LOCUS       NZ_CP045096            10459 bp    DNA     linear   CON 20-NOV-2024
DEFINITION  Streptomyces phaeolivaceus strain GY16 chromosome, complete genome.
ACCESSION   NZ_CP045096
VERSION     NZ_CP045096.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces phaeolivaceus
  ORGANISM  Streptomyces phaeolivaceus
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 10116136)
  AUTHORS   Mo,P.
  TITLE     Streptomyces sp. strain GY16 isolated from leaves of Broussonetia
            papyrifera
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 10116136)
  AUTHORS   Mo,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-OCT-2019) College of Life Science and Technology,
            Central South University of Forestry and Technology, No. 498,
            Shaoshan South Road, Changsha, Hunan 410004, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 15-AUG-2019
            Assembly Method                   :: HGAP v. v. 1.3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 120.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_009184865.1-RS_2024_11_18
            Annotation Date                   :: 11/18/2024 02:51:11
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,113
            CDSs (total)                      :: 9,024
            Genes (coding)                    :: 8,642
            CDSs (with protein)               :: 8,642
            Genes (RNA)                       :: 89
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 382
            CDSs (without protein)            :: 382
            Pseudo Genes (ambiguous residues) :: 0 of 382
            Pseudo Genes (frameshifted)       :: 112 of 382
            Pseudo Genes (incomplete)         :: 305 of 382
            Pseudo Genes (internal stop)      :: 23 of 382
            Pseudo Genes (multiple problems)  :: 53 of 382
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:44:39
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3407485
            Orig. end                         :: 3417944
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP045096.1.
            Bacteria and source DNA available from Yunlin Zhao.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10459
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="melanin"
                     /region_number="15"
                     /rules="melC"
                     /tool="antismash"
     cand_cluster    1..10459
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="melC"
                     /kind="single"
                     /product="melanin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10459
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5459](-)"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5459)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
     gene            50..229
                     /locus_tag="F9278_RS16010"
                     /old_locus_tag="F9278_16020"
     CDS             50..229
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="F9278_RS16010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="F9278_16020"
                     /product="hypothetical protein"
                     /protein_id="WP_152168948.1"
                     /transl_table=11
                     /translation="MKPKQPKVIPAKDIPPAPRGIAGYCWAEHPKTLVHCTEPIGHEAW
                     NPEHYHPYTKTTWR"
     gene            complement(226..594)
                     /locus_tag="F9278_RS48715"
