LOCUS       NZ_CP045096            10216 bp    DNA     linear   CON 20-NOV-2024
DEFINITION  Streptomyces phaeolivaceus strain GY16 chromosome, complete genome.
ACCESSION   NZ_CP045096
VERSION     NZ_CP045096.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces phaeolivaceus
  ORGANISM  Streptomyces phaeolivaceus
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 10116136)
  AUTHORS   Mo,P.
  TITLE     Streptomyces sp. strain GY16 isolated from leaves of Broussonetia
            papyrifera
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 10116136)
  AUTHORS   Mo,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-OCT-2019) College of Life Science and Technology,
            Central South University of Forestry and Technology, No. 498,
            Shaoshan South Road, Changsha, Hunan 410004, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 15-AUG-2019
            Assembly Method                   :: HGAP v. v. 1.3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 120.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_009184865.1-RS_2024_11_18
            Annotation Date                   :: 11/18/2024 02:51:11
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,113
            CDSs (total)                      :: 9,024
            Genes (coding)                    :: 8,642
            CDSs (with protein)               :: 8,642
            Genes (RNA)                       :: 89
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 382
            CDSs (without protein)            :: 382
            Pseudo Genes (ambiguous residues) :: 0 of 382
            Pseudo Genes (frameshifted)       :: 112 of 382
            Pseudo Genes (incomplete)         :: 305 of 382
            Pseudo Genes (internal stop)      :: 23 of 382
            Pseudo Genes (multiple problems)  :: 53 of 382
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:44:39
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 9528221
            Orig. end                         :: 9538437
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP045096.1.
            Bacteria and source DNA available from Yunlin Zhao.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10216
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="32"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10216
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10216
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5216](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5216)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            complement(1830..3995)
                     /locus_tag="F9278_RS43385"
                     /old_locus_tag="F9278_43400"
     CDS             complement(1830..3995)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003995671.1"
                     /locus_tag="F9278_RS43385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F9278_43400"
                     /product="NHLP family bacteriocin export ABC transporter
                     peptidase/permease/ATPase subunit"
                     /protein_id="WP_152174498.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 3.9e-38, bitscore:
