LOCUS       NZ_CP045096            11344 bp    DNA     linear   CON 20-NOV-2024
DEFINITION  Streptomyces phaeolivaceus strain GY16 chromosome, complete genome.
ACCESSION   NZ_CP045096
VERSION     NZ_CP045096.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces phaeolivaceus
  ORGANISM  Streptomyces phaeolivaceus
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 10116136)
  AUTHORS   Mo,P.
  TITLE     Streptomyces sp. strain GY16 isolated from leaves of Broussonetia
            papyrifera
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 10116136)
  AUTHORS   Mo,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-OCT-2019) College of Life Science and Technology,
            Central South University of Forestry and Technology, No. 498,
            Shaoshan South Road, Changsha, Hunan 410004, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 15-AUG-2019
            Assembly Method                   :: HGAP v. v. 1.3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 120.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_009184865.1-RS_2024_11_18
            Annotation Date                   :: 11/18/2024 02:51:11
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,113
            CDSs (total)                      :: 9,024
            Genes (coding)                    :: 8,642
            CDSs (with protein)               :: 8,642
            Genes (RNA)                       :: 89
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 382
            CDSs (without protein)            :: 382
            Pseudo Genes (ambiguous residues) :: 0 of 382
            Pseudo Genes (frameshifted)       :: 112 of 382
            Pseudo Genes (incomplete)         :: 305 of 382
            Pseudo Genes (internal stop)      :: 23 of 382
            Pseudo Genes (multiple problems)  :: 53 of 382
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:44:39
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 8224047
            Orig. end                         :: 8235391
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP045096.1.
            Bacteria and source DNA available from Yunlin Zhao.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..11344
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="25"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11344
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11344
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6344](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..6344)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            639..1370
                     /gene="hemQ"
                     /locus_tag="F9278_RS37665"
                     /old_locus_tag="F9278_37685"
     CDS             639..1370
                     /EC_number="1.3.98.5"
                     /codon_start=1
                     /gene="hemQ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018564417.1"
                     /locus_tag="F9278_RS37665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F9278_37685"
                     /product="hydrogen peroxide-dependent heme synthase"
                     /protein_id="WP_152172289.1"
                     /transl_table=11
                     /translation="MSDVAPTPESGRIPNKGKLAKDLNEVIRYTLWSVFKLKDVLPEDR
                     SGFADEVQELFDQLAAKDVTVRGTYDVSGLRADADLMIWWHAETADQLQEAYNLFRRTR
                     LGRALEPVWSNMALHRPAEFNRSHIPAFLADETPRDYVSVYPFVRSYDWYLLPDEDRRR
                     MLADHGKMARGYPDVRANTVASFSLGDYEWLLAFEADELYRIVDLMRHLRASEARMHVR
                     EEVPFYTGRRKSVADLVAGLA"
     gene            complement(1376..2929)