                     /old_locus_tag="F9278_16025"
     CDS             complement(226..594)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024949.5"
                     /locus_tag="F9278_RS48715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F9278_16025"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_152168949.1"
                     /transl_table=11
                     /translation="MPMPAPPPDRSQLDERRQAFGNRLRDARHHVGLTQEQLALRAGMD
                     RSQYSELERGQRDARLSTLLRIERVLGANLSFVVDGPAAATGDECGGPTQAAPYGTDSG
                     AATPGAGDIRGPAPGRPD"
     misc_feature    989..998
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.63"
                     /tool="antismash"
     misc_feature    1070..1085
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.99"
                     /tool="antismash"
     gene            1505..2452
                     /locus_tag="F9278_RS16020"
                     /old_locus_tag="F9278_16030"
     CDS             1505..2452
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018959273.1"
                     /locus_tag="F9278_RS16020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F9278_16030"
                     /product="Fic family protein"
                     /protein_id="WP_226966766.1"
                     /transl_table=11
                     /translation="MRRSAPWTAGSTNCGCPSRWRSETSSWCLIQALADAGGDFRYDAG
                     LLNGLHFMLQGHHLDKRPGRWRDGPVYVTSPDDPLVPAYTAPDQTDVPALMSEFIDWLN
                     EGDLDAPVHVRASMAHLNLVKIHPWKDGNGRMSRALSTLVFSREALMPPEFSSIEEWLG
                     RGQNTYAYYQVLEDVGGPLWSPERDTRPWIRFCLTAHHRQAQQAQRRFDVMSRTWTRLV
                     EAVEPTGLDERVVHALLPAFSDAKVRRTVYQQDADLSDQQAIRDIRELVARGWLAPHGK
                     GRARYYAPGPPMDPVREEVRQSMEPYADPYRRKR"
     gene            2734..2994
                     /locus_tag="F9278_RS47095"
     CDS             2734..2994
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="F9278_RS47095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_226966767.1"
                     /transl_table=11
                     /translation="MATQYFARLLTVLATAGALVLTTPTGAHATAIGSTPVRTFEYSLG
                     GVTMKVPTGCMFTHIIRGGGRKITYQNAGVDCAFVAALSSG"
     gene            3106..3351
                     /locus_tag="F9278_RS16030"
                     /old_locus_tag="F9278_16040"
     CDS             3106..3351
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004928175.1"
                     /locus_tag="F9278_RS16030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F9278_16040"
                     /product="hypothetical protein"
                     /protein_id="WP_152168950.1"
                     /transl_table=11
                     /translation="MIEQQNGENSERVPESRRRRIEIAAFLAGVTVTLAFFAFLPGLPH
                     VIDWGAILLSLLMGGLARWGCRTWLTRAARKQTRSR"
     gene            3685..3972
                     /locus_tag="F9278_RS16035"
                     /old_locus_tag="F9278_16045"
     CDS             3685..3972
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020115467.1"
                     /locus_tag="F9278_RS16035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F9278_16045"
                     /product="chaplin"
                     /protein_id="WP_193241512.1"
                     /transl_table=11
                     /translation="MSRIAKAAVVTLGTSAVVLGGAGLAAADAGAEGKAVGSPGVLSGN
                     VVQVPVNVPVNVCGNTINVVGLLNPAFGNVCVNKSHDSHKGNPGPSGYGH"
