LOCUS       NZ_CP045096            22188 bp    DNA     linear   CON 20-NOV-2024
DEFINITION  Streptomyces phaeolivaceus strain GY16 chromosome, complete genome.
ACCESSION   NZ_CP045096
VERSION     NZ_CP045096.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces phaeolivaceus
  ORGANISM  Streptomyces phaeolivaceus
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 10116136)
  AUTHORS   Mo,P.
  TITLE     Streptomyces sp. strain GY16 isolated from leaves of Broussonetia
            papyrifera
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 10116136)
  AUTHORS   Mo,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-OCT-2019) College of Life Science and Technology,
            Central South University of Forestry and Technology, No. 498,
            Shaoshan South Road, Changsha, Hunan 410004, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 15-AUG-2019
            Assembly Method                   :: HGAP v. v. 1.3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 120.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_009184865.1-RS_2024_11_18
            Annotation Date                   :: 11/18/2024 02:51:11
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,113
            CDSs (total)                      :: 9,024
            Genes (coding)                    :: 8,642
            CDSs (with protein)               :: 8,642
            Genes (RNA)                       :: 89
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 382
            CDSs (without protein)            :: 382
            Pseudo Genes (ambiguous residues) :: 0 of 382
            Pseudo Genes (frameshifted)       :: 112 of 382
            Pseudo Genes (incomplete)         :: 305 of 382
            Pseudo Genes (internal stop)      :: 23 of 382
            Pseudo Genes (multiple problems)  :: 53 of 382
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:44:39
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 9094482
            Orig. end                         :: 9116670
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP045096.1.
            Bacteria and source DNA available from Yunlin Zhao.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22188
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="redox-cofactor"
                     /region_number="31"
                     /rules="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /tool="antismash"
     cand_cluster    1..22188
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(PF04055 and (TIGR04085 or SPASM))
                     and (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /kind="single"
                     /product="redox-cofactor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22188
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12188](-)"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12188)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
     misc_feature    complement(163..178)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.46"
                     /tool="antismash"
     gene            complement(2378..>2665)
                     /locus_tag="F9278_RS41455"
                     /old_locus_tag="F9278_41475"
                     /pseudo=""
     CDS             complement(2378..>2665)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009713464.1"
                     /locus_tag="F9278_RS41455"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="F9278_41475"
                     /product="MFS transporter"
                     /pseudo=""
                     /transl_table=11
                     /translation="DAGVASATVNTMQQVGGSIGTALLNTLATGAATDYLVGKDPRDPA
                     VQVQAGLDEAYATAYWWSAALFVVGLVISLVLYRRGAPQQDSEAAPAVHM"
     gene            complement(2922..3257)
                     /locus_tag="F9278_RS41460"
                     /old_locus_tag="F9278_41480"
     CDS             complement(2922..3257)
                     /EC_number="2.3.-.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012792.5"
                     /locus_tag="F9278_RS41460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F9278_41480"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_152174434.1"
                     /transl_table=11
                     /translation="MPTRPPTIRHARCGCSTNGLVVGHGAIFGPRSEREVTYVVGRPHW
                     GQGIASQALAQLIKLERTRPLHADAAADNAGSIRVLEKCGFMVTGLSRCFARARGQEID
                     LVHLTLS"
     gene            3275..4453
                     /locus_tag="F9278_RS41465"
                     /old_locus_tag="F9278_41485"
     CDS             3275..4453
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018854667.1"
                     /locus_tag="F9278_RS41465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F9278_41485"
                     /product="IS701 family transposase"
                     /protein_id="WP_152166950.1"
                     /transl_table=11
                     /translation="MTVEQVESWSEGVAGLHARFAHRFGRSEPRERALDYLNGLVAPLE
                     KKNGWTLSEQVGQLRPDGVQRLLNHSDWDENAVRDDVRDFVVETIGAKNAVLICDDTGF
                     LKKGTKSAGVQRQYTGTAGRTENCQIGTFLAYASARGRALIDRELYIPVSWTDDRERCR
                     AAGIDDEIPFATKNEHCKWMLQRAVDAGIPFAWVTADEAYGQVKHLRVWLEERRIAHVL
                     ATKVNDTVTTADGGDARVDQLVAALPRQAWKRVSGGQGAHGERIYDWARVAIRPYWENG
                     FGHWVLARRSISDPTEIAYYVCYGSVASRLKDLVKVAAARWAVEECFQTAKGECGLDHY
                     QVRLYRAWYRHITLAMAALAYLTAVRAAEAAKGAERTTSKTSYPSASRRSAD"
     gene            complement(4469..4783)
                     /locus_tag="F9278_RS46565"
     CDS             complement(4469..4783)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="F9278_RS46565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_193241864.1"
                     /transl_table=11
                     /translation="MKIYLRELQDSDLLVFWEQLTDPELQQMAAVTRKYHYDRGHFDQH
                     WAKVRSDPAVILRTVLANTATASAGCGLGVCSGSGGHGPGCVVGSVTSADDGRCCGGGA
                     "
     gene            complement(4887..5625)
                     /gene="istB"
                     /locus_tag="F9278_RS41475"
                     /old_locus_tag="F9278_41495"
                     /pseudo=""
     CDS             complement(4887..5625)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene="istB"
                     /gene_functions="other (smcogs) SMCOG1151: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007268926.1"
                     /locus_tag="F9278_RS41475"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="F9278_41495"
                     /product="IS21-like element helper ATPase IstB"
                     /pseudo=""
                     /transl_table=11
                     /translation="MEASCRALRLPTIRSQFADIATDAAKGQMTYRGFLAELLLAECDD
