LOCUS       NZ_CP044545            23114 bp    DNA     circular CON 16-NOV-2023
DEFINITION  Pradoshia sp. D12 chromosome, complete genome.
ACCESSION   NZ_CP044545
VERSION     NZ_CP044545.1
KEYWORDS    RefSeq.
SOURCE      Pradoshia sp. D12
  ORGANISM  Pradoshia sp. D12
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Pradoshia.
REFERENCE   1  (bases 1 to 3934149)
  AUTHORS   Meng,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-OCT-2019) National Institute for Communicable Disease
            Control and Prevetion, China CDC, CHANGBAI Road No. 155, Beijing
            102206, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. Jun-2019
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 237.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 11/16/2023 02:43:39
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 3,855
            CDSs (total)                      :: 3,730
            Genes (coding)                    :: 3,692
            CDSs (with protein)               :: 3,692
            Genes (RNA)                       :: 125
            rRNAs                             :: 10, 9, 9 (5S, 16S, 23S)
            complete rRNAs                    :: 10, 9, 9 (5S, 16S, 23S)
            tRNAs                             :: 92
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 38
            CDSs (without protein)            :: 38
            Pseudo Genes (ambiguous residues) :: 0 of 38
            Pseudo Genes (frameshifted)       :: 16 of 38
            Pseudo Genes (incomplete)         :: 21 of 38
            Pseudo Genes (internal stop)      :: 10 of 38
            Pseudo Genes (multiple problems)  :: 8 of 38
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 04:28:11
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3708764
            Orig. end                         :: 3731878
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP044545.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Jianguo Xu.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..23114
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="5"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..23114
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23114
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13114](-)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..13114)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     gene            497..3313
                     /locus_tag="F7984_RS17800"
                     /old_locus_tag="F7984_17800"
     CDS             497..3313
                     /EC_number="3.6.4.-"
                     /GO_function="GO:0004386 - helicase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018661145.1"
                     /locus_tag="F7984_RS17800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7984_17800"
                     /product="DEAD/DEAH box helicase"
                     /protein_id="WP_066105744.1"
                     /transl_table=11
                     /translation="MQLIETLHIQIELLEGGRVFIYGTDEGEPVPAELWATSFFLWDAD
                     SFFGTKLDIQTLDGKSGVLMSAHKWMKVLAEEPFNSFINWSWSNWASISLALAQSLYET
                     VENGTVMPDFNDRNQDGITFPLPQEILEDFQDSFWEQEMARHEHDGIQTITVRRFAEEW
                     LNEAIKDRPGNHRVGDLLDLFAEKNISTKVLSRFFDGDRWEIWTGAKEDELPFSMGMRL
                     SEPDFAAGDEVDQWKLEPFMRGKRNEEQFFIWADRHRIPFAWKRHLEMAEKEIARWKDI
                     FPWIDDIVTEDQAWDFLTDASEVLHMLGVEILLPSWWQAIKDAKIAMKAKVKNSPSRRK
                     SFVGMNALLDYNWRFSVNGAEVSEEEFNKLVEEKRKLVYIRGRWVKLDPALMRRMQELK
                     KEADERGLRINDLLQQEFAQDEELEDENEGDYARIQFELNSDLRRFMTRINSLQDIPTV
                     QVPDAFQGELRPYQQQGMSWLMFLREYGFGACLADDMGLGKTIQLISYLLAVEAKNGPA
                     KSPSLIVCPTSVLGNWQKEFEKFAPSMNVHLHYGPSRMKGEQFRDGFGNADVILTTFGL
                     LHQDEEDFLSMQWNAVVLDEAQNIKNSHTKQSRSARKLEGIHHIALTGTPMENRLSELW
                     SIFDFINKGYLGSLTQFDKNFAGPIERNGDKNKIATLQRLIQPFLLRRTKKDEEVALNL
                     PDKLEQKEFISLTTEQAALYEQLVKDTLDQVEKLSGFERKGLILQMLTKLKQICNHPAL
                     YLKEEAPKHILHRSGKMEKLIELLDIIYEQDESVLIFTQYIEMGNMIKQIAERRYGHVV
                     PFLNGSANKKQRDTMVADFQDGKYPILLLSLKAGGTGLNLTAANHVIHYDRWWNPAVEN
                     QATDRAYRIGQTRFVHVHKMVSSGTLEEKIDVMLEKKQSLNDEIVQSDNWITELSSDEL
                     KDLLVLER"
     misc_feature    539..548
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 17.14"
                     /tool="antismash"
     gene            3430..4041
                     /locus_tag="F7984_RS17805"
                     /old_locus_tag="F7984_17805"
     CDS             3430..4041
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="F7984_RS17805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="F7984_17805"
                     /product="hypothetical protein"
                     /protein_id="WP_192796825.1"
                     /transl_table=11
                     /translation="METEVRKLSFKEVVQTFEKTQELADAPLTYIAVICWTIIGIAIFY
                     HVIRDRRSLSSVAVGIRVISLAAVGFIAFHLYTNISEYDYSLDEEKWKQEYLLAYLDSQ
                     PEERLAIEQVEATNTDSDKAIPSMHLKKGSPTVHVKFLTIGKNGDKQEISTPVKIKHVQ
                     AETAPYLTYKTIEDELSNQYRDDMYYETTLYINQDSNLYK"
     gene            4291..4896
                     /locus_tag="F7984_RS17810"
                     /old_locus_tag="F7984_17810"
     CDS             4291..4896
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024458.3"
                     /locus_tag="F7984_RS17810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7984_17810"
                     /product="DUF3920 family protein"
                     /protein_id="WP_140461872.1"
                     /transl_table=11
                     /translation="MIVEENLSLESTLNRPSRLAKTVLRNHSNILSDFQLKQILNLLYD
                     DYKYLGMTISIYDHPDQVIADRTDYGKEFIDDWCYEDSLNGTLGGYHKLGKIALFPFNH
                     KVKNKKYERGLMQLFLLQDLFHEIRHAYQRVYMKRQYNTPYVNTGRNGYQSQWVERDAN
                     MFAQRMIEKHRNSINTILNIDFLWQSCWGRFYVTIVRQ"
     gene            complement(4934..5377)
                     /locus_tag="F7984_RS17815"
                     /old_locus_tag="F7984_17815"
     CDS             complement(4934..5377)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019721176.1"
                     /locus_tag="F7984_RS17815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7984_17815"
                     /product="CBS domain-containing protein"
                     /protein_id="WP_139892095.1"
                     /transl_table=11
                     /translation="MKAKDFMIKDVISLNEEASIKTLLEVLMKHKIGGLPLVDPNNKLL
                     GIVTDGDVLRYMNPKAFISSYVTYIEELDETLKSKSESPVKAIMKKKVVFVREEDELED
                     VLKLLATHHFKKIPVVNGNREVVGVISRGDMIRKLGELLLEKL"
     gene            <5490..5681
                     /locus_tag="F7984_RS17820"
                     /old_locus_tag="F7984_17820"
                     /pseudo=""
     CDS             <5490..5681
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003572096.1"
                     /locus_tag="F7984_RS17820"
                     /note="internal stop; incomplete; partial in the middle of
                     a contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="F7984_17820"
                     /product="IS1595 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="SWNIKLINK"
     gene            5721..6041
                     /locus_tag="F7984_RS17825"
                     /old_locus_tag="F7984_17825"