                     /locus_tag="F9278_RS37670"
                     /old_locus_tag="F9278_37690"
     CDS             complement(1376..2929)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (94-470). E-value:
                     1.8e-23. Score: 75.4. Matches aSDomain:
                     nrpspksdomains_F9278_RS37670_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016824197.1"
                     /locus_tag="F9278_RS37670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F9278_37690"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_152172290.1"
                     /sec_met_domain="PF00561 (E-value: 3.2e-26, bitscore: 91.5,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRTAVLYGAVGALLLSGLAAAPAAPAAPAAPTAVEGIRFGKCPAV
                     EGLPDEVRCGTVEVPLDHARPDGRRITLTVSRIRAKGKDAQGRKVARQGALVFNPGGPG
                     ASGMFYPLIGHLPEWKRIGAAYDLVGYAPRGVGRSAPLSCEDPEKLHRGPSTAPTHPSE
                     AYKKERIARAKAYARGCAQRGGSALRHYHSLNNARDLDVLRAALGEPRLTFMGASYGTY
                     FGALYAALFPSHVRRMVFDSAVNPDPEQIWYRNNLDQSAAFEGRWADFRAWIARHHKVY
                     GLGDTPEKVLRSYERAAARLTLKPADGKVGPGQLRGAFLQAAYYDDHWPQRALALSAYL
                     KGDPEPLVQIAGPYPEAAVEQENTKAVYTAVECNDGPWPTRWRTWDRDNTRLARTAPFE
                     TWDNVWTNLPCAYWDGPRQRPLDVRTGPGELPPTLILAAERDAATPYDGAIELHRRLWG
                     SVLVTERDAGNHGVSGGTNRCVNGYLEAYLLEGRLPERRAACAARPEPNTAPLGSKGRG
                     "
     aSDomain        complement(1520..2647)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_F9278_RS37670_Abhydrolase_1.1"
                     /evalue="1.80E-23"
                     /label="F9278_RS37670_Abhydrolase_1.1"
                     /locus_tag="F9278_RS37670"
                     /protein_end="470"
                     /protein_start="94"
                     /score="75.4"
                     /tool="antismash"
                     /translation="ALVFNPGGPGASGMFYPLIGHLPEWKRIGAAYDLVGYAPRGVGRS
                     APLSCEDPEKLHRGPSTAPTHPSEAYKKERIARAKAYARGCAQRGGSALRHYHSLNNAR
                     DLDVLRAALGEPRLTFMGASYGTYFGALYAALFPSHVRRMVFDSAVNPDPEQIWYRNNL
                     DQSAAFEGRWADFRAWIARHHKVYGLGDTPEKVLRSYERAAARLTLKPADGKVGPGQLR
                     GAFLQAAYYDDHWPQRALALSAYLKGDPEPLVQIAGPYPEAAVEQENTKAVYTAVECND
                     GPWPTRWRTWDRDNTRLARTAPFETWDNVWTNLPCAYWDGPRQRPLDVRTGPGELPPTL
                     ILAAERDAATPYDGAIELHRRLWGSVLVTERDAGNH"
     gene            complement(3040..3807)
                     /locus_tag="F9278_RS37675"
                     /old_locus_tag="F9278_37695"
     CDS             complement(3040..3807)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005481893.1"
                     /locus_tag="F9278_RS37675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F9278_37695"
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_152172291.1"
                     /transl_table=11
                     /translation="MLWVLFLLLAWAAAGVSCARLCLTSLRAAAADTAVHADHAHRCHR
                     LTLYEAAFLSGGPARVADLTLVSMARQRRLLLAHTGWATVVDPDGRDEMERSVIGAIGP
                     GGQSRIAPVRRSAAAAESVRHLSDRLVAAGLAVPEAARTGVADAVTQVRGAALGVCGLG
                     ALALLLPSQGFEEQRLLIALWFALPLVLTLSCLVIARIEGPPGTRWASPEGMRVLGAVV
                     GRGGGEVADLVSVAVWGVGAMESPELRAAFEQR"
     gene            complement(3941..4750)
                     /locus_tag="F9278_RS37680"
                     /old_locus_tag="F9278_37700"
     CDS             complement(3941..4750)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005481894.1"
                     /locus_tag="F9278_RS37680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F9278_37700"
