LOCUS       NZ_CP045178            25131 bp    DNA     linear   CON 25-NOV-2024
DEFINITION  Streptomyces tsukubensis strain AT3 chromosome, complete genome.
ACCESSION   NZ_CP045178
VERSION     NZ_CP045178.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces tsukubensis
  ORGANISM  Streptomyces tsukubensis
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8615214)
  AUTHORS   Cao,G., Zhong,C., Fu,J., Zhang,P., Liu,M. and Zong,G.
  TITLE     Complete genome sequence of Streptomyces tsukubaensis AT3
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8615214)
  AUTHORS   Cao,G., Zhong,C., Fu,J., Zhang,P., Liu,M. and Zong,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-OCT-2019) Shandong Medicinal Biotechnology Center,
            Shandong First Medical University, 18877 Jinshi Road, Jinan 250062,
            China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 01-OCT-2019
            Assembly Method :: SOAPdenovo v. OCT-2019; SPAdes v. OCT-2019
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 997.0x
            Sequencing Technology             :: Illumina HiSeq; PacBio RSII
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_009296025.1-RS_2024_11_20
            Annotation Date                   :: 11/20/2024 08:40:01
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,005
            CDSs (total)                      :: 6,919
            Genes (coding)                    :: 6,691
            CDSs (with protein)               :: 6,691
            Genes (RNA)                       :: 86
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 65
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 228
            CDSs (without protein)            :: 228
            Pseudo Genes (ambiguous residues) :: 0 of 228
            Pseudo Genes (frameshifted)       :: 76 of 228
            Pseudo Genes (incomplete)         :: 184 of 228
            Pseudo Genes (internal stop)      :: 10 of 228
            Pseudo Genes (multiple problems)  :: 38 of 228
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 05:10:03
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4197021
            Orig. end                         :: 4222152
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP045178.1.
            Bacteria and source DNA available from Dr. Guangxiang Cao.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..25131
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="18"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..25131
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25131
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:15131](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..15131
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            10..330
                     /locus_tag="GBW32_RS17805"
                     /old_locus_tag="GBW32_17795"
     CDS             10..330
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007447303.1"
                     /locus_tag="GBW32_RS17805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_17795"
                     /product="DUF6238 family protein"
                     /protein_id="WP_227025185.1"
                     /transl_table=11
                     /translation="MTVTTANPTLPAAERAVRQDLDQLHAEALDLARRTKELAVVLDRG
                     DYSAAGGRVRTAVTHIWRAAEDLHSAFHTAPPRCAGPDASMSRLCGRRMRYLAARVARR
                     AE"
     gene            339..593
                     /locus_tag="GBW32_RS17810"
                     /old_locus_tag="GBW32_17800"
     CDS             339..593
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="GBW32_RS17810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GBW32_17800"
                     /product="hypothetical protein"
                     /protein_id="WP_143621482.1"
                     /transl_table=11
                     /translation="MPDGISLALYAVTAVLALALVTLWFLLNRGRRNAGFASKGQLNRQ
                     MSAKAVLKATEIRPSLTSDDSQPNRAAGVSFVKKRPTAR"
     gene            633..2081
                     /locus_tag="GBW32_RS17815"
                     /old_locus_tag="GBW32_17805"
     CDS             633..2081
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007447312.1"
                     /locus_tag="GBW32_RS17815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_17805"
                     /product="type IV secretory system conjugative DNA transfer
                     family protein"
                     /protein_id="WP_077972426.1"
                     /transl_table=11
                     /translation="MHHPLDPHDFGYSLGTSQRPKGVELWSRADKACRVIGPMGSGKTL
                     RFFAPLIRNWAGPVLATSTKPDLVELTLDARQREGRPVAVFDPQNIAPSLPKFRWTPIN
                     GAADTEVAMMRGKAFVAGSRTPNGAAQSSEGSAFYKGQASKILAAFFHAAALDGASLDW
                     VLRWARKLTDPAPLGILNAHPGAGPGWADMLRTATTGDSRTVGNTASTLDAALEPFMHQ
                     SVINALQGDGEDPTDFGAFLDSGGTLYLLGKDSEVNSVAPLTTAIAEDLLDFGEAHALA
                     SPAGRLDPALLAALDEAPNIAPIPSLRQRVADGRGRGITVVYGLQAWASARARFGEDTA
                     KELAAFTNNVIVLPGDKDPDFLKDMSDLCGQVERERKTKTTSGGDRGGHSTATHMALEP
                     VLRGDEIRRLAEGHALVLADNLPPIVTRLDGMWTWDSWAEIEGHVRDLRAANEAERTER
                     ATDKKKRAKAHAEAWAGREGAAAA"
     gene            2078..2581
                     /locus_tag="GBW32_RS17820"
                     /old_locus_tag="GBW32_17810"
     CDS             2078..2581
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007447313.1"
                     /locus_tag="GBW32_RS17820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_17810"
                     /product="hypothetical protein"
                     /protein_id="WP_077972425.1"
                     /transl_table=11
                     /translation="MTEILTHFEPFPEPPALILEYIAERSTEESVAADGPAPWDLGALS
                     AELIAPMPAWLDSVCRWLNRTYAWQPQDVIPPCWVKHEGLAYEIAALAFARGDAYAEAG
                     SSVIWHEQYDRFLTRMNKTLGKAGDECRVGRHDERPARFQLAAWPTAMGEETGSVGRVE
                     EMAG"
     gene            2578..3015
                     /locus_tag="GBW32_RS17825"
                     /old_locus_tag="GBW32_17815"
     CDS             2578..3015
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007447314.1"
                     /locus_tag="GBW32_RS17825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_17815"
                     /product="hypothetical protein"
                     /protein_id="WP_077972424.1"
                     /transl_table=11
                     /translation="MMADPNMVFSTDPRHGLVARSGWEQEEARTVLRDLGWEWAEELHA
                     LVPPDDVPEVDSGLQAVEELHLHGHRTGYAVGPYGTMRLTLDRAEQVFTKVAAQEPGEA
                     TAGVDAKDDQPARAEARRPRYGGVPASEGPGEPDGPESPAI"
     gene            complement(3093..3725)
                     /locus_tag="GBW32_RS17830"
                     /old_locus_tag="GBW32_17820"
     CDS             complement(3093..3725)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_process="GO:0008152 - metabolic process [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016571578.1"
                     /locus_tag="GBW32_RS17830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_17820"
                     /product="HAD-IA family hydrolase"
                     /protein_id="WP_032790300.1"
                     /sec_met_domain="HAD_2 (E-value: 1.2e-07, bitscore: 30.7,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPAPYRGLILDFGGVLTTRMRLNGQAFERTEGLTPGAYFAALNEH
                     PEGVAIYAALEVGEATQEDWNRVIGGILGIDSTDLMRRALANLHPEPQIVAAAKRARAA
                     GIKVAMLSNSFGIEPYNPYEDKGMWTDFFDAVILSELEGVRKPSPLIYQRALDALDLTG
                     PECVFVDDHAENLPPAETLGIRTVHHTTDPTGTAAILDSLLLDPAPA"
     gene            3900..5120