                     129.3, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPKARRRTVRTPTVLQMEAVECGAASLAMVLGHYGRHIPLEELRI
                     ACGVSRDGSRASNLLKAARSYGLTAKGMQMDVAALAEVKAPAVLFWEFNHYVVYDGMGR
                     RLGRRGVHINDPGKGRRFVPMEDFDASFTGVVLVMEPGDGFEKGGRRPGVLGAMPARMR
                     GTAGTLPAAVLASLLLVAVGAAVPALSRTYIDMFLIGGQTSLLGVLFTSMGACVLLTVL
                     LTWLQQANLLRGRLISSTLSSARFLRHLLRLPVTFFSQRSPADLVQRLQSNDAVAETLA
                     RDLAAAGVDAVVVVLYAVLLYTYDPQLTFVGIGVALLNVVAMRVVIRLRATRTAKLRAD
                     NARLTNTAYTGLQLIETMKATGGEEGYFRKWAGQHATTLEEQQRLGVPSAWLGVVAPTL
                     ATLNSALILWIGGMRAVEGHISVGLLVAFQALVTRFTAPITRLNGVAGRIQDFAADVAR
                     LKDVENFRADPLYARPDAGESTRRLQGHVELENITFGYSPLDKPLLTGFDLTVGPGQQV
                     ALVGGSGSGKSTVSRLISGLYSPWEGVIRIDGRRLEDIPRGALAASVSFVDQEVFLFEG
                     TVRDNVALWDPSISEEAVVEALRDAALYDMVTRRPGGINSRVEQDGRNFSGGQRQRLEI
                     ARALVRRPSILVLDEVTSALDAETELTVMDNLRKRGCACVVIAHRLSTVRDSDEIVVLQ
                     HGTIVERGRHEELVARGGAYAQLVRER"
     gene            complement(4064..4870)
                     /locus_tag="F9278_RS43390"
                     /old_locus_tag="F9278_43405"
     CDS             complement(4064..4870)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007386622.1"
                     /locus_tag="F9278_RS43390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F9278_43405"
                     /product="HlyD family efflux transporter periplasmic
                     adaptor subunit"
                     /protein_id="WP_152173221.1"
                     /transl_table=11
                     /translation="MQFRQQALAKLQSPEELDLPVRFARPQGWLVLSVTVVAMAAASVW
                     AVTGSVASTVSAPAVLTHGQGSYILQSPVAGQVTAVLAKQGERLPAEAPVLKVATTDGE
                     KVVRSVAAGRVSALAATIGQIIQTGANVAAVEKVADADDPLYATVYVPAENAASIPEDA
                     AVDLTVQSAPTQQYGVLRGHVQKVDRTAQTPQSIGAFLGDSQLGEQFTKKGRPVAVTVR
                     LDRKASTESGYRWSSQDGPPFELTSMTMATGSIRLADEHPIDWLLP"
     gene            complement(5001..5216)
                     /locus_tag="F9278_RS43395"
                     /old_locus_tag="F9278_43410"
     CDS             complement(5001..5216)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: strepbact"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020128984.1"
                     /locus_tag="F9278_RS43395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F9278_43410"
                     /product="type A2 lantipeptide"
                     /protein_id="WP_152173222.1"
                     /sec_met_domain="strepbact (E-value: 7.2e-34, bitscore:
                     115.2, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNSTPQVETAEISDAALDAVSGGLSVNAVGTVTGLVDGLAPVAGL
                     VNTVVGTVEGVTGLHTAPVTGLVTGL"
     misc_feature    5232..5245
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.24"
                     /tool="antismash"
     misc_feature    complement(5812..5824)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 19.2"
                     /tool="antismash"
     misc_feature    complement(5829..5840)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.29"
                     /tool="antismash"