     CDS             5721..6041
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012514.3"
                     /locus_tag="F7984_RS17825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7984_17825"
                     /product="NUDIX domain-containing protein"
                     /protein_id="WP_308810542.1"
                     /transl_table=11
                     /translation="MRNRSSVVIIENMKVVLIQRIRDGSIYYVFPGRGIENGETPEAGA
                     KREALEDLGVEVKVNECISAVEFNGNQYFLLSEIISGTFGTGQGEEYIEKIEIEERTCQ
                     CG"
     gene            complement(6347..8521)
                     /locus_tag="F7984_RS17830"
                     /old_locus_tag="F7984_17830"
     CDS             complement(6347..8521)
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012869.3"
                     /locus_tag="F7984_RS17830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7984_17830"
                     /product="peptidase domain-containing ABC transporter"
                     /protein_id="WP_140461873.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 3.7e-37, bitscore:
                     124.9, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPKKVPYIAQMEHSECGLACLAMLLKFYDHHLTLAELRDEYGSSS
                     NGYSFLDLYRIATAKEMVVKAYHIDMNSNKLSETNFSKIGFPLILHWEMSHFVVLEKVN
                     KKYFFIVDPSSGRKKLNKEEFLSSFSGSILYCKPNEKFKKKPAQRQTIIYHYLRSEKKF
                     ITLAIFVTFLIQLIAMGIPILTQQFTDRVLVNATNQFMYISGFALASIFFSYIIISNIR
                     GYLIARLQSKLDLFLMSRFMTVLFKLPFLYFNNRTSGDLLFRANSNALIKQLLSTTGIS
                     VVIDILLVFSYSVIMFQYSVQLSLILLIIGLVIIGFLVVNTKVIQKLSDQNVSIQSEVQ
                     SILADSIHGIIDVKMLGLENKLFNTWYKKFTNQVTINQKLNLWNSFIQSFTSAIQMIVP
                     LFMLWIGSIALNNGELTLGALLAFSTISVSFIQPIVSLSSSYTQILSIGSYFQRIIDVI
                     DTKIEESKDQRNSITGVVEFKKVSFQYSKFSQEVISDFSLKIKKGETVAIVGPSGSGKS
                     TVAKLLLGFYRPTDGHILIDSINLEDYDKNHLRKNISTVLQESRLFNKTIYENISMFQE
                     DVTIQEVINACKEANIYDDIMKLPLNFHTKISEDGNNFSGGQKQRLLIARALVNKAPIL
                     LLDEASSSLDSISEQIIHENLAEISGTKIIIAHRLSTVENADRIIVLSEGKLKEEGTHA
                     ELIRAKGLYHRLYHSQNNILLTADHAMTPS"
     gene            complement(8567..8974)
                     /locus_tag="F7984_RS17835"
                     /old_locus_tag="F7984_17835"
     CDS             complement(8567..8974)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="F7984_RS17835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="F7984_17835"
                     /product="hypothetical protein"
                     /protein_id="WP_140461874.1"
                     /transl_table=11
                     /translation="MKRSKYTLGISGAFLILLVIILRFTTGLDIISSDLIFIGLGLLGA
                     ILLAMALSVDLDRYKSEEQLIEENDERNNLISMKAKSKVLNLVLTLFPLSLLILATMGF
                     MNKISFFSMVIVIFFTVGYYLFQVSQEGKKI"
     gene            complement(8971..9174)
                     /locus_tag="F7984_RS17840"
                     /old_locus_tag="F7984_17840"
     CDS             complement(8971..9174)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008787624.1"
                     /locus_tag="F7984_RS17840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7984_17840"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_140461875.1"
                     /transl_table=11
                     /translation="MKNDLETMRKQRGLRQEELGRILKVSRQTIGSIENGKYNPSLILA
                     FKIAQYFDVKIEDIFYYEEASE"
     misc_feature    complement(9207..9223)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 23.99"
                     /tool="antismash"
     misc_feature    9218..9232
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 23.18"
                     /tool="antismash"
     gene            complement(9271..9981)
                     /locus_tag="F7984_RS17845"
                     /old_locus_tag="F7984_17845"
     CDS             complement(9271..9981)
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002016769.1"
                     /locus_tag="F7984_RS17845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7984_17845"
                     /product="flavodoxin family protein"
                     /protein_id="WP_140461876.1"
                     /transl_table=11
                     /translation="MKKVFVYIGSRNDNSILYTYLNRLIENISLQDESIKFTIYKAYET
                     NIFHSTGCKSCFTKGKCPQDQLHNDRMEEIKRELLESDFVILASPVYSHNVSGDMKAFI
                     DRLSYWGHLFRLAGKPGLVVASGGNGLNHVLDYLEKVSTYMGIITIGRVSAISGAEIKE
                     EDIANNTHAILKHLKEEIVTESNDALEAAFLSFKWIYENYPEDHVEHIYWRENGFFECD
                     SFQEVLDKKVKILK"
     misc_feature    9941..9955
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: medium, score: 22.73"
                     /tool="antismash"
     gene            complement(10001..13114)
                     /locus_tag="F7984_RS17850"
                     /old_locus_tag="F7984_17850"
     CDS             complement(10001..13114)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03897.1"
                     /locus_tag="F7984_RS17850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7984_17850"
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_140461877.1"
                     /sec_met_domain="DUF4135 (E-value: 5.6e-96, bitscore:
                     319.7, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 1.9e-64, bitscore:
                     215.5, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLVKREILPINYLNSLWIKEKYPLYQNSSTSLSEKEYKAWRNRKN
                     IVSDESFSLMLSEWNYEEEIFSNCLMRNEEDKTGEICEYLLKAEWFQLYKEAIELVEVN
                     NTKYDSNLGFSYILRPFTLFLGNKLSKFIESKDVFRYFDLDTLMAGFIDSLGQIAHKSL
                     VLELNVSRLRNELTGTSSEERFHSFNERFYDLDILIAFYEEYQVLSRILATKTLFFYKN
                     TIEFIDRFLLHKEEIYSKFNLSSNDFIKTITFGEGDSHQQGRNVFRIEFESTKHLFYKP
                     RNTDIGNAYQDYLNWINQYEDVLEMATYRILGYKDYSFEEIVEKKGCDSEEEVRNFYIR
                     FGQLLAIVYSLNGTDMHMENIIASGSNPIIVDFETLLHNSILFNWSDSAYVNASYEAQE
                     LVSSTMLLPIEIKENLLNDSGIDMSGLNGKSQKLPYKVPGPININSDEMKYGLIEWTTK
                     GANNLPELNGQPIDYTNYIEEIIKGFKVVYSVILANRDSLLKETKVLSNFNKLKVRIIP
                     RGTTQYFNMINNTYHPDYLRHALDREQVIENIWSVPYQAKSIIKSEYEDLLNDDIPIFF
                     NYTNSKDLIDSTGKIYRDVYKSTGYSLLLDKINKMNAEDMEKQVSVIVVKTGMYEKLIQ
                     NEEKKGKSCTIKDSIKKVDVNNIDNDIFVNEAKAIGDHILSKAIYSENGETVSWLGINV
                     VKDSFDITPITSDFYDGLSGLFHFYYYLHQITKEDRYEDIYRKLLNSAEERMVVLDDYS
                     IFTGQLSLLYPLAKISYQIKGDSKWKDRLLKLLKLGEDNLDNFIGYDWMSGTTGFLHCV
                     INIFEESKDPEILALCIKLANKLIRQLDSTDRLLGGFAHGSSSVAYVLIRLGTITKSKK
                     FLEKGKSLLEFDQSLFSEGCNGWLDISTDDNICRHQWCHGTEGIGISRLLISQFINDER
                     TNTEIEKALDITLNSPYKSDDCLCHGNMGTTELFLHASQIKNDKSYETIAKSLALKVIQ
                     ESKERGSYKDRSIPGFRSVGMFTGIAGIGYQLLRIANPESVPSVLSFN"
     gene            complement(13204..13434)
                     /locus_tag="F7984_RS17855"
                     /old_locus_tag="F7984_17855"
     CDS             complement(13204..13434)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="F7984_RS17855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="F7984_17855"
                     /product="bacteriocin leader domain-containing protein"
                     /protein_id="WP_140461878.1"
                     /transl_table=11
                     /translation="MSSEEIIMRWKNPELRDGTSISHPSGLGFQELDLKEISSVCGGNG
