LOCUS       NZ_CP045178            22727 bp    DNA     linear   CON 25-NOV-2024
DEFINITION  Streptomyces tsukubensis strain AT3 chromosome, complete genome.
ACCESSION   NZ_CP045178
VERSION     NZ_CP045178.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces tsukubensis
  ORGANISM  Streptomyces tsukubensis
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8615214)
  AUTHORS   Cao,G., Zhong,C., Fu,J., Zhang,P., Liu,M. and Zong,G.
  TITLE     Complete genome sequence of Streptomyces tsukubaensis AT3
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8615214)
  AUTHORS   Cao,G., Zhong,C., Fu,J., Zhang,P., Liu,M. and Zong,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-OCT-2019) Shandong Medicinal Biotechnology Center,
            Shandong First Medical University, 18877 Jinshi Road, Jinan 250062,
            China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 01-OCT-2019
            Assembly Method :: SOAPdenovo v. OCT-2019; SPAdes v. OCT-2019
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 997.0x
            Sequencing Technology             :: Illumina HiSeq; PacBio RSII
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_009296025.1-RS_2024_11_20
            Annotation Date                   :: 11/20/2024 08:40:01
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,005
            CDSs (total)                      :: 6,919
            Genes (coding)                    :: 6,691
            CDSs (with protein)               :: 6,691
            Genes (RNA)                       :: 86
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 65
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 228
            CDSs (without protein)            :: 228
            Pseudo Genes (ambiguous residues) :: 0 of 228
            Pseudo Genes (frameshifted)       :: 76 of 228
            Pseudo Genes (incomplete)         :: 184 of 228
            Pseudo Genes (internal stop)      :: 10 of 228
            Pseudo Genes (multiple problems)  :: 38 of 228
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 05:10:03
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6740993
            Orig. end                         :: 6763720
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP045178.1.
            Bacteria and source DNA available from Dr. Guangxiang Cao.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22727
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /product="RiPP-like"
                     /region_number="27"
                     /rules="(micKC and not PKS_KS)"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..22727
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="neighbouring"
                     /product="lanthipeptide-class-iii"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    1..22727
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12727](-)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12727)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     misc_feature    complement(255..270)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.75"
                     /tool="antismash"
     misc_feature    complement(837..852)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.52"
                     /tool="antismash"
     gene            complement(866..2056)
                     /locus_tag="GBW32_RS28420"
                     /old_locus_tag="GBW32_28410"
     CDS             complement(866..2056)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003997032.1"
                     /locus_tag="GBW32_RS28420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_28410"
                     /product="DUF4349 domain-containing protein"
                     /protein_id="WP_227025324.1"
                     /transl_table=11
                     /translation="MRPAPVYGASGWGEPGTARVRGGPVAGRGARALAGMLLAGALAVA
                     GCSGGGASGDGDAGGDSRAGRPAAGDDGKGGAAGPGAERPGSAARESVGRADGRTAGRL
                     PDAAGTHLIRTASLRVRVKDVADALDAARAAARDAGGIVGDETTDRDGEGRESSRIVLR
                     VPRSSYDEVLAALAGTGTLVERKVKARDVSEQVVDVDSRVESQRASVARVRALMDDAKR
                     ISDVVALEGELSTREADLESLLARQASLKDRTSMATITLRLSQRAGTAPGGHEEESGFT
                     DALGGGWDVFVTIARGVALAVGAALPFLAAGAVTLVLWRLFRGRLPRRARPAAAGASPA
                     WHALAEPRGGATPEPVASAGPAEPAGPGGTGRTGADEAEPHPRGGDEGGEAPGRRT"
     gene            2247..3710
                     /gene="hemG"
                     /locus_tag="GBW32_RS28425"
                     /old_locus_tag="GBW32_28415"
     CDS             2247..3710
                     /EC_number="1.3.3.4"
                     /GO_function="GO:0004729 - oxygen-dependent
                     protoporphyrinogen oxidase activity [Evidence IEA]"
                     /GO_process="GO:0006779 - porphyrin-containing compound
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="hemG"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007445289.1"
                     /locus_tag="GBW32_RS28425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_28415"
                     /product="protoporphyrinogen oxidase"
                     /protein_id="WP_077967432.1"
                     /sec_met_domain="DAO (E-value: 1.5e-09, bitscore: 36.6,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MCAAVTETGQSRTGTPHVVVVGGGIAGLAAAHRALGAGARVTVLE
                     ASPRLGGKLHAGEIEGVRVDLGAESMLARRPEAVDLAREVGLGELLQPPGTATAALWTR
                     GELRPMPKGHVMGVPGDAAALAGVVSAEGLRRIAEDSELPATEVGEDIAVGRYVADRLG
                     REVVDRLVEPLLGGVYAGDAYRISMRAAVPQLFEVARTHRSLTEGVRDIQARAGKQQGA
                     VPVFMGIEGGIGRLPLAVADSVRARGGDILTGAAVTELRRTGAGQNGAGWRIVAGESVF
                     EADAVVIALPAPHAARLLAAESPAAAAELTAVEYASMALVTLAYRTEDAATLPSGSGFL
                     VPPVDGHTIKAATFSANKWGWSAAENRGLRVLRTSIGRYGDEDDLSRADDDLIRVARGD
                     LRAATGLDALPVAARVTRWDQGLPQYPVGHQARVARVRRYVGALPGLAVCGAAYDGVGI
                     PACVASAAAAVDLVVGRGPASSTADGARE"
     gene            3715..4440
                     /gene="hemQ"
                     /locus_tag="GBW32_RS28430"
                     /old_locus_tag="GBW32_28420"
     CDS             3715..4440
                     /EC_number="1.3.98.5"
                     /codon_start=1
                     /gene="hemQ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003951588.1"
                     /locus_tag="GBW32_RS28430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_28420"
                     /product="hydrogen peroxide-dependent heme synthase"
                     /protein_id="WP_077967433.1"
                     /transl_table=11
                     /translation="MSAAPEKPEKAQNAGKKAKDLNDVIRYTLWSVFKLRDALPEDRAG