     gene            complement(4151..5017)
                     /locus_tag="F9278_RS16040"
                     /old_locus_tag="F9278_16050"
     CDS             complement(4151..5017)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019325459.1"
                     /locus_tag="F9278_RS16040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F9278_16050"
                     /product="tyrosinase family protein"
                     /protein_id="WP_152168952.1"
                     /transl_table=11
                     /translation="MAYTRKDVSTLTRAERKRFVGALLGLKQRGEYDEFVRMHIDHYVS
                     DGDGGLRTAHMAPSFLPWHRRFVLELEKALRRIDDSVTVPYWDWTRDRTTTSAPWTTDL
                     LGGNGRRSDHRVMTGPFAYGTGRWTITEGLTDTEYLTRDFGYPRNPVELPTARDLDAAL
                     AEPVYDKAPWNSVTRGGFRNRLEGWGQGTGNGSWLNHNRVHRWVGGHMVGGASVNDPVF
                     WLHHAFVDLQWTLWQRRHRGARYLPAKPPARGDAQRGRVVARDERMPPWNVTPGALEEI
                     GNVYRYA"
     gene            complement(5001..5459)
                     /locus_tag="F9278_RS16045"
                     /old_locus_tag="F9278_16055"
     CDS             complement(5001..5459)
                     /GO_function="GO:0005507 - copper ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0042438 - melanin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     melanin: melC"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006378445.1"
                     /locus_tag="F9278_RS16045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F9278_16055"
                     /product="tyrosinase family oxidase copper chaperone"
                     /protein_id="WP_404818894.1"
                     /sec_met_domain="melC (E-value: 6.5e-46, bitscore: 155.0,
                     seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLFVSRVTVDPDAGRSRTRRGVLRALGVSAVALAVAPVVAAAWPR
                     RSARSEETDFDETYRGRRIRGARADEGHTAYLGARTPGPGEWDVTVDGRPLHLMRRADG
                     TYLSMIDHYRSYPTALAATRAAVDELGTTQRLRVLDLAEGALGHGLHP"
     gene            complement(5552..6058)
                     /locus_tag="F9278_RS16050"
                     /old_locus_tag="F9278_16060"
     CDS             complement(5552..6058)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013003507.1"
                     /locus_tag="F9278_RS16050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F9278_16060"
                     /product="hypothetical protein"
                     /protein_id="WP_152168953.1"
                     /transl_table=11
                     /translation="MKPTTRGTLAAVVTGVVAAVGASAAPAVAAETVPVPLPLEGVEHS
                     LNVKAPKLAGELPLLMPGAPQGPTYVEGRLLPASAVPQVPLGAALPGLKAETPLPRVVG
                     EGFERVGLDAPAADLRTLTPGLNVDTPLTAPNPDALGLPSLQDPQAAVLTPLLRTAPTA
                     NLGLV"
     misc_feature    complement(6179..6199)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 21.18"
                     /tool="antismash"
     gene            complement(6185..6823)
                     /locus_tag="F9278_RS16055"
                     /old_locus_tag="F9278_16065"
     CDS             complement(6185..6823)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016644657.1"
                     /locus_tag="F9278_RS16055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F9278_16065"
                     /product="vitamin K epoxide reductase family protein"
                     /protein_id="WP_226966768.1"