                     GARRRSERRIKAASFPREKSLRQFDFDADLNIDPAVIHTLASCELVKKGLPLCLIGDSG
                     TGKSHLLIALGTEAATVGYRVKYVLATKLVNELVKAADEKQLTKTTARYGRADLLAIDE
                     LGYMELDKHGAELLFQVLTERVEKNSVAIASNEGSEGGQERYRPPALRGHRRPSHLRRE
                     HHRDRHGLLPPRSDPGQGRAGC"
     misc_feature    complement(5098..5100)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            5676..6173
                     /locus_tag="F9278_RS41480"
                     /old_locus_tag="F9278_41500"
     CDS             5676..6173
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="F9278_RS41480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="F9278_41500"
                     /product="hypothetical protein"
                     /protein_id="WP_226967159.1"
                     /transl_table=11
                     /translation="MLSLVSRDGDARRNREAMRAVLEVRTVDGLDLWPVAEVEPFSFLP
                     LSGELSSAEVGTVVMRIADHNNVDSDGEQAPQPANALGSFSHGLLRLEDDIVAPGGLGV
                     IDTSTSVTFLPGCCDGLESRRDWHRFVDDGNLLGFGHDPVSPVAERFGDIVRHRLDIRA
                     RA"
     gene            complement(6139..7005)
                     /locus_tag="F9278_RS47805"
                     /old_locus_tag="F9278_41505"
     CDS             complement(6139..7005)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1213: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="F9278_RS47805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="F9278_41505"
                     /product="hypothetical protein"
                     /protein_id="WP_226967160.1"
                     /transl_table=11
                     /translation="MPPMSKVDLHAALRRDSRAGLSNRALHHKYGVGFRTVRKTRLDPY
                     KGLVDQMLRADPTAPRKQQHTAKRVFDRLVAEYGAVDLAYGLVRAYVAERRDEIRIAAG
                     RGIAKAFVPQSHRPGAEAEVGFGDVTIRLAGQQVKCSLFSFRLSYSGKAVHRVSASGGQ
                     EAFFEGHVHAFSVLAGVPTGRVRCDNLNSAVAQVLGFDRARVETERWTAFRVGVHIEVP
                     GQVRANVVTTSRTMALPGPTLAAGRAEPIALWLRSHGRIGQVENTGESSCDGSAVVRHV
                     LGCPVGA"
     misc_feature    complement(7141..7156)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.32"
                     /tool="antismash"
     misc_feature    complement(7378..7393)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.11"
                     /tool="antismash"
     gene            complement(7384..7983)
                     /locus_tag="F9278_RS41495"
                     /old_locus_tag="F9278_41510"
     CDS             complement(7384..7983)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007388022.1"
                     /locus_tag="F9278_RS41495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F9278_41510"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_152172913.1"
                     /transl_table=11
                     /translation="MATGHTDPKRRERIIAATLDLIAEEGIAQVSHRKIAARAGVPLGS
                     MTYHFSGIDQLLQDAFSRFADHIVAVFDAHLAAAADRDQARVAVADLVHALSEGSRRDL
                     VLTQELYTLAARQPIYRHLTHEWMRRSRVHLEKHFDPDTARQLDALIEGLTLHRALATE
                     PHPYDLTLEAISRITATRPAMGASRSPTGTGRAASQ"
     gene            complement(7994..8575)
                     /locus_tag="F9278_RS41500"
                     /old_locus_tag="F9278_41515"
     CDS             complement(7994..8575)
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0016407 - acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Mac"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1156: Chloramphenicol acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014154813.1"
                     /locus_tag="F9278_RS41500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F9278_41515"
                     /product="sugar O-acetyltransferase"
                     /protein_id="WP_152172914.1"
                     /sec_met_domain="Mac (E-value: 3.3e-11, bitscore: 42.2,
                     seeds: 568, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEEYFALDPRTNLERMLAGDLYIADDPEIARKLRRAGMLAARYQ
                     AAYIEDPAAAQAILSELLGSVGDGTHVRPPLFVDYGSNITIGARTFVNYNLTALDVAAI
                     TIGDDCQIGPGVQLLTPTHPVAPQPRRDKLEAAKPITIGNNVWLGGGAVVLPGVTIGDN
                     SVIGAGAVVTRDVPADVVAVGNPARPVRNL"
     gene            complement(8660..9868)
                     /locus_tag="F9278_RS41505"
                     /old_locus_tag="F9278_41520"
     CDS             complement(8660..9868)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1106: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003969246.1"
                     /locus_tag="F9278_RS41505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F9278_41520"
                     /product="MFS transporter"
                     /protein_id="WP_152172915.1"
                     /transl_table=11
                     /translation="MTVDTLRGPAQAARQARVAVAVLFFTNGALLANLLPRYPQIKEDL
                     GIGNAAYGLAVVAFPAGAIAAGMAASILIRRMGSARVAVIGTTLTGMGILAAGMADSVM
                     VFAGALLLAGATDAITDVAQNAQGLRVQRRYGRSIINSFHAVWSIGAVVGGSMGAGAIA
                     LGLSRGQHLLISATLCATVACVALRFCLPGPETEPAADPDAEARPPQRTRRAATGTHPR
                     LVLAALVLIAVAGTLVEEAGSSWAAVYLADSLRTTAAQAAWGYIALVGAQFVGRLIGDR
                     LVDRFGQRSVARVGGFVAAAGMGLALAVPTVPGTVLGFAAAGFGVATLVPATLQAADEL
                     PGLKPGSGLTIISWLMRLGFLFSPPVVGLVADAAGLRTGLLVIPLAGLLVMLLAGVLQT
                     RRA"
     gene            complement(10001..11125)
                     /gene="pqqE"
                     /locus_tag="F9278_RS41510"
                     /old_locus_tag="F9278_41525"
     CDS             complement(10001..11125)
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_process="GO:0018149 - peptide cross-linking [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: SPASM"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016433951.1"
                     /locus_tag="F9278_RS41510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F9278_41525"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqE"
                     /protein_id="WP_152172916.1"
                     /sec_met_domain="PF04055 (E-value: 1e-21, bitscore: 77.0,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 2.1e-05, bitscore: 24.0,
                     seeds: 166, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 3.9e-07, bitscore:
                     29.4, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVPAPPWALLSELTHACPLRCGYCSNPLELTRRSQELGTSQWAD
                     VFRQAAELGVLHTHLSGGEPLLRRDLEEITRSAVDAGLYTQLVTSGDGLSAERIDSLVD
                     AGLHSVQLSVQHADPGRSDEIAGRRSFDAKLAAARLVKERCLPLGVNVVLHRHNLDAVA
                     DLIALAVDWRADRVELANTQFYGWGLLNRAALMPSREQLRAAGEVVERERKRLDGTLDI
                     TWVVPDYFSGTPKPCMGGWGAVSLTVTPDGTALPCPAAASLPGLDPPNVADRSLRWIWE