                     YADEVRELFDQLAAKDVTVRGTYDVSGLRADADLMIWWHAETSDQLQEAYNLFRRTRLG
                     RSLEPVWSNMALHRPAEFNKSHVPAFLADETPRDYVSVYPFVRSYDWYLLPDEERRTML
                     ADHGKMARGFPDVRANTVASFSLGDYEWILAFEADELYRIVDLMRHLRGSKARLYVREE
                     VPFYTGRRRSVAELVAGLA"
     misc_feature    4573..4584
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: strong, score: 19.78"
                     /tool="antismash"
     misc_feature    complement(4722..4735)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 17.83"
                     /tool="antismash"
     gene            4884..5501
                     /locus_tag="GBW32_RS28435"
                     /old_locus_tag="GBW32_28425"
     CDS             4884..5501
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014142169.1"
                     /locus_tag="GBW32_RS28435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_28425"
                     /product="response regulator transcription factor"
                     /protein_id="WP_077967434.1"
                     /transl_table=11
                     /translation="MIRVLVVHSVKLFGSALAALLRAEGSFDVRVAPGLSGTGWGGGEL
                     PDVYVVDVECAGSATLMQDIASAAPGADHAPHKGALLVLVTADRPGMLRKAFDSRALGY
                     VDKNNGAEGRLADAIRIVAKGERFVDESLAFGFLRASDVPLSARELTVLSLAAEGQSIG
                     DMARGLRLSSGTVRNYMAAATRKVGARNRMDAVRISREAGWL"
     gene            complement(5470..7614)
                     /locus_tag="GBW32_RS28440"
                     /old_locus_tag="GBW32_28430"
     CDS             complement(5470..7614)
                     /EC_number="7.-.-.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016827682.1"
                     /locus_tag="GBW32_RS28440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_28430"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_227025325.1"
                     /transl_table=11
                     /translation="MTGHDVGRRRGGGPAGSVRHVRAGAGAGALRRLLPDARGFAGEHR
                     RAVGGLALWSLLESAQTFLGGYCVAHALDGGFLRGRPGTGLLWLAVAAVAVLVGGAALR
                     GVFAGLAGLVEPLRDGLVRRTVRRSIGGARGRDKEPDAAAVSRLTHQSEIARDGFAGIL
                     LTLRSFVFTALGALAGLASLAPVLLWVVVPPLVAGVGLFLATLRPMAGRQREFLDADEA
                     LAAQAGEVAAGLRDVAACGAREVVTARAAELVSAEADAARALARWSAARTLALGVAGQL
                     PVLLLLVTAPWLLGKGVTAGALLGGLTYLTQALLPALHSLMTGLGAAGTRLVVVLDRFV
                     TPPDGLPEDPGAATEPDVPPTPPTSRTRPTSRTRPTPPTPPTPLARASPTPRTPPHPRL
                     ARVNGAPADGQATARGAHDGDGRTGGRRGGRDGRTGTGADRGTAPGGDNGTAPGRTTDS
                     GDTSTDRTTAPAAELRGVTFAYGPRARPVIDGLDLSVMPGEHIAVVGPSGIGKSTLTAL
                     LAGVLTPHGGTVLLHGAPIGGRSPAELSGERVLVPQQAYVFTGTFRENLTYLRPDAAHE
                     ELVAAVDAVGAMPLLDRFGGPDAPLDPARLSPGERQLVALVRVRLAAAPRLLLDEATCH
                     LDPAAEARAEAALAARAGTLIVVAHRLSSARRAERVLVLDGSRAAYGTHGELIETSALY
                     RDLAGVSAGLPTASQPRARS"
     gene            complement(7611..9413)
                     /locus_tag="GBW32_RS28445"
                     /old_locus_tag="GBW32_28435"
     CDS             complement(7611..9413)
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016570340.1"
                     /locus_tag="GBW32_RS28445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_28435"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_077967435.1"
                     /transl_table=11
                     /translation="MPLERPAPRTEPTRGRPERRPAPDVAQGRGKDRHGLLRSVVRHSA
                     GRAAAVFLAGALSAAAAVAAPAVLGRTVDLLLSPQAGRPAGPWLLLSAVLIGAEVFLDA
                     GVALLGGNTGARSTAWLRRGAYARLLAAEPRHAAAFAPGDLATRLTVNAADTGTAPVTL
                     AGACASLLPPLGGLVGLFLVDAWTAVAFVAGIPVLLLVLRAFTRGSTDATARYQRVQSL
                     IADRLTEAMAGARTITAAGTERREQERVLAPLAGLGVEGRRTWRVYGRAVSHAGMLMPL
                     LTTVVLAVGGVRLAGGHLSPGDLLAASRYATLAAGIGTLTGALNALVRSRVAASRVGAL
                     LELSAVAYGDATLPQEGPGTVELRGVGVVRAGATVLDDVSLVIPGGSVVAVVGRSGSGK
                     STLAAVAGRLTDPDRGRVLLDGVPLDALDAGVLRRAVGYAFERPALFGQDVGDAIAFGA
                     HRPADEAVRSAAGAADADGFVALLPDGYATPLAEAPLSGGETQRLGLARAFAHAGRLLI
                     LDDATSSLDTVTERRVTRALHHEVRAGTRLIVAHRPSSCTGADLVVWLEDGRVRGTGLH
                     QELWRDAGYRAVFAAEGDGSVDSV"
     gene            complement(9835..9966)
                     /locus_tag="GBW32_RS28450"
                     /old_locus_tag="GBW32_28440"
     CDS             complement(9835..9966)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015611153.1"
                     /locus_tag="GBW32_RS28450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_28440"
                     /product="SapB/AmfS family lanthipeptide"
                     /protein_id="WP_077967437.1"
                     /transl_table=11
                     /translation="MALLDLQSMDTPQEEAVGDIATGSQVSLLICEYSSLSVVLCTP"
     CDS_motif       complement(9901..9966)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MALLDLQSMDTPQEEAVGDIAT"
                     /locus_tag="GBW32_RS28450_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(9835..9900)
                     /prepeptide="core"
                     /locus_tag="GBW32_RS28450_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="29.60"
                     /molecular_weight="2090.4"
                     /monoisotopic_mass="2089.1"
                     /core_sequence="GSQVSLLICEYSSLSVVLCTP"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MALLDLQSMDTPQEEAVGDIAT"
                     /leader_location="[9900:9966](-)"
                     /alternative_weights="2108.5"
                     /alternative_weights="2126.5"
                     /alternative_weights="2144.5"
                     /alternative_weights="2162.5"
     gene            complement(10001..12727)
                     /gene="lanKC"
                     /locus_tag="GBW32_RS28455"
                     /old_locus_tag="GBW32_28445"
     CDS             complement(10001..12727)
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007446862.1"
                     /locus_tag="GBW32_RS28455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_28445"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_077967439.1"
                     /sec_met_domain="micKC (E-value: 7.1e-224, bitscore: 744.1,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 2.5e-09, bitscore: 35.5,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 1e-10, bitscore: 39.6,
                     seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNPEYAAYCDADRLFYDAPHRAAEADDRSAGVFAATQRPVPHGWE
                     RHSRGDWLAYSPIGDRLPAQGWKIHVSATLDNADAVLSRVMEYCVERRIPFKCVPNRRL
                     LLLRNAKYADRAASGKFLTVYPADDDRCRVTAEELDELLGGEPGPYILSDLRWNAGPVH
