GCF_008923765.1 - 18 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NZ_WBPC01000041.1 (Bacillus cereus)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1.1	NI-siderophore	94,273	125,980	High	petrobactin	other:other
Region 1.2	NRPS,transAT-PKS	168,527	231,517	Low	bacillothiazol A/bacillothiazol B/bacillothiazol C/bacillothiazol D/bacillothiazol E/bacillothiazol F/bacillothiazol G/bacillothiazol H/bacillothiazol I/bacillothiazol J/bacillothiazol K/bacillothiazol L/bacillothiazol M/bacillothiazol N	NRPS:Type I

NZ_WBPC01000009.1 (Bacillus cereus)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 2.1	NRPS,RRE-containing	87,566	132,440

NZ_WBPC01000014.1 (Bacillus cereus)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 7.1	terpene	49,249	71,102	Low	molybdenum cofactor	other:other

NZ_WBPC01000016.1 (Bacillus cereus)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 9.1	terpene-precursor	185,398	199,775	Medium	cerecidin/cerecidin A1/cerecidin A2/cerecidin A3/cerecidin A4/cerecidin A5/cerecidin A6/cerecidin A7	ribosomal:RiPP:Lanthipeptide

NZ_WBPC01000017.1 (Bacillus cereus)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 10.1	azole-containing-RiPP	171,298	194,804
Region 10.2	lassopeptide	388,015	410,513

NZ_WBPC01000018.1 (Bacillus cereus)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 11.1	betalactone	1	19,957	Low	fengycin	NRPS:Type I
Region 11.2	RiPP-like	71,676	81,984
Region 11.3	RiPP-like	172,067	182,312
Region 11.4	NRPS	203,101	250,116

NZ_WBPC01000023.1 (Bacillus cereus)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 17.1	NRPS-like	1	40,357

NZ_WBPC01000024.1 (Bacillus cereus)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 19.1	CDPS	32,642	53,361	Medium	pulcherriminic acid	other:other

NZ_WBPC01000027.1 (Bacillus cereus)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 22.1	lanthipeptide-class-ii	379,712	393,061	Low	cerecidin/cerecidin A1/cerecidin A2/cerecidin A3/cerecidin A4/cerecidin A5/cerecidin A6/cerecidin A7	ribosomal:RiPP:Lanthipeptide

NZ_WBPC01000003.1 (Bacillus cereus)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 25.1	NRP-metallophore,NRPS	201,470	253,218	High	bacillibactin	NRPS:Type I

NZ_WBPC01000005.1 (Bacillus cereus)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 31.1	NRPS	44,017	109,931

NZ_WBPC01000036.1 (Bacillus cereus)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 34.1	lanthipeptide-class-ii	24,753	43,971	High	thusin	ribosomal:RiPP

NZ_WBPC01000040.1 (Bacillus cereus)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 40.1	terpene-precursor	693,899	714,789

No secondary metabolite regions were found in these records:: NZ_WBPC01000010.1 (Bacillus cereus); NZ_WBPC01000011.1 (Bacillus cereus); NZ_WBPC01000012.1 (Bacillus cereus); NZ_WBPC01000013.1 (Bacillus cereus); NZ_WBPC01000015.1 (Bacillus cereus); NZ_WBPC01000001.1 (Bacillus cereus); NZ_WBPC01000019.1 (Bacillus cereus); NZ_WBPC01000020.1 (Bacillus cereus); NZ_WBPC01000021.1 (Bacillus cereus); NZ_WBPC01000022.1 (Bacillus cereus); NZ_WBPC01000002.1 (Bacillus cereus); NZ_WBPC01000025.1 (Bacillus cereus); NZ_WBPC01000026.1 (Bacillus cereus); NZ_WBPC01000028.1 (Bacillus cereus); NZ_WBPC01000029.1 (Bacillus cereus); NZ_WBPC01000030.1 (Bacillus cereus); NZ_WBPC01000031.1 (Bacillus cereus); NZ_WBPC01000032.1 (Bacillus cereus); NZ_WBPC01000033.1 (Bacillus cereus); NZ_WBPC01000004.1 (Bacillus cereus); NZ_WBPC01000034.1 (Bacillus cereus); NZ_WBPC01000035.1 (Bacillus cereus); NZ_WBPC01000006.1 (Bacillus cereus); NZ_WBPC01000037.1 (Bacillus cereus); NZ_WBPC01000038.1 (Bacillus cereus); NZ_WBPC01000039.1 (Bacillus cereus); NZ_WBPC01000007.1 (Bacillus cereus); NZ_WBPC01000008.1 (Bacillus cereus)