                     /transl_table=11
                     /translation="MAAPAGRSVDGGVASAGRSVGAVGGGRAFAVLLLITGAAGLLASW
                     VITLDKFKLLEDPNFTPGCSLNPVVSCGNIMKSDQASAFGFPNPMLGLVAYGIVVCVGV
                     SLLAGAGFPRWYWLTFEAGALFGVGFVTWLQFESLYRINSLCLWCCLAWIATIVLFWYL
                     TAFNVRSGFLPAPAGLRSFLDEFPWVPPVVHLGVIGMLILTRWWDFWTS"
     gene            complement(6823..7320)
                     /locus_tag="F9278_RS16060"
                     /old_locus_tag="F9278_16070"
     CDS             complement(6823..7320)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020116484.1"
                     /locus_tag="F9278_RS16060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F9278_16070"
                     /product="DUF5949 family protein"
                     /protein_id="WP_152168954.1"
                     /transl_table=11
                     /translation="MTSTSAETRPFRPADLGTLVVMAWSGEAPDGDMPYLLAYTLGDGQ
                     SGPEGSTAAVTDLLTSLGLSIGEKVVDGAAHPSLPVTLLVEAGQAVVTMPQLNAQCPAP
                     PEWLAAVGERGFAYLLFATRPWPEARPGTPVEPEALAAFAGDTETLISAAHVLLPARSL
                     RS"
     gene            complement(7528..7818)
                     /locus_tag="F9278_RS16065"
                     /old_locus_tag="F9278_16075"
     CDS             complement(7528..7818)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007445910.1"
                     /locus_tag="F9278_RS16065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F9278_16075"
                     /product="hypothetical protein"
                     /protein_id="WP_152168955.1"
                     /transl_table=11
                     /translation="MKSLKAAAVVAGSMAIAGAAAPAFAYDATDVTPTSLNGAVNTLFK
                     GPIEPAPLQQQSNALDTENKDSVLHTVSGATKALNSPGGATQLLGGLPLQG"
     gene            complement(7987..8790)
                     /locus_tag="F9278_RS16070"
                     /old_locus_tag="F9278_16080"
     CDS             complement(7987..8790)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013003503.1"
                     /locus_tag="F9278_RS16070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F9278_16080"
                     /product="hypothetical protein"
                     /protein_id="WP_152168956.1"
                     /transl_table=11
                     /translation="MRALPARRLAVPALCATLLLGVSAPAAMAADVETARDRARSAAAP
                     VPGADALTTQLKGLGDLGGVLGPVTDLLDAVLKADNGQLSADRAEELGEAVRDAIAKAK
                     AADPAAPVEPAAPAAPAVPAVPAAPAVPVAPAVPVAPVAPPAATTPMLPAAPSVPAAPS
                     VPVAPSLPVAPSVPADAQQAVTLPAYDRGSVERVGRVPADLVSDALTALQAAVDALLKA
                     VTSGELAEVLPAVTGVVNSLLKLVAAILLGSGLPVPADLPAVQAP"
     gene            complement(8968..9207)
                     /gene="chpG"
                     /locus_tag="F9278_RS16075"
                     /old_locus_tag="F9278_16085"
     CDS             complement(8968..9207)
                     /codon_start=1
                     /gene="chpG"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007449696.1"
                     /locus_tag="F9278_RS16075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F9278_16085"
                     /product="chaplin ChpG"
                     /protein_id="WP_046708543.1"
                     /transl_table=11
                     /translation="MSRIAKGLALTSVAAAAVAGTAGVATADSEAKGFAAHSPGVLSGN
                     VVQVPVHVPVNVCGNTINVIGLLNPSFGNKCFND"
     misc_feature    9225..9238