     gene            5948..7375
                     /locus_tag="F9278_RS43400"
                     /old_locus_tag="F9278_43415"
     CDS             5948..7375
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003994899.1"
                     /locus_tag="F9278_RS43400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F9278_43415"
                     /product="S1 family peptidase"
                     /protein_id="WP_226967189.1"
                     /transl_table=11
                     /translation="MSHKRATKRKAFIAAGGVAAIGAAALILPNAMASQTESKDAAPKT
                     LAASDASDLASQLQELLGDAFAGAYYDSGEQQLVINVIDGLEIDGDDNNVIIQAQSAGA
                     EVREVDNSWSELQEGAATLKEQASVPGTAWAIDPRTNQLQVTADSTVTGENWDTIETAV
                     KSLGSGMATIKKSAGTFKTFLEGGDAIFGGGARCSAGFNVVNAEGAPAFLTAGHCGVAE
                     AEWSEEEGGAPIATVDAATATFPGAGDFALVNYNDPATQAASTVDLGNGQTVDINAAGE
                     AAVGLQVFRMGSTTGLADGQVTGLEATVNYPEGTVTGLIQTNVCAEPGDSGGSLFTEDG
                     QAIGLTSGGSGDCTVGGETFFQPVTTALAAVGATLGDAGAGAGEEAAGGAAAGAGEEAD
                     GGAAAGAGEEADGGAVAGAGEEEAAAAGAGEEEGAAAAGAGEEGDAGAVAGAGDAAGQE
                     QEQGIGDQGVDEQGVEQ"
     gene            complement(7581..9737)
                     /locus_tag="F9278_RS43405"
                     /old_locus_tag="F9278_43420"
     CDS             complement(7581..9737)
                     /GO_function="GO:0016791 - phosphatase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019057833.1"
                     /locus_tag="F9278_RS43405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F9278_43420"
                     /product="SpoIIE family protein phosphatase"
                     /protein_id="WP_152173223.1"
                     /transl_table=11
                     /translation="MAGAHASGGRTTVETARVGHPLLSLALAAMMDDVEAHSGAVYLLT
                     PDEPVLEMAVMAGLPRSFAAPWERVGLSAPVPVSEAVRGRRLVWVSGEEQMARRYPRIA
                     MVLPYPFALAALPVATRDTTYGAVFLTWPGSHPPELSERERDQLTSACDRLAKRLRRAE
                     EEGRPVLPEPDLSAPSATMVAGTLGTVEAARMVARLPYGMCALDLHGRITFANAATAEL
                     LGIPVSALLGTQLWASVPWLNDPAYEDRYRAALMSQHVTSFVALRPPSDWLSFRLYPGT
                     NGLSVRISRARAVAEAEHAARLEGEGPGRLVTINHVLALASALTEAVGVQDVVELVADE
                     IAPAIGSQALVMFGSRGGRLHVLGHRGYTDPHLVERFDGMPLSAPMPGAHALTTGVPAF
                     FESRQQLEHLYPMRQDTPDGLGAWAYLPLIASGRPVGTWVLGYADPHPFPADERAVLTS
                     LSGLIAQALERALLYDAKHRLAHGLQQALLPHSLPSIPGIEAASRYLPATRGMDIGGDF
                     FDLVLSHGRASAVIGDVQGHNVTAAGLMGQIRTAVRAYTTVGQPPEEVMSSTNRLLIDL
                     GSELFASCLYLRLDPEHGTAVMARAGHPPPLLRRPDGKVRVLDLAGGPLLGIDAAATYP
                     TTEVALAEGSVLVLYTDGLIEKPGVDIEDALADLGDRLSTAATGERSLDALADSLVREI
                     EAAEERADDVALLLLRATGTSPRP"
     misc_feature    9910..9925
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: medium, score: 24.94"
                     /tool="antismash"
ORIGIN
        1 cgaccttctg ctgcagttcc cggctgcgcg cgaactcgcc cgcccaggcg gcgtaggcgt
       61 agttctcggc ggcggccacc cgcagcttcg gcaggccccg cagggtctgg aaggcctggt
      121 tgttgagctt gttgctcagc acgaccaggc ggcgctgcca gcggacctgc cagagaccga