                     ESPAFNAYRGTDWMPSPCRSCERRTEDFGGCRCQAHALTGDATRTDPACSLSPDHAALV
                     ALTEADVAPRLVPRRPTVKRASPHRTASARRGSR"
     gene            complement(11122..11415)
                     /gene="pqqD"
                     /locus_tag="F9278_RS41515"
                     /old_locus_tag="F9278_41530"
     CDS             complement(11122..11415)
                     /GO_function="GO:0048038 - quinone binding [Evidence IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003962382.1"
                     /locus_tag="F9278_RS41515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F9278_41530"
                     /product="pyrroloquinoline quinone biosynthesis peptide
                     chaperone PqqD"
                     /protein_id="WP_152172917.1"
                     /sec_met_domain="PqqD_RRE (E-value: 1.6e-12, bitscore:
                     46.0, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 5.1e-09, bitscore: 35.3,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGEPQLWRPRVLPAAVLRHDRVRGADVLLLPERVVVLHGSGRAVL
                     ELCDGSRTVDEIAARLSAGADTDIGAGAGGESRVRHEVTSFLHRLRTEGCLR"
     aSDomain        complement(11140..11379)
                     /aSDomain="PqqD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing protein in a pyrroloquinoline
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_F9278_RS41515_PqqD_RRE.1"
                     /evalue="5.00E-15"
                     /identifier="RREFam006.1"
                     /label="F9278_RS41515"
                     /locus_tag="F9278_RS41515"
                     /protein_end="92"
                     /protein_start="12"
                     /score="46.0"
                     /tool="antismash"
                     /translation="PAAVLRHDRVRGADVLLLPERVVVLHGSGRAVLELCDGSRTVDEI
                     AARLSAGADTDIGAGAGGESRVRHEVTSFLHRLRT"
     gene            complement(11415..12188)
                     /gene="pqqC"
                     /locus_tag="F9278_RS41520"
                     /old_locus_tag="F9278_41535"
     CDS             complement(11415..12188)
                     /EC_number="1.3.3.11"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR02111"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016433953.1"
                     /locus_tag="F9278_RS41520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F9278_41535"
                     /product="pyrroloquinoline-quinone synthase PqqC"
                     /protein_id="WP_152172918.1"
                     /sec_met_domain="TIGR02111 (E-value: 1.4e-83, bitscore:
                     278.9, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTTGFETALATRPEPGGADPGSPGLGAWDEEQLEARLRELATAR
                     YHDRHPFNRRMHQGELSPAELRLWVANRFYYQCNIPIKDAHILAKLHLPAQRRSWLRRI
                     QDHDGLTDQDGGLEKWLRLGEAVGLARHELLTHRHLLPGVRLAVDGYVNFCRNNDRLEA
                     VASSLTELCAPSIMLTRLETFPLHYPWIDSAGLSYFRGRVPQGRRDGSEALAWVKEWAV
                     SRDQQDRALAALSFKCDVLWSLLDSVQGAERRETP"
     gene            complement(12185..13084)
                     /gene="pqqB"
                     /locus_tag="F9278_RS41525"
                     /old_locus_tag="F9278_41540"
     CDS             complement(12185..13084)
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014669247.1"
                     /locus_tag="F9278_RS41525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F9278_41540"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqB"
                     /protein_id="WP_152172919.1"
                     /transl_table=11
                     /translation="MLLRVLGTAAGGGLPQWNCACPGCAGARRHPSRRRLHDGLAVHAA
                     DPGAWFLANATPDVAEQLEGHPSLRPGAGQERTPVIRVVLTDAELDHTLGLLRLREAAR
                     IDVWCTEPVHKALTARLPLTDILSPYTTLTWHELPLTGVGEPAEIAGLRVSALPLSDKR
                     PRYAADEPAHPAWSTALNVHDPETGRSALYAPALAAWSDALGDEIAGTDCVLLDGTFLD
                     EDEPRRLGISRRTASGMGHLPIEGPEGTAGRLSRVGARVYYTHLNNTNPLVDPGDPAHE
                     RLAGLGLRVAEDRMVVSL"
     gene            complement(13094..13231)
                     /gene="pqqA"
                     /locus_tag="F9278_RS41530"
                     /old_locus_tag="F9278_41545"
     CDS             complement(13094..13231)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014174696.1"
                     /locus_tag="F9278_RS41530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F9278_41545"
                     /product="pyrroloquinoline quinone precursor peptide PqqA"
                     /protein_id="WP_152172920.1"
                     /transl_table=11
                     /translation="MHNEPQPQLHHQPQPSGQPSADWQTPDFTVVDTALEVTAYSLREK
                     "
     gene            complement(13360..14352)
                     /locus_tag="F9278_RS41535"
                     /old_locus_tag="F9278_41550"
     CDS             complement(13360..14352)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF018038.5"
                     /locus_tag="F9278_RS41535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F9278_41550"
                     /product="ThuA domain-containing protein"
                     /protein_id="WP_152172921.1"
                     /transl_table=11
                     /translation="MTTTARPRRRIRPLTAALTSVAGTLGITVALVATGTLSVAQGGGD
                     RGARQLGDPDYGVCRGVDVRCYHDWGNFDTSKGFKVLLYTRTAGPRHANLGPALGTGLN
                     PPVSDANVVQKALLRMGSDNGFQVDYTEDVTQLASAAALFKYNAVIFFSTSRDTLDDAA
                     QTSLRQYIRGGGGFVGVHNAFGTEYNWPWYEGLLGNANFYDHGPAQPGTVRTVNSKDAS
                     TKSLPRRWEFSDEWYNLVPAPTRVRVLAEVDETTLARGVKGNYHHPGHGDDHAVAWCQY
                     YDGGRAWLTTLGHDAKAFSTDGSFPGAAEFQKLILGGIESAMGKKPFCT"
     gene            complement(14408..16516)
                     /locus_tag="F9278_RS41540"
                     /old_locus_tag="F9278_41555"
     CDS             complement(14408..16516)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024753.5"
                     /locus_tag="F9278_RS41540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F9278_41555"
                     /product="PQQ-binding-like beta-propeller repeat protein"
                     /protein_id="WP_152172922.1"
                     /transl_table=11
                     /translation="MDRRSFLTSTAAGTATTVALLNNGTAEAAAPDKLGRPVPTQSHAA
                     TGRNFPKAGGNLGNQNHSSLKKINAGNVGKLGGAWHVNLEGGSTSNHQQCAVIAQDGVL
                     YLATTQQNVFAVDGRTGDVKWKTKVGTRTTNMRGLALGKGLAFTISGDNKVHALDQKTG
                     AVVWSRELMTEDGSGRGSLAGAAVYWDGLVYIGTQGSTGGARGRAYALDASTGEVAWVF
                     WGAPGPGEYGHDTWEGDTWKTGGAVCWIHPAVDPELGIVYWTFGNPYPRTDGSTRGGDN
                     LFANSLVAIDAKTGERRWHFQSVHHDIWDYDGVMSPVLADILIKGKKHRVVVYGSKTGM
                     YYILDRATGEPVHGMEERPVPQHKAQKTSPTQPFPGGEPFVDTAPRFDKATRPVPFYPT