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 16.05"
                     /tool="antismash"
     misc_feature    complement(9232..9241)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: medium, score: 16.35"
                     /tool="antismash"
     misc_feature    complement(10415..10429)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.34"
                     /tool="antismash"
ORIGIN
        1 accgatccgt cggcgtctac gcctgcccca cctgccacgg aggagcgaag tgaagccgaa
       61 gcagccgaag gtcatccccg ccaaggacat cccgcccgca ccccgaggca tcgccggtta
      121 ctgctgggcc gagcacccta agacgctcgt ccactgcacc gagcccatcg gccatgaggc
      181 gtggaacccc gagcactacc acccgtacac caagaccacc tggcgctagt ccggtctccc
      241 tggtgccggt cctcggatat cgccggcgcc cggggtggcc gccccgctat cagtgccgta
      301 aggggcggcc tgggtgggcc cgccgcactc gtcccccgtc gcggcggcgg gcccatccac
      361 cacgaagctc aggttcgcgc cgagaacgcg ttcaatccgc agcagcgtcg acagacgggc
      421 gtcccgctgt ccccgctcca gctcggagta ctgagagcgg tccatgccag cccggagtgc
      481 cagttgctcc tgagtgaggc caacgtggtg ccgggcatcg cggagccgat tcccgaaggc
      541 ctgtcgccgc tcgtcgagct ggctgcggtc ggggggcggg gcaggcatgg gcatcttgcc
      601 caacttggcc gcttctgatc atggagtctg taggcgaatt cgccctcaaa tttcaggcga
      661 ggacggcaga atcaccaggc acccgcttgc ccttgtcggc gtggggcggg cggtccgaac
      721 gggcgcacgg tacgggccct cgcgcgaggt actcatccgt ccagatggcg gagccgtgcg
      781 tcttgccgcc ccgggcccct acagtgggct cggggcggcg ctcgtttgct gggcgccgag
      841 tctccgccaa tctccccacg aacattgacc aagcgcctca cctaagtttg gttatcggct
      901 acctgcaaaa acaccaggtg agcacagcgc ttaaccccga acatcttcta agcgcttggc
      961 cgcaggttcg agtcctgccg ggggcgccca ttttttgcag gtcagagcca ctttccagcc
     1021 cttcacgaga tcacctacgg ggggctttcc cattgccctg agcggctctt tgaccctatt
     1081 tgcaccctca catcagactc cccgtcccgc atacgtcccc cgcttcggga gtcgtcgccc
     1141 catggtccgc cctcatctgc gagcaggtcg tgactgatca gagccattct gacggtccat
     1201 cggaaagatg cggagcaggc accgaagtgg cgcccacccc gtcccctgag cgctctggcg
     1261 aggtacccgc ctcctggctt gatctcttgc tcgccaggcc acagcggagg ggcgcggcca
     1321 gtgcattcgg cccactccag gtgcaacgtc cgcaacgaga gcggttgttg aggaacgcaa
     1381 gagggaacca tgaccagagc atggacggtc tgtgggggcc ggttcgggga gcgcgaagaa
     1441 caagcgctgg acgaaggcct ggtgatcgcc ggtgtcgggg acccgctctc acactcttgt
     1501 cccgatgagg cgttcggcac cgtggaccgc tggaagcacc aactgcggct gtccatcacg
     1561 atggagatcg gagacctcgt catggtgcct catccaggcc ctcgccgacg ccggaggcga
     1621 cttccgctac gacgccggcc tgctcaacgg cctgcacttc atgcttcagg gccaccacct
     1681 cgacaaacgc cccggccgct ggcgcgacgg gcccgtctac gtcaccagcc ccgacgaccc
     1741 tctggtcccg gcctataccg ctccggacca gacggacgtc cccgcgttga tgtcggagtt
     1801 catcgactgg ctcaatgagg gcgacctcga cgccccggtc cacgtgcgcg cgtcgatggc
     1861 ccacctcaac ctcgtcaaga tccacccgtg gaaggacggg aacgggcgca tgtcccgagc
     1921 gctctccacc cttgtgttct cccgcgaggc cctgatgccg cccgagttct cgtccatcga
     1981 ggagtggctc ggacggggcc agaacactta cgcctactac caggtcctgg aggacgtagg
     2041 cggtccgctc tggagtccgg agcgggatac acgcccctgg atccggttct gcctcaccgc
     2101 ccaccaccgc caggcgcagc aggcccagcg gcgcttcgac gtgatgtccc gcacctggac
     2161 ccgcctggtc gaagccgtcg aaccaacggg cctggacgag cgcgtcgtcc acgccctgct
     2221 gcccgccttc tcggacgcga aggtccgccg cacggtctac cagcaggacg ccgacctcag
     2281 cgaccagcag gccatccgcg acatccgaga gctcgtcgcc cgcggctggc tcgcccctca
