LOCUS       NZ_CP045096            12979 bp    DNA     linear   CON 20-NOV-2024
DEFINITION  Streptomyces phaeolivaceus strain GY16 chromosome, complete genome.
ACCESSION   NZ_CP045096
VERSION     NZ_CP045096.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces phaeolivaceus
  ORGANISM  Streptomyces phaeolivaceus
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 10116136)
  AUTHORS   Mo,P.
  TITLE     Streptomyces sp. strain GY16 isolated from leaves of Broussonetia
            papyrifera
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 10116136)
  AUTHORS   Mo,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-OCT-2019) College of Life Science and Technology,
            Central South University of Forestry and Technology, No. 498,
            Shaoshan South Road, Changsha, Hunan 410004, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 15-AUG-2019
            Assembly Method                   :: HGAP v. v. 1.3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 120.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_009184865.1-RS_2024_11_18
            Annotation Date                   :: 11/18/2024 02:51:11
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,113
            CDSs (total)                      :: 9,024
            Genes (coding)                    :: 8,642
            CDSs (with protein)               :: 8,642
            Genes (RNA)                       :: 89
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 382
            CDSs (without protein)            :: 382
            Pseudo Genes (ambiguous residues) :: 0 of 382
            Pseudo Genes (frameshifted)       :: 112 of 382
            Pseudo Genes (incomplete)         :: 305 of 382
            Pseudo Genes (internal stop)      :: 23 of 382
            Pseudo Genes (multiple problems)  :: 53 of 382
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:44:39
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 8979277
            Orig. end                         :: 8992256
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP045096.1.
            Bacteria and source DNA available from Yunlin Zhao.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..12979
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="hydrogen-cyanide"
                     /region_number="30"
                     /rules="(Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD) and DAO)"
                     /tool="antismash"
     cand_cluster    1..12979
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD)
                     and DAO)"
                     /kind="single"
                     /product="hydrogen-cyanide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..12979
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:7979](-)"
                     /cutoff="5000"
                     /detection_rule="(Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD)
                     and DAO)"
                     /neighbourhood="5000"
                     /product="hydrogen-cyanide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..7979)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="(Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD)
                     and DAO)"
                     /neighbourhood="5000"
                     /product="hydrogen-cyanide"
                     /protocluster_number="1"
     gene            95..1561
                     /locus_tag="F9278_RS40950"
                     /old_locus_tag="F9278_40970"
     CDS             95..1561
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012999154.1"
                     /locus_tag="F9278_RS40950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F9278_40970"
                     /product="tetratricopeptide repeat protein"
                     /protein_id="WP_152172832.1"
                     /transl_table=11
                     /translation="MVTDRYGNRLHECTAEGAGHLDRAVEGLLFFRPDFPTAVADAVAA
                     CPTSPMAQAFSAYLGVLGTESRDAAEARRRFTEFGAGLDHSALPRRERMHMAAAEAWLG
                     GDLGRAGQVLEELVVECPRDPLALAVGHQLDFFTGDATRLRDRIGGALPSWDEDDPHRG
