009429125.1 - 5 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP045529.1 (Luteimicrobium xylanilyticum)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	furan	336,242	357,165
Region 2	terpene-precursor	2,307,972	2,329,075
Region 3	terpene	3,020,220	3,044,484	Low	carotenoid	terpene
Region 4	lassopeptide	3,111,424	3,133,724
Region 5	RiPP-like	4,063,149	4,074,000

NZ_CP045529.1 - Region 1 - furan

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Location: 336,242 - 357,165 nt. (total: 20,924 nt) Show pHMM detection rules used

furan: (mmyO or AvrD)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

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Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001485.4	0.36	other (other)	chuangxinmycin	Actinoplanes tsinanensis
BGC0002227.3	0.36	NRPS	AKML B, AKML D, AKML A, AKML C	Aspergillus luchuensis IFO 4308
BGC0000676.5	0.34	terpene	aphidicolin, aphidicolan-16β-ol, 3-deoxyaphidicolin, 17-deoxyaphidicolin	Phoma betae
BGC0000688.4	0.33	terpene	copalyl diphosphate	Diaporthe amygdali
BGC0002208.3	0.32	NRPS	oxepinamide F	Aspergillus ustus
BGC0001026.3	0.32	NRPS, PKS	NG-391	Metarhizium anisopliae
BGC0001778.5	0.32	other (other)	showdomycin	Streptomyces showdoensis
BGC0000277.5	0.32	PKS	urdamycin	Streptomyces fradiae
BGC0001954.2	0.32	NRPS, PKS	wortmanamide A, wortmanamide B	Talaromyces wortmannii
BGC0001122.4	0.31	NRPS, PKS	dihydroisoflavipucine, isoflavipucine	Aspergillus terreus NIH2624

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001485.4	0.36	other (other)	chuangxinmycin	Actinoplanes tsinanensis
BGC0002227.3	0.36	NRPS	AKML B, AKML D, AKML A, AKML C	Aspergillus luchuensis IFO 4308
BGC0000676.5	0.34	terpene	aphidicolin, aphidicolan-16β-ol, 3-deoxyaphidicolin, 17-deoxyaphidicolin	Phoma betae
BGC0000688.4	0.33	terpene	copalyl diphosphate	Diaporthe amygdali
BGC0002208.3	0.32	NRPS	oxepinamide F	Aspergillus ustus
BGC0001026.3	0.32	NRPS, PKS	NG-391	Metarhizium anisopliae
BGC0001778.5	0.32	other (other)	showdomycin	Streptomyces showdoensis
BGC0000277.5	0.32	PKS	urdamycin	Streptomyces fradiae
BGC0001954.2	0.32	NRPS, PKS	wortmanamide A, wortmanamide B	Talaromyces wortmannii
BGC0001122.4	0.31	NRPS, PKS	dihydroisoflavipucine, isoflavipucine	Aspergillus terreus NIH2624

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.16 out of 18.16

Confidence: strong

Additional weak hits (4):

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.47 out of 26.33

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 19.08 out of 28.19

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 16.90 out of 28.19

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 21.13 out of 36.53

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator

NZ_CP045529.1 - Region 2 - terpene-precursor

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Location: 2,307,972 - 2,329,075 nt. (total: 21,104 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

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Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: acyltransferase

KDY119_RS10335: acyltransferase

smcogs: SMCOG1141: acyltransferase

Ligases: synthetase

KDY119_RS10310: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000677.5	0.42	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0001911.3	0.38	terpene	raimonol	Streptomyces anulatus
BGC0002309.2	0.37	terpene	cattleyene	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0001456.3	0.37	terpene	isorenieratene	Streptomyces argillaceus
BGC0000936.5	0.37	other (other)	pyocyanine	Pseudomonas aeruginosa PAO1
BGC0001910.4	0.37	terpene	cyslabdan A, cyslabdan B, cyslabdan C	Streptomyces cyslabdanicus
BGC0000664.5	0.36	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001227.3	0.35	terpene	isorenieratene	Streptomyces collinus Tu 365
BGC0000633.3	0.35	terpene	carotenoid	Streptomyces avermitilis
BGC0001483.4	0.35	other (other)	5-isoprenylindole-3-carboxylate β-D-glycosyl ester	Streptomyces sp. RM-5-8