      181 ggcccaggaa caccgtggcc acgatcacca gcatgccgat cgccgccagg gccatgggca
      241 cgctgtacca gagcagcaga ccgaggttca ccgcgcccac ggtcaccgac tgggcgacca
      301 ccggaccgac cccggccagg gtgcggcgga tcgcgctgat gcccatcgcc gcgctcgcca
      361 gttcgccggt cgaacgggac gcgaagaagg cggtggggag gcgcaacaga cggtcccaga
      421 ccgccggttg gagggtcgcc tcgatacggc cctccaaccg gaggatcgtc aggttctgga
      481 ggaggaggaa cgcggccgag accacgctgg cgagcatgat cgccaggcag acccgcacga
      541 tcaggttctc ctgcgccttc ggcacgaact cgccgaggac cctgcccgtc gcgaggggca
      601 cgagcgagcc gagcaggacc gtcaccagac cgctgagcag cagccccgtc gtgtcgccgc
      661 gcgtgccgtg caggctgaac cgcatcagcc gcagtgggct caacacccgt tcgggcaacg
      721 gccggtagaa catcaccgcg cgcggctcga actccgccgc gttcgccttc tcgatcggtg
      781 tctcccggcc ggacgacggc tgtacggcca catagccgcc gcgccgccac agcagcgcca
      841 ccggcgcccc ggacagggcc cggtgcccga ccagcgggcc cacgttctcc cgccaccagc
      901 tcccgccgag gcgtacggca cggacccgca cccgggaggc gagcgcgatg cgctccaccg
      961 ggtcgaggcg gtcgctctcg gtgccgctct gcgcgggctc ggagagggtg atcccggccg
     1021 tccgggcgac gagcttgcag gccgcgtacg tggcgtccgc gtcggcggcc gtcgtccgcc
     1081 ggttcgcgga gggcttgccg atggacgcga gcagcgtgcg gtcggcctgg gcgcgcaccg
     1141 cctcaccggc cttgatcccg gcggccgtac ggtcctcgtg ggtgcgctcc agctgctcga
     1201 tccagcggtc cagcgtggcc agcagccgga actgctggtc gaccatgctc tgccagaccc
     1261 ccgggtccat cagcagatcg gccgccgcct ccgcgccgta cagcgagccg tactggacgc
     1321 tgccgggcgg cacccgcatc cagaacacgt cgtcgtcggt gggcgcggcg gcctgctcgg
     1381 tggccatcgg cgcctggaag aggatcgaca ggccccggcc gacgccgagg gcgagggcgt
     1441 attcgagggg gctggtctgc gggggtacga gctggggatt gccccattcg tcgtacgacc
     1501 aggtctcggt gttcacctgc tggtacagct cgcgcagccc gatgcgccgg accacgcagt
     1561 cgcggagcgg gcgggcgacc agggtgtgct ggggcccggc gaccgggccg agcagcagcg
     1621 cgcccgcctc cagacggccc agatggtgcc agtggccctg ctcgacggcg tcgaccgcga
     1681 acaggtccag ggcgccggag gccaccagcc acagcgtctg cgggccttcg aggtcgaggc
     1741 gggtgtggcc ggcgcggtcg aggggggtgc ccatggcgcc gagcgcgccg aggacgaggt
     1801 cgccgccctc ggatacggac gtcgtcatct cagcgctccc tgaccagctg ggcgtacgcg
     1861 ccgccgcgtg ccaccagctc ctcgtgccgt ccgcgttcca cgatcgtgcc gtgctgcagg
     1921 acgacgatct cgtcgctgtc gcggaccgtg gagagccggt gggcgatcac cacacacgcg
     1981 cagccgcgct tgcggaggtt gtccatgacg gtcagctcgg tctccgcgtc cagcgcgctg
     2041 gtcacctcgt cgaggaccag gatgctgggc ctgcggacca acgcccgcgc gatctccagg
     2101 cgttgccgct gaccgccgga gaagttccgg ccgtcctgct cgacccggct gttgatcccg
     2161 ccgggtcggc gcgtcaccat gtcgtacagg gccgcgtccc gcagcgcctc caccacggcc
     2221 tcctccgaga tcgacggatc ccacagggcc acgttgtcgc ggaccgtgcc ctcgaagagg
     2281 aacacctcct ggtcgacgaa ggagaccgag gcggcgagcg cgccccgggg gatgtcctcc
     2341 agccggcggc cgtcgatacg gatcacgccc tcccagggcg agtacaggcc cgagatcagc
     2401 ctggacaccg tcgacttgcc gctgcccgag ccgccgacca gcgccacctg ctgccccggg
     2461 ccgacggtga ggtcgaagcc ggtgagcagg ggcttgtcga gggggctgta gccgaaggtg
     2521 atgttctcca gctcgacatg gccctggagg cggcgggtgg actcaccggc gtccgggcgg
     2581 gcgtacagcg ggtccgcccg gaagttctcc acgtccttga gccgggccac gtcggccgcg
     2641 aagtcctgga tacggcccgc gaccccgttg aggcgggtga tcggtgcggt gaaccgggtg
     2701 accagcgcct ggaacgcgac cagcagaccg acggatatat ggccctcgac cgcgcgcatc
     2761 ccgccgatcc agaggatcag cgcgctgttg agcgtggcga gggtcggggc gacgaccccc
     2821 agccaggcgc tcggcacccc gagccgctgc tgctcctcca gcgtggtggc gtgctgcccg
     2881 gcccacttgc ggaagtagcc ctcctcgccg ccggtcgcct tcattgtctc gatcaactgg
     2941 aggccggtgt acgccgtgtt ggtgagccgg gcgttgtcgg cgcgcagctt cgccgtacgg
     3001 gtcgcgcgca gccggatcac cacccgcatc gccaccacgt tcagcagcgc caccccgatg
     3061 ccgacgaagg tgagctgcgg gtcgtacgtg tagaggagca cggcgtagag gacgaccacg
     3121 accgcgtcca cgccggccgc cgcgagatcg cgggccaggg tctcggcgac cgcgtcgttg
     3181 gactggagcc gctggaccag gtcggcgggg ctgcgctggg agaagaaggt gacgggcagg
     3241 cggagcagat ggcgcaggaa gcgggcgctg gagagagtgg aggagatcag gcgtccgcgc
     3301 agcagattcg cctgttgcag ccaggtcagc aggaccgtca gcaggacgca ggcgcccatc
     3361 gacgtgaaca gcacacccag cagggaggtc tggccgccga tcaggaacat gtcgatatag
     3421 gtgcggctca gcgcgggcac cgccgcgccg accgccacca gcagcagact ggcgaggacg
     3481 gcggcgggca gggtgcccgc ggtgccgcgc atccgggcgg gcatggcacc gaggacaccg
     3541 ggcctgcgcc cgcccttctc gaaaccgtcg ccgggctcca tgacgaggac gaccccggtg
     3601 aagctcgcgt cgaagtcctc catcggcacg aaccggcggc ccttgcccgg gtcgttgatg
     3661 tggacgccgc gccggccgag gcggcggccc atgccgtcgt agacgacgta gtggttgaac
     3721 tcccagaaca ggaccgccgg tgccttcacc tcggcgaggg cggccacgtc catctgcatg
     3781 cccttggcgg tgaggccgta actgcgggcc gccttcagca gattgctggc gcgcgagccg
     3841 tcccgggaga caccgcaggc gatccgcagc tcctccagcg ggatgtgccg cccgtagtgg
     3901 ccgaggacca tggcgaggga ggcggcgccg cactccacgg cctccatctg cagcacggtc
     3961 ggcgtacgga ccgtcctccg cctggccttg ggcaccgggc gcttctgcgg ggcggccttg
     4021 cgtctgccgc gtacgggcgg cgggacggtg tcctggggcg cggtcacggc agcagccaat
     4081 cgatcggatg ctcgtcggcc agccggatcg aacccgtggc catggtcatg gaggtcagct
     4141 cgaacggcgg cccgtcctgc gaggaccacc ggtagcccga ctcggtcgac gccttccggt
     4201 ccagccgtac ggtcacggcc accgggcggc ccttcttggt gaactgctcg cccagctggc
     4261 tgtccccgag gaacgcgccg atcgactgcg gggtctgcgc ggtgcggtcc accttctgca
     4321 catggccgcg cagcacgccg tactgctggg tgggcgccga ctgcacggtc aggtccacgg
     4381 cggcgtcctc ggggatcgag gccgcgttct cggcggggac gtacacggtg gcgtacagcg
     4441 ggtcgtcggc gtcggcgacc ttctcgactg cggcgacgtt cgcgccggtc tggatgatct
     4501 ggccgatcgt ggccgcgagc gcggagaccc ggccggccgc gacggacctt acgaccttct
     4561 cgccgtcggt ggtggcgacc ttcaggacgg gggcctcggc gggcagccgc tcgccctgtt
     4621 tcgcgagcac ggcggtgacc tggccggcca ccgggctctg cagtatgtaa ctgccctggc
     4681 cgtgggtgag gacggccggc gcgctgaccg tggacgcgac ggaaccggtg acggcccaca
     4741 cggacgcggc ggccatggcg accaccgtca ccgacagcac cagccagccc tgcgggcggg
     4801 cgaagcgcac cgggagatcg agttcctccg gtgactggag cttggcgagg gcctgttggc
     4861 ggaactgcac gggacttccc tcacctgcgc gacaggagac gacagaacac gggacgacga
     4921 gggcgcccag gactttcggg caccccgaga gtcccggaac ctgtcaggtg gttccgggac
     4981 tcagcggcgc tggggctcga tcagagaccg gtgaccaggc cggtgaccgg ggcggtgtgc
     5041 aggccggtga caccctcgac cgtgccgacg accgtgttga ccagaccggc gaccggggcg
     5101 aggccgtcca ccaggccggt gacggtgccg acggcgttga ccgagaggcc gccggagacg
     5161 gcgtcgaggg cggcgtccga gatctcggcg gtctcaacct ggggggtgga gttcatgatg