Compact view

NZ_WBPC01000041.1 - Region 1 - NI-siderophore

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Location: 94,273 - 125,980 nt. (total: 31,708 nt) Show pHMM detection rules used

NI-siderophore: IucA_IucC

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

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Gene overview

Tailoring

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SubClusterBlast

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Gene/CDS overview

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Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: aminotransferase

F8159_RS28455: aminotransferase

smcogs: SMCOG1019: aminotransferase

Hydrolases: deacetylase

F8159_RS28520: polysaccharide deacetylase

smcogs: SMCOG1235: polysaccharide deacetylase

Ligases: ligase synthase

F8159_RS28490: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

F8159_RS28545: cysteine synthase

smcogs: SMCOG1081: cysteine synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000942.4	0.88	other (other)	petrobactin	Bacillus anthracis str. Ames
BGC0002469.2	0.54	other (other)	woodybactin A, woodybactin B, woodybactin C, woodybactin D	Shewanella woodyi ATCC 51908
BGC0001572.3	0.51	other (other)	desferrioxamine E	Pantoea agglomerans
BGC0000295.5	0.51	NRPS	acinetoferrin	Acinetobacter haemolyticus
BGC0002620.2	0.50	other (other)	fulvivirgamide A2, fulvivirgamide B2, fulvivirgamide B3, fulvivirgamide B4	Fulvivirga marina
BGC0002692.2	0.50	other (other)	speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B	Kribbella speibonae
BGC0002305.2	0.50	other (other)	legonoxamine A, desferrioxamine B, legonoxamine B	Streptomyces sp.
BGC0001531.5	0.50	other (other)	bisucaberin B	Tenacibaculum mesophilum
BGC0001713.5	0.48	other (other)	ochrobactin	Ochrobactrum anthropi
BGC0002633.2	0.47	other (other)	schizokinen	Leptolyngbya sp. PCC 7376

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000942.4	0.88	other (other)	petrobactin	Bacillus anthracis str. Ames
BGC0002469.2	0.54	other (other)	woodybactin A, woodybactin B, woodybactin C, woodybactin D	Shewanella woodyi ATCC 51908
BGC0001572.3	0.51	other (other)	desferrioxamine E	Pantoea agglomerans
BGC0000295.5	0.51	NRPS	acinetoferrin	Acinetobacter haemolyticus
BGC0002620.2	0.50	other (other)	fulvivirgamide A2, fulvivirgamide B2, fulvivirgamide B3, fulvivirgamide B4	Fulvivirga marina
BGC0002692.2	0.50	other (other)	speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B	Kribbella speibonae
BGC0002305.2	0.50	other (other)	legonoxamine A, desferrioxamine B, legonoxamine B	Streptomyces sp.
BGC0001531.5	0.50	other (other)	bisucaberin B	Tenacibaculum mesophilum
BGC0001713.5	0.48	other (other)	ochrobactin	Ochrobactrum anthropi
BGC0002633.2	0.47	other (other)	schizokinen	Leptolyngbya sp. PCC 7376

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 15.13 out of 18.16

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.38 out of 29.38

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.37 out of 27.78

Confidence: medium

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.99 out of 30.25

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.03 out of 20.97

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.55 out of 19.26

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.55 out of 19.26

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 23.93 out of 28.19

Confidence: medium

Additional weak hits (4):