                     PLLGMYAFGLEESGHYGRAQEVARAAVERNAHDIWAIHAVVHVHEMQGRFAEGIDFLDA
                     RLDGWASGSLLTVHSWWHYALYALEAGDTGTALRVYDAVLHHKDSSGFVMELLDAASLL
                     WRFLLDGSDQDARWQALADAWAAREDPPFYAFNDAHAVMAFAGAGRLDTADEFVADRRR
                     WLTEARRGGPSGGDTNRVMTGEIGLPVCEALVAYAREDYAAVVDLLWPVRRRLHTFGGS
                     HAQRDVIQRTLLEATLRARRDDLARLLLGERTGLSPHSPYNWLGQARLADALGEAGRAA
                     VARDTATELAAPAAQRLSRNPHDTYLVRRP"
     gene            complement(1670..2197)
                     /locus_tag="F9278_RS40955"
                     /old_locus_tag="F9278_40975"
     CDS             complement(1670..2197)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010988597.1"
                     /locus_tag="F9278_RS40955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F9278_40975"
                     /product="NUDIX hydrolase family protein"
                     /protein_id="WP_193242092.1"
                     /transl_table=11
                     /translation="MTETTPGWLPSDELESARARMPILYVEAVPVRVDDSGEVTSIGLL
                     LRIGPDGTVSRNLVSGRVMHHERVRDALLRHLEKDLGPVALPRVPSALQPFTVAEYFPT
                     QGITPFHDPRQHAVSLAYIVPVAGDCRPRQDALDLVWFSPQDAASESVQSEMPGGQGVL
                     LKQALAHVGCLS"
     gene            complement(2307..2990)
                     /locus_tag="F9278_RS40960"
                     /old_locus_tag="F9278_40980"
     CDS             complement(2307..2990)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1071: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012999152.1"
                     /locus_tag="F9278_RS40960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F9278_40980"
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_152172834.1"
                     /transl_table=11
                     /translation="MAPSAPAAGPALPVLGGKKSSYRERVADALRAALIAGELRPGEVY
                     SAPGLATRFGVSATPVREAMLDLAKEGLVDTVPNKGFRVTVVTEKQLDEYTHVRALIEI
                     PTTVGLARTADPVSLEALRPAAREIVAAAAAGDLVAYVEADTRFHLGLLALAGNAHLVE
                     VVGDLRKRARLYGLTALAESGRLLSSAQEHLELLDALLARDEAAVHTVMTRHLGHVRGM
                     WAAHD"
     gene            complement(3001..4002)
                     /locus_tag="F9278_RS40965"
                     /old_locus_tag="F9278_40985"
     CDS             complement(3001..4002)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010358096.1"
                     /locus_tag="F9278_RS40965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F9278_40985"
                     /product="proline racemase family protein"
                     /protein_id="WP_152172835.1"
                     /transl_table=11
                     /translation="MRSTLVLHAVDSHTEGMPTRVITGGIGTIPGATMNERRLWFREHR
                     DDVKQLLMNEPRGHAAMSGAILQPPTRPDCDYGVVYIEVSGYLPMCGHGTIGVATVLVE
                     TGMVEVVEPVTTIRLDTPAGLVVAEVAVEDGAARAVTLRNVPSFSVGLDRKATLADGRT
                     VTYDLAYGGNFYAILPLEQFGLPFDRDRKDDILKAGLALMDAINAEEEPVHPEDPSIHG
                     VHHVHLYAPGATARHSRHAMAIHPGWFDRSPCGTGTSARMAQLHARGELPLHTEFVNES
                     FIGTHFTGRLLGETEVAGVPAVLPSFTGRAWITGTAQYLLDPTDPFPSGFVL"
     gene            complement(4027..4926)
                     /locus_tag="F9278_RS40970"
                     /old_locus_tag="F9278_40990"
     CDS             complement(4027..4926)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019069839.1"
                     /locus_tag="F9278_RS40970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F9278_40990"
                     /product="dihydrodipicolinate synthase family protein"
                     /protein_id="WP_152172836.1"
                     /transl_table=11
                     /translation="MTGSPNHHPWRGVLVATALPLRDDLSVDHDKYAEHCAWLVENGCD
                     GVVPNGSLGEYQVLTPEERAKVVETAVAAIGGSRVMPGVAAYGSAESRRWAEQARDAGC
                     ASVMLLPPNAYRADERSVLAHYAEVAKAGVPVVAYNNPIDTKVDLVPELLAKLHGEGCI
                     RAVKEFSGDVRRAYQLAELAPELDLLIGADDVLLELALAGAKGWVAGYPNALPAATVEL
                     YHAAVDGDLATAKALYAQLHPLLRWDSKVEFVQAIKLSMDIVGRHGGRCRPPRVELLPE
                     QEAVIRAATEKAVAAGLA"
     gene            complement(5001..6515)
                     /locus_tag="F9278_RS40975"