     5221 gaacttccct tcgcatagct attcataagg ggggagcggc ccccttctgg ggacagaacg
     5281 acggccgcgc acgtgggtac ccacttctcg atccggagag ctggctgccc ccgactccga
     5341 gagctcggcg gcccccgcgg tgcgatggat ataagcagat cgccgccgcg cacatccaat
     5401 caacatggcc tctcaccagc gcagttggtg accaagacgg ttcattggtg caggagtgcg
     5461 cacggcttgg gtccagcttc ttcacacgga tcgcggcatc gtcatacgcc cttcattgcc
     5521 agccggaaaa cgaactggac agtcctgcct caaaggcacg gcacacgatg cgggcctgtg
     5581 cagaactgcc accggccgtg actccgctga gcatgcggtg tggagattcc ctgaagccgg
     5641 tttcccgatc accggcatga acggaccgct gtcgggcggt cgcggaccgt gcccggcggg
     5701 gtgcgggccg gtggcgccca cagagggccc acagggagcc cacagggagc ccgcaggggc
     5761 gcgcgggcgg gaagtcgtga aatggcgggc gaacgacggg cgtagcgcgc tttgcgaaat
     5821 ggaagatcga aatctttttg cggagcgttg aacaccccac cggaaccatc cgtaccaact
     5881 ggcaaccagg cgcccccagt tcatccgccg gacggcggta cggaccccgt ccccaggagg
     5941 tcaagagttg agtcacaaac gagccaccaa gcgtaaggcg ttcatagccg caggcggcgt
     6001 ggcggcgatc ggtgcggcgg ccctcatcct gccgaacgcg atggcgtcgc agacggagtc
     6061 gaaggacgcg gccccgaaga cgctcgcggc gagtgacgcc tcggacctcg cctcccagct
     6121 ccaggagttg ctcggtgacg cgttcgcagg cgcgtactac gactcgggcg agcagcagct
     6181 cgtcatcaac gtcatcgacg gcctcgagat cgacggcgac gacaacaacg tgatcatcca
     6241 ggcccagtcg gccggtgcgg aggtccgtga ggtcgacaac agctggtccg agctccagga
     6301 gggcgcggcc acgctgaagg agcaggccag cgtccccggc acggcctggg cgatcgaccc
     6361 ccgcacgaac cagctccagg tcaccgccga ctccacggtc acgggcgaga actgggacac
     6421 catcgagacg gccgtcaagt cgctcggctc gggcatggcg accatcaaga agtccgccgg
     6481 cacgttcaag acgttcctgg agggcggcga cgccatcttc ggcggcggcg cgcgctgctc
     6541 ggccggcttc aacgtcgtca acgccgaggg cgccccggcc ttcctgaccg ccggtcactg
     6601 cggtgtcgcc gaggccgagt ggtccgagga ggagggcggc gcgccgatcg ccaccgtcga
     6661 cgcggccacc gccacgttcc ccggcgccgg tgacttcgcc ctggtcaact acaacgaccc
     6721 ggcgacccag gcggccagca cggtcgacct cggcaacggc cagacggtcg acatcaacgc
     6781 ggccggcgag gccgcggtcg gcctccaggt cttccgcatg ggcagcacca ccggtctcgc
     6841 cgacggtcag gtcaccggcc tcgaagccac ggtgaactac cccgagggca cggtcaccgg
     6901 cctcatccag accaacgtct gcgccgagcc cggcgacagc ggcggctcgc tgttcaccga
     6961 ggacggccag gccatcggtc tgacctccgg cggcagcggc gactgcacgg tcggcggcga
     7021 gaccttcttc cagccggtca ccaccgccct cgcggcggtc ggcgcgaccc tcggcgacgc
     7081 cggcgcgggc gccggtgaag aggccgccgg cggtgccgcc gccggtgcgg gtgaagaggc
     7141 cgacggtggc gccgccgccg gagccggcga ggaggccgac ggcggtgccg tggccggtgc
     7201 cggtgaggaa gaggccgccg cggcgggcgc gggcgaggaa gagggcgccg ctgccgccgg
     7261 agccggcgag gagggcgacg cgggtgccgt cgccggtgcc ggtgacgccg cgggccagga
     7321 gcaggagcag ggcatcggcg accagggtgt cgacgagcag ggcgtcgagc agtaggcgaa
     7381 cgccaccgag aacgtggacg acggcccagg gatcagcggc cactgaaccc cggccgtcgc
     7441 ctcacggccc acctgtcggc cccacctcag cggttccggc cgacaggtgg aacggtccgg
     7501 ccctccggcg ggagggtcgg accgcttcgc gtcgcgggcg ccgctccgca actccgaaaa
     7561 aggggcggag cctcgttctt tcaggggcgc ggggaagtgc ccgtcgcccg cagcaacagc
     7621 aacgccacgt cgtccgcccg ctcctccgcc gcctcgatct cccgcaccag actgtcggcc
     7681 agcgcgtcca gcgaccgctc acccgtcgcc gccgtcgaca gccggtcccc gagatccgcc