                     GGLFEVHWDRATILFPGAGGAADWSFPSFSHRTGLVYVGYGLINSAYSNTHGGRVNTAR
                     PLGEYFAGGLVAVDPRTNTVAWRQEGDWSLAHGNSILSTAGGVLFQGRPDGVLTALDDR
                     DGSELWTWQCGAGVHTSPLTYEIDGEQYVAVLAGGNGLPYPDIPKGDHLWAFKIGGSVE
                     PAAAPTPPSRRNQIRTAAVTGETAQNTITLGRVWDSAKNAPGTTENLVVQNAMSPQHLS
                     IAKGTAVTFVNPADNRSAHGAVAFFDAEFDTGLLMPGQSYTYTFDTPGEYFYNDPAAPQ
                     STGKVVVK"
     misc_feature    complement(16415..16417)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(16732..17544)
                     /locus_tag="F9278_RS41545"
                     /old_locus_tag="F9278_41560"
     CDS             complement(16732..17544)
                     /EC_number="4.1.3.34"
                     /GO_function="GO:0046912 - acyltransferase activity, acyl
                     groups converted into alkyl on transfer [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019432098.1"
                     /locus_tag="F9278_RS41545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F9278_41560"
                     /product="citryl-CoA lyase"
                     /protein_id="WP_152172923.1"
                     /transl_table=11
                     /translation="MTSSPDEAALWWATAVSHIEPGSIELRDRPVQDLIGRASLVDVIW
                     LMLRGTTPSPPESALLEAALVAGVDHGPQAPSIAAARMAATCGIGLNNAVATGVNMLGD
                     AHGGAGQQCVEMLTDIRTLHTSGLGWDDAAHEVMAAWQSRSRYLPGFGHRFHPVDPRSG
                     PLLGLVRQAVADGVVGGDFLDGALAVEEALRRRRAGARPVPMNIDGATAVIYAELGFAA
                     PLARGLFVLSRSVGILAHAWEESGQGRRNKGPLPRNVLPARLPQPKDP"
     gene            complement(17541..18758)
                     /locus_tag="F9278_RS41550"
                     /old_locus_tag="F9278_41565"
     CDS             complement(17541..18758)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1189: L-carnitine dehydratase/bile acid-inducible"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014060205.1"
                     /locus_tag="F9278_RS41550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F9278_41565"
                     /product="CaiB/BaiF CoA-transferase family protein"
                     /protein_id="WP_152172924.1"
                     /transl_table=11
                     /translation="MHVRPLDGVRVLDLTNVLAGPYCSYQLMLMGAEVVKIERPGQGDL
                     ARSLGPDPSLNRDGVGASFLAQNAGKKSLELDLKDTADRALFEELLTGTDVLLENFRAG
                     VLERMGYGAERLAQLNERLVYCSISGFGHTGPLSDAPAYDQIVQGLTGMMSVTGTEDTA
                     PQRIGFPVCDTTGGLMAAFAISAALLRRERTGAGSRLDVSMLEASLSAMGWAVSNYLVS
                     GVPPQPLGDQNPTAAPSGTFHALDGPLNIAANQQQQFETLCRLAGVPELITDVRFSERE
                     GRKSHRAELNTALNRALAARPAADWERELNAAGVPAARVLTVPEALEQPQLAYRGFVTE
                     LSHPGRAGQPLRVVGSGVLVDGESFGPPAPPPLLGQHNTEGRKLARRWSTPVAGATASA
                     GEAAAS"
     gene            complement(18811..19581)
                     /locus_tag="F9278_RS41555"
                     /old_locus_tag="F9278_41570"
     CDS             complement(18811..19581)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1195: IclR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007379820.1"
                     /locus_tag="F9278_RS41555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F9278_41570"
                     /product="IclR family transcriptional regulator"
                     /protein_id="WP_152172925.1"
                     /transl_table=11
                     /translation="MDAEQGPGGGVRSVRRALDILSLLTEDQPTVPLKNMVDATGLPKT
                     TVVRLVQTLEQYGLLWATPGGYAAGPGLWRWAHLAHTSWELPPDTQKLLRELVERRGET
                     ANLMIRRDIHRVCVAQQESPQPLRHVVRVGDELPLWAGASSKVLLIGATDGLLQRIAAD
                     SPHGVPHVEQLRLWAQESATHGYAVSHGERDVGLTAVAVPIRSQSGVVVASLSLSGPSA
                     RIPAGATEDFAGDLLETAARIASQGFQHPLGPRT"
     gene            19795..21297
                     /locus_tag="F9278_RS41560"
                     /old_locus_tag="F9278_41575"
     CDS             19795..21297
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017: aldehyde dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012398.5"
                     /locus_tag="F9278_RS41560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F9278_41575"
                     /product="aldehyde dehydrogenase family protein"
                     /protein_id="WP_193241866.1"
                     /sec_met_domain="Aldedh (E-value: 4.4e-130, bitscore:
                     433.3, seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLQDLLKAADQNEVVEALPYLSGSWGGEGPPLERTGPYLRRTVSR
                     VPTATAGDIDTAVTLAGRYARQMADLAPAARADILEAAARGATAQRDRLARLLALELGK
                     PLKDSRTEIDRVASTFAVCAAEARRVDGENLPVAGWNTGIGNTALTYRAPAGVALAITP
                     FNAPANLLAHKLGASFAAGNTTLVKAPPQAPATSAAVVALLLDSGMPHQAVQLLHGGGE
                     VGAALCGADAVSVISFTGSAETGAAVARAAGAKRLALELGGNAATVVCEDADTAAAAKV
                     CARTGYSNSGQSCISVQRVYVHRGRYEEFLDAFTAAVDDLVIGDPLLETTDIGSMVDEN
                     AAERVVAWSEEARRLGARVIRGGTRDGATAAPTIVADPPPHASVVVHEVFGALVSVLPY
                     DDFDTVIEQCNTSRYGLQAGLFTHDITRILTAWRRLEVGGLIVNGSSNFRLDHVPFGGV
                     KDSGFGREAPRWLIDDYTVVKTLMLRGLSVWGDSRELPKENP"
     misc_feature    21349..21364
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 19.98"
                     /tool="antismash"
     misc_feature    complement(21985..21999)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.8"
                     /tool="antismash"
ORIGIN
        1 tctcggagtc ccatggcacc cacgtcgccg gaatcgtcgc ggggaacggg ctgttcggcg
       61 gcgagatgga cggcgcggcc cccggtgcga agatcgtgtc gtcccgcgcc tgcgcgttcg
      121 ggcccaccag ctgcaccaac atcgccctca ccgagggcat gatcgacctc gtggtcaacc
      181 gcggcgtcga catcgtcaac atgtccatcg gtgggctgcc ggcgctgaac gacggcaacg
      241 acgccacctc cgagctgtac acgcggctca tcgacaccta cggtgtccag ctcgtcatct
      301 cggccggcaa ctccggcccc ggcgcgaaca ccatcgagaa tccgggcctg gccgacaagg
      361 tgatctccgt cggcgcggga gtctccaggg agacctgggc cgccaactac ggctccgagg
      421 tggccgacga gtacgggctg ttcaccttct cctcgcgcgg tccgcgcgag gacggagggt
      481 tcacgccgac actggtcgca cccggctcgg cggtctccac catcccgtcc tggatgcccg
      541 gcagccagtt ctacgaggag tacgcgggct ggaacctgcc cgccggctac gccatgtacc
      601 agggcacgtc gatggcctcc ccccaggccg cgggtgcgag cgcgctgctg ctgtccgccg
      661 cgaagcagca gggcgccgac ctcagcccgg tgcagctgcg caccgcactc acctccaccg
      721 ccgtccacat caagggagtt caggcatacg aggaaggcgc gggccgtatc gacatccccg
      781 ccgcgtggaa ggcggtcgag aagggcgcga gtgcccacga ctacaccgtc cgggcgccgg
      841 tggacaccgt cctggaccag cagctggaga tgccgggctt cggtacgggc gtctacgacc
      901 gcgagggcgg gctgaaggcc ggccagaaga agacgtacga cgtcaccgtc acccgcacct
      961 ccggccccga cggccccgtc cgccacgaac tgcggctgga gaacaaccag gccgacacct