                     /old_locus_tag="F9278_40995"
     CDS             complement(5001..6515)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     hydrogen-cyanide: Fer2_BFD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     hydrogen-cyanide: Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1176: alkyl hydroperoxide reductase subunit"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020118954.1"
                     /locus_tag="F9278_RS40975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F9278_40995"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_152172837.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1.6e-23, bitscore:
                     82.4, seeds: 64, tool: rule-based-clusters)"
                     /sec_met_domain="Fer2_BFD (E-value: 1.1e-12, bitscore:
                     47.2, seeds: 211, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTDPTRSHAPGPPHLAIIGAGPAGLAAALAAAGEGVRVTVVDAA
                     RAPGGQFYRQPAAGLGARRPGALHHQWRTWRRLRDGLRRQIDAGHVTHLPDHHVWCVER
                     RPEGGGIDGGPARLTVHALLGPGQETPAEVRADAVLLATGGYEKVLPFPGWTLPGVVSA
                     GGAQAMLKGGLVVSGRTAVVAGTGPLLLPVATGLAAAGVTVAALVESTGPRALARRAGA
                     LAGRADKLAEGAGYAVELLRRRVRTLVRHTVVEAHGADRLEAVTVAALDAEGRVRPGSE
                     RRIPCDTLAVGHGMLPHTDLAETLGCRVESPGQRVWVDGEQRTDVPGVWAAGETTGIGG
                     AALSLAEGHIAGRSAAARLRGWVPDPGTWAGAAESRAELRRFFEALDTVYVPPAHWTEQ
                     VRDDTVVCRCEEVTAGAVREAVGELGAGDVRTVKLLTRAGMGWCQGRMCGPAVAGIAGC
                     EQAVARRPFAQPVPLGVLARTGEVRTGEVRTGEVRTGESEQDDDDR"
     gene            complement(6505..6804)
                     /locus_tag="F9278_RS40980"
                     /old_locus_tag="F9278_41000"
     CDS             complement(6505..6804)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     hydrogen-cyanide: Fer2_4"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005484543.1"
                     /locus_tag="F9278_RS40980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F9278_41000"
                     /product="(2Fe-2S)-binding protein"
                     /protein_id="WP_152172838.1"
                     /sec_met_domain="Fer2_4 (E-value: 2.3e-26, bitscore: 90.7,
                     seeds: 114, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKPMELARAEPGPAFTVTLDGRQLDALPGQTVAAALWAAGVTSWR
                     STRGEGRPRGIFCGIGVCFDCLITVNDRPNQRACLIPLRPGDAIRTQEGTGHEH"
     gene            complement(6801..7979)
                     /locus_tag="F9278_RS40985"
                     /old_locus_tag="F9278_41005"
     CDS             complement(6801..7979)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     hydrogen-cyanide: DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1103: FAD dependent oxidoreductase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676295.1"
                     /locus_tag="F9278_RS40985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F9278_41005"
                     /product="FAD-binding oxidoreductase"
                     /protein_id="WP_152172839.1"
                     /sec_met_domain="DAO (E-value: 2.8e-63, bitscore: 213.7,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTERLTCDVVVVGAGMVGAACALYAARAGLSVVVVDRGPVAGGTT
                     GAGEGNLLVSDKEPGPELELALFSQRLWAELAAEPGLGAAFEYEAKGGLVVASAPEGLA
                     ALESFAAGQRAAGVEAVTVTEQQLPDLEPHLAPASAGGVYYPQDAQVMPTLAAAHVVRA
                     SGARLLTGRTVTEVLRSPDGAVRGVRTNRGDVHSPAVVNAAGTWGGDLAALAGVTLPVL
                     PRRGFVLVTEPLPPLVRHKVYAADYVADVASDSAALQTSPVVEGTAAGPVLIGASRERV
                     GFDRSFSLPVVRALAAGATALFPFLERVRAMRTYVGFRPYMPDHLPAIGPDPRVPGLFH
                     ACGHEGAGIGLATGTGQLIAQAIGGGTPDLDLKPFRPDRFDAYEDEDEGNTT"
     misc_feature    7981..7997
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 15.48"
                     /tool="antismash"
     misc_feature    7985..7995
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 17.67"
                     /tool="antismash"
     gene            8099..9124
                     /locus_tag="F9278_RS40990"
                     /old_locus_tag="F9278_41010"
     CDS             8099..9124
