LOCUS       NZ_CP045178            21173 bp    DNA     linear   CON 25-NOV-2024
DEFINITION  Streptomyces tsukubensis strain AT3 chromosome, complete genome.
ACCESSION   NZ_CP045178
VERSION     NZ_CP045178.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces tsukubensis
  ORGANISM  Streptomyces tsukubensis
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8615214)
  AUTHORS   Cao,G., Zhong,C., Fu,J., Zhang,P., Liu,M. and Zong,G.
  TITLE     Complete genome sequence of Streptomyces tsukubaensis AT3
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8615214)
  AUTHORS   Cao,G., Zhong,C., Fu,J., Zhang,P., Liu,M. and Zong,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-OCT-2019) Shandong Medicinal Biotechnology Center,
            Shandong First Medical University, 18877 Jinshi Road, Jinan 250062,
            China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 01-OCT-2019
            Assembly Method :: SOAPdenovo v. OCT-2019; SPAdes v. OCT-2019
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 997.0x
            Sequencing Technology             :: Illumina HiSeq; PacBio RSII
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_009296025.1-RS_2024_11_20
            Annotation Date                   :: 11/20/2024 08:40:01
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,005
            CDSs (total)                      :: 6,919
            Genes (coding)                    :: 6,691
            CDSs (with protein)               :: 6,691
            Genes (RNA)                       :: 86
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 65
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 228
            CDSs (without protein)            :: 228
            Pseudo Genes (ambiguous residues) :: 0 of 228
            Pseudo Genes (frameshifted)       :: 76 of 228
            Pseudo Genes (incomplete)         :: 184 of 228
            Pseudo Genes (internal stop)      :: 10 of 228
            Pseudo Genes (multiple problems)  :: 38 of 228
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 05:10:03
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5817291
            Orig. end                         :: 5838464
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP045178.1.
            Bacteria and source DNA available from Dr. Guangxiang Cao.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21173
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="22"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21173
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21173
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11173](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11173
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(296..619)
                     /locus_tag="GBW32_RS24710"
                     /old_locus_tag="GBW32_24700"
     CDS             complement(296..619)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018845570.1"
                     /locus_tag="GBW32_RS24710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_24700"
                     /product="multidrug efflux SMR transporter"
                     /protein_id="WP_077966091.1"
                     /transl_table=11
                     /translation="MAWLLVIVAGLLETGFAVCLKLSHGFTRLWPTIAFASFALGSFGL
                     LTLALRKLDVGPAYAVWTGIGAAGTAIYGMIFLDDVVSVLKIVSISLVVMGVIGLQLSG
                     SAH"
     gene            complement(732..1754)
                     /gene="rsgA"
                     /locus_tag="GBW32_RS24715"
                     /old_locus_tag="GBW32_24705"
     CDS             complement(732..1754)
                     /GO_function="GO:0003924 - GTPase activity [Evidence IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /GO_function="GO:0043022 - ribosome binding [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /gene="rsgA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003966421.1"
                     /locus_tag="GBW32_RS24715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_24705"
                     /product="ribosome small subunit-dependent GTPase A"
                     /protein_id="WP_077966089.1"
                     /transl_table=11
                     /translation="MRRYGKNPDEDDIRVRPNTKGNRPRTHTRPKHEDASWGMVLTVDR
                     GRITCLVEDRTIMAMKARELGRKAAVVGDRVALVGDLSGKKDTLARIVRIEERGSVLRR
                     TADDDDPYERVVVANADQLAIVTALADPEPRPRMIDRCLVAAYDGGLEPLLVLTKSDLA
                     SADKLLETYRPLGVPYVVTSRDELYEGRAADRVRDLLDGRVTAFVGHSGVGKTTLVNAL
                     VAQDRQRSTGHVNAVTGRGRHTTVSALALPLPEGGGRRGGWVVDTPGVRSFGLHHVEPS
                     RVIKAFPDLEPGTENCPRGCTHDEPECALDAWVEEGHADPARLYSLRRLLASRERREGD
                     "
     gene            complement(1772..3112)
                     /gene="aroA"
                     /locus_tag="GBW32_RS24720"
                     /old_locus_tag="GBW32_24710"
     CDS             complement(1772..3112)
                     /EC_number="2.5.1.19"
                     /GO_function="GO:0003866 - 3-phosphoshikimate
                     1-carboxyvinyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0009073 - aromatic amino acid family
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="aroA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010984472.1"
                     /locus_tag="GBW32_RS24720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_24710"
                     /product="3-phosphoshikimate 1-carboxyvinyltransferase"
                     /protein_id="WP_077966088.1"
                     /transl_table=11
                     /translation="MTENPALTALWPAPHASGPVTATVQVPGSKSVTNRGLVLAALAAE
                     PGWLRRPLRSRDTLLMAGALRAMGVGIEETVPSSSPTASGAGSAGEAWRVIPAGLHGPA
                     TVDVGNAGTVMRFLPPVATLADGPIRFDGDPRSYERPLHGVIDGLTALGARIDDGGRGS
                     LPLTVHGCGALDGGSVEIDASSSSQFVSALLLSGPRFNQGVEVRHVGSALPSMPHIRMT
                     VDMLRRVGAQVDEPETGGEPNVWRVSPSAMLGRDLTVEPDLSNAQPFLAAALITGGRVT
                     IPDWPARTTQPGDRLREIFTEMGGSCELTDEGLVFTGSGAVHGIDVDLSEVGELTPGIA
                     AVAALADSESVLRGVAHLRLHETDRLAALTKEINELGGDVTESADGLVIRPRPLHGGTF
                     HTYDDHRMATAGAILGLAVKGVTIENVGTTAKTLPDFPDLWAGMLGN"
     gene            complement(3285..3998)
                     /locus_tag="GBW32_RS24725"
                     /old_locus_tag="GBW32_24715"
