GCF_008935075.1 - 5 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP044545.1 (Pradoshia sp. D12)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	terpene-precursor	495,958	518,339
Region 2	betalactone	1,768,069	1,808,096	Low	fengycin	NRPS:Type I
Region 3	terpene	2,015,624	2,037,498
Region 4	terpene-precursor	2,758,355	2,779,242
Region 5	lanthipeptide-class-ii	3,708,765	3,731,878

NZ_CP044545.1 - Region 1 - terpene-precursor

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Location: 495,958 - 518,339 nt. (total: 22,382 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

F7984_RS02530: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

F7984_RS02540: alcohol dehydrogenase

smcogs: SMCOG1040: alcohol dehydrogenase

F7984_RS02545: alcohol dehydrogenase

smcogs: SMCOG1040: alcohol dehydrogenase

Transferases: kinase

F7984_RS02490: glycerol kinase

smcogs: SMCOG1210: glycerol kinase

F7984_RS02535: PfkB domain protein

smcogs: SMCOG1276: PfkB domain protein

Ligases: synthetase

F7984_RS02515: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Translocases: permease

F7984_RS02550: phenylalanine-specific permease

smcogs: SMCOG1038: phenylalanine-specific permease

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000016.4	0.43	other (other)	amphotericin B	Streptomyces nodosus
BGC0002402.2	0.40	terpene	Yossoside I, Yossoside II, Yossoside III, Yossoside IV, Yossoside V	Spinacia oleracea
BGC0001610.5	0.39	other (other)	gougerotin	Streptomyces ahygroscopicus subsp. wuzhouensis
BGC0001910.4	0.38	terpene	cyslabdan A, cyslabdan B, cyslabdan C	Streptomyces cyslabdanicus
BGC0001456.3	0.37	terpene	isorenieratene	Streptomyces argillaceus
BGC0000639.3	0.37	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000641.3	0.37	terpene	carotenoid	Enterobacteriaceae bacterium DC416
BGC0000664.5	0.37	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000649.3	0.37	terpene	carotenoid	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001687.3	0.37	other (other)	N-tetradecanoyl tyrosine	uncultured bacterium CSL12

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000016.4	0.43	other (other)	amphotericin B	Streptomyces nodosus
BGC0002402.2	0.40	terpene	Yossoside I, Yossoside II, Yossoside III, Yossoside IV, Yossoside V	Spinacia oleracea
BGC0001610.5	0.39	other (other)	gougerotin	Streptomyces ahygroscopicus subsp. wuzhouensis
BGC0001910.4	0.38	terpene	cyslabdan A, cyslabdan B, cyslabdan C	Streptomyces cyslabdanicus
BGC0001456.3	0.37	terpene	isorenieratene	Streptomyces argillaceus
BGC0000639.3	0.37	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000641.3	0.37	terpene	carotenoid	Enterobacteriaceae bacterium DC416
BGC0000664.5	0.37	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000649.3	0.37	terpene	carotenoid	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001687.3	0.37	other (other)	N-tetradecanoyl tyrosine	uncultured bacterium CSL12

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor	FPP	C15	acyclic	PP
diterpene precursor	GGPP	C20	acyclic	PP
sesterterpene precursor	GFPP	C25	acyclic	PP
triterpene precursor	HPP	C30	acyclic	PP

Genes with terpene domains:

F7984_RS02515: PT_FPPS_like

Domain 1 (535 - 755): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

Transcription Factor Binding Sites

Binding sites found:

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 24.68 out of 28.14

Confidence: medium

Additional weak hits (1):

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 23.60 out of 30.97

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
PerR	Peroxide regulator

NZ_CP044545.1 - Region 2 - betalactone

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Location: 1,768,069 - 1,808,096 nt. (total: 40,028 nt) Show pHMM detection rules used

betalactone: (HMGL-like and AMP-binding)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