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1226: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015662002.1"
                     /locus_tag="F9278_RS40990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F9278_41010"
                     /product="formylglycine-generating enzyme family protein"
                     /protein_id="WP_152172840.1"
                     /transl_table=11
                     /translation="MAHDKPCCAPGPEPVAEPVTGAEVGPPAGPVGGPVDVPSRVPSRV
                     PSGVPSGAAVSWGGEPLLSLPGGEFLMGTEDEAGYPADGEGPVREVGVSPFRIAATTVT
                     NERFGAFVAATGHVTESELFDFSFVFEGFLPADLRAVSPRVPGTPWWRGVRGASWRQPE
                     GPGSSVDAIPDHPVVHVSWNDARAYCAWSGTRLPTEAEWEYAARGGLEGKRYPWGDELA
                     PGGRHVCNIWRGTFPTDNTAADGYRATAPADAFEPNGFGLYNTVGNVWEWCADRFSPDF
                     HATGPRTDPTGPPDGTARVMRGGSHLCHASYCNRYRVAARSSNTPDSAAGNIGFRVVAA
                     V"
     gene            complement(9207..9503)
                     /locus_tag="F9278_RS40995"
                     /old_locus_tag="F9278_41015"
     CDS             complement(9207..9503)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="F9278_RS40995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="F9278_41015"
                     /product="hypothetical protein"
                     /protein_id="WP_152172841.1"
                     /transl_table=11
                     /translation="MRVVRGRGITPAREENLWKPAETRVVGGTIKPLTAEKVAEAIVKG
                     IEQGRFTICPDTGTRALVRLGSVLMPLPKREFDRRVRAVQRSTRPVRRSTPGA"
     gene            9590..11437
                     /locus_tag="F9278_RS41000"
                     /old_locus_tag="F9278_41020"
     CDS             9590..11437
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009323336.1"
                     /locus_tag="F9278_RS41000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F9278_41020"
                     /product="glycoside hydrolase family 15 protein"
                     /protein_id="WP_152172842.1"
                     /transl_table=11
                     /translation="MPGQPSRIEDYALIGDLLTAALVGKDGSIDWLCLPRFDSPACFAA
                     LLGDEDNGRWRIAPADENGPYSQRRYRDDTAILETEWETTRGQVLVTDFMPCRKTGAPS
                     LVRIVEGISGTVDMRMDLRLRFDYGRVLPWMRRRGGALTGTAGPESVWLRTPVRPVAHG
                     TAHTAVFPVTAGERIPFVLTWHPSHLAAPRPLDAFEALRSTETYWRRWLRRLTYDGPYR
                     DAVARSLITLKALTYQPTGGIVAAPTTSLPEEIGGVRNWDYRFCWLRDAGMTLEALLRS
                     GFKAEADAWRGWLERAVAGRPEDVQIMYGIAGERRLTEWEADWLPGYEGSRPVRIGNAA
                     AAQRQLDVPGEVMDAIHLAIGCGLRPRKHLASLQAVFLEHLEQVWSEPDQGLWEMRGAP
                     RHYTHSKVMCWVAFDRAVKLAESHARPGWVERWREVRDRIHRDICEKAYDPERNTFTQS
                     YGSPELDAALLQIPQTGFLPADDPRVIGTIEAVERELLQDGLVARYSVGTADSPDGLTG
                     GEGAFLACSFWLADALRLIGREDDARALYERLLELRNDVGLLSEEYDPRARRQLGNFPQ
                     AFTHVPLIRVAYELDRHALDARREDPKAPPGGPSGAKEG"
     gene            11441..11911
                     /locus_tag="F9278_RS41005"
                     /old_locus_tag="F9278_41025"
     CDS             11441..11911
                     /GO_function="GO:0005267 - potassium channel activity
                     [Evidence IEA]"
                     /GO_process="GO:0034220 - monoatomic ion transmembrane
                     transport [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005484536.1"
                     /locus_tag="F9278_RS41005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F9278_41025"
                     /product="potassium channel family protein"
                     /protein_id="WP_152172843.1"
                     /transl_table=11
                     /translation="MLPGFFTRAVELLLGRDGKGRPLHLQAAGAATAVLVVVMLLGSWA
                     VIVAEHGAPRANLTSYPKALWWSVETATTVGYGDFFPVTLWGRVVGAVVMVVGITTYGM
                     VTAALATWFVGREQKRHELTHRAHELCDETAHALHERFDRLERMLGAKGDGD"
     misc_feature    11445..11460
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.95"
                     /tool="antismash"
     misc_feature    12457..12476
                     /note="TFBS match to DosR, Hypoxia stress response