                     LRYGSFASRFCLDERGELCPAVENPQGRLVPDPRGPVFEIPEWVAPPDFLAPHLRARSQ
                     VGLGDVPYTVERALHFSNGGGVYAGRVTATGEKVVLKEGRPYAGLAADGADAVTRLGRE
                     RATLERLAGLDCVPRLHGTFVLGDHHFLVEEFVPGTTLNTVFARRFPLAEADVDAGRLT
                     EHVAWAQRMYTLVERAVHAVHARGIAIGDLHLSNVMVSEDESSVVLLDFEAAFPAEEMR
                     RQSVANPAFLAPADRRGTAIDSYALACLRFALFTPLTTLFGIDRRKAAHLAEIIAEVYP
                     VDAAVFDGAVAEVLRGALPATPESGTRDPAAPDPAMPQAAAPVSGTPQAGTRATGPVAA
                     RPHGGRPPVAVEDWPRSRDSMVAGILASATPEREDRFFPGDIAQFATPCGGQSFGYGAA
                     GVLYALRVTGAERCQDAEEWLLAKAKEPSSGTPAGFYDGLSGIAWTLHLLGHHAQAGEL
                     AHLVTRQPLDGLPAELHGGLAGIGLALDSLAESSDDGTLRAAALRCAELAMDRAGRPGG
                     GSERERTGLLRGGSGLALFLIRMYEKSGDAALLDGAADALRRDLARCVPDERGVLLVRE
                     GTRAMPYLGAGSAGIAMVLDDWLAHREDEEFERARAGLLPAARSPFYIQPGLFRGVAGL
                     VLHLGRTTLPSSDGYAADLRRHERLLGWHALSYQGHLAFPGEQLTRLSMDLSTGTAGCL
                     LALGSLRDPRAHLPFLPPHPRRPQSRPPRGVERNTRT"
     cand_cluster    10894..22549
                     /candidate_cluster_number="2"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    10894..22549
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[15893:17549](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      complement(15894..17549)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="2"
     misc_feature    12801..12818
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 16.7"
                     /tool="antismash"
     gene            complement(13115..14758)
                     /locus_tag="GBW32_RS28460"
                     /old_locus_tag="GBW32_28450"
     CDS             complement(13115..14758)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (115-489). E-value:
                     6.2e-22. Score: 70.3. Matches aSDomain:
                     nrpspksdomains_GBW32_RS28460_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016824197.1"
                     /locus_tag="GBW32_RS28460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_28450"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_077967440.1"
                     /sec_met_domain="PF00561 (E-value: 1.1e-25, bitscore: 89.4,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRAPLTPLLYGTAGSLLLTALVAAPAGGASGRSTPPEHVAEARGT
                     ALAAERAAAKGIAFGACPKSEGLPSVVKCGTVSVPFDYADPDGRQIKLTVSRAKPAKPK
                     KGAKAAPPHQGALVFNPGGPGASGMYFPLVSTLPEWKKLAGSYDLVGYAPRGVGRSAPL
                     SCQDPKEYGKAPSQSPTHPDEAYKAERVAQAKAYARDCGRSAGEGLRQYTTLNNARDLD
                     VLRAGLGEKRLTFMGASYGTYFGAVYATLFPGHVRRMVFDSAVDPDPEQIWYRNNLDQS
                     VAFENRWTDFREWVASHDATYHLGTTVDDVQKNFDKAKDKLARKPAGGTVGPGQLQGAY
                     LQAGYYDDYWASRAHALSRYLKGDPKPLVRLAAPVPEAAKESENGNAVYTAVECNDAPW
                     PTEWRTWDEDNTRLARIAPFETWDNAFMNLPCAYWPAPRQRPVDVGTDPGELAPTLILA
                     AERDAATPYQGALELHRRLAGSTVVTERGAGTHGIAGGPNKCVNAYVDAYLLDGKLPEG
                     DADCQGRQAPKPDTDSKAGRSHAKALPRAS"
     aSDomain        complement(13292..14413)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_GBW32_RS28460_Abhydrolase_1.1"
                     /evalue="6.20E-22"
                     /label="GBW32_RS28460_Abhydrolase_1.1"
                     /locus_tag="GBW32_RS28460"
                     /protein_end="489"
                     /protein_start="115"
                     /score="70.3"
                     /tool="antismash"
                     /translation="ALVFNPGGPGASGMYFPLVSTLPEWKKLAGSYDLVGYAPRGVGRS
                     APLSCQDPKEYGKAPSQSPTHPDEAYKAERVAQAKAYARDCGRSAGEGLRQYTTLNNAR
                     DLDVLRAGLGEKRLTFMGASYGTYFGAVYATLFPGHVRRMVFDSAVDPDPEQIWYRNNL
                     DQSVAFENRWTDFREWVASHDATYHLGTTVDDVQKNFDKAKDKLARKPAGGTVGPGQLQ
                     GAYLQAGYYDDYWASRAHALSRYLKGDPKPLVRLAAPVPEAAKESENGNAVYTAVECND
                     APWPTEWRTWDEDNTRLARIAPFETWDNAFMNLPCAYWPAPRQRPVDVGTDPGELAPTL
                     ILAAERDAATPYQGALELHRRLAGSTVVTERGAG"
     gene            complement(14908..15714)
                     /locus_tag="GBW32_RS28465"
                     /old_locus_tag="GBW32_28455"
     CDS             complement(14908..15714)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016824196.1"
                     /locus_tag="GBW32_RS28465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_28455"
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_077967442.1"
                     /transl_table=11
                     /translation="MLWIPLLLVACASTGLACARLCLAAIRAGETAPSVEVSEADARIL
                     AAYELPLHEAAYLSGGPLRAVDVTLVAMARGRRLLLARTGWATVVDPRGRNDLERAVLL
                     ALGVRGQELIAVVRAAVATSDAVRALAERLNTAGLAVPDRARENVASATRQVAWTALAL
                     PALTALALLSPSAAPGTPGTEIVAWFSLPAVLALGCLVVARIEVHPYTRWASPVGQRLL
                     GAFVARERTGEGGAALVAVAVRGVRALRDPALSAAFARRRPPQRAQ"
     gene            complement(15894..17549)
                     /locus_tag="GBW32_RS28470"
                     /old_locus_tag="GBW32_28460"
     CDS             complement(15894..17549)
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017944755.1"
                     /locus_tag="GBW32_RS28470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_28460"
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_077967444.1"
                     /sec_met_domain="DUF692 (E-value: 5e-94, bitscore: 313.1,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEYHGQLGTGIGWRPEIASAVERMPGVDWVEAVAENLCPGHLPDS
                     LVRLRERGVTVVPHGVGLGLGGADRPDPERLAALAERALALESPLVTEHIAFVRAGGPQ
                     IAAPSLEAGHLLPVPRTRDALDVLCENVRIAQDALPVPLAVENIAALFPWPDEELTEGQ
                     FLRELVERTGVRLLIDVANLHTNHVNMGQDPATALSQLPVEAIAYVHVAGGFERDGVWH
                     DSHAHPVPEPVLGILADLCSRTRPPGVLLERDENFPDPAELEDELDAIRATVRSGAGSG
                     QSVLVSTPAREAATAPAEHVAEDEVLIVTSAAAGPAEDMVMVVTAAPPATAPRTATEQA
                     AESGPLVEGANFADGSGAGARSEAGYAAGGAAGPEAAAVDWPAPYADDPRDGSLGDGAL
                     FVVGGPGSSEGPSDSGARDRLGYGQYALLAALVDAGPVPEGFDPARLGVQSRALAAKRA
                     DVVAKVAPELPEILGDGYRAHFLDYARTRPLTGGYRKDALDFAEFLLTAARPAGGSTRR
                     RLSTWWLERSGPEPLPSGAVRRLARAARSVLLRR"
     gene            complement(18183..18875)
                     /locus_tag="GBW32_RS28475"
                     /old_locus_tag="GBW32_28465"
     CDS             complement(18183..18875)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019356867.1"
                     /locus_tag="GBW32_RS28475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_28465"
                     /product="DUF3159 domain-containing protein"
                     /protein_id="WP_077967655.1"
                     /transl_table=11