     1021 tcgcgatcct cggctccccg acggccgaac tgccgctgaa cgagccggtg accgtccaga
     1081 tccaggccgc gcccgcctcc gcgggcatca agagcgcccg cctcgaagtc gacgacccgg
     1141 ccaccgaggg cgtcgaccgg cagatcctga cgaccgtcgt ggtctccacc ccggccgagt
     1201 acacctactc cgtcccgggc tcggtacagc gcaacagcgc gaacagctac ttcgtgaccg
     1261 tcccggaagg cgccaggaca ctggaggtca ggctcggcgg cctgaaggac ggcagctgga
     1321 cgaccgccga cgcactccag ccgtccgggc tccccgccga tgacgacgac cccacgacgt
     1381 cggacgtcgc cacgtacccg aacccgcagg ccggagtctg ggaaatcgtg gtcgagtcgt
     1441 actacgccac ggagccgctc gacaatccgt acaccctcga cgtcgccgtc tacggcgcgt
     1501 ccttcgaccc ggaccccgtg accgtgccgg aggccgaggc gggcaccccg gccgccgtct
     1561 cctggaccgc gacgaacgga tacgcggccg tggacgggac gctcaaggga ggcacactcg
     1621 gttcctcgaa gaccgcccgc ccgaccattg ccgacggtgc gacacagacc accacggtcg
     1681 aggtccccga gggcgccaca tcgctggacg tggccatcgg ctcgcccgcg gacaacgccg
     1741 ccgacctgga tctcatggtg tacgacgcca agggggacct ggtcggctcg gacgcggacg
     1801 ccgatgccga ggaatccgtc tccgtcgccg acccggccgc cggtacgtac acgatcgagg
     1861 tgctggccta cgacgtgccg tccggttcga ccgccttcga ctaccgcgat gtcttcttct
     1921 cgaccgcgct cggctcggtc acgccggacg gctcggggtc ggtgaggctc ggcacgggcg
     1981 ccgcgacgac cgtgtccgca cacgtcacag ccacggcgac cgtaccggag ggccgcgacc
     2041 tgttcggcga ggtacacctc gtgaacgacc gcgggacggc cgtgggcgag ggcaccgtga
     2101 ccatcggaaa ggtcacgcag taaccgcagg cccgggccac cgccatctgc ccatgcggtg
     2161 gtggcccggg caggacctga tcccggtggc ccacgtgacg gcgggccgac agccgtgtct
     2221 ccggccggac tcgggtgcgc cgcgactccg ggtctcaacg gtccgcgagc ccgaggcgcc
     2281 gctcgcgggt cgaggcaagc cgaacggccc gccggaagtc cggcgggccg tagtcggagc
     2341 aggggatcct cgtgaatcgg gccgtgaggc agtgatgtca catgtggacc gcgggagcgg
     2401 cctcggagtc ctgctgcggt gcgccgcgcc ggtagaggac caggctgatg accaggccga
     2461 cgacgaagag ggcggcggac caccagtagg cggtggcgta ggcctcgtcg aggccggcct
     2521 ggacctggac ggccgggtcc ctggggtcct tgccgacgag gtagtcggtg gcggcgccgg
     2581 tggcgagggt gttgagcagg gccgtaccga tcgagccgcc gacctgctgc atggtgttga
     2641 cggtggcgga ggcgacgccg gcgtctgccg gtcaccgtcg gagaagccca ggtcctgctg
     2701 ggccgagggg agtgcgatgt tcacgatggt gccgtccagc accaccatga gctgggccag
     2761 gccgacgtcg cctggtcgcc caatccttgg ccgagtcgcg agccgagtcc gatgctcgcc
     2821 acccggtcca ctcatggcct caggtcagca gcatccccag ggctgtgcat ggtgaacctc
     2881 gccttggctg tctgatgagc gacctgtgct ggtcatcccg ctcagctcag cgtcaggtgc
     2941 acgagatcga tctcctggcc ccgggctcgt gcgaagcacc ggctgagccc ggtcaccatg
     3001 aacccgcatt tctccagtac acggatggat ccggcattgt cagcagcggc gtcggcgtgc
     3061 agcggccgag tcctctccaa cttgatcagc tgagcaagtg cctggctggc aatcccttgc
     3121 ccccagtggg gtcgcccgac gacataggtg acttcacgct cggagcgcgg gccgaatatc
     3181 gcgccatgcc ccacgaccag gccgttagta ctgcaaccgc atctggcgtg acggatggtc
     3241 ggcggtctcg ttggtatgac tgtgtgctga tgcgctgacg gttgagcagg tcgagtcgtg
     3301 gtccgagggg gtggccgggc tccatgcccg gttcgcccac cgtttcggca ggtcggagcc
     3361 ccgcgagcgg gcgctggact acctgaacgg actcgtcgcg ccgctggaga agaagaacgg
     3421 gtggacgctg tccgagcagg tcgggcagct ccgcccggac ggcgtccagc gcctgctcaa
     3481 ccactccgac tgggacgaga acgcggtccg cgacgatgtg cgcgacttcg tcgtggagac
     3541 catcggagcc aagaacgcgg tcctgatctg cgacgacacc ggtttcctga agaagggcac
     3601 caagtccgcc ggagtccagc ggcagtacac aggtaccgcc ggccgcacgg agaactgcca
     3661 gatcgggacc ttcctggcct acgcctccgc cagggggcgg gcattgatcg accgtgagct
     3721 ctacatcccc gtttcctgga cggatgaccg tgagcgctgc cgcgcagccg ggatcgacga
     3781 cgagatcccc ttcgcgacca agaatgagca ctgcaagtgg atgctgcaac gtgccgtcga
     3841 cgcaggcatc ccgttcgcgt gggtcaccgc tgacgaggca tacgggcagg tcaagcacct
     3901 gcgggtatgg ctggaggaac gcaggatcgc gcacgtactg gccaccaagg tcaacgacac
     3961 cgtgaccacg gcggacggcg gcgacgccag ggtggaccag ttggtcgccg ccctgcccag
     4021 gcaagcgtgg aagcgggttt ccgggggcca gggcgcgcac ggcgaacgga tctacgactg
     4081 ggcccgcgtc gccatccgcc cgtactggga gaacggcttc gggcactggg ttctggcccg
     4141 ccgcagcatc agcgacccca ccgagatcgc ctactacgtc tgctacggat cggtggcctc
     4201 ccggctgaaa gacctggtca aggtagccgc cgcgaggtgg gcggtggagg agtgcttcca
     4261 gaccgccaag ggcgagtgcg gcctggacca ctaccaggtg aggctctacc gggcctggta
     4321 ccgccacatc accctggcca tggccgccct cgcctacctg accgccgtcc gcgccgcaga
     4381 agccgcaaaa ggggcggagc ggacgacgag caagacctca tacccctcag cgtcccggag
     4441 atccgccgac tgatcggcca catcatcgtc acgccccgcc accacagcaa cgaccatcat
     4501 ctgcactggt cacgcttccg acgacgcagc caggcccgtg cccgccgctc ccactacaaa
     4561 cgccgaggcc acaacccgca gatgcggttg cagtattagc caggacagtt cgcaagatca
     4621 ctgctggatc ggaccggacc ttcgcccagt gctggtcgaa gtggccccgg tcgtagtgat
     4681 atttcctggt cacagccgcc atctgctgca gttccggatc ggtcaactgc tcccagaaga
     4741 ccagcaggtc gctgtcctga agttcgcgca ggtatatttt catgggctcg gtgtcagcct
     4801 ccgcgagatc gttgtcgaag tgatcggctc agcctagggc cagctcacac ctacggaaca
     4861 acctttatgg aggccagctg tgatcgtcag tcagcagcct gctcggccct ggcctgggtc
     4921 tgagcgaggc ggtaggagtc cgtgccggtc tcgatgatgt tcccgccgaa ggtgagacgg
     4981 tcgacgatgg ccgcgcagag ccgggggtcg gtaacgttct tgtcccccct ccgaaccttc
     5041 gttggaggcg atggcgacgc tgttcttttc caccctttcg gttagtacct ggaacagtaa
     5101 ctctgcgccg tgtttgtcga gttccatgta gcccagctcg tcgatcgcga ggagatcggc
     5161 gcgtccgtag cgggcggtcg tcttggtcag ctgcttctcg tcggcggcct tgaccagctc
     5221 gttgaccagc ttggttgcca ggacgtactt cacccggtag ccgaccgtag cggcttcggt
     5281 gcccagcgcg atcagcaggt gggattttcc tgttccggag tctcctatga ggcagagcgg
     5341 gagtcccttt ttcaccaatt cgcaggacgc gagggtgtgg atcacggccg ggtcgatgtt
     5401 caggtcggcg tcgaaatcga attgccgcag ggacttttcc cgggggaatg aggcggcctt
     5461 gatccggcgc tcggagcgtc ggcgggcccc gtcgtcgcac tcggccagca gcagttccgc
     5521 gaggaacccg cggtaggtca tctggccttt ggccgcgtcg gtggcgatgt cggcgaactg
     5581 gctccggatc gtgggcagtc gcagggccct gcaggatgct tcgatggccg cgtgtcggcg
     5641 tacacccgta tctactcggg gcggtacagc cgaaggtgct cagcctcgtc agccgtgacg
     5701 gggatgctcg gcgtaatcgg gaggcgatgc gggcggtcct ggaggtacgc acagttgacg
     5761 gtctcgacct ctggcctgtc gctgaggtcg agccgttcag cttcctgcct ctcagcgggg
     5821 agctgtcatc cgctgaggtg gggacggtgg tgatgcgcat cgccgaccac aacaacgtcg
     5881 actccgatgg cgagcaggcg ccacagccag ccaacgcact cggctctttc tcgcacggac
     5941 tgctcagact tgaggacgat atcgtcgctc ccggcggtct gggagtcatc gatacctcca
     6001 ccagcgtcac cttcctgccc ggctgctgtg acgggctgga gagccggcgc gactggcatc
     6061 ggttcgtcga cgacggcaat ctgctcgggt tcggccacga tcccgtgtca cccgttgcgg
     6121 agcgcttcgg agacatcgtc aggcaccgac tggacatccg agcacgtgcc tgactaccgc
     6181 actcccgtca cagctgctct cgcctgtgtt ctcgacctgc ccgatccggc cgtgagaccg
     6241 gagccatagg gcgatcggct cggctcttcc agcagccaag gtggggccgg gcaaagccat