                     regulator, confidence: weak, score: 23.59"
                     /tool="antismash"
ORIGIN
        1 cggtcggttt gatgggggcg cggggtgatc cgtgccgtca cgggtcgacg accgcgggcc
       61 cacgacaccc gacacgcgcc ggagatgagc tgcgatggtg accgaccggt acggcaaccg
      121 cctgcacgag tgcaccgccg aaggggcggg acacctggac cgggcagtgg aggggctgtt
      181 gttcttccgg cccgacttcc cgaccgccgt cgcggacgcg gtggccgcgt gccccacctc
      241 gccgatggca caggcgttct ccgcctatct gggcgtgctc ggcaccgagt cccgggacgc
      301 cgccgaggcg cgccgccggt tcacggagtt cggcgccggg ctggaccact cggcgctgcc
      361 ccggcgggag cggatgcaca tggcggcggc cgaggcctgg ctcgggggcg atctgggccg
      421 ggccgggcag gtactggagg agctggtcgt ggagtgcccg cgtgatccgt tggccctggc
      481 cgtgggccat cagctcgact tcttcaccgg cgacgcgaca cggctgcggg accggatcgg
      541 cggtgccctg ccctcgtggg acgaggacga cccccatcgc ggtccgctgc tgggcatgta
      601 cgccttcggt ctggaggagt cggggcacta cggccgcgcc caggaggtgg ctcgggccgc
      661 cgtcgaacgc aacgcccatg acatctgggc catccacgcg gtcgtccatg tgcacgagat
      721 gcaggggcgg ttcgccgagg gcatcgactt cctcgacgca cggctcgacg gctgggcgag
      781 cggcagtctg ctgacggtgc acagctggtg gcactacgcc ctgtacgcgc tggaggcggg
      841 cgacaccggc acggccctgc gggtctacga cgccgtactg caccacaagg actcgtccgg
      901 gttcgtcatg gaactcctcg acgcggcctc gctgttgtgg cggttcctcc tggacggctc
      961 ggaccaggac gcccgttggc aggccctggc cgacgcgtgg gccgcgcgcg aggatccgcc
     1021 gttctacgcc ttcaacgacg cgcacgccgt gatggccttc gcgggagcgg ggcggctgga
     1081 cacggcggac gagttcgtcg ccgaccggcg gcgctggctg acggaggccc ggcggggcgg
     1141 gccctccggg ggcgacacca accgtgtgat gaccggggag atcggcctgc cggtgtgcga
     1201 ggcgctggtg gcgtacgccc gtgaggacta cgcggcggtg gtggacctgc tctggcccgt
     1261 ccgccgccgg ctgcacacct tcggcggcag ccacgcccag cgggacgtga tccagcggac
     1321 cctgctggag gcgaccctcc gcgcccgccg ggacgacctg gcccggctgc tgctcggtga
     1381 acgcaccggt ctgagccccc acagccccta caactggctc gggcaggccc ggctcgcgga
     1441 cgccctcggc gaagcgggcc gcgcggccgt cgcccgcgac acggcgaccg aactggcggc
     1501 acccgcggcc cagcggctga gccgcaaccc gcacgacacg tatctcgtac ggaggccctg
     1561 atccccggcc tgaagcaccc gccccggccc gaggaacccg ccccggccgg gattcgcgga
     1621 ccaggccgtc gcgcgacccg cggacccggc cgtcacgacc cgctcccggc taggacaggc
     1681 agcccacgtg ggccagggcc tgcttcagca ggactccctg gccgcccggc atctcgctct
     1741 ggaccgactc cgacgccgcg tcctgggggc tgaaccacac caggtcgagc gcgtcctgcc
     1801 gggggcggca gtcgccggcc acggggacga tgtaggcgag cgacaccgcg tgctgacgcg
     1861 ggtcgtggaa cggggtgatg ccctgcgtcg ggaagtactc ggcgacggtg aagggctgca
     1921 gcgcggacgg gacgcgcggc agcgccaccg gaccgaggtc cttctccaga tgacgcagca
     1981 gcgcgtcccg tacccgctcg tggtgcatca cgcggccgga gaccagattg cggctgaccg
     2041 tcccgtccgg gccgatgcgc agcagcagcc cgatgctggt gacttcgccg ctgtcgtcga
     2101 cgcgcacggg cacggcctcg acatacagga tcggcatccg ggcgcgcgcc gactcgagct
     2161 cgtcggacgg cagccagccg ggcgtggttt cggtcatgtc agacattggc cgatcatact
     2221 ttcaacgtca gccggagcgc gcgtcgctcc gatcacacct gtcagagatg ccccggccgc
     2281 cccgcccgca tgcgcggcgc cgacgatcag tcgtgcgcgg cccacattcc gcgcacatga
     2341 ccgagatggc gggtcatcac cgtgtgtacg gcggcctcgt cgcgggccag gagggcgtcc
     2401 aggagttcca ggtgctcctg cgccgaggac agcagccggc ccgactcggc gagcgcggtc
     2461 agaccgtaga gccgggcgcg tttgcgcagg tcaccgacga cctcgacgag atgtgcgttg
     2521 cccgctaggg cgagcagtcc gagatggaag cgggtgtcgg cctcgacgta cgcgacgagg
     2581 tccccggcgg cggcagcggc gacgatctcc cgggcggccg gccgcagcgc ctccagggag
     2641 accgggtcgg cggtccgggc caggccgacc gtggtcggga tctcgatgag cgcgcggaca
     2701 tgggtgtact cgtcgagctg tttctcggtg acgacggtga cccggaaccc cttgttgggc
     2761 acggtgtcca ccaggccctc cttggccaga tccagcatgg cctcccgcac cggtgtcgcc
     2821 gagacaccga agcgggtggc gagccccggg gcggagtaca cctcgcccgg ccgcagttca
     2881 ccggcgatca gcgcggcccg cagcgcgtcg gcgacccgtt cgcggtagct gctcttcttg
     2941 ccgccgagca ccggcagggc gggaccggcg gcaggggctg acggggccat ggcacctctc
     3001 ctagagaacg aacccggacg ggaacgggtc ggtcgggtcg agcagatact gcgccgtgcc
     3061 cgtgatccag gcgcggccgg tgaagcttgg cagcacggcg ggcaccccgg ccacctcggt
     3121 ctcgccgagc agtctgccgg tgaagtgggt accgatgaac gactcgttca cgaactcggt