                     /translation="MKTVSFLETESDTQVERTEQTAPRQRPSVLDQAGGTKGVVYSALP
                     VVAFVVANSVGGLRMAVIAALAVAVAIGVERLLRKESVQPAIGGVFGVAIAAGVVWLTG
                     SAKDYFLIGIWASLAGAVLFLLSVLARWPMAGVIWNVATGKGNVWRADKRSRLYYDIAT
                     LVLAAVFGARFAVQQYFYATDQVGSLGFAKIAMGFPLLALALLVVAWAARSSNKRLAAI
                     GLLPAKRS"
     misc_feature    18913..18923
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 19.65"
                     /tool="antismash"
     misc_feature    18932..18952
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 22.03"
                     /tool="antismash"
     misc_feature    18943..18959
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.3"
                     /tool="antismash"
     misc_feature    18950..18970
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.16"
                     /tool="antismash"
     misc_feature    18953..18965
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 18.88"
                     /tool="antismash"
     misc_feature    complement(18981..18996)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: strong, score: 19.26"
                     /tool="antismash"
     misc_feature    complement(19136..19148)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 22.29"
                     /tool="antismash"
     misc_feature    complement(19142..19158)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.1"
                     /tool="antismash"
     misc_feature    complement(19212..19222)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     gene            19217..21103
                     /locus_tag="GBW32_RS28480"
                     /old_locus_tag="GBW32_28470"
     CDS             19217..21103
                     /EC_number="3.4.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S9"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003949694.1"
                     /locus_tag="GBW32_RS28480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_28470"
                     /product="S9 family peptidase"
                     /protein_id="WP_077967446.1"
                     /sec_met_domain="PF00561 (E-value: 0.00012, bitscore: 20.4,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_S9 (E-value: 1.4e-50, bitscore:
                     170.4, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAPRETISVEEFFGPPLRAKTTLSPDGRKMAYLALWENRLNVWIE
                     SVDTPGDSRCVTTEDRGVLSYHWTRDPRWLLYTRDQGGDENMHLYRVDLEDPDAAAVNL
                     TPYPGVRTLGLDLPAGRPGKVITQLNLRDRAQFDLVELDIATGDLTTLAKNPGSEVEGW
                     LYSERDLFAGGTTAEGDVLLSKWDAATGALDPVARFDGGDAPLGIYPLEVTPDGGGVWL
                     GSYRGGDRLRLARLDLATGEEEEVDSHPRYDLDTRAQVFPALPSPLIRSRRTGELLGVR
                     YLGERQVIHALDPHFAAVLKNLEKLSDGDLAGLSSDESGQRWVAGFTHDRDPGATFLYD
                     HTTGESRLLHRARPHLDPESLAPMRPVEITSRDGLTLPSYLTLPVGIEPSRLPLVLFVH
                     GGPWSRDSWGYHPAAQLFANRGYAVLQVNFRGSTGYGRAFTRAAIGEFAGKMHDDLIDG
                     VRWAVERGYADPDRVAIMGGSYGGYASLAGVTFTPDVFAAAVDVVGISDLANFMRSQPD
                     FVKPMLTHNWFTYVGDPADPEQEADMLARSPITRVDQIRTPLMVVHGANDARVVLAESD
                     LLVEALRARGVPVEYTVMRDEGHAIENPENVIALYTGVERFLAEHLGFEARS"
     gene            complement(21325..22161)
                     /locus_tag="GBW32_RS28485"
                     /old_locus_tag="GBW32_28475"
     CDS             complement(21325..22161)
                     /GO_function="GO:0004045 - aminoacyl-tRNA hydrolase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010983656.1"
                     /locus_tag="GBW32_RS28485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_28475"
                     /product="peptidyl-tRNA hydrolase"
                     /protein_id="WP_107502785.1"
                     /transl_table=11
                     /translation="MSSDDIPSTPADGVQTSPSAPADTTPGAAEGGAPEPGPGRVRGAD
                     TQDSPFVNEPTERDEAPQFVLPLVVRLERADPPARTDAMETAARAVLALLSDERSVGDG
                     EWAEAVRDWQDARIRKVVRRARGAEWRRTGTMPGITLTGKAAEVRVFPPIPVDGWPKDL
                     AKLQVSGTELDDPEPPSAPDPGVPVLWMSPDVTMSAGKAMAQAGHAAQLAWWELSPAER
                     DAWREAGFPLAVRTAAPAHWRTLVTSGLPVVQDAGFTEIAPGSCTVIADHPALREG"
     misc_feature    complement(22295..22307)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 20.88"
                     /tool="antismash"
     misc_feature    22635..22650
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.63"
                     /tool="antismash"
ORIGIN
        1 ccgcgtagat ctcctcgtga ccgcgcaccc gcatcgccag atccgtgagc agtccgcccg
       61 cggggccgag cgccagcccc gccgccccgg cgagggacgt ctcagggcgc accccgatgc
      121 cgaggaccac cacgtccgcc ggatactcgg ccgcctccgt gcgcaccgct cgcacccggc
      181 cgtcgtcgcc ggtcagcagt tcggtgacgg cggcgtcgtt caccatcgtg atgcccatgc
      241 ccgtcatcgc gtcgccgacc aggtggccca tgtccgggtc gagtgtcgac atcggctggc
      301 cggcgcggtt gaccatggtg acgtcgtagc ccttgcggat cagggcctcc gccatctcca
      361 cgccgatgta gccggcgccc acgacgacgg cgcgcaggcc ggccgtggcc cgcagcgacg
      421 cgagcagcgt ctcgccgtcg ccgagcgtct gcaccccgtg cacgccgggc gcgtcgatcc
      481 cgggcagctg cggcctgatc ggccgtgcgc ccgtcgcgat gacgaggtgg tcgtaggagg
      541 tccagtactc ctcccccgag tcgacggagc gggcgcgcac cctgcgtccc tccgtgtcga
      601 tctctgtcac ctcggtgccg gtgcgcagat cgataccgcg tttcctgtgc tcctcgggcg
      661 accgcgcgat cagcccgtcg ggcccgtcga cgtcgcctcc cacccagtag gggataccgc
      721 acgcggagta cgacgtgaag cgcccccgtt cgaaggcgac gatctccagt tcctcctgcc
      781 ccttgagcct gcgggcctgc gacgcggcgg acatgcccgt cgcgtcgcct ccgatgacga
      841 ccagtcgttc actcataggc acacgctacg tgcggcggcc cggtgcttcc ccgccctcgt
      901 cgccgccacg tgggtggggt tccgcctcgt ccgcgcccgt ccgcccggtc ccgccggggc
      961 cggccggctc cgccggtccg gcggacgcga cgggctccgg cgtcgcgccg ccgcgtggct
     1021 cggcgagggc gtgccacgcg ggcgaggccc cggcggccgc ggggcgggcg cgccggggca
     1081 gacgcccacg gaacagccgc cacagcacca gcgtcacggc ccccgccgcg aggaacggca
     1141 gcgccgcccc gacagcgagc gccacaccgc gcgcgatcgt cacgaagacg tcccagccgc
     1201 cgcccagcgc gtcggtgaag ccgctctcct cctcgtgccc gcctggcgcc gtacccgccc
     1261 tctgcgacag ccgcagcgtg atcgtggcca tgctggtgcg gtccttcagc gacgcctgcc
     1321 gggccagcag cgattcgagg tccgcctcac gggtactcag ttcgccctca agggccacga
     1381 cgtcgctgat cctcttcgcg tcgtccatca gcgcccggac ccgtgccacg ctcgcccgct
     1441 gggactcgac ccggctgtcc acgtccacca cctgctcgga gacgtcccgc gccttgacct
     1501 ttcgctcgac aagggtgcct gtgcccgcga gtgcggccag cacctcgtcg taggaggacc
     1561 gagggacgcg cagcacgatc cgtgaactct cccgtccctc cccgtccctg tccgtggtct
     1621 cgtcgccgac gatcccgccc gcgtcccgcg ccgccgcacg ggcggcgtcc agggcgtcgg
     1681 ccacatcctt gacccggacc ctcagggagg cggtgcggat gaggtgcgta cccgccgcgt