     6301 cgtgcgtgac gtagtgacca cgttcgcccg tacctgcccg ggtacttcga tgtgcacgcc
     6361 gacacggaac gcggtccacc gttcggtctc cacccgggcc cggtcgaagc caagcacctg
     6421 ggcgacagcc gagttgaggt tgtcgcagcg gaccctgccg gtgggcacac ctgcgagcac
     6481 gctgaaagcg tggacgtgcc cttcgaaaaa ggcctcctgg ccgccggagg cggagacccg
     6541 gtgcaccgcc ttgccggagt acgacaggcg gaaggagaac aggctgcact tgacctgctg
     6601 gccggccaga cggatggtca cgtccccgaa gccgacctcc gcttcggcgc ccggacggtg
     6661 ggactgcggc acgaatgcct tcgcgatgcc ccggcccgca gcgatccgga tctcgtcacg
     6721 acgttccgcg acgtaggcgc ggacgagccc gtatgcaagg tcgacagcgc cgtactcggc
     6781 gaccagccgg tcgaagaccc gcttggccgt gtgctgttgc ttccgcggag cggtggggtc
     6841 cgcccgcagc atctgatcga ccagcccctt gtaggggtcc aggcgcgtct tgcgcaccgt
     6901 ccggaaaccc accccgtact tgtgatgcag agcacggttc gacagcccgg cccgagaatc
     6961 acggcggagc gccgcgtgca gatcgacctt ggacatcggc ggcatacacg ccccctcatc
     7021 acctggagca cttcgatgct cccaccgcaa gcaccccgct ggtggtgaaa ctcagcgata
     7081 ccgatcccag acgagaccgg gtgctgtcgc cgctgaccga caggcggtgc caccactcac
     7141 ccgcacagcc agtcgagcga tgcgtgaaca agtggaagca gttccgagcc gtggccaagc
     7201 ggtatgacaa gcgcgcctac atcttcaacg gcaccctcac cgtcacagcg atcgtcatcc
     7261 tgctccgcga caccgtccaa gagccatcag aaacggccta gtactgcaac ggttcttgtt
     7321 ctgagtgctg ggcagttttc aggggctgtg tccgcgttgt tcgtagtggc tggtgcgggg
     7381 acatcactgt gacgccgctc gcccggtacc cgtcggtgat cggctggctc ccatggccgg
     7441 tcgggtcgcg gtgatgcggg agatggcttc gagggtcaag tcatacgggt gcggttcggt
     7501 ggccagggcg cggtggagcg tcaagccctc gatgagagcg tcgagttggc gggctgtgtc
     7561 cgggtcgaag tgcttctcaa gatggactcg gctgcggcgc atccactcgt gggtgaggtg
     7621 ccggtagatc ggctggcgag cggcgagtgt gtacagctcc tgggtgagaa cgaggtcgcg
     7681 tcggctgcct tcggacagcg cgtgcacgag gtccgccacg gccactcggg cctggtcgcg
     7741 gtcggccgcg gcggcgaggt gggcgtcgaa gaccgcgacg atgtgatcgg cgaagcgact
     7801 gaaggcatcc tggagcagct ggtcgatacc actgaagtgg taggtcatcg atccgagggg
     7861 tacgccggcc cgtgcggcga tcttccggtg cgagacctgc gcgatgccct cttcggcgat
     7921 gaggtcgagc gtcgcggcga tgatgcgttc acgtcgcttc gggtccgtgt gtccggttgc
     7981 catggtgtca ggatcacagg ttccggacgg gtcgcgcggg gttgcccacg gcgacgacat
     8041 cggccggtac gtcccgggtg acgacggcac cggcgccgat gacggagttg tctccgatgg
     8101 tcacgcctgg caggacgacg gccccgcccc ccagccagac gttgttgccg atggtgatcg
     8161 gtttggcggc ttcgagtttg tcgcggcgag gttgcggagc cacgggatgg gtgggggtga
     8221 gcagttggac gccgggcccg atctggcagt cgtcgccgat ggtgatcgcg gcgacgtcca
     8281 gcgcggtcag gttgtagttg acgaaggtgc gggcaccgat cgtgatgttg ctgccgtagt
     8341 cgacgaacag cggtggccgc acgtgggtcc cgtctcccac ggaaccgagg agttcggaga
     8401 ggatggcctg ggcggcagcg gggtcctcga tgtaggcagc ctggtagcgg gccgccagca
     8461 tcccggcccg ccgcagctta cgggcgatct cggggtcgtc ggcgatgtag aggtcgcccg
     8521 ccaacatgcg ttccagattc gtgcgcgggt ccagcgcgaa gtattcctcc gacatgtacg
     8581 caacatacag cccaagcgta cgaacgtaca tcccgggctg tcgcgggccc cggcgaacga
     8641 ggtcggccgg cctggggact catgcgcgcc gggtctgcag aactcccgcg agcagcatca
     8701 cgagcagtcc cgcgagcggt atcaccaaca gcccggtccg aaggccggcc gcatcggcga
     8761 cgagcccgac gaccggtggg gagaacagga agcccaggcg catgagccag gaaatgatcg
     8821 tgagccccga tcccggcttg agaccgggga gttcgtcggc tgcctgaagt gtggcaggca
     8881 ccagggtcgc cactccgaat ccggccgcgg cgaaaccgag gaccgtcccg gggacggtag
     8941 gcacggcgag ggccaggccc atgcctgccg cggcgacgaa gccgccgaca cgggccacgg
     9001 agcgctggcc gaaccggtcg acgagccggt cgccgatgag gcggccgacg aactgagcac
     9061 cgaccagggc gatgtagccc caggccgcct gcgccgccgt cgtacgcagg gagtcggcga
     9121 gatagacggc ggcccaggaa ctgccggcct cctcgacgag tgtgccggcc acggcgatga
     9181 ggacgagcgc ggccagcacg agacgggggt gcgtgcccgt cgcggctcgc cgtgtccgct
     9241 gtggtgggcg ggcttcggcg tcagggtccg cggccggctc ggtttcggga ccgggcaggc
     9301 agaaccgcag ggcgacacag gccacggttg cgcacagcgt cgccgagatc agcaggtgct
     9361 gtccccggga gagtccgagc gcgatcgcgc cggcccccat ggatccaccg actacggctc
     9421 cgatggacca gacggcgtgg aaggagttga tgatcgagcg tccgtagcgg cgctgtacac
     9481 gcaggccttg ggcgttctgc gcgacatcgg tgatcgcgtc cgtcgctccg gccaggagca
     9541 acgctcccgc gaacaccatc accgagtccg ccatgccggc ggcgagtatt cccatgcccg
     9601 tcagcgtggt accgatgacc gccactcgtg ccgagcccat cctgcggatg aggatcgagg
     9661 ctgccatccc ggccgcgatg gcgcctgccg ggaaggccac cactgccagt ccgtaggccg
     9721 cgttgccgat gccgagatcc tccttgatct gcggatacct cggcagaaga ttggcgagca
     9781 gggccccgtt ggtgaagaac agcacggcaa cggccacacg ggcctgccgt gcggcctggg
     9841 caggtccgcg cagggtgtca acagtcatgc ggggacctta caagcagagc gtacgaacgt
     9901 acactctgcc tctgtccgga gcccggggga ggagggggag tgcccggtgc cctgccgttt
     9961 cttcggcagg gcgtcgacga ggtcggctac cggctgccgg ctaccggctg ccgcgcctgg
    10021 ccgaggccgt ccggtgcggc gaggcgcgct tcacggtcgg gcgccgaggg acgagccgtg
    10081 gtgcgacgtc ggcctcggtg agagccacca gggcggcgtg gtcgggggag agggaacagg
    10141 ccgggtcggt gcgggtggca tcccccgtca gggcgtgggc ctggcaccgg cagccgccga
    10201 agtcctcggt gcggcgctcg caggaacggc agggagaggg catccagtcg gtaccgcggt
    10261 aggcgttgaa ggccggtgac tcctcccaga tccagcgcag cgaccggtcg gcgacgttcg
    10321 gcgggtccag gccgggcagc gacgccgcgg ccgggcaggg cagggccgtg ccgtcgggcg
    10381 tgacggtgag cgatacggca ccccagccgc ccatgcacgg cttgggcgtg ccggagaagt
    10441 agtcgggcac cacccaggtg atgtccaggg tgccgtccag acgcttccgt tcgcgctcca
    10501 ccacctcgcc ggccgcccgg agttgttccc ggctcggcat gagcgcggcc cggttgagca
    10561 ggccccagcc gtagaactgg gtgttggcga gttcgacgcg gtccgcccgc cagtcgacgg
    10621 ccagggcgat caggtcggcc acggcgtcga ggttgtggcg gtgcaggacc acgttgacgc
    10681 cgagcgggag gcaccgctcc ttcacgagcc gggccgccgc cagcttggcg tcgaaggacc
    10741 gacggccggc gatctcgtcg gagcggccgg gatcggcgtg ctggacggac aactgcacac
    10801 tgtgcagacc ggcgtcgacc aaggagtcga tccgttccgc ggacagaccg tcgccgctgg
    10861 tcaccagctg ggtgtacagc ccggcgtcca ccgcggaccg ggtgatctcc tccaggtccc
    10921 ggcgcaacag gggttcgccg ccggagagat gggtgtgcag tacgccgagc tccgctgcct
    10981 gccggaagac gtcggcccac tgtgacgtgc ccagttcctg tgaacgtcgg gtcagttcca
    11041 gtgggttgga gcagtatccg caccggagcg ggcaggcgtg ggtcagttcg gagagcaggg
    11101 cccagggcgg agcgggaacg gtcatcgcag acagccttcc gtgcgcagcc ggtgcaggaa
    11161 cgaagtgacc tcatggcgta cgcgggactc gccgccggcg ccggcgccaa tgtcggtgtc
    11221 ggcgccggcc gagaggcgtg cggcgatctc gtcgacggtc cggctgccgt cgcacagttc
    11281 gaggacggcc cgcccggagc cgtgcaggac gacgacccgt tcggggagca gcaggacatc
    11341 ggccccccgc acccggtcgt ggcgcagcac cgccgccggg aggacacggg gccgccagag
    11401 ctgtggctcg cccatcacgg tgtctcccgc cgctccgccc cctgcacgct gtcgagcagg
    11461 ctccacagca cgtcgcactt gaacgagagg gccgcgagcg cgcggtcctg ctggtcgcga
    11521 ctcaccgccc actccttcac ccaggccagt gcctcgcttc cgtcgcggcg tccctggggg