                     /locus_tag="GBW32_RS17835"
                     /old_locus_tag="GBW32_17825"
     CDS             3900..5120
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016571579.1"
                     /locus_tag="GBW32_RS17835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_17825"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_077972423.1"
                     /transl_table=11
                     /translation="MVYDGELFSIGQRIKWWRERRGLSQRMLGDLIGRSENWVYKIEND
                     RMPLDRLPILIALSKQLRCSLEDLTGGYVSGIVTAGTEHEHVPLIRQALSLPASLLPQR
                     IGSVTSDDFESSVTDAWKVYETQAEDRYRDVGERLPTLLRQGHAALRDASPEHEGTVLR
                     QLISLYSLHQIWLRRVGEPTLARIAADRSLSLADNAGDPALLAAAAWSLACVLTSAGDV
                     EDSYELARQTIAQCRPNDDSAPEHWSAYGALHLQGAVAAVRATKGPRAWDLYNGAKRAV
                     DRVGADLNHWHTCFGPTNFAMHEVHLKAEEGDTSEALRAADHVAVNEEVPLERRTRYLI
                     EVMNLNRIQRDDYATVHILGKLLKQSPEEIVFSPLVREAVADLLKREKPMWRDDLRAVA
                     KHIGLAA"
     misc_feature    5152..5161
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 15.26"
                     /tool="antismash"
     misc_feature    complement(5409..5428)
                     /note="TFBS match to DosR, Hypoxia stress response
                     regulator, confidence: weak, score: 23.27"
                     /tool="antismash"
     gene            5447..5638
                     /locus_tag="GBW32_RS17840"
                     /old_locus_tag="GBW32_17830"
     CDS             5447..5638
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="GBW32_RS17840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GBW32_17830"
                     /product="hypothetical protein"
                     /protein_id="WP_143621479.1"
                     /transl_table=11
                     /translation="MTARTPGDRARRRNLADASITPMPAFAGLLRRIPGQRHRTNPIAS
                     LEAPAPGHEGGSRIGTER"
     gene            5686..6102
                     /locus_tag="GBW32_RS17845"
                     /old_locus_tag="GBW32_17835"
     CDS             5686..6102
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024970.5"
                     /locus_tag="GBW32_RS17845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_17835"
                     /product="ATP-binding protein"
                     /protein_id="WP_227025528.1"
                     /transl_table=11
                     /translation="MKENFPITKRSPGELPPPVDESRVRAMRHVTRERLTSRGLTCVAD
                     DATLIVSELITNAILHSGGMQIQLTLDLRDGVLCIRVHDGVTGPRPTAQTPDDDDEHGR
                     GLVLVQEIARSRRGAWGVSDNGATTWCELSLVAC"
     gene            6096..6617
                     /locus_tag="GBW32_RS17850"
                     /old_locus_tag="GBW32_17840"
     CDS             6096..6617
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="GBW32_RS17850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GBW32_17840"
                     /product="hypothetical protein"
                     /protein_id="WP_077972421.1"
                     /transl_table=11
                     /translation="MLMTNTALRDWATSPETMPVRVKDPTVPTTPWTPPHDEEKARRYL
                     SAVREWASVDWNEVFDDLDTILHGEEEISHHAAGPSGGAPLPNYNDDARTQRFLMALKL
                     LVARALRDQADKKHPDIAGLIGQARTLRAEVVAGDAGQTIGLVRKLARLTLDLAELLEE
                     AGIVRGLVEC"
     misc_feature    6117..6119
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    6351..6353
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            6611..7072
                     /locus_tag="GBW32_RS17855"
                     /old_locus_tag="GBW32_17845"
     CDS             6611..7072
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007447319.1"
                     /locus_tag="GBW32_RS17855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_17845"
                     /product="DUF6302 family protein"
                     /protein_id="WP_077972419.1"
                     /transl_table=11
                     /translation="MLTTTKASTRSFVPSLCSAEEAYDFEHFRDRLARPEVLAHAVAVC
                     VFRAPLLAVPVGGPRRGGYMSFDLLPLAIGARGLLTNRPGFPNLRVRWSPYRDTCHTVE
                     WGDPAPEWWEDDAVFGRFYGYSEAAITTFVRQHPRPSPAVSVPCSPTAP"
     gene            7126..7335
                     /locus_tag="GBW32_RS17860"
                     /old_locus_tag="GBW32_17850"
     CDS             7126..7335
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014044720.1"
                     /locus_tag="GBW32_RS17860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_17850"
                     /product="DUF5999 family protein"
                     /protein_id="WP_077972417.1"
                     /transl_table=11
                     /translation="MCKHNPPCPTADASDREAARPAAAHPEQGWGLLCNGVLIFDDTGQ
                     LLPDGRIVKPHRSLLALQTMRRPG"
     gene            7332..8219
                     /locus_tag="GBW32_RS17865"
                     /old_locus_tag="GBW32_17855"
     CDS             7332..8219
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007447321.1"
                     /locus_tag="GBW32_RS17865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_17855"
                     /product="endonuclease/exonuclease/phosphatase"
                     /protein_id="WP_227025186.1"
                     /transl_table=11
                     /translation="MSVIDASRRPALQVPEAASARLRVGSYNVMDGGQDRWSGQLRLLA
                     SLDLDLLGIQEAKHWDRTDYARVHETAEALGMQPLFAPSRSHGCHLVLFYRWPRIQCRR
                     FRADISCGRFHHAASRAQFTVDGVDEPLWVLHTHLHPFSPAVRLTEAGWLTEYANPDRL
                     AVIIGDLNTGGLMDRDPDDWDQVPAHLHSRHRLVLPDGSYGGSDRRAMSALTKAGFVDP
                     PEQLGMEPPRTAGHWGRGSEPYDRRSDFVLLSRRLAPAVHDHRVVDTAETQRLGDHLPV
                     ITSVDLVRRKPRLL"
     gene            8399..9646
                     /gene="fxlM"
                     /locus_tag="GBW32_RS17870"
                     /old_locus_tag="GBW32_17860"
     CDS             8399..9646
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007447322.1"
                     /locus_tag="GBW32_RS17870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_17860"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_077972415.1"
                     /sec_met_domain="PCMT (E-value: 3.1e-41, bitscore: 140.1,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDNAPDLTTSTEQGAATEQQLRDTMVQKLIEAGAARSPRVVAAFR
                     TVPRHLATPEVEPAKTYEVETATITKTDEHGVDISSVSAPRIQAMQIEQAAIEPGMTVL
                     EIGSGGPNAAYLAEMAGENGRVVTVDIDADVTARAERFVAATGYRNISVVTGDAEHGVP
                     EHGPYDRIVVTVQAADIPSAWVDQLTNGGRLVVPLRMRSMTRTVAFVRDGDRLVSDGFE
                     QCGFVPMRGAGENRMRLAVLHDEEGAEVALRLDSGHAEPDTEALRAALRSPRSEAWSGV
                     TVGGEESKEHLDLWLTTALDNLPIMAAKVGARQRGIVAAASPIGLPALVDGGSFAYRTT
                     RPTDQEDRYELGAIGHGPDGRKVAERLVEEIQAWNDGHRSDRAHIEVYPAGTPDDRLPA
                     GRVIDRPHTRVIISWP"
     gene            9728..9916
                     /locus_tag="GBW32_RS17875"
                     /old_locus_tag="GBW32_17865"
     CDS             9728..9916
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR04363.1"
                     /locus_tag="GBW32_RS17875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_17865"
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_032790305.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 1.8e-13, bitscore:
                     48.9, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAPQITKSLPQTGTPFSAESGSDFDLNIETVSALPVVGALLNDTG
                     DGCTSTCQSACSNSTCG"
     CDS_motif       9728..9847
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MAPQITKSLPQTGTPFSAESGSDFDLNIETVSALPVVGAL"