     3181 gtgcagcggg agttcacccc gggcgtgcag ttgtgccatg cgcgcgctgg tgcccgtacc
     3241 gcagggggag cggtcgaacc agccggggtg gatggccatg gcgtggcggg agtgccgggc
     3301 ggtggcgccg ggggcgtaca gatggacgtg gtggacgccg tggatcgacg ggtcctccgg
     3361 atggacgggc tcctcctccg cgttgatggc gtccatcagc gcgagaccgg ccttgaggat
     3421 gtcgtccttg cggtcgcggt cgaagggcag cccgaactgc tccagcggca ggattgcgta
     3481 gaaattgccg ccgtacgcga ggtcgtaggt caccgtccgc ccgtcggcga gcgtggcctt
     3541 gcgatcgagg ccgacggaga acgacggcac gttccgcagg gtgaccgccc gcgccgcgcc
     3601 gtcctccacc gcgacctcgg ccacgacgag acccgccggg gtgtccaggc ggatggtggt
     3661 gaccggttcg acgacctcga ccatgccggt ctccacgagc acggtcgcca cgccgatcgt
     3721 gccgtggccg cacatgggta gatagccgga gacctcgatg tagaccacgc cgtagtcgca
     3781 gtcggggcgg gtcggcggct gcaggatcgc gccgctcatc gccgcgtgcc cgcgtggctc
     3841 gttcatcagc aactgcttga cgtcgtcgcg gtgttcacgg aaccacagcc ggcgttcgtt
     3901 catggtggcg ccggggatcg tgccgatccc gccggtgatc acccgggtgg gcatgccctc
     3961 ggtgtgcgag tcgacggcgt gcaggacgag tgtgctgcgc atgaaccgct ctccctccgg
     4021 tgtgagttac gcgagtcccg cggccacggc cttctcggtg gccgcccgga tcacggcctc
     4081 ctgctccggc agcagctcca cgcgcggcgg acggcagcga cctccgtggc gccccacgat
     4141 gtccatcgac aacttgatcg cctgcacgaa ctcgaccttc gagtcccagc gcagcagcgg
     4201 gtgcagctgt gcgtagagcg ccttcgccgt cgcgagatca ccgtccaccg ccgcgtggta
     4261 cagctcgacg gtcgcggcgg gcagcgcgtt cggataaccg gccacccagc ctttcgcacc
     4321 cgcgagcgcc agctccagca ggacgtcgtc ggcgccgatc aacaggtcaa gttccggggc
     4381 gagttcggcg agctggtacg cccggcggac atcgccggag aactccttca cggcccggat
     4441 gcacccctcg ccgtgcagct tggcaagcag ttcggggacc aggtcgacct tggtgtcgat
     4501 cgggttgttg tacgcgacga ccgggacgcc cgccttcgcg acctcggcgt agtgcgcgag
     4561 caccgagcgc tcgtcggcgc ggtacgcgtt cggcggcagc agcatcaccg aggcgcagcc
     4621 cgcgtcccgc gcctgctcgg cccagcgccg ggactcggcg gacccgtacg cggcgacgcc
     4681 cggcatcaca cgcgagccgc cgatcgcggc gacggccgtc tcgacgacct tggcgcgctc
     4741 ctcgggcgtc agcacctggt actcgccgag cgagccgttc gggacgacac cgtcacagcc
     4801 gttctcgacc agccaggcgc agtgctcggc gtacttgtcg tggtcgaccg agagatcgtc
     4861 gcggaggggg agcgcggtgg cgacgaggac gccgcgccag gggtggtggt tcgggctgcc
     4921 ggtcatatcg ggttccctct cgatggggtg tgacatatca ctgagtcctg tggtggtgac
     4981 gggctgccgg tgaagcggtt ctaccggtcg tcatcgtcct gctcgctctc tcccgtccgg
     5041 acctctcccg tccggacctc tcccgtccgg acctctcccg tccgggccag cacgcccagc
     5101 ggcacgggct gggcgaacgg ccgccgggcc acggcctgtt cgcacccggc gatccccgcg
     5161 accgcgggtc cgcacatccg gccctggcac cagcccatcc cggcacgggt gagcagcttc
     5221 accgtgcgga cgtccccggc tcccagctcc ccgacggcct cgcggacggc cccggcggtg
     5281 acctcctcgc accggcagac gaccgtgtcg tcccggacct gctcggtcca gtgcgccggc
     5341 ggaacgtaca cggtgtcgag cgcctcgaag aaccgcctta gttccgcacg ggactcggcg
     5401 gcccccgccc atgtgcccgg gtccggcacc cacccccgca gacgggcggc ggccgaccgt
     5461 ccggcgatgt gcccctcggc cagggagagg gccgcgccgc cgatgccggt ggtctcgccc
     5521 gccgcccaga cacccggcac gtccgtgcgc tgctccccgt cgacccacac gcgctgcccg
     5581 ggggactcga cccggcagcc gagcgtctcg gcgaggtcgg tgtgcggcag catgccgtgc
     5641 ccgacggcga gcgtgtcgca ggggattcgc cgctcgctgc cgggccgcac ccgcccctcg
     5701 gcgtcgagcg cggcgacggt cacggcctcc agccggtcgg cgccgtgcgc ctcgacgacg
     5761 gtgtgccgga cgagggtccg tacccggcgg cgcagcaact ccaccgcgta cccggcccct
     5821 tcggcgagct tgtccgcccg gccggccagt gctccggccc gtcgcgccag ggccctcggg
     5881 ccggtggact ccaccagcgc ggccaccgtg acgcccgccg ccgcgagccc ggtcgccacc
     5941 ggcagcagca ggggtccggt cccggcgacg accgccgtgc ggccggacac caccagcccg
     6001 cccttcagca tggcctgcgc gcccccggcg ctgaccacac cgggcagggt ccagccgggg
     6061 aagggcagca ccttctcgta gccgccggtc gcgagcagga cggcgtccgc gcgtacctcg
     6121 gcgggcgtct cctggccggg cccgagcagg gcgtggacgg tgaggcgcgc ggggccgccg
     6181 tcaatgccgc cgccctcggg gcggcgttcc acgcaccaga catggtggtc cgggagatgg
     6241 gtgacgtgcc cggcgtcgat ctggcgccgg aggccgtcgc gcagccgccg ccaggtgcgc
     6301 cactggtggt gcagggcccc cgggcgccgc gccccgagcc cggccgcggg ctgccggtag
     6361 aactgtccgc cgggtgcccg cgcggcatcg accaccgtga cccgtacgcc ctccccggcc
     6421 gccgccaggg ccgccgcgag gcctgcggga ccggcgccga tgatcgccag atggggtggc