F7984_RS08675: acyl-CoA dehydrogenase type 2

smcogs: SMCOG1191: acyl-CoA dehydrogenase type 2

F7984_RS08690: flavin reductase domain protein FMN-binding

smcogs: SMCOG1160: flavin reductase domain protein FMN-binding

F7984_RS08710: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

F7984_RS08730: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

Transferases: carboxylase transferase transketolase

F7984_RS08740: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

F7984_RS08760: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

F7984_RS08800: transketolase

smcogs: SMCOG1204: transketolase

Hydrolases: dehalogenase

F7984_RS08670: haloalkane dehalogenase

smcogs: SMCOG1262: haloalkane dehalogenase

Lyases: hydratase

F7984_RS08755: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

Ligases: ligase synthase

F7984_RS08685: 2-isopropylmalate synthase

smcogs: SMCOG1271: 2-isopropylmalate synthase

F7984_RS08720: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

F7984_RS08735: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

F7984_RS08750: 2-isopropylmalate synthase

smcogs: SMCOG1271: 2-isopropylmalate synthase

F7984_RS08765: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001160.5	0.57	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0002276.2	0.57	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001164.3	0.57	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001251.4	0.56	NRPS	epichloenin A	Epichloe festucae
BGC0001250.4	0.56	NRPS	epichloenin A	Epichloe festucae
BGC0002277.2	0.56	NRPS	atromentin	Suillus grevillei
BGC0002274.2	0.56	NRPS	aspulvinone H, aspulvinone B1	Aspergillus terreus NIH2624
BGC0000357.5	0.55	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0002284.3	0.53	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0001103.5	0.50	NRPS, PKS	mycosubtilin	Bacillus subtilis subsp. spizizenii ATCC 6633

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001160.5	0.57	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0002276.2	0.57	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001164.3	0.57	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001251.4	0.56	NRPS	epichloenin A	Epichloe festucae
BGC0001250.4	0.56	NRPS	epichloenin A	Epichloe festucae
BGC0002277.2	0.56	NRPS	atromentin	Suillus grevillei
BGC0002274.2	0.56	NRPS	aspulvinone H, aspulvinone B1	Aspergillus terreus NIH2624
BGC0000357.5	0.55	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0002284.3	0.53	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0001103.5	0.50	NRPS, PKS	mycosubtilin	Bacillus subtilis subsp. spizizenii ATCC 6633

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.78 out of 20.97

Confidence: strong

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.06 out of 28.19

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 23.65 out of 28.19

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 22.42 out of 24.78

Confidence: strong

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 22.78 out of 24.78

Confidence: strong

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 22.28 out of 24.78

Confidence: medium

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 25.49 out of 29.65

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.60 out of 26.06

Confidence: medium

Additional weak hits (3):

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.98 out of 29.65

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 24.73 out of 35.63

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.47 out of 26.85

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CcpA	Catabolite control protein A
LexA variant 1	Repressor of DNA damage response
LexA variant 2	Repressor of DNA damage response
MogR	Repressor of flagellar motility genes
ZuR variant 1	Zinc-responsive repressor

NZ_CP044545.1 - Region 3 - terpene

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Location: 2,015,624 - 2,037,498 nt. (total: 21,875 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase reductase

F7984_RS09720: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

F7984_RS09780: alkyl hydroperoxide reductase subunit

smcogs: SMCOG1176: alkyl hydroperoxide reductase subunit

F7984_RS09785: alkyl hydroperoxide reductase/ Thiol specific

smcogs: SMCOG1196: alkyl hydroperoxide reductase/ Thiol specific

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000663.5	0.34	terpene	hopene	Streptomyces coelicolor A3(2)
BGC0002253.3	0.34	PKS	waikikiamide A, waikikiamide B, waikikiamide C, (+)-semivioxanthin, semivioxanthin	Aspergillus sp. FM242
BGC0001591.4	0.32	other (other)	fatty acid enol ester, N-tetradecanoyl tyrosine	uncultured bacterium CSLC2
BGC0001826.3	0.32	NRPS	xeneprotides A-C	Xenorhabdus sp. KJ12.1
BGC0001866.4	0.30	PKS	viriditoxin	Byssochlamys spectabilis
BGC0000304.4	0.29	NRPS	apicidin	Fusarium incarnatum
BGC0000207.5	0.28	PKS	chartreusin	Streptomyces chartreusis
BGC0001114.5	0.27	NRPS, PKS	thailanstatin A	Burkholderia thailandensis
BGC0002712.2	0.27	PKS	WS-5995 D, WS-5995 B, WS-5995 C, SEK 43	Streptomyces yanglinensis
BGC0000298.5	0.27	NRPS	aeruginosin 98-A, aeruginosin 98-B, aeruginosin 98-C	Microcystis aeruginosa NIES-98