                     /product="DUF4142 domain-containing protein"
                     /protein_id="WP_152172292.1"
                     /transl_table=11
                     /translation="MRTTRARGGFFSGTGLIVAGLTATLIALVFPVWSYADRSGTGASV
                     LNATTVTTRYGALSALDRDFITKVRLAGLWELPAGQQAETKGTTEAVRVAGEHLIEGHT
                     FLDARVRDVAARLGLPLPNQPNDQQKAWLNTLTAAQGQEYDREFANILRLAHGKVFSVV
                     AQVRATTRNSLVRDLADDANTTVLDHIKVLEATGLVDYDAIARDTVSASAPPLTNSPAP
                     PVPLNDPGPPIPVTPTPLPATETPPRAEPSERYTLPPAANGPAEDGG"
     gene            complement(5001..6344)
                     /locus_tag="F9278_RS37685"
                     /old_locus_tag="F9278_37705"
     CDS             complement(5001..6344)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016824195.1"
                     /locus_tag="F9278_RS37685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F9278_37705"
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_152174366.1"
                     /sec_met_domain="DUF692 (E-value: 1.5e-97, bitscore: 325.0,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLGTGIGWRPEIADAVERMAGAAGGVDWVEVVAENVCPGHIDAS
                     LLRLRERGVTVVPHGVSLGLGGADRPDEQRLRSLAERAEALGAPLVTEHIAFVRAGGAL
                     TASPLLEAGHLLPVPRTRDALDVLCENVRIAQDALPVPLALENIAALINWPGEEMTEGQ
                     FLYDLVDRTGVRLLIDVANLHTNHVNRGEDPAKALDELPVEAIAYVHVAGGFERDGVWH
                     DSHAHPVPRQVLDVLADLASRVTPPGVLLERDDDFPEPGELEGELTAIREVLEKAEARG
                     TGATAPTAEPRAEEAEESEAAGTAEVAEPVARQRLALAQAALLSALVAGTPVPEGFDRV
                     RLGVQARALAAKRADVVGKVAPELPEILGSSYRPTFVAYAQGHPMTDGYRRDALSFAEH
                     VLLTGRPDDADTLRAVRRWWLERSGPAPLSQRPTARLARATRRVLLRR"
     misc_feature    complement(6485..6498)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 17.53"
                     /tool="antismash"
     gene            complement(6600..7406)
                     /locus_tag="F9278_RS37690"
                     /old_locus_tag="F9278_37710"
     CDS             complement(6600..7406)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005481896.1"
                     /locus_tag="F9278_RS37690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F9278_37710"
                     /product="DUF4142 domain-containing protein"
                     /protein_id="WP_152172293.1"
                     /transl_table=11
                     /translation="MRRSKGSVLVALAIAGTLTAVAYPIFYSYPNRNATAAAALTGDTV
                     TTQWGPLTPGDRDLLIRVRLAGLWELPAGQQALERSGSASVREAADHLIVGHTDLDKRS
                     RVIAAKLGVELPNQPTAEQQGWLDQMTASKTEAEYNKTWANLLRAAHGKIFPAIASVRN
                     STRNTLIRQLASDANQTVLDHITILEKTGEVDFATIADNSVSGTASPTGPPAPVPGQVP
                     PAAPPAVPSTNPDVKSTPSPFETRPVPTGRPDPEEINKDQGTAQVQ"
     misc_feature    complement(7364..7384)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 18.42"
                     /tool="antismash"
     gene            complement(7535..8143)
                     /locus_tag="F9278_RS37695"
                     /old_locus_tag="F9278_37715"
     CDS             complement(7535..8143)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005481898.1"
                     /locus_tag="F9278_RS37695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F9278_37715"
                     /product="DUF4142 domain-containing protein"
                     /protein_id="WP_152172294.1"
                     /transl_table=11
                     /translation="MPRLNGSVYASLALVVTVGALAFPMWSYADRSGTAQANMAASTVN