                     /locus_tag="GBW32_RS17875_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9848..9916
                     /prepeptide="core"
                     /locus_tag="GBW32_RS17875_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="-5.80"
                     /molecular_weight="1981.1"
                     /monoisotopic_mass="1979.8"
                     /core_sequence="LNDTGDGCTSTCQSACSNSTCG"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MAPQITKSLPQTGTPFSAESGSDFDLNIETVSALPVVGAL"
                     /leader_location="[9727:9847](+)"
                     /alternative_weights="1999.1"
                     /alternative_weights="2017.1"
                     /alternative_weights="2035.1"
                     /alternative_weights="2053.1"
     gene            10001..13030
                     /locus_tag="GBW32_RS17880"
                     /old_locus_tag="GBW32_17870"
     CDS             10001..13030
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009319705.1"
                     /locus_tag="GBW32_RS17880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_17870"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_227025187.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 1.6e-174,
                     bitscore: 580.3, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 4.2e-15,
                     bitscore: 54.9, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.4e-27, bitscore:
                     95.7, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYRAVDASMIRTSVFPLVGLLPSCPAPVADGAADAENCRQWIKQV
                     WADDTVVSAVEIAAPVLAAAVRKVIDGKARRSRIRRTAHSVTRYLLRMQFRATPFGTFA
                     GPTSVRLGPRTSIRWGTQHTAFARADATWLHDFVTALEQDPEILRHLHIVADPTTTVRG
                     ATISVSCQPGADGPTETTLRRTKAAELVLSLAQAPTLVKDVVAKIKADYPDTAVTTIEG
                     MVRTLVAHRVLLTNLPAPMTRDDALGHLVDQLDRTSRAGAPDSAVRVRAEKLRHVHQLL
                     HQHDHAHPDEQCILRVQATTAMNQLTGVTEGSLAVHLRPDCNIVLPHQVAAEASRALDV
                     IGRITPYPNGTPAWRDYLTRFLERYSTGTVVPVRELTDPDTGLGFPVGYRSTVLPRPVL
                     ATTPRDEHLLALVQEAALTDRREIVLTEDDIEALSTGKPSQVPAHIEFTFTVLGQSKSA
                     LDEGRFTLSVVGLSLAAGITTGRFLPTLEPSDLDRVKAVHAALPTLTEGAVRGQVSGPP
                     LKVPINNVSRSPLVAPELLSIGEHNPDATLSLDDLGVVSDAVRFYLVSLSTGQVIEPTV
                     MNAVELSSSTHPLTRFVCELPRAHTAVLMPFFWGAASQLPFLPEVRVGRTVLSAALWRL
                     RHRDFGDGNDWNERLINWRCTYGLPRTVYLGASDQRLRLDLDEPVHQELLRAELKRHGK
                     AVLHEAPEESAFAWLDRAHEVAMTFASDQDRRPAPTIRSSTARNVGRMPGSSHWVYVKL
                     YGSTARVPEVLTGHLPRLLRHGWGTPPSTWFIRYADPEPHIRLRLRLPGPGAFGSAAQA
                     VAEWAAELRREGLLHRVQWDTDHSETGRYGTGRALEAAEDYFVADSAAAVAQLALVVPA
                     DLRPAITAASFVDITSGFLGSSKDAFTWLTQHLLRSDGGLVPRNIQALALRLSKPDARN
                     VLADFDGGDAVADAWEMRRHALDRYRQTLTGDAPDAVLPSLLHMHHNRAAGINPAAEAT
                     CRRIARAAAHSWTLIPEGEA"
     misc_feature    10021..10034
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 15.33"
                     /tool="antismash"
     aSDomain        10457..10717
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_GBW32_RS17880_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="1.70E-17"
                     /identifier="RREFam001.1"
                     /label="GBW32_RS17880"
                     /locus_tag="GBW32_RS17880"
                     /protein_end="239"
                     /protein_start="152"
                     /score="54.9"
                     /tool="antismash"
                     /translation="IVADPTTTVRGATISVSCQPGADGPTETTLRRTKAAELVLSLAQA
                     PTLVKDVVAKIKADYPDTAVTTIEGMVRTLVAHRVLLTNLPA"
     gene            13027..14169
                     /locus_tag="GBW32_RS17885"
                     /old_locus_tag="GBW32_17875"
     CDS             13027..14169
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007447324.1"
                     /locus_tag="GBW32_RS17885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_17875"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_077972413.1"
                     /sec_met_domain="LANC_like (E-value: 3.2e-38, bitscore:
                     130.1, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTAPPATDTATRQSLAHGPLGVAMLHIERARNGAGDWRDIHRIL
                     AGAGPLIDGGDANLFLGAPAMAFVLHLAADGTDRYAGALHTLDGVVASHTQQRLAAAHA
                     RIDAGRRATFAEYDLFRGLTGVGALLLRRQPHGAEMKGVLEYLVRLVNPVPDESGAALP
                     GWWVGHAPASDKTATPGGHANAGLAHGITGPLALLSLAMRAGITVDGHEAAIRRICRWL
                     DQIRQSDSRGLRWPRWVSHGGVSPALPATPGWCYGTPGLVRAQQLAAIVLEDADRKRMV
                     ERALTYCLGDSHQLDKIADRGLCHGFGGVLRTVQRVVEDADTPAEYGSRFSLLVQRFLT
                     ADVPEGGGFLVGKAGAALAFQDAEAGGSPQGQWDACLLLT"
     gene            14199..15131
                     /locus_tag="GBW32_RS17890"
                     /old_locus_tag="GBW32_17880"
     CDS             14199..15131
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009319709.1"
                     /locus_tag="GBW32_RS17890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_17880"
                     /product="thiopeptide-type bacteriocin biosynthesis
                     protein"
                     /protein_id="WP_227025188.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 4e-29, bitscore:
                     100.8, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEDAILAVLGGASVEETAHATDTGAAQLSEAIERYKDAGRAALDA
                     EPSGWHQMNIRFADYPSADRTFRAYLTPALRSYPVGTWWFVRKYPHWRLRFYPAPNASP
                     EDALRHVTEALDSSVSWSVTKEWTATPYEPEAIAFGGPVGMPLAQELFHADSVGVLGYL
                     GVAADGSARTLDAKATSLVAMTLLMRAAGLEFGEQGDVWGRVEERRPLAEDVSPEQVSS
                     MVEPMRRLLLSDARPLLNAGDLACVRPWIEGLEQGGEALADAAGSGNIGLGKRGILARH
                     VLFHWNRMGFTVRQQSIWSRAAREAVLGQ"
     misc_feature    complement(15493..15506)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 17.33"
                     /tool="antismash"
     gene            15537..15932
                     /locus_tag="GBW32_RS17895"
                     /old_locus_tag="GBW32_17885"
     CDS             15537..15932
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="GBW32_RS17895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GBW32_17885"
                     /product="hypothetical protein"
                     /protein_id="WP_077972411.1"
                     /transl_table=11
                     /translation="MTAQSAVFQCKLCPNNGTDRHFRGVGARMAAYRVCYSCDFWLMCL
                     GYAMLGDQDPDGRRALRIDGVHYLSWTEEQGFPPEIGYVGDEESRYVLLDDPAGTVHVT
                     RRLWLMGTIPDALRDRMPDNAIFAPPS"
     misc_feature    15570..15583
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.32"
                     /tool="antismash"
     gene            complement(15950..20395)
                     /gene="mobF"
                     /locus_tag="GBW32_RS17900"
                     /old_locus_tag="GBW32_17890"
     CDS             complement(15950..20395)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene="mobF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007447327.1"
                     /locus_tag="GBW32_RS17900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_17890"
                     /product="MobF family relaxase"
                     /protein_id="WP_227025189.1"
                     /transl_table=11
                     /translation="MGWVTMIGPSDEQVEYRLTGGHGCGRSVAVDAAPLIAAIEAKAEA
                     AGAPVASLLANREAKRAFFRARGLLRSKGAARFTGFDAVEVAAAAGLDARDLYGEQALP
                     PRAADGQVDYHLDASERPLVWIGGGLTEFDITPGSTLAPEQFPAARRLMLGEDPRAGQT
                     LVDPKLAIAPAAKLPAAPLARAIRRAAAERSVNPVSLLDSKRKQDAFRRMESQLKRFGE