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000677.5	0.42	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0001911.3	0.38	terpene	raimonol	Streptomyces anulatus
BGC0002309.2	0.37	terpene	cattleyene	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0001456.3	0.37	terpene	isorenieratene	Streptomyces argillaceus
BGC0000936.5	0.37	other (other)	pyocyanine	Pseudomonas aeruginosa PAO1
BGC0001910.4	0.37	terpene	cyslabdan A, cyslabdan B, cyslabdan C	Streptomyces cyslabdanicus
BGC0000664.5	0.36	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001227.3	0.35	terpene	isorenieratene	Streptomyces collinus Tu 365
BGC0000633.3	0.35	terpene	carotenoid	Streptomyces avermitilis
BGC0001483.4	0.35	other (other)	5-isoprenylindole-3-carboxylate β-D-glycosyl ester	Streptomyces sp. RM-5-8

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor	FPP	C15	acyclic	PP
diterpene precursor	GGPP	C20	acyclic	PP
sesterterpene precursor	GFPP	C25	acyclic	PP
triterpene precursor	HPP	C30	acyclic	PP

Genes with terpene domains:

KDY119_RS10310: PT_FPPS_like

Domain 1 (50 - 344): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (5):

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.06 out of 26.33

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 22.61 out of 30.22

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 15.72 out of 29.38

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 18.61 out of 35.63

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 16.98 out of 28.19

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description

NZ_CP045529.1 - Region 3 - terpene

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Location: 3,020,220 - 3,044,484 nt. (total: 24,265 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

KDY119_RS13385: dehydrogenase

smcogs: SMCOG1222: dehydrogenase

Lyases: hydratase

KDY119_RS13425: Nitrilase/cyanide hydratase and apolipoprotein

smcogs: SMCOG1294: Nitrilase/cyanide hydratase and apolipoprotein

Ligases: synthetase

KDY119_RS13395: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000644.3	0.63	terpene	carotenoid	Dietzia sp. CQ4
BGC0000637.3	0.61	terpene	carotenoid	Corynebacterium glutamicum
BGC0000650.3	0.58	terpene	carotenoid	Algoriphagus sp. KK10202C
BGC0001456.3	0.54	terpene	isorenieratene	Streptomyces argillaceus
BGC0000636.3	0.50	terpene	carotenoid	Brevibacterium linens
BGC0000648.3	0.50	terpene	carotenoid	Myxococcus xanthus
BGC0000664.5	0.47	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000641.3	0.47	terpene	carotenoid	Enterobacteriaceae bacterium DC416
BGC0000633.3	0.47	terpene	carotenoid	Streptomyces avermitilis
BGC0001227.3	0.47	terpene	isorenieratene	Streptomyces collinus Tu 365

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000644.3	0.63	terpene	carotenoid	Dietzia sp. CQ4
BGC0000637.3	0.61	terpene	carotenoid	Corynebacterium glutamicum
BGC0000650.3	0.58	terpene	carotenoid	Algoriphagus sp. KK10202C
BGC0001456.3	0.54	terpene	isorenieratene	Streptomyces argillaceus
BGC0000636.3	0.50	terpene	carotenoid	Brevibacterium linens
BGC0000648.3	0.50	terpene	carotenoid	Myxococcus xanthus
BGC0000664.5	0.47	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000641.3	0.47	terpene	carotenoid	Enterobacteriaceae bacterium DC416
BGC0000633.3	0.47	terpene	carotenoid	Streptomyces avermitilis
BGC0001227.3	0.47	terpene	isorenieratene	Streptomyces collinus Tu 365

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
tetraterpene	C40 carotenoid		C40	unknown	unknown

Genes with terpene domains:

KDY119_RS13375: Lycopene_cycl

Domain 1 (10 - 96): Lycopene cyclase

Reactions:: C40_carotenoid → C40_carotenoid

KDY119_RS13380: Lycopene_cycl

Domain 1 (5 - 91): Lycopene cyclase

Reactions:: C40_carotenoid → C40_carotenoid

KDY119_RS13390: PT_phytoene_like

Domain 1 (17 - 289): Prenyltransferase; Phytoene synthase like

Subtype: unknown

Reactions:: FPP → squalene; FPP → diapophytoene; FPP → PSPP; GGPP → phytoene; PSPP → hydroxysqualene

KDY119_RS13395: PT_FPPS_like

Domain 1 (52 - 334): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

Transcription Factor Binding Sites

Binding sites found:

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.26 out of 19.26

Confidence: medium

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 20.67 out of 25.31

Confidence: medium

Additional weak hits (8):

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 18.70 out of 26.12

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.15 out of 30.22

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 17.99 out of 26.33

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 19.92 out of 30.98

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 14.79 out of 33.14

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 15.49 out of 33.14

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 16.52 out of 28.19

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 16.26 out of 28.19

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PSPP	Presqualene diphosphate