     6481 ccgggggcat gggagcgggt ggggtcagtg ctcatggccc gtgccctcct gggtgcggat
     6541 cgcgtcgccc ggccggagcg ggatcagaca agcccgttga ttggggcggt cgttgacggt
     6601 gatcaggcag tcgaagcaca cgccgatgcc acagaagatc ccgcgcggcc ggccctcgcc
     6661 ccgggtgctg cgccaggatg tgaccccggc ggcccagagc gcggcggcga ccgtctggcc
     6721 gggcagcgca tccagttgac ggccgtcgag ggtgacggtg aaggcgggcc ccggctcggc
     6781 ccgcgccaac tccattggtt tcacgtcgtg ttcccctcgt cctcgtcctc gtacgcgtcg
     6841 aaccggtccg ggcggaacgg cttgaggtcc aggtcgggtg tcccgccccc gatggcctgg
     6901 gcgatcaact gcccggtgcc ggtggcgagt ccgatcccgg cgccctcgtg gccgcaggcg
     6961 tggaacaggc ccgggacacg ggggtcgggg ccgatggcgg gcagatggtc cggcatgtac
     7021 ggccggaagc cgacatacgt ccgcatcgcc cgcacccgct ccaggaacgg gaacagcgcg
     7081 gtcgcgcccg ccgccagcgc ccgtacgacg ggcagcgaga acgaccggtc gaagccgacc
     7141 cgttcgcggc tcgcgccgat cagtaccggc ccggcggccg tgccctcgac gaccggggag
     7201 gtctgcagtg ccgccgagtc gctggccacg tcggccacgt agtcggcggc gtacaccttg
     7261 tgccgcacca gcggtggcag cggttcggtg accaggacga agccgcgccg cgggaggacg
     7321 ggcagggtga ctccggcgag cgcggccagg tcgccgcccc aggttccggc ggcgttcacg
     7381 acggccgggc tgtgcacgtc accccggttg gtccgtacgc cgcgtacggc accgtccggt
     7441 gagcgcagca cctcggtcac ggtccggccg gtgagcagcc gggcgccgga ggcccgtacg
     7501 acatgggcgg cggccagggt gggcatgacc tgggcgtcct gcgggtagta cacgccgccc
     7561 gccgacgcgg gagccaagtg tggttccaga tccgggagtt gctgttcggt gacggtcacc
     7621 gcctcgaccc cggcggcgcg ttgcccggcc gcgaacgact ccagcgcggc gaggccctcc
     7681 ggtgcggagg cgacgacgag gccgcccttc gcctcgtact cgaacgccgc gcccaggccc
     7741 ggctcggcgg ccagctccgc ccacaaacgc tgggagaaca gggcgagttc cagctcgggg
     7801 ccgggttcct tgtcggagac cagcagattg ccctcgccgg cgccggtcgt gccgccggcc
     7861 accgggccac ggtccaccac gacgacgctc aggcccgctc gggccgcgta cagggcgcag
     7921 gccgcgccca ccattcccgc tccgacaacc acgacgtcgc aggtcagtcg ctcggtcacg
     7981 gcagtactat gtcacatggc gctgtgtcgt ggaatacccc gagcgggctc ggggcgaggc
     8041 gcggactacg ctgcgggccg tacccccgac accccgctcc ccggccgagg acaccgcgat
     8101 ggcacacgac aagccctgct gcgcccccgg acccgagccg gtggccgagc cggtgacagg
     8161 ggctgaggtc gggccgccgg ccgggccggt cggtggtccc gtcgacgttc cgtcccgagt
     8221 tccgtcccga gttccgtccg gtgttccgtc cggcgcggcg gtgtcgtggg gtggtgagcc
     8281 gctgctgtcg ttgcccggcg gggagtttct gatgggcacc gaggacgagg ccggttatcc
     8341 ggcggacggt gagggtccgg tccgggaggt cggggtgagc ccgttccgta tcgccgcgac
     8401 gaccgtgacc aatgagcggt tcggggcgtt cgtggccgcg accgggcatg tgacggagtc
     8461 cgaactcttc gacttctcct tcgtcttcga ggggttcctg ccggccgacc tgcgtgccgt
     8521 ctcgccgcgc gttcccggca ccccgtggtg gcgcggcgtc cggggtgcca gctggcggca
     8581 gccggaagga cccgggtcct ccgtggacgc gatccccgac caccccgtgg tgcacgtctc
     8641 ctggaacgac gcgcgggcct actgcgcctg gtcgggcacc cggctgccca cggaggccga
     8701 gtgggagtac gcggcccgtg gtggcctgga ggggaagcgc tacccgtggg gcgacgaact
     8761 cgcccccggc ggccggcacg tctgcaacat ctggcgcggc acgttcccga ccgacaacac
     8821 cgccgccgac gggtaccgtg ccacggcccc ggcggacgcc ttcgagccca acggcttcgg
     8881 cctgtacaac accgtcggca atgtgtggga gtggtgcgcc gaccggttca gcccggactt
     8941 ccatgccacc ggcccgcgta cggatccgac gggcccgccc gacggcacgg cccgggtgat
     9001 gcgcggcggc tcccacctgt gccacgcctc ctactgcaac cgctaccggg tggccgcgcg
     9061 ctcctccaac accccggaca gcgcggcggg gaacatcggc ttccgggtgg tggcggcggt
     9121 ctgaagggcg gccccgttcg aatgcccggc cccagccgga tgcctggcct cggtccgatg
     9181 cccggcccca gccggatgtc gggcactcag gcgcccggcg tggaccgccg gaccggtctc
     9241 gtcgaccgtt ggaccgccct gacccggcgg tcgaactcgc gcttgggcag cggcatcagc
     9301 acgctgccca agcggaccag ggcccgggtg cccgtgtccg ggcagatcgt gaagcgcccc
     9361 tgttcgatgc ccttcacgat cgcctccgcg accttctccg ccgtgagggg cttgatcgtg
     9421 ccgccgacca cacgggtctc cgccggcttc cagaggttct cctcgcgcgc gggtgtgatg
     9481 ccccggccac gtaccacccg cacccgacga cccaccgaag cccccacggc gagaactcga
     9541 acgccccact cggcatgccc acaacggaca accccctgac actgacccca tgccaggaca
     9601 gcccagccgc atcgaggact acgccctcat cggcgacctc ctcaccgccg ccctcgtagg
     9661 caaggacggc agcatcgact ggctctgcct cccccgtttc gactcacccg cctgcttcgc