                     SHRVPISTVLKLADAVGINAVDLYGEDTVEKAIAAEAGGHLDARALLRAVEARATETGQ
                     QPADLFDAVSMKRRYAQTEGEGARRLRDLPMDVREAVAMAKAAGLTPEDVWDAEEIKAA
                     LLEGRVQVGNRGADVTLDLSKSKSAFLAYAPEEIAAQVEGIYTAAGRESIGALERWTAY
                     AMRGRHGDGDEAETVKTSGFSGWMMVHRAARPVDGAPYGDPHFHLHFTLANMVKGTDGK
                     WSTMASGGRDLHRHTRATQSLMNARIRRELTNEFGISFRREERTGAWEIAAIPEATIRL
                     FSKRDSQVRDLLTKLGIDYDSATTRERTAASTASKAAKTGEAAGVGDDVLRAYWQAEGR
                     AAGDDPDAIAASAMEQDRADQNPTLGELCAQVFDPKNGLTSHSKEFTHAAAIAAVLDAL
                     PYGVGDAAEAEQLTNSVLRHAGYAVQLNPKGAQHFTHADRYTTADVVAAEALIVSEATN
                     RLSTQAAVVSSDTVDMTLSTVEAQHGGSFTFSDEQRAVLERLLTAGHGIDAVVGIAGSG
                     KTTIMDTARQAWEAHGLVIAGASTAAVAAANLKAEAGIESRTLASWLTGIRNGGSGLTG
                     VDVLVVDEAAMCDDRDIAELLTHAAETGTKVVGIGDPKQLHSPGIGGSFAAVHHLVGGL
                     TLSQNFRQKDMVERRALELWRDDNRVESLRTFAGTGRVHALADKDTALAAMLTVWADKR
                     AAHTDDHTAVQQLLMLAATNEIVEELNTGARALRKENGDLTGPEHAYALPGGGELTLSV
                     GDQVLLRVNDYRGKKSRGQNEDVLNGYRGIVRTVDEERRVLVEWREKTADGHRDVAEWV
                     DADYIAHGGLSLGYAITGHKSQGLTVQEALVYGPGAQANALYTMMSRDRAESHLFLPLS
                     VYETDGDRARHGDALTDQEQLDRAVAGLIREIENGTEERMILTELPKNAVPAHVRQAVA
                     DLPIPRAPGADEHHDADTPEEAPEHEDRPAAANTAPIPAPATPSEPAPTAARPYAHLGN
                     AALRDAVRKAAAAARATTAAADKAEAAADRAEREAAAGAGPRSLALQHRHQDVAEQAVA
                     IREVRSLDGTIAEHTTRLNSTEARIEGLDQQLAATGRFGRAALRGEERAAVESDREALL
                     RTREETVQELGQMDARLQDITRQAGPVNEYEAVLTEADMPQQEKATLLRRAKAKDDEAA
                     KQLRAEAIKARSTARGADHRVSGLQNETRLRAQHGRQHVDTDESEVPSSPKPESPYAKR
                     TEVDHMQPVPPDSTHDAPPV"
     gene            complement(20752..21153)
                     /locus_tag="GBW32_RS17905"
                     /old_locus_tag="GBW32_17895"
     CDS             complement(20752..21153)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="GBW32_RS17905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GBW32_17895"
                     /product="hypothetical protein"
                     /protein_id="WP_143621476.1"
                     /transl_table=11
                     /translation="MPNIETTPVIEFYGKKGEMDYKGEFTLTPGLHDFRNNSLPNDDTY
                     SFSVKNPQPGYTITIYNSATGSEDESWASYKLTDPFPMDPTRRINVDAGYQVPIGQEIV
                     PGVRANGHGAMAQLTGKVSSVRVAKDTTS"
     gene            complement(22178..22828)
                     /locus_tag="GBW32_RS17910"
                     /old_locus_tag="GBW32_17900"
     CDS             complement(22178..22828)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010644438.1"
                     /locus_tag="GBW32_RS17910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_17900"
                     /product="hypothetical protein"
                     /protein_id="WP_227025190.1"
                     /transl_table=11
                     /translation="MPRKTSRTLYSRADLRRVHGISEPTLQNLWSDRENNGHPPAKTVD
                     GVMHWDGDEWATWHHELQRQRAAANTSNPPKLDGDPEEMVGPAEAAKVCGFADSATISH
                     YVKNPPEGWPAPDDWDKLPTRDRPKWKRWRLWQYLADRKGRGHAGGRTAGRKGLAYPYQ
                     GDERLTLARQAIAANPGAKNAELIPQLQGQTEKTYSRPTWNLILKSAREHPEE"
     gene            complement(22872..23150)
                     /locus_tag="GBW32_RS17915"
                     /old_locus_tag="GBW32_17905"
     CDS             complement(22872..23150)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040353.4"
                     /locus_tag="GBW32_RS17915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_17905"
                     /product="DUF6211 family protein"
                     /protein_id="WP_077972407.1"
                     /transl_table=11
                     /translation="MLCDRHPDCPQPGDIAQLTRGNSIGADPGDNFVIVEDFPPTGRHL
                     VLNLPVDHPGRADWAAAVPLADIATLTRLEPAGSRTWTPAPEPDDIL"
     misc_feature    complement(23139..23149)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 17.67"
                     /tool="antismash"
     gene            complement(23348..23956)
                     /locus_tag="GBW32_RS17920"
                     /old_locus_tag="GBW32_17910"
     CDS             complement(23348..23956)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040384.4"
                     /locus_tag="GBW32_RS17920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_17910"
                     /product="DUF6349 family protein"
                     /protein_id="WP_077972405.1"
                     /transl_table=11
                     /translation="MTATVAEPSGARARQTYYWRVRNARTRHRPETAAQAWHIQPGHPG
                     GAYSDLGHELDPPAHHAPTLLSRSRPTGRRGEKQEFRAGCLACGWEGPVYSGGGFGDGD
                     NDAVEDAHDHAFPGWRTLPPINTVEDRWAVPRSRSRWAQFIARYPAGWVEQGAPVVAWR
                     RHHREAHRPPYAERPRYELHVPRPPRAQSRRPADQEALF"
     gene            complement(23953..24351)
                     /locus_tag="GBW32_RS17925"
                     /old_locus_tag="GBW32_17915"
     CDS             complement(23953..24351)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040345.4"
                     /locus_tag="GBW32_RS17925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_17915"
                     /product="DUF6181 family protein"
                     /protein_id="WP_077972403.1"
                     /transl_table=11
                     /translation="MDETTEDRSTTRTPSRRGAATPSRDGVHRLSVPLHPRLSATELIR
                     VLLAAPGEADLSTLDPVHVRSLIADVLTQHGYDVLDRSPYYPELDRHQDARRAVRRAYG
                     PRFLDAPDEQAVLADPLREVLAAGSRTP"
     gene            complement(24397..24824)
                     /locus_tag="GBW32_RS17930"
                     /old_locus_tag="GBW32_17920"
                     /pseudo=""
     CDS             complement(24397..24824)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040349.4"
                     /locus_tag="GBW32_RS17930"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_17920"
                     /product="DUF6197 family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MPTRHTPESIVIADTPAAILEWAARHIEHVGIHQGPRLFDGPGRT
                     ATLPCWPPAPSKSPPATGGEPPAGRTTGTASTAPATSRSPSSRKPSPVTPSTPRTRPPP
                     RPCTARPSTCGAPSPDVPLPTPPARSAPQPPAPNTPCS"
ORIGIN
        1 gccctcacca tgaccgtcac caccgccaac cccacacttc ccgccgccga gcgcgcggta
       61 cgacaggacc tcgaccagct gcacgccgaa gcactcgacc tcgcccggcg cacgaaggaa
      121 ctggccgtcg tactggaccg cggcgactac tccgccgccg gaggacgcgt gcgtacggcc
      181 gtcacccaca tctggcgagc cgccgaggac ctgcacagcg cgttccacac cgcgccccca
      241 cgctgcgccg gacccgacgc gtcgatgtcg cggctgtgcg gccggcgtat gcgctacctg
      301 gcggcccgcg tcgcccggag ggccgagtag tggacgtcat gcccgacgga atctcgctgg
      361 ccctgtacgc cgtgacggcc gtgctggcgc tggccctggt gacgctctgg ttcctgctga
      421 accgcggacg gcgcaacgcc ggattcgcga gcaagggaca gctcaaccgc cagatgtcgg
      481 ccaaagcagt cctgaaggcc accgagatca ggccctccct caccagcgac gacagccagc
      541 ccaaccgcgc agccggggtg agcttcgtga agaagcgccc caccgctcgc tgaccttctc
      601 acctcgttgc ccacctcgct ccggagtacg tcatgcacca ccccctcgat cctcacgatt
      661 tcggctactc gctgggtacc tcgcaacgcc cgaagggcgt cgagctgtgg tcccgcgccg
      721 acaaggcatg ccgggtcatc ggcccgatgg gcagcgggaa aactctgcgg ttcttcgccc
      781 cgctcatccg caactgggcc ggtccggtcc tggccacatc gaccaagccc gatctggtcg
      841 aactgaccct cgacgcgcgg cagcgggagg gccgccctgt tgcggtcttc gacccgcaga
      901 acatcgcgcc gagcctcccg aaattccggt ggacgccgat caacggcgca gccgacaccg
      961 aagtggcgat gatgaggggc aaggcgttcg tcgctggttc gcgcactccc aacggcgcag
     1021 cgcagtccag cgagggcagt gccttctaca aggggcaggc ttccaagatc ctcgctgcct