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
CatR	H2O2-responsive repressor

NZ_CP045529.1 - Region 4 - lassopeptide

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Location: 3,111,424 - 3,133,724 nt. (total: 22,301 nt) Show pHMM detection rules used

lassopeptide: (PF13471 and Asn_synthase or micJ25 or mcjC)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lasso peptides

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: acetyltransferase glycosyltransferase

KDY119_RS18915: Chloramphenicol acetyltransferase

smcogs: SMCOG1156: Chloramphenicol acetyltransferase

KDY119_RS19155: glycosyl transferase group 1

smcogs: SMCOG1045: glycosyl transferase group 1

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001552.3	0.53	ribosomal	citrulassin F	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0001549.3	0.52	ribosomal	citrulassin B	Streptomyces aurantiacus JA 4570
BGC0001634.3	0.52	ribosomal	keywimysin	Streptomyces sp. NRRL F-5702
BGC0000575.5	0.51	ribosomal	lariatin	Rhodococcus jostii
BGC0001551.4	0.50	ribosomal	citrulassin E	Streptomyces glaucescens
BGC0001889.2	0.50	ribosomal	fusilassin	Thermobifida fusca YX
BGC0002289.2	0.49	ribosomal	Leepeptin	Streptomyces leeuwenhoekii
BGC0000737.3	0.48	saccharide	capsular polysaccharide	Pasteurella multocida
BGC0001639.3	0.46	ribosomal	klebsidin	Klebsiella pneumoniae
BGC0002064.2	0.46	ribosomal	felipeptin A2, felipeptin A1	Amycolatopsis sp. YIM 10

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001552.3	0.53	ribosomal	citrulassin F	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0001549.3	0.52	ribosomal	citrulassin B	Streptomyces aurantiacus JA 4570
BGC0001634.3	0.52	ribosomal	keywimysin	Streptomyces sp. NRRL F-5702
BGC0000575.5	0.51	ribosomal	lariatin	Rhodococcus jostii
BGC0001551.4	0.50	ribosomal	citrulassin E	Streptomyces glaucescens
BGC0001889.2	0.50	ribosomal	fusilassin	Thermobifida fusca YX
BGC0002289.2	0.49	ribosomal	Leepeptin	Streptomyces leeuwenhoekii
BGC0000737.3	0.48	saccharide	capsular polysaccharide	Pasteurella multocida
BGC0001639.3	0.46	ribosomal	klebsidin	Klebsiella pneumoniae
BGC0002064.2	0.46	ribosomal	felipeptin A2, felipeptin A1	Amycolatopsis sp. YIM 10

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lasso peptide predictions

Lassopeptides - No core peptides found.

Lasso peptides

RREFinder

Core peptide predictions

No core peptides found.

RRE predictions

: RRE type: Stand_Alone_Lasso_RRE; Location: 4 - 83; Score: 66.5

NZ_CP045529.1 - Region 5 - RiPP-like

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Location: 4,063,149 - 4,074,000 nt. (total: 10,852 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000567.3	0.32	ribosomal	trifolitoxin	Rhizobium leguminosarum
BGC0001131.5	0.31	NRPS	ambactin	Xenorhabdus miraniensis
BGC0001692.5	0.26	NRPS	nematophin	Xenorhabdus nematophila ATCC 19061
BGC0001735.5	0.25	other (other)	pentostatine, vidarabine	Streptomyces antibioticus
BGC0000896.5	0.24	other (other)	cycloserine	Streptomyces lavendulae subsp. lavendulae
BGC0001882.3	0.22	PKS	chrysoxanthone A, chrysoxanthone B, chrysoxanthone C	Penicillium rubens Wisconsin 54-1255

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000567.3	0.32	ribosomal	trifolitoxin	Rhizobium leguminosarum
BGC0001131.5	0.31	NRPS	ambactin	Xenorhabdus miraniensis
BGC0001692.5	0.26	NRPS	nematophin	Xenorhabdus nematophila ATCC 19061
BGC0001735.5	0.25	other (other)	pentostatine, vidarabine	Streptomyces antibioticus
BGC0000896.5	0.24	other (other)	cycloserine	Streptomyces lavendulae subsp. lavendulae
BGC0001882.3	0.22	PKS	chrysoxanthone A, chrysoxanthone B, chrysoxanthone C	Penicillium rubens Wisconsin 54-1255

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.13 out of 19.26

Confidence: medium

TFBS Finder

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein