LOCUS       NZ_CP045178            20927 bp    DNA     linear   CON 25-NOV-2024
DEFINITION  Streptomyces tsukubensis strain AT3 chromosome, complete genome.
ACCESSION   NZ_CP045178
VERSION     NZ_CP045178.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces tsukubensis
  ORGANISM  Streptomyces tsukubensis
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8615214)
  AUTHORS   Cao,G., Zhong,C., Fu,J., Zhang,P., Liu,M. and Zong,G.
  TITLE     Complete genome sequence of Streptomyces tsukubaensis AT3
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8615214)
  AUTHORS   Cao,G., Zhong,C., Fu,J., Zhang,P., Liu,M. and Zong,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-OCT-2019) Shandong Medicinal Biotechnology Center,
            Shandong First Medical University, 18877 Jinshi Road, Jinan 250062,
            China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 01-OCT-2019
            Assembly Method :: SOAPdenovo v. OCT-2019; SPAdes v. OCT-2019
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 997.0x
            Sequencing Technology             :: Illumina HiSeq; PacBio RSII
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_009296025.1-RS_2024_11_20
            Annotation Date                   :: 11/20/2024 08:40:01
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,005
            CDSs (total)                      :: 6,919
            Genes (coding)                    :: 6,691
            CDSs (with protein)               :: 6,691
            Genes (RNA)                       :: 86
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 65
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 228
            CDSs (without protein)            :: 228
            Pseudo Genes (ambiguous residues) :: 0 of 228
            Pseudo Genes (frameshifted)       :: 76 of 228
            Pseudo Genes (incomplete)         :: 184 of 228
            Pseudo Genes (internal stop)      :: 10 of 228
            Pseudo Genes (multiple problems)  :: 38 of 228
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 05:10:03
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2169118
            Orig. end                         :: 2190045
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP045178.1.
            Bacteria and source DNA available from Dr. Guangxiang Cao.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..20927
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="CDPS"
                     /region_number="9"
                     /rules="CDPS"
                     /tool="antismash"
     cand_cluster    1..20927
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="CDPS"
                     /kind="single"
                     /product="CDPS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20927
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="False"
                     /core_location="[10000:10927](+)"
                     /cutoff="5000"
                     /detection_rule="CDPS"
                     /neighbourhood="10000"
                     /product="CDPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10927
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="CDPS"
                     /neighbourhood="10000"
                     /product="CDPS"
                     /protocluster_number="1"
     misc_feature    115..128
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 15.58"
                     /tool="antismash"
     misc_feature    complement(115..130)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.17"
                     /tool="antismash"
     gene            232..693
                     /locus_tag="GBW32_RS09530"
                     /old_locus_tag="GBW32_09530"
     CDS             232..693
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003969495.1"
                     /locus_tag="GBW32_RS09530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_09530"
                     /product="lamin tail domain-containing protein"
                     /protein_id="WP_077973830.1"
                     /transl_table=11
                     /translation="MRIRSAAISALAAAALTGSLFASAPAQAAAHRSGLHIGLVQFNSP
                     GKDTRTNASLNGEWVNIHNNSRSPLQLKGYKLKDNTGYTYTFGSYRVGAGKTVKVRTGK
                     GKNVSGVRYWGRGSYVWNNTGDKARLIKPNGSLRDSCSWGGKGSTKNCH"
     misc_feature    complement(789..804)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.52"
                     /tool="antismash"
     gene            790..1656
                     /locus_tag="GBW32_RS09535"
                     /old_locus_tag="GBW32_09535"
     CDS             790..1656
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0016853 - isomerase activity [Evidence
                     IEA]"
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006373389.1"
                     /locus_tag="GBW32_RS09535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_09535"
                     /product="PhzF family phenazine biosynthesis protein"
                     /protein_id="WP_077973831.1"
                     /transl_table=11
                     /translation="MTTDTEILRYTAFSNDAAGGNPAGVVLDASALDETAMLAVAADVG
                     YSETAFLTAPAEGSGEPGRAFTVRYFSPKAEVSFCGHATVATAVALAERHGVGDYLFAT
                     PAGDVPVTVDRVGGDLRATLTSVEPHIEEADKDDVAQALDALGWRADDLDPAFPPRIAY
                     AGARHLVLAATTRQRLADLSYDFATLESLMRRLDLTTVQLVWRAGDSVFHVRDPFPVGG
                     VVEDPATGAAALAFGAYLRELALVPADAELTLWQGEDMGRPGELTVTLRDGDPRVRVSG
                     AAVAIPG"
     gene            1868..2419
                     /locus_tag="GBW32_RS09540"
                     /old_locus_tag="GBW32_09540"
     CDS             1868..2419
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019064342.1"
                     /locus_tag="GBW32_RS09540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_09540"
                     /product="DoxX family membrane protein"
                     /protein_id="WP_227025062.1"
                     /transl_table=11
                     /translation="MTCFDRRDMGLFLLRLGTGGVLAAHGSQKLFGWFGGGGVEATGNA
                     MESMGFTPGRANALAAGLGEAGGGALLALGLATPAAGAAAAGTMGAAAAVHAPGGFFAQ
                     GGGYEYPAFLGFAAAALSVTGPGRISLDHAMGHTLNKRWMMPAALVGCAAATLTVVAAR
                     NKQVRQKAQETASAEETAAA"
     misc_feature    complement(1887..1897)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.79"
                     /tool="antismash"
     gene            2738..3637
                     /locus_tag="GBW32_RS09545"
                     /old_locus_tag="GBW32_09545"
     CDS             2738..3637
                     /GO_function="GO:0008276 - protein methyltransferase
                     activity [Evidence IEA]"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0018364 - peptidyl-glutamine methylation
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018093412.1"
                     /locus_tag="GBW32_RS09545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_09545"
                     /product="putative protein N(5)-glutamine
                     methyltransferase"
                     /protein_id="WP_077973832.1"
                     /transl_table=11
                     /translation="MSDTTSHPAPSDRSASSAYPSASDPHLSATDRSVPSALSRSTVVA
                     RLRAAGCVFAEDEAELLLGAAGTPADLAAMVDSRAGGLPLEHVLGWAEFCGLRVTVGPG
                     VFVPRRRTEFLVRRAVALTVDHVAGRPVVAVDLCCGSGAVGVALAAALGAVELHAADVE
                     PAAVRCARGNITAMGGTVHEGDLFAALPRSLRGRVDVLAANVPYVPTDEVELLPSEARV
                     HEPLVALDGGSDGLDILRRVAGEAARWLAPGGHVLVETGERQAEAAVEAFRAGGLVPEV
                     SADDALYSTVVTGRRPLR"
     gene            complement(3796..4527)
                     /locus_tag="GBW32_RS09550"
                     /old_locus_tag="GBW32_09550"
     CDS             complement(3796..4527)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (9-183). E-value: 3.9e-14. Score:
                     44.9. Matches aSDomain:
                     nrpspksdomains_GBW32_RS09550_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015580355.1"
                     /locus_tag="GBW32_RS09550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_09550"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_077973833.1"
                     /sec_met_domain="adh_short (E-value: 2.5e-34, bitscore:
                     117.5, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSGIEGKAIAITGASSGIGEATALLLAERGARLVLGARRPERLEA
                     LVGRIEKAGGEAVWARTDVTRREDLSGLVQLARDQYGKLDVLVSNAGVGLISPLDELRV
                     EDWEEMIDVNLKGVLYGIAAALPVFREQGYGHFVNTLSTAGLRIVPLQSVYAGTKNAVR
                     TIAEALRQEAGDSLRVTSVSPGAVRTDFTERMDPAMKDQVDKLMEIALPPDAVARAIAF
                     AIEQPDGVDVGDVVVRPTAQG"
     aSDomain        complement(3979..4500)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_GBW32_RS09550_PKS_KR.1"
                     /evalue="3.90E-14"
                     /label="GBW32_RS09550_PKS_KR.1"
                     /locus_tag="GBW32_RS09550"
                     /protein_end="183"
                     /protein_start="9"
                     /score="44.9"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="AITGASSGIGEATALLLAERGARLVLGARRPERLEALVGRIEKAG
                     GEAVWARTDVTRREDLSGLVQLARDQYGKLDVLVSNAGVGLISPLDELRVEDWEEMIDV
                     NLKGVLYGIAAALPVFREQGYGHFVNTLSTAGLRIVPLQSVYAGTKNAVRTIAEALRQE
                     AGDSLRVTSVS"
     CDS_motif       complement(4411..4497)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_GBW32_RS09550_0001"
                     /evalue="4.10E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="GBW32_RS09550"
                     /protein_end="39"
                     /protein_start="10"
                     /score="16.3"
                     /tool="antismash"
                     /translation="ITGASSGIGEATALLLAERGARLVLGARR"
     misc_feature    complement(4633..4647)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 16.52"
                     /tool="antismash"
     gene            4663..5253
                     /locus_tag="GBW32_RS09555"
                     /old_locus_tag="GBW32_09555"
     CDS             4663..5253
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016432737.1"
                     /locus_tag="GBW32_RS09555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_09555"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_077973834.1"
                     /transl_table=11
                     /translation="MPREAGRPLRADAQRNRDKILAAAVRVFSEEGLDAHFERVAREAG
                     VGTGTLYRNFPTREALIEAAYRNEVARLCDAVPGLLAELSPPEALRAWTRRFIDYATAK
                     LGMADALRAVVVSGTNPYADSHELIQTALSALMDANTAAGTIRADISPTDMFAALAGIA
                     LTSARPELRAQAERLLDLTLDGLRPTAARPPES"
     misc_feature    complement(5310..5326)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 19.23"
                     /tool="antismash"
     gene            5693..6370
                     /locus_tag="GBW32_RS09560"
                     /old_locus_tag="GBW32_09560"
     CDS             5693..6370
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF041196.1"
                     /locus_tag="GBW32_RS09560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_09560"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_143621566.1"
                     /transl_table=11
                     /translation="MHTRHTLVLTAATLFEQRGFARTRLSEVSSHAGVSSGALHFHFAS
                     KDVLANVVQEYSAATLHRAASDARDRSDDALQGLVDITHAVAARLNTDVVARAGLLLDW
                     DAAWEGGHRLGEEWRDCVRAELLTARAEGALADEVSLADIEVSVVAVTTGFEALARQDP
                     TWLSHQPLTGFWRLMLPQITAPAWTAPTDPAGAPVHRQEREEAAPRRALAAAGSNIGSY
                     QVS"
     gene            complement(6477..7145)
                     /locus_tag="GBW32_RS09565"
                     /old_locus_tag="GBW32_09565"
     CDS             complement(6477..7145)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006608007.1"
                     /locus_tag="GBW32_RS09565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_09565"
                     /product="ScbR family autoregulator-binding transcription
                     factor"
                     /protein_id="WP_077973836.1"
                     /transl_table=11
                     /translation="MAKQDRAVRTRRRITEAAAEVFEREGYQAATITEILRTAGVTKGA
                     LYFHFQSKEDLAQAVLHEQRQEEAVRPQEVRLQELVDGGLVLAHRLAGQPLVRASIRLT
                     LDPYAQGVDRRAPFRQWTERNLKVLLAAEAAGELLPHVDPAATAELCVASFAGLQFMSQ
                     VMSDYGDLSERLSVFQHHLMPSIATPYALAHLDLSPERGRRLVAEAVDRGGEGIEGLRV
                     "
     gene            complement(7412..7603)
                     /locus_tag="GBW32_RS09570"
                     /old_locus_tag="GBW32_09570"
     CDS             complement(7412..7603)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015578997.1"
                     /locus_tag="GBW32_RS09570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_09570"
                     /product="CsbD family protein"
                     /protein_id="WP_077973837.1"
                     /transl_table=11
                     /translation="MGNESAMNKIAGKAKEMFGKATGDKRKQSEGKTDQVKGKAQGAVD
                     GAGDRAQGMKDSIKRDDS"
     gene            7879..8622
                     /locus_tag="GBW32_RS09575"
                     /old_locus_tag="GBW32_09575"
     CDS             7879..8622
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025382.5"
                     /locus_tag="GBW32_RS09575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_09575"
                     /product="DUF4232 domain-containing protein"
                     /protein_id="WP_143621568.1"
                     /transl_table=11
                     /translation="MKTTRRTVRSVRTAGLVAVTAAAALSMTACQGDGVKDAGAASSNA
                     SASDDATAKDSGSAGKDSGSAGSDAQGGSTGSSSASTGGDGKRSGQGGDSGAGTQNKDG
                     AVDSPDAKRTTCDLGTTRVRLQETGGSAPVILLKATNTGSTRCDLYGHPFLGYPDAQSP
                     VQVGGGPPQAVVSLEPGKSAYASLSLEKGSGNNMHREKELTVELADSKQHGTGSTASLT
                     APGAGLALSDASTVSYWNTTPEQTM"
     gene            complement(8790..9104)
                     /locus_tag="GBW32_RS09580"
                     /old_locus_tag="GBW32_09580"
     CDS             complement(8790..9104)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016471397.1"
                     /locus_tag="GBW32_RS09580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_09580"
                     /product="DUF6092 family protein"
                     /protein_id="WP_107503048.1"
                     /transl_table=11
                     /translation="MNSGTSSRPLPTELAEQIALLAAFLLSSGRGLLEEPTAYGPARCA
                     DGARRTLELLERYGPCDARLVALRTRLEEAMSGPMGEVDLVALLDDACDRMAEVLSENR
                     "
     gene            complement(9058..9681)
                     /locus_tag="GBW32_RS09585"
                     /old_locus_tag="GBW32_09585"
     CDS             complement(9058..9681)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00881"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1159: dihydropteridine reductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016572569.1"
                     /locus_tag="GBW32_RS09585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_09585"
                     /product="nitroreductase family protein"
                     /protein_id="WP_077973839.1"
                     /sec_met_domain="PF00881 (E-value: 2e-11, bitscore: 42.9,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGPPTAGLSTTTSEKGRAAIDSPLPFSAFLDVLTSRTAVRQYTEE
                     PVDDAMLDRLLDAMLSAPTAANKRAWAFVAVRDPAQVRRLRAFSPGMLGLPPLAVVACF
                     DRRKVIHDAESFYDTGMLCLAMAVQNLLLAAHAAGLGGCPVSSYRSAPISRLLRLPPHL
                     EPLLLVAIGRPAHPRQRADQLCERHEVIRHEFWNQQPSTADGTG"
     misc_feature    complement(9610..9612)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(9718..9728)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     misc_feature    9869..9882
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 18.56"
                     /tool="antismash"
     gene            10001..10927
                     /locus_tag="GBW32_RS09590"
                     /old_locus_tag="GBW32_09590"
     CDS             10001..10927
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) CDPS:
                     CDPS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR04539.1"
                     /locus_tag="GBW32_RS09590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_09590"
                     /product="tRNA-dependent cyclodipeptide synthase"
                     /protein_id="WP_077973840.1"
                     /sec_met_domain="CDPS (E-value: 3.6e-64, bitscore: 215.1,
                     seeds: 17, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNAERADDVVVSPRARISEFTECTETTETTETTGATKSAESAKFG
                     EPAEPAEPAESAESTERRIGQCGLLPSATGAFRSNPLTERCRSIEARGDHILIGVSTGN
                     SYFSTDRLTQLLRWSQKRFRVVDVICADTCIDTMLIAEGCAESEARQRAKRRITNVRRR
                     IRHAVRDSRPGHASTTTHLLSDFERSDAYLAVRTRVLNTLEDHPPFTRACQAMVRCFLP
                     AGAGDDSDDLSPRMRAGLAYVVNELPFVIDTPGILGPPTSLSCYHVLPPAVRHLYLESG
                     GLTPVEGQGFAVITPVPPAGSEEEGSA"
     misc_feature    10205..10207
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            10924..12135
                     /locus_tag="GBW32_RS09595"
                     /old_locus_tag="GBW32_09595"
     CDS             10924..12135
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019889608.1"
                     /locus_tag="GBW32_RS09595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_09595"
                     /product="cytochrome P450"
                     /protein_id="WP_077973841.1"
                     /sec_met_domain="p450 (E-value: 1.1e-12, bitscore: 46.1,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEVPTPVVPDLDFPLSRRGDTVPAECAWLRRKRPVARVRTMTGD
                     LAWLVSTHELATRVLQDDTFSMLRVGEAGAPSQYAPTFPVELRNSMARFSDDGLRGAIM
                     KAVSPPVVAASADGMRRRADELIDALVADGPPLDFKQHFTDPYTVSVMCAVLGLPDTDW
                     RSMLACLDITIMTAPEPFEGARANWDKGIARMTTRLREPGAVRAAGLLGSLARLREADS
                     ADPVPDDVLAMALHTLFEAGAASAATFLLHATLLLMCHPEQADALRDHPEHLGTAVEEL
                     LRHNLSIGDGLPRIATRDIRLGDADIKEGDLVLVLVEGANHDPTAFTSPERLDLRRTPN
                     PHLSFGAGSHYCPATTLARAHADIALEAVLRRLPDLRLAIPVEQLNWRTGWIKRTCERL
                     PVLW"
     gene            12178..13107
                     /locus_tag="GBW32_RS09600"
                     /old_locus_tag="GBW32_09600"
     CDS             12178..13107
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 2OG-FeII_Oxy"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF015150.5"
                     /locus_tag="GBW32_RS09600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_09600"
                     /product="2OG-Fe(II) oxygenase family protein"
                     /protein_id="WP_077973842.1"
                     /sec_met_domain="2OG-FeII_Oxy (E-value: 2e-12, bitscore:
                     46.2, seeds: 135, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSPTSADPPAAATVTPSDSTGLCEAALEHGRIDGGYLVFDDGPPA
                     LGRALQDGMFLVDIPADVAVATGDAFAEHFFRGPTSPPYGEFRDITSDSFGDPLLGFHQ
                     RANKSEQFLLERRFWDTRFPDEMTALGEAMTRLSSHIMAGVLAYSGIPYDRWGRATGDC
                     VLLGGTYHLTFNHYLPTHLDLGLNPHQDDGFLTILRATTPGLEIDRGEGTWQTVTPPPG
                     CFVVNFGLAMEILTSATRTPATAVLHRVSGQRGDRFSFAHFASVTQTPGADSGVHRYLP
                     ATGALERVCTAQDLLHSDYAASDVATGT"
     gene            13273..14652
                     /locus_tag="GBW32_RS09605"
                     /old_locus_tag="GBW32_09605"
     CDS             13273..14652
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018562446.1"
                     /locus_tag="GBW32_RS09605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_09605"
                     /product="cytochrome P450"
                     /protein_id="WP_077973843.1"
                     /sec_met_domain="p450 (E-value: 8.5e-80, bitscore: 267.4,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVSTEIELRPVPGPRGLPLLGNLPAFGKDPLSFFSSLRDEYGDA
                     VTWSLGSRPALFVAHPAHIAELMAEVEHTFEPGDVGWTFAKVCGESILRSRGAQWRRKR
                     AMVQPTVRPKQVRGYATTMVECAQQRGNGWREGGRIDVGREMERITQRIVSRTLFGNDL
                     GARADVLGESLSAIEWEMGAEVRSLRLFLPPWVPSAARRRLLAELAVVDEEVGRLVRTR
                     RQAMDRGEEREREDLLSRLLAARDGQGQRLSSKEVRDEAVTLWIAGNGTSTTALTWTWY
                     LLARNPGARTKLTAELQRVLGDRSPSFEDYESLTYTRQVIKESLRLYPPAWVIPLRAKA
                     GARLGGHAIRAGDAVWCSQWVTHRDPRWFTDPLAFRPERWDGESTANTSWQTWFPFGTG
                     PRTCVGARFAQVETALVLATLARRWHLEVDPGEVVPQAVQLLQPSTPVRATVRAAAPPS
                     T"
     gene            complement(15189..15833)
                     /locus_tag="GBW32_RS09610"
                     /old_locus_tag="GBW32_09610"
     CDS             complement(15189..15833)
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007500697.1"
                     /locus_tag="GBW32_RS09610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_09610"
                     /product="response regulator transcription factor"
                     /protein_id="WP_077973844.1"
                     /transl_table=11
                     /translation="MIRVLIADDEALMRAGIRLILENDDEVRIVAEAQDAREAVEACRV
                     HPVDVALLDIRMPGDGITGAAEIARHSPRTRVVMLTAFGEEPSVTRALRAGAHGYLLKD
                     TGPRDLIDAVRRAAAGEPVLAPQVTRQLVDFRVRSGHGSDAAARRIENLTPAERNVLRL
                     MGAGLSNAGIAAQLHLSSGTVKAHIGSILTRTDCTNRVQAAVLAQQAGLLG"
     gene            complement(15838..17271)
                     /locus_tag="GBW32_RS09615"
                     /old_locus_tag="GBW32_09615"
     CDS             complement(15838..17271)
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016472555.1"
                     /locus_tag="GBW32_RS09615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_09615"
                     /product="sensor histidine kinase"
                     /protein_id="WP_077973845.1"
                     /transl_table=11
                     /translation="MRPWRRIRREAAANRDAVRAAPRRTVVIESVLAGLVLLGTLAPLP
                     LIPPAHPVTTILLGVWAALLVPARRVYPALTVMGCVPVVAGDNVWATVVVPCVVWSAVR
                     RVTPARRAWGVAGASGAGAVLVSIAAASVGGLPKMSYLAAGAGASALFILLPALSGLML
                     GRRRPLTGLLRERNAYLEQARFLTEETARMEERARIAAEMHDLLGHRIGLISVHAGALQ
                     LAVERQAPPLAARAEFLHTTAGTAMEELRGILGVLRHQTGEETGERGTREDLSALVADS
                     RNAGADAELHWNATGAMDADARTRQAVHRVTREGLANALKHASGAPVRVTFHDEGDTVV
                     VAVVNDAPPGPCSRGDGNRSGLVGLQERVRLLGGVLDAGPRPEGGFALSARIPAMPDMP
                     PVYATSAGSVSGGAGSRPPLSGGAGSGPPLSGGAGSRPPLSTEVLTWPRLLGGGCAAML
                     VLLPTVGGSLVLLIMAVLH"
     gene            complement(17423..18754)
                     /locus_tag="GBW32_RS09620"
                     /old_locus_tag="GBW32_09620"
     CDS             complement(17423..18754)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007500695.1"
                     /locus_tag="GBW32_RS09620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_09620"
                     /product="Clp protease N-terminal domain-containing
                     protein"
                     /protein_id="WP_077973846.1"
                     /transl_table=11
                     /translation="MDQRTSDRDAGATTQFERDVVELLGEAMSKAAKQQREDVGTESVL
                     SALVSGESAAGSAIAPGMRASGSLGGSIGCRGTSVWVSADAGDGAAGDPDDEREIDALW
                     REVRHEETQRQRRKNRKNQKNQKDQRNQNDQRQQRKQGEEQGSDQVQVQVQVQVQDQEP
                     ENVAIPPMTGALRVCLREALEAARDEGTLSVRVRHVARALVESPDTRAREAMVVEKLDI
                     GAASAALDALRGSDEVPEPAAVLVLRKAGTFGKSGNPLSRKFTAWILGGGAGFGSAVVA
                     VVRSEARRGAVRRGASEPRPVDVLLGILTLDRSLTVAGRELPEKLTGANQGARLLRRHG
                     ARQDAVARVMLPSTGVAEEAPVEVVGTAEFEQRLLHVTQYTASAQGSSTVGTTHLLAAL
                     LDGTGTDAESAAEIERVLTESGVDVAGLRAEPELQVPGGAAQAA"
     gene            19089..19685
                     /locus_tag="GBW32_RS09625"
                     /old_locus_tag="GBW32_09625"
     CDS             19089..19685
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019064431.1"
                     /locus_tag="GBW32_RS09625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GBW32_09625"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_077973847.1"
                     /transl_table=11
                     /translation="MSHDDRSPTTATRPKRADARRNEVVLLDAAGAVFVRSGVEAPIRD
                     IAAEAGVGTATIYRHFPTRADLILAVYHHQVEALAEAGAAALTESTHPHASLGRWFEQF
                     VDFLVTKHGLAAVLQSDDPCYDPLHSYFLERIVPVCAQLLDAAATAGEIHPGQDPYELM
                     RGVASLCAGVGTTHQYQYNARRLTGILIAGLHRSA"
     misc_feature    complement(20412..20426)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 17.52"
                     /tool="antismash"
ORIGIN
        1 atgtgcagtt cgcgaccgtg ctggcgacgg cgatgccgta catcgggcgg gggtgacccg
       61 gagggggccg atccggacgg caccggttcg ggcgggtccg agccgggcgt gcgcgataaa
      121 gatgatcacc ggaaaccttt acaaacggaa tatgtgatat cgcggaatgt ggcgctggga
      181 acgggctact ctcagtagcc cttcaccaga actgcacatc tggagcacat cttgcgcata
      241 cgttccgcgg cgatctccgc attggccgcc gccgcactga ccggttctct gttcgcctcg
      301 gcacccgcac aggcggcggc gcaccggagt gggttgcaca tcgggctggt gcagttcaac
      361 agtcccggca aggacacccg caccaacgcg tcactgaacg gcgagtgggt caacatccac
      421 aacaactccc gctcacccct ccagctcaag ggctacaagc tgaaggacaa caccggctac
      481 acctacacct tcggcagcta ccgcgtcggc gcgggaaaga ccgtcaaggt ccgcacgggc
      541 aagggaaaga acgtgtccgg cgtccgctac tggggccgcg gctcctacgt ctggaacaac
      601 accggcgaca aggccaggct gatcaagccg aacggctcgc tgcgcgactc ctgctcctgg
      661 ggcggcaagg gttccaccaa gaactgccac tgacccgcga gcggggcccc cagcccccag
      721 acgcgggccg cggtccggtg cgtctctcgg cggggaatgc gccggaccgc gcggcggttg
      781 tgcccgaatg tgacgacaga cacagaaatc ctccggtaca ccgccttctc caatgacgcc
      841 gcgggcggca accccgcggg cgtcgtcctg gacgcctccg ccctcgacga gacggccatg
      901 ctcgccgtgg ccgccgatgt cgggtacagc gagacggcct tcctcaccgc gccggccgag
      961 ggctcgggcg agcccggccg cgccttcacc gtgcggtact tcagccccaa ggccgaggtc
     1021 tccttctgcg gccacgccac ggtcgccacc gccgtcgcgc tcgccgagcg gcacggcgtg
     1081 ggcgactacc tcttcgccac ccccgcgggg gacgtcccgg tcaccgtcga ccgggtcggc
     1141 ggcgacctgc gagccaccct gaccagcgtc gagccgcaca tcgaggaggc cgacaaggac
     1201 gacgtggccc aggccctcga cgcgctcggc tggcgcgccg acgacctcga ccccgctttc
     1261 ccgccgcgca tcgcctacgc gggcgcacgt cacctcgtcc tcgcggcgac gaccaggcaa
     1321 cggctcgccg acctgtcgta cgacttcgcc accctggagt cgctcatgcg ccggctcgac
     1381 ctgaccacgg tccaactggt gtggcgtgcg ggtgactccg tcttccacgt gcgtgacccg
     1441 ttccccgtgg gcggcgtggt cgaggacccc gccacgggcg cggcggcgct ggccttcggc
     1501 gcttacctgc gggaactcgc cctcgtcccc gccgacgcgg agctgaccct gtggcagggc
     1561 gaggacatgg gcaggccggg agagctcacg gtgaccctgc gggacggcga cccccgggtg
     1621 cgggtcagcg gggcggcggt ggccatcccg ggctgacagg ccaggacgcg gggtcctcac
     1681 cgcggaggcg tagcctcgtg atcatcaccc gaacgggtga gctggcggag tgcacggcgg
     1741 gccaggggcg gatcgtggga gacggagttc tccgcgcgtc cgcccctggc acccggccgg
     1801 ctccggcggc tcgctggtga tccctgattc ttggtttctg cttccaatgt gtttctgagg
     1861 agacgtagtg acgtgcttcg accgacgtga catgggactg ttcctgctgc gcctgggcac
     1921 cggcggggtc ctcgccgccc atggctcgca gaagctcttc ggctggttcg gcggcggggg
     1981 tgtcgaggcc acaggcaacg cgatggagtc catgggcttc acacccggca gggcgaacgc
     2041 gctggccgcc ggtctcggtg aggcgggtgg cggcgcgctg ctggccctgg gcctcgccac
     2101 ccccgcggcg ggcgcggcgg cggcgggaac catgggcgcc gccgccgcgg tgcacgcccc
     2161 cggcggcttc ttcgcgcagg gcggcggtta cgagtacccg gcgttcctcg gtttcgccgc
     2221 cgccgcgctc tccgtcacgg ggcccggccg tatctcgctc gaccacgcga tgggccacac
     2281 cctcaacaag cgctggatga tgcccgcggc cctggtgggc tgcgccgcag cgacgctcac
     2341 ggtcgtggcc gcccgcaaca agcaggtgcg gcagaaggcc caggagacgg cgtcagccga
     2401 ggagacggcc gcggcctgac gtcggcggat gcggccggcg ccgcggggcg gcactcacgg
     2461 atcgacggtg agtgccgccc cgccccgctc cccgcaccgc ccctgccccg tgtcccgtga
     2521 cagcggggct cgcaggcgcg tgggcacgca ggcacgtggc gacacctgaa gagacggacc
     2581 cgggcggggt agggtgtcgg ctccagcagt ggacatgaag gaggtgggcc ccattaccgc
     2641 tgtagcaggc cgggtgctcg cccctcgcgg ccgtgcggtg cgcacggcat aggtgaccgc
     2701 gggagcgccc atcggcgtcc cggaaggttc ttgtcccatg tctgacacca cgtctcaccc
     2761 cgctccctcc gaccggtccg cgtcttccgc gtacccgtcc gcgtccgacc ctcatctgtc
     2821 ggccaccgac agatcagtgc cgtccgcgct ctcccgttcc accgtcgtgg cccggctccg
     2881 cgcggccggt tgtgtcttcg ccgaggacga ggcggaactc ctcctcggag cggccggtac
     2941 gcctgccgac ctcgccgcca tggtggacag cagggccggc ggacttcccc tcgaacacgt
     3001 ccttggttgg gcggagttct gcggcctgcg ggtcaccgtc ggtcccggtg tcttcgtgcc
     3061 gcgccgccgc accgaattcc tggtgcggcg cgccgtcgcg ctcaccgtgg accacgtggc
     3121 ggggcgcccg gtcgtcgccg tcgatctgtg ctgcggctcg ggggcggtgg gcgtggcgct
     3181 cgcggcggcg ctcggcgccg tcgaactgca cgcggcggac gtcgaaccgg cggcggtacg
     3241 gtgcgcacgc ggcaacatca ccgccatggg gggcaccgtc cacgagggcg acctcttcgc
     3301 cgcgctcccc cgctccttgc ggggccgcgt cgacgtactg gccgccaacg tcccctacgt
     3361 ccccaccgac gaggtggagc tgctgccctc ggaggccagg gtccatgagc cgctggtggc
     3421 gctggacggc gggagcgacg ggctcgacat cctgcgccgg gtggcggggg aggccgcgcg
     3481 ctggctggct ccgggtggcc acgtgctggt ggagacgggc gaacggcagg cggaggcggc
     3541 ggtcgaggcg ttccgcgcgg gcgggttggt tcccgaggtg tccgccgacg acgcgttgta
     3601 ctcgacggtg gtgacaggac gccgtccgct ccgctgagcg cgtcggtacg gagccggtcc
     3661 ggcagtcggc acatgcctcc ccctcgccct cctgactcgc gtgcccctcc cccctgtgag
     3721 acccgggcgt ggcgccctgg cacgtgatcg ggcccgcccc cgagcgccgg acctcctgcc
     3781 tctgggcggc gggacctacc cttgggcggt ggggcggacc acgacgtcac ccacatcgac
     3841 accgtccggc tgctcgatgg cgaaggcgat ggcgcgggcc accgcgtccg gcgggagagc
     3901 gatctccatc agcttgtcga cctggtcctt catggccggg tccatgcgct ccgtgaagtc
     3961 cgtgcggacc gcgccgggcg agacgctggt gacacgcagg ctgtcgcccg cctcctgtcg
     4021 cagggcctcg gcgatggtgc gtacggcgtt cttggtgccc gcgtacaccg actggagcgg
     4081 cacgatacgc agcccggcgg tggacagggt gttgacgaag tgcccgtagc cctgttcccg
     4141 gaagacgggg agggccgcgg cgatcccgta caggacccct ttgaggttga cgtcgatcat
     4201 ctcctcccag tcctcgacgc gcagctcgtc caggggggag atcagcccga cccccgcgtt
     4261 gctgaccagt acgtcgagct tgccgtactg gtcacgggcg agctggacga ggcccgagag
     4321 gtcctcgcgc cgcgtcacat ccgtgcgggc ccagacggcc tcgccgcccg ccttctcgat
     4381 gcggccgacg agggcctcaa gccgttcggg gcggcgtgcg ccgaggacga gtctcgcgcc
     4441 ccgctcggcg agcaggaggg cggtcgcctc gccgatgccg ctgctcgcac ccgtgatcgc
     4501 gatggctttg ccttcgattc ccgacatgac tgacaatcct tccgtaagcc gagcggagtg
     4561 gtggcaggcc gtgccctacc gtggaagtgg aggccccgcc acttcttcca cgataagtgg
     4621 cggcggctcc acttagcaac tggagaccga ggagagccac tgatgccccg agaggcggga
     4681 cgcccactga gggctgacgc acagcggaac agggacaaga tcctggccgc cgccgtacgc
     4741 gtgttcagcg aggagggact cgacgcgcac ttcgagcgcg tggccaggga agccggcgtg
     4801 ggaaccggca ccctctaccg caacttcccg acccgggagg cgctgatcga ggccgcgtac
     4861 cgcaacgagg tggcccgact ctgcgacgcg gtgcccggcc tcctcgcgga gctgtcgcca
     4921 ccggaggccc tgcgggcgtg gacgcgccgc ttcatcgact acgccaccgc caaactcggc
     4981 atggccgacg ccctgcgggc cgtcgtcgtg tcgggaacca acccctacgc cgacagccac
     5041 gagttgatcc agaccgccct ctccgccctc atggacgcca ataccgcggc gggcacgatc
     5101 cgggccgaca tcagcccgac cgacatgttc gccgccctcg cgggcatcgc cctcacctct
     5161 gccagacccg aactgcgcgc acaggcggaa cgactcctcg acctcaccct ggacggcctg
     5221 agacccacgg ccgcacggcc acccgagagc tgacccccgg accggacacc ccgacagctg
     5281 ggcacccaag gacccgcacc gcatcgactt gaccagttat caagcatccc ggcagggggg
     5341 tatgaagacg ggagccacag aggcaggctg acggaatgtc tcacaaccgg cacacctcag
     5401 ccatcgcgcg ccccgcctcg atcgacccgc tcgggaaaga taccggagtc gctgtttcta
     5461 cggctcggca cgttcgatct ttccgcaggc gacggaggat ccgctgctcc aggccggcgg
     5521 gggcacctcc agaagccacc gatcgagacc ggacaatcgc cttgagtaac ggcacaagag
     5581 accccaacgg ctgtttatca tcgacccgtt gaggcccacc ctccacaagc gccgcccccg
     5641 tgtaccccac cgagcgacag gagccgatga cgtgccacaa caggagaggg ccgtgcacac
     5701 ccgacacacc ctcgtactca ccgcagccac tctgttcgag cagcgcggct tcgccaggac
     5761 cagactcagc gaggtctcct cgcacgcggg ggtgagcagc ggcgcccttc acttccactt
     5821 cgccagcaag gacgtactgg ccaacgtcgt gcaggagtac tccgccgcca ccctgcaccg
     5881 cgccgcgagc gacgcgcgcg accggagcga cgacgccctc caggggctgg tcgacatcac
     5941 ccacgccgtg gccgcgcgac tgaacacgga cgtggtggca cgggccggac tcctgctcga
     6001 ctgggacgcc gcctgggagg gcgggcaccg gctcggcgag gagtggcggg actgcgtacg
     6061 ggccgaactc ctgacggccc gagcggaagg cgcgctggcc gacgaggtca gtctcgccga
     6121 catcgaggtg tccgtcgtgg ccgtcacgac cggtttcgag gctctggcca ggcaggaccc
     6181 cacctggctc tcccaccagc cgctgacggg cttctggcgg ctcatgctgc cgcagatcac
     6241 ggcacccgcg tggaccgcgc cgaccgatcc ggcgggggcg cccgtccacc gacaggaacg
     6301 tgaggaagcc gcacccaggc gcgcgctggc ggcagcgggg tccaacatcg gctcgtacca
     6361 ggtgagttga cccacctgga tgaccgtctc cccgagtgct gccggagagc tgagggagca
     6421 caggggtagc ggtcggcctc cgcctccccc gtggctcaga acccggccgc ggatcctcac
     6481 acccggagcc cctcgatccc ctcgccgccc cggtcgaccg cctctgcgac gaggcgccgt
     6541 ccgcgctcgg gcgagaggtc gaggtgggcg agcgcgtagg gcgtggcgat gctcggcatg
     6601 aggtggtgct ggaagacgga gagccgttcg gagaggtctc cgtagtcgct catcacctgc
     6661 gacatgaact ggagtccggc gaaggacgcc acgcacagct cggccgtggc cgccgggtcg
     6721 acgtgcggca gcagttcccc cgccgcctcg gccgcgagca acaccttcag gttccgctcc
     6781 gtccactgtc tgaacggggc gcggcggtcg acgccttgcg cgtacgggtc gagggtcagc
     6841 cggatactgg cccgtaccaa gggctgcccg gccagccggt gcgcgagaac gagcccgccg
     6901 tcgaccagtt cctggagccg cacctcctgc ggcctgacgg cctcctcctg gcgctgctcg
     6961 tgcagaacgg cctgtgccag gtcctccttg gactggaagt ggaagtagag ggcccccttg
     7021 gtgacccccg ccgttcgcag gatctccgtg atggtggccg cctggtatcc ctcacgctcg
     7081 aagacctcgg cagccgcctc ggtgatcctc cgacgggtgc ggaccgcccg gtcctgcttg
     7141 gccatgtcgc cctccagatc ccctcggcgc cggatcacgg cacctgcgtg gggtcacatc
     7201 gtccgccaga cgtgatccag agatcaacat tccaagaaac cggcctcccc gtattttgtc
     7261 ggcgccagtg cgtaccgcgt cagtgcgtac ccgacctgga cggccggcag ggcgccccga
     7321 ggccgtgacg ccgggagtcg gcgccacgcc gggcgatgga tccgggtgag gggtcctggg
     7381 cgcgacccgg agagcggcct caggcccggg ttcaggagtc gtcgcgtttg atggagtcct
     7441 tcatgccctg ggcacggtcg cccgccccgt ccacggctcc ctgcgccttg cccttgacct
     7501 ggtcggtctt gccttcggac tgcttgcgtt tgtcgccggt ggccttgccg aacatctcct
     7561 tggccttgcc ggcgatcttg ttcatggcgc tttcgttacc catgacggct cccttggctg
     7621 gatggtgcct gacctgtcca acgtaggtcg ccgctctgtc cggcgcgcgt cgagcaggtg
     7681 ggcgcggtgg aggtgcgggg gcggggagcc cttccccggc accggagggc gccgcgcgga
     7741 ggctgttaca gagtgcggac agaattccgt gaacaacccc ggccggatgg tcatcacagt
     7801 gaatgtaccg accagtgacc ggcggggcgc ccgaggagaa cgggtgaccc ggccacatcc
     7861 gacaccgtgg gggaccccgt gaagaccact cgccgcaccg tccgctccgt ccgcaccgcc
     7921 ggcctcgtcg cggtgaccgc cgccgccgcg ctctcgatga ccgcctgcca gggcgacggc
     7981 gtcaaagacg ccggggccgc ctcctccaac gcctcggcct ccgacgacgc gacggccaag
     8041 gactcgggct cggccggcaa ggactcgggc tcggccggct ccgacgcgca gggcggttcg
     8101 accggctcct cctcggcctc gacgggcggc gacggtaagc ggagcggcca gggcggcgac
     8161 agcggagcgg gcacacagaa caaggacggc gccgtcgact ccccggacgc caagaggacc
     8221 acgtgcgacc tcggcacgac gcgggtccgg ctccaggaaa ccggcggcag cgcaccggtc
     8281 atcctgctca aggccacgaa caccggcagt acccgctgcg acctgtacgg ccaccccttc
     8341 ctcggctacc cggacgccca gtccccggtc caggtcggcg gcggcccgcc ccaggccgtg
     8401 gtctccctgg agccgggcaa gtccgcctac gcctcgctca gcctggagaa gggcagcggc
     8461 aacaacatgc accgcgagaa ggagctgacc gtcgagctgg ccgacagcaa gcagcacggc
     8521 accggctcca ccgcctccct caccgccccc ggcgccggcc tcgccctcag cgacgcctcc
     8581 accgtctcgt actggaacac caccccggaa cagacgatgt gacagacccg agccgcgtcg
     8641 gagacctcat cacgcctcgc ccccggcttc ccgttcccga gcccaggggg cgcggttctc
     8701 ccctcggcga ggcggggcgc gtcgccacgt gccgcacccg gcacccgcac ccgcacccgc
     8761 acccgcaccc gcacccggcg agcatggcct caccggtttt cggagagcac ctcggccatc
     8821 cggtcgcagg cgtcgtcgag cagggccacg aggtccacct cccccatggg gccgctcatc
     8881 gcctcctcca gtcgggtgcg gagggcgacg agccgggcgt cgcaaggacc gtaccgctcc
     8941 agtagttcca gggtcctgcg agcgccgtcg gcgcagcggg ccggtccgta ggctgtcggt
     9001 tcttccagca ggccccgccc gctgctgagg aggaacgcgg cgaggagggc gatctgttca
     9061 gccagttccg tcggcagtgg acggctgctg gttccagaat tcatgcctga tcacctcgtg
     9121 tcgttcacag agctggtccg cgcgttgccg ggggtgggcg ggtctgccga tggcgacgag
     9181 caggaggggt tccaggtggg gaggcaggcg cagcagacga ctgatcgggg cggagcggta
     9241 gctactgacc gggcagcctc ccagtcctgc cgcgtgggcc gcgagcagca ggttctgcac
     9301 ggccatcgcg aggcacaaca tgccggtgtc gtagaaggat tcagcgtcgt ggatgacttt
     9361 gcggcggtcg aagcaggcga cgacggcgag cggcggcagg ccgagcattc cgggcgagaa
     9421 ggcgcgcagc cggcgtactt gtgcgggatc cctgaccgct acgaaagccc aggcccgttt
     9481 gttggcggcg gtaggtgcac tcaacatcgc gtcgaggaga cggtccaaca tcgcgtcgtc
     9541 caccggttct tcggtgtact gacggacggc cgttcggctc gtgagcacgt cgaggaaggc
     9601 ggagaagggt aacggggaat cgatggcggc ccgccccttc tccgatgtgg tggtggagag
     9661 cccagcagtc ggtggcccca tacgcctcac ctttcatcgc ggcctggaat tccttgcggg
     9721 acatggcatg gctcaccgtt ccctcctgac gagagggaaa cacgtcccgt acgagtgaat
     9781 gggccggccc tcacgccgcg cgcccctcgg tacgcccagc gcacttcccg gggcatcccg
     9841 taggacatgg catgcctccc gaccacctca aaggctggtt ttccgcagtc atgtccgctt
     9901 cttgaggggg accggcccca agcagggaag agagtgtccg gggcgcccta cggacttcgc
     9961 cgggaaaccg ccgccccagt gaagaaagga caactgggtc gtgaacgcag aacgggcgga
    10021 cgatgtcgtc gtctccccac gggcccgaat ctcagagttc accgaatgca ccgaaaccac
    10081 cgaaaccacc gagaccaccg gagccaccaa atccgccgaa tccgctaaat tcggcgaacc
    10141 cgccgaaccc gccgaacccg ccgaatccgc tgaaagcacc gagcggcgaa tcgggcagtg
    10201 cggattacta ccgtccgcca ccggtgcttt ccgctcgaat ccgctgaccg agcgatgtcg
    10261 aagtatcgag gcacgcgggg accacatcct catcggagtg agtaccggca acagctactt
    10321 cagcaccgac cggctgaccc agctactgcg ttggtcgcag aaacgcttcc gggtcgtcga
    10381 cgtcatctgc gcggacacct gtatcgacac catgctcatc gcggagggct gcgcggagtc
    10441 ggaggcgcgg cagcgggcca agcggcggat cacgaacgtg cgtcgccgga tccggcacgc
    10501 cgtgcgggac tctcgtcctg ggcatgcgtc gaccaccacg cacctgttgt ccgacttcga
    10561 gcggtcggac gcctacctcg cggtgcgcac acgggtcctg aacacgctgg aggaccaccc
    10621 gccgttcacc cgggcctgtc aggccatggt gcgctgcttc ctgcccgctg gagccgggga
    10681 cgacagcgac gacctgagcc cccggatgcg ggcgggcctg gcgtatgtcg tgaatgagct
    10741 gccgttcgtc atcgacacac ccggcatcct cggtccgccc acctcactgt cctgctacca
    10801 cgttctgcca cccgccgtac ggcatctgta cctggagtcc ggcggcctca caccggtgga
    10861 aggccaggga ttcgccgtca tcactcccgt gcctccggcc gggtccgagg aggaaggcag
    10921 cgcatgacag aggtgccgac gcccgtcgtg cccgacctgg atttcccgct ctcccgcagg
    10981 ggcgacaccg tccccgccga atgcgcgtgg ctgcgccgga agcggccggt ggcccgggtc
    11041 aggaccatga ccggcgacct cgcgtggctg gtctccacgc acgaactggc caccagggtc
    11101 cttcaggacg acaccttcag catgctgcgc gtgggcgagg ccggggcacc gagccagtac
    11161 gcgccgacgt tccccgtcga actgcgcaac agtatggccc gcttctccga cgacggcctg
    11221 cgcggcgcca tcatgaaagc ggtgtccccg ccggttgtcg ccgcctccgc ggacgggatg
    11281 cgtcggcgcg cggacgaact catcgacgcg ctggtggccg acggcccgcc gctggacttc
    11341 aagcagcact tcaccgaccc ctacaccgtc tccgtgatgt gcgcggtact cgggctgccc
    11401 gacaccgact ggcgctccat gctggcctgc ctggacatca ccatcatgac cgcccccgaa
    11461 ccgttcgagg gagcccgcgc caactgggac aagggcatcg cccggatgac cacccgcctg
    11521 cgcgaacccg gcgcggtccg ggcggccggc ctcctcggct cgctcgcccg gctgcgggag
    11581 gcggactccg cggaccctgt ccccgatgac gttctcgcga tggccctgca cacgctcttc
    11641 gaggccgggg cggccagtgc cgccacgttc ctgctgcacg cgacgctgct gctcatgtgc
    11701 caccccgagc aggcggacgc gcttcgcgat caccccgagc acctcggcac agcggttgag
    11761 gaactgctgc gccacaacct ctccatcggc gacgggctgc ccaggatcgc gaccagggac
    11821 atccggctgg gagacgcgga catcaaggag ggcgacctgg tcctcgtcct ggtcgagggt
    11881 gccaaccacg acccgaccgc cttcacctcc cccgaacgcc tcgacctgcg ccgcaccccc
    11941 aacccgcatc tctccttcgg cgcgggcagc cactactgcc ccgccaccac tctcgcgcgg
    12001 gcacatgccg acatcgcact cgaagcggtg ctgcgccgac tgcccgacct gaggctcgcc
    12061 atccccgtcg agcagctcaa ctggcgtacg ggctggatca aacgcacctg cgagcggctt
    12121 cccgtcctgt ggtgaacacg cgacgcccgc ccatccacct ccgcaaggaa ggcagccatg
    12181 tctcccactt ccgctgatcc tcccgccgcc gcgaccgtca ccccctccga ctccaccggc
    12241 ctgtgcgagg ccgcgcttga gcacggccgg atcgacggcg ggtatctggt cttcgacgac
    12301 ggcccgcccg ctctcggccg agcgttgcag gacggcatgt tcctcgtcga catcccggcc
    12361 gacgtagcgg tcgccactgg tgacgccttc gcggaacact tcttccgcgg gccgaccagt
    12421 ccgccgtacg gcgagttccg cgacatcacg agcgactcct tcggtgaccc tcttctgggc
    12481 tttcaccaac gggccaacaa atcggagcag ttcctgctcg aacgtcgctt ctgggacacc
    12541 cgcttccccg acgagatgac cgccctgggc gaggccatga cccggctgtc cagtcacatc
    12601 atggccggcg tcctggccta cagcggtatc ccctacgacc ggtgggggcg ggccaccgga
    12661 gactgcgtcc tgctgggcgg cacgtatcac ctcacgttca accactacct ccccacccac
    12721 ttggacctcg gactcaatcc ccaccaggac gacgggttcc tcaccatcct gcgcgcgacg
    12781 acacccggcc tggaaatcga tcgcggggag ggcacatggc agacggtgac gccgccgccc
    12841 ggctgcttcg tcgtcaactt cggcctggcc atggagatcc tgacgtcagc cacacgaacg
    12901 cccgcgaccg ccgtactgca ccgcgtcagc ggccaacgag gtgaccgctt cagcttcgcc
    12961 cacttcgcct ccgtcacaca aacccccggc gcggacagcg gcgtccaccg ctacctgccc
    13021 gcgaccggag cgcttgagcg cgtgtgcacc gcgcaggatc tgctgcacag cgactacgcc
    13081 gcctccgacg tggccaccgg aacctgaaca cctgcgccac cggaatccgt gcgcgccgcg
    13141 ccgctcggcc ggaatccgtg cgcgccacgc cgtgctgctc ggcgggtccc gcggcccccg
    13201 agtggtcgta cgtcacgact cctgcctcgg agtgaccggt accgccccca ccatcccgcc
    13261 tggaggtcca tgatgaccgt gtccaccgag atcgagttgc gtcctgtgcc ggggccacgc
    13321 ggcctgcccc tgctgggtaa tctgccggcc ttcggcaagg atccgctgtc cttcttctcc
    13381 tccctgcgcg acgagtacgg ggacgcggtg acgtggtccc tcggctcacg cccggcgctc
    13441 ttcgtggctc accccgcgca catcgcggaa ctcatggccg aggtggagca caccttcgaa
    13501 cccggcgatg tgggctggac gttcgcgaag gtgtgcgggg agagcatcct gcgcagtcga
    13561 ggggcacagt ggcggcgcaa acgcgcgatg gtccagccga ccgtgcgccc caagcaggtg
    13621 cgcgggtacg ccacgacgat ggtcgagtgc gcccagcaga ggggaaacgg ctggcgggag
    13681 gggggccgca tcgacgtggg gcgtgagatg gagcggatca cacagcggat cgtgtcgcgc
    13741 acactcttcg gcaacgacct gggggctcgg gccgatgtgc tcggcgagtc gctctccgcg
    13801 atcgaatggg agatgggcgc ggaggtccgt agtctgcgtc tgttccttcc cccctgggtc
    13861 ccctccgcgg cgcggcgacg cctcctcgcg gagctggcgg tggtcgacga ggaagtggga
    13921 cgtctggtcc gtacccgtcg gcaggccatg gaccgcgggg aggagcggga acgagaggat
    13981 ctgctcagcc gcctgctggc ggcccgggac ggccaggggc agcgtctgtc gtccaaggag
    14041 gtgcgcgacg aggcggtgac cttgtggatc gcgggaaacg gcacctcgac cacggccctg
    14101 acctggacgt ggtacctcct cgcccggaac ccgggcgcgc gtacgaaact cacggcggag
    14161 ctacagcgcg tactcggcga ccgctcgcct tccttcgagg actacgagtc tctgacctac
    14221 acacggcagg tgatcaagga gtcgctgcgc ctgtacccac ccgcctgggt gattcccctg
    14281 cgggccaaag ccggagcccg gttgggtggc cacgcgatcc gcgcgggtga cgcggtctgg
    14341 tgcagccagt gggtcaccca ccgcgatcca cgctggttca ccgacccgct ggccttccgc
    14401 cccgaacggt gggacggcga gtccacggcg aacacgtcct ggcagacctg gttccccttc
    14461 ggtacggggc cgcgtacctg cgtgggagcg cgattcgctc aggtggagac ggcactggta
    14521 ctggccacgc tcgcccggcg ctggcacctg gaggtggacc ccggcgaagt ggtgccgcag
    14581 gcggttcagc tcctccaacc gagcacgccc gtacgggcca ccgtccgtgc ggcggctcct
    14641 ccctcgactt gacgaccggc gaagaccgct gacggcaggg agggaggcga gcgcgcgagt
    14701 gcctcgggcc catgacggcg gacaccggcc cgtcaccggg gcgcagaccc atccgtgccg
    14761 cgcgtcgtcg cgggcccgtc gcgcatcgca catcgcgtcc accggctcga cggcgacgac
    14821 aaccacgggc gtcggccccg ctgtcgcggg gaacaggggc gtcgcggctc ccccaccacc
    14881 gacaacgagc tggagccacc cccgcagtcg cgcggggagc aggggacgtg accggtctcc
    14941 atcagccgcc gggcgggacc atccccgcag gcgcggggag caccgcgcgg gtggaggcga
    15001 cccacgcgtg atcgctggga ccatccccgc aggcgcgggg agcgctcttc gtgagccgcg
    15061 tttccatcga gcgatgccgc tcggtgcatc gaggtcgaga gaaagggccg tacggagtat
    15121 acggaagcgt gtttctccgg agaggcctgc gcggcaccgg ctacgcgtgc acaccggcgt
    15181 ttccggcctc agccgagcag gcccgcctgc tgcgccagta ccgccgcctg gacgcggttg
    15241 gtgcagtcgg tgcgggtgag gatgctgccg atgtgcgcct tgaccgtgcc ggagctcagg
    15301 tggagctgtg cggcgatccc ggcgttggag agacctgcgc ccatcagccg gaggacgttc
    15361 cgttccgccg gtgtcaggtt ctcgatcctg cgtgccgcgg cgtcgctgcc gtggcccgac
    15421 cggacccgga agtcgacgag ttggcgggtg acctgcgggg cgaggacggg ttcacccgcg
    15481 gcggcacggc gtacggcgtc gatgaggtcg cgaggaccgg tgtccttgag aaggtagccg
    15541 tgggctccgg cacgcagggc gcgggtcacg ctcggttcct cgccgaaggc cgtgagcatc
    15601 accacccggg tacggggcga gtgacgggcg atctcggcgg cgccggtgat gccgtcgccg
    15661 ggcatgcgga tgtcgaggag ggcgacatcg acgggatgga cgcggcaggc ttcgaccgcc
    15721 tcacgggcgt cctgtgcctc ggccacgatc cggacctcgt cgtcgttctc caggatcagc
    15781 cggatcccgg cgcgcatcag cgcctcgtcg tcggcgatca gtactcggat catcggttca
    15841 gtgtagaacc gccatgatca acaggacgag ggagccgccg acggtcggca gcagcaccag
    15901 catcgccgcg cagcccccac ccaggaggcg gggccatgtc aggacttccg tggaaagcgg
    15961 tggcctggag ccggccccgc cggacagcgg gggcccggaa cccgccccgc cggacagcgg
    16021 tggcctggag ccggccccgc cggacaccga cccggccgaa gtggcgtaca cgggcggcat
    16081 atcgggcatg gcgggtatac gggcggagag ggcgaagccg ccctcggggc gcggtcccgc
    16141 gtcgaggaca cctccgagca ggcggaccct ttcctggagt ccgacgagtc cgctgcggtt
    16201 cccgtccccg cgagaacacg gccccggcgg ggcatcgttg acgacggcga ccaccacggt
    16261 gtccccttcg tcgtggaacg tcacacggac cggcgcgccg gacgcgtgct tcagcgcgtt
    16321 ggcgagtcct tctcgggtga cacggtggac ggcctgccgg gtacgggcgt ccgcgtccat
    16381 cgccccggtc gcgttccagt gcagttcggc gtcggccccc gcgttccggg aatccgcgac
    16441 cagggccgag agatcctcgc gggtcccccg ctcgccggtc tcctcaccgg tctggtggcg
    16501 gaggacgccg aggatgccac gcagctcctc catggccgtt cccgcggtgg tgtgcaggaa
    16561 ttcggcgcgg gccgccagcg ggggcgcctg tcgctcgacg gcgagctgga gagccccggc
    16621 gtgcaccgag atgaggccga tacggtggcc gagcaggtcg tgcatctcgg cggcgatgcg
    16681 cgcccgttcc tccatgcggg ccgtctcctc agtgaggaag cgggcctgtt cgaggtaggc
    16741 gttgcgctcc cgcagcagcc cggtcagcgg gcggcgacgc cccagcatca ggccggacag
    16801 cgcgggcagc aggatgaaca gcgcgctcgc accggcgccg gcggccaggt acgacatctt
    16861 cgggagtccg ccgacggacg cggcggcgat cgatacgagc acggctccgg caccgctcgc
    16921 tccggccacc ccccaggcgc gccgtgcggg ggtgacgcgg cgcacggcgg accacacgac
    16981 gcacggcacc accaccgtcg cccatacgtt gtccccggcg accaccggca cacagcccat
    17041 caccgtgagg gccgggtaga cccgccgcgc gggcacgagc agcgccgccc acacccccag
    17101 gaggatcgtc gtcaccgggt gggccggcgg gatcagcggt agcggcgcca gcgtgcccag
    17161 cagaaccagg cccgcgagta cggactcgat gacgaccgtc cgccggggcg cggcacgcac
    17221 cgcgtcccga ttcgcggcgg cctcgcggcg tatccgcctc cacggtcgca ctgccgccgg
    17281 gcccctcatg gtttcctccg tgtgcgtgcc ggtctcgacg gttgtgccag cccgacgggt
    17341 gttctcgcct cgacgatcgt tctcgccccc gcacctgttc tcgtccgccc tcgtcatacg
    17401 cggcgggcgg gccgccgcgg tctcaggcgg cttgcgccgc tccgcccggg acctggagtt
    17461 ccggttccgc gcgcagcccg gcgacgtcca ccccgctctc ggtcagcacc cgctcgatct
    17521 ccgccgcgga ctccgcgtcc gtcccggtcc cgtccagcag ggcggccagc aggtgggtcg
    17581 tacccaccgt ggacgagccc tgagcggagg cggtgtactg ggtgacgtgc aggagccgct
    17641 gttcgaactc ggcggtgccg acgacctcta cgggtgcctc ctccgcgacc cccgtggagg
    17701 gaagcattac gcgggcgaca gcgtcctgtc gtgcgccgtg acggcgtagg agtcgcgccc
    17761 cttggttcgc tcccgtcagt ttctcgggca gctcgcgccc cgcgacggtc aatgaccggt
    17821 ccagcgtcag gatacccagc agcacatcga cgggtcgcgg ctccgacgcc ccgcgccgca
    17881 ccgcccctcg ccgcgcttcc gaacgcacca cggccaccac cgcggagccg aaccccgcgc
    17941 cgcccccgag aatccaggcg gtgaacttcc ggctcagcgg attaccgctc ttcccgaacg
    18001 tccccgcctt gcgaagcacc agcaccgctg ccggctccgg cacttcgtcg ctgccccgca
    18061 gcgcgtcgag tgcggccgag gccgcgccga tgtccagctt ctccaccacc atcgcctcgc
    18121 gggcccgcgt gtccggcgac tcgaccagtg cgcgggccac atggcggacg cgtaccgaaa
    18181 gggtgccctc gtcgcgtgcg gcctccagcg cctcgcgcag gcagacccgc aacgcaccag
    18241 tcatcggcgg gatcgcaacg ttttccggct cctggtcctg gacctggacc tggacctgga
    18301 cctggacctg gtccgacccc tgctcttccc cctgcttccg ctgctgcctc tgatcgttct
    18361 ggttccgctg atccttctgg ttcttctggt tctttcgatt cttccggcgc tgcctctggg
    18421 tctcctcgtg cctgacctcc cgccagaggg cgtcgatctc ccgctcgtcg tccgggtctc
    18481 ccgccgcacc gtcacccgcg tcggcgctga cccacacgga tgtcccccgg cacccgatag
    18541 aaccgccgag cgagccagag gccctcatcc ccggggcgat ggcggagccc gcggccgact
    18601 caccggacac gagcgcgctc agcacgctct ccgtaccgac gtcctcgcgt tgctgcttgg
    18661 cggccttact catcgcctcc cccaacagct cgacgacgtc cctctcgaac tgggtggtcg
    18721 cgccggcgtc gcggtctgac gttcgctgat ccatcggggc tccctctccg tggtgtcacc
    18781 tgctgagagg gacgctagcc gcgcgttcta cgaccccgcc tcggccgaac ggccatgctt
    18841 ccgatccgaa cggccatgct tccgatccga acggccgatg ccgtgccgcg atctgccatt
    18901 ggccacccag cgccgggagc gcgcggcgcc ccgctccgca ctcccgtgcc cccgtcggtc
    18961 gatcgccagc actcgtgcgg caggcgaacc ggtacagtgg acaaccggta caacgtcccg
    19021 gttcatcgta cgagaaaata cgggacgctg taccggttgt caatcacgcg agtgcaggag
    19081 gagacaccgt gagccacgac gaccgcagtc ccacgacggc gacccggccg aaacgggcgg
    19141 acgcgcggcg caacgaggtg gtcctgctcg atgccgccgg ggcggtcttc gtgaggtcgg
    19201 gggtcgaggc gccgatccgc gacatcgccg ccgaggcagg cgtagggacg gccacgatct
    19261 accgccactt cccgacccgg gccgacctca tcctcgccgt gtaccaccac caggtagagg
    19321 cgttggccga agcaggcgcc gccgcgctga cggaaagcac gcaccctcac gcgtcgctgg
    19381 ggcgatggtt cgagcagttc gtggacttcc tggtgaccaa gcacgggctg gccgcggtac
    19441 tgcagtccga cgacccgtgc tacgaccctc tgcactcgta cttcctcgaa cgcatcgtcc
    19501 ccgtctgcgc ccagctgctc gacgccgccg ccaccgcggg cgagatccac cccggccagg
    19561 acccctacga gctcatgcgc ggcgtcgcga gtctctgcgc cggcgtcggc accacccacc
    19621 agtaccagta caacgcacgt cggctgaccg gcatcctcat cgccggcctg caccgctccg
    19681 cctgagggtc ctcgcgatat gggcgcccga gccgcggggc tgatcggact cccctgccgc
    19741 aagggcccct gaggccgggc ggtgcggcgc agcgggagac cctcaccgag ttcggccacg
    19801 ccgtcaccca tctcggccac gaccccctcg gtcatggtgg gtccaggggc cacgctgttg
    19861 acgtcggccg tcctgcggcg ggccccgatc agaaccagtg caggcagtgc gggggggcgc
    19921 tcgggggcga agagtgtgtc cgcgcgggcg gcagcgcccg ggtggtgggc ccggatgtgt
    19981 ccggcgcgca cgagcgtgct cgggagggcg ccgccgagat agaccgcgct caggtcgcgc
    20041 acgtccagtg acagatcggg ccgctggtcc gtggggacgc agtcggcctt gccgtcgcgg
    20101 acggtcagca ggtagcggtc gtgctcgccc aggaagggat cgtcgacgtc caggacgagt
    20161 tcaccgtcgg tgaaccagcc gcgtgcggcc agagcacgcg ggacatcgag aaggcgcccc
    20221 cagagccagt cggcgtggcc gccgacctcg ccggcccggg ggtcggcgag ttgccagcgc
    20281 agcgggtgct cgggcgggac gtgcctgaac acgacgtgcg agaccaggtc gtgtccgagt
    20341 acgaaccggg ccagggcggt gaagaccgtg tcgtcgacgg cgatggtctc gtccaccgtc
    20401 agggtgttct gttcgccgat ggagtagctg gcgtacccgt ccgcggtgcc gtcggcgtcc
    20461 cggtggacgg cgacgtagcg cggcgccggg gagatcggcg gatgccccgc gcccagggcc
    20521 caccagcggt gcggccggga cagggcgccg ggctgggcgc ggcgataccg gtcgtagacc
    20581 gcttcgagga gttcgccgca ctcggcacgc cgcatcaact cgacagaacc gctgccggag
    20641 ccggtcaccg gcgggtcggc cgtcgcgaac gcccggggaa cggcgagggc ggccttgtgg
    20701 cgcggcaccg tcaaccgcgc ggtggaggtc gcgggtccgt agccgaacct gccgtagatc
    20761 ggggcctccg aggcgagcag cacggagagg aactcgcccc ggtcccgcac ctcggcgagc
    20821 tggtgccgca tcagcgcgct gagcacgcca cgtcgccggt gcgagggcag gacgccgacg
    20881 gcggtcaccc cggcgacggg gacgagtgcc ccaccgggca gggtgag
//