     1081 tcttccacgc cgccgccctt gacggcgcgt ccctcgactg ggtactgcgg tgggcccgca
     1141 agctgaccga cccggcaccc ctcggcatcc tcaacgcaca ccccggcgcc ggccccggct
     1201 gggcggacat gctccgcacc gccaccaccg gcgacagccg cacagtcggc aacaccgcat
     1261 cgaccctcga tgcggcgctg gagcccttca tgcaccagtc ggtgatcaac gccctccaag
     1321 gagatggaga ggaccccaca gacttcggcg cgttcctcga ctccgggggc accctctacc
     1381 ttctcggcaa ggacagcgag gtgaacagcg ttgcacccct gaccaccgcg atagcagaag
     1441 acctcttgga cttcggggaa gcgcacgccc ttgcctcccc ggccgggcgg ctcgaccccg
     1501 ctctcctcgc ggccctggac gaagcgccga acatcgcgcc catcccctcc ctccgccaac
     1561 gcgtcgccga cggccggggt cgcggcatca cggtcgtcta cggcctccag gcgtgggcgt
     1621 ccgcccgcgc ccgcttcggc gaggacaccg cgaaggaact ggcggccttc accaacaacg
     1681 tcatcgtcct gcccggagat aaggaccccg acttcctcaa ggacatgtcc gacctgtgcg
     1741 gtcaggtcga gcgagagcgc aagacgaaga ccacttccgg cggggaccgc ggcggccact
     1801 cgacggccac gcacatggcg ctcgaacccg tccttcgagg agacgagatc aggcgcctgg
     1861 ccgagggcca cgccctggtc ctcgcggaca acctgccgcc gatcgtcacc cggctcgacg
     1921 gcatgtggac ctgggactcc tgggccgaga tcgaggggca cgtgcgtgac cttcgggccg
     1981 ccaacgaagc cgagcggacc gagcgggcca ctgacaagaa gaagcgggcc aaggcccacg
     2041 cggaggcgtg ggccggccgt gaaggagcgg ctgccgcatg accgagatcc tgacccactt
     2101 cgagcccttc cccgagccgc ccgcgctgat cctggagtac atcgcggagc ggagcacgga
     2161 ggagtccgtt gccgccgacg gtcccgcccc gtgggacctc ggcgccctgt cagccgagtt
     2221 gatcgcgccg atgcccgcgt ggctcgattc tgtgtgccgc tggctgaacc ggacgtacgc
     2281 ctggcagcca caggacgtca tcccgccctg ctgggtgaag cacgagggac tggcgtacga
     2341 gatcgcggcc ctggccttcg cccggggaga cgcgtatgcg gaggcgggtt catccgtgat
     2401 ctggcacgag cagtacgacc ggttcctcac ccgcatgaac aagacgttgg gcaaggcggg
     2461 cgacgagtgc cgagtcggca ggcacgacga gcgtccggcg cgcttccagc tcgcggcctg
     2521 gcccaccgcc atgggcgagg agacgggatc tgtggggcga gtcgaggaga tggccggatg
     2581 atggcggacc cgaacatggt cttctcgacg gacccgcgtc acggactggt ggcgcgaagc
     2641 ggctgggagc aggaggaagc ccgaaccgtg ctccgtgatc tcggttggga gtgggcggag
     2701 gaactgcacg ccctcgtccc accggacgac gtgccggagg tcgactccgg ccttcaggcg
     2761 gtggaggaac ttcacctgca cgggcaccgg accgggtacg ccgtgggtcc ttacggcacg
     2821 atgcggttga ccctggatcg cgcggagcag gtgttcacga aggtcgccgc tcaggagcct
     2881 ggtgaggcca ccgccggagt ggacgcgaaa gatgatcagc ctgcaagagc ggaggccagg
     2941 cggcctaggt acgggggcgt acccgcttca gaaggtccgg gcgagcccga cgggccggag
     3001 tccccagcga tctagaacgc tctccagcaa gagcccatgg ctgtccttca gcgttcgagg
     3061 agccctagag gttcctcgaa cgctgctgtc gttcaggcgg gggcaggatc gaggagaagc
     3121 gagtcgagga tggcagccgt gccggtggga tcggtcgtgt ggtgcacggt gcggatgccc
     3181 agggtctcgg cgggcggcag gttctctgcg tggtcatcaa cgaagacgca ctcaggaccg
     3241 gtcaggtcca gggcgtcaag cgcgcgctga tagatgagcg gcgacggttt ccgtacgcct
     3301 tccagttccg acaagatgac ggcatcgaag aagtccgtcc acatgccctt gtcctcgtac
     3361 gggttgtagg gctcgatccc gaacgagttg ctgagcatgg ccaccttgat cccggccgcg
     3421 cgagcgcgct tcgcggcggc gacgatctga ggctccgggt gaaggttcgc cagagcgcgc
     3481 cgcatcaggt cggtggagtc gatgccgagg atgccgccga tgacacggtt ccagtcttcc
     3541 tgggtcgcct caccgacctc cagcgctgcg tagatcgcga cgccttcagg atgctcattc
     3601 agtgccgcga aatacgcgcc tggagtcaat ccctccgtcc tttcgaacgc ctgcccgttc
     3661 agtcgcatcc gagtggtgag cacaccaccg aagtcgagaa tcaggccacg gtatggggct
     3721 ggcaaagcgt cctccttgcc gatcttgcgt acgtgtacgc ggtcccccgg ccgcagggcg
     3781 acagggggac cgttgagtgc cctccccaga gggagagacc cccagtatcg cctctccccg
     3841 acgcacgtgg gcctacgctt gacacgagtg ccctgtccac tacggcgaac ggtcaaccca
     3901 tggtgtatga cggagagttg ttcagcatcg gccaacggat caagtggtgg cgtgagcgcc
     3961 ggggcttgtc ccaaaggatg ctgggagacc taatcggcag gtcagagaac tgggtctaca
     4021 agattgagaa cgatcggatg ccgctggacc ggcttccgat cctgatcgcg ctgagtaagc
     4081 agctgcgatg cagtctggag gacctgacgg gcggatacgt atccggaatc gttacggcgg
     4141 gcacggagca cgagcatgtt ccgctcatcc gacaggccct gtcgctgccc gcctctctcc
     4201 ttccgcagcg aatcgggtcg gtcacctccg acgacttcga gtcgtcggtt acggatgcct
     4261 ggaaggtcta cgagacgcag gctgaggacc ggtaccgcga cgtcggcgag cggctgccca
     4321 ccctcctgcg gcagggacac gccgctctgc gcgacgcctc acctgagcac gagggcaccg
     4381 tcctccggca gctcatcagc ctctacagcc tgcaccagat ctggcttcgt cgcgtcggtg
     4441 aaccgaccct cgcccgcatt gcggcggacc gcagtctctc cctcgcggac aacgccggtg
     4501 acccggccct cctcgcggct gcggcctgga gcctggcctg tgtcctcact tccgctggag
     4561 atgtggaaga cagctacgaa ctcgctcggc agaccatcgc ccagtgccgg ccgaatgacg
     4621 actccgcccc tgagcactgg tccgcgtacg gcgcgctgca cctgcaaggt gctgtagccg
     4681 ccgtacgcgc caccaagggc ccgagggcgt gggacctgta caacggagcg aagcgggccg
     4741 tggaccgagt cggcgcagac ctcaaccatt ggcacacgtg cttcgggccg accaacttcg
     4801 ctatgcacga agtgcacttg aaggcggagg aaggcgacac cagcgaagct ctccgcgccg
     4861 ccgatcacgt cgctgtcaac gaagaggtcc cgctcgaacg tcggacccgg tacctgatcg
     4921 aggtaatgaa cctcaaccgc atccagcggg acgactacgc gacggtgcac attctcggca
     4981 agctgttgaa gcagtcgccg gaggagatcg tgttctctcc cctggtcagg gaggcagtgg
     5041 cagacctgct gaagcgcgaa aagccgatgt ggcgcgacga cctgcgtgcg gtagcgaagc
     5101 acatcgggct cgccgcgtag gcatatgcca accctgagcg ttactcagcc ctgatttttt
     5161 ctcaggggtg ggcctctgaa gtggccctac gtttacgggt catgacgaca agtcacgctg
     5221 agacggaagc tggcgcggcg cccttaccgc ccgccaagcg ccacctccgc cttgctcgtg
     5281 aggccgaggt cgcgcacacg gaggccggtc gtttcgcggt ccctctcgac ctgcacgagg
     5341 ggaccgcgga gcccgcgccc cttccgctgg tcctgacggc cgatgaagtg gttgaccttc
     5401 acggcaagct cggggcgctc ttccccattg cggaagggaa ggcgcgatga ccgcgcgaac
     5461 ccccggcgat cgagcacgcc gccgcaatct cgccgacgca tccattaccc ccatgcccgc
     5521 cttcgccggt ctgctccggc gcatcccggg ccagcggcac cggaccaacc ccatcgcctc
     5581 gctcgaagcc cccgctcctg ggcacgaggg cggatcacgg atcggaacgg agcggtgaac
     5641 ggcccggcgc cgcagcgccc gaccgcgcct cgccccaacg gcttggtgaa ggagaacttc
     5701 cccatcacca agcgctctcc tggcgaactc cccccacccg tagacgaatc ccgcgttcga
     5761 gccatgaggc acgtgacccg ggaacgcctc acctctcgcg gtctgacctg cgtcgccgac
     5821 gatgcaaccc tcatcgtctc tgagctgatc accaacgcca tcctgcacag cggcggaatg
     5881 cagatccagc tcacccttga ccttcgcgat ggcgtcctgt gcatccgcgt ccacgatggc
     5941 gtgacagggc cccgccccac ggcacagacc cccgacgacg acgacgaaca cggtcgcgga
     6001 ctggtcctcg tgcaggagat cgcccgaagc agacggggcg cgtggggtgt cagcgacaac
     6061 ggcgccacca cgtggtgcga gctgagtttg gtggcgtgct gatgacgaac accgcattac
     6121 gcgactgggc gacgagcccg gagaccatgc cggtccgcgt taaggacccg acggtcccca
     6181 cgaccccttg gactcctcca cacgatgagg agaaggcccg gcggtacctg agcgcagtgc
     6241 gcgagtgggc aagcgtggat tggaacgagg tgttcgacga cctcgacacc atcctgcacg
     6301 gcgaggaaga gatcagccac cacgccgcgg gcccgtccgg cggagcacca ttacccaact
     6361 acaacgacga tgcccgtact cagcgcttcc tcatggcgct caagctgctt gtagcccgtg
     6421 ccttgcgaga ccaagccgac aagaagcacc cggacatcgc cggtctgatc ggacaggccc
     6481 gcacactgcg tgccgaggta gtggccggcg acgcgggaca gaccatcgga ctcgttcgga
     6541 agctggcgcg gctcaccctc gatctcgccg agcttttgga agaggccggg atcgttaggg
     6601 ggctggtcga gtgctaacga ccactaaggc ttcgacgcgt tcgttcgtcc cttctctctg
     6661 ctctgccgag gaggcgtacg acttcgagca cttccgggac cgccttgccc ggcccgaggt
     6721 ccttgctcac gccgtcgcgg tatgcgtctt ccgggcacca ctgcttgccg tgccggtcgg
     6781 tggcccgcgt cgcggcggat atatgtcctt cgatctgctg cccctggcaa taggagcacg
     6841 cggccttctc acgaaccgac cggggtttcc gaacctccgc gtccggtggt cgccgtaccg
     6901 cgatacctgc cacaccgtcg agtggggcga tcccgctccc gagtggtggg aggacgacgc
     6961 ggtcttcggc cggttctacg gctacagcga ggcagccatc accaccttcg tacgccagca
     7021 cccccggcct tctccggcgg tctccgttcc gtgttccccc acggccccgt agtcgccgag