     2341 cggcaagggc cgcgcccgct actacgcacc cggtccgccc atggatccag tccgcgaaga
     2401 ggtccgccag tccatggagc cgtatgcaga cccgtacaga cggaaacggt gacccgcccc
     2461 cctcgcacac ctgcccgtaa tagcgaacct gccggtcagc ggcggttccg ccctcgttgt
     2521 cagtgacgcc ttctaccgtg ccgaggagct gaagcggcgg cgtctggagc ggacgcgcag
     2581 acccggagcc cacggcaagc gttcaatttc gccggtcatc ccgcttatgt cctgatcaca
     2641 cttgatagtg aacctatcaa aatccagcaa ctggcagcgg gagagccaag ttgtcccagg
     2701 tgctcatcaa gagatcacca gaaggggacc attttggcca cgcagtactt cgcgcgcctc
     2761 ctcacggtcc tggccaccgc cggcgcactc gtcctcacca ctccgaccgg agcgcacgcc
     2821 accgcgatcg gctcaactcc cgtgcgcacc ttcgaataca gcctgggtgg cgtaaccatg
     2881 aaggtcccga ccgggtgcat gttcacacac atcatccggg gcggcgggag gaagatcacc
     2941 taccagaacg caggtgtgga ctgcgccttc gtggccgcgc tgagcagcgg ctgaggaaca
     3001 actctcccca gaccctgcct cgttatggga aggcgtgcgc ccacctccac gtcaatggag
     3061 tcaggcgcgt gagccagtgc caccacatca cgaagtgagt cacccatgat cgagcagcag
     3121 aacggcgaga actccgagcg ggttcccgaa tcccggcgcc gtcggatcga gatcgccgcg
     3181 ttcctcgcgg gagtgactgt cacgctcgcc ttcttcgctt tccttccggg acttccccat
     3241 gtcatcgact ggggagccat cctcctgtcc ctgctcatgg gtgggctcgc ccggtggggg
     3301 tgccggacct ggctgacaag ggcagcccgg aagcagacca ggagcaggtg aagtccgaag
     3361 gacagcggtc gtcagccccg gcccgatcgc cccgaactcc cgcgccgacg ccgtcacggc
     3421 gtcggcgcgc gtcaccggcg gagcatctcg aacgggtcgc cgtgcgtgag tcggctcaag
     3481 gactgcccga ggtggttcgg atcgttcgtg gtcgggtcgg aacccgcgtc gtgatcttgg
     3541 tcgccgagat cgaccggaag cacactcccg ttcgggaagg gtgatccccc cggcgaacgc
     3601 cgtgaccccc ggtgcgcggg cgcgttgaag gggcgtgcgg ccacgaagtg ggggtcgtgc
     3661 tcaccgatca agaaggagaa cgtgatgtct cgcatcgcga aggcagccgt cgtcacgctc
     3721 ggcacgtccg ccgttgtgct cggcggcgcc ggcctggccg cggcggacgc gggcgccgag
     3781 ggcaaggccg tcggttcccc gggcgtcctg tcgggcaacg tcgtccaggt ccccgtcaac
     3841 gtgccggtca acgtgtgcgg gaacacgatc aacgtcgtcg gcctgctcaa cccggccttc
     3901 ggcaacgtct gcgtcaacaa gagccacgac agccacaagg gcaaccccgg cccgtccggc
     3961 tacggccact gacgaggccg acaccccgag cggcacgcgg tacccggccc gtggctcaca
     4021 gcagcgacag cggcagcagg agcagcggca cagtttgacg agaagccccc ggcggttcac
     4081 cgtcgggggc ttgtctcgct ctcgggaacg gctctgggga acggctctcg ggaaccgctc
     4141 cagggaaccg ctacgcgtac cggtacacgt tcccgatctc ctccagcgcc cccggagtca
     4201 cattccaggg cggcatccgc tcgtcgcgcg cgacgacccg cccgcgctgc gcgtcacccc
     4261 gtgccggcgg cttggccggc agatagcgcg cgccccggtg ccgccgctgc cagagcgtcc
     4321 actgcaggtc gacgaaggcg tggtgcagcc agaagacggg gtcgttgacg gaggcgccgc
     4381 cgaccatgtg cccgccgacc caccggtgca cccgattgtg gttgagccag gagccgttgc
     4441 cggtcccctg cccccaccct tcgagccggt tgcggaaacc cccgcgggtg acggagttcc
     4501 agggggcctt gtcgtagacc ggctcggcga gcgccgcgtc caggtcacgg gcggtgggca
     4561 gttcgacggg gttgcgcggg taaccgaagt cccgggtgag gtactccgtg tccgtgagcc
     4621 cctccgtgat ggtccaccgt cccgtcccgt acgcgaaggg gccggtcatc acccggtggt
     4681 cggagcgccg tccgttgcca ccgagcaggt ccgtcgtcca gggcgccgac gtcgtcgtac
     4741 ggtcccgggt ccagtcccag tacggcacgg tcaccgagtc gtcgatccgg cgcagcgcct
     4801 tctccagctc cagcacgaac cggcggtgcc agggcaggaa agagggggcc atgtgggccg
     4861 tacgcagacc gccgtcgccg tcggagacgt agtggtcgat gtgcatccgt acgaactcgt
     4921 cgtactcgcc gcgctgtttg agccccagga gcgcgccgac gaaccgcttg cgttccgcgc
     4981 gcgtgagcgt gctgacgtcc ttacgggtgt aggccatggc cgagcgcccc ctccgccagg