     CDS             complement(3285..3998)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003992842.1"
                     /locus_tag="GBW32_RS24725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_24715"
                     /product="M50 family metallopeptidase"
                     /protein_id="WP_077966087.1"
                     /transl_table=11
                     /translation="MDSTNLADLWDRVFGSQPDPDQWLVFGTGLVALAAIVPHGIWRLS
                     RNAITIAHEGGHGLVALLSGRRLDGIRLHSDTSGLTVSRGRPTGPGMVLTAAAGYTAPP
                     LIGLGGAWLLAANHITLLLWAATVLLLLMLLMIRNAYGALTMIVTGGAFVLVSWLTGPQ
                     VQAAFAYVVVWFLLLGGVRPAFELQTKRRRGGAGDSDADQLARLTGVPTGPWFLFFHVV
                     SLGCLAVGGRWLLGL"
     gene            4048..4893
                     /locus_tag="GBW32_RS24730"
                     /old_locus_tag="GBW32_24720"
     CDS             4048..4893
                     /EC_number="3.4.-.-"
                     /GO_function="GO:0003697 - single-stranded DNA binding
                     [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_process="GO:0009432 - SOS response [Evidence IEA]"
                     /GO_process="GO:0018142 - obsolete protein-DNA covalent
                     cross-linking [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019980380.1"
                     /locus_tag="GBW32_RS24730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_24720"
                     /product="SOS response-associated peptidase"
                     /protein_id="WP_077966086.1"
                     /transl_table=11
                     /translation="MCGRFAASRGAEDLAGIFGIEKWEPAETLAPDWNVAPTKQVQVVL
                     ERPLKHAAADPDTDKDAGGGRPVRQLRTLKWGLVPSWSKTPEGGARMINARAETVHEKP
                     SFRRAFATRRCLLPADGYYEWVTGTEERELEETGRKKRPRKQPYFVTPADGSVFAMAGL
                     YEFWRDRTLPDDHPGAWWVTCSVITTEAEKEPLAVAPEEGPRALADIHPRMPLMLTPDR
                     WDAWLDPSWTEPDDLLPLLAPPPGGLLRAFPVATAVSNVRNNGPELLKELEGPEEATLF
                     "
     misc_feature    4994..5013
                     /note="TFBS match to DosR, Hypoxia stress response
                     regulator, confidence: weak, score: 23.23"
                     /tool="antismash"
     gene            5065..5733
                     /locus_tag="GBW32_RS24735"
                     /old_locus_tag="GBW32_24725"
     CDS             5065..5733
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020136689.1"
                     /locus_tag="GBW32_RS24735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_24725"
                     /product="alpha/beta family hydrolase"
                     /protein_id="WP_077966085.1"
                     /transl_table=11
                     /translation="MGPVTSAKSSETVDTPAGEARITWHPAKAARLVLAVSHGAGGGIE
                     ARDLRALAAVLPEHAVSVALVEQPWRVAGKKLAPAPKTLDVGWRGVWPALQGPGLPVIA
                     GGRSAGARVACRTAKELGAHAVLALSFPLHPPGRPEKSRADELLGAGVPVLVVQGGNDP
                     FGKPAEFPVEVVGAGGGAHELVEVAGGDHGFAVPKRGALGQDDAVRIITDAVRDWTARL
                     "
     gene            6256..6921
                     /locus_tag="GBW32_RS24740"
                     /old_locus_tag="GBW32_24730"
     CDS             6256..6921
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973756.1"
                     /locus_tag="GBW32_RS24740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_24730"
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="WP_179120096.1"
                     /transl_table=11
                     /translation="MGRVTGTDAGTDHSQAEQPEETTAERNARFERDALSFLDQMYSAA
                     LRMTRNPADAEDLVQETYAKAYGSFHQFREGTNLKAWLYRILTNTFINSYRKKQREPQR
                     SAAEEIEDWQLARAESHMSTGLRSAESQALDHLPDSDVKSALQAIPEEFRIAVYLADVE
                     GFAYKEIADIMGTPIGTVMSRLHRGRRQLRGMLEDYARDRGLVPAGAVQSDDLKGSGS"
     gene            6918..7262
                     /gene="rsrA"
                     /locus_tag="GBW32_RS24745"
                     /old_locus_tag="GBW32_24735"
     CDS             6918..7262
                     /GO_function="GO:0016989 - sigma factor antagonist activity
                     [Evidence IEA]"
                     /GO_process="GO:0045454 - cell redox homeostasis [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="rsrA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014154163.1"
                     /locus_tag="GBW32_RS24745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_24735"
                     /product="mycothiol system anti-sigma-R factor"
                     /protein_id="WP_077966083.1"
                     /transl_table=11
                     /translation="MSCGEPHETDCSEVLDHLYELLDHEIPDSDCTKYEDHFQECSPCL
                     EKYGLEQAVKKLVKRCCGQDDVPADLRAKVLGRIDLIRSGQAVPEQDITVARPETADTA
                     GRVPGHLTES"
     gene            7775..8755
                     /locus_tag="GBW32_RS24750"
                     /old_locus_tag="GBW32_24740"
     CDS             7775..8755
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019889310.1"
                     /locus_tag="GBW32_RS24750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_24740"
                     /product="hypothetical protein"
                     /protein_id="WP_077966512.1"
                     /transl_table=11
                     /translation="MRIFGKGRHRPSASWRQATDRAFTLIGDGRYEDAGALLTRAADLE
                     PWLSESWFNLALLHKFRHDWEQARAAGLRAVALLDRGAGAPDWWNVGIAATALQDWALA
                     RRAWQAYGLRVPGSAVDTDEPSGMELGSAALRLSPEGEAEVVWGRRLDPARVEVLSVPL
                     PSSGRRWGEVVLHDGVPNGERTTADGQGYPVFDEIELWAPSPVPTWVVLLEAAGEDDRD
                     ALVELAAEAGFAAEDWSSSVRLLCRMCSESRMPSDEGDGEHLDPHDHSEPGHPGPLGHR
                     SPGELWVPERECGIAAPSSLVRGLLDGWVADSPDSRDWRDLEEVC"
     gene            8978..9637
                     /gene="def"
                     /locus_tag="GBW32_RS24755"
                     /old_locus_tag="GBW32_24745"
     CDS             8978..9637
                     /EC_number="3.5.1.88"
                     /GO_function="GO:0042586 - peptide deformylase activity
                     [Evidence IEA]"
                     /GO_process="GO:0036211 - protein modification process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="def"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1275: peptide deformylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017236275.1"