                     EIQPQGTPAATVISALASFVGSYLVTAVFCK"
     CDS_motif       complement(13306..13434)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MSSEEIIMRWKNPELRDGTSISHPSGLGFQELDLKEISSVCGG"
                     /locus_tag="F7984_RS17855_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(13204..13305)
                     /prepeptide="core"
                     /locus_tag="F7984_RS17855_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-3.00"
                     /molecular_weight="3232.7"
                     /monoisotopic_mass="3230.7"
                     /core_sequence="NGEIQPQGTPAATVISALASFVGSYLVTAVFCK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSSEEIIMRWKNPELRDGTSISHPSGLGFQELDLKEISSVC
                     GG"
                     /leader_location="[13305:13434](-)"
                     /alternative_weights="3250.7"
                     /alternative_weights="3268.7"
                     /alternative_weights="3286.7"
                     /alternative_weights="3304.8"
                     /alternative_weights="3322.8"
     gene            complement(13626..13907)
                     /locus_tag="F7984_RS17860"
                     /old_locus_tag="F7984_17860"
     CDS             complement(13626..13907)
                     /GO_process="GO:0050830 - defense response to Gram-positive
                     bacterium [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR03893.1"
                     /locus_tag="F7984_RS17860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7984_17860"
                     /product="mersacidin family lantibiotic"
                     /protein_id="WP_140461879.1"
                     /transl_table=11
                     /translation="MTNEQKIMMWKNPAMRKEMELSNEHPCGKGFQELSLDEMIGVNGA
                     SEYTPNAITTPVCVVTIPVSVKYCVPATISATASAISGIVTFNKGCLG"
     misc_feature    14244..14257
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.41"
                     /tool="antismash"
     gene            complement(15176..15364)
                     /locus_tag="F7984_RS17865"
                     /old_locus_tag="F7984_17865"
     CDS             complement(15176..15364)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="F7984_RS17865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="F7984_17865"
                     /product="hypothetical protein"
                     /protein_id="WP_066105730.1"
                     /transl_table=11
                     /translation="MNEREVVADLIRIVGSVNSRVSKSESDLRKIEQTLQILIKELSNM
                     KELQYQLCEQTYQLHEH"
     CDS_motif       complement(15317..15364)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MNEREVVADLIRIVGS"
                     /locus_tag="F7984_RS17865_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(15176..15316)
                     /prepeptide="core"
                     /locus_tag="F7984_RS17865_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.90"
                     /molecular_weight="5406.1"
                     /monoisotopic_mass="5402.8"
                     /core_sequence="VNSRVSKSESDLRKIEQTLQILIKELSNMKELQYQLCEQTYQL
                     HEH"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MNEREVVADLIRIVGS"
                     /leader_location="[15316:15364](-)"
                     /alternative_weights="5424.1"
                     /alternative_weights="5442.1"
                     /alternative_weights="5460.1"
                     /alternative_weights="5478.2"
                     /alternative_weights="5496.2"
                     /alternative_weights="5514.2"
     gene            complement(15361..15735)
                     /gene="ssb"
                     /locus_tag="F7984_RS17870"
                     /old_locus_tag="F7984_17870"
     CDS             complement(15361..15735)
                     /GO_function="GO:0003697 - single-stranded DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006260 - DNA replication [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /GO_process="GO:0006351 - DNA-templated transcription
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ssb"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018661149.1"
                     /locus_tag="F7984_RS17870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7984_17870"
                     /product="single-stranded DNA-binding protein"
                     /protein_id="WP_140461880.1"
                     /transl_table=11
                     /translation="MLNQVALVGRLTKDPDLRYTPEGKAVSNITLAVTRNFKNADGEYG
                     TDFVNCTIWNRAAENTASYCQKGSVVSIVGRIHTRNYENPEGKRTYVTEVIVESVNFLD
                     RKRVNNLHEGSLETNAVPIL"
     misc_feature    complement(15892..15907)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.55"
                     /tool="antismash"
     gene            15995..16405
                     /locus_tag="F7984_RS17875"
                     /old_locus_tag="F7984_17875"
     CDS             15995..16405
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025546.3"
                     /locus_tag="F7984_RS17875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7984_17875"
                     /product="YwpF family protein"
                     /protein_id="WP_139892094.1"
                     /transl_table=11
                     /translation="MKTFKLVSLQLLPDNQHPTELHILDGLIINKENEANTWLIEAVVD
                     YEHFNLFKEITADTDKLTVSCIITKKDNIPAYFDATIADVRKMDQFASILFRAKIRNRR
                     REAVEFLLDTLVDEGYNGEDLKNAFKEGLGNK"
     gene            complement(16440..16826)
                     /locus_tag="F7984_RS17880"
                     /old_locus_tag="F7984_17880"
     CDS             complement(16440..16826)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="F7984_RS17880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="F7984_17880"
                     /product="hypothetical protein"
                     /protein_id="WP_140461881.1"
                     /transl_table=11
                     /translation="MQKFYKAIMGVALASVLMVGCNNNDDNNPPPERNNNQEQNNGTND
                     NNGIDTNESTKDNNGMNGNNNNNGNGINGNDDNNGMNDTNDNGQDSELDTDVREDGDRI
                     RNDADRGADDILDNNNNNGKDKNK"
     misc_feature    17074..17092
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 23.85"
                     /tool="antismash"
     gene            17199..18251
                     /locus_tag="F7984_RS17885"
                     /old_locus_tag="F7984_17885"
     CDS             17199..18251
                     /NRPS_PKS="Domain: PKS_KR (25-136). E-value: 4.8e-08.
                     Score: 25.1. Matches aSDomain:
                     nrpspksdomains_F7984_RS17885_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019716296.1"
                     /locus_tag="F7984_RS17885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7984_17885"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_140461882.1"
                     /sec_met_domain="adh_short (E-value: 9.4e-30, bitscore:
                     101.7, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDIKKVEQMKDQSMKRLHLKDLKDQVIVITGASSGIGLVTARMAA
                     EKGAKVVVAARNKDALQELVYELKSKGHEAVWVAADVGVEEDVLKIAETAILNYGGFDT
                     WVNNAGVSIYGTTTEVSIKDMRRMFDTVFWGVVYGSRIAVEHYKTRGGPGAIINIGSFF
                     GDRGTVIQSTYSSAKFALHGWTENLRMELEKENAPISVTLIHPGRIDTPYNEHARSYLE
                     KQPTHIGMIYAPETVAEAILFAAEHPKRDMYVGSQAKFLAMLGRFAPRFTDKFVEKTMY