     1741 ccggcagccg gccggccgtc ctcccgtccg cgcgcccgac cgactcccgc gccgccgagc
     1801 ccggtcgctc cgcccccggc cccgccgcgc cccctttccc gtcgtcgccc gcggcgggcc
     1861 gccccgccct ggagtcgccg cccgcgtcgc cgtccccact cgccccgccg cccgaacagc
     1921 ccgccacggc cagcgccccg gccagcagca tcccggcgag ggcccgcgcc ccgcgcccgg
     1981 cgaccggccc cccgcgcacc cgcgccgtac cgggctcgcc ccacccgctc gcgccgtaca
     2041 ccggcgccgg tcgcacactt cgcacaggtc ccccaaggtt tcgcggcgcg ttgcctcttc
     2101 ggtcgctcct acgacgcggg ggccgcgccg ggggatcggg ccgcgcggtc gcgatgtggt
     2161 cacgttccgg actcgtcccg gtcgccgccc gctcccgccc cgaaccggag ccgaggccac
     2221 cgggcgcttc tgagacagtg ggaaccatgt gcgcagcggt gacggagaca ggtcagagcc
     2281 ggacggggac gccccacgta gtggtcgtgg gcggtggtat cgcggggctc gccgccgcgc
     2341 accgggccct cggggcgggg gcgagggtca cggtgctcga agcctcgccg cggctcggcg
     2401 gcaagctgca cgcgggggag atcgagggcg tacgggtcga cctgggtgcg gagtcgatgc
     2461 tggcccgccg cccggaagcc gtcgatctcg cccgcgaggt cggcctcggc gaactgctcc
     2521 agccgccggg caccgcgacg gccgccctgt ggaccagggg agaactgcgc cccatgccca
     2581 aggggcacgt catgggcgtg cccggtgacg ccgccgcact ggcgggcgtg gtctccgcgg
     2641 aggggctgcg caggatcgcc gaggacagcg aactccccgc caccgaggta ggcgaggaca
     2701 tcgccgtcgg ccgctacgtc gcggaccggc tcggccgtga ggtcgtcgac cggctggtgg
     2761 aaccgctgct cggcggtgtc tacgccggtg acgcctaccg catctcgatg cgcgccgcgg
     2821 taccgcagct cttcgaagtg gcccgcaccc acaggtcact gaccgagggc gtccgcgaca
     2881 tccaggcgcg ggccgggaaa caacagggcg cggtccccgt cttcatgggc atcgagggcg
     2941 gcatcggcag gctgccgctc gccgtcgccg actccgtgcg cgcccgcggc ggcgacatcc
     3001 tgaccggcgc ggccgtcacc gaactgcgcc gcacaggggc ggggcagaac ggcgccggat
     3061 ggcggatcgt cgcgggcgag tcggtcttcg aggccgacgc cgtggtgatc gccctccccg
     3121 cgccgcacgc cgcccggctg ctcgccgccg aatcgcccgc cgccgcggcg gaactcaccg
     3181 ccgtcgagta cgcgtcgatg gcccttgtca ccctcgcgta ccgcacggag gacgcggcga
     3241 cgctgccctc gggaagcggc ttcctcgtcc cccccgtcga cgggcacacc atcaaggcgg
     3301 ccaccttctc ggccaacaag tggggctgga gcgcggcgga gaaccggggg ctgcgggtgc
     3361 tgcgcacctc catcgggcgc tacggcgacg aggacgacct gtcccgcgcc gacgacgacc
     3421 tcatcagggt cgcccggggt gacctgcgcg ccgcgaccgg actcgacgcg ctccccgtcg
     3481 cagcccgggt gacccgctgg gaccagggcc tgccccagta tccggtgggc catcaggcgc
     3541 gggtggcccg cgtccgccgc tacgtcggcg cgctgccggg gctcgccgtc tgcggcgccg
     3601 cctacgacgg tgtgggcatc cccgcgtgcg tcgcgagcgc ggccgcggcg gtcgacctgg
     3661 tcgtaggacg gggcccggcg tcgagcacgg cggacggcgc gcgagaatag ccccatgagt
     3721 gctgcccccg agaagccaga gaaggcccag aacgccggta agaaggcgaa ggacctcaac
     3781 gacgtcatcc gctacaccct gtggtcggtc ttcaagttgc gcgacgcgct gcccgaggac
     3841 agggccggct acgccgacga ggtgcgggag ctgttcgacc agctcgccgc caaggacgtc
     3901 acggtgcgcg gcacctacga cgtgtcgggg ctgcgcgccg acgcggacct gatgatctgg
     3961 tggcacgcgg agacgtcgga ccagcttcag gaggcgtaca acctcttccg ccgtacgagg
     4021 ctcggccgct ccctcgaacc ggtctggtcg aacatggcgc tgcaccgccc cgccgagttc
     4081 aacaagtcgc acgttcccgc gttcctcgcc gacgagaccc cgcgcgacta cgtgagcgtg
     4141 taccccttcg tacgctccta cgactggtac ctgctgcccg acgaggagcg caggaccatg
     4201 ctggccgacc acggcaagat ggcccgcggc ttccccgacg tacgcgccaa cacggtcgcc
     4261 tcgttctcgc tcggcgacta cgagtggatc ctcgccttcg aggccgacga gctgtaccgc
     4321 atcgtcgacc tcatgcggca cctgcgcgga tccaaggcgc ggctgtacgt ccgcgaagag
     4381 gtgcccttct acaccggccg ccgcaggtcc gtggcggagc tggtggcggg gctcgcctag
     4441 aggacgaccc ggtcaggggc gaccccggtc ggggaggatt cccggccacg tgcgggaggg
     4501 cgcggttcgc gtgagccgcg ccctcccgca cgtccgtatc cggacacacc gctgcctgtc
     4561 cctgtcgtat cggaaaacgc tttcggtata tgcgaaacgt ttcgtgcgcg tggccgcagt
     4621 atttcagcca tttatccgtg gccgatcctc ggtggtgcgc aatcgttcga gctcgcggga
     4681 gccttcaagg ccagcacagg gggtgcgtag aaagtaaacc ccgaaaatat gtgcgtatag
     4741 ttccgccttt ctggattcgc catgtcgtgc gaatcgtctc cctgcgcgcc accggccgtg
     4801 cactctggga actccggtgg aaagcccgtc cgccctgatc cgatccggtc aggcggcggg
     4861 cgcgtggcga gaggcgtggc gacgtgatcc gagtactcgt ggtgcattcg gtgaagctgt
     4921 tcggatccgc cctcgcggca ctcctccggg cagagggctc cttcgacgta cgcgtggctc
     4981 ccggcctctc ggggaccggg tggggcggcg gagaactgcc cgatgtctac gtggtcgatg
     5041 tagagtgcgc gggctccgcc accctcatgc aggacatcgc ctcggccgcc cccggagccg
     5101 accacgctcc ccacaaggga gcccttctgg tcctcgtcac cgccgaccgg cccgggatgc
     5161 ttcgcaaggc attcgattcg cgggcactcg ggtacgtcga caagaacaac ggcgcggagg
     5221 gaagactcgc ggacgccatc cgaatcgtgg cgaaaggcga gagattcgtg gacgaatctc
     5281 tcgccttcgg ctttctgcgg gcctcggacg ttccgctctc cgcgcgcgag ctgaccgtgc
     5341 tctccctggc cgccgagggc caatccatag gcgatatggc gcggggactg cggttgtcgt
     5401 cgggaaccgt gcggaactac atggccgccg ccaccaggaa ggtcggggcg cgcaaccgca
     5461 tggacgcggt caggatctcg cgcgaggctg gctggctgta ggaagcccgg ccgacacccc
     5521 cgccagatcg cggtagagcg ccgaggtctc gatcagttcc ccgtgggttc cgtacgcggc
     5581 cctgctgccg tccaggacca gtacgcgctc cgccctgcgc gcggaggaca gccggtgcgc
     5641 gaccacgatc agcgtgcccg cgcgcgccgc gagcgccgcc tcggccctcg cctccgccgc
     5701 gggatcgaga tgacaggtgg cctcgtcgag caggagccgc ggcgccgcgg cgagacgcac
     5761 cctgaccagg gcgacgagct gccgttcccc cggggagagc cgcgcggggt cgagcggcgc
     5821 gtccgggccg ccgaaccggt ccagcaacgg catcgccccg acggcgtcca cggccgccac
     5881 cagctcttcg tgcgccgcgt cgggccgcag ataggtcagg ttctcgcgga acgtccccgt
     5941 gaacacgtac gcctgctgcg ggacgagcac ccgctctccg gagagttccg ccgggctcct
     6001 gcccccgatc ggggcgccgt gcagcaggac cgtgccgccg tgcggggtca gtacccccgc
     6061 gagcagcgcc gtcagggtgg acttgccgat gccgctcggc cccacgaccg cgatgtgctc
     6121 accgggcatg accgacagat cgagtccgtc gatcacgggc cgggcccgtg ggccgtacgc
     6181 gaaggtcacg ccccgcagct cggcggcggg ggcggtggtg cggtcggtgc tcgtgtctcc
     6241 gctgtcggtg gtgcggcctg gggccgtgcc gttgtcaccg cctggggccg tgcctctgtc
     6301 ggcgccggtg cccgtccgcc cgtcgcggcc gccgcgtcgt ccgcccgtcc gtccgtcgcc
     6361 gtcgtgcgcg ccccgcgctg tcgcctgtcc gtcggccggg gccccgttca cgcgcgcgag
     6421 gcgcgggtgc ggaggggtac ggggcgtcgg cgacgcccga gccagtgggg tcggcggggt
     6481 cggcggggtc ggtcgggtcc gtgaggtcgg tcgggtccgt gaggtcggcg gggtcggcgg
     6541 gacgtcaggt tcggtcgcgg caccgggatc ctcggggagg ccgtcgggcg gggtcacgaa
     6601 ccggtcgagc accaccacca ggcgcgtacc cgccgcgccg agccccgtca tcagggagtg
     6661 cagcgcgggc agcagagcct gcgtcagata ggtgaggcca ccgagcagcg cccccgccgt
     6721 cacccccttc cccagcagcc acggcgcggt caccaggagc agcaggacgg ggagctgacc
     6781 cgcgacgccc agcgccaggg tgcgcgccgc cgaccaccgg gccagcgcgc gggcggcgtc
     6841 cgcctccgcg ctgacgagtt ccgcggcgcg cgcggtcacc acctcgcgcg cgccgcacgc
     6901 cgccacgtcc cgcagcccgg cggcgacctc tccggcctgc gccgccagcg cctcgtcggc