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 25.60 out of 36.54

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.66 out of 32.74

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.50 out of 32.74

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 20.88 out of 26.12

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
CRP	Cyclic AMP receptor protein
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
ColR	Phenol-responsive regulator
FuR variant 1	Ferric Uptake Regulator
ZuR variant 1	Zinc-responsive repressor

NZ_WBPC01000041.1 - Region 2 - NRPS,transAT-PKS

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Location: 168,527 - 231,517 nt. (total: 62,991 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: PPTase acylase

F8159_RS28870: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1012: 4'-phosphopantetheinyl transferase

F8159_RS28890: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Hydrolases: esterase peptidase

F8159_RS28925: thioesterase

smcogs: SMCOG1004: thioesterase

F8159_RS28950: methionine aminopeptidase

smcogs: SMCOG1172: methionine aminopeptidase

Ligases: ligase synthase

F8159_RS28880: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

F8159_RS28885: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

F8159_RS28900: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

F8159_RS28910: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

F8159_RS28920: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001249.5	0.85	NRPS	dimethylcoprogen	Alternaria alternata
BGC0002164.2	0.72	NRPS	peramine	Epichloe festucae
BGC0001132.4	0.69	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001261.3	0.68	NRPS	AM-toxin	Alternaria alternata
BGC0001128.4	0.67	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5	0.66	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0002286.3	0.64	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001240.4	0.64	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0001758.4	0.64	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001833.4	0.63	NRPS	icosalide A, icosalide B	Burkholderia gladioli

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001249.5	0.74	NRPS	dimethylcoprogen	Alternaria alternata
BGC0002164.2	0.69	NRPS	peramine	Epichloe festucae
BGC0001132.4	0.67	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001261.3	0.67	NRPS	AM-toxin	Alternaria alternata
BGC0001128.4	0.67	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5	0.66	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0002286.3	0.65	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001240.4	0.65	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0001758.4	0.65	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001833.4	0.65	NRPS	icosalide A, icosalide B	Burkholderia gladioli

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 25.99 out of 30.25

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 26.38 out of 27.78

Confidence: strong

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 19.86 out of 21.84

Confidence: medium

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 20.94 out of 25.31

Confidence: medium

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 20.67 out of 25.31

Confidence: medium

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.73 out of 29.25

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.52 out of 29.38

Confidence: medium

Additional weak hits (7):

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.13 out of 25.88

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 24.71 out of 32.74

Confidence: weak

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.99 out of 27.55

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.52 out of 29.38

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 25.97 out of 33.14

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 25.43 out of 33.14

Confidence: weak

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 16.76 out of 30.12

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 2, location 168526 - 231517:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (fatty_acid) + (Gly) + (mal - Gly)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

F8159_RS28880: Gly

Search NORINE for peptide: strict or relaxed

AMP-binding (659..945): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: N/A
Single AA prediction:: gly (Gly)

Stachelhaus prediction details:

Stachelhaus sequence:: FAMTFDIFILEYQLIVGGEYNAYGPTEATVWATY
Nearest Stachelhaus code(s):: Gly DILQIGMVWK (68% 8Å match)
Stachelhaus code match:: 90% (moderate)

F8159_RS28890: mal

PKS_AT (6..292): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 79.2%; inactive: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 89.6
inactive: 39.0
Methoxymalonyl-CoA: 34.8
Methylmalonyl-CoA: 22.2
Propionyl-CoA: 17.2
Ethylmalonyl-CoA: 8.6
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Isobutyryl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

F8159_RS28910: Gly

Search NORINE for peptide: strict or relaxed

AMP-binding (270..665): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: N/A
Single AA prediction:: gly (Gly)

Stachelhaus prediction details:

Stachelhaus sequence:: FGMTFDIFFVEFQMLVGGEFNLYGPTETTIWSTI
Nearest Stachelhaus code(s):: Gly DILQLGLIWK (76% 8Å match)
Stachelhaus code match:: 90% (moderate)

F8159_RS28920: fatty_acid

CAL_domain (160..462): fatty_acid

minowa: fatty_acid

Prediction, score:

fatty_acid: 150.4
NH2: 35.7
shikimic_acid: 0.0
Acetyl-CoA: 0.0
AHBA: 0.0

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
CatR	H2O2-responsive repressor
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
ColR	Phenol-responsive regulator
FuR variant 1	Ferric Uptake Regulator
MexT	Global virulence regulator
SypG	Regulator of biofilm formation and host colonization

NZ_WBPC01000009.1 - Region 1 - NRPS,RRE-containing

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Location: 87,566 - 132,440 nt. (total: 44,875 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: reductase

F8159_RS05710: alkyl hydroperoxide reductase subunit

smcogs: SMCOG1176: alkyl hydroperoxide reductase subunit

Lyases: lyase

F8159_RS05665: argininosuccinate lyase/adenylosuccinate lyase

smcogs: SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

Ligases: ligase

F8159_RS05670: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002458.3	0.37	NRPS	alazopeptin	Streptacidiphilus griseoplanus
BGC0001135.5	0.31	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0002135.2	0.31	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0000307.4	0.30	NRPS	AbT1	Aureobasidium pullulans
BGC0000342.4	0.30	NRPS	enniatin	Fusarium equiseti
BGC0000357.5	0.29	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0001249.5	0.29	NRPS	dimethylcoprogen	Alternaria alternata
BGC0001641.4	0.29	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4	0.29	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.29	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001135.5	0.64	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0002135.2	0.64	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0000307.4	0.63	NRPS	AbT1	Aureobasidium pullulans
BGC0000342.4	0.63	NRPS	enniatin	Fusarium equiseti
BGC0000357.5	0.63	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0001249.5	0.63	NRPS	dimethylcoprogen	Alternaria alternata
BGC0001641.4	0.63	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4	0.63	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.62	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001132.4	0.62	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 20.94 out of 25.31

Confidence: medium

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 20.67 out of 25.31

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.50 out of 27.78

Confidence: medium

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.85 out of 30.25

Confidence: medium

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 20.67 out of 25.31

Confidence: medium

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.54 out of 18.46

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 15.08 out of 18.16

Confidence: strong

Additional weak hits (4):

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.40 out of 20.01

Confidence: weak

RicR

Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 22.72 out of 32.93

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 26.72 out of 36.54

Confidence: weak

CsoR

Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 20.19 out of 32.38

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

RREFinder

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 87565 - 132440:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Leu)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

F8159_RS05670: Leu

Search NORINE for peptide: strict or relaxed

AMP-binding (638..1028): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: FSSAFDASVFETLLISAGSINAYGPTETTVYTVA
Nearest Stachelhaus code(s):: Leu DAFLIGAVMK (56% 8Å match)
Stachelhaus code match:: 80% (moderate)

Link to PARAS substrate predictor

RRE predictions

: RRE type: Pantocin_Microcin_RRE; Location: 0 - 95; Score: 94.4

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
CatR	H2O2-responsive repressor
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
ColR	Phenol-responsive regulator
RpoN	Regulator of nitrogen assimilation and virulence

NZ_WBPC01000014.1 - Region 1 - terpene

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Location: 49,249 - 71,102 nt. (total: 21,854 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

F8159_RS07620: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

F8159_RS07625: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Lyases: lyase

F8159_RS07595: argininosuccinate lyase/adenylosuccinate lyase

smcogs: SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000917.3	0.53	other (other)	molybdenum cofactor	Rhodobacter capsulatus
BGC0000888.5	0.49	other (other)	bacilysin	Bacillus sp. CS93
BGC0001928.2	0.46	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0000916.5	0.46	other (other)	molybdenum cofactor	Staphylococcus carnosus
BGC0000812.3	0.45	other (other)	huperzine A	Shiraia sp. slf14
BGC0000231.5	0.42	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0001605.3	0.42	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0001197.5	0.42	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0000234.5	0.41	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0002138.2	0.40	PKS	fuelimycin A, fuelimicin B, fuelimicin C	Streptomyces albireticuli NRRL B-1670