                     /locus_tag="GBW32_RS24755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_24745"
                     /product="peptide deformylase"
                     /protein_id="WP_077966082.1"
                     /transl_table=11
                     /translation="MAQQDTEHEQAQDEGVLPVDDEGFVIDTEDAGEREEARCARGTAR
                     PITVVGNPVLHKECRDVTVFDEELDRLIDDMFASQRAAEGVGLAANQIGVDLKVFVYDC
                     GDDEGVRHVGAVCNPVLRELPADQRRLDDSNEGCLSVPTAYAETPRTDYAEVTGQDARG
                     NPVRIRGNGYFARCLQHETDHLYGYLYIDRLSKRDRKDALRQMAEGTARYATVPNA"
     misc_feature    9805..9818
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.71"
                     /tool="antismash"
     gene            10001..11173
                     /locus_tag="GBW32_RS24760"
                     /old_locus_tag="GBW32_24750"
     CDS             10001..11173
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004925880.1"
                     /locus_tag="GBW32_RS24760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_24750"
                     /product="terpene synthase family protein"
                     /protein_id="WP_227025281.1"
                     /sec_met_domain="T1TS (E-value: 3e-59, bitscore: 200.2,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPAYPHSTSSSTSSVPSTLALPVVEADFPRRLHEFWPKLQEKSKA
                     WLLEKRLMEPDLAELHADGLRYTDLVAGYYLGAPDTILASIADLSVWFFVWDDRHDRDT
                     VHGRGRSWFALTADLRTALVAPRSHLHHEEPLVAAFADCVQRLTQPLGRGWRDRFVAHF
                     ADVIDSYDEEFRNRAVGEVPTVDTYVKLRRRTFGHEVWLDLLELAAVRELPEHIRENEA
                     YRRAGMATQDFSAWYNDLCSLPKELAGDEVHNLGISLIQHQGLSLEEAVSEVRRRVSGC
                     VTEFLFIEKDVVALADAAAAEGTFAGVELRSAVLACLDNMRNWFSSVYWFHHESGRYRV
                     ESWSDRSHPPYVSDHLPGGGQEPAAPPAGPRGQRWRRRRASAENKKTGDA"
     misc_feature    complement(10004..10022)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 20.77"
                     /tool="antismash"
     gene            11170..12531
                     /locus_tag="GBW32_RS24765"
                     /old_locus_tag="GBW32_24755"
     CDS             11170..12531
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016644064.1"
                     /locus_tag="GBW32_RS24765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_24755"
                     /product="cytochrome P450"
                     /protein_id="WP_077966080.1"
                     /sec_met_domain="p450 (E-value: 1.7e-75, bitscore: 253.2,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTRATASAAGRERDAPPLVSGALPLVGHGLSLVRGPLAFLETLR
                     DHGELVRIKLGPRTAYAVCAPELVGTLLKSPDYAVGGPLWETLEVLLGKGVATSNGAVH
                     RRQRRAIQPAFRTERIPEYAVVMREEACRTADRWQEGRTVDVGAEMFRTGVRIVSRSLL
                     EGDSIGEKADRISESLHTVFSGLYQRMILSFGPLHRLPTPANRRFARALADLHSVITEI
                     IRERRESAIESDDLLAVLLATKDGDGKPLSEQEVHDNVVSLVVAAAENVAATLAWTFEL
                     LTEHPGHESRLFQEVESVAPGRPVDFDDLQNLPYTRNLIMEAMRIRPAAWIFTRRAVAD
                     TELGGYRIPAGSDIVYSAYAMQRDPRSFEQPHEFDPDRWLPERAASVPPFAMMPFGVGN
                     RKCPGDHYSLAQVALVLANIVRGWHLSTVPETDGNPRIGITLQPKRLLLRPERR"
     gene            complement(12632..13690)
                     /locus_tag="GBW32_RS24770"
                     /old_locus_tag="GBW32_24760"
     CDS             complement(12632..13690)
                     /EC_number="1.17.4.1"
                     /GO_component="GO:0005971 - ribonucleoside-diphosphate
                     reductase complex [Evidence IEA]"
                     /GO_function="GO:0004748 - ribonucleoside-diphosphate
                     reductase activity, thioredoxin disulfide as acceptor
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006260 - DNA replication [Evidence IEA]"
                     /GO_process="GO:0009263 - deoxyribonucleotide biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003992855.1"
                     /locus_tag="GBW32_RS24770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_24760"
                     /product="ribonucleotide-diphosphate reductase subunit
                     beta"
                     /protein_id="WP_077966078.1"
                     /transl_table=11
                     /translation="MTTAENTTTAHSADPKAAAEKNLLDPGFELTLRPMRYPDFYERYR
                     DAIKNTWTVEEVDLHSDVTDLAKLSPEEQHMIGRLVAFFATGDSIVSNNLVLTLYKHIN
                     SPEARLYLSRQLFEEAVHVQFYLTLLDTYLPDPDDRAAAFAAVENIPSIREKAEFCFRW
                     MDSVDQLDRLESKADRRLFLLNLICFAACIEGLFFYGAFAYVYWFRSRGLLHGLATGTN
                     WVFRDETMHMSFAFDVVDTVRKEEPDLFDDALEQQVTDMLKEAVASELQFAQDLCGEGL
                     PGMNTDSMREYLECVADQRLQRLGFAPLYGSSNPFSFMELQGVQELTNFFERRPSAYQV
                     AVEGSVSFDDEF"
     gene            complement(13690..16074)
                     /locus_tag="GBW32_RS24775"
                     /old_locus_tag="GBW32_24765"
     CDS             complement(13690..16074)
                     /EC_number="1.17.4.1"
                     /GO_component="GO:0005971 - ribonucleoside-diphosphate
                     reductase complex [Evidence IEA]"
                     /GO_function="GO:0004748 - ribonucleoside-diphosphate
                     reductase activity, thioredoxin disulfide as acceptor
                     [Evidence IEA]"
                     /GO_process="GO:0009265 - 2'-deoxyribonucleotide
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009068626.1"
                     /locus_tag="GBW32_RS24775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_24765"
                     /product="ribonucleoside-diphosphate reductase subunit
                     alpha"
                     /protein_id="WP_077966076.1"
                     /transl_table=11
                     /translation="MTIAPADPVSAFQTESDLPGTALLRTLTELTVDLPDTDPGRVAAA
                     ALRGRGAASDEAELRGLATEAAAGLISEDPAYSRLAARLLTISIAEEAAAQGVRSFSES
                     VATGHREGLIADRTAAFVSLHAARLDALIDTGADDRFGYFGLRTLYSRYLLRHPITRGV
                     VETPQHFMLRVAAGLAADESVDAVDEVASLYGLMSRLDYLPSSPTLFNSGTRHPQMSSC
                     YLLESPLDELDSIYDRYREVARLSKHAGGIGLSYSRIRSRGSLIRGTNGHSNGIVPFLK
                     TLDASVAAVNQGGRRKGAAAVYLETWHSDIEEFLELRDNTGEDARRTHNLNLAHWIPDE
                     FMRRVAADQEWSLFSPSDVPDLVDLWGDEFDASYRAAEAAGLAKRTIPARELYGRMMRA