     6961 gtcgaggaac tcacgctgac gccccgccat cggcctgagc gtggccagga acagaccgac
     7021 ccccgccacc agcggcggaa ccaccaccca cagcaggacg ggggcgagcg aggccagccc
     7081 ggcgagcgcc cccagagccg tgaacacgaa cgaacgcagc gtcaggagga tccccgcgaa
     7141 gccgtccctg gcgatctccg actggtgcgt cagccgtgac accgcggcgg cgtcgggttc
     7201 cttgtcccgt cccctcgccc caccgatcga gcggcgcacc gtccgtcgca ccaatccgtc
     7261 gcgcaagggt tccacgagcc cggcgaggcc cgcgaagacc ccgcgcagcg cggcgccgcc
     7321 gaccaggaca gcgacagcgg cgaccgccag ccacagcagc cccgtccccg gccggccgcg
     7381 gagaaaaccc ccgtcgaggg cgtgcgccac gcagtatccg ccgagaaagg tctgcgccga
     7441 ttcgagcagg gaccacagcg cgagcccgcc gaccgccctg cggtgctccc cggcgaaccc
     7501 gcgggcgtcg gggagcagcc gccgcagggc gcccgcgccg gccccggccc gtacgtggcg
     7561 tacggagcct gccgggccgc ccccgcgcct tcgccccacg tcgtgcccgg tcatacggag
     7621 tccacactcc cgtccccctc ggccgcgaag accgcacggt aaccggcgtc ccgccacagc
     7681 tcctggtgga ggcccgtacc gcgcacccgg ccgtcctcca gccagaccac cagatcggcc
     7741 ccggtgcacg aggacggacg gtgcgcgacg atcagcctgg tgcccgcccg cacttcgtgg
     7801 tggagggccc tggtgacgcg ccgttccgtg acggtgtcga ggctcgacgt ggcgtcgtcg
     7861 aggatcagca gccgcccggc gtgcgcgaag gcccgtgcca gccccagccg ttgggtctcc
     7921 ccgccggaca gcggtgcctc ggccagcggg gtcgcgtatc cgtcgggcag cagcgcgacg
     7981 aacccgtccg cgtcggcggc gcccgcggcg gagcgtaccg cctcgtccgc cggccggtgc
     8041 gcgccgaacg cgatggcgtc gccgacgtcc tggccgaaga gggcgggccg ttcgaacgcg
     8101 taccccaccg cgcggcgcag caccccggcg tccagcgcgt ccaggggcac cccgtcgagc
     8161 agtacccggc cgcggtccgg gtcggtgagg cggcccgcga cggcggccag cgtcgacttg
     8221 cctgagccgg agcggcccac caccgcgacg acggacccgc cggggatcac cagactgacg
     8281 tcgtccagta cggtcgcccc cgcgcgtacg acaccgacgc cccgcagttc gacggtgcct
     8341 ggtccttcct ggggcagggt ggcatcgccg tacgccacgg cggacagttc gagcagcgcc
     8401 ccgacccgtg acgcggcgac ccggctgcgt accagcgcgt tcagcgcgcc cgtcagggtg
     8461 ccgatccccg cggcgagcgt cgcgtagcgg gaggccgcca gcagatcacc ggggctcagg
     8521 tggcccccgg cgagccgcac cccgccgacc gcgaggacca ccgtggtgag caggggcatc
     8581 agcatccccg cgtgggagac ggccctgccg tacacccgcc aggtcctgcg gccctccacc
     8641 ccgagaccgg cgagcggtgc gaggacccgc tcttgttcgc gccgttcggt accggccgcc
     8701 gtgatggtcc gcgcgcccgc catggcctcg gtgaggcggt cggcgatcaa ggactggacc
     8761 cgctggtagc gcgcggtcgc gtcggtggag cccctggtga aggcgcgcag caccagcagc
     8821 agcacaggga tgcccgccac gaacgcgacg gccgtccagg cgtccacgag gaagagcccc
     8881 acgagcccgc cgagcggggg gagcagggag gcgcacgcgc ccgcgagggt cacgggagcc
     8941 gttcctgtgt cggcggcgtt gaccgtcagc cgggtggcga ggtcacctgg ggcgaaggcc
     9001 gccgcgtgcc tgggctcggc cgcgagcagc cgtgcgtacg cgccgcgccg cagccacgcc
     9061 gtggacctgg cgccggtgtt cccgcctaga agcgccaccc cggcgtcgag gaacacctcg
     9121 gcgccgatca gtaccgcgga gagcagtagc caggggccgg cggggcggcc ggcctgcggg
     9181 gagaggagca ggtcgacggt cctgccgaga acggcgggag cggccaccgc cgcggcggcg
     9241 gagagcgcac ccgcgaggaa caccgcggcc gcgcggcccg cgctgtgccg tacgacggaa
     9301 cgcagcagcc catgccggtc cttaccccgg ccctgcgcga cgtccggcgc ggggcggcgc
     9361 tccggccgac cccgcgtggg ctccgtcctc ggcgcgggac gctccagggg catttttcct
     9421 ggtctccttc gtggccgctg gtgggcgcgc ggggtcgtct cgtggccgcg cggggtcgct
     9481 cgtggtcgct tcagcgggac ggacggactc ggactcggcg ggcggccgag ctcgagggcg
     9541 gacggactcg cggcggacgg agccagggac cgcgacgcag tgcgcgccgc ccgcaccggc
     9601 ccgcgtcgtg cccggccccg acgagcccgc tacgagaagc gatccggctc cggaggagag
     9661 ggaagcgctg ctggcccggc ggaggaagcc ctccgatcgg cgcgaggggc ccggcgcgcc
     9721 tggtcccgga cggagaaacc gcccgggacc agggggaccg tcaatgacac ggcgagcggt
     9781 ggccgcgcca actcgggccg gtgcacaccc ccatggggcg gggcgtgcgg tcgatcacgg
     9841 ggtgcagagc accacgctga gcgagctgta ctcacagatg agcaggctca cctggctgcc
     9901 tgtggcgatg tcgccgacag cctcttcctg cggggtgtcc atgctctgaa ggtcgagaag
     9961 tgccatgggg attcctttct ggggacagtg gagccggatg tcacgtacgg gtgttgcgtt
    10021 cgacccctcg cgggggccgg ctctggggcc gccgcgggtg cggcggcagg aacggcaggt
    10081 gcgcgcgggg atcgcgcagc gagccgaggg cgagcagaca gcccgcggtg cccgtggaca
    10141 gatccatgga cagccgcgtc aactgctctc cggggaaggc gagatggccc tgataggaga
    10201 gggcgtgcca gccgagcagc cgctcgtggc gccggaggtc ggccgcgtac ccgtcggagg
    10261 aggggagcgt cgtacgtccg aggtggagca cgaggcccgc cacgccccgg aacaggccgg
    10321 gctggatgta gaagggggag cgcgccgcgg ggagcagccc tgccctcgcc cgctcgaact
    10381 cctcgtcctc gcggtgggcg agccagtcgt cgagcaccat ggctatcccc gcgctgcccg
    10441 cgccgagata cggcatggcc cgcgtcccct cccgtacgag cagtacgccc cgttcgtccg
    10501 gcacgcaccg cgcgaggtcg cgccggagcg cgtccgccgc accgtcgagc agtgcggcgt
    10561 cccctgactt ctcgtacata cggatgagga agagcgcgag gcccgagccg ccgcgcagca
    10621 ggccggtccg ctcgcgctcg gagccacccc ccggccgtcc cgcgcggtcc atggccagct
    10681 cggcgcagcg cagcgcggcg gcgcgcaggg ttccgtcgtc ggacgattcc gcgagggagt
    10741 ccagcgcgag accgatcccc gccagcccgc cgtgcaactc cgccgggagc ccgtcgaggg
    10801 gctgccgggt gacgaggtgg gcgagctctc cggcctgagc gtggtggccg agcagatgga
    10861 gggtccaggc gatgcccgac agcccgtcgt agaaaccggc gggcgtgccg gagctgggtt
    10921 ccttggcctt ggcgagcagc cattcctcgg cgtcctggca acgttccgca cctgtcacgc
    10981 gcagcgcgta gagcacgccc gcggcgccgt agccgaagga ctggccgccg cacggggtgg
    11041 cgaactgtgc gatgtcgccg gggaagaaac ggtcctcgcg ttccggcgtg gccgaggcga
    11101 ggatccccgc caccatcgag tcccgggaac ggggccagtc ctccacggcc accggtggcc
    11161 gtccgccgtg cggccgtgcg gcaaccggac ctgtggcacg cgtccccgcc tggggcgtcc
    11221 ccgagaccgg cgccgccgcc tggggcatcg cagggtccgg cgccgccggg tcccgcgtcc
    11281 ccgactccgg cgtcgccgga agtgctccgc gcagtacctc agcgaccgcg ccgtcgaaca
    11341 ccgccgcgtc caccggatac acctcggcga tgatctccgc gagatgcgcc gccttcctac
    11401 ggtcgatgcc gaacagtgtg gtcagcgggg tgaagagggc gaaccgcagg caggcgagcg
    11461 catagctgtc gatcgcggtg ccccgccggt cggcgggggc caggaacgcg gggttggcga
    11521 cgctctgacg ccgcatctcc tcggcgggaa aagcggcctc gaagtcgagc agcaccaccg
    11581 aggactcgtc ctcggagacc atcacattgc tcaggtgcag gtcgccgatg gcgatccccc
    11641 tcgcgtgcac cgcgtggacg gctctctcca ccagggtgta catccgctgg gcccaggcca
    11701 cgtgttccgt gagccgcccc gcgtcgacat cggcctcggc cagcgggaac ctgcgggcga
    11761 acaccgtgtt gagggtggtg ccagggacga actcctccac caggaagtgg tggtcgccca
    11821 ggacgaaggt gccgtgcagc cggggcacgc agtccagtcc cgcaagccgt tccagggtgg
    11881 cgcgttcgcg gccgagccgg gtgacggcgt cggcgccgtc ggcggcgagt cccgcgtacg
    11941 gccggccctc cttgaggacg accttctcgc cggtcgcggt cacgcgcccg gcgtagacgc
    12001 ccccgccgtt cgagaagtgc agagcccgtt cgacggtgta gggcacgtca ccgaggccca
    12061 cctgggacct ggcccgcaga tgaggggcga ggaagtccgg cggggcgacc cactcgggga
    12121 tctcgaagac cggtccgcgc gggtcgggca cgagccgtcc ctgggggttc tccaccgccg
    12181 ggcacagctc gccgcgctcg tcgagacaga agcgggaggc gaagctgccg taccgaaggt