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000917.3	0.53	other (other)	molybdenum cofactor	Rhodobacter capsulatus
BGC0000888.5	0.49	other (other)	bacilysin	Bacillus sp. CS93
BGC0001928.2	0.46	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0000916.5	0.46	other (other)	molybdenum cofactor	Staphylococcus carnosus
BGC0000812.3	0.45	other (other)	huperzine A	Shiraia sp. slf14
BGC0000231.5	0.42	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0001605.3	0.42	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0001197.5	0.42	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0000234.5	0.41	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0002138.2	0.40	PKS	fuelimycin A, fuelimicin B, fuelimicin C	Streptomyces albireticuli NRRL B-1670

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
triterpene	hopanoid		C30	hopanoid skeleton	unknown
triterpene	polypodane		C30	polypodane skeleton	unknown

Genes with terpene domains:

F8159_RS07635: T2TS

Domain 1 (4 - 614): Type 2 terpene synthase

Subtype: Squalene substrate

Reactions:: squalene → hopanoid; squalene → polypodane

Transcription Factor Binding Sites

Binding sites found:

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 26.42 out of 30.22

Confidence: medium

Terpene

TFBS Finder

Glossary

No acronyms to display

TFBS definitions

Regulator	Description
ClgR	Caseinolytic protease gene regulator

NZ_WBPC01000016.1 - Region 1 - terpene-precursor

Download region GenBank file

Download region SVG

Location: 185,398 - 199,775 nt. (total: 14,378 nt) Show pHMM detection rules used

Region on contig edge.

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: protease

F8159_RS10425: alkaline serine protease, subtilase family

smcogs: SMCOG1075: alkaline serine protease, subtilase family

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000502.5	0.75	ribosomal	cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7	Bacillus cereus
BGC0000504.5	0.56	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0001555.4	0.52	ribosomal	colicin V	Escherichia coli chi7122
BGC0000590.5	0.51	ribosomal	microcin N	Escherichia coli
BGC0000588.5	0.49	ribosomal	microcin L	Escherichia coli
BGC0000623.3	0.49	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0002674.2	0.46	ribosomal	enterocin F4-9	Enterococcus faecalis
BGC0000500.5	0.46	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0001407.5	0.46	ribosomal	bicereucin	Bacillus cereus SJ1
BGC0000554.4	0.45	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000502.5	0.75	ribosomal	cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7	Bacillus cereus
BGC0000504.5	0.56	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0001555.4	0.52	ribosomal	colicin V	Escherichia coli chi7122
BGC0000590.5	0.51	ribosomal	microcin N	Escherichia coli
BGC0000588.5	0.49	ribosomal	microcin L	Escherichia coli
BGC0000623.3	0.49	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0002674.2	0.46	ribosomal	enterocin F4-9	Enterococcus faecalis
BGC0000500.5	0.46	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0001407.5	0.46	ribosomal	bicereucin	Bacillus cereus SJ1
BGC0000554.4	0.45	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor	FPP	C15	acyclic	PP
diterpene precursor	GGPP	C20	acyclic	PP
sesterterpene precursor	GFPP	C25	acyclic	PP
triterpene precursor	HPP	C30	acyclic	PP

Genes with terpene domains:

F8159_RS10440: PT_FPPS_like

Domain 1 (59 - 305): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

Transcription Factor Binding Sites

Binding sites found:

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 20.05 out of 23.43

Confidence: medium

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
BldD	Development and antibiotic global regulator