     5041 tccagtaccc gcaggcgctg ggtggtgccc agctcgtcga cggcggcgcg ggtcgccgcc
     5101 agggccgtgg gatacgagcg gtagtggtcg atcatgctca gatacgtgcc gtccgcgcgg
     5161 cgcatcagat gcagcgggcg tccgtcgacg gtgacgtccc actcgccggg gccgggcgtc
     5221 cgggcgccca gataggcggt gtggccctcg tcggccctgg ccccacggat acggcggccc
     5281 cggtacgtct cgtcgaagtc ggtctcctcg gaccgcgccg accggcgggg ccacgcggcg
     5341 gcgacgaccg gggccacggc cagggcgacg gccgacacac ccagggcgcg cagcacgcct
     5401 cggcgcgttc tgctccggcc ggcgtcgggg tccaccgtca ctctgctgac gaacaacact
     5461 gtctcctcgt cgtgttcagt agcggtgacc cccggacggc cggacccggg cgcgcacggt
     5521 cccgggcctc gtccgccgtg tcgccgcggg ctcagacgag cccgaggttc gcggtcggcg
     5581 ccgtccgcag cagcggggtg aggacggccg cctgggggtc ctggaggctg ggcaggccca
     5641 gcgcgtcggg gttgggcgcg gtgagcgggg tgtccacgtt cagcccgggg gtcagggtcc
     5701 gcagatcggc ggcgggggcg tcgaggccga cccgctcgaa gccctccccg acgacgcggg
     5761 gcagcggggt ctcggccttc agccccggca gcgcggcacc gagcggcacc tgcggcacgg
     5821 cgctcgcggg cagcagccgc ccctcgacgt acgtcggccc ctggggggcg ccgggcatca
     5881 gcagcggcaa ctcgcccgcc agcttgggcg ccttcacgtt cagggagtgc tccacacctt
     5941 cgagcggcag ggggacgggg accgtctcgg ccgcgacggc gggggcggcg gaggcgccca
     6001 ccgcggccac cacaccggtg acgacggcgg caagggttcc tcgtgtggtc ggcttcatct
     6061 cggtacggtc cctttcaagg aatgagcgga tccgggctcg gcgtccgtac cgggtgaacg
     6121 atccggggat ctccccgagc gcaagattcg cccgactgcc gcaatagtcc gagagacgta
     6181 ttggtcagct tgtccagaag tcccaccagc gggtcaggat gagcattccg atcactccga
     6241 ggtgcaccac cggaggcacc caggggaatt cgtcgagaaa gctcctcagc ccggccggcg
     6301 cgggcaggaa accgctgcgg acgttgaacg cggtcaggta ccagaagagg acgatcgtgg
     6361 cgatccaggc cagacagcac cacagacaga gtgagttgat ccggtacagc gactcgaact
     6421 gcagccaggt cacgaagccg accccgaaca gcgcgcccgc ctcgaaggtc agccagtacc
     6481 agcgcgggaa gcccgccccg gccagcaggc tcacgccgac gcagacgacg atgccgtagg
     6541 ccaccagacc tagcatcggg ttggggaacc cgaaggcgga ggcctggtcg ctcttcatga
     6601 tgttgccgca ggagaccacc gggttgaggc tgcacccggg ggtgaagttc gggtcctcca
     6661 gcagcttgaa cttgtcgagc gtgatgaccc aggaggcgag cagcccggcc gcaccggtga
     6721 tcagcagcag taccgcgaag gcccggccgc cgccgaccgc gcccaccgac cgccccgccg
     6781 aggccacccc tccgtccacc gaccgccctg ccggggcggc catcagctgc gcaggctgcg
     6841 ggccggcagg aggacgtgcg ccgcgctgat cagcgtctcg gtgtcgcccg cgaaggcggc
     6901 gagggcctcg ggctcgacgg gcgtgccggg ccgggcctcg ggccaggggc gggtcgcgaa
     6961 gagcaggtag gcgaagccgc gttcgccgac ggcggcgagc cactccggcg gggccgggca
     7021 ctgggcgttg agctgcggca tggtgacgac ggcctggccc gcctcgacga gcagggtgac
     7081 cggcaggctg ggatgggcgg cgccgtcgac gaccttctcg ccgatggaca gaccgaggct
     7141 cgtcagcaga tccgtcacgg cggccgtgga gccctcgggg ccgctctggc cgtcgccgag
     7201 ggtgtaggcg agcagataag gcatgtcccc gtcgggggct tcaccgctcc acgccatgac
     7261 gacgagggtg ccgaggtcgg cggggcggaa agggcgagtt tcagcggaag ttgaagtcac
     7321 cgcggaaccc tatccacgcc cgccaaacaa cctggccgcc ttttcacccg accgggcgac
     7381 acacgacggc cgaccacacg aacgagggac acgcctcgaa caacggtgaa ttcacgctcc
     7441 cgagggacgg aggaaagggc gggagaaccc acggggccgg tgccgcgtca tcgcggaacc
     7501 ggccccgtgg gactgggaaa gggatcgtca gccctggagg ggcagaccgc cgaggagctg
     7561 ggtggcgccg ccgggcgagt tgagcgcctt ggtcgcgccg ctcaccgtgt ggagcacgga
     7621 gtccttgttc tccgtgtcga gcgcgttcga ctgctgctgc agcggcgcgg gctcgatggg
     7681 ccccttgaag agcgtgttca ccgcgccgtt gaggctggtg ggcgtgacgt ccgtggcgtc