     7081 ggagagccct cttcccgcac cgcacccgag aggacgacga gcaccatgtg caagcacaac
     7141 ccgccgtgtc ccacggccga cgcctccgac cgagaggcag cgcggcccgc tgcggcccac
     7201 cccgaacagg gttgggggtt gctgtgcaac ggcgtcctga tcttcgatga caccggccaa
     7261 ctcctgccgg acggacggat cgtcaaaccg catcggtccc tgctcgccct ccagacgatg
     7321 cggaggcccg gatgagcgtc atcgatgcca gccgccgacc cgcgctccag gtccccgaag
     7381 cagcctccgc acggttgcgc gtcgggtcct acaacgtaat ggacggcgga caggatcgct
     7441 ggtccggaca gctgaggctt ctggcatccc tggacctgga ccttctcggt atccaggagg
     7501 ccaagcactg ggaccggacg gactacgccc gagtccacga aactgctgag gcattgggga
     7561 tgcagccgct gttcgctccc tcccggagtc acggctgcca cctcgtcctc ttctatcgct
     7621 ggcctcggat acagtgccgc cggtttcggg ccgacatctc ctgcgggcgc tttcatcacg
     7681 ccgcatcaag agcgcagttc acggtcgacg gcgtcgatga acctctctgg gtcctccata
     7741 cacacctgca ccccttcagc ccggcggttc gcttgacgga ggccgggtgg ctgacggagt
     7801 acgccaatcc cgaccggctc gcggtgatca tcggggacct caacaccggt ggactcatgg
     7861 acagggaccc ggacgactgg gatcaagtgc ccgcgcacct ccactcccgc caccggctcg
     7921 tacttcctga cggcagttac ggcggcagcg accgtcgtgc gatgagtgcc ctgacgaaag
     7981 cggggttcgt tgacccgccg gaacagctgg gcatggagcc accgcgtacc gccggccact
     8041 ggggtcgcgg tagtgagccg tacgaccgcc ggtcggactt tgtgctgctg tcacgccgcc
     8101 tcgctccagc tgtccacgac caccgagtag tggacacggc cgaaacccag cgtctcggcg
     8161 accacctccc ggtgatcacc tccgtagacc tcgtcaggag gaagccacga ctcctgtaag
     8221 aggcgccacg tagaccaccg cccggcggcc cggatgtaac gggccggatc gtcgggcggt
     8281 tacaaccccg gcgcggggct gtcgcctcgt ccctgactca cgagcccctg cggctccgcg
     8341 ccggtccata gatccgctca accatgctcg gcacaactcg ccgaggagga gactccgcgt
     8401 ggataacgcc cccgatttga cgaccagcac ggaacaaggc gccgccaccg agcagcagct
     8461 acgcgacacg atggtgcaga agctcatcga ggccggggcc gcccgcagcc ctcgcgtcgt
     8521 ggccgcgttc cgcaccgttc cccggcactt ggccaccccc gaggtggaac ccgccaagac
     8581 gtacgaggtc gagaccgcca ccatcaccaa gaccgacgag cacggcgtgg acatcagctc
     8641 cgtgtccgcc ccgcggattc aggcgatgca gatcgagcaa gccgcgatcg agccggggat
     8701 gacggttctg gagatcggct caggcggtcc gaacgctgcg tacctcgcgg agatggccgg
     8761 cgagaacggg cgagtggtca ccgtggacat cgacgctgat gtcaccgctc gcgccgaacg
     8821 gttcgtggct gccaccggct accggaacat ctccgtcgtc acaggcgatg ccgagcacgg
     8881 cgttcccgaa cacgggccgt atgaccgcat cgtggtcacc gtgcaggctg ccgacatccc
     8941 gtccgcctgg gtcgaccagc tcacgaacgg cggacggctc gtcgttccgc tgcgtatgcg
     9001 cagcatgacc cgcacggtcg ccttcgtccg cgacggcgac cgactggtga gcgacgggtt
     9061 cgagcagtgc ggattcgtgc cgatgcgcgg agccggcgag aaccggatgc gcctggccgt
     9121 tctgcacgac gaggagggcg cggaagtcgc tctccgcctg gactcgggcc acgccgagcc
     9181 cgacacagaa gcgctgcgag ccgcgctgcg atccccgcgg tccgaggcgt ggtccggagt
     9241 gacggtcggc ggcgaggagt cgaaggaaca cctggacctg tggctcacga ccgctctgga
     9301 caacctcccc atcatggcgg ccaaggtcgg agcccggcag cgcggcatcg tcgctgccgc
     9361 ttccccgatc ggcctcccgg cgctcgtcga cggcggcagc ttcgcgtacc gcacgacccg
     9421 gcccaccgat caggaagacc gctacgagct gggcgccatc gggcacggac ccgacggccg
     9481 aaaggtcgct gagcgcctgg tcgaagagat ccaggcgtgg aacgacgggc accgcagcga
     9541 ccgtgcgcac attgaggtct acccggcggg cacgcccgac gaccgacttc ccgcaggccg
     9601 ggtcatcgac cggccgcaca cgcgggtcat catctcctgg ccgtgacgcc ttcagcgttg
     9661 ccgtcaggtg gcaccaccag cacgttccgc acagtccact gatccctcaa ccccgaggag
     9721 acgcacgatg gcaccgcaga tcaccaagtc cctgccgcag accggaacgc cgttctcggc
     9781 cgagtccggg tcggacttcg acctgaacat cgagaccgtc tcggcactgc ccgtggtcgg
     9841 agccctgctg aacgacaccg gcgacggctg cacgtccacc tgccagtccg cctgctcgaa
     9901 cagcacctgc ggctgaccgc agcaccccta tccggggcgg gcgggccagt cggctggtcc
     9961 gcccgccccg ggcaccgcac ctgtgaagga gggcattgac atgtatcgag cagttgacgc
    10021 gagcatgatt agaacatcgg tgtttccgct ggtgggtctg ctgccctcct gccccgcgcc
    10081 cgtcgcggac ggggccgccg acgcggagaa ttgccgccag tggatcaaac aggtgtgggc
    10141 ggacgacaca gtcgtcagcg ccgtcgaaat cgccgccccg gtcctggccg ccgccgttcg
    10201 caaggtcatc gacggcaagg ctcgtcggtc gcgcatccgc cggaccgccc attcggtgac
    10261 ccgctacctc ttgcgcatgc agttccgcgc aacgcccttc ggcacgttcg ccggccccac
    10321 ctcggtccgc ctgggtccgc gcaccagcat ccgttgggga acgcagcaca cggcattcgc
    10381 cagagccgat gcaacctggc tacacgactt cgtcaccgcc ctggagcaag acccggagat
    10441 actgcgtcac cttcacatcg ttgccgaccc cacgaccacc gtgcgcgggg cgacgatatc
    10501 cgtctcctgc cagcccggtg ctgatggccc aacggagacg accctccgcc gcaccaaggc
    10561 cgcagagctt gttctgtccc tcgcgcaggc tcccacgctg gtcaaagacg tcgtggcgaa
    10621 gatcaaagcg gactaccccg acacggcggt gacgacgatc gaggggatgg tgcgcaccct
    10681 tgtggcgcac cgcgtgcttc tcaccaacct tcccgctccg atgacccgtg atgatgccct
    10741 cggtcacctg gtcgatcagc tcgaccggac ctcccgcgcg ggagcccccg actcggccgt
    10801 acgggtccgg gcggagaaac tgcgccacgt ccaccagctt cttcaccagc acgatcacgc
    10861 tcatcccgac gaacagtgca ttcttcgcgt ccaggccacc acggcgatga accagctcac
    10921 cggggtcacc gagggcagcc ttgccgtaca cctgcgaccg gactgcaaca tcgttctgcc
    10981 ccatcaggtc gccgccgagg cgagccgcgc cttggacgtg atcggccgta tcacgccgta
    11041 cccgaacggc accccggcat ggcgcgacta cctcacccgc tttctggagc gctacagcac
    11101 gggcaccgta gtgccggtac gggaactcac cgatcccgac accggactgg gcttccccgt
    11161 cggataccgc agcaccgtgc ttccgcggcc cgtccttgca acgacgcctc gcgacgaaca
    11221 ccttctggca ctggttcagg aagccgccct gaccgaccgc cgcgagatcg tgctcaccga
    11281 ggacgacatc gaggccctgt ccaccggcaa gcccagccag gttcctgcgc acatcgagtt
    11341 cacgttcacc gttctcggcc agtccaagag cgccttggat gagggacgct tcaccctctc
    11401 ggtagtcggc ctgtcgctcg cggccggcat cacgaccggg cgcttcctcc ccaccctcga
    11461 accgtcggac ctcgaccggg tgaaggccgt tcacgccgcc ctgcccaccc tgaccgaggg
    11521 cgctgtccgc gggcaggtgt cgggcccacc gctgaaggtg ccgatcaaca acgtcagccg
    11581 ttcgcccctc gtcgcccccg agctgctgtc catcggcgag cacaaccccg acgccacttt
    11641 gagccttgac gacctcggtg tggtctcaga cgcagtccgc ttctacctcg tctcgctgtc
    11701 caccggccag gtcatcgagc ccaccgtgat gaacgccgtc gagctgtcca gcagcaccca
    11761 cccgctgacc cggttcgtct gcgaactgcc ccgcgcccac acggcggtcc tgatgccctt
    11821 cttctggggc gccgcgagtc agcttccgtt cctgcccgag gttcgggttg gccgtaccgt
    11881 gctgtccgcc gccctgtggc ggctgcgtca ccgtgacttc ggagacggga acgactggaa
    11941 cgagcggttg atcaactggc gttgcacgta cggccttccg cgcaccgtgt acctcggcgc
    12001 cagtgaccaa cgcctccggc tcgaccttga cgaacccgtc caccaagaac tgctgcgcgc
    12061 ggaattgaag cggcacggca aggccgtcct gcacgaggct ccggaggaaa gtgccttcgc
    12121 atggctcgac cgggcgcacg aagtagccat gactttcgca tccgaccaag accgccgtcc
    12181 cgctcccacg attcggtcct ccacagcccg gaatgtcggc aggatgcccg gctcctcaca
    12241 ctgggtgtac gtgaagctgt acggcagcac ggcccgagta ccagaggtgc tgaccggcca
    12301 tctcccccgg ctcctgcggc atggatgggg tactccgccg tccacatggt tcatccggta
    12361 cgccgaccct gaaccccata ttcgccttcg cctacgcctc cccgggccgg gggcgttcgg
    12421 ttccgccgca caagccgtcg ccgagtgggc cgccgaactg cggcgggagg gtctgcttca
    12481 ccgggtgcag tgggacaccg accactccga gaccggtcgc tacggcacgg gccgcgcgct
    12541 ggaggccgcg gaggactact tcgtggccga ctccgcggcc gccgtcgctc agctggccct
    12601 cgtggtgccc gccgacctcc gtcccgccat cactgcggcc tcattcgtag acatcacctc
    12661 gggattcctc ggctccagca aggacgcctt cacctggctc acccaacatc tcctgcggag
    12721 cgacggagga ctcgtccccc gcaacattca ggccctcgcg ctgcgtctgt ccaaacccga
    12781 cgcacgcaac gtcctggccg acttcgacgg cggtgatgcc gtggccgatg cctgggagat
    12841 gcgcaggcac gcgctcgacc gctaccgcca gacgctgacg ggggacgcac cggatgccgt
    12901 gctgccctcc ctgctgcaca tgcaccacaa ccgggccgca ggcattaatc cggcagcgga
    12961 agcgacctgc cgacggatag cgcgagctgc ggcccattcc tggactctca tccccgaagg
    13021 agaggcgtga ccaccgcccc gccggccacc gacacagcca cccgacagtc cctcgcacat
    13081 ggccctctcg gcgtcgcgat gctccatatc gagcgagccc gaaacggagc gggcgactgg
    13141 cgcgacattc accgcatcct tgctggggcg ggcccgttga tagacggcgg ggacgccaac
    13201 ctcttcctcg gagcccccgc gatggccttc gtcctgcacc tggctgccga cggcaccgac
    13261 cggtacgccg gtgcactgca caccctcgac ggcgtagtgg cctcgcacac tcagcagcgg
    13321 ctcgccgccg cgcacgcacg tatcgacgca ggccgccgtg cgacgttcgc cgagtacgac
    13381 ctcttccgcg gcttgaccgg cgtaggtgcg ctgttgctcc gccgtcagcc gcacggcgcg
    13441 gaaatgaagg gtgtcctgga gtacctggta cgtctggtca accccgtccc ggatgagtca
    13501 ggtgcggccc ttccgggttg gtgggtcggc cacgcaccgg ccagtgacaa gaccgccacc
    13561 cccggcggcc acgcgaacgc cggactggca cacggcatca ccggccccct tgccctcctc
    13621 tcactggcca tgcgcgctgg catcaccgtt gacggacacg aggccgcgat ccgccgcatc
    13681 tgccggtggc tcgatcagat caggcaaagc gactcacgcg gcctgcgttg gcctcgctgg
    13741 gtcagccacg gtggcgtctc tcccgcgctc ccggcgacgc ccggttggtg ctacggcacc
    13801 ccgggcctgg tgcgcgcgca gcagctcgcc gccatcgtcc tggaggacgc ggatcgcaaa
    13861 cggatggtcg agcgggcgct gacgtactgc cttggcgatt cccaccagct cgacaagatc
    13921 gccgaccgcg ggctgtgcca cggcttcggc ggtgttctgc gaaccgttca gcgcgtagtc
    13981 gaagacgccg acacccctgc tgagtacggc agccggttca gtctgctggt ccagcggttc
    14041 ctgacggcgg atgtcccgga gggcggcggc ttcctggtcg gcaaagccgg ggctgccctc
    14101 gccttccaag atgccgaagc gggcggctct ccccaagggc agtgggacgc ctgcctcctg
    14161 ctgacgtgag aggagcgact gtgcgccata cggatcatat ggaggacgcg atcctggcgg
    14221 ttctcggtgg ggcctccgta gaggaaacgg ctcacgccac cgacaccggg gccgcccaac
    14281 tgtccgaagc catcgagcgg tacaaggacg ccggccgggc tgcgctcgac gccgaaccat
    14341 ccggctggca ccagatgaac atccgcttcg cggactatcc cagcgccgat cgcacgttcc
    14401 gtgcgtacct cacgcccgcc ctgcggagct atccagtcgg cacctggtgg ttcgtgcgca
    14461 agtaccccca ttggcgattg cgcttctacc cagccccgaa cgcatcgccc gaggatgctc
    14521 tccgccacgt caccgaagcg ctcgacagct cggtctcctg gagcgtgacc aaggagtgga
    14581 ccgcgacccc gtacgagccg gaggccatcg cgttcggggg tccggttggg atgccgctcg
    14641 cacaggaact gttccacgcc gacagtgtcg gtgtgctcgg ctacctcggc gtcgcggccg
    14701 acggaagtgc aagaacactg gatgccaagg cgacgtccct cgtggccatg acgttgctga
    14761 tgcgcgctgc cggtctggag ttcggtgagc agggggacgt gtggggacgg gtcgaagaac
    14821 gccgtccgct cgctgaggac gtgtccccag aacaggtcag cagcatggtc gaacccatgc
    14881 gccgcctcct cctctcggat gcccgtcccc tgctcaacgc cggagacctc gcctgtgtac
    14941 ggccctggat cgagggactg gagcaaggcg gggaggcgct ggcggacgcg gccggcagcg
    15001 gcaacatcgg ccttgggaag cgaggcatcc tcgcacgcca cgtcctcttc cactggaacc
    15061 gaatgggctt caccgtccgc caacaatcca tctggtcccg tgcagctcgg gaggccgtcc
    15121 ttggccaatg aactggccgg agaaccacac ctggacgacg ctatcgcccc tggcaatccg
    15181 atcaggacac acgagaaagg gcatgccatg accacccctt cacagccgag acgatgggtg
    15241 agcctcgggt tggtgttcgg gggcgccacc ccggtctact cgatcccgca gcccgctccc
    15301 ggcccctcgc gttcccccgt ggcgcccgtc ggtgaacccg atgacgagaa cgccgagaag
    15361 ctgatgcgtg aagcgcgcta caggccgaag gtgccgtacc gcggtgctcg ctcgatgcct
    15421 tgggatagcg agtgtatgga ctgcggggca cctcgcaggc cctcgcttca ggatgttgag
    15481 cgcggtgttc ggtgcaagca catccggcgt aggtccggcg catgaggcgt gtccccgtga
    15541 ccgcgcagag cgcggtgttc cagtgcaagt tgtgcccgaa caacgggacg gaccggcatt
    15601 tccgaggtgt cggtgcgcgg atggctgcgt atcgcgtgtg ctactcgtgt gacttctggc
    15661 tgatgtgcct ggggtacgcg atgctcggcg accaagaccc ggacggccgg cgtgccctcc
    15721 ggatcgatgg cgtccattac ctgtcgtgga ccgaggagca ggggttcccg ccggagatcg
    15781 gctacgtcgg ggatgaggag tcccgctacg tcctgctcga cgatccggcg ggcaccgtgc
    15841 acgtgacgcg gcgcctctgg ctcatgggca ccatcccgga tgcgctccgc gaccggatgc
    15901 cggacaacgc gattttcgct ccgccgtcct aggaaggtac ggggccctcc tacacaggcg
    15961 gtgcgtcgtg agtgctgtcc ggcggtacgg gctgcatgtg gtccacctcg gttcgcttgg
    16021 cgtacgggga ctccggtttc ggagacgagg gcacctcgga ctcatcggta tcgacgtgct
    16081 gacgcccgtg ctgggctcgc agcctcgtct cattctggag gccggagacg cggtggtctg
    16141 cgccgcgagc cgtgctgcga gccttgatgg cctcggcccg gagctgtttg gctgcttcgt
    16201 cgtccttggc cttggcccgc cgaagcagcg tggccttctc ctgctgcggc atgtcagctt
    16261 ccgtcagcac ggcttcgtac tcgttgacgg gtccggcctg ccgggtgatg tcctggagcc
    16321 gcgcgtccat ctgccccagc tcctggacgg tctcctcacg ggtacgcaga agagcttcgc
    16381 ggtctgactc gaccgcagca cgctcttcgc cgcggagtgc cgcccgtcca aatcgacccg
    16441 tcgcagccag ctgctggtca agcccctcga ttcgggcctc ggtgctgttc agtcgggtgg
    16501 tgtgttccgc gatcgtgccg tccagcgacc ggacttcccg gatggccacg gcctgctcgg
    16561 caacgtcctg atgccggtgt tgaagcgcga gcgacctggg gcctgcaccg gcagcagcct
    16621 cccgttcggc acggtcggcg gcggcttccg ccttgtcggc cgccgccgtt gtggcgcggg
    16681 cggcggcggc tgccttgcgc acggcgtcac gcaatgctgc gttaccgagg tgagcgtatg
    16741 ggcgggcagc cgtcggcgcg ggttccgaag gtgtggccgg tgccgggatg ggtgcggtgt
    16801 tcgccgctgc ggggcggtcc tcgtgctccg gagcctcttc gggagtgtcg gcgtcgtggt
    16861 gctcgtcagc gccgggggcg cgcgggatcg ggaggtccgc aacggcctgg cggacgtgtg
    16921 cggggacggc gttcttcggg agttcggtga ggatcatgcg ttcctcggtg ccgttctcga
    16981 tctcgcggat gaggcccgcg acggcgcggt caagctgttc ttggtcggtg agtgcgtcgc
    17041 cgtggcgggc gcggtcgccg tcggtctcgt agacggagag cggcaggaac aggtgggact
    17101 cggccctgtc cctcgacatc atggtgtaga gggcgttcgc ctgggcgccg ggtccgtaga
    17161 ccagtgcctc ttggacggtg aggccctgcg acttgtggcc ggtgatcgcg tatccgaggc
    17221 tgagcccgcc gtgtgcgatg tagtcggcat cgacccattc ggcgacgtca cggtgaccat
    17281 cggcggtctt ctcccgccac tcgaccagaa cgcggcgttc ctcgtccacg gtgcgcacga
    17341 ttccgcggta gccgttcagg acgtcttcgt tctgccctcg gctcttcttg ccccggtagt
    17401 cgttgacccg taggagaacc tggtcgccga cggacagggt cagctcgccg ccaccgggca
    17461 gcgcgtatgc gtgctcggga ccggtgaggt cgccattctc cttccgcagt gcacgggcgc
    17521 cggtgttcag ctcttccacg atctcgttgg tggcggcgag catgaggagc tgctgcacgg
    17581 cggtgtggtc gtcggtgtgc gcggcccgct tgtcggccca gacggtgagc atcgcggcga
    17641 gggcggtgtc cttgtccgcg agagcgtgca cgcggccggt tccggcgaaa gtgcggagcg
    17701 attccacgcg gttgtcgtcg cgccagagct ccagtgcccg gcgctcgacc atgtccttct
    17761 ggcggaaatt ctggctgagg gtgagcccgc ccacgaggtg gtgcacggcg gcgaagctgc
    17821 cgccgatgcc gggcgagtgg agctgcttgg ggtcaccgat gccgacgacc ttcgtgccgg
    17881 tttcggcggc gtgggtgagg agttcggcga tgtcgcggtc atcgcacatc gcggcttcgt
    17941 ccacgaccag cacgtccacg ccggtgaggc cggagccgcc gttgcggatg ccggtcaacc
    18001 aggacgcgag ggtgcgggac tcgatgcccg cttcggcctt caggttcgcg gcggcgacgg
    18061 cggccgtgct cgcgccggcg atgacaaggc cgtgggcctc ccatgcctgt cgcgcggtgt
    18121 ccatgatcgt ggtcttgccc gatccggcga tgcccacgac ggcgtcgatt ccgtgcccgg
    18181 ccgtgagcag ccgttcgagg acggcacgct gttcgtcgga gaacgtgaag ctgccgccgt
    18241 gctgggcctc gacggtggac agcgtcatgt cgaccgtgtc gctgctgacg acggcggcct
    18301 gagtgctgag ccggttcgtg gcttcggaga cgatcagcgc ttcggccgcc acgacatcgg
    18361 ccgtggtgta ccggtcggcg tgcgtgaagt gctgggcgcc cttggggttg agctggaccg
    18421 cgtatccggc gtgccggagt acggagttgg tgagctgttc ggcctcggcg gcgtcaccga
    18481 cgccgtatgg gagggcgtcc agcacggcgg cgatggcggc ggcgtgggtg aactccttgg
    18541 agtggctggt caagccgttc ttagggtcga agacctgggc acacagctcg cccagagtgg
    18601 ggttctggtc tgctcggtcc tgttccatcg cgctggctgc gatggcgtcg gggtcgtctc
    18661 cggccgcgcg gccctcggcc tgccagtacg cgcggagaac atcgtccccg accccggcgg
    18721 cctcaccggt cttcgcggcc ttggacgcgg tggaggcggc ggtgcgctcg cgggtcgtgg
    18781 cgctgtcgta gtcgatgccg agtttcgtca gcaggtcccg gacctggctg tcgcgcttac
    18841 tgaacagccg aatcgtggcc tcgggaatcg ccgcgatctc ccatgctccc gtccgctcct
    18901 ctcggcggaa gctgatgccg aactcgttgg tcagctcgcg gcggatgcgg gcgttcatga
    18961 gggactgggt cgcgcgggtg tgccggtgaa ggtcgcggcc cccgctggcc atcgtggacc
    19021 acttgccatc ggtgcccttg accatgttgg cgagggtgaa gtgcaggtgg aaatggggat
    19081 cgccgtacgg ggcaccatcg acggggcggg cggcgcggtg caccatcatc cagccggaga
    19141 acccgctcgt cttcacggtc tcggcctcgt cgccgtcgcc gtgacggccg cgcatggcgt
    19201 acgccgtcca gcgctccaga gcaccgatgg actcgcggcc ggcggccgtg tagatgccct
    19261 cgacctgggc ggcgatctcc tcgggcgcgt acgcgagaaa cgcggacttc gacttcgaca
    19321 agtccagcgt gacgtccgcg ccacggttac cgacctgcac gcggccttcg aggagggcgg
    19381 ccttgatctc ctcggcgtcc cacacgtcct cgggcgtgag ccctgccgcc ttggccatcg
    19441 cgacggcttc gcggacatcc atcggcaggt cgcgaagacg gcgtgcacct tcaccttcgg
    19501 tctgggcgta ccggcgtttc atggacacgg cgtcgaacag gtcagcgggc tgctggccgg
    19561 tctcggtggc gcgggcctcg accgcgcgca ggagtgcgcg ggcgtccagg tggccgcccg
    19621 cctcggcggc gatggccttc tcaaccgtgt cctcgccgta caggtcgacg gcgttgatgc
    19681 cgacggcgtc ggcgagcttc agcaccgtgg aaatggggac gcggtgcgac tctccgaacc
    19741 gcttgagctg gctctccatc cggcgaaagg cgtcctgctt acgcttggag tccagcaggg
    19801 agacggggtt cacgctgcgt tcggcggcgg cgcggcggat ggcgcgggcc agcggggcgg
    19861 cggggagctt ggcggccggc gcgatggcca gcttcgggtc cacgagggtc tgcccggccc
    19921 gggggtcttc cccgagcatg aggcgccggg cggccgggaa ttgctcgggg gcgagggtgc
    19981 tgccgggcgt gatgtcgaac tcggtgagcc cgccgccgat ccagaccagg ggccgttcgc
    20041 tggcgtccag gtggtagtcc acctgtccgt cggcggcacg tgggggaagg gcctgttcgc
    20101 cgtagaggtc gcgggcgtcg agcccggctg cggcggcgac ttcgacggcg tcgaacccgg
    20161 tgaaccgcgc agcacccttg ctgcggagga gtccgcgggc gcggaagaag gcgcgcttgg
    20221 cctcgcggtt cgcgagcaga gaggcgacgg gggcaccggc ggcttcggcc ttcgcctcga
    20281 tggcggcaat aaggggagcg gcgtcgaccg ctacggacct cccgcatccg tggccaccgg
    20341 taaggcggta ctcaacctgc tcgtcggagg ggccgatcat ggtcacccat cccatcggcc
    20401 cgctcacccc ccgctctcat ccggtcagtt tcggtcgtct tggctgattg tatcgtcacg
    20461 aagtgacgat accttggtcc tctaaattca agatcatgct caacgagggg aaacctcggg
    20521 cactcggagc tgtcctgtga aggtgaacct tgcggattgc agcttcacct tgcggatggg
    20581 cctgcggatg gacgagctac cttgcgggca cctgcggtac cgagcgtgga cggcggccgg
    20641 acgagttgtc gtgcgcagag taggtgtcag tgacgcgcag ggttttgccg gccacccagc
    20701 gaacctttgg gggccgcgcc agcacggccc ccaaaggcgg ggcgttggtg ttcagctggt
    20761 ggtgtccttg gcgactcgga cgctgctgac cttgccggtc agctgggcca tggccccgtg
    20821 gccgttcgcg cgtacgccgg gaacgatctc ctggccgatc gggacctggt atcccgcgtc
    20881 gacgttgata cgacgtgtcg ggtccatagg gaacgggtcg gtcagcttgt aagaggccca
    20941 cgactcgtct tcggagccgg tggcgctgtt gtagatggtg atggtgtagc cgggctgtgg
    21001 gttcttcacg ctgaaggaat aggtgtcgtc gttgggcagc gagttgttcc tgaagtcgtg
    21061 gaggccgggt gtcagagtga actcgccctt gtagtccatc tcccctttct tcccgtagaa
    21121 ctcgatgacg ggcgtcgttt cgatgttggg catggtgtcg ctctccctca tgtcggcggt
    21181 ggtcgtgccg gcggctccgg ctgaacagat caagatcaca tcgacgctag cagcggacgc
    21241 ggcgtggcgg ctgtggttcc cgttctgcac cgcctcaaag gctgaaagtg ctctacagcc
    21301 tccgctgcga cccacacctg cctactgaca cggactcttc gtttccgctg ccataaccct
    21361 gcgcatccca ctgacatcaa ccctgcgcac gacacgagtc gccgtccgtc gaatccgcaa
    21421 ggtaggtctt cgcaatctcg gcgggcgtcg tgaagacaca cgcttcgtcc cgctggtcac
    21481 ccgcggccga cgccgcaacc tccagccgca ccagacagga gcggcctggt ggctcctgcg
    21541 aatcaggctc ctggaggagg atctccggtt ggactgttac ctctgtgcga ggtgcgcgga
    21601 ctgcggcgcg gtacgcgccg aggcgatatg acgatcggat gtcgacgcgg tacctgtagg
    21661 ccgctgagtc gttggcccgc atatggagca caccccgccc tcggcgcctc cccgccagtt
    21721 cgctgagttg tcgggcccgt actggatggc ccgggactcc ccggcgtagg agcccggacg
    21781 tcagacttcg ccaccgcaac tgagcgatcg gccggcaggc ggagcgggcc cccgatcggc
    21841 ggacggctcg tagtctctga tccgtcgccc tggcgccggg tcgagcggtc ttggttgggc
    21901 cctgcccggc cctccagcgc ctggcgacat gacgaaggtc cccctccgga tggaggggga
    21961 ccttcgtcat gtcgccggat ggccttgtgg ccgacggtta tgtgttccgg ggccattcgc
    22021 cgaacggcac cggtgcctga ccgtgcgctt cgcgtacggc ctcgtccgta ccgcatgtgg
    22081 tgcagatgag gacttcgcgg tcggtggtca gccgagaacg tgcggggcgt tcaccgagcg
    22141 ggccgccgca gcgcggacag cgggtgtcgg gcacgggtca ctcctcgggg tgctcgcgtg
    22201 cggacttgag gatcagattc caggtcgggc gggagtaggt cttctctgtc tggccctgga
    22261 gctgcgggat cagttcggcg ttcttcgcgc cggggttcgc cgcgatggcc tgccgggcga
    22321 gagtcagccg ctcgtctccc tggtaggggt aggccaggcc cttgcgaccc gcggtgcgtc
    22381 cgccggcgtg cccgcgaccc ttgcggtccg cgaggtactg ccacagccgc caccgcttcc
    22441 acttcgggcg gtccctcgtc gggagcttgt cccagtcgtc gggggcgggc cacccctcgg
    22501 gcgggttctt gacgtaatgg gagatggtgg cggagtcggc gaacccgcaa accttcgcgg
    22561 cttcggccgg gccgaccatc tcttcggggt caccgtcgag cttcggcggg ttggaggtgt
    22621 tcgcggcggc gcgctgccgc tgaagctcgt ggtgccacgt cgcccattcg tcgccgtccc
    22681 agtgcatgac gccgtcaacg gtcttggcag gcgggtgccc gttgttctcc cggtcgctcc
    22741 ataggttctg aagcgtgggc tcgctgatgc cgtggaccct gcgcaggtcc gcgcgtgagt
    22801 agagcgtgcg gctggtcttg cggggcacgg tcgcctcctg ttcttggtcg ggttgtggcc
    22861 gctgggcgcg gtcacagaat gtcgtctggc tccggggccg gcgtccacgt acggctgcct
    22921 gccggttcca gccgggtgag ggtggctatg tctgccaggg ggacggcggc ggcccagtcg
    22981 gcgcggccgg ggtggtcgac gggcaggttg agtacgaggt gccggccggt cggggggaag
    23041 tcctcgacga tgacgaagtt gtcgccgggg tcggcgccga tgctgttacc cctggtgagc
    23101 tgggcgatgt cgccgggctg gggacagtcg gggtgtcggt cacatagcat ggtgtggtct
    23161 ttctggtgag agacaccgac ggccagcgcc ttgttgccct tgtgcgctgg ccgtcatctg
    23221 ttgtctgggg tgcgtcgcgc ccaaggggcg cgcggccggt cggaggttgc ccgctccgct
    23281 gacggcggag taattaaacc acctttggaa tgagcgggcg gggccctggc tcggacgacg
    23341 gtggtcatca gaagagggct tcctgatctg cgggccgtcg gctctgggct cgcggtggcc
    23401 ggggcacatg gagctcgtaa cgggggcgct ctgcgtacgg cgggcggtgg gcttcgcggt
    23461 ggtgccggcg ccaagccaca acgggcgcgc cctgctccac ccatcccgcc ggataccggg
    23521 cgatgaactg agcccagcgg ctccggctcc gcggcactgc ccagcggtcc tcaaccgtgt
    23581 tgatcggcgg cagcgtcctc cagccgggga acgcatggtc gtgcgcgtcc tccaccgcgt
    23641 cgttgtcgcc gtccccgaac ccgccgccgg agtacacggg cccttcccac ccgcaggcga
    23701 gacacccggc gcggaactcc tgcttctccc cccggcggcc ggtcggccgg ctgcgggaga
    23761 gcagggtcgg ggcgtggtgt gcgggcgggt ccagctcgtg gccgaggtcg ctgtacgccc
    23821 cgccggggtg tccgggctgg atgtgccacg cctgcgccgc ggtctcgggc cggtggcggg
    23881 tccgcgcgtt gcgcactcgc cagtagtacg tctgccgcgc ccgtgccccg ctcggctcgg
    23941 cgacggtggc cgtcacggtg tcctgcttcc ggcggcgagc acttcgcgga gtgggtccgc
    24001 gagcacggcc tgttcgtcag gggcatcgag gaatcgcggc ccgtacgcgc ggcgcacggc
    24061 gcggcgggcg tcctggtggc ggtccagctc cgggtagtac ggcgatcggt cgagcacgtc
    24121 atagccgtgc tgggtgagca cgtcagcgat gagtgaccgg acatgtacgg ggtcgagggt
    24181 ggagaggtcg gcttctccgg gagccgcgag gagtacgcgg atcaactcgg tcgcgctgag
    24241 ccgggggtgg aggggaacgc tgagtcggtg gacgccgtcc cggctgggtg tggcggctcc
    24301 tcggcggctc ggcgtcctgg tggtgctgcg gtcttctgtc gtctcgtcca tcgtgatggc
    24361 cttcggtgac tggggatgct ggcggggcgt ccggggtcag aacagggcgt gttcggcgcg
    24421 ggcggctgcg gtgcggaacg cgcgggcggc gtcggcagcg gtacgtccgg gctcggcgct
    24481 ccacaggtcg acggcctcgc ggtgcagggc cttggcggcg gccgggtcct cggcgttgac
    24541 ggggtgaccg gtgagggttt ccgcgaggag ggcgaacgac tggtcgcggg cgcggtcgat
    24601 gcggtcccag tcgtacgtcc ggccggcggc tccccgcccg tggccggcgg cgacttggag
    24661 ggcgccgggg gccagcacgg caaggtggcg gtgcggccgg gaccgtcgaa caggcgcggg
    24721 ccctggtgga tgccgacgtg ttcgatgtgg cgggcggccc attccaggat cgcggcgggg
    24781 gtgtccgcga tgacgatgct ctcgggggtg tggcgggtcg gcacggtgct gtccttcggg
    24841 agggacgggg acggcggcgc gctgccgccg cccccggtcg ggctgctagt ggtaggcggg
    24901 gatcagtcgg cggaccttgt cctctccgat gcacccgccc ttgtggcggc gtgcgctggg
    24961 cggctctccg ttacggccgc gcagatgtga ccagaacttc ggcccttgcc agtcgcacaa
    25021 ttcacagctg aggaaccagt ggttatcgct gccagggaac ccggtgagga ctgcccgcca
    25081 gtggtgggcc gcgagtcccg cgaacgcgat ctcggcgccc tcggtgttgc g
//