                     HTQHDDRPSNPPEDSALYKAGYGLHERGTNKGWIRETSYYVKASKHPVLTSVLVAGIGA
                     CLLATFMQNK"
     aSDomain        17274..17606
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_F7984_RS17885_PKS_KR.1"
                     /evalue="4.80E-08"
                     /label="F7984_RS17885_PKS_KR.1"
                     /locus_tag="F7984_RS17885"
                     /protein_end="136"
                     /protein_start="25"
                     /score="25.1"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VIVITGASSGIGLVTARMAAEKGAKVVVAARNKDALQELVYELKS
                     KGHEAVWVAADVGVEEDVLKIAETAILNYGGFDTWVNNAGVSIYGTTTEVSIKDMRRMF
                     DTVFWGV"
     CDS_motif       17277..17357
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_F7984_RS17885_0001"
                     /evalue="6.10E-06"
                     /label="PKSI-KR_m1"
                     /locus_tag="F7984_RS17885"
                     /protein_end="53"
                     /protein_start="26"
                     /score="18.9"
                     /tool="antismash"
                     /translation="IVITGASSGIGLVTARMAAEKGAKVVV"
     gene            complement(18329..18763)
                     /gene="fabZ"
                     /locus_tag="F7984_RS17890"
                     /old_locus_tag="F7984_17890"
     CDS             complement(18329..18763)
                     /EC_number="4.2.1.59"
                     /codon_start=1
                     /gene="fabZ"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1270: UDP-3-O-[3-hydroxymyristoyl]
                     N-acetylglucosamine"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014457771.1"
                     /locus_tag="F7984_RS17890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7984_17890"
                     /product="3-hydroxyacyl-ACP dehydratase FabZ"
                     /protein_id="WP_140461883.1"
                     /transl_table=11
                     /translation="MLDVQQIKEIIPHRYPFLLVDQILEVDEGKRAVGVKNVTANEEFF
                     NGHFPDYPVMPGVLIVEALAQVGAVAVLIKEENKGRLAFFAGIDKCRFKRQVRPGDQLR
                     LEVELTRVRGPIGKGIGRATVNGELACEAEITFALGDEKS"
     CDS             complement(18972..19193)
                     /gene="allorf_3727736_3727957"
                     /locus_tag="allorf_3727736_3727957"
                     /protein_id="allorf_3727736_3727957"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MLVAGLQDVGHEDVAKGRGAFSLRSLNKALQLYSVIQLRRLEAQD
                     ISMTSAGGRTPPSDVLSYAPREPTGCRS"
     CDS_motif       complement(19035..19193)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MLVAGLQDVGHEDVAKGRGAFSLRSLNKALQLYSVIQLRRLEAQDISMTSAGG"
                     /locus_tag="allorf_3727736_3727957_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(18972..19034)
                     /prepeptide="core"
                     /locus_tag="allorf_3727736_3727957_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-1.70"
                     /molecular_weight="2099.3"
                     /monoisotopic_mass="2098.1"
                     /core_sequence="RTPPSDVLSYAPREPTGCRS"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MLVAGLQDVGHEDVAKGRGAFSLRSLNKALQLYSVIQLRRL
                     EAQDISMTSAGG"
                     /leader_location="[19034:19193](-)"
                     /alternative_weights="2117.3"
                     /alternative_weights="2135.3"
                     /alternative_weights="2153.4"
                     /alternative_weights="2171.4"
     misc_feature    complement(19330..19342)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.11"
                     /tool="antismash"
     gene            complement(19468..19755)
                     /locus_tag="F7984_RS17895"
                     /old_locus_tag="F7984_17895"
     CDS             complement(19468..19755)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009792673.1"
                     /locus_tag="F7984_RS17895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7984_17895"
                     /product="DNA-directed RNA polymerase subunit beta"
                     /protein_id="WP_066105709.1"
                     /transl_table=11
                     /translation="MQALVNNKSEQTESEPNSRIDRKKLGNDQKIKIRLVPLWARIIIV
                     LVLTMMALVGGAMVGYSVMGDGKAMDVFKKSTWTHIVDLVNKDTTENKDK"
     gene            complement(19768..20613)
                     /locus_tag="F7984_RS17900"
                     /old_locus_tag="F7984_17900"
     CDS             complement(19768..20613)
                     /GO_process="GO:0071973 - bacterial-type
                     flagellum-dependent cell motility [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019380643.1"
                     /locus_tag="F7984_RS17900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7984_17900"
                     /product="flagellar hook-basal body protein"
                     /protein_id="WP_140461884.1"
                     /transl_table=11
                     /translation="MNRMMITSSNTMGQLQKKLETVSNNISNTSTTGFKRKDTYFSDML
                     AQEFNNQERTEKEKGRLTPNGIRVGVGAKMIQSQLNLAQGNLQKTERDLDVALTNENLF
                     FAIRTADGTSSQLGYTRDGAFYLSPASDGSNHVQLVTSNGSAVLDENNQEIRINGNPSD
                     ITFTDKGQLNVATENGMQSFNLGIISVKKPQFMEMINNNTFTLPKNMAQLDVSENDIYT
                     QLTGAFRDEISMVQGNLEQSNVDISTEMTEMMQTQRLYQFQSRTVSMADQMMGLVNGIR
                     "
     gene            complement(20651..21484)
                     /locus_tag="F7984_RS17905"
                     /old_locus_tag="F7984_17905"
     CDS             complement(20651..21484)
                     /GO_process="GO:0071973 - bacterial-type
                     flagellum-dependent cell motility [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016204806.1"
                     /locus_tag="F7984_RS17905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7984_17905"
                     /product="flagellar hook-basal body protein"
                     /protein_id="WP_140461885.1"
                     /transl_table=11
                     /translation="MFKGFYTAASGMLAQQRKTELLANNLANANTVGYKEDQASVRSFP
                     EMLLSSYEKVNLPVEESVSINHSKYVGALNTGVYVQETIPSFSQGDVKTTDNTTDMAIV
                     DQAMPIDPERNQPGTALFTVETPDGLRYTRNGNFTLDGSGYLTTANGYYVLDENRERIL
                     LNSENFAISSQGEISEGTLNRGRIGISFSATPTAQLIKEGDGLYRINEGELPSAYTLNN
                     VQFAVQQGSIEQSNVDSSKTMTDMMAAYRTFEANQKIVQAYDQSMQKTVNEIGKL"
     misc_feature    complement(21448..21461)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: medium, score:
                     16.54"
                     /tool="antismash"
     CDS             complement(21897..22070)
                     /gene="allorf_3730661_3730834"
                     /locus_tag="allorf_3730661_3730834"
                     /protein_id="allorf_3730661_3730834"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MKGRGKQVWSTYALAMRYLYPGKGRSKVGERQRKAGMVHLCPGYE
                     APIPGYRSVKGR"
     CDS_motif       complement(21960..22070)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MKGRGKQVWSTYALAMRYLYPGKGRSKVGERQRKAGM"
                     /locus_tag="allorf_3730661_3730834_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(21897..21959)
                     /prepeptide="core"
                     /locus_tag="allorf_3730661_3730834_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-4.20"