                     TQWGPLTASDRDLIIRVRLAGLWELPAAEKAMARSKSPEVREAADHLIVGHKDLDERVR
                     AVASQMGVELPNVPNEQQQGFLAQMDNATDEQFDRVWANLLRSAHGKIFPAIGQVRNMT
                     ENTLVRQLASDTNQTVLDHITVLEKTGQVDFDAIANGTI"
     gene            complement(8287..9042)
                     /locus_tag="F9278_RS37700"
                     /old_locus_tag="F9278_37720"
     CDS             complement(8287..9042)
                     /GO_function="GO:0004045 - aminoacyl-tRNA hydrolase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010983656.1"
                     /locus_tag="F9278_RS37700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F9278_37720"
                     /product="peptidyl-tRNA hydrolase"
                     /protein_id="WP_226967122.1"
                     /transl_table=11
                     /translation="MTTNDPAPDPTPASGPTQAQDSPFRDERTARDEAPQYVLPLVARI
                     ERAAPPARTDALETAARAVLVMLSDARSLGGGGEWAEAMRSWQDARIRKVVRRARGAEW
                     RRAEALPGITVAGKSAEVRVFPPVPLDGWPKDLARLQVSGTDLDDPEPPAGPDPAAPVL
                     WLNPEVAMSAGKAMAQAGHGAQLAWWDLDDTARAAWRDAGFPLAVRTAAPAHWRTLTTA
                     GLPVVRDAGFTEIAPGSSTVIADHRPLFG"
     gene            9113..10033
                     /locus_tag="F9278_RS47710"
     CDS             9113..10033
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009317912.1"
                     /locus_tag="F9278_RS47710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_226967123.1"
                     /transl_table=11
                     /translation="MERELLLRLEGVGRRYGFRGDWVLRDVDLEIAPSTLTRVEGANGT
                     GKSMLLRVLAGLDAPTEGRATGRPRTAYVPERFPAALPFTAAEYLTHLGAVHGLDRPAA
                     ARAAAEWLERFGAAEYARTPMGELSKGSSQKVAVAQALLAAPELLVLDEAWTGLDADAR
                     EELERAVVERTAAGAAVVFVDHDPRRLAGAPDATYAVVGGALELRPGKGDFPVSVVVEV
                     RAPSGADVPEDVRKSATLMQEMASGTHRFTVPQGESDELLRALLTARPPWHVVSVTPAP
                     AALPAPAPDPDPEPAPAPAPELESS"
     misc_feature    9125..9127
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            10033..10704
                     /locus_tag="F9278_RS47715"
     CDS             10033..10704
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005481903.1"
                     /locus_tag="F9278_RS47715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter"
                     /protein_id="WP_226967124.1"
                     /transl_table=11
                     /translation="MTALLRYQAALLVRSQRWLPPVILYAAFLGIGVQKGQPVLDSLGY
                     TAAALLPVSAWLMRICVTNEPPAARSCTGAAAGPGRAHLACVLVAFSAAALLGTAATVL
                     VTIISAPTSTDHQTRVESLPAGGAGLLAALVCALLGTAVGALTNRPLLRSRGRAVPALL
                     LGALLALVVAGSPARAAVTALVDGSRHATIPVPVLPLLAAGVLAAAATAVACALTTRRA
                     A"
     gene            complement(10710..10913)
                     /locus_tag="F9278_RS37710"
                     /old_locus_tag="F9278_37730"
     CDS             complement(10710..10913)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675663.1"
                     /locus_tag="F9278_RS37710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F9278_37730"
                     /product="hypothetical protein"
                     /protein_id="WP_404818977.1"
                     /transl_table=11
                     /translation="MSDTSDMSDYCGTEQTAAPATPVTDDGPRFAECVLCRKPTEYPES
                     HKGITLCPVCEWREAERTACSG"
     misc_feature    complement(10998..11011)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.91"
                     /tool="antismash"
ORIGIN
        1 gtcgtcgtgg ccgtccccgc cccggtcgcc gcaggcctcc tgcgcgccga gtcccccgag
       61 gccgccgccg aactgtccgc cgtcgagtac gcgtcgatgg ccctggtcac cctcgcctac
      121 cgccgcgccg acctcgccct ccccgagggc agcggcttcc tggtgccgcc ggtcgacggc
      181 cgcaccatca aggcctccac cttctcctcc cggaaatggg gctggatcgc ggaggagaac
      241 ccggacctgc tggtcctgcg cacctcggtc ggccggtacg gcgagacggc gatcctggag
      301 cacgacgaca cccacctcgt ggacgtgtcg cgcatcgacc tgcgggaggc caccggcctg
      361 accgccaccc ctctcgaaac ccgcgtcagc cgctgggacg gcggcctccc gcagtacccg
      421 gtcggccacc acgcgcgcgt ggcccgcgtc cgcgaacacg tcggcaagct gcccggcctc
      481 gcggtctgcg gagcggcgta cgacggcgtc ggcatcccgg cctgtatcgc gagcgccgcc
      541 gccgccgtcg accggatcca cggcgacccg cgcgcggtgc gcgatctcac cgcccacccg
      601 gtgcggagcc cgcacggcgg agcgggagaa taggcaccat gagcgacgtc gcccccaccc
      661 ccgagtccgg ccgcatcccg aacaagggca agctggccaa ggacctcaac gaggtcatcc
      721 gctacacgct gtggtccgtc ttcaagctga aggacgtgct cccggaggac cgctccggct
      781 tcgccgacga ggtccaggag ctgttcgacc agctcgccgc gaaggacgtg accgtgcgcg
      841 gcacgtacga cgtgtcgggc ctgcgcgccg acgccgacct catgatctgg tggcacgccg
      901 agaccgccga ccagctccag gaggcgtaca acctcttccg ccgcacgcgg ctcggccgcg
      961 cgctggagcc ggtgtggtcg aacatggcgt tgcaccggcc cgccgagttc aaccgctcgc
     1021 acatcccggc gttcctcgcc gacgagacgc cccgcgacta cgtcagcgtc taccccttcg
     1081 tacggtcgta cgactggtat ctcctccccg acgaggaccg ccgccggatg ctcgccgacc
     1141 acggcaagat ggcccggggc tacccggacg tccgcgccaa cacggtcgcc tcgttctcgc
     1201 tgggcgacta cgagtggctc ctcgccttcg aggccgacga gctgtaccgc atcgtcgacc
     1261 tcatgcgcca cctgcgcgcc tcggaggccc ggatgcacgt ccgcgaggag gtcccgttct
     1321 acacgggccg ccgcaagtcg gtggcggacc tggtggcggg cctcgcctag ctcggctacc
     1381 cgcgcccctt gcttccgagg ggcgcggtgt tcggctcggg ccgggccgcg cacgcggccc
     1441 ttcgctccgg cagccgcccc tccaacaggt aggcctccag gtacccgttg acgcaccggt
     1501 tggtcccacc cgagacgccg tggttccccg cgtcccgttc ggtgaccagc accgaacccc
     1561 acagccgccg gtgcagctcg atcgccccgt cgtagggcgt ggccgcgtcc cgctcggcgg
     1621 cgaggatcag tgtgggcggc agctcaccgg gaccggtccg gacgtcgagc ggtcgctgac
     1681 gcggcccgtc ccagtaggcg cacggcaggt tcgtccacac gttgtcccag gtctcgaagg
     1741 gcgcggtgcg cgcgagccgg gtgttgtcgc ggtcccaggt ccgccaacgc gtgggccagg
     1801 ggccgtcgtt gcactcgacg gccgtgtaga cggccttggt gttctcctgc tcgacggccg
     1861 cctccgggta cggcccggcg atctgcacga gcggctcggg gtcgcccttc agataggcgg
     1921 agagcgcgag ggcccgctgc ggccagtggt cgtcgtagta cgcggcctgg aggaacgcgc
     1981 cccgcagctg ccccgggccc acctttccgt cggcgggctt cagggtcagc cgggccgccg
     2041 cccgttcgta gctccgcagc accttctccg gggtgtcgcc cagcccgtac accttgtggt
     2101 gccgggcgat ccaggcccgg aagtccgccc agcggccctc gaacgcggcc gactggtcga
     2161 ggttgttgcg gtaccagatc tgctccgggt ccgggttcac cgccgagtcg aagaccatcc
     2221 ggcggacgtg cgaggggaac agcgccgcgt acagcgcgcc gaagtacgtg ccgtaggacg
     2281 cgcccatgaa cgtcagccgc ggttcgccga gcgcggcccg caggacgtcc agatcacggg
     2341 cgttgttgag ggagtggtag tgccgcagcg cgctcccgcc gcgctgcgcg cacccccgcg
     2401 cgtacgcctt ggcgcgggcg atccgctcct tcttgtacgc ctccgaaggg tgcgtgggtg
     2461 ccgtcgaggg cccccggtgg agcttctcgg ggtcctcgca ggacagcggt gccgagcgcc
     2521 cgacgccgcg cggggcgtac ccgacgaggt cgtacgcggc gccgatccgc ttccactccg
     2581 ggaggtggcc gatgagcgga tagaacatgc cggaggcccc ggggccgccc ggattgaaca
     2641 cgagcgcccc ctgccgggcg accttcctcc cctgggcgtc cttccccttg gccctgatcc
     2701 ggctgacggt cagggtgatc ctcctgccgt cgggccgcgc gtggtccagc ggcacctcga
     2761 cggtcccgca ccgcacctcg tccggcaggc cctccaccgc cgggcacttc ccgaaccgga
     2821 tgccctcgac ggcggtggga gcggccgggg cggcgggggc ggcgggggcg gcggcgaggc
