LOCUS       NZ_CP045178            25116 bp    DNA     linear   CON 25-NOV-2024
DEFINITION  Streptomyces tsukubensis strain AT3 chromosome, complete genome.
ACCESSION   NZ_CP045178
VERSION     NZ_CP045178.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces tsukubensis
  ORGANISM  Streptomyces tsukubensis
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8615214)
  AUTHORS   Cao,G., Zhong,C., Fu,J., Zhang,P., Liu,M. and Zong,G.
  TITLE     Complete genome sequence of Streptomyces tsukubaensis AT3
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8615214)
  AUTHORS   Cao,G., Zhong,C., Fu,J., Zhang,P., Liu,M. and Zong,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-OCT-2019) Shandong Medicinal Biotechnology Center,
            Shandong First Medical University, 18877 Jinshi Road, Jinan 250062,
            China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 01-OCT-2019
            Assembly Method :: SOAPdenovo v. OCT-2019; SPAdes v. OCT-2019
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 997.0x
            Sequencing Technology             :: Illumina HiSeq; PacBio RSII
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_009296025.1-RS_2024_11_20
            Annotation Date                   :: 11/20/2024 08:40:01
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,005
            CDSs (total)                      :: 6,919
            Genes (coding)                    :: 6,691
            CDSs (with protein)               :: 6,691
            Genes (RNA)                       :: 86
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 65
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 228
            CDSs (without protein)            :: 228
            Pseudo Genes (ambiguous residues) :: 0 of 228
            Pseudo Genes (frameshifted)       :: 76 of 228
            Pseudo Genes (incomplete)         :: 184 of 228
            Pseudo Genes (internal stop)      :: 10 of 228
            Pseudo Genes (multiple problems)  :: 38 of 228
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 05:10:03
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3387332
            Orig. end                         :: 3412448
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP045178.1.
            Bacteria and source DNA available from Dr. Guangxiang Cao.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..25116
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="16"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..25116
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25116
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:15116](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..15116
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    406..418
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 18.92"
                     /tool="antismash"
     misc_feature    complement(676..689)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.57"
                     /tool="antismash"
     gene            complement(1088..1876)
                     /locus_tag="GBW32_RS14330"
                     /old_locus_tag="GBW32_14320"
     CDS             complement(1088..1876)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007264538.1"
                     /locus_tag="GBW32_RS14330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_14320"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_077972715.1"
                     /transl_table=11
                     /translation="MTTAVTNSRHDLAGGHAAVAARARQVVKAYGAGETRVVALDGVDV
                     DIMAGQFTAIMGPSGSGKSTLMHCLAGLDTVTSGEIRLADTEITGLKDKKLTRLRRDRV
                     GFIFQSYNLLPTLNAIENITLPMDIAGRKPAREWLERVVETVGLAGRLKHRPTELSGGQ
                     QQRVAVARALAARPEIIFGDEPTGNLDSRAGAEILGFLRASVDDLGQTMVMVTHDPVAA
                     SYADRVLYLADGSVVDEMRSPSADQVFDRMKDFDGRGRTS"
     misc_feature    complement(2293..2308)
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 21.77"
                     /tool="antismash"
     misc_feature    2330..2344
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.96"
                     /tool="antismash"
     gene            complement(2473..3336)
                     /locus_tag="GBW32_RS14335"
                     /old_locus_tag="GBW32_14325"
     CDS             complement(2473..3336)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018959880.1"
                     /locus_tag="GBW32_RS14335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_14325"
                     /product="hypothetical protein"
                     /protein_id="WP_319789655.1"
                     /transl_table=11
                     /translation="MAIGIGVHIQSLPDGSTVTIKALSVRFPEGEVTIGRAIRELETAG
                     YLARRRVPLGGGRIATRTFFLDHPGAGAGAGAGAAAGAAGAAAVQAPVRAPVRARRTRT
                     AVTTPAPAPSEAPPPAPAPPPPPPPSPVRTKRTAPEPAPVSPAPEGPAADLLARLRVAD
                     TRLLLSEDDVHRLAPVVETWLTRAATPEQITRSLTTGLPIDATPINHPARFVEHRLTTL
                     RPPPLPPEPLSPTEGITPLPRVPLVTCDDCDRAFRSSDPHALCRDCRERRTHRERGGAE
                     WAHTAA"
     misc_feature    3317..3332
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.74"
                     /tool="antismash"
     misc_feature    complement(3492..3505)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: medium, score:
                     16.82"
                     /tool="antismash"
     misc_feature    3502..3518
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 21.11"
                     /tool="antismash"
     gene            complement(3936..4502)
                     /locus_tag="GBW32_RS14340"
                     /old_locus_tag="GBW32_14330"
     CDS             complement(3936..4502)
                     /GO_process="GO:0042546 - cell wall biogenesis [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014152025.1"
                     /locus_tag="GBW32_RS14340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_14330"
                     /product="SMI1/KNR4 family protein"
                     /protein_id="WP_077970088.1"
                     /transl_table=11
                     /translation="MAPSPLTVPEWRQFLSDYSAKFLASDLFREADAEGRSFLSEAQRE
                     ARWLGYEPAAEAAVLAAEERFGVRLPPTYRNFLLASNGCKDVGLIDLLGIEKIGWFSDM
                     TDLLDYWLSPGDGYLAEDLDKFERSLLISIDDGGSGGYWVLHADSAREDGEWTAYEWWP
                     GEGGDPERYENFATLVTSAADYVLS"
     gene            4869..5030
                     /locus_tag="GBW32_RS14345"
                     /old_locus_tag="GBW32_14335"
     CDS             4869..5030
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="GBW32_RS14345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GBW32_14335"
                     /product="hypothetical protein"
                     /protein_id="WP_179120241.1"
                     /transl_table=11
                     /translation="MATVGARGISSFTTTAFVVQPLDALTGPADPPAYAPLNTGPDYVA
                     VLRSLLAG"
     gene            complement(5286..6428)
                     /locus_tag="GBW32_RS14350"
                     /old_locus_tag="GBW32_14340"
     CDS             complement(5286..6428)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF038083.1"
                     /locus_tag="GBW32_RS14350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_14340"
                     /product="CU044_5270 family protein"
                     /protein_id="WP_077970089.1"
                     /transl_table=11
                     /translation="MNALFRNRVGATTPSPSSRPSDPAHEEGDGEWQEARDRSERAALR
                     ALVPPPAARLSPTRHAELRAHLMNEINDTAVASDPAKSAKSVGFAKSATPEGPAKSVKS
                     SKSRSSVGRSPAFGWLTPGRSMSLGAAAAVVAATVAGFALTGSSGQTAVAAPAPLKVES
                     SRATVPLATVAKRAAALADSPGDARRGTHRMEWALGLWDDGKHKPEEMPVDESRDRWNA
                     DGSGVVEDLKDGRVTHRTHKPAGSWEKLASFRSTPPTTVRGLADYLAKDNPDIHGSAYW
                     TMDTVEALLREWTPGPAQTAAIDGLLAEQSGLNALGPVKDRAGRQGQAYGVDFKGTVRW
                     TIILDEHTGRILGTELSSIKTDPEMQLKPGDVEQYDTYLD"
     gene            complement(6425..7150)
                     /locus_tag="GBW32_RS14355"
                     /old_locus_tag="GBW32_14345"
     CDS             complement(6425..7150)
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016471566.1"
                     /locus_tag="GBW32_RS14355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_14345"
                     /product="RNA polymerase sigma factor"
                     /protein_id="WP_077970091.1"
                     /transl_table=11
                     /translation="MTHSTHARLREGDPAALAEAFQEHADAVYRHALWSTGNWATAEDV
                     VSLTYLEAWRSRERLRPEETGSLRPWLLGIATNVLRNTARSARRHQRALARMPRGDTVP
                     DFADEVTGRLADAEQLAAAKAALKGLRRTEREVFTLCVWGELDYASAAEALGIPVGTVR
                     SRLSRARAKLRDSVRHPAARREDDTQGASGRMRDSVRHPAARRDDDTQGASGRELPGDS
                     GQIQRVDSIPARTTQENLA"
     misc_feature    complement(7184..7199)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.13"
                     /tool="antismash"
     gene            complement(7557..7823)
                     /locus_tag="GBW32_RS14360"
                     /old_locus_tag="GBW32_14350"
     CDS             complement(7557..7823)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="GBW32_RS14360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GBW32_14350"
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_077970093.1"
                     /transl_table=11
                     /translation="MTDEALKAKKALLNEMLDVDQSTLAFIKSEASAGGSGDCLEVAKV
                     QGKGYLLRHSILTDHLIPLTESEYVAYCKGVRAGQESLLPDSL"
     gene            complement(7816..8700)
                     /locus_tag="GBW32_RS14365"
                     /old_locus_tag="GBW32_14355"
     CDS             complement(7816..8700)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040183.4"
                     /locus_tag="GBW32_RS14365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_14355"
                     /product="DUF5753 domain-containing protein"
                     /protein_id="WP_077970094.1"
                     /transl_table=11
                     /translation="MALNPVANSARERFGAALQRVRLAAPRGDGPVKQIHVARALGQKT
                     YHRYSRIERGETWPKDKEWATICDFLQMDDVTRVRLETMRSEGLAIVESAWWIEFADDT
                     DPSLLQFVTNEQIANKIVTCAGSIVPGLFQIPDYGRTLTSYLGKSTMTQQAVERSVAFR
                     QKRRKVFDRPSPPVIEAIIGEGALHQQVGGPQVMGRQLDSLMDDATTRGVVFRVIPYEA
                     NAALAYPFHLLEFGEAERPVAAFDVMTGMAFRETPKEIRGLKHFVGDLKDLSLSPEESL
                     ERIGKIRREISSD"
     gene            8903..9145
                     /locus_tag="GBW32_RS14370"
                     /old_locus_tag="GBW32_14360"
     CDS             8903..9145
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024970.5"
                     /locus_tag="GBW32_RS14370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_14360"
                     /product="ATP-binding protein"
                     /protein_id="WP_077970095.1"
                     /transl_table=11
                     /translation="MCTTGHPASPTSAARCFARDPNSVPIARSWATAVCESYGVTDDLL
                     ETCKLLVSEAATNAVTHGGGDEFTVAICRDLWIEV"
     misc_feature    9035..9037
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    9288..9304
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 19.83"
                     /tool="antismash"
     gene            9304..9522
                     /locus_tag="GBW32_RS14375"
                     /old_locus_tag="GBW32_14365"
     CDS             9304..9522
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="GBW32_RS14375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GBW32_14365"
                     /product="hypothetical protein"
                     /protein_id="WP_143621367.1"
                     /transl_table=11
                     /translation="MSACMAGRPDDTVACALLVILSTAILTGLSSMMLAGARHSERHRC
                     QAKIDEERVGYHDFPDEYPLNPNTGPR"
     misc_feature    complement(9642..9655)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.81"
                     /tool="antismash"
     gene            9645..9839
                     /locus_tag="GBW32_RS14380"
                     /old_locus_tag="GBW32_14370"
     CDS             9645..9839
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR04363.1"
                     /locus_tag="GBW32_RS14380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_14370"
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_077970098.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 5.4e-17, bitscore:
                     60.1, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVQLEQPVAPEQPTATDTDTDEATDPFQLDITFIENTPATETML
                     MCSTGDNCGSSCPSACTTS"
     CDS_motif       9645..9770
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MTVQLEQPVAPEQPTATDTDTDEATDPFQLDITFIENTPATE"
                     /locus_tag="GBW32_RS14380_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9771..9839
                     /prepeptide="core"
                     /locus_tag="GBW32_RS14380_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="-5.30"
                     /molecular_weight="1995.2"
                     /monoisotopic_mass="1993.8"
                     /core_sequence="TMLMCSTGDNCGSSCPSACTTS"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MTVQLEQPVAPEQPTATDTDTDEATDPFQLDITFIENTPAT
                     E"
                     /leader_location="[9644:9770](+)"
                     /alternative_weights="2013.3"
                     /alternative_weights="2031.3"
                     /alternative_weights="2049.3"
                     /alternative_weights="2067.3"
                     /alternative_weights="2085.3"
     gene            10001..11956
                     /locus_tag="GBW32_RS14385"
                     /old_locus_tag="GBW32_14375"
     CDS             10001..11956
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006346484.1"
                     /locus_tag="GBW32_RS14385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_14375"
                     /product="lantibiotic dehydratase family protein"
                     /protein_id="WP_227025502.1"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 9.1e-19,
                     bitscore: 66.6, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_N (E-value: 1.1e-99, bitscore:
                     333.0, seeds: 73, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPPWPKPTAPLEHWRSWLAAVWADDTFRQAVSSASPDLSRQTQSI
                     IDGRSPKMRRVRRAALAIARYSIRYAHRSTPYGLFAGVALTEFGETAEVRFGDRNRAVT
                     RPDPAALDAAISAWEADAEGVADLDLCVNNLAQQRSGRIYVPSEGASEFSLALTPAVVL
                     VLTAARLPIRYSALADKLAAEFPTTTEHHRARMLAQLLEVRLLLSSLRAPATVVDPAGP
                     VPPVLRENLRNNQAAPDLRLDATVRLPEVVMREAETAATVLTRLATHPKGIPAWRRYAE
                     RFADRWGEGVEVPLELVTDPERGLGFPEGFGQVSEPPRPMIQRDRLLLELAGTAGIEGN
                     RSVVLSSAMVEQLEATVGKPVNTPPHLELGVQVQADSTHALNHGDFRLRVSTVSRSAGS
                     MTGRFWHLFPNVGATYADLPTVEPDAELAQLSFRAGRVSADLLTRAPQALPRVVSVGEF
                     RHRTEGVLFPLDLAVGIREGRLYLAEIATGTHLELLAPTALNLLWNNYTPPLARYLAEI
                     SRAGASQVTWFDWGAAWTLPFTPALRYRRSILVSARWKVRSRDLPGRTATRDEWAGRLH
                     AWMERFRVSDRVLLAEDDQRLPLDLRLDMHLDLLRTHLDASPIGVATLYDAPPPNADGW
                     IGGRAHNFVLPLMACP"
     misc_feature    10388..10390
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     aSDomain        10388..10639
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_GBW32_RS14385_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="3.70E-21"
                     /identifier="RREFam001.1"
                     /label="GBW32_RS14385"
                     /locus_tag="GBW32_RS14385"
                     /protein_end="213"
                     /protein_start="129"
                     /score="66.6"
                     /tool="antismash"
                     /translation="LCVNNLAQQRSGRIYVPSEGASEFSLALTPAVVLVLTAARLPIRY
                     SALADKLAAEFPTTTEHHRARMLAQLLEVRLLLSSLRAP"
     gene            11962..13026
                     /locus_tag="GBW32_RS14390"
                     /old_locus_tag="GBW32_14380"
     CDS             11962..13026
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.5"
                     /locus_tag="GBW32_RS14390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_14380"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_077970100.1"
                     /sec_met_domain="LANC_like (E-value: 8.6e-36, bitscore:
                     122.1, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTARPGTQDLSEGTLGVALLHIERGDLAAARSCLEEAVAGGVSAG
                     GNASLFHGAPALEFALSRAGHAGRDIHDTVDRIVDARLAAANRRRETGALPHLGEFDLI
                     RGLSGLGALLLTRGAASPLLEEVLAYLVSLARPVRIEGRELPGWWSEAGPNGAEMDGGH
                     GNNGLAHGIAGPLAMLSLAFQHDVQVPGQREAIEKFARWLDLHGGHYWTTRAHLDAFEP
                     PEPEPARQSWCYGGPGIARAQQLAALALDDPDRRKAAEDTVVHTLTHPFHLARITDATL
                     CHGWAGLLTLARAVAADSPAPERFSSLIGDLHRHLASDLDQLPKPGFMEGRSGAQLALD
                     GTNATDWTSVLLIT"
     gene            13062..15116
                     /gene="fxlM"
                     /locus_tag="GBW32_RS14395"
                     /old_locus_tag="GBW32_14385"
     CDS             13062..15116
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006346482.1"
                     /locus_tag="GBW32_RS14395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_14385"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_077970102.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.1e-17, bitscore:
                     63.2, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PCMT (E-value: 4.6e-42, bitscore: 142.8,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAFDDDENLPITHDTSWWHASVTFPGDVVSSEAAKFLAAALHDQR
                     FHFLRKDSGLRLRTERPSDDLCDRLIAQQLATGWVGGIYEPEFDAFGGPEGMDVAHEVF
                     CADSRSALFETGAPGARERCVMLLSAMIREAGLDPFEAGDVWSKLAALRPHVTPPIGRR
                     LDRSVSAMWRLMNADATRRPDAEPGWTERVATFEKAGRRLRRLTADGRLIRGLRAVLAH
                     HAIFAFNRAGVPAIEQAATAWLARQVAFAAWEETDVSSRRTTSMDLGLARLETTVTPVT
                     DPAELREILVDRLIDSGRLRSPAVIDAFRTTDRHQFLPGVDTETAYKEDAVPIKHDENG
                     EMISCISAPSIVATQLEQLGARPGEKILEGGAATGYNACLVGKVVGPHGHVWTLDIDQD
                     LVAGAETNLAQHGTTNVTVVLADGAVGLPEHAPYDRIQFTVGAGDVPVKLLDQLAPNGR
                     LVLPMRIRGSVSRSFAFERDGDTWKTVSCEMATFVPLRKGVCDDIYTLVPMDGEGNVRL
                     ETFSEQEVDRDAIRTVLDQKQAKIYTGVKFRQGDPWEWLYLYLASVLPNGLSRMPGQRS
                     GFTPHFGWGSMAALDGDSLAYLTIRESEDVEGRFWEIGVVGHGPRAAELADQVVTEIRY
                     WDKGWGNTAPEPIFHMAVGDARDKLTASEPRFVIDKTYSRLVVDWPRKG"
     gene            15121..16224
                     /locus_tag="GBW32_RS14400"
                     /old_locus_tag="GBW32_14390"
     CDS             15121..16224
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006346481.1"
                     /locus_tag="GBW32_RS14400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_14390"
                     /product="type I toxin-antitoxin system ptaRNA1 family
                     toxin"
                     /protein_id="WP_077970104.1"
                     /transl_table=11
                     /translation="MNLSMASRIPLVRRHKAPALPLDQRITHLTGLAVELSGASHHDLV
                     ARASGVLNYAALVASDVGIPDLAADLCWRQHQVFAGAGTLTEDIAVMSLMPLINISRLL
                     TREGDGEAAYDVLTRLYRAALKRGPVEIRGNTVDLSVLTATDADHRKVCQELWVTVLVD
                     GARALARIGRWTGAAEAMTAHRGIGNRLLDGRQIMIMSLLERGLYQQARDTIESSVLTE
                     PWENTVAALLHVCCRPPGSRTPQSELDHALQEATALLAPPDASTVVFQARVGLTALELV
                     PDHTARPVVPLREAIANMASRDAYAAREVLNHPVLSPRLACEQRKALTAVISASGLGAG
                     ELPQAHMNALTESVEKAEAALGRLLYT"
     misc_feature    15178..15180
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(16319..17326)
                     /locus_tag="GBW32_RS14405"
                     /old_locus_tag="GBW32_14395"
     CDS             complement(16319..17326)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010984986.1"
                     /locus_tag="GBW32_RS14405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_14395"
                     /product="cellulose-binding protein"
                     /protein_id="WP_227025131.1"
                     /transl_table=11
                     /translation="MSSVSASPHGFAPVPPSVRSRGYRPGQVDPYVSELSGSRDAAWER
                     AARLTVLAKEMRGEADRLRDVVAKLAPQTYEALGERAVRILALGEEEAAALWEAARVAG
                     ASVVDAAGRDAADTGERARAHAGAVLAEAGGWADERDAAARAAADEIRKAARRDVKEWR
                     GESLAVLRDTRQRCEALLAAQEKEQADRWEAAEGELAEREAGADAYWSDRLNAAEEGLA
                     AVERDLARAAETARHTEEDARARGVEALAEARSREERVIRETDRVLRDHEESREELRAR
                     LDHVRGSLAALTGRGTGEEGEGTEVGDGGGAGDTAEEPGVIEVVAVVDAGRQRG"
     gene            complement(17451..18371)
                     /locus_tag="GBW32_RS14410"
                     /old_locus_tag="GBW32_14400"
     CDS             complement(17451..18371)
                     /GO_process="GO:0070726 - cell wall assembly [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003986365.1"
                     /locus_tag="GBW32_RS14410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_14400"
                     /product="LCP family protein"
                     /protein_id="WP_370623012.1"
                     /transl_table=11
                     /translation="MVVVLVAGYGAFVYFWAGGRLRTTEAFSGDGRAKAGKGTDWLLIG
                     SDSRSDLTAEQRRKLHVGGGQGLNTDTLMIVHYGDSGPYLVSIPRDSYVEIPGHGHNKI
                     NAAYALGGAKLLTRTVEQATGLRLDHYAEVDFLGFVDVVDALGGVRICVPKGGLHDKHS
                     GADFAAGCRQMDGVQALAYVRARYTDPQGDLGRVKRQRQLVSAVADKAFSAPVVLNPWK
                     QIPFLRTSLDALTVDKGTGTGTLVGLGREMKKLSDGDGATTTVPIAAEPQISGVGDVVE
                     WDTSKADDLFGALREDTPIPTSGTN"
     gene            complement(18902..22093)
                     /locus_tag="GBW32_RS14415"
                     /old_locus_tag="GBW32_14405"
     CDS             complement(18902..22093)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019986067.1"
                     /locus_tag="GBW32_RS14415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_14405"
                     /product="SUKH-4 family immunity protein"
                     /protein_id="WP_077970281.1"
                     /transl_table=11
                     /translation="MVTFAQAQERAEEWINGELPGYQHRQVLVREFGLGFVVWAEDREG
                     GPVSDGGRQRLVIARDSGEASLWPGLPVGEVIRRYEEEYGAVDAPAARVEQPARIDLNQ
                     TSFLLTPPEWLQEAADKLGIPDQRAGARGEAGGGGFAGAGPGDSGSVGSAPSGSGASGS
                     VPPGAGPPGSVPSGPVPAGASAASGGGTAWPAAEGSAGGAYEPTADDGVPATPWAGTDT
                     NAGSDDLSVQPPATVFAPPLAVPGTRAPGVAPDSGPEAAPVMPDGRRLPPVAMAPEAPE
                     AEQPERLGQPERLGQQSRPDQQGQQGGPGPFPQPGQPVPGTRGRPVPQSHQGQPSPQSH
                     QGGPAHFAQPGQPGQPGQPGQPGQPGRPAAPNPPAPGRPHQPAPADYPDYAAAGGPGDE
                     QRGSGMSPGAGGMSTGAEDIAEAATRKAQPPSKRAERAVPPPPGAPGTPGVRPGGVRPG
                     GGPLPPSAAPDAPGFPGAPGSPGSPGSAGSGYVPTQLVSQLGPEGSPSPGAPSGPSAPT
                     GPSGPGAGTDVGAGAGAGARGPESSGGGVHHAATVFAPPVQGPGPGQGPGPGPGQGPGQ
                     GGRTPSAPQPPAPPGVPGPPGPPGAPGGSQGGTPPGGTPPADAHHAATMLAGPGQVPHP
                     GPPPSGPAPSGPAPSGPAPSGPPAGGPPPPSGPPVAGPPPPSGPPVVGPPPPQGASMGM
                     GAPPMAPPPGTGAGTPPHGPGMPPPPQQGGAVPPGAYGYPQPPAGVPTVGPGYQVVLRY
                     RAQDGSEQQLIRRSAPGTPHPEWQMLHELRAMNVPPQQVLELHTELESCELPGAYCARM
                     IRETWPQARITSIAPYGRDQASRQQGMRELLAHQGELHQVADGPARHAPVRAPLPQVQP
                     APMVPPEAVAQELAGAFGPGVFRFEPGAVSRQGVPEMVASTLVTAGLPYEIGPFFWAQA
                     QPGRPVPTLAELAQERGIQPAADAGSYLVMGSDFGRAVCVQYGTANIVAVPVEAGPGGA
                     PVAPQFVNTGLPEFVRCLALLGRMWRLRFGLNQEQAGRWTVDFQAQLASLDQAALASPE
                     SWWSVLLEQMWDGLL"
     gene            complement(22099..23109)
                     /locus_tag="GBW32_RS14420"
                     /old_locus_tag="GBW32_14410"
     CDS             complement(22099..23109)
                     /GO_process="GO:0042546 - cell wall biogenesis [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003990796.1"
                     /locus_tag="GBW32_RS14420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_14410"
                     /product="SMI1/KNR4 family protein"
                     /protein_id="WP_077970106.1"
                     /transl_table=11
                     /translation="MTTGRLGQGAPPPGSQAGGRAAPPNAAYAGQLVRFPDPVRAARHP
                     GGVRVDGRGFPDFSAYARAAAEIAEPPAGFGVDELRLTDYVSANAAQAAAGHELWDTIA
                     PVATPHGWTWHHVAEGRRLELVPVEVKALLRHHGGLATAAVDQGKRGTRPLQETRPVHF
                     GLPKGSVAVTEQQVAGVEEDLGYRLPGAYRSFLKAAGGCAPVGTALDAELGLLVDQPFF
                     TVRDQADVNDLVYVNKCLRDHVTKDFLGVGFVQGGLLAVKVRGHAVGSVWFCAYDDARD
                     RDGLPVTERVERLLLPCGSDFDVFLERLAGSPPELETVANLMVDGGFARAVPVGV"
     gene            <23837..24316
                     /locus_tag="GBW32_RS14425"
                     /old_locus_tag="GBW32_14415"
                     /pseudo=""
     CDS             <23837..24316
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011028780.1"
                     /locus_tag="GBW32_RS14425"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_14415"
                     /product="YwqJ-related putative deaminase"
                     /pseudo=""
                     /transl_table=11
                     /translation="DPRVDWSSDSSKPPTLRHRRDGILPTVAAALSVRGTTLTCTAGRA
                     DQRPQLHPLVQDFLDTLTSGQRERFTGRCAEALLISRRITAADAARATKSKRAARKPMT
                     AGEARKALKHAKLTTRHIREDGDPLHGGFAPPCRSCTALTAHFGVRVIEPTPHED"
     gene            24336..24839
                     /locus_tag="GBW32_RS14430"
                     /old_locus_tag="GBW32_14420"
     CDS             24336..24839
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018566921.1"
                     /locus_tag="GBW32_RS14430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_14420"
                     /product="SUKH-3 domain-containing protein"
                     /protein_id="WP_077970108.1"
                     /transl_table=11
                     /translation="MHDDDPTHTPSARFPRPVDAVLRTAGWQPGRWDISQAEVWADTLR
                     GHTSPAGHLHTVSPAAVEAWAEFGGLHIVPPGPGREIAPTPFHIDPMHGLHMARTLGDL
                     GLALDTEVCPLGTEPESRTLLAIDSHGRVYGLDHSGDWYLGADIDQGLATLVSGTRPSR
                     LTTT"
ORIGIN
        1 cggacgacgg tgaggtccct ggtcgacagg tccatcccca tcgacgacat gatctccatg
       61 aggccgatgg ccaggcccac gcccgcgccg acaccgagta cggagccgac ggagccgagc
      121 agcagcgcct cgatcagcac ggaacggttg atctgcttgc gggaggaacc gatggcccgc
      181 atcagaccga tctccctggt gcgctgggcg accagcatcg agaaggtgtt gatgatcagg
      241 aagatgccca cgaggaaggc gattccggcg aagccgagca gggcgtacct gacgacgtcc
      301 atgaacgagc cgacgtccgc ctggttctcg gcggcggctt ccttctgcgt ccgcaactcg
      361 tagcggcccg cgccgagcgc ggcgccgacc cgccgcttga gcgccgtgtc actgacaccg
      421 ggtttggcgt ccgcgctgac ctgcgtgaac acaccggtcc tgccgagcag ttcgcgctgt
      481 gcggtcgggg tgtcgaagta gaggacggca gcgcccgggt tggtgacctt gaacgaggcg
      541 atgccggaga tcctggcggt gaagtcaccg gtgacggcga tggtgcgcag ggtgtcgccg
      601 atggcgaggt ggtgcttgtc cgcggtgttg gcgtcgacca tgatctcggt gggaccgcgg
      661 ggcgagtgtc ctgtgtcgat ccgcatcgaa cgcaggtcgt tacgggtcca gttgcccgcg
      721 agggtcgggg cgcccgaggt ggggccgatg ttcttccccc tggagtcgac gacggtcacg
      781 ctcgcactgg tcacgccacc ctcggccctg cgtacaccct cgacctccgc gacctgctgg
      841 acgacggagg cgggcagggt gtcgggcttg ccgcgcgagg tggcgccgtc gccgtcctgg
      901 gtgtccttcg ggttcaccgt gacatcggcg gaggtcgcgg cgaagagctt gtcgaaggtg
      961 gtgttcatcg tgtcggtgaa gaccagcgtg ccgcagacga acgccacgga cagcatgacg
     1021 gccacggcgg agaggaccat gcgccccttg tgggcggcga agttgcgcag ggacatcttg
     1081 agtacggtca tgacgtccgc ccgcgcccgt cgaagtcctt catccggtcg aatacctggt
     1141 cggcggaggg ggagcgcatc tcgtccacga cactgccgtc ggccagatac agcacgcgat
     1201 cggcgtacga ggccgccacc gggtcgtgcg tgaccatcac catcgtctgg cccaagtcgt
     1261 ccacggaggc ccgcaggaag ccgaggatct cggcgccggc ccgggagtcg aggttgccgg
     1321 tgggctcgtc accgaagatg atctccggcc tggcggcaag ggcccgcgcc acggcgacac
     1381 gctgctgctg gccaccggac agctcggtcg gacggtgctt cagcctgccc gcgagcccca
     1441 cggtctccac gacccgctcc agccactcac gagcgggctt gcggcccgct atgtccatcg
     1501 gcagggtgat gttctcgatg gcgttgagcg tcggcagcag gttgtacgac tggaagatga
     1561 acccgacccg gtcgcgccgg agtcgggtga gcttcttgtc cttgaggccg gtgatctcgg
     1621 tgtcggcgag gcggatctcg cccgaggtga cggtgtcgag ccccgcgagg cagtgcatga
     1681 gcgtcgactt gccggagccg gacgggccca tgatcgcggt gaactgcccc gccatgatgt
     1741 ccacgtcgac accgtcgagc gcgacgaccc gcgtctcccc cgctccgtac gccttgacga
     1801 cctgcctggc gcgcgcggcc acggcggcgt gccctccggc caggtcgtgc ctggaattgg
     1861 tcacagccgt tgtcacggta agtctcctat gtcggtcatc accgagccgt cggctctcga
     1921 cgtgcggtgc gttggactgg tgggccgtgc ggtggggcac gcgggtgagg catgcggggc
     1981 ggcacggtgg ggcgggtgcc ggacggacca ccggggtcgg gcccgacacc acccatggcg
     2041 gccaagccgc cctcgtactg tcaactcgcg gtcaggtact ggctctggta ctggctctgg
     2101 tactgagtct ggtgctgagt ctggcctccg ggaggcccgt acgccctggg gcgagacgcg
     2161 gtcttccgcc tgtggaaaac cccacccccc gtgggcgccc cgccccttgc ccagctcacc
     2221 ccagactagg ggcgaacccc ctcgccgctc gtcattcccc ggtaccgacc gaccctggta
     2281 ccgactcggc ctttacccct aggggtactc aaaccacggg tgcacaaggg gagttgctgt
     2341 tccaccctgg cgggaagggg gcgggtggac gagcgtacgg ggcgggcgtg cgagtgccgt
     2401 tccgagcggc atctcgacgt ggtcaccgtc accgtcaccg ccaccgccac cgccaccggc
     2461 tgccgtactg gctcaggctg ccgtgtgggc ccattctgct ccgccgcgtt cgcggtgggt
     2521 gcggcgttcg cggcagtcgc ggcagagggc gtgcgggtcg ctggatcgga aggcgcggtc
     2581 gcagtcgtcg caggtcacca ggggtacgcg gggcagtggg gtgatgcctt cggtggggct
     2641 gaggggttct ggggggagtg ggggtgggcg cagggtggtg aggcggtgtt ccacgaagcg
     2701 ggccgggtgg ttgatggggg tggcgtcgat gggcaggccg gtggtgaggg agcgggtgat
     2761 ctgttccggg gttgccgcgc gggtcagcca ggtttccacg acgggggcga gtcggtgtac
     2821 gtcgtcctcc gacagcaaca gccttgtgtc tgcgacgcgt aggcgggcga ggagatcggc
     2881 cgccgggccc tcgggcgccg gagacaccgg ggccggttcc ggggcggtgc gcttcgtacg
     2941 tacgggagat ggtggcggtg gcggtggcgg cgccggggcc ggtggtggtg cttcagaagg
     3001 cgctggggcg ggggttgtta ccgccgtcct cgtccgcctg gctcgtaccg gcgctcgtac
     3061 cggtgcctgt acggcggcgg caccagccgc accggcagcc gcaccggcac ccgcaccggc
     3121 accggctccc gggtggtcga ggaagaacgt ccgcgtggcg atgcggccgc ccccgagcgg
     3181 cacccggcgg cgggccaggt atccggccgt ctccagttcc cttatagccc tgccgatcgt
     3241 cacctcgccc tcggggaaac gcacactcag cgccttgatc gtgaccgtgg atccgtccgg
     3301 caacgactga atgtgcacgc cgataccgat cgccacagcc gagaggcgag ggtgctgcgc
     3361 caagtgatta ccgacgaccg tgtaccgctc ggtgtggcgg tggcgtacgt ggaggacccc
     3421 ggagcgaggc gcgtcctgcg ggaccgacgg gaccgacggg acctgcggag ctggaagctt
     3481 cggaggaacg ggcaacgact gtgccggcaa agggggcaag ccactcgggc gcgcgggcac
     3541 gtcagcacta gacttcggtc cagccatggg gaagctcttt tcttcctgcg tggtcagacc
     3601 ctcgtcagga ttgccgtcct gtcgggggtc gttcactgtc tgtggttgtg gtggtgtgcg
     3661 gcgaccgtac cccaccaaac cgacccgcct atgcccccgc cacccgaacg agtggctacc
     3721 aattgccggg cggtcaggcg gggtttggtt tggttgttaa tttctccaag tgctttaaag
     3781 ggcagcggga acagccggat cacgggctcc cgcgtcccgg cgctgacctg ggcggatacc
     3841 gactacgaac gccacggacc ccatggaccc cacagtcgat accctggcct ccgcgcaggc
     3901 ccataggccc atggtccata ggtccatagg ccccgtcagg agaggacgta gtccgccgcg
     3961 ctcgtcacca gcgtcgcgaa gttctcgtac cgctcggggt cgccgccctc tcccggccac
     4021 cactcgtacg cggtccactc gccgtcctcc cgcgcgctgt cggcgtgcag cacccagtag
     4081 ccgccactgc cgccgtcgtc gatcgagatc aacagggacc gctcgaactt gtcgagatcc
     4141 tcggcgaggt atccgtcgcc cggcgacaac caatagtcga ggagatcggt catatcggaa
     4201 aaccacccga tcttctcgat accgagcaga tcgatgaggc cgacgtcttt acagccgttg
     4261 ctggcgagca ggaagttgcg gtacgtcggt ggcagtcgga caccgaaacg ctcctcggcg
     4321 gccaacaccg cagcctcggc cgcaggctcg tagccgagcc agcgggcctc tcgttgggcc
     4381 tcactcagaa acgacctccc ctccgcgtcg gcctcgcgaa aaaggtccga cgcgaggaac
     4441 ttggcgctgt agtcactgag gaattgacgc cattcgggga cggtcaacgg ggagggtgcc
     4501 acgtctgagt tccttcggta gtgcgaggtc gcgtacgcgt cggcatcctc gcacgaaggt
     4561 ccacggcttg atttccgggt gggccacgag caatgcccgg cccctgccgg gctggctgga
     4621 agccgatccc gcggactgta cgggttccgc gccgtccgcg aggatggcag gcgggttcgg
     4681 gtgtctggtc gtgcgggcgc cgcgagatct tccggtcgtc gggaagccgc gctcgtacgt
     4741 tccgtcggtg atggcacggg aggactcgga tgagtccgca cgtatcaact gccggggcgg
     4801 gcggacgagt ggacttcgaa ggaccgggcg gaagtcgccg ccgatagcgg aagtcgccgc
     4861 cgatatcggt ggccactgtc ggcgcgaggg gtatctcttc gttcacaacc acggcgttcg
     4921 tcgtccagcc gctggacgcc ctcaccggac cggccgaccc gcccgcctac gcgcccctca
     4981 acaccggccc cgactacgtg gccgtgctgc gatccctcct cgcgggctga cctcccggcg
     5041 gacatcgcat cccggtgtcc cggctgccgc cgacaggtca gccgcgcccg cgggggcgat
     5101 cgctggccca ctctccacct gttcgcggga gggggcggcg gcgacacgac ctggaccagc
     5161 ctgttcaagg agcaggacct gcctgagtac cgtctaccgg ctcaaaacgg ttcgcccgtg
     5221 tcgagccggt gcgaacagcc ccttgcccaa caggatttca cgcgtgtgag cacgggtgcg
     5281 cggactcagt ccaggtaggt gtcgtactgc tcgacgtcac cgggcttgag ctgcatctcc
     5341 gggtcggtct tgatgctgga gagttccgtg cccaggatgc gtcccgtgtg ctcgtcgagg
     5401 atgatcgtcc accgcaccgt ccccttgaag tccactccgt acgcctggcc ttggcgtccc
     5461 gcacggtcct tgacagggcc gagggcgttc agacccgact gctcggcgag caggccgtcg
     5521 atcgcggctg tctgggcggg ccctggcgtc cactcacgca gcagcgcctc cacggtgtcc
     5581 atcgtccagt acgcgctgcc gtggatgtcg gggttgtcct tcgccaggta gtcggcgaga
     5641 ccacggacgg tggtcggggg cgtactccgg aaggaggcga gcttctccca cgacccggcc
     5701 ggcttgtgcg tgcggtgtgt gacccggccg tccttcaggt cctccaccac accgctgccg
     5761 tcggcgttcc agcggtcgcg ggactcgtcc accggcatct cctccggctt gtgcttgccg
     5821 tcgtcccaga gccccagcgc ccactccata cggtgggtcc ccctgcgcgc gtcgccggga
     5881 gagtcggcca gggcggcggc ccgcttcgcg acggtggcga gcggcacggt ggcccgggag
     5941 ctctccacct tgagcggggc gggcgcggcg acggccgtct ggccgctgct gccggtgagg
     6001 gcgaaccccg ccacggtcgc cgcgacgacg gcggcagccg ccccgaggga catcgaccgg
     6061 ccgggcgtca gccagccgaa ggccggggaa cggcccacgg aggagcggga cttggaagat
     6121 ttcacggact tcgccggccc ctcgggcgtc gcggacttcg cgaaccccac ggacttggcg
     6181 gacttggcgg ggtcggacgc gacggccgtg tcgttgatct cgttcatcag gtgcgcccga
     6241 agctccgcgt gccgggtggg cgagagccgg gcggcgggcg gcggaaccaa cgcacgcagc
     6301 gcggcccgct cggagcggtc acgggcctcc tgccactccc cgtccccctc ctcgtgggcc
     6361 gggtcagaag gacgggagga cggggacggt gtggtggcgc cgacacggtt ccggaacagg
     6421 gcgttcatgc gaggttctcc tgggtggttc gagccggaat gctgtctaca cgctgtatct
     6481 gtccgctgtc tccggggagt tcccgaccgg aggcgccctg tgtgtcgtcg tcgcgccggg
     6541 cggccgggtg ccgcacggag tcacgcatcc gaccggaggc gccctgtgtg tcgtcctcgc
     6601 gccgggcggc cgggtgccgc acggagtcac gcagcttggc gcgggctcgg gacagccggg
     6661 accgcacggt gccgacgggt atgcccaggg cctcggcggc ggacgcgtag tccagctcgc
     6721 cccagacgca cagggtgaac acctcgcgct cggtacgccg cagccccttc agcgccgcct
     6781 tggccgccgc cagctgttcg gcgtcggcca gccgcccggt cacctcgtcg gcgaagtccg
     6841 ggacggtgtc ccctcgtggc atccgggcca gggctctctg gtgccgccgg gccgaccggg
     6901 ccgtgttgcg cagcacgttg gtggcgatgc cgagcagcca cgggcgcaga ctgccggtct
     6961 cctccgggcg cagccgctcg cgcgagcgcc acgcctccag gtaggtgagg gagacgacat
     7021 cctcggccgt ggcccagttt cccgtggacc acagggcatg gcggtacaca gcgtccgcgt
     7081 gctcctggaa cgcctcggcg agcgcggccg ggtcaccttc gcggagacgg gcgtgggttg
     7141 agtgagtcac gtgaagtact gtccgaacgg tctgacgggt tcctgtgacg tgtgtcaccg
     7201 ggcgtgccac cgggcttggt cttcgggtcg acttccggtc gcgttcggcg tccaggagca
     7261 gatttctgag gtgcggcttg gcggcgaacc cgccgtgtgg ccccgccagc ccgagatcag
     7321 ggacgcggtg aacccgccac ctgcgggtcg acctgctgcc ttggcaccct tcggtcggaa
     7381 cagttccagc accacccacg gcccgcccgt ccgtgagatc cccaggcgca atgaaccggg
     7441 atcattcaca gcctcaacgt ccactttcca tgcacgcttc caatgcggcg acacgccaaa
     7501 ggcccgccct ccggcctgaa cgggagacgg gccttctcag cagcagcgag tcgggatcac
     7561 agagagtcag gcaggaggct ctcctgaccg gcacggacac ccttgcaata agcgacgtac
     7621 tcgctctcgg tgagcgggat gaggtggtcc gtcaggatgg agtggcggag caggtacccc
     7681 ttcccctgga ccttcgccac ctcaaggcaa tcgcctgaac cgccggcaga tgcctcggac
     7741 ttgatgaatg cgagcgtgga ctggtcgaca tccagcatct cgttgagcag agccttcttg
     7801 gccttgaggg cttcgtcagt cactcgaaat ctctcttctg attttcccga tacgttccaa
     7861 ggactcttcc ggagacagag aaagatcttt caagtctccg acgaagtgct tcaacccacg
     7921 gatctccttg ggtgtctctc tgaaggccat gcctgtcatg acgtcgaacg cggcgaccgg
     7981 cctctccgcc tccccgaact ccagcaggtg gaaggggtaa gccagtgcgg cgttggcctc
     8041 gtagggaatg acgcggaaga ccacgccacg cgtcgtcgcg tcatccatca gtgagtcgag
     8101 ctggcgaccc ataacttggg gcccgcccac ctgctggtgc aaggcgccct cgccgatgat
     8161 ggcctcgatg accggtggac tcgggcggtc gaacacctta cgacgtttct gccggaaggc
     8221 caccgatcgc tccacggcct gctgcgtcat cgtggattta cccaggtagc tcgttagggt
     8281 gcgcccgtag tccgggatct ggaagagccc ggggacgatg ctgccggcac aggtgacgat
     8341 cttgttggcg atctgctcgt tggtgacgaa ctggagcagg ctggggtccg tgtcgtcagc
     8401 gaactcgatc caccaggcgc tctcaacgat ggccagaccc tcggaccgca tggtctccag
     8461 ccggacgcgc gtgacgtcat ccatctggag gaagtcgcag atcgtggccc attccttgtc
     8521 cttgggccag gtttctcctc gctcgatacg ggagtaccgg tgatacgtct tctggccgag
     8581 cgcacgggcc acgtggatct gcttcaccgg gccatcaccg cgcggggcag caagacggac
     8641 ccgctgaagc gcggctccga agcgctcccg cgccgaattc gcgacaggat tgagcgccat
     8701 gatcctcctc ccctctccag cgattcttca gccagagcgt agcgcgtgac cccttacgga
     8761 cggcacttcc gggggtaatt ccagcatcag ggttgcgtac gcagttgcgt acgcaccaca
     8821 ctcgtcatca cgcaccgggc gacctacgtc gcggtgtgtg acgagttgcg cggccggcca
     8881 cagtcgcgca ctggaggtca ccatgtgcac gaccgggcat cccgcgagcc cgacctcagc
     8941 ggcgagatgt ttcgcccgcg atcccaactc ggtaccgata gcgcgtagtt gggctacagc
     9001 agtatgcgag agctacggcg tgaccgacga tctgttagag acctgcaagc tcctcgtcag
     9061 tgaggctgcc accaacgccg tcacccacgg cgggggcgac gagttcacgg tagcgatctg
     9121 ccgggacctg tggatcgaag tctgagccgc agcaccggaa ttgcccaccc agcgcgagca
     9181 cgcactggat gcggaggggg gccggggcct ccagttgctg gaccttctgg ctccgggcta
     9241 tcaggtcatc caggactcga ctcgcggcgg gaagtgcgtg cgctttctgc cgaaggggtg
     9301 ggcatgagcg catgcatggc ggggaggccg gacgacaccg tggcatgcgc cctcttggtg
     9361 atcctcagca ccgcgatatt gaccggcctc tcctccatga tgctcgcggg agcccggcac
     9421 tcggagcggc accgctgcca agccaagatc gatgaggaac gcgtcggcta ccacgacttt
     9481 ccggacgaat acccactcaa ccccaatacc ggcccgagat gacagcgtca aaggtggaac
     9541 cgccgtcacc gagcactgaa gcgccggggc ctgcggtaga ccactgagtc attgccgatc
     9601 cccggggacc agcaccgtcc ttccactgcc ccaaggaggc acgcatgacc gtacaactgg
     9661 aacagccagt cgctcccgag cagccgacag ccaccgacac cgacaccgac gaggccaccg
     9721 acccgttcca actcgacatc accttcatcg agaacactcc ggcgaccgag acgatgctga
     9781 tgtgcagcac cggcgacaac tgcggtagct cctgcccgag cgcctgcacc acctcgtaac
     9841 gaggtctggc ccgaggcgcg ggctgggcgg acaccccgtc ccgtccgcgc ccttccctcg
     9901 aagaaacgga gtctgggtga tgacacgctc acggcacagt ctgtacaggg gcgccgataa
     9961 agggatgctg cgcgctgcgg cgaacctcgc tgagccggag atgccccctt ggccgaagcc
    10021 cacggctccg ctcgaacact ggcgatcgtg gctggcggca gtgtgggccg atgacacctt
    10081 ccgacaggcc gtgtccagtg caagccccga cctgtcccgc cagacccagt cgatcatcga
    10141 tggacgctca cccaaaatgc gccgggtacg acgggcggca ctggccatcg ctcggtactc
    10201 gatcaggtac gcgcaccgtt ccactccgta cggcctgttc gcgggcgtcg cgctgaccga
    10261 gttcggcgag acggccgagg tgcgcttcgg ggaccgaaat cgagctgtta cccggccgga
    10321 cccggcggca ctggacgcgg cgatcagcgc ctgggaggcg gacgccgagg gggtggcgga
    10381 cctggactta tgcgtcaaca acctcgctca gcagcgaagc ggacgcatct atgtaccgtc
    10441 agagggggcg tcggagttct ccctcgcgct gacccccgcg gtcgtgctcg tactcaccgc
    10501 ggcgcggttg ccgatccggt attcggctct ggcggacaag ctcgccgccg agttccccac
    10561 cacgaccgaa caccaccggg cccggatgct cgcgcagctc ttggaagtgc ggctgctgct
    10621 gtcctcgcta cgcgctcccg ccactgtcgt cgatccggcc ggacccgtac cacctgtcct
    10681 gcgggagaac ctccggaaca atcaggcggc accggatctg cgactggacg ccacagttcg
    10741 actgcccgag gtggtcatga gggaggcgga gaccgctgcg acggtcctca cccggctcgc
    10801 cacccatcca aagggtatcc cggcctggcg ccgctacgcc gaacggttcg ccgaccgttg
    10861 gggcgagggc gtcgaggtgc cgttggaatt ggtgacggac cctgagaggg gtttgggctt
    10921 ccccgagggg ttcggccagg tttccgagcc tccccgcccc atgatccaac gagaccggct
    10981 gctcctggag ttggccggca ccgcaggcat cgagggcaac agatccgtgg tcctgtccag
    11041 cgctatggtg gagcagttgg aggccaccgt cggcaagcca gtgaacacac cgcctcacct
    11101 cgaattgggc gtgcaggttc aggccgactc gacacacgct ctgaatcacg gcgactttcg
    11161 ccttcgggtg tccaccgtct cccgttcggc cggctcgatg acggggcggt tctggcactt
    11221 gttcccgaac gtcggcgcga catatgccga cctgcccaca gtcgaacccg acgcggagct
    11281 ggcccaattg tccttccgtg cgggccgcgt ctccgctgac ctgcttacac gtgccccaca
    11341 agcgctgccc cgggtggtca gcgtcgggga gttccggcat cgcacggagg gggtactgtt
    11401 cccgctcgac ctggcggtgg gcatccgcga gggccgcctc tacctcgcag agatcgctac
    11461 cggcacgcac ctggagctgc tcgcccctac cgcgctcaac ctcctgtgga acaactacac
    11521 ccctcctctg gctcggtacc tggccgagat cagtcgtgcc ggagcgtcgc aggtaacttg
    11581 gttcgattgg ggcgcggcct ggacccttcc gttcacgccg gcgctgcgct accggcgttc
    11641 gatcctggtg tccgcgcgat ggaaagtgcg gtctcgggat ctgcccggcc gcactgcgac
    11701 gcgggatgag tgggccgggc ggttgcatgc ctggatggaa cggttccgtg tatcggaccg
    11761 cgtgctcctg gccgaggacg accaacgact tcccctcgat ctgcgcctgg acatgcacct
    11821 cgacctgctg cgcacccacc ttgacgccag ccccatcggt gtcgcgacgt tgtacgacgc
    11881 gccgccccca aacgctgacg gctggatcgg cgggcgtgcc cacaacttcg tactgccact
    11941 gatggcatgt ccatgaaagg gatgacggcc cggcctggga cacaagacct ttccgagggc
    12001 actcttggag tggctctact acacatcgag cgcggggact tggctgccgc gcgcagctgc
    12061 ctggaagagg cggtcgcagg cggtgtcagc gccggaggca acgcgtcctt gttccacggc
    12121 gccccggccc ttgaattcgc actcagccgc gccggacacg ccggacgtga tatccacgac
    12181 accgtcgacc ggatcgttga cgctcggctg gccgcagcga atcgacggcg ggaaaccggg
    12241 gctctgccgc atctcggaga gttcgacctc attcggggtt tgagtgggct gggagcgctg
    12301 ctgctgaccc gaggcgcggc ttcgccgctg cttgaggagg tgctggctta cctggtctcc
    12361 ctggcgcggc cggtccgtat cgagggtcgg gagctgccgg gatggtggtc ggaggcaggg
    12421 cccaacggtg ctgagatgga cggcggacac ggcaacaacg gtctcgcaca cggcatcgcc
    12481 ggtcccctgg cgatgctgtc cctcgccttc caacatgacg tccaagtacc ggggcagcgc
    12541 gaagcgatcg agaagttcgc gcgctggctc gacttgcacg gcggtcacta ctggaccacc
    12601 cgtgcccact tggacgcctt cgaaccaccc gagccggagc cagcccgtca gtcctggtgc
    12661 tacggcgggc cgggtatcgc ccgtgcccaa cagctcgccg cgctcgcgct ggacgatccg
    12721 gaccgacgca aggcggcaga ggacaccgtc gtgcacacgc tgacccatcc tttccacctc
    12781 gcccggatca ccgacgccac gctctgccat ggctgggccg gcctgctgac cctggcccgc
    12841 gctgtcgccg ccgacagccc cgctccggag cgcttcagct ctctgatcgg cgacctgcac
    12901 cgccatttgg cctcagacct ggaccagcta ccgaagcccg gcttcatgga gggccgtagc
    12961 ggagcgcagc tcgccctcga cggcacgaat gccacggact ggaccagcgt gctgttgatc
    13021 acttgaccac ccgatcccac cgagatggag cgcccacaca tatggccttc gacgatgacg
    13081 agaaccttcc gatcacccac gacacgagct ggtggcatgc cagcgtgact ttccccgggg
    13141 atgtggtgag ctccgaggct gccaagttcc tggcggccgc cctgcacgac cagcgcttcc
    13201 acttcctgcg caaggactcg gggctgcgtc tgcgcactga acgcccctcc gacgacctgt
    13261 gcgaccgcct tatcgctcag cagctggcca ccgggtgggt cggcggcatc tacgaaccgg
    13321 aattcgatgc attcggtggg cccgagggca tggacgtggc acacgaggtg ttctgcgccg
    13381 acagccgcag cgccctgttt gagaccggcg caccaggcgc ccgagagcgc tgcgtgatgc
    13441 tgctgtccgc catgatccgc gaagccggtc tggatccctt cgaggccgga gacgtctggt
    13501 cgaagctggc cgccctgcgg ccccacgtca ccccacccat cgggcgcaga ctcgaccgct
    13561 cggtctcagc catgtggcgc ctgatgaacg cggacgcgac ccgccggccg gatgcggaac
    13621 ccggctggac ggagcgcgtc gccactttcg agaaggccgg ccgccgcctg cgccggctca
    13681 ccgccgatgg gcgactcata cgtggcctgc gggctgtcct cgcccatcac gcgatcttcg
    13741 cgttcaaccg cgccggcgtg cctgccatcg agcaggccgc caccgcctgg cttgcccgac
    13801 aagtcgcctt tgccgcatgg gaagagaccg atgtgtcttc ccgccgaacc acttccatgg
    13861 acctcggcct cgcccgattg gagaccaccg tgacacctgt caccgaccct gccgaactac
    13921 gcgaaatctt ggtggaccgc ctcatcgaca gcggccgtct acggtcccct gccgtcatcg
    13981 acgccttccg caccaccgac cgccaccagt tcctgcccgg cgtcgacacc gagacggcgt
    14041 acaaggagga cgcggtcccc atcaagcacg acgaaaacgg cgagatgatc tcctgtatct
    14101 ccgcgccctc catcgtcgcc acccagctcg aacagctcgg tgcacggccc ggcgagaaaa
    14161 tcctggaggg cggagccgcc accggctata acgcctgcct agtgggcaaa gtcgtcggcc
    14221 cccacgggca cgtgtggacc ctcgacatcg accaggacct cgtcgccgga gccgaaacca
    14281 acctcgccca acacgggact accaatgtga ccgtcgtgct ggccgacggc gctgtcggcc
    14341 ttcccgagca cgccccgtac gaccgcatcc agttcaccgt cggcgcgggc gatgtcccgg
    14401 tgaaactcct cgaccagctt gcccccaatg gccggctcgt cctcccgatg cggattcgcg
    14461 gcagcgtcag ccgcagcttc gccttcgagc gcgacggcga cacctggaag actgtctcgt
    14521 gcgagatggc gacattcgtg ccactgcgca agggcgtctg cgacgacatc tacaccctcg
    14581 tgcccatgga cggtgagggc aacgtccgcc tggaaacctt cagcgagcag gaggtcgacc
    14641 gcgacgcgat ccgcactgtc ctggatcaga agcaggccaa gatttacacc ggggtgaaat
    14701 tccgccaggg cgacccctgg gagtggctgt acctgtacct cgcgtcggtg ttgcccaacg
    14761 gcctgtctcg catgcccggc cagcgttccg gcttcacccc gcacttcggt tggggctcca
    14821 tggccgcgct cgacggcgac agcctggcct acttgaccat ccgcgaaagc gaggacgtgg
    14881 agggtaggtt ctgggagatc ggcgtcgttg gccacggccc ccgcgccgcc gaactcgctg
    14941 accaagtcgt gacggagatc cgctactggg acaaaggatg gggcaatacc gcgccggaac
    15001 ccatcttcca tatggctgtc ggcgacgccc gcgacaagct gacagcctcc gagccgcgct
    15061 tcgtcatcga caagacgtac agccgtctcg tcgtggactg gccgcgcaag ggctgagcag
    15121 atgaatctct cgatggccag ccgcatcccg ctggtccgcc gtcacaaggc gccggcgtta
    15181 ccgctggacc aacgcattac ccacctcacc gggctggctg tcgagctctc cggtgcgagc
    15241 catcacgatc tcgtggctcg cgccagcggg gtcctcaatt acgccgctct ggtcgcctcc
    15301 gatgtcggga tacctgacct ggcagccgac ctgtgttgga ggcagcacca ggtattcgcc
    15361 ggtgctggaa ccctcacgga ggacatcgcc gtgatgtcac tcatgcccct gatcaacatc
    15421 tctcggctgc tgacccgcga aggtgacggc gaagccgcct acgacgtact cacgcgcttg
    15481 tatcgcgcag ccctgaagcg cggccctgtc gagattcgtg ggaacaccgt cgatctttcg
    15541 gtgctgaccg ccacggatgc ggaccatcgg aaggtctgcc aggaactgtg ggtaaccgta
    15601 ctcgtcgacg gcgccagggc actcgcgcgg atcgggcgct ggaccggtgc cgccgaagct
    15661 atgacagcac atcgtggcat cggcaatcgt ctcctggacg gacgccaaat catgattatg
    15721 tcgctgctgg aacgcggcct ctaccagcag gcacgcgaca cgatcgagtc cagcgtcttg
    15781 accgaaccgt gggaaaacac cgttgcggcc cttcttcacg tctgctgtcg gcccccgggc
    15841 tcgcgcacac cgcagtccga gctggaccat gctctgcaag aggcaacagc actgctcgcc
    15901 ccgcccgacg cttcgaccgt ggtgttccag gcccgcgtgg gattgaccgc gcttgagctg
    15961 gtccccgacc acaccgcccg cccggtcgtc cctctgcggg aggccatcgc caatatggcc
    16021 agtcgcgacg catacgctgc ccgcgaagtg ctgaaccacc ccgtgctgtc cccccgcctg
    16081 gcctgtgagc agagaaaggc actcactgcc gtgatcagcg cttcaggact cggcgcgggg
    16141 gaacttccgc aggcccatat gaacgccctc actgagtccg tggaaaaagc cgaagccgcg
    16201 ctgggcagac tcctgtacac atagatcgtc cggcgggcaa caccggggcc gggcgcacgg
    16261 gatcgcatcc cggtcccatc cgtctacctc gccggggcac cgagcaccgg tcccccgctc
    16321 aacccctttg ccgccccgcg tcaaccaccg caaccacctc gatcaccccg ggctcctcgg
    16381 ccgtatcacc cgcaccaccc ccgtcaccca cctcggtccc ctccccctcc tcccccgtcc
    16441 cacgccccgt gagcgccgcc aaactgccgc gtacgtggtc caagcgggcg cgtagttctt
    16501 cgcgggactc ctcgtggtcg cgcagtacgc ggtccgtctc gcggatcacg cgttcctcgc
    16561 gcgaccgcgc ctccgcgagc gcctccacgc ccctcgcccg cgcgtcctcc tcggtgtggc
    16621 gcgccgtctc cgccgcccgt gccaggtcgc gttcgacggc ggcgagtccc tcctccgccg
    16681 cgttcaaccg gtccgaccag tacgcgtcgg ctcccgcctc acgctccgcg agttccccct
    16741 ccgccgcctc ccagcggtcc gcctgctcct tctcctgggc cgcgagcagc gcctcgcacc
    16801 gctgcctggt gtcacggagc accgcgaggg attcgccgcg ccactccttg acatcgcgcc
    16861 tggccgcttt cctgatctcg tcggccgccg cacgggccgc cgcgtcccgc tcgtccgccc
    16921 acccgcccgc ctccgcgagg accgccccgg cgtgggcgcg cgcccgctcc cccgtatcgg
    16981 cggcgtcccg ccctgccgcg tcgaccaccg acgcccccgc cacccgcgcc gcttcccaga
    17041 gggccgccgc ctcctcctca ccgagggcga gtatccgcac cgcgcgctca ccgagggcct
    17101 cgtacgtctg gggcgcgagc ttcgcgacga cgtcccgcag ccggtccgcc tcgccccgca
    17161 tctccttggc cagtacggtc agccgcgccg cgcgctccca cgccgcgtcg cgggaaccgg
    17221 acagctccga cacgtacggg tcgacctgac cggggcggta gccacggctc cgtacggacg
    17281 gaggtacggg agcgaagccg tgaggcgatg ccgacacact gctcatcctt gaatcccctc
    17341 tacgactacg actacgaccc cgtgggctac gcgaccggcg cacatcctga tggatcaagc
    17401 cgaactgccc ataccgcgac actccaccca tctccgtccc caaggatgcg tcaattggtg
    17461 ccggaagtcg gaatcggggt gtcctcgcgc agcgccccga agaggtcgtc ggccttcgac
    17521 gtgtcccact cgacaacatc tccgacaccg ctgatctgcg gttccgccgc gatcgggaca
    17581 gtcgtggtcg caccgtcgcc gtcagaaagt ttcttcatct cacggccgag accgacgagc
    17641 gtccccgtgc cggtgccctt gtcgacggtg agcgcgtcca gcgaggtacg cagaaacggg
    17701 atctgcttcc aggggttcag caccaccggc gcggagaacg ccttgtccgc gacggcgctc
    17761 accaactggc gctgccgttt gacccgtccg agatcgccct gcgggtccgt atatctggcc
    17821 cgtacgtacg cgagggcctg gacaccgtcc atctgccggc agcccgccgc gaaatccgcc
    17881 ccggagtgct tgtcgtgcag cccgcccttg gggacgcaga tccggacacc accgagggcg
    17941 tccaccacgt cgacgaagcc gaggaaatcg acctcggcgt agtggtcgag ccgtagcccc
    18001 gtggcctgct ccacggtcct ggtcagcagt ttcgcgccac cgagcgcata ggcggcgttg
    18061 atcttgttgt ggccgtggcc cgggatctcc acatagctgt cgcgcgggat cgacaccagg
    18121 taaggacccg agtcgccgta gtgcacgatc atcagcgtgt cggtgttcag cccctggcca
    18181 ccgccgacgt gcagctttcg ccgctgctcc gcggtgagat cggagcggct gtcggaaccg
    18241 atcaacagcc agtcggtacc cttccccgcc ttcgccctgc cgtcgccgct gaacgcctcc
    18301 gtggtgcgca gccgtcctcc ggcccagaag tagacgaagg ctccgtagcc ggcgaccagc
    18361 accaccacga tcaggaccgc cagggccagc caccggagcc aacgtcgctt tccgcctcgg
    18421 cgcccgcgcg gtcggcgggg gctcggctcc gcgcccggac cctcacccgg ccactcggga
    18481 ccaccggaac ccgagccggg gccgcccgaa cccgatccgg gaccgccgga acccgagccg
    18541 ggaccgccgg aacccgagcc gggaccgccg gagccgggac cactcggccc ggaacctgac
    18601 cctgacccgg acccgccagg gccccatccc tgcggcggac ccgagaaggc attcgtacga
    18661 ggcgtaccca tggctgcatg atcggtgcgg ccaggcccag gacaggagcg ccccacccgt
    18721 cccccgggcc gcgcgccccg tacggcctac gctcccgagc caccggaccc gcgaaggacg
    18781 cgcaaccgga cgtgccaccg gacgcgccac cggacgtgcc accggacgtg ccaccggacg
    18841 tgccactccg gcagagaacg ggaacggatc gagaacggga actgaacggg cacgggaccc
    18901 cttaaagcag gccgtcccac atctgttcca gcagcaccga ccaccagctc tccggcgagg
    18961 ccagcgccgc ctggtcgagc gaggcgagct gcgcctggaa gtccacggtc cacctgcccg
    19021 cctgctcctg gttcagcccg aaccgcagcc gccacatccg ccccagcagc gccagacacc
    19081 gtacgaactc gggcagcccc gtgttcacga actgcggcgc caccggcgca ccaccaggac
    19141 cggcctccac cggaaccgcc actatgttcg ccgtgccgta ctgcacacag acagcccggc
    19201 cgaagtcgct gcccatcacg agatacgagc ccgcgtcggc agccggctgt atcccgcgct
    19261 cctgtgccaa ctcggcgagc gtcggcaccg gacgccccgg ctgggcctgc gcccagaaga
    19321 acggcccgat ctcgtacgga agccccgcgg tgaccaacgt gctcgccacc atctccggca
    19381 caccctgcct ggacaccgcc ccaggctcga accggaacac accgggcccg aaagcccccg
    19441 ccagctcctg cgcgaccgcc tcaggaggaa ccatcggcgc gggctggacc tgcggcaacg
    19501 gcgcccgcac cggggcgtgc cgcgcgggac cgtccgccac ctggtgcaac tccccctgat
    19561 gggcgagcaa ctcccgcatg ccctgctggc ggctggcctg atccctgccg tacggcgcga
    19621 tcgacgtgat ccgcgcctgc ggccaggtct ccctgatcat ccgcgcgcag tacgcccccg
    19681 gcagctcgca cgactcaagc tccgtgtgca gttcgagcac ctgctgcgga ggcacgttca
    19741 tcgcccgcaa ctcgtgcagc atctgccact ccggatgcgg ggtacccggc gcggaacgcc
    19801 gaatgagctg ctgctcggaa ccgtcctgcg cccggtagcg cagcaccacc tgatagccgg
    19861 gccccaccgt cggcaccccc gcgggcggct gcggataccc gtacgcgcca ggaggcaccg
    19921 caccaccctg ctgcggcggg ggcggcatcc ccggcccgtg cggcggcgta cccgcacccg
    19981 taccgggagg cggagccatc ggcggcgcgc ccatccccat gctcgcgccc tgcgggggcg
    20041 gcggccccac gaccggcgga cccgagggcg gcggcggacc tgcgaccgga ggcccggacg
    20101 gcggcggagg cccaccggca ggaggacctg acggcgcagg acctgacggc gcaggacccg
    20161 acggcgcagg acccgacggc gggggcccgg gatgcgggac ctgaccggga ccggccagca
    20221 tcgtcgccgc gtggtgcgcg tcagccgggg gcgtaccgcc gggaggtgta cccccctgag
    20281 acccgcccgg cgctcccggc ggacccggcg gacccggcac gcccggcgga gccggaggct
    20341 gcggcgcgga gggagtacgg ccaccctggc cagggccctg acccggcccc ggccccggcc
    20401 cctgacccgg ccccggcccc tggacgggcg gggcgaacac cgtggccgcg tgatgaaccc
    20461 cgccacccga cgactccggc ccacgcgcac cggcaccggc accggcaccc acatcggtcc
    20521 ccgcacccgg ccccgaggga ccggtcggag cggagggccc ggagggcgcg ccaggagacg
    20581 gcgacccctc aggcccgagc tgggagacca actgcgtcgg gacgtacccg gagcccgcag
    20641 aacccggcga gccgggcgaa cccggcgccc ccggaaagcc cggagcgtcg ggcgcggcgg
    20701 acggcggcaa cggaccacca cctgggcgta caccacctgg gcgcacaccc ggagtaccgg
    20761 gcgcccccgg cggcggaggc accgcacgct ccgcccgctt cgacggcggc tgcgccttac
    20821 gggtcgcggc ctccgcgatg tcctcagcac ccgtcgacat cccgccagca cccggcgaca
    20881 tcccgctccc gcgctgctca tcgccggggc cgccggcagc cgcgtaatcg gggtagtcgg
    20941 cgggggcggg ctggtggggc cggcccgggg cgggcggatt cggcgctgcg ggccgacccg
    21001 gctgccccgg ctgccccggc tgccccggct gccccggctg ccccggctga gcgaagtggg
    21061 cgggcccgcc ttgatggctc tgcggggacg gctgaccctg atgactctgc gggacaggcc
    21121 ggcctcgcgt cccgggaaca ggctgtccgg gctgagggaa cgggcccggc ccgccctgct
    21181 gtccctgctg gtccggtcgg ctctgctgcc ccagccgctc cggctgcccc agccgctccg
    21241 gctgctccgc ctccggcgcc tccggagcca tcgccaccgg aggaagcctg cgtccgtccg
    21301 gcatcaccgg agccgcctca ggacccgaat ccggcgccac ccctggcgcc ctcgtacccg
    21361 gcacggccag cggcggggcg aacaccgtcg cgggcggctg caccgacaaa tcgtccgagc
    21421 ccgcgttcgt gtcggtcccc gcccaaggcg tggccggcac accgtcgtcc gcggtcggct
    21481 cgtacgcgcc cccagcggac ccttcggcgg cgggccaggc cgtaccacca cccgaggccg
    21541 ccgacgcgcc cgccgggaca ggccccgacg gcacggaccc cggcggcccg gcacccggcg
    21601 gcacagaccc ggacgccccg gaccccgacg gcgcggaacc gacggaaccc gagtcaccgg
    21661 gacccgcacc cgcgaaacca ccaccacccg cctcaccacg cgcacccgcc cgctgatccg
    21721 gaatgcccag cttgtccgcg gcctcctgca accactcagg aggagtcagc aggaaagacg
    21781 tctgattcag atcgatacga gcgggctgct ccacccgcgc ggcgggcgcg tcgacagccc
    21841 cgtactcctc ctcgtaccgc cggatcacct cacccacggg caaccccggc cacagtgagg
    21901 cctcaccact gtccctggcg atcaccagcc gctgcctgcc gccgtccgag acaggaccac
    21961 cctcgcggtc ctcggcccac accacgaacc ccagtccgaa ctcccgcacc agcacctgcc
    22021 ggtgctgata gccgggcaac tcgccgttga tccactcctc ggcgcgctcc tgcgcctgcg
    22081 cgaacgtcac catcccgctc acacccccac cgggacggca cgcgcgaagc caccgtccac
    22141 catcagattc gccacggtct ccaactcggg cggactgccc gccagccgtt cgaggaagac
    22201 gtcgaaatcg gaaccgcacg gcaacagcag ccgctccacc cgctccgtca ccggcagccc
    22261 gtccctgtcc cgcgcgtcgt cgtacgcgca gaaccacacc gagcccaccg cgtgaccacg
    22321 gaccttcaca gccagcagac cgccctggac gaaaccgacc ccgaggaagt ccttggtcac
    22381 atggtcccgc agacacttgt tgacgtacac caggtcattg acgtccgcct gatcccgcac
    22441 cgtgaagaac ggctggtcca ccagcagccc cagctccgcg tcgagcgcgg tacccacggg
    22501 cgcacagcca cccgccgcct tcaggaacga cctgtaggca ccgggaagcc ggtagcccag
    22561 atcctcctcc acgcccgcga cctgctgctc agtgaccgcg accgaaccct tcggcagccc
    22621 gaaatgcacc ggacgcgtct cctgcaacgg ccgcgtacca cgctttccct ggtccaccgc
    22681 tgccgtcgcc agaccaccgt gatggcgcag caacgccttc acctcgaccg gcaccaactc
    22741 aagacggcgg ccctccgcca cgtgatgcca cgtccagccg tgcggagtgg ccaccggagc
    22801 gatcgtgtcc cacaactcgt ggccggcggc agcctgcgcc gcgttggcgg acacataatc
    22861 cgtcaaccgc aactcatcca ccccgaaccc cgcgggcggc tcggcgatct cggccgcggc
    22921 gcgcgcgtac gccgagaaat ccgggaaacc acgcccgtcc acccgcaccc cacccggatg
    22981 gcgcgcggca cgaaccgggt cggggaaacg cacgagctga ccggcatagg ccgcgttggg
    23041 cggcgcggca cgtcccccgg cctgggatcc cggaggcggc gccccctgcc cgagccgacc
    23101 tgtcgtcatg gcggttgccc cctgcacctt gctacctacg gaggatggcg gatggcgaca
    23161 gcctaagcgg tcacgcaacg ggggtcaccg gcccttcccc atccgtgacc agccgacacc
    23221 cgccagtgac catggaaggc tgtacgcgcc gagacacagc cccagctacc gcttcagggg
    23281 cgctatttgg caggctgtca ccgcaactcg ggggattgca cggaggggaa gcaccaccat
    23341 gcacaccgca caaaccggta caacaaccgg caactcggca ggtacggcgg gtatggcagc
    23401 agccaaggcc accaccgcga ccgctaccac cggccccacg gccggcaccg ccaccggcac
    23461 gtccggccac ccgtccacga ggacaccggc cgagacggag ttcggcgcgc ccgccgaccc
    23521 gcgctccaca ccccacgcca cgccccaccc gcgcacgccc ggcgcagccg cacagccgac
    23581 cgaggaaccg gccacgaccg gcgacgggca gggagccacc acgggccacc ggcccaccgc
    23641 cgacccgcgc accggcccca ccgcaccctc ctgggcccgc gccgacacgc cggaaccccg
    23701 cacggagaac caggccgccg ccacccccac ggcaccgtcc tgggcccgcg ccgacacgcc
    23761 cgacccgcaa acagaaacca cggccgccgc cccggccacc accacgctca ccgctcccgc
    23821 ccgactcccc gacgacgacc cgcgcgtcga ctggagcagc gacagcagca aaccccccac
    23881 actccgccac cgccgcgacg gcatcctccc caccgtcgcc gccgcactct ccgtacgcgg
    23941 caccacactc acctgcaccg cgggccgcgc cgaccagcgc ccacagctcc acccgctcgt
    24001 ccaggacttc ctcgacaccc tcaccagcgg acagcgcgaa cgattcacgg gacgctgcgc
    24061 ggaagcactc ctcatctccc gcagaatcac cgccgccgac gccgcacgcg ccaccaaatc
    24121 caaacgcgcc gcacgcaaac ccatgaccgc gggtgaagcg cgcaaagcgc tcaaacacgc
    24181 caaactcacc acccgtcaca tccgcgagga cggcgacccc ctccacggcg gcttcgcacc
    24241 gccctgccgc tcctgcaccg cgctcaccgc ccacttcggc gtacgcgtca tcgaaccgac
    24301 cccgcacgag gactgagcga ggcatcaccc agcccatgca cgacgacgac cccacccaca
    24361 cccccagcgc acgcttcccc cgccccgtcg acgccgtcct gcgcaccgcg ggatggcagc
    24421 cgggacgctg ggacatcagc caggcggagg tctgggccga caccctccgc ggacacacct
    24481 cacccgcggg ccacctgcac accgtctccc ccgccgcggt ggaagcctgg gccgaattcg
    24541 gtggcctcca catcgtcccc ccaggacccg gccgcgagat cgctccgacc cctttccaca
    24601 tcgaccccat gcacggcctc cacatggcgc gcaccctcgg cgacctcggc ctcgccctcg
    24661 acaccgaggt ctgccccctc ggcacagaac ccgagagccg cacactcctc gccatcgaca
    24721 gccacggccg cgtctacgga ctcgaccaca gcggcgactg gtacctcggc gccgacatcg
    24781 accagggcct cgccaccctc gtctccggca cccgccccag cagactcacg accacctgag
    24841 ggcaccacga gggcaccgcg agggcaccac ggcgggacac gggacattgg gtgcgggacg
    24901 cccggcgtcg gacaccgggc cacgaaccga gtgccggaca ccgggtgccg ggcgacgaat
    24961 gccgagtgcc gtgcgccgga caccggacga cgagccatga gcgacgagcc atgagcgacg
    25021 agtgccggac accgggtgcc gggcagacct cggggggcac ccccgggccc accccgggat
    25081 cgctccagga cccggcaccg acgccccccc ttgcgc
//