                     LAQTGNGWMTFKDASNRTANQTAEPGHTVHSSNLCTEILEVTNDGETAVCNLGSVNLGA
                     FVDGHTMDWARLDETVHTAVTFLDRVVDINFYPTEQAGRSNAKWRPVGLGVMGLQDVFF
                     KLGLPFDSAEAKALSTRIAERIMLAAYEASADLAEKNGPLPAWEKTRTARGVLHPDHYD
                     VELTWPERWSALRARIASVGMRNSLLLAIAPTATIASIAGVYECVEPQVSNLFKRETLS
                     GEFLQVNTYLVRELKRLGVWDARTREALRESSGSVAGFHWIPQEVRDLYRTAWEIPQRG
                     LIDMAARRTAFLDQSQSLNLFMETPTIGKLSSMYAYAWQQGLKTTYYLRSRPATRIARA
                     AGSAEAATAPSPATVPTQQPAPDADAIACSLENPESCEACQ"
     regulatory      complement(16210..16351)
                     /bound_moiety="adenosylcobalamin"
                     /db_xref="RFAM:RF00174"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00174"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="cobalamin riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     misc_feature    complement(16331..16345)
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: medium, score: 22.83"
                     /tool="antismash"
     misc_feature    complement(16363..16377)
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: medium, score: 22.2"
                     /tool="antismash"
     gene            complement(16640..18274)
                     /gene="mctP"
                     /locus_tag="GBW32_RS24780"
                     /old_locus_tag="GBW32_24770"
     CDS             complement(16640..18274)
                     /GO_function="GO:0015293 - symporter activity [Evidence
                     IEA]"
                     /GO_process="GO:0006848 - pyruvate transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="mctP"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018521030.1"
                     /locus_tag="GBW32_RS24780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_24770"
                     /product="monocarboxylate uptake permease MctP"
                     /protein_id="WP_077966074.1"
                     /transl_table=11
                     /translation="MNDGVNGVALAVFIFFFVAVTVMGFMAARWRRADNEATLDEWGLG
                     GRSFGTWVTWFLLGGDLYTAYTFVAVPAAIYAAGASGFFAVPYTILVYPLIFTFLPRLW
                     SVSHKHGYVTTSDFVRGRFGSKGLSLAVAVTGILATMPYIALQLVGIQAVLDVMGIGGG
                     ENTNWFIKDLPLLIAFAVLAAYTYSSGLRAPALIAFVKDGLIYLVILVAIIYIPIKLGG
                     FDDIFAAASKKFETINPATDKPVGALAPGSEATWAYATLAVGSALALFMYPHSITATLS
                     SRSRNVIRRNTTILPLYSLMLGLLGILGFMAIAAGVKVSNGQLAIPQLFENMFPDWFTG
                     VAFAAIGIGALVPAAIMSIAAANLFTRNIYKDFIKPNATPAQEYKVSKLVSLLVKVGAL
                     IFVLGMDKTVAINFQLLGGIWILQTMPSLVGGLFTRWLHRWALLAGWAVGMVYGTWAAY
                     GVASPTQDHFGGSNKLIPGIGQMGYIGMTAFVLNVVVTLVLTVVLRALKAPQGVDETAR
                     SDYTADVGDPGVETELPPATAGTPAGH"
     gene            complement(18271..18564)
                     /locus_tag="GBW32_RS24785"
                     /old_locus_tag="GBW32_24775"
     CDS             complement(18271..18564)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007822222.1"
                     /locus_tag="GBW32_RS24785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_24775"
                     /product="DUF3311 domain-containing protein"
                     /protein_id="WP_077966072.1"
                     /transl_table=11
                     /translation="MAREEEPASGTGGGSGPQRPVVTPVRVVIGLCLVAPFVAMLWVSS
                     YAKVDPAFIGIPFFYWYQMLWVFISSALTMTAYKLWQRDQRTRGAAREGAHQ"
     gene            complement(18924..19712)
                     /locus_tag="GBW32_RS24790"
                     /old_locus_tag="GBW32_24780"
     CDS             complement(18924..19712)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1136: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007458216.1"
                     /locus_tag="GBW32_RS24790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_24780"
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_077966070.1"
                     /transl_table=11
                     /translation="MATDGGSSETGVGVSPVADPGVATRTARVPKYYRLKRHLLDMTQT
                     MPPGTPVPPERTLASEFDTSRTTVRQALQELVVEGRLERIQGKGTFVAKPKVFQALQLT
                     SYTEDMRAQGLEPTSQLLDIGYVTADDTLAGLLDITTGGRVLRIERLRLASGEPMAIET
                     THLSAKRFPALRRSLVKYSSLYTALAEVYDVRLAEAEETIETSLATPREAGLLGTDVGL
                     PMLMLSRHSVDGRGEPVEWVRSVYRGDRYKFLARLKRPVD"
     misc_feature    complement(19870..19885)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 20.28"
                     /tool="antismash"
     misc_feature    complement(19895..19910)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: strong, score: 24.29"
                     /tool="antismash"
     misc_feature    21031..21040
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.07"
                     /tool="antismash"
ORIGIN
        1 gtccccccgg cgggcccggc cgccgacgcc cggtcccacc cagctcatga cgtcggtccg
       61 ggacagggcg gtggcggcgc tcggcaagga gttcccgcag gaggacccgg aggaactctc
      121 ccggcgcagc gagacggccc tgcggctcgc gctctcctat gtcgtggcgc ctgacggcga
      181 aggggcggac tccgtggagt gcgtacgctc cgcgctcacc tcggacggcg gagcacgggg
      241 ggatctgccc gtctcgtgac ggccgtcgcg tcaggggaga gcgcgcggcc cggactcagt
      301 gggcggagcc cgagagctgg agtccgatca cacccatcac gaccagggag atcgagacga
      361 tcttgaggac ggagaccacg tcgtccagga agatcattcc gtagatcgcg gtgcccgcgg
      421 cgccgatgcc cgtccagacc gcgtaggcgg ggcccacgtc gagcttgcgc agagcgaggg
      481 tcagcagccc gaagctgccg agcgcgaagc tcgcgaaagc gatcgtgggc cagagtctgg
      541 tgaagccgtg cgagagcttc agacagaccg cgaaaccggt ctccagaagc ccggcgacga
      601 tgaccagcag ccacgccatg tgttgcctcc cctgtcttcc ctgcctcgtg accactcgtc
      661 agggccgccc tcggcggccc tggtgtgatt atgcctttgc caggccgggt gggccgcaaa
      721 cccgaccggt gtcagtcccc ctcgcgtcgc tcccggctcg cgaggagcct gcgcagcgag
      781 tacagccggg cgggatcggc gtgcccctcc tcgacccagg cgtccagcgc gcactcgggc
      841 tcgtcatgag tgcagccgcg ggggcagttc tccgtccccg gctccaggtc ggggaaggcc
      901 ttgatgaccc gggacggctc cacgtggtgg agcccgaagg aacggacacc cggagtgtcg
      961 accacccagc cgccacgccg gcccccaccc tcgggcagcg gaagggcgag cgcggagacg
     1021 gtggtgtgcc tgccgcgccc cgtcaccgcg ttcacatgtc ccgtcgagcg ctgcctgtcc
     1081 tgcgccacca gcgcgttgac cagcgtcgtc ttgcccacgc ccgagtgccc gacgaaggcc
     1141 gtgaccctgc cgtcgagcag atcgcgcacc cggtcggccg cacggccctc gtacagctcg
     1201 tcgcggctgg tcacgacata cggcacacct aggggccggt aggtctccag cagcttgtcg
     1261 gcggaggcca ggtcggactt ggtgaggacc agcagaggtt cgagaccgcc gtcgtacgcg
     1321 gccaccagac agcggtcgat catccggggg cgcggctcgg ggtcggcgag cgcggtgacg
     1381 atcgccaact ggtcggcgtt ggccaccacc acccgttcgt acgggtcgtc gtcgtcggcg
     1441 gtgcggcgca gtacagagcc gcgctcctcg atgcgcacga tcctggccag ggtgtccttc
     1501 ttgcccgaga gatcgccgac aagggcgacc ctgtcaccga cgaccgcggc cttgcggccc
     1561 agctcacggg ccttcatcgc catgatggtc ctgtcctcga caaggcaggt gatccggccc
     1621 ctgtcgacgg tcagcaccat gccccacgag gcatcctcgt gtttggggcg ggtgtgggta
     1681 cgggggcggt tgcccttggt gttggggcgg acgcggatgt cgtcctcgtc ggggttcttt
     1741 ccgtagcggc gcatggcgtc agtcctggcc gtcagttccc gagcattccg gcccacaggt
     1801 cggggaagtc gggcagggtc ttggcagtgg tccccacatt ctcgatggtg acgcccttga
     1861 ccgcgagacc gaggatcgca ccggccgtgg ccatccggtg gtcgtcgtag gtgtggaagg
     1921 tcccgccgtg cagcgggcgc ggacggatca ccagaccgtc cgcggactcg gtgacatcac
     1981 cgcccagctc gttgatctcc ttggtgagcg cggcgaggcg gtcggtctcg tgcagccgca
     2041 gatgcgcgac gccccgcagg accgactccg agtcggcgag cgcggcgacg gccgcgatcc
     2101 ccggtgtcag ctcgccgacc tcgctcagat ccacgtcgat gccgtgcacg gcgccggaac
     2161 cggtgaagac gagcccctcg tcggtcagct cgcaggaacc gcccatctcg gtgaagatct
     2221 cccgcagccg gtcgccgggc tgcgtggtgc gcgcgggcca gtcgggaatg gtgacgcgac
     2281 ccccagtgat gagggcggcg gcgaggaagg gctgggcgtt ggacaggtcg ggttcgaccg
     2341 tcaggtcacg gccgagcatc gcactggggg agacccgcca cacattcggc tcgcccccgg
     2401 tctccggctc gtcgacctgc gcgccgaccc ggcgcagcat gtccaccgtc atccggatgt
     2461 ggggcatcga aggcagcgcg gagcccacgt gcctgacctc gacgccctgg ttgaatcgcg
     2521 gccccgacag cagcagcgcg ctcacgaact gggaggagga agaggcgtcg atctcgacgg
     2581 agccgccgtc cagcgccccg caaccgtgca ccgtcagcgg cagcgagcca cggcctccgt
     2641 cgtcgatccg cgcgcccagc gcggtcagcc cgtcgatcac cccgtgcagc gggcgctcgt
     2701 acgacctggg gtcgccgtcg aaacggatcg ggccgtcggc gagggtagcg accggcggaa
     2761 ggaagcgcat gaccgtgccc gcgttgccca cgtcgacggt ggcggggccg tgcagacccg
     2821 cggggatcac ccgccacgcc tcaccggcgg agcccgcacc cgacgcggtc ggggagctgg
     2881 agggcacggt ctcctcgata ccgaccccca tcgcccgcag cgcgccggcc atcagcaggg
     2941 tgtcccgcga gcgcagcggt cgacgcagcc agcccggctc ggcggcgagc gcggcgagga
     3001 caagaccacg gttggtgacc gatttggaac cgggcacctg gaccgtcgct gtgacgggtc
     3061 cactcgcgtg cggggcgggc cagagggcgg tgagggctgg gttttcggtc atgcccttac
     3121 tttagtggct ctcggtgacc acatatcttg atcaaataag ctgaaaccag gccgaaacag
     3181 ggtcctggta aagagcccga cgggtgcggc ggccgacctc tggggagggc gatccccgtg
     3241 ggcccccagt tgtttccggc cggccctccg gggtccgcgc ggcctcagag gccgagcagc
     3301 cagcgcccgc cgacggccag gcagccgagc gagacgacgt ggaagaagag gaaccacggg
     3361 ccggtcggca ccccggtcag ccgcgcgagc tggtcggcgt cggagtcgcc cgccccgccc
     3421 ctgcgccgct tggtctggag ctcgaaggcc gggcgtaccc cgccgagcag caggaaccag
     3481 accacgacgt acgcgaaggc cgcctgcacc tgagggcctg tgagccatga caccaggacg
     3541 aaggcgccgc cggtcacgat catggtgagc gctccgtagg cgttcctgat catcagcagc
     3601 atgagcagca gcaggaccgt ggcggcccag agcagcaggg tgatgtggtt cgccgcgagc
     3661 agccaggcgc cgccgaggcc gatcagcggg ggcgccgtat aaccggccgc ggccgtcagg
     3721 accatcccag ggccggtggg tctgccgcgg gagaccgtga ggcccgaggt gtcggagtgc
     3781 agcctgatgc cgtcgagacg tcggccgctg agcagggcga cgaggccgtg gccgccctcg
     3841 tgggcgatgg tgatcgcgtt gcgcgacagg cgccatatgc cgtgcggcac gatcgcggcc
     3901 agggccacga gaccggtgcc gaacaccagc cattgatcgg gatcgggctg actgccgaac
     3961 acgcggtccc acaggtcggc cagattggtg ctgtccattt ttcgggcggc tcctcggagg
     4021 cttcggggtc gtggcagtct ggcacttatg tgcggacggt ttgcagcgag tcgtggagcc
     4081 gaggatctgg cggggatctt cgggatagag aaatgggagc cggcggagac cctggcgccc
     4141 gactggaacg tcgccccgac caagcaggtc caggtcgtcc tcgaacgtcc gctcaagcac
     4201 gccgcggccg accccgacac cgacaaggac gctggtggcg gccgtccggt tcgccagctc
     4261 cgcaccctga agtgggggct ggtcccttcc tggtcgaaga cgcccgaggg cggcgcccgg
     4321 atgatcaacg cccgcgccga gaccgtccac gagaagccgt ccttccgcag ggccttcgcc
     4381 acccgccgct gcctcctccc cgccgacggc tattacgagt gggtgaccgg caccgaggaa
     4441 cgcgagctgg aggagaccgg ccgcaagaag cgcccccgca agcagcccta cttcgtgact
     4501 ccggccgacg gctcggtctt cgcgatggcg gggctctatg agttctggcg ggaccgcacg
     4561 ctgccggacg accaccccgg cgcctggtgg gtgacgtgct cggtgatcac cacggaggcc
     4621 gagaaggagc cgctggccgt cgctcctgag gagggcccgc gcgcgctggc cgacatccac
     4681 ccccggatgc ccctgatgct cacccccgac cgctgggacg cctggctcga cccgtcgtgg
     4741 accgagcccg acgacctgct cccgctgctc gccccgccgc ccggcgggct gctgcgcgcc
     4801 ttccccgtcg cgaccgccgt cagcaacgta cgcaacaacg gtcccgagct gctgaaggag
     4861 ctggaggggc ccgaggaggc cacgctgttc tgaccgcgcc gtccgcgcgg gccgtgctcg
     4921 ggcggcgcca cccgtacggg acgtgctcgg tcggtgccgt cggtacggga cgtgctcggt
     4981 cggtgccgtc ggtacgggga cgtgcccccc cggcgtcgtc ccggcggggc gtgatccggt
     5041 gccaccgcgt tcacgcgggg caggatgggc cccgtgacga gtgcgaagag cagtgagacg
     5101 gtcgacaccc cggccggaga ggcccgcatc acctggcacc ccgcgaaggc ggcccggctg
     5161 gtgctcgccg tgagccatgg agcgggcggc ggtatcgagg cgcgcgacct ccgggccctc
     5221 gccgccgtcc tgccggagca cgcggtcagc gtcgccctgg tggaacagcc gtggcgggtc
     5281 gcgggcaaga aactggcacc cgcccccaag accctggacg tcggctggcg cggagtgtgg
     5341 cccgcgcttc aggggccggg actgcccgtg atcgccggtg ggcgcagtgc cggtgccagg
     5401 gtcgcctgtc gtacggcgaa ggagctcggc gcccacgccg tcctggcgct cagcttcccg
     5461 ctgcacccac cgggcaggcc cgagaagtcc cgcgcggacg agctgctggg tgcgggggtg
     5521 cccgtactcg tcgtccaggg cgggaacgac cccttcggca agcccgccga attcccggtc
     5581 gaggtggtcg gtgcgggtgg tggtgcccat gagctggtcg aggtggcggg cggcgaccat
     5641 gggttcgccg tgcccaaacg gggtgctctc ggacaggacg acgctgtgag gatcatcacc
     5701 gacgccgtcc gggactggac cgcgcggctc tgagtcgatc gggccccgct cggtccggcg
     5761 cgtcactccc accaagggct tcttttccgg tctgtgcggg ggccgcggcc ccacggtgac
     5821 cgggcgcggg gtccctcggt cggccgaagc gcgaacatcg tgaacgaccg gcgccgaggc
     5881 gcgccgtcgc ggggctccgc cgtcccctcc cgccaccctc gtggggtggt tttctccgtc
     5941 ctcgcgctgc cccgaccggc cggaacgagc ctctcgggcg tgcggcccca cggcgggaat
     6001 gcggcgccaa gtgccgctgt tatgacgcat acagccacag ccgacgtgcg agagggagtc
     6061 cgccgcatgg gttcgaccat ctgcccgagc cgcagcagtt ccagtgacct ggactggtca
     6121 ctgctgcacg cggcgaagac cactcccgtc cgtgggacgg gcgggcggga tctccagccc
     6181 ctcgacccgg aaggtcgact attctccgat tcgagcggtc ggccggtctt cggtcgagcc