     9721 cgccctcctc ggcgacgagg acaacggccg ctggcgcatc gccccggcgg acgagaacgg
     9781 cccgtactcc cagcgccgct accgcgacga cacggcgatc ctggagacgg agtgggagac
     9841 gacccgcggc caggtcctgg tcaccgactt catgccgtgc cgcaagaccg gcgcccccag
     9901 cctcgtacgc atcgtcgaag gcatctccgg caccgtcgac atgcgcatgg acctgcggct
     9961 ccgcttcgac tacggccggg tcctgccctg gatgcggcgg cgcggcgggg cgctgacggg
    10021 caccgcgggc cccgagtcgg tctggctgcg cacccccgta cggccggtcg cccacggcac
    10081 cgcccacacc gccgtcttcc cggtcaccgc cggcgaacgg atccccttcg tcctgacctg
    10141 gcacccctcc catctggccg ccccccgccc cctggacgcc ttcgaggcac tgcgcagcac
    10201 cgagacgtac tggcgccgct ggctgcgcag actgacgtac gacgggccgt accgggacgc
    10261 cgtcgcccgc tccctgatca cgctcaaggc gctgacgtac cagccgaccg gcgggatcgt
    10321 cgccgcgccg accacgtccc tgccggagga gatcggcggc gtgcggaact gggactaccg
    10381 gttctgctgg ctgcgggacg cgggcatgac gctggaggcg ttgctgcgca gcggcttcaa
    10441 ggccgaggcg gacgcctggc ggggctggct ggagcgggcg gtggcggggc gccccgagga
    10501 cgtgcagatc atgtacggca tcgcggggga gcggcggctc accgagtggg aggccgactg
    10561 gctgccgggg tacgaggggt cgcgcccggt acggatcggc aacgcggctg ccgcgcaacg
    10621 gcagttggac gtacccggtg aggtgatgga cgccatccat ctggccatcg gctgcggtct
    10681 gcgcccccgc aagcatctgg cctcgctgca ggcggtgttc ctggaacacc tggagcaggt
    10741 gtggtccgag cccgaccagg ggctgtggga gatgcgcggc gccccccgcc actacacgca
    10801 ctccaaggtg atgtgctggg tggccttcga ccgggcggtc aagctggccg agtcgcacgc
    10861 ccggccgggc tgggtggagc ggtggcgcga ggtccgcgac cgtatccacc gcgacatctg
    10921 cgagaaggcc tacgacccgg agcggaacac cttcacccag tcgtacggct ccccggaact
    10981 cgacgccgcg ctgctgcaga tcccgcagac cgggttcctg ccggcggacg acccgcgggt
    11041 gatcggcacc atcgaggccg tcgagcgtga actcctccag gacgggctgg tggcccgcta
    11101 ctcggtgggc accgccgact cgccggacgg cctcaccggc ggcgagggtg ccttcctcgc
    11161 ctgctcgttc tggctggcgg acgccctgcg gctgatcggc cgcgaggacg atgcccgcgc
    11221 cctgtacgaa cggctgctgg agctgcgcaa cgacgtgggc ctgctctccg aggagtacga
    11281 cccccgcgcc cgccgccaac tgggcaattt cccccaggcg ttcacccatg tcccgctgat
    11341 ccgggtcgcc tacgaactcg accggcacgc cctggacgcc cgccgtgagg accccaaggc
    11401 gccgcccggc gggccctccg gcgcgaagga ggggtgagcg gtgcttcccg ggttcttcac
    11461 cagggccgtc gagctgctgc tcggccggga cggcaagggc cgccccctcc atctgcaggc
    11521 ggcgggcgcc gccaccgccg tgctggtcgt ggtgatgctg ctcggctcct gggccgtgat
    11581 cgtcgccgag cacggcgcgc cgcgcgccaa tctcacctcg tacccgaagg ctttgtggtg
    11641 gtccgtcgag acggccacga ccgtcggcta cggcgacttc ttcccggtga cgctctgggg
    11701 ccgggtcgtc ggcgcggtcg tcatggtcgt cggcatcacc acgtacggca tggtcaccgc
    11761 cgccctcgcc acctggttcg tgggccggga gcagaagcgg catgaactga cccaccgggc
    11821 acatgagttg tgcgacgaga ccgcgcacgc cctgcacgag cggttcgacc ggctggagcg
    11881 gatgctcggc gccaaggggg acggcgactg accgccgacg cccgaagccg cgtgggtcac
    11941 ccccgacccg atgtccaccc ctcggacggc gggaccattt cgcggacacc ctcttgacgc
    12001 acggcgtggt cggctcgaca ctccaggtgg ggtatttcct agtgaacagg tagggaatga
    12061 tggggcgcct gaagccggtg atcactcgtg tgccgctcag gcgccggccg tccctctttc
    12121 tgacctcccg ccgtcacatc gatctgctgc gtgtctgcgg cgcgggaagc cccctggcct
    12181 gagccgtcgg cgtcgcgcgc caccgcgccc tcgcccctcg tgtactcgcg tcaccacgcg
    12241 accgcgcacc agatcccccg gggagacaca tgtccgccat gcccgtccac gccctgaacg
    12301 ccgttccgtc gccgcgcccc ctgccctcct tccggggcag gatcggctgc gacgcgcgca
    12361 gcggccacta cgccgtgccg cgccgctacc ggctccatct gtcgctgtcc tgtccgggcg
    12421 ccctgcgcat cgccgtcgtc cacagcctcc tcgggctggc ggacgtctgc cccgtgaccc
    12481 tcctgcccgc cgtgcccgac ggcccgaacg gcgagcaccc cgcgctgcgc ccgctgtacg
    12541 aggcgagcgc ccaccgctac cccggggcgg ccgtggcgcc cgtcctcagc gacgactggt
    12601 ccggacggat cgtcagcact cacgcccccg acatcatgcg cgacctcgcc cggcgcttcg
    12661 gcggcagccg gcccgagctg tacccggcgg gcgcggaggc cgagatcgag ggcgtcacgc
    12721 gcctgtgcga gcagggcatg gacggcaccg cccagcgcgc cggacgcgcc gacgccgacg
    12781 atccggaacg ccgtgacgcg ctcggctccc tgctgcgcac cctgcgctcc ctggacgccc
    12841 ggctcgccgg acagcggcac atcctcggcg acgaactcac cgccgcagac gtcgagttgt
    12901 gggtcgccct ggtgcggctc gacaccgtgc accgctggca cctggacgcc tccgccgtgc
    12961 accgcgtcgc cgaccaccc
//