     2881 cgctcagcaa cagtgccccg acagccccgt aaagaacggc agttcgcatg gcagtccctc
     2941 agtccctccg aagcccgaca gcgacaaaag gatggttcgt gcgataaggg gcaaaagtaa
     3001 agcaccggcc gcccgtgtgt tccgctgtcg cgcgttccgc taccgctgct cgaacgccgc
     3061 ccgcagctcg ggggactcca tcgcccccac gccccagacg gccacggaga cgaggtccgc
     3121 cacctcgccg ccgccccggc ccaccacggc tcccagcacc cgcatgccct ccggcgacgc
     3181 ccaccgggtg cccggcggtc cctcgatccg ggcgatgacg agacagctga gggtcagcac
     3241 cagcggcagc gcgaaccaca gcgcgatcag cagccgctgc tcctcgaacc cctgcgaggg
     3301 cagcagcagc gccagcgccc ccagcccgca cacgccgagc gcggcgcccc gtacctgcgt
     3361 gaccgcgtcg gccacgcccg tccgcgcggc ctccggtacg gccagccccg ccgcgacgag
     3421 ccggtcggag aggtgccgta cggattccgc cgccgcggcg gaccgtcgta cgggcgctat
     3481 ccgggactgt ccaccggggc ctatcgcgcc gatgacggac cgttccatct cgtcccgccc
     3541 gtccgggtcc acgacggtcg cccagccggt gtgggcgagc aggagcctgc gctgccgggc
     3601 catggagacg agggtgaggt cggcgacgcg cgccgggccg ccggacagga acgccgcctc
     3661 gtacagcgtg agccggtggc agcggtgggc gtggtccgcg tggacggcgg tgtcggccgc
     3721 cgccgcgcgc agcgaggtca ggcacagtcg ggcacaggac acgccggcgg cggcccaggc
     3781 caggaggagg aagaggaccc agagcatggc gtgtttctat gcgcctgccg gggccggtgg
     3841 cggccgatgt ccgtaatccg gagggaagct gcccggtctc gcccgtttgc ccactgttgc
     3901 gggccgcaat tgccaggccc cgggagcgag gggacagtgg ctaaccgccg tcctccgccg
     3961 gtccgttggc cgccggtggc agggtgtagc gctccgacgg ctcggcccgt ggcggggtct
     4021 cggtggccgg gagcggggtc ggggtcaccg ggatcggggg gccggggtcg ttcaacggga
     4081 cgggtggggc cggggagttg gtgaggggcg gggcgctcgc ggagacggtg tcgcgggcga
     4141 tcgcgtcgta gtcgacgagc ccggtggcct ccaggacctt gatgtggtcc aggacggtgg
     4201 tgttggcgtc gtcggcgaga tcgcggacca gcgagttgcg ggtggtcgcg cggacctggg
     4261 cgacgacgga gaagaccttg ccgtgcgcca ggcgcaggat gttggcgaac tcgcggtcgt
     4321 actcctggcc ctgggccgcc gtcagcgtgt tcagccacgc cttctgctgg tcgttcggct
     4381 ggttgggcag gggcaggccg aggcgcgcgg cgacatcgcg gacccgggcg tcgaggaagg
     4441 tgtgcccctc gatgagatgt tcaccggcga cccgtacggc ctcggtggtg cccttggtct
     4501 cggcctgctg tccggcgggc agttcccaca gccccgccag cctgaccttg gtgatgaagt
     4561 cccggtccag ggccgacagc gcgccgtacc gcgtcgtcac ggtggtcgcg ttgagcacgc
     4621 tcgccccggt gccggagcgg tccgcgtacg accagaccgg gaagaccagc gcgatgagcg
     4681 tcgccgtcag tccggcgacg atgagtcctg tgccactgaa gaatccccct ctggccctgg
     4741 tggttcgcat ggtgcctcct gctcgcggca ccgcacgcta atgcgctacg ggtgctgatc
     4801 ggcctaccga ctggcatgtt actgcccggt ctacgtcaac tgccgtatgc ggaggaacgg
     4861 ttgaggaggg gacaaagcac gccggacggg ggacgtggag tggtggatga atcatgtgta
     4921 aacgtggcag aaacgacggc aaacccgtgt ggggggcacg ggtttgttaa tcgcggcaca
     4981 tctgggcgtg aacccccggc tcaacggcgt agcagcaccc tgcgggtcgc tcgggccagt
     5041 cgggccgtcg ggcgctgcga gagcggcgcg ggtcccgagc gctccagcca ccaccggcgc
     5101 accgcgcgga gcgtgtccgc gtcgtccggg cggccggtga gcagcacgtg ctcggcgaag
     5161 gagagcgcgt cccgccggta gccgtcggtc atcgggtgac cctgcgcgta cgccacgaac
     5221 gtcggccggt acgacgatcc gaggatctcc ggcagctccg gtgcgacctt cccgacgacg
     5281 tccgcccgct tggccgccag cgcccgcgcc tgtacgccga gccgcacccg gtcgaagccc
     5341 tcgggcaccg gtgtccccgc gaccagcgcg gacagcaggg ccgcctgcgc gagcgcgagc
     5401 cgctgccggg cgacgggctc ggccacctcg gccgtcccgg cggcctcgga ctcctctgcc
     5461 tcctcggccc gcggctcggc ggtgggcgcc gtcgctcccg tgccgcgcgc ctcggccttc
     5521 tccaggacct cccggatcgc cgtcagctcc ccctccagct cacccggctc ggggaagtcg
     5581 tcgtcgcgct ccagcaggac gcccggcggg gtcacccggg aggccaggtc ggcgaggacg
     5641 tccaggacct gccgggggac ggggtgggcg tggctgtcgt gccagacccc gtcccgctcg