     6241 acggtgtcgg aggaggtggg tcgggtcact gggaccgacg caggaacgga tcacagccag
     6301 gcggagcagc cggaggagac gaccgcggag cgtaacgcgc gcttcgaacg ggacgcgctc
     6361 tccttcctcg accagatgta ttcggccgcg ttgcgcatga cgcgcaatcc ggctgacgcc
     6421 gaggacctgg ttcaggagac gtacgcgaag gcgtacggat cgttccacca gttccgtgag
     6481 ggcaccaacc tcaaggcgtg gctgtaccgg attctgacca acacgttcat caactcgtac
     6541 cgcaagaagc agcgcgagcc acagcgcagt gccgccgagg agatcgagga ctggcagctc
     6601 gcccgcgcgg agtcgcacat gtccacgggg ctgcgctccg ccgagtcaca ggcgctcgac
     6661 cacctgcccg actcggatgt gaagtccgcg ctccaggcga tccccgagga gttccgcatc
     6721 gcggtctatc tcgccgatgt ggaggggttt gcctacaagg agatcgcgga catcatgggg
     6781 acacccatcg gtacggtgat gtcccgtctg cacaggggcc gtcgccagtt gcgcgggatg
     6841 cttgaggact acgcccgtga ccgcgggctc gtcccggccg gcgccgtaca gtcggacgat
     6901 ctgaaaggat cgggctcatg agctgcggag agccgcacga gacggattgc agtgaagtcc
     6961 tcgatcatct ctacgagttg ctcgatcacg agatcccgga ctccgactgc accaagtacg
     7021 aggaccactt tcaggagtgc tcgccctgct tggagaagta cggcctcgaa caggctgtga
     7081 agaagctggt caagcggtgc tgcggacagg acgacgtgcc ggccgacctg cgggccaagg
     7141 tgcttggcag gatcgatctg atccgctcgg gccaagcggt gcccgagcag gacatcacgg
     7201 tcgcccgtcc ggagaccgcg gacaccgcgg gccgggttcc cgggcacctc acggagtcct
     7261 gaagccgagc ggcgggtccg cgcgtgggac gcgacgcgga cgacggtgcc atagcaggcc
     7321 catacagcgg gccgcgacaa cagtcgcggc ccgctgagac ttttctcccc gcccgcgcgg
     7381 ccgcccctgg caccgtacga ggcgtacggc cccggccctc gtcgccgccc ccgccgtgtc
     7441 cgccgaacgg gtgacgggag ggcgtcggcc gtatcccacg cgcgaaggtc cgctcggcgg
     7501 ctggagcggc ccggtgtgcc gggccggatg tcggggaacc ctcggggcgg acggcgccgc
     7561 acagcggtct tacggtggcg ccgacggggt aacccatggg taatgagcgg ccgtccgacc
     7621 gtccgtggtt ggatgccaag agggcgcgta cgaccgcgtg ggtcgtcccg acgcgggcac
     7681 tggagcagcc gggggcggac ggaaccggaa gggccagggg cgtggcgggg acagcggccc
     7741 gaatcatcgg caggcgggaa tgcaggcggg aatcgtgagg atcttcggca agggacgaca
     7801 ccggccctcc gcctcatggc ggcaggccac cgatcgcgcg ttcacgctga tcggcgacgg
     7861 tcggtacgag gacgccgggg ccctgctcac gcgcgccgcc gacctggagc cctggctctc
     7921 cgagtcctgg ttcaacctgg cgctgctgca caagttccgg cacgactggg agcaggccag
     7981 ggccgcgggg ctgcgggccg tcgcgctcct ggacaggggc gccggagccc ccgactggtg
     8041 gaacgtcggt atcgcggcca ccgcgttgca ggactgggcg ctcgccaggc gtgcctggca
     8101 ggcctacggg ctgcgggtac cgggcagcgc cgtcgacacg gacgagccca gcggaatgga
     8161 gctgggcagc gcggctctgc ggctctcccc cgagggcgag gccgaggtgg tgtggggccg
     8221 caggctcgat cccgcgcgcg tggaagtgct ctccgtgccg ctgccgtcct cggggcggcg
     8281 ctggggcgag gtcgtcctcc acgacggggt gccgaacggt gagcgcacca ccgccgacgg
     8341 ccagggctac ccggtcttcg acgagataga actgtgggcg ccctctcccg tgccgacctg
     8401 ggtggtgctg ctggaggcgg cgggcgagga cgacagggac gcgctggtgg agctggccgc
     8461 ggaagcgggc ttcgcggcgg aggactggtc gtcgtcggtg cggctgctgt gccggatgtg
     8521 ctcggagagc cggatgccga gcgacgaggg cgacggcgag caccttgacc cccacgacca
     8581 cagtgagccc ggccacccgg ggccgctcgg ccaccgcagt ccgggggagc tgtgggtgcc
     8641 cgagcgcgag tgcggcatcg cggccccgtc ctcgctggta cgcgggctgc tggacggctg
     8701 ggtcgcggac agccccgact cgcgtgactg gcgggacctg gaagaggtct gctagacccg
     8761 gccggatggt gaagaggtcc gtggggcccc tgatccgatg gcgctcgacc ccgagcagtc
     8821 cctgcgggct ccgtgcggac ggcccgcgcc cccccgcgcc ccccgcgctc gtcacatccg
     8881 aaagacacgt cccagccgcg gcccgtaggc tgtgcgggca cacgtggcgg gccgaaggac
     8941 gatccggccc aggtttcagg aaggcgtacc ggcggacatg gcgcagcagg acactgagca
     9001 cgagcaggcg caggacgagg gcgtgctgcc cgtcgacgac gagggcttcg tcatcgacac
     9061 cgaggacgcc ggggagcgcg aagaggcccg ctgtgcccgg ggcacggccc ggccgatcac
     9121 ggtcgtcggc aaccccgtgc tgcacaagga gtgcagggac gtcaccgtct tcgacgagga
     9181 gctcgaccgg ctcatcgacg acatgttcgc aagccagcgc gccgccgagg gcgtcggcct
     9241 cgcggccaac cagatcggtg tcgatctgaa ggtcttcgtc tacgactgcg gggacgacga
     9301 aggggtgcgt cacgtcggcg ccgtctgcaa cccggtcctg cgggagctgc ccgccgacca
     9361 gcgcaggctc gacgactcga acgagggctg cctctcggtg cccaccgcct acgcggagac
     9421 cccgcgcacc gactacgccg aggtgacggg gcaggacgcc aggggcaacc ccgtgcggat
     9481 ccgcggcaac ggctacttcg cacgctgcct ccagcacgag acggaccacc tctacggcta
     9541 cctgtacatc gaccgtctct cgaagcgtga ccgcaaggac gcgctgaggc agatggcgga
     9601 gggcaccgcg cgttacgcga ccgtgcccaa cgcctgaccc ggcgcagcgg acgtccggcg
     9661 gttctgccgg tccgcacgcg cccgcccgga ccatcctccg ggccgccagg tcctccctca
     9721 ggggccttcg atttgtccgc gcccggccgg ggttcatcct ccggccgggc gttctggcat
     9781 atgcgcccgc actccggcat aggccgtatg ggcttgcggg gtgatccaaa tccggtcacg
     9841 aatagggatg ttctcggctc ttggcaatag tgctggccca aatctattcc cttttcggtc
     9901 agttgtaggg ctgaatggaa agcgcgcgga ttcacagcgg cgcgcgccca gcacggcgga
     9961 agggggcgtg agccgacagg ccgtcgaaag gggttcgctc gtgcctgctt atccacacag
    10021 cacttcgtcg tcgacgtcgt cggtgccgtc gacactcgca ctgccggtgg tcgaggcaga
    10081 ctttcctcgc aggctccacg agttttggcc aaagcttcag gagaagtcca aggcgtggct
    10141 gctcgaaaag cggctcatgg agccggacct ggccgagctc cacgccgacg gcctgcggta
    10201 caccgatctg gtcgccggct actacctggg ggcccccgac accatcctgg cgtccatcgc
    10261 cgatctcagc gtctggttct tcgtctggga cgaccggcac gaccgcgaca ccgtgcacgg
    10321 caggggacgg tcatggttcg cgttgaccgc tgacctccgg acggcacttg tggctccgag
    10381 gtctcatctg caccacgagg aaccgctggt ggcggccttc gccgactgcg tgcagcggct
    10441 cacgcagccg ctggggcgag gctggcgcga ccgtttcgtg gcccacttcg ccgacgtgat
    10501 cgactcgtac gacgaagagt tcaggaacag ggccgtcggg gaggttccca ccgtggacac
    10561 ctacgtgaag ctgcgccgga ggaccttcgg tcacgaagtc tggctcgacc tgctcgaatt
    10621 ggcggccgtc cgtgaactcc ccgaacatat cagggagaat gaggcctacc ggcgtgcagg
    10681 gatggccacg caggatttct ccgcctggta caacgacctg tgctcgctgc ccaaggaact
    10741 cgcgggcgac gaggtgcaca atctcgggat cagcctcatt cagcatcagg ggctttcgct
    10801 cgaagaagcg gtatcggagg tgcgtcgcag ggtcagcgga tgcgtcactg aattcctgtt
    10861 catcgagaag gatgtggtag cgctcgcaga cgccgcagcg gcggagggaa cttttgcggg
    10921 agtggaattg cgctccgccg ttctggcatg cctcgacaac atgcgcaatt ggttctcctc
    10981 cgtttactgg ttccaccacg agtcgggccg ctatcgggtg gagagctggt ccgaccgctc
    11041 ccatccgccg tatgtcagtg accatctgcc aggaggcggt caggagcccg ccgctcctcc
    11101 cgcggggccc cgcgggcaac ggtggcggcg gcgccgggca tcggcggaga acaagaagac
    11161 gggtgacgca tgagtacgcg agcgacggca agcgccgcag gccgtgagag ggacgccccg