     7741 gtaggcaaaa gccggcgcgg cggcaccggc gatggccatg gaccctgcga cgacagcggc
     7801 ggccttcagc gacttcatcg tgttcctctc ctcggatact ggaagctctg cgccgtgtcc
     7861 aacgagccct cgcgccgacg gaaaccccgt accggacatg tcatatctga cgccgaacga
     7921 caggtcatac gaaacagccg ccggaccgcc ccggactgcg ggcgacccga cggctcgctt
     7981 cggttcctac ggcgcctgca cggccggcag gtcggccggg acgggcaggc cgctgcccag
     8041 gaggatggcc gcgaccagct tgagcaggct gttcaccaca ccggtgacag cgggcagcac
     8101 ctcggcgagt tcgccggagg tgaccgcctt gagcagcgcg tcgaccgccg cctggagcgc
     8161 ggtcagcgcg tcggacacga ggtccgccgg gactctgccg acccgttcga cggacccgcg
     8221 gtcgtacgcc ggcaacgtca cggcctgctg cgcatcggcc gggacggacg gggccaccgg
     8281 gagggatggc gccaccggga cggagggagc cgccgggacc gaaggggccg ccgggagcat
     8341 gggcgtggtc gcggcgggcg gggcgacggg cgcgaccggt acggcgggcg cgaccggtac
     8401 ggcgggcgcg gccggaaccg caggcaccgc cggcgccgcg ggcgcggccg gttcgaccgg
     8461 tgcggccgga tccgccgcct tcgccttggc gatggcgtcc cgtacggcct cgccgagttc
     8521 ctcggcgcgg tcggcggaga gctggccgtt gtccgccttg agcacggcgt cgagcagatc
     8581 ggtcaccggc ccgagtacgc cgccgaggtc gccgagaccc ttgagctggg tcgtcagcgc
     8641 gtccgcgccg gggacgggcg ccgccgccga ccgggcgcgg tcacgcgccg tctcgacgtc
     8701 ggcggccatg gcggccgggg cggagacgcc gagcaggagg gtggcgcaga gtgcggggac
     8761 cgcgagacgc cgtgcgggca gagcacgcat ggatgttcct ttccatcggt gcgagggatc
     8821 gttccttcac cgtgaaatcg gtgatcgcgg cctgcaaccg agggacccca ttcggggcaa
     8881 cacgaaccgg ccgccctccc cgtggggagg acggccggtt cgttgttaac gcgcgaacgt
     8941 cagtgcgggg acgtcagtcc tcgaacgtca gtcgttgaag cacttgttgc cgaacgaggg
     9001 gttcagcaga ccgatgacgt tgatggtgtt cccgcacacg ttgaccggca cgtggaccgg
     9061 aacctgcacg acgttgcccg acagcacgcc cggggagtga gcggcgaagc ccttcgcctc
     9121 gctgtcggcg gtggcgacgc cggcggtgcc cgccacggcc gcggcagcaa cggaggtcag
     9181 ggccaggccc ttcgcgatac gcgacatgga gaggtgctcc ttggagttga tgcaaaaaac
     9241 actcgggcgg ggatgcccgg cgctggataa acgcgcggca tgcaccgggg gttgtgcctc
     9301 caaaggagtg atctccgaaa acggctgctt caccattccg acacagttgg cgcgttccgc
     9361 agataaatac acatagcggg ctagagttgc gcacctcccc aggccgccgc ggccattatc
     9421 agatccgcag gatttcggcc tttcgacggt ccgcgacatt cccccgtaca agcacccgaa
     9481 cgagctcccg aaagggcacc gccggtcatg cgaattcacc cgggtcctct gctgcgtcgc
     9541 gccatggtgg gctgctgcgc cctcgccgca ctctgggggc ccggcgcccc cgcgacggcc
     9601 gcgccccccg cgccctcgcc cgaggccgag cggctggcct tcgcccagcg tcatcgggcc
     9661 ctgcagcacg gcggcatcgt ccgcgcggcc aactcctcca tcacctgccg tacgacggcg
     9721 acctcctgcg ccgacgcgcg cgcggggcgc accctcctgg acccggcgcg caccggcgtc
     9781 aacgacgact tcgacatgtt ctacatcgac gtcgaccagg acccgaacac ctacaactcc
     9841 agccggggcg aggtccggct gccgccgggc tcgcgggtgt cgtacgcgcg gctgtactgg
     9901 ggcgggaacc tgcgggtggg cgagcagaag ccgccgaagg acaacgggcg ggtgctgatc
     9961 gcggagcccg gcggcgagta caaggaggtg ctcgcggact cggtggtggg acaccgggtg
    10021 gcgcgcggcg cggacgcgtt ccaggcctcg gcggacgtca cggagctggt gcggtcgagc
    10081 ggttccgggc tctacacggt ggcccaggtc aatgtggcca tgggccgttc ggcggccggg
    10141 gcgtggggcg gctggacgct gatggtggcg tacgagaacc cggcggagcc gctgcggcat
    10201 ctggcgatgt gggacggctt cgacgcgctc gcggcgggcg gggagcagac gatccggctg
    10261 cggggcacgg ccttccccgc gggtgcccgg ggcaccgtgg gcctggtcgc ctacaacggg
    10321 gaccgagggc gcaccggtga ttcgctcacc gtttcgacgg gtgaaggtga ggccagtgcc
    10381 ctggaggacg cggccaaccc ccatgacgac ctcctgaact cgacgatcag ccagccagga
    10441 gcggtcgtcg cggggcgta
//