     7741 agcgcgtcct cgatgtcgac gcccggcttc tcgatcagcc cgtcggtgta cagcaccagc
     7801 acggacccct ccgccagcgc cacctcggtc gtcggatacg tcgccgccgc gtcgatgccg
     7861 agcagtggcc cacccgcgag atcgagcacc cgcaccttcc cgtccggccg gcgcagcaac
     7921 ggcggcggat gccccgcccg cgccatcacg gccgtcccgt gctccgggtc gagccgcaga
     7981 tacagacagc tggcgaacag ctccgacccc agatcgatca gcagccggtt ggtgctgctc
     8041 atcacctcct ccggcggctg cccgaccgtc gtgtacgcgc ggaccgccgt acggatctgc
     8101 cccatcaacc ccgccgccgt cacgttgtgc ccctgcacgt caccgatcac ggcggaggcc
     8161 cgcccgtgcg agaggaccag gtcgaagaag tcaccgccga tgtccatgcc ccgagtcgcg
     8221 ggcagatagc gggaggccgc ctcgatcccg gggatcgacg gcagcgagtg cggcagcagc
     8281 gcctgctgca gcccgtgcgc gagccggtgc ttggcgtcgt acagcagcgc ccgctccagc
     8341 gcctgggcga tcagaccgct caggctggtc agcaccgcgc gctcgtccgc cgggaacgga
     8401 tgcgggtccg cgtacccgag cacccaggtg cccaccggcc gccccgaagc gatcagcggg
     8461 agatacgccc aggcgcccag cccgtccggt gtgtcctgcc gcatcggata gaggtgctcc
     8521 agctgctgcc gggactcgaa gaacgcgggc accccggtgg tcagggcgtg cgcccccggc
     8581 atcggcgcgg agagcggcat cccgtcgaag cgttccacga gatgcggatc ggtgtagccg
     8641 cggtgcccga ggacatgcag ccgcccgccg cgcgagccga acatcacgag ggcctggctg
     8701 ccgatggccg gggcgatctc gtcggcgacc agctccacca cgtcctgcac cccgaccgcc
     8761 tcggtgagcg cgctcgccag cgccagcaca tggttgatcg tcaccagccg gcccggcccc
     8821 tcgccctcca ggcgtgccgc gtgctcggcc tcggcgaccg cgcgggcccg ggagatccgt
     8881 acgctcagcc cgttcgtccc cgggtacagc cggaacgaca gccagtcgct cggcggtcgc
     8941 agcgccacga acgacgtcac gtgctggctc atcagcgccg cccggtaccg gtcctcgtac
     9001 gcgggatcgt tgagccacgg caccgacgcc cacagctggg tgcccagcag ggcgctcacc
     9061 gggatcccga gcagctcggc cgtggccgcg ttggcgaagg tgatccgccc gtgcagatcg
     9121 agcgcgcaca tcccgtacgg cagccgcgcc accatccgcg ccgcctccac cgtgccgagc
     9181 gtgccggcca ccatggtcgc ggacggcgcc gacaggtccg gctccggcag caccggccgg
     9241 ccctcctcct ccgcgcgccg cagccgcttc gcgagccggt cgcaggccga ggtcagctgg
     9301 tcccgctcgc gctcgctcag ctccggcggg tgggagccgg gccaggtcag gaagacggca
     9361 ccgtaggtgg tgtcgcgggt cgccaccggc agcgcggcca gggcgaacgg atagggcagc
     9421 accatggcga tccggggata gcggcgggcc atctgctcct cgccgctgac ccacaccagc
     9481 cgccgccccc gcacggcctc ggagaccggg acgggcgcgc tcagccccac ccgctcccag
     9541 ggtgcggcga acgaccgggg cagccccgcc atgaccgcca tctccaggac cggttcgtcg
     9601 ggcgtgagca gatacaccgc gccggagtgg gcctcgacgt cgtccatcat cgcggccagc
     9661 gccagcgaca gcagcggatg gccgacgcgg gccgtctcga cggtcgtccg tcctccggac
     9721 gcgtgggcgc cggccatgcc gaccacctcc tcgcacctcg tacgaccgcg tgccggaccc
     9781 cagggtcaag gctcctcccc gggggccgcc cgcgcacggc gagcgccgtg ccgtggacga
     9841 accgctgtac ccgctctcgt ccccgtcatg ccccctcggt gatgcgcggc gccgcgcgcg
     9901 ggcgccgcct cgaccgcctg ttcgacggcc cggtggacgc gtaacgccca ggccgtgtac
     9961 gcggcgaccg cgcccggctc gggatcggtg gccagcaggg ggtgccgttc ggcgacgtac
    10021 gagttgagcg ggcggccctc gacgaagtcc atgaccagga agcggtggtc gccgagagtg
    10081 aagtggtcgc gcacctcggg caccaccccg agcccggcca gccgctccag ggcggccctc
    10141 tcccgctcca gccgggtgac cgcgtcggcc ccgtcggcgg ccagcccggc gtgcgggcgc
    10201 ccctccttga ggacga
//