    11581 acacggccgc ggaagtagga cagaccggcg gaatcgatcc aggggtagtg cagcggaaac
    11641 gtctccagac gggtcagcat gatcgatggt gcgcacagtt cggtcaggga cgaggcaacg
    11701 gcttcgagtc tgtcgttgtt gcggcagaag ttgacatagc cgtcgacggc cagccggaca
    11761 ccgggcagca gatgccggtg agtcagcagt tcatgtcggg cgagacccac cgcctcgccc
    11821 aaccggagcc acttctccag tcctccgtcc tggtcggtga gcccgtcgtg gtcctggatg
    11881 cgccggagcc aggagcgacg ctgggcgggc aggtggagct tggccaggat gtgggcgtcc
    11941 ttgatgggga tgttgcactg gtagtagaag cggttcgcca cccagagccg tagttcggcg
    12001 gggctcagtt cgccttggtg catacgccgg ttgaaggggt ggcggtcgtg gtagcgggcc
    12061 gtggccagct cgcgcagccg ggcctccagt tgctcctcgt cccacgcgcc gaggcccggg
    12121 ctgcccgggt cggccccgcc cggctccggc cgtgtggcga gggcggtctc gaagccggtc
    12181 gtggtcacag ggacaccacc atcctgtcct cggccacgcg caggcccagg ccggcgagcc
    12241 gttcgtgtgc ggggtcgccg gggtcgacca gcgggttcgt gttgttgaga tgggtgtagt
    12301 agacccgcgc gccgacccgg ctcaggcgtc cggcggtgcc ttcgggaccc tcgatgggca
    12361 gatgccccat ccccgaggcg gtgcgtcggg agatgccgag gcggcgcggc tcgtcctcgt
    12421 cgaggaaggt gccgtcgagc agcacgcagt cggttccggc gatctcgtcg ccgagggcgt
    12481 cgctccaggc ggcgagggcc ggcgcgtaca gcgcgctcct gcccgtctcc gggtcgtgca
    12541 cgttgagtgc cgtgctccag gcggggtggg ccggttcgtc cgccgcgtag cgcggtcgtt
    12601 tgtccgacag gggcagggcg ctcacccgca gtcccgcgat ctcggccggt tcgccgacgc
    12661 cggtcagtgg gagttcgtgc caggtgaggg tggtgtaggg ggagaggatg tcggtgagcg
    12721 gcagccgtgc ggtcagggcc ttgtgcacgg gttccgtgca ccagacatcg atccgcgcgg
    12781 cctcgcgcag ccgcagcagc ccgagggtgt ggtccagttc cgcgtcggtg aggacgaccc
    12841 ggatcacggg ggtgcgttcc tgtccggccc cgggccgcag cgaggggtgg ccttccagct
    12901 gttcggcgac gtccggtgtg gcgttggcga ggaaccaggc gcccgggtcg gccgcgtgca
    12961 cggccaggcc gtcatggagc cggcggcggg aggggtgccg gcgtgccccg gcgcagccgg
    13021 ggcacgcaca gttccactgg ggtaggccgc caccggctgc tgtcccgaga acgcgcagca
    13081 gcacggccgg cgcctacttc tcgcgcagcg agtaggcggt gacctccagg gcggtgtcga
    13141 ccaccgtgaa gtcgggggtc tgccagtcgg cggacggctg cccggacggc tggggctggt
    13201 ggtggagctg gggctgcggt tcgttgtgca tgacgacctg cctttcgagt gggtgacgta
    13261 ggtgtggcgg ttgagatgga tgtggtgggt gtggaacgga tcgcgggtcc cgggacccgc
    13321 gatgcccggt ggccgccgcc cgccgacggc ggccacacgt catgtgcaga acggcttctt
    13381 gcccatggcc gactcgatgc cgccgaggat cagcttctgg aactcggcgg ctcccgggaa
    13441 ggatccgtcg gtgctgaagg ccttggcgtc gtgtccgagc gtggtgagcc aggcgcgacc
    13501 gccgtcgtag tactggcacc aggcgaccgc gtggtcgtcc ccgtgcccgg ggtggtggta
    13561 gttgcccttg acgcccctgg cgagggtggt ctcgtcgacc tcggcgagga cacggacccg
    13621 ggtcggggcg ggtacgaggt tgtaccactc gtcggagaac tcccacctgc gcggcagcga
    13681 cttggtggag gcgtccttgc tgttgacggt gcggaccgtg ccgggctgcg cgggaccgtg
    13741 gtcgtagaag ttcgcgttcc cgagcagacc ctcgtaccag ggccagttgt actcggtgcc
    13801 gaaggcgttg tgcaccccga cgaagccacc gcccccgcgg atgtactgtc gcagcgacgt
    13861 ctgcgccgcg tcgtcgagcg tgtcgcggct ggtcgagaag aagatgacgg cgttgtactt
    13921 gaacagggcc gcggccgagg cgagttgggt gacgtcctcg gtgtagtcga cctggaagcc
    13981 gttgtcggac cccatcctca gcaaggcctt ctgcacgacg ttggcgtcgc tcaccggagg
    14041 gttcagcccg gtgcccaggg cggggccgag gttggcgtgc cgggggccgg cggtacgggt
    14101 gtacagcagg accttgaacc ccttggaggt gtcgaagttg ccccagtcgt ggtagcagcg
    14161 cacgtccaca ccgcggcaca cgccgtagtc ggggtcgcct agttgccggg ccccccggtc
    14221 gccgccgccc tgagcgacgc tgagtgtgcc ggtcgccacc agcgcgaccg tgatgccgag
    14281 ggttccggcg acactggtga gagcggcggt gagaggtcgg atacggcgtc tcggtctggc
    14341 ggttgtcgtc atgcggtggt cctcacggtg tctggtggcg ggtgaggtgg tgccgggcag
    14401 cggtgcgcta cttcacgacg accttgccgg tgctctgcgg cgcggccggg tcgttgtaga
    14461 agtactcgcc gggggtgtcg aacgtgtacg tgtaggactg gcccggcatg agcaggccgg
    14521 tgtcgaactc ggcgtcgaag aaggcgaccg cgccgtgcgc ggacctgttg tcggccgggt
    14581 tgacgaaggt gacggcggtg cccttggcga tgctcaggtg ctgcggcgac atggcgttct
    14641 ggaccacgag gttctcggtg gtgccggggg cgttcttggc gctgtcccag acgcggccca
    14701 gggtgatcgt gttctgggcg gtctcgccgg tgacggcggc ggtccggatc tggttgcgcc
    14761 tggacggcgg tgtgggtgcc gccgcgggct ccacgctccc ccctatcttg aacgcccaca
    14821 gatggtcgcc cttggggatg tccgggtagg gcaggccgtt gcctccggcg agtacggcga
    14881 cgtactgctc accgtcgatc tcgtacgtca gcggactggt gtggacgccc gctccgcact
    14941 gccaggtcca cagttcgctg ccgtcacggt cgtcgagggc ggtgagcaca ccgtcgggcc
    15001 ggccctggaa gaggacaccg ccggccgtac tgaggatgct gttgccgtgt gccagggacc
    15061 agtcgccctc ctgccgccag gcgaccgtgt tggtgcgtgg gtcgaccgcg acgaggccgc
    15121 cggcgaagta ctcgccgagc gggcgcgcgg tgttgacccg gccgccgtgt gtgttggagt
    15181 aggcggagtt gatcaggccg tagccgacat agaccaggcc ggtgcggtgg ctgaaggagg
    15241 ggaaggacca gtcggcggcg ccgcccgcgc cggggaacag gatcgtggcc cggtcccagt
    15301 ggacctcgaa caggccgccg gtggggtaga agggcaccgg ccgggtggcc ttgtcgaagc
    15361 gcggtgcggt gtcgacgaag ggctcgccgc ccgggaaggg ctgggtgggt gaggtcttct
    15421 gcgccttgtg ctggggcacc ggccgttcct ccatgccgtg cacgggttcg cccgtcgcgc
    15481 ggtcgaggat gtagtacatg ccggtcttgc tgccgtagac gacgacccgg tgcttctttc
    15541 ccttgatcag gatgtcggcg agcaccgggg acatgacccc gtcgtagtcc cagatgtcgt
    15601 ggtggacgga ctggaagtgc cagcggcgct cgccggtctt ggcgtcgatg gcgaccagac
    15661 tgttggcgaa gaggttgtcg ccgccccggg tggaaccgtc ggtgcgggga taggggttgc
    15721 cgaacgtcca gtagacgatg cccagttcgg ggtcgaccgc gggatggatc cagcacaccg
    15781 cgccgccggt cttccaggtg tcgccctccc aggtgtcgtg accgtactcg ccgggaccgg
    15841 gggcgcccca gaagacccag gcgacctcgc cggtggaggc gtccagcgcg tacgcgcggc
    15901 cccgcgcgcc gccggtgctg ccctgggtgc cgatgtacac cagcccgtcc cagtacacgg
    15961 cggctccggc cagactgccc ctgccgctgc cgtcctcggt catgagttcg cgggaccaga
    16021 cgaccgcacc ggtcttctgg tcgagggcgt gcaccttgtt gtcgccggag atggtgaagg
    16081 ccaggccctt gccgagggcg agacctctca tgttggtggt tctggtaccg accttcgtct
    16141 tccacttcac gtcgcccgtg cgaccgtcga cggcgaagac gttctgctgg gtggtggcga
    16201 ggtagaggac accgtcctgg gcgatgacgg cgcactgctg gtggttcgag gtggagccgc
    16261 cctccaggtt cacatgccag gcgccgccca gcttgccgac gttcccggcg ttgatcttct
    16321 tcagcgagga gtggttctgg ttgccgaggt tgccgccggc cttgggaaag ttcctgccgg
    16381 tggcggcgtg ggactgggtg ggcaccgggc ggcctaactt gtccggtgcg gccgcctcgg
    16441 cggtgccgtt gttgaggagg gcgacggtgg tcgccgtccc ggcggctgtc gaggtgagga
    16501 aactacgtct gtccatggtc cctctttcat ggcgggtgcc tggcgggcgc tgacggacac
    16561 gtcggtgacg gtgccgatgt gtctcagctg gggagggagg agcgaggagc gaggagcgaa
    16621 gcggatcatg gtccgctgta cggttcgagc gatccgtacc gtggttgccg atgggcggaa
    16681 agctacgtta gggatgtgcc acgggtgtga caaggggggc gacgtggatt gtcacgggtc
    16741 tttcggctgc ggcagccggg ccggcagcac gttgcgcgga agggggccct tgttgcggcg
    16801 gccctgtccg ctctcctccc aggcgtgggc gaggatcccc acggaacggc tgagcacgaa
    16861 caggccccgg gcgagcggcg cggcgaagcc cagctcggcg tagatgacgg ccgtcgcgcc