     5701 aagccgcccg cgacatggac gtacgcgatg gcctcgaccg gcagctcgtc gagcgccttc
     5761 gcggggtcct cgccccggtt gacgtggttg gtgtgcaggt tcgccacgtc gatgaggagc
     5821 cggacaccgg tgcggtccac gaggtcgtag aggaactgcc cctcggtcat ctcctcgccc
     5881 ggccagttga tcagggcggc gatgttctcc agcgcgagcg gcacgggcag cgcgtcctgg
     5941 gcgatacgga cgttctcgca cagcacgtcc agggcgtccc gggtgcgcgg caccggcagc
     6001 aggtgcccgg cctccagcag cggcgacgcg gtgagcgcgc ccccggcccg gacgaacgcg
     6061 atgtgctcgg tgaccagggg ggcgcccagg gcctccgcgc gctccgcgag ggagcgcagg
     6121 cgctgctcgt cggggcggtc ggcgccgccg agaccgaggg agaccccgtg cgggaccacc
     6181 gtgacaccgc gctcccgcag ccgcagcaac gatgcgtcga tgtgcccggg acagacgttc
     6241 tcggcgacga cctcgaccca gtcgacaccg cccgccgccc cggccatgcg ctcgacggcg
     6301 tcggcgatct ccggccgcca gccgatgccc gtccccaacg tcaccgacgt ccccgctgtc
     6361 ctcggcgtcc ccgctgtccc cgctgtcccc gctgtcctca cctgtgcgat ctgctccatc
     6421 gtcccgtccc ctcctcggtc acgtcggcca cggtctcacc aggaccctgt gtgtctcctt
     6481 acggcggacg tgtgttccgg cgtgacggag tcatggcccc ggctgccggg gccgaacccc
     6541 gtggaggtga ccttcagagc aacatttgag ctttccgtcc gggcccgcga gcccggccgc
     6601 tactggacct gcgccgtgcc ctggtccttg ttgatctcct ccgggtccgg acggccggtg
     6661 gggaccggac gggtctcgaa gggcgacggg gtcgacttca cgtccgggtt ggtggacggc
     6721 acggcgggcg gcgcggccgg cggcacctga cccgggacgg gcgccggcgg gccggtcggg
     6781 ctggcggtac cgctgaccga gttgtcggcg atcgtcgcga agtcgacctc gccggtcttc
     6841 tccaggatcg tgatgtggtc cagcacggtc tggttggcgt cggaggccag ctgacggatc
     6901 agcgtgttgc gggtggagtt ccgcaccgag gcgatcgccg ggaagatctt gccgtgcgcg
     6961 gcccgcagca ggttcgccca ggtcttgttg tactcggcct cggtcttcga ggcggtcatc
     7021 tggtccagcc agccctgctg ctcggccgtc ggctggttgg gcagctcgac gcccagcttc
     7081 gccgcgatga cccgcgaccg cttgtcgagg tcggtgtggc ccacgatcag gtggtcggcg
     7141 gcctctctga cggacgcgct gccgctgcgc tccagcgcct gctgcccggc gggcagctcc
     7201 cacagtcccg ccagccgcac acggatgagc aggtcgcggt cgccgggggt gagcggcccc
     7261 cactgcgtgg tcaccgtgtc accggtgagc gccgccgctg ccgtggcgtt gcggttgggg
     7321 tacgagtaga agatcgggta ggcgaccgcg gtgagtgtgc cggcgatcgc cagggcgacg
     7381 aggacagagc ccttcgagcg tcgcaaatga gcctcccgga ggaaaccaac tgagcgttgg
     7441 ggacggaact ttgctggagt gcgggtggtg accgctgggt gtgaccggcg ccgggcgccg
     7501 ctcgggaccg gagccgcgcc gaggccggac cgcgtcagat cgtgccgttg gcgatcgcgt
     7561 cgaagtcgac ctgtccggtc ttctccagca ccgtgatgtg gtcgagcacg gtctggttgg
     7621 tgtccgaggc cagctggcgc accagggtgt tctcggtcat gttccgtacc tgcccgatgg
     7681 ccgggaagat cttcccgtgc gcggagcgca gcaggttggc ccacacccgg tcgaactgct
     7741 cgtccgtcgc gttgtccatc tgcgcgagga agccctgctg ctgttcgttc ggcacgttcg
     7801 gcagctcgac acccatctgg gacgccacgg cccgcacccg ctcgtcgagg tccttgtggc
     7861 ccacgatcag gtggtcggcg gcctccctga cctccgggct cttcgaccgc gccatcgcct
     7921 tctcggcggc gggcagttcc cagagtccgg ccagccggac acggatgatg aggtcccggt
     7981 cggaggcggt cagcggcccc cactgggtgt tcaccgtgct ggcggccatg ttcgcctggg
     8041 cggtgcccga acgatcggcg taggaccaca tcgggaacgc cagtgcgccg acggtgacga
     8101 cgagagccag gctggcgtag accgagccgt tgagacgagg caaagtgatc ctcccggatg
     8161 atgccaactg gtcgttgggg cagttacttg gccagtaccg ggaagtacgc gcggggcggc
     8221 ggagttgttc aacaggcttt gagcgagctg agaactacga gatcaggggt gcccgcgggc
     8281 ccgctgtcag ccgaacaggg gccggtggtc ggcgatcacc gtgctggagc ccggggcgat
     8341 ctccgtgaag cccgcgtcgc ggacgacggg gagaccggcc gtggtgagag tgcgccagtg
     8401 ggcgggggcg gcggtgcgga cggcgagcgg gaaacccgcg tcccgccagg ccgcgcgggc
     8461 cgtgtcgtcg agatcccacc aggcgagctg ggcgccgtga ccggcctggg ccatcgcctt