    12241 gcacgggccc cgcgttccag cgcaggtcac tgaggatgta cggtcctggc tcaccgccga
    12301 gcagttcgtc gagctcctcc gcggtgacac ggcaacggtc gtcgtcggcc ggatagaccg
    12361 tcaggaactt gccactcgcg gcgcggtccg cgtacttggc gttgcgcaga agcagcagac
    12421 gccggttcgg tacgcacttg aaggggatcc ggcgctccac gcagtactcc atgacgcggc
    12481 tgagcaccgc atcggcgttg tccagcgtgg cggagacgtg gatcttccag ccctgcgcgg
    12541 gaagccggtc accgatcggg ctgtaggcga gccagtcgcc cctgctgtgc cgttcccatc
    12601 cgtgggggac gggccgctgg gtcgccgcga agactccggc ggaccggtcg tccgcttcgg
    12661 ccgcccggtg cggggcgtcg tagaacaggc ggtccgcgtc acagtaagcc gcgtactccg
    12721 gattcaccct cgcaccccct tcgttcgtcg tcgcaccgac gttcccacgg ggcaagtgga
    12781 ggcgaacagt caccgttgtc atgtcatgtc cgtgtgaaac gcatgacctc ggctgacggt
    12841 tctggagcgg gggacgggag tgggtcttgg agcgagggtc ccgtacgggg tggtggtgaa
    12901 cccggaacgg tggtggggag gccccgtacg ggacggaggg gaacccggga gggtggtggg
    12961 gaagcccctc actgggcggc gggggctgag aacggtatgg gaacggcagg ggagcacgcg
    13021 gagggagcac gtggacggcg cccgctcccc ggtggcgaag cagggggagc gggcgccgtt
    13081 cgtgggccga tcggtggggc ggctgacctg cgactcagct cgccctgggc agcgccttgg
    13141 cgtgcgaacg tcccgccttg ctgtccgtat cgggcttcgg tgcctggcgt ccctggcagt
    13201 cggcgtcgcc ctcgggcagc ttgccgtcca gcagataggc gtcgacgtac gcgttcacgc
    13261 acttgttcgg gccgcccgcg atcccgtggg tgcccgcgcc ccgctcggtc acgacggtgg
    13321 aacccgccag cctgcgatgg agttcgagtg ccccttggta gggcgtggcc gcgtcgcgct
    13381 ccgccgcgag gatcagggtc ggcgcgagct cgccggggtc cgtacccacg tcgacggggc
    13441 gctgcctggg ggcgggccag tacgcgcacg gcaggttcat gaacgcgttg tcccacgtct
    13501 cgaacggggc gatccgcgcc agtcgcgtgt tgtcctcgtc ccaggtacgc cactccgtgg
    13561 gccacggcgc gtcattgcac tcgacggccg tgtacacggc gttgccgttc tcgctctcct
    13621 tggccgcctc cggcaccgga gccgccagtc tgaccagcgg cttcgggtct cccttcagat
    13681 agcgggagag ggcgtgggcg cgcgaggccc agtagtcgtc gtagtacccg gcctggaggt
    13741 aggcgccctg gagctggccg gggcccacgg tgccgcccgc gggtttgcgg gccagcttgt
    13801 ccttggcctt gtcgaagttc ttctgcacat cgtcgaccgt ggtcccgagg tgatacgtcg
    13861 cgtcgtgcga ggcgacccac tcgcggaagt cggtccagcg gttctcgaac gccaccgact
    13921 ggtcgaggtt gttgcggtac cagatctgct ccggatcggg atcgaccgcg gagtcgaaga
    13981 ccatccggcg cacatgaccg gggaagagcg tcgcgtagac cgcgccgaag taggtgccgt
    14041 acgaggcgcc catgaacgtc agccgcttct caccgagccc cgcgcgcagc acgtcgaggt
    14101 cgcgggcgtt gttgagcgtc gtgtactgcc gcagcccctc gcccgccgag cgcccgcagt
    14161 cgcgcgcgta ggccttggcc tgggccaccc gctcggcctt gtaggcctcg tcggggtggg
    14221 tcggggactg ggagggtgcc ttgccgtact ccttcgggtc ctgacaggac agcggcgccg
    14281 agcgtcccac gccacgcggc gcgtagccga cgagatcgta ggagccggcc agcttcttcc
    14341 actcgggaag tgtggagacc agcgggaagt acatgcccga cgcgccgggg ccgcccgggt
    14401 tgaacaccag cgccccctga tggggcgggg ccgccttcgc gcccttcttc ggcttcgccg
    14461 gtttggcccg gctcaccgtc agcttgatct gtctgccgtc cggatccgcg tagtcgaagg
    14521 ggacgctgac ggtgccgcac ttcacgacgg acggcaaccc ctccgacttg gggcaggcgc
    14581 cgaacgcgat gcccttggcc gcggcgcgct cggccgccag cgccgtaccc ctcgcctcgg
    14641 ccacgtgctc gggcggcgtc gaccggccgg aggcgccgcc cgcgggcgcg gccacgaggg
    14701 cggtcagcag cagcgaaccc gcggttccgt agaggagggg ggtgaggggt gctctcatcg
    14761 gtatcccttc gtacgacaga agaataaaag ggatacttgg gttgatagtt gagtaagtaa
    14821 agcaccatta cgccgtgtcg ggcgtccgtt tggatcacgg tgccggcccc cgtggctcgg
    14881 gcgcccatat ggcaaggacc ccttaggtca ctgggctcgc tggggtggcc ttcggcgcgc
    14941 gaaggccgcg ctcagcgccg gatcgcgcag cgcccgcaca ccgcgcacgg cgacagcgac
    15001 gagcgcggcg ccgccttcgc ctgtccgctc ccgcgcgacg aacgcgccga gcagtcgctg
    15061 tcccacgggg gaggcccagc gggtgtacgg atgcacctcg atccgtgcga cgaccaggca
    15121 gccgagggcc agcaccgcgg gcagactgaa ccacgccacg atctccgtgc ccggggtccc
    15181 tggcgcggcg gagggcgaga gcagggcgag tgcggtgagg gcgggcaggg cgagcgcggt
    15241 ccacgccacc tgacgggtcg cggaggccac gttctcacgc gccctgtccg gtacggcgag
    15301 gccggccgtg ttcagccgct cggccagggc ccgcaccgcg tcggacgtgg cgacggcggc
    15361 gcggaccacc gctatcagtt cctggccccg tacgccgagt gcgagcagta ccgcgcgctc
    15421 caggtcgtta cggcccctcg ggtcgaccac tgtcgcccag ccggtgcgcg ccagcagcag
    15481 acgccggccc cgcgccatcg ccacgagggt cacgtcgacg gcgcgcaggg ggccgcccga
    15541 gaggtacgcc gcctcgtgga gcggcagctc gtaggcggcc aggatccggg cgtccgcctc
    15601 gctcacctct acggaggggg cggtctctcc cgccctgatc gccgccaggc agagccgtgc
    15661 gcaggcgaga ccggtggagg cgcaggcgac gaggagcaga gggatccaga gcatggcgga
    15721 gttctacgcc tgaatgacgt gctcgtgcca ggtcccttca cgaagtgagt cgatgcgcga
    15781 ccggtacgcc gtcccacggg tcaccgcacg ccccacctgc cccatgcgta cctgcctctt
    15841 gcgcgtccgt ccctcttctt cgttccttgc gcgctcggtc cggccgaggg ggctcagcgc
    15901 cgcagcagca ccgaacgcgc ggccctggcc agtcgccgca ccgcacccga gggaagtggc
    15961 tcggggccgg accgctccag ccaccacgtg gagagccgtc gccgcgtgct cccgcccgcc
    16021 ggacgtgccg ccgtcagcag gaactcagcg aagtcgagcg cgtccttgcg gtatccgccg
    16081 gtcaggggcc gcgtacgggc gtagtcgagg aaatgggcgc ggtatccgtc gccgaggatc
    16141 tccggcagtt ccggtgcgac cttggcgacg acgtcggcgc gtttcgcggc gagtgcccgg
    16201 ctctgcaccc cgagccgcgc cggatcgaac ccctccggta cgggtcccgc gtcgaccagt
    16261 gccgcaagca gggcgtactg gccgtacccg agccggtcac gggcgccgga gtccgagggc
    16321 ccttcggagg acccggggcc gccgacgacg aagagcgcgc cgtcgccgag ggagccgtca
    16381 cgcgggtcgt cggcgtacgg ggcgggccag tccaccgcgg cggcctccgg cccggcggca
    16441 cccccggccg catacccggc ttcggaccgg gccccggctc cggacccgtc ggcaaagttc
    16501 gcgccctcga caagcggccc cgattccgcg gcctgctcgg tggccgtgcg gggtgcggtg
    16561 gccgggggag ccgcggtcac caccatcacc atgtcctcgg cgggcccggc cgccgccgag
    16621 gtgacgatca ggacctcgtc ctcggccacg tgttccgccg gagcggtggc ggcttcccga
    16681 gccggggtgc tgacgaggac ggactgaccc gatccggccc cggagcgcac ggtggcgcgg
    16741 atggcgtcga gttcgtcctc caactcggcc gggtcgggaa agttctcgtc gcgctcaagc
    16801 agcacaccgg gcggccgggt gcgtgaacag aggtcggcga ggatgccgag tacgggttcg
    16861 gggaccgggt gggcgtggct gtcgtgccag acgccgtcgc gttcgaagcc tccggcgacg
    16921 tggacgtagg cgatggcctc cacggggagt tggctcagcg cggtcgccgg gtcctgaccc
    16981 atgttgacgt ggttggtgtg gaggttggcg acatcgatga ggagccgcac cccggtgcgt
    17041 tccaccagct ctctgaggaa ctgcccctcc gtcagctcct cgtccggcca ggggaacagc
    17101 gcggcgatgt tctccacggc cagtggcacg ggaagcgcgt cctgggcgat gcggacgttc
    17161 tcgcacagca cgtccagcgc gtccctggta cgcggcacgg gcagcaggtg cccggcctcc
    17221 agtgagggtg cggcgatctg cgggccgccc gccctgacga acgcgatgtg ctcggtcacc
    17281 agcggcgatt cgagggccag cgcccgttcg gcgagggcgg cgagccgttc gggatcgggc
    17341 cggtcggcac caccgagacc gagccccacc ccgtgcggga cgacggtcac accgcgctcg
    17401 cgcagccgca cgagggagtc cggcaggtga ccggggcaga gattctccgc gacggcctcg