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000663.5	0.34	terpene	hopene	Streptomyces coelicolor A3(2)
BGC0002253.3	0.34	PKS	waikikiamide A, waikikiamide B, waikikiamide C, (+)-semivioxanthin, semivioxanthin	Aspergillus sp. FM242
BGC0001591.4	0.32	other (other)	fatty acid enol ester, N-tetradecanoyl tyrosine	uncultured bacterium CSLC2
BGC0001826.3	0.32	NRPS	xeneprotides A-C	Xenorhabdus sp. KJ12.1
BGC0001866.4	0.30	PKS	viriditoxin	Byssochlamys spectabilis
BGC0000304.4	0.29	NRPS	apicidin	Fusarium incarnatum
BGC0000207.5	0.28	PKS	chartreusin	Streptomyces chartreusis
BGC0001114.5	0.27	NRPS, PKS	thailanstatin A	Burkholderia thailandensis
BGC0002712.2	0.27	PKS	WS-5995 D, WS-5995 B, WS-5995 C, SEK 43	Streptomyces yanglinensis
BGC0000298.5	0.27	NRPS	aeruginosin 98-A, aeruginosin 98-B, aeruginosin 98-C	Microcystis aeruginosa NIES-98

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
triterpene	hopanoid		C30	hopanoid skeleton	unknown
triterpene	polypodane		C30	polypodane skeleton	unknown

Genes with terpene domains:

F7984_RS09750: T2TS

Domain 1 (3 - 618): Type 2 terpene synthase

Subtype: Squalene substrate

Reactions:: squalene → hopanoid; squalene → polypodane

Transcription Factor Binding Sites

Binding sites found:

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 26.48 out of 28.14

Confidence: strong

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.59 out of 23.05

Confidence: medium

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 24.88 out of 28.14

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.17 out of 29.38

Confidence: medium

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.58 out of 21.84

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.14 out of 28.19

Confidence: medium

Additional weak hits (7):

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 22.66 out of 26.12

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 23.71 out of 30.97

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 23.71 out of 30.97

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 24.04 out of 28.14

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 23.46 out of 28.14

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.89 out of 29.38

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 23.79 out of 35.63

Confidence: weak

Terpene

TFBS Finder

Glossary

No acronyms to display

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production
FuR variant 1	Ferric Uptake Regulator
MexT	Global virulence regulator
PerR	Peroxide regulator
ZuR variant 1	Zinc-responsive repressor

NZ_CP044545.1 - Region 4 - terpene-precursor

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Location: 2,758,355 - 2,779,242 nt. (total: 20,888 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: carboxylase

F7984_RS13270: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Ligases: synthase synthetase

F7984_RS13230: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs: SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

F7984_RS13240: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002283.2	0.49	terpene	sodorifen	Serratia plymuthica
BGC0001361.3	0.49	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002397.2	0.48	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.39	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0002219.2	0.39	terpene	(-)-(R)-nephthenol	Stereum hirsutum FP-91666 SS1
BGC0000665.5	0.38	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0002284.3	0.38	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000639.3	0.38	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000642.3	0.38	terpene	carotenoid	Enterobacteriaceae bacterium DC413

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002283.2	0.49	terpene	sodorifen	Serratia plymuthica
BGC0001361.3	0.49	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002397.2	0.48	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.39	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0002219.2	0.39	terpene	(-)-(R)-nephthenol	Stereum hirsutum FP-91666 SS1
BGC0000665.5	0.38	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0002284.3	0.38	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000639.3	0.38	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000642.3	0.38	terpene	carotenoid	Enterobacteriaceae bacterium DC413

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

F7984_RS13240: PT_FPPS_like

Domain 1 (32 - 295): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: DMAPP, IPP → FPP

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (2):

RicR

Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 21.62 out of 32.93

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 23.64 out of 31.73

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description

NZ_CP044545.1 - Region 5 - lanthipeptide-class-ii

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Location: 3,708,765 - 3,731,878 nt. (total: 23,114 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

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Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

F7984_RS17885: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Lyases: cyclase