     8521 gccggccgac atggcgacct cggggttcag ccagagcacc ggggcggccg ggtcgggacc
     8581 ggccggcggc tccgggtcgt cgaggtccgt gccggagacc tggagccggg ccagatcctt
     8641 gggccagccg tcgaggggga ccggcgggaa gacccgcacc tcggccgact tgcccgccac
     8701 ggtgatcccg ggcagcgcct cggcccgccg ccactccgca ccacgcgccc gccgcaccac
     8761 cttgcggatc cgggcgtcct gccagctccg catcgcctcg gcccactctc ccccaccgcc
     8821 cagcgaccgg gcgtcgctca gcatcaccag tacggcgcgc gccgctgtct ccagcgcgtc
     8881 cgtacgcgcc gggggagcgg cccgctcgat ccgcgcgacc agcggcagca cgtactgcgg
     8941 cgcctcgtcg cgcgcggtcc gctcgtcccg gaacgggctg tcctgggcct gcgtgggccc
     9001 agacgcggga gtggggtcgg gggccgggtc gttcgtggtc acgcgcccag tctgccaggc
     9061 ggaagacgcg tttcccggac acgtactcgt ccgtctgtac gaggatgggg gcatggaacg
     9121 tgagttactg ctgaggctgg agggtgtcgg ccgccgctac ggcttccgtg gcgactgggt
     9181 gctgcgggac gtggacctgg agatcgcccc ctccacgctg acccgggtgg agggcgccaa
     9241 cggaaccggc aagtcgatgc tgctccgcgt cctcgccggg ctcgacgcgc ccaccgaggg
     9301 ccgggccacg ggccgcccgc gcacggcgta cgtccccgaa cgcttccccg ccgcgctgcc
     9361 gttcaccgcc gccgagtacc tcacccacct cggcgccgtc cacggtctgg accgcccggc
     9421 cgccgcccgc gccgccgccg agtggctgga gcgcttcggg gccgccgagt acgcccgtac
     9481 gcccatgggg gagctgtcca agggcagcag ccagaaggtc gccgtcgcgc aagccctgct
     9541 cgccgcaccg gagttgctcg tcctcgacga ggcgtggacc ggcctggacg ccgacgcgcg
     9601 cgaggagttg gagcgcgcgg tggtggagcg gacggcggcg ggggcggccg tggtgttcgt
     9661 ggaccacgac ccccggcggt tggcgggggc accggacgcg acgtacgcgg tggtcggggg
     9721 agcgctcgaa ctccggccgg gaaaggggga cttcccggtc tccgtcgtgg tcgaggtgcg
     9781 cgcgccgtcg ggtgcggatg tgccggagga cgtaaggaag tcggcgacgc tgatgcagga
     9841 aatggcgtcc ggcacgcacc ggttcaccgt cccgcagggc gaatccgacg agctgctcag
     9901 ggcgttgctg accgcccggc cgccgtggca cgtggtgagc gtgaccccgg caccggcggc
     9961 gctccccgcc cccgcccccg atcccgatcc cgaacctgcg cctgcgcctg cccccgaact
    10021 ggaaagctcc tgatgaccgc cctcctccgt taccaggcag ctcttctcgt ccgctcccag
    10081 cgctggctgc cgcccgtcat cctgtacgcg gcgttcctcg gcatcggtgt gcagaagggg
    10141 cagccggtgc tcgactcgct cgggtacacg gccgccgcgc tgctgcccgt gtccgcgtgg
    10201 ctgatgcgga tctgtgtcac caacgaaccg cctgcggccc gcagttgtac gggtgcggcg
    10261 gccggtcccg gccgggcgca tctggcctgt gtcctggtcg ccttctcggc ggcggcgctg
    10321 ctcggtacgg cggccacggt cctcgtcacg atcatcagcg cgcccacgag cacggaccac
    10381 cagacccggg tcgagtcgct cccggcgggc ggcgccggcc tgctggccgc gctcgtctgc
    10441 gccctcctcg gcacggccgt cggcgcgctc acgaaccggc cgctgctgcg gtcgcggggc
    10501 cgggccgtcc ccgcgctcct gctgggcgcg ctgctggccc tggtggtggc gggctccccg
    10561 gcacgggcgg cggtcacggc cctggtcgac ggctcgcggc acgcgacgat cccggtgccc
    10621 gtcctgcccc tgctcgcggc aggggtcctc gcggcggcgg ccaccgcggt ggcctgcgcc
    10681 ctgaccaccc gccgcgcggc ctgagcggtt cagccggagc aggcggtccg ctcggcctcc
    10741 cgccactcgc acaccggaca cagggtgatc cccttgtggg actccgggta ctcggtgggc
    10801 ttccggcaca gcacgcactc ggcgaagcgc gggccgtcgt ccgtgacagg ggtggccggg
    10861 gcggccgtct gttcggtgcc gcagtagtcg ctcatgtcgc tcgtgtcgct catatgtcca
    10921 gcgtagagcg acgcgggcag ggcctgccgg ggctcagggc gtcgtcgccg tcgcggcccc
    10981 gaccaggtcc gacaccttca cgaagcggta cccgcgcgcc cggagcaccg gcacgatctt
    11041 ccgtacggcc ttctccgtga ccggggcggc actccgggtg cagtgcatga ccacgaccga
    11101 ccccggccgc accccgtcca gcacctcccg caccacgtcc tcggcgtccg tcgcgaacgc
    11161 gtccccgctc accacgtccc actgcacggc cgtcacaccg gacgcgctga gattccgcag
    11221 cgcgcggctg tcgtagcagc cgccggggaa ccggaagtac ggcatcgggt cccggacgcc
    11281 cgcctcgtgg aacacgcggt acgcccgctc caggtccgcg cgcataccct ccggggccat
    11341 cgtg
//