                     /molecular_weight="2181.5"
                     /monoisotopic_mass="2180.1"
                     /core_sequence="VHLCPGYEAPIPGYRSVKGR"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKGRGKQVWSTYALAMRYLYPGKGRSKVGERQRKAGM"
                     /leader_location="[21959:22070](-)"
ORIGIN
        1 gcttacttac atgattatca gactcaggag tataagagaa ctcgattttt atataatgcc
       61 ctgcaaatta ttcgtccttt ttgctcagcc gccaaacgat tcgacttgca agagcgtatt
      121 ctaagagaaa ctatccctta ctcccttatt ccatattcac actatttgta tgagaagaag
      181 gagtataaaa aatgggtcga gctccaggtt gctgagcgtg tggatgtcct ttatgaatgg
      241 tccaatcaaa cgaaggaaat tcaaaaggaa cagcctgaag tcctccttcc tattctgcat
      301 ctgcaggtag ttaatttgat tgcggctaaa aatcgttcat cctaccggga agcggtccgt
      361 tatttaaaaa agctgagaac tatttataaa aaacttaagc gcgtaaacgt ttgggaatct
      421 tatattgaat acatcagcga cgataataaa cgattacgcg cttttcagga agaactaaag
      481 aaaggaaagt taattgatgc agctgattga aactcttcat attcaaattg aattacttga
      541 aggcggacgc gtctttattt atggaacgga cgagggtgag cccgttcctg ccgaattgtg
      601 ggcaacaagc ttctttcttt gggacgcgga tagtttcttt gggaccaaat tggatatcca
      661 aacactggat ggtaaaagcg gtgtcctcat gagcgcccat aaatggatga aggtgctggc
      721 agaagagcct ttcaatagct ttattaattg gtcctggtcc aattgggcat ccattagttt
      781 agctttggcc caatccttat atgaaaccgt tgaaaacgga acggttatgc ctgattttaa
      841 cgatcggaat caagacggca ttaccttccc gctcccacag gaaattctcg aagactttca
      901 ggactccttt tgggaacagg aaatggccag acacgagcat gacggaatcc aaaccataac
      961 ggttcggcgc tttgcggagg aatggttaaa tgaagcgatt aaagaccgtc ccggcaatca
     1021 tcgcgtaggt gatttgcttg atttgtttgc tgaaaaaaat atctccacca aggtactcag
     1081 ccgcttcttt gacggagacc gttgggaaat atggaccggt gctaaagaag atgaattgcc
     1141 tttttctatg ggaatgcgcc tgagcgagcc tgattttgca gcgggtgatg aggttgacca
     1201 atggaagcta gaaccgttta tgcgcggcaa gcgaaatgag gagcaatttt tcatatgggc
     1261 tgatcgccat aggattcctt ttgcctggaa aaggcattta gagatggctg aaaaggaaat
     1321 cgcccgctgg aaggatattt tcccttggat tgatgatatt gtcactgagg atcaggcctg
     1381 ggatttctta acggatgctt ccgaggtcct acatatgctt ggcgtagaaa ttctattgcc
     1441 atcatggtgg caggcaatta aggatgcgaa aatcgccatg aaggctaaag tgaaaaattc
     1501 gccaagccgc cgaaaatcat ttgtgggtat gaatgccttg ctcgattata attggcgttt
     1561 ctccgtcaat ggcgctgagg tttccgagga ggaatttaac aagcttgttg aggaaaaacg
     1621 gaagcttgtc tatattagag gacgctgggt gaaactggat cctgccttaa tgaggcgcat
     1681 gcaggaattg aagaaggaag cagatgagcg aggattgcgt atcaatgatt tacttcagca
     1741 ggagttcgca caggatgagg agcttgagga tgagaatgaa ggggattacg cacgaattca
     1801 atttgagctg aatagtgacc tgagacgctt tatgactcgc atcaactcac ttcaggatat
     1861 cccgactgtc caggtacccg atgccttcca gggcgaattg cggccgtatc agcaacaggg
     1921 aatgagctgg ctgatgttct tacgtgaata tggattcggt gcctgtctgg ccgatgatat
     1981 gggtctaggg aaaacgattc agctcatcag ctatctgtta gcggtggagg cgaagaatgg
     2041 tccagcaaaa tctccatcct tgattgtctg tccgacttct gtgctcggaa actggcagaa
     2101 ggagtttgaa aagttcgctc catctatgaa cgtccatctt cactatggtc caagtcgtat
     2161 gaagggtgaa cagtttaggg atgggtttgg caatgccgat gtgattctga caacctttgg
     2221 gttgcttcat caggatgagg aagacttttt atccatgcaa tggaatgctg ttgtgctcga
     2281 cgaagcgcag aatatcaaga attcccatac gaagcaatcc cgttctgccc gtaagcttga
     2341 aggcattcat catatcgcct taaccggtac tccaatggaa aatagactga gtgagctttg
     2401 gtccattttt gattttatta ataagggcta tcttggctca ctaacgcaat ttgataaaaa
     2461 ctttgccgga ccgattgaac gcaatggtga taagaataaa attgccaccc tgcaaaggct
     2521 aattcagcct ttccttttaa gaaggacgaa aaaggatgaa gaggttgctc tcaatctgcc
     2581 ggataaattg gagcaaaagg agtttatcag cctaacaacc gagcaagccg ctttatacga
     2641 acagcttgtt aaagatacgc ttgatcaagt tgaaaaacta agcggtttcg aacggaaagg
     2701 gcttattttg cagatgctaa ccaagctgaa gcaaatctgt aatcatcctg ccctttatct
     2761 aaaggaagag gcaccaaagc atattcttca tagatccggg aaaatggaaa agctaattga
     2821 attgctcgat atcatttatg aacaggatga aagtgtgctt atttttacac aatacattga
     2881 aatgggtaat atgattaagc aaatcgctga gcgccgctat ggtcatgtcg ttccattcct
     2941 gaacggcagc gccaataaaa aacaacggga taccatggtg gccgattttc aggatggcaa
     3001 gtatccgatt cttctacttt ccctgaaagc gggcggtaca gggcttaacc tgacggctgc
     3061 caaccatgtc attcactatg accgctggtg gaatccagct gttgaaaatc aggcgaccga
     3121 ccgtgcctac cgtattgggc aaacgcgctt tgtacatgtc cataagatgg tttcctccgg
     3181 tacacttgag gagaaaattg acgttatgct ggagaaaaaa caatcgctta acgatgaaat
     3241 cgtccaaagt gacaattgga ttaccgagct atcctcagat gaattaaagg atttgctggt
     3301 gcttgaaaga taactttttg gccatcccct tcttaaaaaa taggggatgg cttttttgta
     3361 tctattagag tcggaataat aaaaattgat taaacaaata aaataattta cagttattag
     3421 taaaaggaaa tggaaacaga ggtgagaaaa ctgagtttta aagaggttgt acaaactttt
     3481 gagaagacac aagagttagc tgatgcaccg ctcacgtata ttgcggtgat ctgttggaca
     3541 atcattggaa tagctatttt ctatcatgtc atacgtgatc ggagatcttt atccagtgtt
     3601 gcggttggta taagagtgat ttccttggcc gcagttggct tcattgcgtt tcacttatat
     3661 acgaatatct ctgaatatga ttattcactc gatgaggaaa aatggaaaca agaatattta
     3721 cttgcttatt tagattcaca gcctgaggag aggctggcca ttgaacaggt agaggcaacg
     3781 aatacagata gtgacaaggc aattccttca atgcatctaa aaaagggatc acctaccgta
     3841 cacgtgaaat ttttaacgat cggaaagaat ggcgacaagc aggagatttc tactccagta
     3901 aagattaaac acgtacaggc agaaaccgct ccatatctca cctataaaac tattgaagat
     3961 gaattatcca atcaatatag agatgatatg tactatgaaa cgactctata tatcaatcaa
     4021 gatagcaatt tgtataagta aggaaagggg tctctcctct ttcctttttt aagcaattta
     4081 tttacttacc ctcttttaaa taatgtcaaa ccacttattt gacgaaattt gctcttcgtt
     4141 gtatactttt ctacattatt ccttcttttt ccacattttt atatccattt atgtagtaat
     4201 ttgttgcgaa tgtatagtca cggtcctggc atatcatgtt atatgcccaa ttaaaacagc
     4261 cagattaatt aacaggagtt gcttacatta atgatcgtag aagaaaacct ctctcttgaa
     4321 agtaccttaa atcgcccctc cagattagcg aaaacagttt tacgtaatca ttcaaatatc
     4381 ctatcagatt tccagcttaa acaaatactc aatttacttt atgacgatta taaatactta
     4441 ggaatgacca tttccatata cgatcatcca gatcaagtca tcgcagaccg taccgattat
     4501 ggaaaggaat ttattgatga ttggtgttat gaggattctt taaatggcac attgggcgga
     4561 taccataagc ttggtaagat tgcattattt ccctttaacc ataaggtaaa aaacaaaaaa
     4621 tacgagcgcg ggcttatgca gctgttttta ctacaggatc tctttcatga aattcgccat
     4681 gcctaccagc gtgtctatat gaagaggcag tataatacgc cttatgtcaa cacaggcaga
     4741 aatggctatc aatcacaatg ggttgaacgg gatgctaaca tgtttgccca aaggatgatt
     4801 gagaagcatc gcaactctat caacaccatt ttaaatatcg acttcttatg gcaaagctgc
     4861 tggggacgtt tttacgtaac aattgtacgc caatagaaat aaaaaggaga ctcaggaatg
     4921 agcctccttt ctcttacaat ttttcaagta gtaactcgcc taatttacga atcatatccc
     4981 cacggctaat tacacccaca acctcacgat ttccattgac tacaggtatc tttttgaagt
     5041 ggtgtgttgc cagcagcttg agtacatctt caagctcatc ctcttctcga acaaagacta
     5101 cttttttctt cataatagct ttaaccggag attcactttt tgattttaag gtttcatcca
     5161 actcttctat ataagtgaca taagaggaaa tgaaggcttt tgggttcata tatctcagga
     5221 catccccatc tgttacgatc cccaacagtt tattgtttgg atcgaccaga ggaagtcctc
     5281 cgattttatg tttcattaaa acttccagca atgttttaat acttgcctct tcatttaaac
     5341 taattacatc cttgatcatg aaatcctttg ctttcacctt aaatccctcc tggctgtaat
     5401 aagaaaatat gtatctaccg ttatcttacc aataatttca attctatttc taatagaaaa
     5461 aatatctttt caaaaataga gcttgctgaa gttggaatat taaattaata aataaatgag
     5521 atcggttcaa tggcgtggca acgaagtacc ttgaccatta tttgagctgg ttacagtttc
     5581 taaaccaaat caaacaccgt aatgttgata caactgtcag taagatgatt attgaaagct
     5641 gtatgttctt aacggaaatg acctatgata aactcgggta attaaaattt tccaaattat
     5701 gaacgatagg ggaatcatct atgagaaata gaagctcggt ggtaataata gagaatatga
     5761 aggttgtttt aattcaaaga attagggatg gttctattta ttatgttttc cctggtcgtg
     5821 gaatagagaa tggtgaaaca ccagaagctg gagctaaaag agaagcatta gaggatttag
     5881 gggttgaagt aaaagttaat gagtgcattt cagcagttga attcaacgga aatcaatact
     5941 ttttactgtc tgaaattatt tctggaactt ttggaactgg acaaggtgaa gaatacatag
     6001 aaaaaataga gatagaggaa cgtacttgcc aatgtgggta gatatagaaa gtttatcatc
     6061 tattgatgta agaccgaatg aagttgcttt aaaggttcaa tccctattaa attaataact
     6121 caaaacaagg gaactcccag agaatatggg ttcccccttt caaaatcgca aaaatcaata
     6181 ttattcttta acatagcttt aattaaaaaa acaatccccc cgaaaaaact acggatgtat
     6241 atctttataa aattccaaaa aattttcagg gacttaccat tttcgttttc cacttgtatt
     6301 tttatccata atataagtag gttagcattc atagaaaaga attttattaa ctcggggtca
     6361 ttgcatgatc ggcagttaat aatatattat tttgtgaatg atataatcga tgatataatc
     6421 cttttgctct aattaattct gcatgtgtac cttcttcttt cagtttacct tcagaaagaa
     6481 caataatgcg atcagcattc tctaccgtac ttaacctatg agcaattatt attttggtac
     6541 ctgaaatctc ggccaaattt tcatgtataa tttgttcaga tattgaatct agagaactgg
     6601 atgcttcatc aagcaacagg atgggtgcct tattaaccaa agctcgagct attaataatc
     6661 tctgcttttg tccacctgaa aagttgtttc catcttcaga aattttagta tggaaattca
     6721 aaggcaattt cattatatcg tcatatatat tagcttcttt acaagcattg attacttcct
     6781 gtatggtaac atcctcttga aacatactta tattttcata tattgtttta ttgaatagtc
     6841 ttgactcttg taaaacagtt gaaatatttt ttctcaaatg atttttatca taatcttcaa
     6901 gatttatact atctattagt atatggccat ctgtaggtct ataaaagcct aataataatt
     6961 ttgcaacggt acttttacct gaacctgatg gaccaacaat tgcaactgtc tctccttttt
     7021 ttatttttag tgagaagtct gaaatcacct cttgactgaa ctttgaatac tgaaaagaaa
     7081 cttttttaaa ttcaaccaca cctgttatag agtttcgttg gtctttactc tcctctatct
     7141 tagtatcaat tacatcaata atcctttgaa aatatgaacc aattgataag atttgtgtat
     7201 aggagctact taaagagaca ataggttgaa taaaagaaac agaaattgta ctaaaggcta
     7261 ataaggcacc taaagtcaat tccccattat tcagagcaat acttccaatc cagagcataa
     7321 ataaaggaac aatcatttgt attgctgatg tgaatgactg tataaaacta ttccataggt
     7381 ttaatttttg attaatagtg acttgattag taaacttttt ataccaggta ttaaatagtt
     7441 tgttttctaa ccctaacatt ttaacatcta ttattccatg gatactgtca gctaaaatag
     7501 attgaacttc tgattgaata gatacgtttt gatctgaaag tttttgaatt acttttgtat
     7561 taacaacgag aaatccaata ataaccaggc cgataataag taagattaaa cttaattgaa
     7621 ctgagtattg aaacataata acggagtaac taaaaaccaa gagaatatca ataactactg
     7681 aaatacccgt agttgacaaa agttgtttaa ttaatgcatt tgaattagcc ctaaataata
     7741 ggtctccgct tgttctatta ttgaagtata agaagggcag tttgaataag actgtcataa
     7801 atcgggacat aagaaataaa tctaatttac tttgtaaccg cgcaattaaa tatcccctta
     7861 tatttgatat tataatatac gaaaaaaata tagacgctaa ggcgaagcct gaaatataca
     7921 taaactgatt cgtagcattt actaatactc tatcagtaaa ttgttgtgtt aaaatgggga
     7981 tacccattgc aataagttga attaaaaatg tgacgaaaat tgctaacgtg atgaacttct
     8041 tttcggagcg taaatagtgg tatataatcg tttgtctttg tgcaggtttt tttttaaatt
     8101 tttcatttgg tttacaatat aaaatactac ctgaaaaaga agaaaggaat tcctccttat
     8161 taagcttttt tcttccagat gagggatcta ctatgaagaa atatttttta tttactttct
     8221 ccagaactac gaaatggctc atttcccaat gaagtattaa aggaaaacca atcttagaaa
     8281 aatttgtttc gcttaattta ttgctgttca tatcaatatg atatgcctta acaaccatct
     8341 ctttggctgt tgcaattcgg tataagtcta aaaaagagta accattagaa gaagagccat
     8401 attcatctcg taattcagct aaggttagat gatggtcata aaatttcaat agcatagcta
     8461 aacaagctaa tccacattca ctatgttcca tctgagcaat gtacggaact tttttaggca
     8521 taattatctc cttatgaaat cttactttac tttcttatag ttttatttat attttctttc
     8581 cctcttgtga aacttgaaac agatagtacc ccacagtgaa aaagattaca ataaccatac
     8641 taaagaatga tatcttattc ataaatccca tagttgctag tattaacaaa cttaaaggga
     8701 acaaagtaag gactaaattt aacacttttg atttagcttt catactaata aggttatttc
     8761 tctcatcatt ttcttcgatt aattgttctt ctgacttata cctatccaag tcaacggata
     8821 atgccatagc aagtaaaata gcacctagta gacctaaacc aatgaatatt aaatctgaac
     8881 taataatatc taatcctgtt gtaaatctta atataatcac caataagatt aaaaaggctc
     8941 cacttatccc aagagtatac ttacttcttt tcattcagac gcctcctcgt agtaaaaaat
     9001 atcttcaatt tttacatcaa aatactgagc tatcttaaaa gccaaaatta aagagggatt
     9061 atatttacca ttttcaatag acccaattgt ttgtctcgat acctttaaaa ttctaccgag
     9121 ttcttcttgt cttagtcctc gctgttttct catagtttct aggtcatttt tcaaaataat
     9181 cacccccaaa aaggaaagtt aacttaacat tatattatga caatcatttt aaaatgtaaa
     9241 gctaactttc cgaagtatgg taaaggtgta ctactttagt atctttactt tcttatctag
     9301 aacttcctga aaactatcgc actcaaaaaa gccattctct ctccaataaa tatgctccac
     9361 atggtcttct ggataattct catatatcca cttgaaagaa aggaatgcag cttctaaagc
     9421 atcattactc tcagttacta tttcttcttt aaggtgcttg agaattgcat gtgtattatt
     9481 tgcaatatcc tcctccttaa tttctgcccc tgagattgca cttactcgtc ctattgtaat
     9541 aatacccata taggttgaaa ctttctctaa gtaatctaat acatggttta aaccatttcc
     9601 accagaagca acaacaagcc ctggctttcc agctaaccga aacaaatgtc cccaatagga
     9661 aagacgatca ataaatgcct tcatatctcc tgacacgtta tgtgaatata caggacttgc
     9721 taaaatcaca aaatcagatt caagtaattc ccgctttatt tcttccatcc gatcattatg
     9781 aagttgatct tgaggacatt tcccttttgt aaagcatgat ttgcaccctg ttgaatgaaa
     9841 gatatttgtt tcatatgctt tataaatagt aaatttgatg gattcatctt gtaaggagat
     9901 attttcaatc aatctattca gatatgtgta taatattgaa ttatcatttc gagaaccaat
     9961 ataaacgaaa acctttttca tcttttcacc tcttaattaa ctaattgaaa ctcaacacag
    10021 aaggaacact ttctggattt gctattctta gtaattgata accaattcca gctattccag
    10081 taaacattcc aacagatctg aagcctggaa tagatcgatc tttatagctt cctctttctt
    10141 ttgattcttg tattactttt agggctaaac ttttagctat tgtctcatac gacttatcat
    10201 tctttatttg agaagcatgt aaaaataatt cagtagtccc catattaccg tggcataagc
    10261 aatcatctga tttataggga ctattaagag ttatatctaa tgctttctca atttctgtgt
    10321 ttgttctttc atcatttata aactgtgata ttagtaatct acttatccct ataccctcag
    10381 tcccatggca ccattgatgt ctacatatat tgtcatcggt actaatatct aaccaaccat
    10441 tgcaaccttc tgagaataga gattgatcaa actctaatag actttttcct ttctctaaga
    10501 atttctttga tttagttatt gtacctaacc taatcaatac atatgctacg gagctactac
    10561 cgtgcgcaaa tccgcctaat aatctatctg tactatccag ctgtcgtatc aatttatttg
    10621 ccaatttaat acataatgct aaaatctcag gatccttact ctcttcaaag atattgatta
    10681 cacaatgtaa gaaaccagta gttcccgaca tccagtcata accaataaaa ttatcaagat
    10741 tatcctctcc taacttcaat agttttaata aacgatcttt ccatttagaa tcacctttaa
    10801 tttgatagga aattttagct aatgggtata acaaggaaag ttgccctgta aatatagagt
    10861 agtcatctaa aacaaccatt ctttcttcag ctgaatttaa taatttccta tagatatctt
    10921 catatctatc ttcctttgtt atttgatgca aataataata aaaatgaaac aacccagaaa
    10981 gtccatcata aaagtcagat gtaattggag ttatgtcaaa tgaatccttt actacattta
    11041 tacctaacca agacactgtt tctccatttt ctgaataaat tgctttactt aaaatgtggt
    11101 cacctattgc ttttgcttcg tttacaaaaa tatcattatc aatgttgttc acatctactt
    11161 tttttatcga gtcttttatg gtgcacgatt tccctttctt ttcttcattt tgaatcaatt
    11221 tttcatacat acccgtctta acaacaataa ccgaaacctg cttctccata tcttcagcat
    11281 tcattttatt aattttatca agcaacagag aatatccagt acttttataa acatctctat
    11341 atatctttcc agtactatct attaagtctt tggagttcgt atagttaaaa aaaattggga
    11401 tatcatcatt cagaagatct tcatattcac ttttaataat tgatttagct tgataaggaa
    11461 ctgaccatat attttcaata acttgttctc tatctaaagc atgccttaaa taatctgggt
    11521 gatacgtatt attaatcata ttaaaatatt gtgttgtacc tcttgggata attcttactt
    11581 ttaatttatt aaaattagag agtacctttg tttcttttaa taaagaatcc ctattagcta
    11641 aaataactga ataaacaacc ttaaaacctt ttataatttc ttctatataa tttgtataat
    11701 caataggttg tccatttaac tcaggtagat tattggctcc cttagtagtc cattcaatta
    11761 aaccgtattt catttcatct gaatttatat tgattggacc tggaacttta tatggcagct
    11821 tttgagactt tccatttaac ccactcatat caatacctga atcatttaaa agattctctt
    11881 ttatttcaat gggtaacagc attgtgctgc taaccaattc ttgagcttca taacttgcat
    11941 taacatacgc agaatcagac caattaaaca aaatactatt atgtaataaa gtctcaaaat
    12001 cgacaataat tggattagaa ccactggcga ttatattctc catatgcata tcggttccat
    12061 ttaaggaata cactattgcc aagagttgtc caaatcttat gtaaaaattt cgaacttctt
    12121 cctcactatc acaacccttt ttctccacaa tttcttcaaa cgagtaatct ttgtacccta
    12181 atattctgta agtagccatt tcgagcacat cttcatattg attaatccaa ttaagatagt
    12241 cctgataagc atttccaata tctgtattcc tcggtttata gaagagatgt ttagttgatt
    12301 caaattctat tctaaaaaca ttcctacctt gttgatgcga atctccttct ccaaatgtaa
    12361 tcgtcttaat aaaatcatta gatgataagt tgaatttaga atatatttct tccttatgta
    12421 gaagaaacct gtcaatgaac tctatagtat ttttgtaaaa aaacagggtc ttagttgcta
    12481 agattctact caaaacttgg tactcttcat agaaggcgat taaaatatct aagtcataaa
    12541 atctctcatt gaatgaatga aatctttctt cggagctagt tccagttagt tcatttctta
    12601 atctagatac attaagttcg agaactagac ttttatgtgc aatttggcca agactatcaa
    12661 taaaccctgc catcaatgta tctaagtcaa aataacgaaa tacatcttta ctttcaatga
    12721 atttggagag tttatttcct aaaaacagtg tgaaagggcg gagtatataa ctaaatccaa
    12781 ggtttgaatc atatttagta ttattaacct caactaattc aattgcctct ttgtataact
    12841 gaaaccattc agcttttaat agatattcac atatttctcc tgtcttatct tcctcatttc
    12901 tcattaggca gttcgagaat atttcttctt catagttcca ctcacttaac attaatgaaa
    12961 aagattcatc agacactatg ttcttcctat tcctccaggc tttatattct ttctcagata
    13021 aagacgtaga agagttttga tataatggat atttttcttt gatccataat gaatttagat
    13081 aattaatagg taatatttct ctttttacca gcattctacc acactcctca taagtagtat
    13141 tgatagaaaa ataagctaaa actaattatt attagtctag cttatttttc taagtatctt
    13201 ggattactta caaaaaacag cagttactaa ataggaacct acaaaacttg ctagtgctga
    13261 aatgactgta gcagctggag taccttgtgg ttgaatttct ccatttcccc cacaaacact
    13321 agatatttct ttcaaatcta attcttgaaa ccctagtcct gatggatgtg aaatacttgt
    13381 accatctctc aactctggat tcttccatct cataataatt tcttcggaac tcatatattt
    13441 gtctcatcct ttcatccata aatctttcca ataattatat ctagattgtt tttagaatgt
    13501 gtcaatgtag ctacgtcgag gttacacatt agaagtgtcg taggagtgtc gtaggagtgg
    13561 catagaaaag taaataaaat aatagattat attacataaa ctatgaagtt gatgagtcta
    13621 tgtaattatc ctaaacagcc tttattaaaa gtaacaatac cacttatagc agaagcagtt
    13681 gcactaatag ttgctggcac acagtatttt acagaaactg gtatagtcac tacacaaact
    13741 ggggtagtaa tagcattagg agtgtactct gaagctccat taactccgat catttcatcc
    13801 agagaaagct cttgaaaccc cttgccacat ggatgttcat tagataattc catttctttt
    13861 ctcattgccg ggtttttcca catcataatt ttttgttcgt ttgtcatttt acatctctcc
    13921 ttttttattt ttccttacaa aaccataata ggataatgtt ggtaataaat caatatattt
    13981 ttgttaagtg tatttaacat tttatctatt caaaatatta ttgagttatt tatttttagt
    14041 agtaaattct aaataatact tgctaagtat tcatctaatt ctatatttgt aaatttcata
    14101 cttaggaatt aatcaattta catctaatag tttaaaataa aagataatag tgtatctttt
    14161 cgtttgaaaa gtctttccaa atcttttagc atgatcttaa aacaaaaaaa catgtaaatt
    14221 actttagtaa agcaatttac atggtttttt aataaaagcc gataagattt tagcgtctac
    14281 tattaattat aaattataat taccttatga tttacataag atatgatggg taagaagtta
    14341 ttaaaatttg ttaattttac aggtgctggt ttaattatat aaatttttca attctattat
    14401 caactcgagc atttacatat ataataaagg gacaatcatt atatttttct tcgaaggaat
    14461 atagcgaggt caggtaaaat tgcttattat ttaaagtcct tcttccacct atgccccttt
    14521 agttcaataa gaacaaggct ttgttatgtc agagaacgct tgagccatat ggacaaccgg
    14581 actactctta tagtttactc acacgtgaca aaaagaattg cgtgaagaag atataaaggc
    14641 taaagtagaa atattttggt gacatattat atgcttaata tatttgatta aacgcatgct
    14701 gaattccagc gtgcgtttta ttattactca gttataacgg atttactaac tgtaaagtcc
    14761 cataagaagt ttacctgaag taacagagaa gataatggat tacccagtag atatcaagag
    14821 aggcaattag gggagctaac agcacctata tgaatgaagg catgatctcc ttgtagcgat
    14881 tgataacaaa gaggccattt ctataaaaat tgtatttacc cagctttttt tattacagaa
    14941 ttattgataa tgacacaaag tcttcattac caaggggcta gcttctgtaa atgtgactct
    15001 ttatagtaaa gtcatgggac aaaatacaaa aaatcaatga cattttatgt taatttccac
    15061 atatgacatc atatgttcac atgaaaaaag ccgcgcagtg gcggctatca agaggggata
    15121 aaacttttat aagtgtattg gaggcatttt gtgtgcagat tatgtttgtg agggattaat
    15181 gttcgtggag ttgatacgtt tgttcacata attgatattg aagctccttc atgttagaca
    15241 attcttttat gaggatttgc agagtctgtt cgatttttct caaatctgac tcacttttgg
    15301 atacacggct atttacactg ccaacgattc ggattaaatc agcgactact tcccgctcgt
    15361 tcataaaata ggcactgcgt tcgtttccag actgccttca tgaaggttat tcacccgttt
    15421 acgatctaaa aagttaacac tttccactat aacttctgtt acatacgtac gtttaccttc
    15481 tggattctca taattacgtg tatgaattct tccaacaata ctgactacag aacctttttg
    15541 acaataggat gctgtatttt cagctgcccg attccaaatt gtgcagttta caaagtccgt
    15601 cccatactcg ccatctgcat tcttaaaatt cctcgtaacg gccaaagtaa tgtttgatac
    15661 agctttgcct tccggtgtat aacgcagatc aggatccttc gtcagccttc caacaagcgc
    15721 aacctgattt aacatactac cttcacctct cttttatata gcttacagag gtatcataaa
    15781 agagttatgg ttaaaagtaa aagaggcgat ttgggacttt agagggagat tttcactcaa
    15841 atttcctttt tgaatatata aatatggtgt ttgtaatcaa tatttataat ctgtgaatta
    15901 tttaacaaac tcttcgacaa acaatataaa tattttttct tttttttacc atgctataat
    15961 gaacatataa taatttaaaa ttggaggtaa gttgatgaaa acctttaagt tagtttcctt
    16021 gcagttactt ccagacaatc agcatccaac cgaattacat atcctagacg gattaattat
    16081 taataaagaa aatgaggcaa acacttggct tattgaggca gtcgttgatt atgaacattt
    16141 caatcttttc aaggaaatca ctgctgatac tgacaagctt accgttagct gtatcatcac
    16201 aaagaaggat aatatccctg cctacttcga tgcaactatc gctgatgtcc gcaagatgga
    16261 tcaattcgcc agcatcctgt ttcgggcaaa gattcgcaat cgcagaagag aagccgttga
    16321 attcctattg gatacactag tagatgaagg atataatggt gaggatttaa aaaacgcctt
    16381 taaagaaggc ctgggtaata aataacagct ggcgagatta cctcgccagc ttaaacttgt
    16441 tacttatttt tatctttacc attgttattg ttgttatcaa ggatatcgtc tgcgcctcga
    16501 tctgcatcgt tcctgattct atccccatct tctcttacat ctgtatctaa ctcagaatct
    16561 tgaccattat cattagtatc attcatacca ttattatcat cgttaccgtt gataccattg
    16621 ccattattgt tattgttgcc attcataccg ttattatctt ttgtgctttc gttcgtatct
    16681 atcccattat tatcgttcgt tccgttattt tgctcttggt tgttgttacg ttctggaggc
    16741 gggttattgt catcgttatt attacacccc accattaata cagatgccaa cgcaaccccc
    16801 ataatcgctt tataaaactt ctgcattcgg catgctcctt tcatacattt atgacctgat
    16861 caggtctgtt tttagattac ccagaagagg acagattatg atgggcaaaa aaaagcaggc
    16921 ccaaacattt gggccttcaa atagggagaa gtgatatggt tatccacgtg ccagtgcata
    16981 tacactagct tatattcctt taataacaca aacaggtaaa ttctaaacgt atttgcgaaa
    17041 attgccttca ccgtaaaata aacttctctt atttcagctt atgcttaccc taatttttat
    17101 tgattggatg gttcatacta atacagccag agttcctgaa agcattttgc ataaaggcct
    17161 caaggtaaaa ggcatacatc ataagcgagg aaaactttat ggatataaaa aaagtcgaac
    17221 agatgaaaga tcaatctatg aagagactcc atttaaagga cctgaaagac caggtaattg
    17281 ttattactgg tgcttccagc gggattgggc ttgttacggc acggatggca gctgaaaaag
    17341 gagctaaggt tgtcgtggcg gcccggaata aagatgccct ccaggaatta gtctacgaat
    17401 tgaaaagcaa ggggcatgaa gcagtctggg ttgctgcaga tgttggagtt gaagaggatg
    17461 tccttaaaat tgctgaaaca gccatcttga attatggcgg ctttgataca tgggtaaaca
    17521 atgctggtgt ttcgatttat ggaacaacaa ccgaagtcag cataaaagat atgcgacgta
    17581 tgtttgatac tgttttttgg ggtgtcgttt acggatccag aatcgcggtc gagcattata
    17641 aaacacgtgg tggccctggt gccattatta atatcggcag tttctttggt gataggggaa
    17701 ccgttatcca gtccacctac tcctctgcca aatttgcttt gcatggctgg acggaaaacc
    17761 tgcgaatgga gctcgagaaa gaaaacgctc caatttctgt gacgctcatt caccccggaa
    17821 gaatcgatac accatacaat gagcacgctc gcagttatct ggaaaagcag ccgactcata
    17881 taggaatgat ctatgcacct gaaacagtag ccgaggccat cctctttgcc gcagagcatc
    17941 caaaacgtga tatgtatgtt ggatctcagg ctaaattcct ggctatgcta ggcaggtttg
    18001 ccccaaggtt taccgataaa tttgtggaaa agactatgta ccatacacag catgatgacc
    18061 gtccatccaa cccaccggag gatagcgccc tgtacaaagc tggatacgga ttgcatgaac
    18121 gcggcaccaa taaaggctgg atccgtgaaa caagctatta tgtgaaagca tccaaacacc
    18181 cagtcctaac ttccgtactg gtagccggga ttggcgcttg cctattagca accttcatgc
    18241 aaaataagta agcaatattg aaaaagcaga aggcctttgt tgaccttctg ctttctgatt
    18301 ctctttatga aaagaaaaaa agaagatgtt aggacttctc atcgcctaaa gcaaacgtta
    18361 tttcggcttc acaagccaac tcgccattca cagtcgccct gccaattcct tttccaatcg
    18421 gaccgcgcac tcttgtcaat tctacttcca aacgcagttg gtcaccagga cgcacctgtc
    18481 tcttaaagcg gcatttatca ataccggcaa aaaatgcaag cctcccctta ttttcctctt
    18541 taatcagaac agccaccgct cccacttgag ccagcgcctc cacaatcagc acccccggca
    18601 taactggata atccggaaaa tgaccattaa aaaactcctc attcgccgtc acattcttaa
    18661 ccccaactgc ccgcttcccc tcatcaacct ccaaaatctg atcaaccaac aaaaacggat
    18721 accgatgcgg aataatctcc ttaatttgct gaacatctaa catataattt ccccctttat
    18781 ttataaagct gagacggctt gctcagaagc gaggagcata agacaggaca tcggaaggag
    18841 gtgttcttcc tcctgccgag gtcatgctta tgtcctgagc ttctagccgt cgaagctgga
    18901 ttacactata aagctgaagg gccttattca atgaacgaag actaaatgcg ctacgtcctg
    18961 tggcaacgtc ttcatgacct acatcctgta ggctcgcgag gagcataaga caggacatcg
    19021 gaaggaggtg ttcttcctcc tgccgaggtc atgcttatgt cctgagcttc tagccgtcga
    19081 agctggatta cactataaag ctgaagggcc ttattcaatg aacgaagact aaatgcgcca
    19141 cgtcctttgg ccacgtcttc atgacctaca tcctgtaggc ccgcgacaag cataagacga
    19201 atactcggag ggaaggttct ctcccgtaga gtatttgctt atgactcgag ctcctaggag
    19261 tcgaagctgg attaaatcaa aaagctgaag gccttaaaca aggaacgaag actaaatgcg
    19321 ccacgtcctg tgacaacgtc ttcatgacct acatcctgta gcccgcgaca aatgtaatga
    19381 gacgcgaaag tggtaagacc acttttcatc aaacttctcc tacctaataa aaaacaggaa
    19441 gggatatatc ttgccttcct gcccgtatta tttgtcttta ttctccgtcg tgtccttatt
    19501 gaccaaatca acgatatgag tccatgtaga tttcttaaaa acatccattg cttttccatc
    19561 acccataacg gaatagccaa ccatggctcc accaacaagg gccatcatcg tcaacacaag
    19621 gacaattata atacgagccc aaagtggcac taaccggatt ttgatttttt gatcattacc
    19681 cagttttttt ctatctattc gactgtttgg ttcagactca gtctgctcac ttttattatt
    19741 aaccaacgct tgcattcttt tactccttta acgaataccg ttgaccaacc ccatcatttg
    19801 atcggccata ctaaccgtcc gtgattgaaa ttgatataac ctctgagttt gcatcatttc
    19861 tgtcatctca gtactaatat cgacattaga ttgttccaag tttccttgaa ccatagaaat
    19921 ttcatctcta aaagcaccgg ttagttgggt atatatgtcg ttttctgata catccaattg
    19981 tgccatattt ttcggaagag tgaaagtatt attatttatc atttccataa attgaggctt
    20041 cttgacggag ataatcccca gattaaatga ttgcatccca ttttcagtag cgacatttag
    20101 ctggccttta tctgtaaatg ttatgtcact agggttacca tttatcctaa tttcctgatt
    20161 attttcatcc aatactgcac tgccatttga tgttactagt tgcacatgat tagatccatc
    20221 agaagctgga ctaagataaa aagccccatc ccttgtgtaa ccaagctgac tgctagtgcc
    20281 atctgccgtg cgaatggcaa aaaataaatt ctcattagta agagcgacat ccaagtcacg
    20341 ttccgttttt tgcagattac cctgtgccaa attaagctga gactgaatca tttttgcgcc
    20401 aacacccact cgaataccat ttggcgtcaa tcggcctttt tccttctcag ttcgctcctg
    20461 attattgaat tcctgagcaa gcatgtctga gaaataggta tcttttcttt taaaaccggt
    20521 cgtcgaagta tttgagatat tattcgaaac tgtttccaac ttcttttgca gctgccccat
    20581 tgtatttgat gaggttatca tcattcgatt catccttatt taccctcctc ttcattcagc
    20641 tctttatcga ttacagctta cctatttcat tgacggtttt ttgcatgctt tgatcatagg
    20701 cttgtacaat cttttgattg gcttcaaatg tacgataggc agccatcata tcagtcattg
    20761 ttttggatga atccacattg gactgttcaa ttgaaccttg ttgaacagca aattgaacat
    20821 tatttaatgt ataggcagaa ggcagctctc cttcattgat ccggtataat ccatcgcctt
    20881 ccttgatgag ctgtgccgtt ggagtagcgc taaagcttat tccaattcgt cctctattca
    20941 atgttccctc agatatctca ccctgagaac taatcgcaaa attttcggag tttaaaagga
    21001 tacgttccct attctcatct aggacataat aaccgttagc agttgttaaa tagcctgagc
    21061 catctaatgt aaaattcccg tttcgtgtat atctcaagcc atcaggagtc tcaactgtaa
    21121 acagggccgt acccggttga ttcctttcag gatcaatagg catagcttga tctacaatag
    21181 ccatgtccgt agtattgtcg gttgttttaa catcaccctg tgaaaaagac gggatagtct
    21241 cttgtacata aacacccgtg ttcaatgcac ccacatattt tgaatgattg atggatactg
    21301 attcctcaac gggaagattc actttttcat aactgctaag cagcatttct ggaaatgagc
    21361 gtacactcgc ttgatcctct ttatatccga ccgtattggc attcgctaaa ttatttgcaa
    21421 gcagctccgt tttgcgttgc tgagccagca taccggatgc cgctgtatag aatcctttaa
    21481 acatttctcc acccccaaat aggcctaaca aacacccata ttaccattat atagggaata
    21541 attttataag atacggactt ttttcctaaa aaccgatttc tctcgacata gggggagtat
    21601 atgtggactt tgtagtgtta actggagttg tgtggaagga gagatgttgt agaggtgttg
    21661 cataggtcgg gtataggcgc tccatagccg gggcataggc ggagcatagc tgctttcctc
    21721 tacccttcac ctacctttga ccgacctata cccgggtata ggtgcctcat agccagggca
    21781 taggtggacc atacctgctt tcctctacct ttcacctacc tttgaccgac ctatacccgg
    21841 gtataggtgc ctcatagcca gggcataggt ggaccatacc tgctttcctc tacctttcac
    21901 ctacctttga ccgacctata cccgggtata ggtgcctcat agccagggca taggtggacc
    21961 atacctgctt tcctctgcct ttcacctacc tttgaccgac ctttacccgg gtataggtac
    22021 ctcatagcca gggcataggt ggaccatacc tgctttcctc tgcctttcac ctacctttga
    22081 ccggcctata cccgggtata ggtgcctcat agccagggca taggcggacc atacctgctt
    22141 cactacaacc tctcacctac ctttcacctg cctttcacct gcctttcacc tgcctttaca
    22201 caggcacagg tcgcagcata gatgaatcat tcccacgcac ggcattgccc tccacaagag
    22261 gacatccctt acccatacaa aaaaaccagt tcatcaactg aactggtttt atattgcctg
    22321 gtgattatac taatttacgg cgagtgattc gatcaatatt atcaagcatc atacctgttc
    22381 ctattgctac gcaatccatt ggattttctg cgattaatac aggtaccttt agttcttcag
    22441 ccaataacat gtccatgccg tgaagcagag ctccgccgcc tgttagaatt actccgcgat
    22501 caataatatc agcggatagt tctggaggtg tttgctccaa cacagatttt gctgcatgaa
    22561 caatgacatg aatggactca cgtaatgcct cttcgatttc ttctgaacca actgtgatgg
    22621 tttttggtag ccctgtcacc atatcacgtc cgcgaatatc aatagtttca ttacgggaac
    22681 ctttaaaaac ggtcgcaact ttcactttta tatcttcagc tgtacgctct ccgattaaaa
    22741 gcttgtatgt acgtttgatg taatttagaa tctcggcatc aaatttgtca ccagccattt
    22801 ttatggatgc tgatgtaacg atatccccca ttgataatac ggcaatgtca gttgtgcctc
    22861 cgccgatatc gatgaccatg ttaccgcttg gttggaagat gtccatacct gcgccgattg
    22921 ccgctacctt tggctcttcc tcaaggtaaa tctttttgcc gccacttttc tctgctgctt
    22981 cacgaatcgc tttttgttca acgcttgtaa tattagttgg acagcaaatc aagatacgtg
    23041 gttttgataa gaatcctttt acgtccaatt tgttaatgaa gtattttaac atggattccg
    23101 ttacatcaaa gtca
//