    17461 acccagtcga cccccggcat acgctccacc gccgaggcga tctccggtcg ccagccgatc
    17521 cccgtaccca actgcccgtg atattccatg tcccctccgt ccaccgtgcc ctgccccgtg
    17581 cggcgccctt cgggggttca tcgccacgca acggggatcc gaacccctga acagagacgt
    17641 tcagaggtcg atttgaggtt cctgccgggc cctgctcccg gccgtcggcc atccctcggc
    17701 ggtgagaaca cgggccatcg gcacccaccg aggaccgtct gcgacggggc cgttggcctg
    17761 cggtgacgcg gcttcgggcg acacggccaa ggacgaggcc acagggcgtg gacgcgcacg
    17821 tacacgaggg cgggtgcttc ggttcggctc gcggtgcgcc cgcgcagcgc cggggtcggg
    17881 gccggaacac agccgcgcgg cagaggccgc ggtcctggcg ttcagccccg gtcctcgccg
    17941 tctccgggct cggtacaggt cggcccgtac ggcggcgatg tcccctaccg gcccggtgac
    18001 ggggtcctgg gtgaacgccg tcatccgcag ccgcccccca ccggtggtga ggacaagcca
    18061 cccgccggtg gtgacgacag ccgaccgccg gcggtgacga gagccgaccg ccggcggtga
    18121 cgatgtcgag tacgtgtccc ccatgtggcc ggggggtccg cgtcgagagc cccatcggga
    18181 tgtcaggagc gcttggcggg cagcagaccg atggccgcaa gccgcttgtt cgagctacgg
    18241 gcggcccagg cgaccaccaa gagggcgagg gcgagcagcg ggaagcccat ggcgatcttg
    18301 gcgaatccca gcgaaccgac ctggtcggtc gcgtagaagt actgctggac ggcgaaccgg
    18361 gcgccgaaga ccgcggccag caccagggtg gcgatgtcgt agtagagccg cgaacgcttg
    18421 tccgcgcgcc agacgttgcc cttgccggtc gccacgttcc agatcacgcc ggccatcggc
    18481 caccgcgcca ggacggagag gaggaagagg acggcgccgg ccaggctcgc ccagattccg
    18541 atgaggaagt agtccttggc ggagccggtc aaccagacga cgcctgcggc tatcgcgacg
    18601 ccgaacacgc cgccgatcgc gggttgtacc gattccttgc gcagcaggcg ctccacgccg
    18661 atggcgaccg cgacggcgag ggcggcgatg acggccatcc gtagtccgcc gacgctgttg
    18721 gcgacgacga acgccaccac gggcagtgcc gagtagacga cccccttggt gcctccggcc
    18781 tggtcgagga ccgaaggccg ttgccggggt gctgtctgct ccgtccgctc cacctgcgtg
    18841 tcggactctg tctccaggaa gctcacggtc ttcatggtgg tcacttctcc cgagttcgtc
    18901 ttgggggcga gctgcgatgt cactgtgtcg cttagcgcca gtttgacatt tagtgacacg
    18961 gtgacgctac caccccatgg tgtgacgtgc atcacattgc gctgtccgtt tggcgtgagc
    19021 cacccccggg cgaggtgctc gcaccccttc tgctccgaac cgtggattcc agtcgccgtc
    19081 acgcctgttc gggcatccgg ggtttcttga gcgagcttga ggtagctgtc acttagtggc
    19141 agtgtcacta agtgacaggc gggcctctgg cctcgcctcc cttacgacat cgggcactga
    19201 ccacaggagg actgacatgg caccgcggga gaccatctcc gtcgaggagt tcttcgggcc
    19261 gccgcttcgc gcgaagacga ccctctcgcc ggacggcagg aaaatggcgt atctggcgct
    19321 gtgggagaac cgcctgaacg tctggataga gagcgtcgac acgccggggg actcgcgatg
    19381 cgtgaccacg gaggaccgtg gggtcctgag ctaccactgg acccgggacc cgcggtggct
    19441 gctctacacc cgggaccagg gcggcgacga gaacatgcac ctctaccgcg tcgacctgga
    19501 ggacccggac gccgccgccg tgaatctcac gccctatccc ggggttcgga ccttgggcct
    19561 tgacctcccc gccggacgtc cgggcaaggt catcacccaa ctgaacctgc gcgaccgcgc
    19621 ccagttcgac ctggtggaac tggacatcgc caccggcgac ctcacgactc tcgccaagaa
    19681 cccggggagc gaagtggagg ggtggctgta cagcgagcga gatctgttcg cgggagggac
    19741 gacggccgag ggcgatgtcc tgctgtccaa gtgggacgcg gcgaccggtg cgctggaccc
    19801 cgtggcgcgg ttcgacggcg gtgacgctcc gctggggatc taccccttgg aggtcacacc
    19861 ggacggcggc ggggtgtggc tgggctcgta ccgagggggc gaccgcctcc gcctggcccg
    19921 actcgacctg gcgaccggcg aggaggagga ggtcgactcc catccgcggt acgacctgga
    19981 cacccgcgca caggtctttc ccgccctgcc gtcccctctg atccgcagcc gccgcacagg
    20041 cgaactgctg ggagtccgct acctcgggga gcggcaggtg atccacgccc tggacccgca
    20101 tttcgccgcg gtgctgaaga atctggagaa gctgtccgac ggcgatctcg ccggactctc
    20161 ctcagacgag agcggccagc ggtgggtggc cggcttcacc cacgaccgtg accccggggc
    20221 caccttcctc tacgaccaca ccaccggcga gagccgtctg ctccaccggg ccaggccgca
    20281 cctggatccg gagtcgctcg caccgatgcg cccggtggag atcacctcca gggacggtct
    20341 gacgctgccg tcgtacctga cgctgccggt cggcatcgag ccgtcccggc tgccgctggt
    20401 gctgttcgtc cacggcggtc cctggagccg ggacagctgg gggtaccacc ctgccgcgca
    20461 gctcttcgcc aaccgcggtt acgcggtgct acaggtcaat ttccggggct ccaccggata
    20521 cggcagggcc ttcaccaggg ccgccatcgg ggagttcgcc ggcaagatgc acgacgacct
    20581 catcgacggt gtgcgctggg cggtcgagcg gggatacgcc gacccggacc gcgtggccat
    20641 catgggcggc tcctacggcg ggtacgcgtc actggccggg gtcaccttca cgccggacgt
    20701 cttcgccgcc gctgtcgatg tcgtcggtat ctcggacctg gccaacttca tgcggagcca
    20761 gcccgacttc gtcaaaccga tgctcaccca caactggttc acatacgtcg gtgacccggc
    20821 cgatcctgag caggaggccg acatgctggc ccgctccccg atcacccgtg tcgaccaaat
    20881 ccgcaccccg ctgatggtgg tgcacggcgc caacgacgcc cgcgtcgtcc tcgccgagtc
    20941 cgacctgctc gtcgaggccc tgcgcgcacg aggcgtcccc gtcgagtaca ccgtcatgcg
    21001 ggacgaaggc cacgccatcg agaacccgga gaacgtgatc gccctctaca ccggggtgga
    21061 acgcttcctg gccgaacacc tgggcttcga ggcccgctcc taggggcgga gggcggggag
    21121 agcgcgcggc ctcatacccc gggccacctg aggccgcgcc cccttcgtgc ccctcggtca
    21181 cagcggcggc ccccttggcc gcggcggcgg ccgctcccgg ctcagagcct cacagcacgg
    21241 cgtgccggcc ggcttccgtg tgcgtgtgcg tgtcctggtg catgtccagg aatgtgcgcg
    21301 ctcacttgcc gcacgcgtcg ccgatcatcc ctcgcgcaac gccgggtgat cggcgatcac
    21361 cgtgcaggag ccgggggcga tctcggtgaa ccccgcgtcc tggaccaccg gcagcccgct
    21421 cgtcacgagc gtgcgccagt gggccggggc cgccgtgcgg acggccagcg ggaagcccgc
    21481 ttcgcgccac gcgtcgcgct cggcgggtga cagctcccac cacgccaact gggcggcgtg
    21541 acccgcctga gccatggcct tgcccgcgga catcgtgacg tccggactca tccacagcac
    21601 cgggacgccg gggtcgggcg ccgacggtgg ttcagggtcg tccagttccg tacctgacac
    21661 ctggagcttc gccaggtcct tcggccagcc gtcgacgggg atcggcggga agacccgcac
    21721 ctcggcggcc ttccccgtga gggtgatccc cggcatcgtc ccggtccgcc gccactccgc
    21781 gccgcgcgcc cgccgcacca ccttgcggat tctggcgtcc tgccagtccc gcacggcctc
    21841 ggcccactcg ccgtcgccca ccgaccgctc gtcggagagc agagcgagta ccgcccgtgc
    21901 cgccgtctcc atcgcgtccg tacgggccgg gggatctgcc cgctccagcc ggaccaccaa
    21961 gggcaggacg aactggggcg cctcgtcccg ctcggtcggt tcgttcacga acgggctgtc
    22021 ctgggtgtcc gctccccgga cacgaccggg tccgggttcg ggggcaccgc cctcggccgc
    22081 ccccggggtg gtgtcggccg gggcggaagg agaggtctgg acgccgtcgg ccggcgtgct
    22141 ggggatgtcg tcgctgctca cccggccagt ctgccagcac gcctggccac agcccttggc
    22201 gatgtccgac cggcacgcca ggatggcacg tatgaaaagc gacctcttcg cgaccaagaa
    22261 catggcccag ccgcccgccg cggccgggat gaccttgcag aacgcaaagt cgatcaagta
    22321 caccgtcaac ggtgagatgt acgccaggca gggagcgatg gtcgctttcc gcggcaatct
    22381 ccagttcgag cgcaagggcc agggcatcgg cggcatgttg aaacgggccg tcaccggcga
    22441 ggggctgccg ctgatgtccg tgagcggcca gggcgaggca tggttcgcgc acgaggccgc
    22501 caactgcttc atcgtggacc tggagggcaa cgacccgctc accgtcaacg gccgcaatgt
    22561 cctctgtttc gacccctccc tcggttatga gatcaaggtc gtgaagggcg cgggaatcgc
    22621 cggaggcggg ctcttcaaca gtgtcttcac cggccacggg aagctcggac tggtctgcga
    22681 gggcgagccc atcgtgatcc ccgtggcgac ccaggcgccc gtgtacg
//