    11221 ccgctcgtca gcggcgcgct gccgctggtg ggccacgggc tgagcctggt ccgcggcccc
    11281 ctggcgttcc tggagaccct gcgcgaccac ggcgagctgg tcaggatcaa gctgggcccg
    11341 cgtacggcct acgcggtgtg cgcgcccgaa ctggtcggca ccctcttgaa gagcccggac
    11401 tacgccgtcg gcggccccct ctgggagacc ctggaagtcc tcctcggcaa gggggtcgcc
    11461 acgagcaacg gcgccgtgca ccggcgtcag cgccgtgcca tccagccggc cttcaggacc
    11521 gagcggatcc cggagtacgc ggtggtgatg cgggaggagg cgtgccgcac ggcggaccgc
    11581 tggcaggagg gccgtacggt cgacgtcggg gcggagatgt tccgcaccgg ggtgcgtatc
    11641 gtctcgcgct cgctgctgga gggcgactcg atcggcgaga aggccgaccg gatcagtgag
    11701 tccctgcaca ccgtcttcag cggcctctat cagcggatga tcctttcctt cgggccgctg
    11761 caccggttgc ccacccccgc caaccggcgg ttcgcgcgtg ccctcgccga tctccactcc
    11821 gtcatcacgg agatcatcag ggaacgccga gaatcggcca tcgagtcgga cgacttgttg
    11881 gccgtattgc tggcgacgaa ggacggagac ggaaagcccc tgagcgagca ggaggtgcac
    11941 gacaatgtcg tctcgcttgt cgtcgcggct gccgagaatg tcgcggccac gctagcctgg
    12001 acgtttgagc tgctcacaga acaccctggc cacgaaagca ggctgttcca agaagtggaa
    12061 tcggttgcgc cgggtcgccc tgtggatttc gatgacctcc agaacctgcc ctacacgcgc
    12121 aatctgatta tggaagccat gcgcatacgc ccggccgcgt ggatattcac gcggagagca
    12181 gtggccgata ccgagttggg cgggtatcgg ataccggccg gttcggatat cgtatacagc
    12241 gcctatgcca tgcagcgcga cccgcgttcc ttcgaacagc ctcatgagtt cgacccggac
    12301 cggtggcttc cggaacgggc cgcctccgta ccgccgttcg cgatgatgcc gttcggcgtc
    12361 ggcaaccgta agtgcccggg ggaccactac agcctggccc aggtcgcgct ggtcctcgcc
    12421 aacatcgtgc gcggctggca cctgtcgacc gtccccgaga ccgacggcaa cccgcgcatc
    12481 gggatcacgc tccagccgaa gcggctgctg ctcaggccgg agcggcgctg aaccgcaggc
    12541 ccgtgccctc cgcggcagcg gacggcacgg gcctgcggta cgggtcggcg gcagggggga
    12601 gggcagcccc ctgccggggc cagggagact cctagaactc gtcgtcgaac gagaccgaac
    12661 cctcgaccgc cacctggtaa gccgaggggc ggcgctcgaa gaagttggtc agttcctgca
    12721 cgccctggag ttccatgaac gagaacgggt tgctcgaacc gtagagcggc gcgaaaccca
    12781 gacgctgaag gcgctggtcg gccacgcact ccaggtactc acgcatcgag tcggtgttca
    12841 taccgggcag accctcaccg cagaggtcct gggcgaactg cagctcggag gcgacggcct
    12901 ccttcagcat gtcggtgacc tgctgctcca gcgcgtcgtc gaagaggtcg ggctcctcct
    12961 tgcggaccgt gtcgaccacg tcgaaggcga agctcatgtg catcgtctcg tcacggaaga
    13021 cccagttggt cccggtcgcc aggccgtgca gcagtccccg cgagcggaac cagtagacgt
    13081 acgcgaaggc tccgtagaag aacagcccct cgatgcaggc ggcgaagcag atcaggttga
    13141 gcaggaacag ccgccggtcc gccttcgact ccagccggtc caactggtcc accgagtcca
    13201 tccagcggaa gcagaactcc gccttctccc tgatggaggg gatgttctcc accgcggcga
    13261 acgcggcggc gcggtcgtcc gggtcgggca ggtaggtgtc gagcagcgtc agatagaact
    13321 ggacgtgcac ggcctcctcg aagagctgcc tgctcaggta gagccgggcc tccggagagt
    13381 tgatgtgctt gtacagcgtc agcaccaggt tgttggagac gatcgagtca cccgtcgcga
    13441 agaacgcgac caggcggccg atcatgtgct gttcctcggg gctcagcttg gcgaggtcgg
    13501 tcacgtcgga gtggagatcg acctcctcca cggtccaggt gttcttgatc gcgtcccggt
    13561 agcgctcgta gaagtcgggg tagcgcatgg ggcgcagggt cagctcgaaa cccgggtcga
    13621 gcaggttctt ctccgcggcg gccttcgggt cggcggagtg cgccgtggtg gtgttctcgg
    13681 cggtggtcat tactggcagg cctcgcagga ctcggggttt tccagggagc aggcgatggc
    13741 gtccgcgtcg ggagccggct gctgggtggg aacggtggcg ggggaggggg cggtggcggc
    13801 ctcggcggac ccggccgcgc gggcgatccg ggtcgcggga cgcgagcgca ggtagtacgt
    13861 cgtcttgagc ccctgctgcc aggcataggc gtacatcgag ctgagcttgc cgatggtcgg
    13921 cgtctccatg aacaggttca gggactggct ctggtcgagg aaggccgtac gccgggccgc
    13981 catgtcgatg agaccgcgct gcgggatctc ccaggcagtg cggtagaggt cgcgtacctc
    14041 ctgggggatc cagtggaacc ccgccaccga gccgctggac tcgcgcagcg cctcacgggt
    14101 acgtgcgtcc cagacgccga gccgcttcaa ctcccgtacg agataggtgt tgacctgaag
    14161 gaactcgccg ctcagcgtct cgcgcttgaa caggttcgac acctgcggct ccacgcactc
    14221 gtagacgccc gcgatcgagg cgatggtggc ggtcggggcg atggcgagca gcagcgagtt
    14281 gcgcatgccc accgaagcga tcctggcccg cagcgcgctc caccgctccg gccaggtcag
    14341 ctccacgtcg tagtggtcgg ggtggagcac accgcgcgcg gtgcgggtct tctcccaggc
    14401 gggcagtgga ccgttcttct ccgcgaggtc ggcggaggcc tcgtaggcgg cgagcatgat
    14461 ccgctcggcg atccgggtgg agagcgcctt ggcctcggcc gagtcgaagg gcagacccag
    14521 cttgaagaag acgtcctgga ggcccatcac gccgaggccc acggggcgcc acttcgcgtt
    14581 ggagcggccc gcctgctccg tcgggtagaa gttgatgtcc acgacacggt cgaggaaggt
    14641 caccgcggtg tgcacggtct cgtccagccg cgcccagtcc atggtgtgac cgtccacgaa
    14701 cgcgccgaga ttgaccgagc cgaggttgca gacggccgtc tcaccgtcgt tggtcacctc
    14761 aaggatctcc gtgcagaggt tcgaggagtg cacggtgtgg ccgggctcgg ccgtctggtt
    14821 ggccgtgcgg ttggaggcgt ccttgaaggt catccagccg ttgccggtct gggccagggc
    14881 gcgcatcatc ctgccgtaca gctcacgggc ggggatggtc cgcttggcga gccccgccgc
    14941 ctccgcggcg cggtaggagg cgtcgaactc gtcgccccac aggtccacca ggtcgggcac
    15001 gtcggagggg gagaagagcg accactcctg gtcggccgcg accctgcgca tgaactcgtc
    15061 ggggatccag tgcgccaggt tcaggttgtg cgtgcgcctg gcgtcctcgc ccgtgttgtc
    15121 gcgcagttcg aggaactcct cgatgtcgga gtgccaggtc tccaggtaga cggcggcggc
    15181 gcccttgcgc ctgccgccct ggttcaccgc ggccaccgag gcgtcgagcg tcttcaggaa
    15241 gggcacgatg ccgttggagt ggccgttggt gccccggatc agcgagccgc gcgagcggat
    15301 gcgggagtac gagaggccga tgccgcccgc gtgcttggag agcctcgcca cctcgcggta
    15361 gcggtcgtag atcgagtcca gctcgtccag cggcgactcc agcaggtagc aggaggacat
    15421 ctgggggtgg cgcgtaccgg agttgaagag cgtgggggag gacggcaggt agtccagccg
    15481 gctcatcagc ccgtagagcg aggccacctc gtcgacggcg tcgacactct cgtccgccgc
    15541 cagacccgcg gcgacccgca gcatgaagtg ttgcggggtc tcgacgacgc cgcgggtgat
    15601 cgggtggcgc agcagataac ggctgtagag ggtgcgcagc ccgaagtacc cgaaacggtc
    15661 gtcagccccg gtgtcgatca gcgcgtcgag ccgggcggcg tggaggctca cgaacgccgc
    15721 cgtacggtcg gcgatcagcc cctcgcggtg acctgtggcc accgattccg agaaggagcg
    15781 cacgccctgc gcggccgctt cctcggcgat gctgatcgtc agcagcctgg ccgcgagccg
    15841 ggagtaggcg gggtcctcgg agatcagccc cgccgcggcc tccgtcgcca gccctcgcag
    15901 ctcggcctcg tccgaggcgg cccccctgcc gcgcagcgcg gcggcggcga cccggccggg
    15961 gtcggtgtcg gggagatcca ccgtcagctc ggtcagggtc cgcagcagcg cggttcccgg
    16021 aaggtccgat tccgtctgga aggctgatac aggatcggct ggcgcgatgg tcacgttcga
    16081 tctccctcgc tcggctctgg gtcggcggcg agacggggat gcgcgggcgt ccgtcacccg
    16141 ggcagggcgt ggcgccgcgt ccaccggccc attccgcgag gcccggacgt cgtgtgcacc