F7984_RS17850: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000504.5	0.56	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000500.5	0.51	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000554.4	0.51	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000525.5	0.50	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000623.3	0.49	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0001555.4	0.47	ribosomal	colicin V	Escherichia coli chi7122
BGC0002698.2	0.47	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0002674.2	0.47	ribosomal	enterocin F4-9	Enterococcus faecalis
BGC0000516.4	0.46	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0001210.5	0.46	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000504.5	0.56	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000500.5	0.51	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000554.4	0.51	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000525.5	0.50	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000623.3	0.49	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0001555.4	0.47	ribosomal	colicin V	Escherichia coli chi7122
BGC0002698.2	0.47	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0002674.2	0.47	ribosomal	enterocin F4-9	Enterococcus faecalis
BGC0000516.4	0.46	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0001210.5	0.46	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for F7984_RS17850

F7984_RS17855

Leader:

MSSEEIIMRWKNPELRDGTSISHPSGLGFQELDLKEISSVCGG

Core:

NGEIQPQGTPAATVISALASFVGSYLVTAVFCK

Core with dehydrations:

NGEIQPQGDhbPAADhbVIDhaALADhaFVGDhaYLVDhbAVFCysK

antiSMASH-DB 4.0 matches for F7984_RS17855

100.0%

NZ_CP044545.1:

Lanthipeptides: F7984_RS17855_lanthipeptide

NGEIQPQGTPAATVISALASFVGSYLVTAVFCK

43.2%

NZ_LT800494.1:

Lanthipeptides: B7E07_RS02625_lanthipeptide

NGEIQPQGTPAATVISALA----SFVGSYLVTAVFCK

+G +PQ TP + SAL S S +TAVFCK

SGVAEPQATPTIALTSALVGAPVSAFASLTITAVFCK

42.4%

NZ_JACSPZ010000014.1:

Lanthipeptides: H9635_RS18395_lanthipeptide

EIQPQGTPAATVISALASFVGSYLVTAVF

EIQPQ TP L SF+ SY+++A F

EIQPQSTP-------LCSFLASYIISAQF

with 67 more sequence matches

Only the first 10 are displayed here.

41.2%

NZ_KN125582.1:

Lanthipeptides: DJ91_RS27545_lanthipeptide

IQPQGTPAATVISALASFVGSYLVTAVF

+ P+ TPA T+ LASFV SY+ +A F

VTPRTTPATTL---LASFVASYIASAEF

39.4%

NZ_LT904904.1:

Lanthipeptides: C1726_RS21985_lanthipeptide

GEIQPQGTPAATVISALASFVGSYLVTAVFCK

G+IQP TP+ S F G LV+ +FC

GDIQPNTTPS----SIPCGFGGGILVSMLFCN

34.3%

NZ_FNYB01000021.1and 1 other:

NZ_NVMQ01000017.1 Lanthipeptides: CON32_RS17790_lanthipeptide

Lanthipeptides: BMZ34_RS24355_lanthipeptide

IQPQGTPAATVISALASFVGSYLVTAVF

+ P+ TP+ LASFV SY+ +A F

VDPRTTPSPL----LASFVASYIASAEF

34.3%

NZ_KB976303.1:

Lanthipeptides: IGY_RS26050_lanthipeptide

IQPQGTPAATVISALASFVGSYLVTAVF

+ P+ TP+ LASFV SY+ +A F

VDPRTTPSPL----LASFVASYIASAQF

33.3%

NZ_CP012102.1and 1 other:

NZ_CP012102.1 Lanthipeptides: AC241_RS31310_lanthipeptide

Lanthipeptides: AC241_RS31310_lanthipeptide

GEIQPQGTPAATVISALASFVGSYLVTAVFC

G++QP+ TPA + A+A++ G++ +T +C

GDVQPETTPACGI--AIAAW-GAHELTYFYC

33.3%

NZ_CP025701.1:

Lanthipeptides: C0569_RS26125_lanthipeptide

GEIQPQGTPAATV-------ISALASFVG

G+++P+ TPA I ALAS G

GDVKPETTPACLAGFTVGLGIGALASAAG

33.3%

NZ_JACSNF010000005.1and 1 other:

NZ_LMPR01000013.1 Lanthipeptides: ASF99_RS16385_lanthipeptide

Lanthipeptides: KNQ12_RS14670_lanthipeptide

AATVISALASFVGSYLVTA

++ V SAL SFVGSYL +A

SSLVCSALLSFVGSYLASA

33.3%

NZ_NVAW01000030.1and 1 other:

NZ_NVEP01000021.1 Lanthipeptides: COL17_RS24445_lanthipeptide

Lanthipeptides: COK11_RS25885_lanthipeptide

GEIQPQGTPAATV-------ISALASFVG

G+++P+ TPA I ALAS G

GDVKPETTPACLAGFTIGLGIGALASAAG

31.4%

NZ_FNYB01000021.1:

Lanthipeptides: BMZ34_RS24360_lanthipeptide

IQPQGTPAATVISALASFVGSYLVTAVF

+ P+ TP+ LASFV SY+ +A +

VDPRTTPSPL----LASFVASYIASAQY

30.3%

NC_021362.1and 29 others:

NC_021362.1 Lanthipeptides: BALI_RS00915_lanthipeptideNZ_AP025342.1 Lanthipeptides: L6430_RS07475_lanthipeptideNZ_AP025342.1 Lanthipeptides: L6430_RS07475_lanthipeptideNZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20090_lanthipeptideNZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20090_lanthipeptideNZ_CP010524.1 Lanthipeptides: SC10_RS00915_lanthipeptideNZ_CP010524.1 Lanthipeptides: SC10_RS00915_lanthipeptideNZ_CP020352.1 Lanthipeptides: BLMD_RS01010_lanthipeptideNZ_CP020352.1 Lanthipeptides: BLMD_RS01010_lanthipeptideNZ_CP023168.1 Lanthipeptides: CK945_RS01010_lanthipeptideNZ_CP023168.1 Lanthipeptides: CK945_RS01010_lanthipeptideNZ_CP118744.1 Lanthipeptides: PWG69_RS01010_lanthipeptideNZ_CP118744.1 Lanthipeptides: PWG69_RS01010_lanthipeptideNZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20270_lanthipeptideNZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20270_lanthipeptideNZ_KN125579.1 Lanthipeptides: DJ88_RS03665_lanthipeptideNZ_KN125579.1 Lanthipeptides: DJ88_RS03665_lanthipeptideNZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19045_lanthipeptideNZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19045_lanthipeptideNZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16135_lanthipeptideNZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16135_lanthipeptideNZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11925_lanthipeptideNZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11925_lanthipeptideNZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01510_lanthipeptideNZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01510_lanthipeptideNZ_NKBC01000001.1 Lanthipeptides: CE036_RS00070_lanthipeptideNZ_NKBC01000001.1 Lanthipeptides: CE036_RS00070_lanthipeptideNZ_QXII01000007.1 Lanthipeptides: D1791_RS21810_lanthipeptideNZ_QXII01000007.1 Lanthipeptides: D1791_RS21810_lanthipeptide

Lanthipeptides: BALI_RS00915_lanthipeptide

GEIQPQGTPAATVISALASFVGSYLVTAVFC

++ P TP+ S LVTAV+C

ADVTPHTTPS--------SLPCGTLVTAVWC

F7984_RS17865

Leader:

MNEREVVADLIRIVGS

Core:

VNSRVSKSESDLRKIEQTLQILIKELSNMKELQYQLCEQTYQLHEH

Core with dehydrations:

VNDhaRVDhaKDhaEDhaDLRKIEQDhbLQILIKELDhaNMKELQYQLCysEQDhbYQLHEH

antiSMASH-DB 4.0 matches for F7984_RS17865

100.0%

NZ_CP044545.1:

Lanthipeptides: F7984_RS17865_lanthipeptide

VNSRVSKSESDLRKIEQTLQILIKELSNMKELQYQLCEQTYQLHEH

19.6%

NZ_CP076356.1:

Lanthipeptides: allorf_0466225_0466353_lanthipeptide

QTLQILIKELSNMKELQYQLCEQT

+T+Q+L+ + SN LCE T

RTIQLLVSKSSNNGRSTGVLCECT

allorf_3727736_3727957

Leader:

MLVAGLQDVGHEDVAKGRGAFSLRSLNKALQLYSVIQLRRLEAQDISMTSAGG

Core:

RTPPSDVLSYAPREPTGCRS

Core with dehydrations:

RDhbPPDhaDVLDhaYAPREPDhbGCysRDha

antiSMASH-DB 4.0 matches for allorf_3727736_3727957

100.0%

NZ_CP044545.1:

Lanthipeptides: allorf_3727736_3727957_lanthipeptide

RTPPSDVLSYAPREPTGCRS

35.0%

NZ_CP081497.1:

Lanthipeptides: allorf_2111783_2111890_lanthipeptide

PSDVLSYAPREPTGC

PS+VLS GC

PSNVLSTLLHADIGC

25.0%

NZ_CP067395.1:

Lanthipeptides: allorf_4557282_4557398_lanthipeptide

LSYAPREPTGCR

LS PR P CR

LSKTPRSPRECR

allorf_3730661_3730834

Leader:

MKGRGKQVWSTYALAMRYLYPGKGRSKVGERQRKAGM

Core:

VHLCPGYEAPIPGYRSVKGR

Core with dehydrations:

VHLCysPGYEAPIPGYRDhaVKGR

antiSMASH-DB 4.0 matches for allorf_3730661_3730834

100.0%

NZ_CP044545.1:

Lanthipeptides: allorf_3730661_3730834_lanthipeptide

VHLCPGYEAPIPGYRSVKGR

25.0%

NZ_AP018268.1:

Lanthipeptides: CDC39_RS06790_lanthipeptide

LCPGYEAPIPGYRSVKGR

+C G+ PI R R

ICTGWTTPIICLRYTMFR

25.0%

NZ_CP007153.1:

Lanthipeptides: allorf_02389419_02389625_lanthipeptide

EAPIPGYRSV

EAP PG+ S

EAPCPGWPST

with 2 more sequence matches

18.4%

NZ_CP091282.1:

Lanthipeptides: L2Z53_RS12190_lanthipeptide

GYEAPIPGYRSVKGR

GYE I ++VKG+

GYELSIHVAKTVKGK

14.0%

NZ_CP095742.1:

Lanthipeptides: allorf_0677509_0677667_lanthipeptide

CPGYEAPIPGYRSV

CP + P+P SV

CPQHSGPLPPATSV

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 17.14 out of 18.16

Confidence: strong

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.73 out of 29.25

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.41 out of 26.06

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.55 out of 19.26

Confidence: medium

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.54 out of 18.46

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 23.18 out of 28.19

Confidence: medium

Additional weak hits (3):

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.11 out of 25.75

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 23.99 out of 33.14

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 23.85 out of 36.53

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

F7984_RS17855 - Class II

Cleavage pHMM score: -3.00

RODEO score: 0

Monoisotopic mass: 3230.7 Da

Molecular weight: 3232.7 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 3250.7 Da N = 1; 3268.7 Da N = 2; 3286.7 Da N = 3; 3304.8 Da N = 4; 3322.8 Da N = 5

F7984_RS17865 - Class II

Cleavage pHMM score: -6.90

RODEO score: 0

Monoisotopic mass: 5402.8 Da

Molecular weight: 5406.1 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 5424.1 Da N = 1; 5442.1 Da N = 2; 5460.1 Da N = 3; 5478.2 Da N = 4; 5496.2 Da N = 5; 5514.2 Da N = 6

allorf_3727736_3727957 - Class II

Cleavage pHMM score: -1.70

RODEO score: 0

Monoisotopic mass: 2098.1 Da

Molecular weight: 2099.3 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2117.3 Da N = 1; 2135.3 Da N = 2; 2153.4 Da N = 3; 2171.4 Da N = 4

allorf_3730661_3730834 - Class II

Cleavage pHMM score: -4.20

RODEO score: 0

Monoisotopic mass: 2180.1 Da

Molecular weight: 2181.5 Da

Number of bridges: 1

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
CRP	Cyclic AMP receptor protein
MogR	Repressor of flagellar motility genes
RpoN	Regulator of nitrogen assimilation and virulence
SypG	Regulator of biofilm formation and host colonization
ZuR variant 1	Zinc-responsive repressor