    16921 gtcgatgttc atcgggaccg gccgggctcc ggccctgcgg cggcgcaggg cctcctcgac
    16981 ggcgagggcg ccgtccagga agtctccgcc gacgacgccg tcggcgaccg cctgccgcac
    17041 caggccgagc agggggccgc tgcgggggtc gacggggtgg aagcggtgcc cgaacccggg
    17101 gagatagcgg gaacggctct gccatgcggc catgacctca tgggcggcgt cgtcccagcc
    17161 gaggccggag gtgtgcaggg tacggatgtc ggtgagcatc tccacacact gctgacccgc
    17221 tccgccgtga gcgtccccca gcatgttgac tccggtcgcg acggcgttgt tgagcccgat
    17281 cccgcaggtc gccgccatcc gggcggcggc gatggagggg gcctgggggc cgtggtccac
    17341 gcccgcgacc aacgccgctt cgagcagggc ggattccggc ggtgagggcg tcgtgccccg
    17401 cagcatcagc cagatgacgt ccaccaggct cgccctgccg atgagatcct ggaccggtcg
    17461 gtcgcgcagt tcgatgctgc cgggctcgat atggctgacc gccgtggccc accacagggc
    17521 ggcctcgtcc ggggaactcg tcatgaggcg gcggcctctc cggcggacgc ggtggccccg
    17581 gccaccgggg tggaccagcg tcgtgccagc ttccgtccct cggtgttgtg ctggcccagc
    17641 aagggtggcg gagcgggcgg accgaacgac tccccgtcga cgagcacacc gcttcccacc
    17701 acccggagcg gctgccccgc gcgtcccggg tgactcagct cggtgacgaa gccgcggtac
    17761 gccagttggg gctgctccag ggcctcgggc acggtcagga cacgagccgc gggcacaccg
    17821 gcggcgttca gctcgcgttc ccagtcggcg gccgggcgtg cggccagggc ccggttcagc
    17881 gcggtgttga gctcggcccg gtggctcttg cgcccttcgc gctcgctgaa gcggacgtcg
    17941 gtgatcagct cggggacgcc cgcgagacgg cacagggtct cgaactgctg ttgctggttg
    18001 gcggcgatgt tgagcgggcc gtccagggcg tggaaggtgc cggagggagc ggcggtcgga
    18061 ttctggtcgc ccagcggctg tggcgggacg ccgctgacga ggtagttgga gacggcccag
    18121 cccatcgcgg acagcgacgc ctccagcatg gagacatcga gtctgctgcc ggcaccggtg
    18181 cgctcgcggc gcagcagcgc ggcactgatc gcgaacgccg ccatcagccc tcccgtggtg
    18241 tcgcagaccg ggaagccgat gcgctgcggg gcggtgtcct cggtcccggt gacgctcatc
    18301 attccggtca ggccctggac gatctggtcg taggcgggag cgtcactcag cgggccggtg
    18361 tgcccgaagc cggagatgga gcagtagacg aggcgttcgt tgagctgggc gaggcgttcg
    18421 gcgccgtagc ccatcctctc cagcacgccc gcccggaagt tctccagcag cacgtccgta
    18481 ccggtgagga gttcctcgaa gagggcccgg tccgccgtgt ccttcagatc gagttcgagc
    18541 gacttcttgc ccgcgttctg agcgaggaac gaggccccga ctccgtcacg gttgagcgag
    18601 ggatcggggc cgaggctgcg ggcgagatct ccctgcccgg ggcgttcgat cttgacgacc
    18661 tcggcaccca tgagcatcag ctgatagctg cagtagggcc cggcgagtac gttcgtcagg
    18721 tccagaacgc gtactccgtc aagtgggcga acgtgcatac agcgtctcct tccagcggta
    18781 ccgcgcgcgg ctccgctgtc ggcgtactgg ctaggttcgc ggccccaggg gatgctggaa
    18841 gccctgcgag gcgatgcggg cggccgtctc cagcagatcg cccgcgaagt cctcggtggc
    18901 tcccgccggg atacgcgcgc tggggccgct gagcgagagt gaggcgacga ccacccccga
    18961 ctggctgcgg atcggtacgg cgacggccgt gaggccgaca tcgcgctcac cgtggctgac
    19021 cgcgtaaccg tgggtcgccg actcctgcgc ccacagccgc aactgctcga cgtgcggcac
    19081 tccgtggggc gagtcggcgg cgatccgttg cagaaggccg tcggtggcac cgatgagcag
    19141 caccttggag gaggcgccgg cccacagggg cagttcgtcg cccacgcgca ccacatgccg
    19201 caggggctgc gggctctcct gctgggcgac gcagacacga tggatgtcgc ggcggatcat
    19261 gagattcgcc gtctcgcccc gtcgctcgac cagctcgcgc agcaacttct gtgtgtcggg
    19321 cggcagttcc cagctggtgt gtgccagatg ggcccagcgc cacaggccgg ggccggccgc
    19381 gtaaccgccc ggtgtggccc agagcagtcc gtactgctcc agggtctgca ccaggcgtac
    19441 cacggtggtc ttgggcagac cggtggcgtc gaccatgttc ttcagaggga cggtgggctg
    19501 atcctcggtc agcagcgaca gaatgtccag agcgcggcgc acgctgcgta caccgccgcc
    19561 cggtccttgc tccgcgtcca cgttctctcc ttcgcgagtg ggggaccgcc gctgcccggt
    19621 gaacgggcgc gacgtctgga gcgacagctt ccatcagggg agccgtcttc ggaaatcccg
    19681 ggtcccaact tcctggcgcc gacctattgc cacggtctcc tggtgcccgt acgttacacg
    19741 ccagtccata gagcagtcca cgaaaaccat cagatggttt tttggggaga cgtgatgctg
    19801 caagacctgc tcaaggccgc cgaccagaac gaggtggtcg aggcccttcc ctatctgtcc
    19861 ggatcgtggg gtggtgaggg tccacccctg gaacgcaccg gtccctacct gcggcgcacg
    19921 gtcagtcgcg tacccaccgc gacggccggt gacatcgaca ccgccgtgac cctggccggc
    19981 cgctacgccc ggcagatggc cgatctcgcc cccgccgcgc gggccgacat cctggaggcc
    20041 gccgcacgcg gcgccaccgc ccagcgcgac cggctcgccc gcctcctcgc cctggaactg
    20101 ggcaaaccgc tgaaggacag tcgcaccgag atcgaccggg tggcctccac gttcgccgtc
    20161 tgcgcggccg aggcccgccg cgtcgacggc gagaacctgc ccgtggccgg ctggaacacc
    20221 ggcatcggca acactgccct cacctaccgg gcaccggccg gcgtggccct ggcgatcacc
    20281 ccgttcaacg cgcccgccaa cctgctcgcg cacaagctgg gcgcctcctt cgccgcgggc
    20341 aacaccaccc tggtcaaggc tccgccccag gccccggcca cctccgccgc cgtcgtcgcc
    20401 ctgctcctcg acagcggcat gccccaccag gcggtccagt tgctgcacgg cgggggagag
    20461 gtcggcgccg ccctgtgcgg cgccgacgcg gtgagcgtca tcagcttcac cggcagcgcc
    20521 gagaccgggg cggcggtggc ccgtgccgcc ggcgccaaac ggctggccct cgaactcggc
    20581 gggaacgccg cgaccgtcgt ctgcgaggac gccgacaccg ccgccgcggc gaaggtctgc
    20641 gcgcgcaccg gctacagcaa ctccggccag agctgtatct ccgtacagcg ggtgtacgtt
    20701 caccgcggcc gctacgagga gttcctcgac gccttcacgg cggcggtcga cgacctcgtc
    20761 atcggtgatc ccctgctgga gaccaccgac atcggctcca tggtcgacga gaacgcggcc
    20821 gaacgcgtgg tggcctggtc ggaggaggcc cggcgactgg gcgcgcgcgt gatccggggc
    20881 ggcacccgcg acggcgccac cgccgcaccg acgatcgtcg ccgacccgcc cccgcacgcc
    20941 tcggtggtcg tgcacgaggt gttcggcgcg ctggtctccg tactgcccta cgacgatttc
    21001 gacaccgtga tcgagcagtg caacaccagc cggtacggac tccaggccgg cctcttcacc
    21061 cacgacatca cccgtatcct caccgcctgg cggcgactgg aggtcggcgg actgatcgtc
    21121 aacggctcct ccaacttccg cctcgaccac gtgcccttcg gcggtgtgaa ggactccggc
    21181 ttcggccgcg aggccccccg ctggctgatc gacgactaca ccgtcgtcaa gaccctcatg
    21241 ctgcgcggcc tgtccgtctg gggcgacagc cgcgagctgc ccaaggagaa cccgtgacca
    21301 ccgtgaccgc cgccgaggcc ctcgtcgccc agctcgagtc gtacggcgtc gaatacgtct
    21361 tcggtacctg tggacacacc aacatcgccc tcctcgacgc cctcggaccg agtgcgatcg
    21421 aattcgtcat cgcccgtcac gaacaggccg ccgcgcacgc cgccgacggc tacgcacgcg
    21481 ccaccggccg ccccggcgtc ctgctcaccc acgtcggccc cggcatgatg aacgccgtca
    21541 ccggcgtcgc caccgccgcc ctggactccg tcccgctggt cgtcatcacc ggcgacatcc
    21601 cctcctacta ccacggccgc catccccacc aggaggtcaa cctccacgcc gacgccgacc
    21661 agagctccat ctaccggccg ttctgcaagc gcacctgggc ggtgcagcgc gtgcgggacc
    21721 tgccgcgcgt caccgagcgg gccttcttca cggccgccag cggacgcccc ggcgccgtcc
    21781 tggtcaacat ccccatggac ctcttcaacc ggcaggtctc gccctacgcc gacggccacc
    21841 cgctccccgg ccacctcggc aggcccggac tggacgagca gaccgccggc cggatcgccg
    21901 acgcgctgct cggggcggag cgcccgctga tctacttcgg cggcggctta cgcggtcccg
    21961 ccgcccgcgc cgaactgctc accctggccg agcacctcga catccccctc gcccactccc
    22021 tcatgggcaa gggcgtcatc tccgaccggc accccctgct cctgggcatg cccggcttct
    22081 gggggctgga gaccacccac gaacacacca ggggcgccga cgtcgtgctc gcgctcgcca
    22141 cccgcttcgc cgagacggac gccagctcct gggacgccgt ccacacct
//