    16201 cgggccggtc ggaccgggtg cgccgtccgc aggtgctcgg actggtgggc gcgccaaata
    16261 cgcacttgta caccgttgcg ggacagttcc ggattcgcac cgaattcccc tgcgacgaca
    16321 gcgaggtcga gcatacatct ggtggccgcc ttgggaagca ccccccatat ctagtgtcga
    16381 ctcgcctacc gacagctcat gagggcacac cgaaggccga gatccgcgct ccggggtgag
    16441 tggcccaccg tacgcctgga ggggcgggcg ccggtacgcc ggaggacggg cgggcggcgc
    16501 gtccgggagg gcgggcaggc ggcgcgccgg agggcctggc gggcggtacg ccggaggggc
    16561 gggcggcagt gtgccgtccg cccctccggg cgtgctggag gtcggcctgt cggcggccgg
    16621 ccggggatcg gaccagccgt cagtgccccg cgggagtccc cgcggtcgcg ggcggcagct
    16681 ccgtctcgac gcccgggtcg cccacgtccg ccgtgtagtc ggagcgggcc gtctcgtcga
    16741 cgccctgggg ggccttcagg gccctcagga cgaccgtcag gacgagggtc accacgacgt
    16801 tcagcacgaa ggccgtcatc ccgatgtaac ccatttggcc gatgccgggg atgagcttgt
    16861 tggacccgcc gaaatggtcc tgggtcgggc tcgccacgcc gtacgcggcc caggtgccgt
    16921 agaccatgcc gaccgcccag cccgcgagca gcgcccaccg gtggagccag cgggtgaaga
    16981 gcccgccgac cagggagggc atcgtctgaa ggatccagat gccgccgagg agctggaagt
    17041 tgatcgcgac ggtcttgtcc atgccgagta cgaagatcag cgccccgacc ttcacgagca
    17101 gcgagaccag cttggagacc ttgtactcct gggcgggggt cgcgttcggc ttgatgaagt
    17161 ccttgtagat gttgcgagtg aaaagattgg ccgcggcgat cgacatgatg gcggccggta
    17221 ccagcgcgcc gatgccgatg gccgcgaagg ccaccccggt gaaccagtcg gggaacatgt
    17281 tctcgaagag ctgcgggatg gcgagctggc cgttggagac cttgacgccc gcggcgatcg
    17341 ccatgaaccc gaggatgccg agcagcccga gcatcaggga gtagagcggc aggatcgtgg
    17401 tgttgcggcg gatcacgttg cgactgcgac tggagagggt cgccgtgatc gagtgcggat
    17461 acatgaacag cgcgagcgcc gagccgaccg ccagggtcgc gtacgcccag gtcgcctcgg
    17521 aaccgggggc gagcgcgccg acaggtttgt cggtggccgg gttgatcgtc tcgaacttct
    17581 tgctcgcggc ggcgaagatg tcgtcgaagc caccgagttt gatcgggatg tagatgatcg
    17641 cgaccaggat gaccaggtag atcaggccgt ccttcacgaa cgcgatcagc gcgggcgcgc
    17701 gcagccccga cgagtaggtg tacgcggcga gcaccgcgaa ggcgatcagc agtggcaggt
    17761 ccttgatgaa ccagttggtg ttctcaccgc cgccgatgcc catcacgtcg agcaccgcct
    17821 ggatgccgac gagctggagc gcgatgtacg gcatcgtggc gaggatgccg gtgaccgcca
    17881 cggccagcga aagccccttg gagccgaacc gcccgcgtac gaagtctgag gtggtgacgt
    17941 atccgtgctt gtgcgacacc gaccagagcc gcggcaggaa ggtgaagatc agcgggtaga
    18001 ccaggatcgt gtaggggacc gcgaagaacc cggaggcccc cgccgcgtag atcgccgcgg
    18061 gaacggccac gaaggtgtac gccgtgtaga ggtcgccgcc cagcaggaac caggtcaccc
    18121 aggtaccgaa cgaccttccg cccaggcccc attcgtcgag ggtggcctcg ttgtcggccc
    18181 tgcgccatcg ggcggccatg aagcccatga cggtgacggc cacgaagaag aagatgaaga
    18241 cggcgagtgc gacgccgttc acgccgtcgt tcactggtgt gctccctcac gcgcggctcc
    18301 gcgcgtccgc tggtcacgct gccagagctt gtaggcggtc atcgtcagcg cgctggagat
    18361 gaagacccac agcatctggt accagtagaa gaacgggatg ccgatgaagg cgggatccac
    18421 cttggcgtag gaactcaccc agagcatcgc cacgaatggt gcgaccagac acaggccgat
    18481 caccacgcgc acgggggtga cgacgggccg ttgcggcccg ctccctcccc ctgttccgct
    18541 tgctggttct tcttctcgcg ccatggggcg gctcccgttt ccctcgttga tcgttggcac
    18601 aacgccggag aaatctaagg gacacacagg cgtagtggaa gccctgtacc gcatagcgga
    18661 cgtaaaggcg acgtaaggga gttgagaggg gtcagcgggt ggtcgggcgg gggcccggcg
    18721 ggcggccggg agggtggccg gacgcgaggt cgggcaggcg gccggcgggc gccccggtgg
    18781 atggccgggc aggcgttcgg tcgggcgtgc ggccagacgt gcggccaggc gttcggtcgg
    18841 gccttcggtc gggtggcccg acgggcgggc cgacgggcgg gccgacgggt ggtcaggacc
    18901 gtgggatccg gaccacccgg ggctcagtcg accggccgct tgaggcgggc gaggaacttg
    18961 tagcggtcac cgcggtagac cgatctgacc cactcgaccg gctcgccccg cccgtcgacc
    19021 gagtggcgcg agagcatcaa catcggcagc cccacatcgg tgccgagcag ccccgcctcg
    19081 cgtggggtgg ccagcgaggt ctcgatggtc tcctcggcct ccgcgagccg cacgtcgtac
    19141 acctccgcga gggcggtgta gagcgagctg tacttcacca gggagcggcg cagcgcgggg
    19201 aaacgcttgg ccgagaggtg cgtggtctcg atggccatcg gctccccgct ggcgagccgc
    19261 agacgctcga tacgcagcac ccggccgccc gtcgtgatgt cgagcaggcc ggccagcgtg
    19321 tcgtcggccg tgacatagcc gatgtccaga agctgggacg tgggttccag tccctgggcg
    19381 cgcatgtcct ccgtgtacga ggtcagttgc agcgcctgga acaccttggg cttggcgacg
    19441 aacgtgccct tgccctggat gcgttccagc ctgccctcga ccaccagctc ctggagggcc
    19501 tggcggacgg tggtgcgcga ggtgtcgaac tccgacgcga gagtacgctc gggcggcacc
    19561 ggggtgccgg gtggcatcgt ctgcgtcatg tcgagcaagt gccgcttcaa gcggtagtac
    19621 ttgggcacgc gtgcggtgcg cgtggcgacg ccgggatccg cgacgggcga gacgcccacc
    19681 ccggtctcgc tactgccccc gtcggtggcc atggcctgcc tctccggctc ctgtgctgct
    19741 gccgtcaccg gctcctccgt ctgtcgcgga tcacatcgtg gcacgcccgg gggcacaagg
    19801 gtccttctcc ctcaggtgtc ggtcccataa cggaggcgac agcccttctt atacaccctt
    19861 gacaccccta aaggtctagg ccaagctccc cggtactggt ctacaccatt aaagaccagg
    19921 tccctatccc acgggcagta ccggtctatg tcctcggtat cggtgggggg ttgcaggcat
    19981 cctgaggagg gtggcgtgaa gcgcaagctc atcgcggcga tcggcgtcgc gggcatgttg
    20041 gtctcgatcg cggcatgcgg tggtgacagc ggcgacgaca acggaggcaa caaggcgggc
    20101 gccgacggct acaaggggca gacgctcacg ctctgggtca tggacggatc gtcacccgac
    20161 ggctggcaga aggatctcaa ggcggccttc gagaagaaga ccggcgccaa gctgaaggtc
    20221 gaaatccaga cctggaacgg cattcagcag aagctgacga cggccctctc ggaggagaac
    20281 cctcccgacg tcttcgagat cggcaacaca cagacctccg cctacgccaa gaccggtggc
    20341 ctcgcagaac tcggtgacct caagtcgtcc atcggcgccg actggtcaaa gagcatgaac
    20401 gagtccgccg tggtggacgg caagcagtac gcggccccgt ggtgggtgaa caaccgcgtc
    20461 gtcgtctaca acaagaagct gtggaaggaa gccgggctca aggagacacc gaagacccgc
    20521 gacgagttct acaaggacct caagcagatc ggctccaaga ccggcgcgga gccgatctac
    20581 ctgcccggcc agttctggta ccacttcgtc ggcctcggta tcgccgaggg cgccgagctg
    20641 gtcaagaagg agggcggcaa gtgggtctcc aacctggacg acccgaaggt cgccgccgcc
    20701 atggagacgt acaagaagtt ccagtcgctc tccaaggctc ccaaggacaa ggacgaggcc
    20761 accccgcagc aggccgaggt cttcgccaag ggcaagaccg gcgccttcat cggcatgggc
    20821 tgggaggccg cgaccgccgt caaggccaac ccgaagatcg agaaggacat cggctacttc
    20881 acgatccccg gtgccaccgc cgacaagccc gagggtgtct tcctcggcgg ctcgaacctc
    20941 gccgtctcgg ccggcagtga gaggcaggaa ctcgcgaagg agttcctgaa gatggcgctc
    21001 tccgacaagt tcgagggaca gctcgccaag gaaggcggcg tcatcccgaa caagcaggcg
    21061 ctggagtccg agctgaaggg caacgcctcc gccgaggccg ccgcccccgc cgcgggcgac
    21121 ggtggcacga cgccgctgat cccggagtgg gccgctgtgg agaacgcgcc caa
//