NZ_WBPC01000017.1 - Region 1 - azole-containing-RiPP

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Location: 171,298 - 194,804 nt. (total: 23,507 nt) Show pHMM detection rules used

azole-containing-RiPP: ((YcaO or TIGR03604) and (((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or thiostrepton or TIGR03602)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Azole RiPPs

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

F8159_RS11445: pyridine nucleotide-disulfide oxidoreductase

smcogs: SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001174.4	0.44	ribosomal	corynazolicin	Corynebacterium urealyticum DSM 7111
BGC0002013.4	0.44	ribosomal	curacozole	Streptomyces curacoi
BGC0000607.5	0.43	ribosomal	micrococcin P1	Macrococcus caseolyticus
BGC0001535.3	0.43	other (other)	branched-chain fatty acids	Streptomyces filamentosus
BGC0001146.5	0.41	ribosomal	cyclothiazomycin C	Streptomyces sp. NRRL WC-3908
BGC0001173.5	0.41	ribosomal	plantazolicin	Bacillus pumilus ATCC 7061
BGC0000606.5	0.39	ribosomal	lactazole	Streptomyces lactacystinaeus
BGC0001145.5	0.38	ribosomal	cyclothiazomycin b1	Streptomyces mobaraensis NBRC 13819 = DSM 40847
BGC0001640.3	0.38	ribosomal	kocurin	Kocuria rosea
BGC0000605.5	0.38	ribosomal	GE37468	Streptomyces sp. ATCC 55365

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001174.4	0.44	ribosomal	corynazolicin	Corynebacterium urealyticum DSM 7111
BGC0002013.4	0.44	ribosomal	curacozole	Streptomyces curacoi
BGC0000607.5	0.43	ribosomal	micrococcin P1	Macrococcus caseolyticus
BGC0001535.3	0.43	other (other)	branched-chain fatty acids	Streptomyces filamentosus
BGC0001146.5	0.41	ribosomal	cyclothiazomycin C	Streptomyces sp. NRRL WC-3908
BGC0001173.5	0.41	ribosomal	plantazolicin	Bacillus pumilus ATCC 7061
BGC0000606.5	0.39	ribosomal	lactazole	Streptomyces lactacystinaeus
BGC0001145.5	0.38	ribosomal	cyclothiazomycin b1	Streptomyces mobaraensis NBRC 13819 = DSM 40847
BGC0001640.3	0.38	ribosomal	kocurin	Kocuria rosea
BGC0000605.5	0.38	ribosomal	GE37468	Streptomyces sp. ATCC 55365

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.64 out of 26.06

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 26.38 out of 27.78

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 25.47 out of 26.06

Confidence: strong

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 22.11 out of 27.55

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 23.24 out of 28.19

Confidence: medium

(Thi)azol(in)e containing peptide predictions

No core peptides found.

RREFinder

TFBS Finder

Azole RiPPs

RRE predictions

: RRE type: Heterocycloanthracin_C_RRE; Location: 0 - 100; Score: 184.8; RRE type: Thiopeptide_F_RRE; Location: 10 - 89; Score: 41.3

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
GnfM	Regulator of nitrogen-fixation genes
MogR	Repressor of flagellar motility genes
ZuR variant 1	Zinc-responsive repressor

Core peptide predictions

No core peptides found.

NZ_WBPC01000017.1 - Region 2 - lassopeptide

Download region GenBank file

Download region SVG

Location: 388,015 - 410,513 nt. (total: 22,499 nt) Show pHMM detection rules used

lassopeptide: (PF13471 and Asn_synthase or micJ25 or mcjC)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lasso peptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

F8159_RS12535: FAD dependent oxidoreductase

smcogs: SMCOG1103: FAD dependent oxidoreductase

Transferases: kinase

F8159_RS12540: glycerol kinase

smcogs: SMCOG1210: glycerol kinase

Hydrolases: hydrolase

F8159_RS12520: asparagine synthase (glutamine-hydrolyzing)

smcogs: SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000571.3	0.49	ribosomal	burhizin	Paraburkholderia rhizoxinica HKI 454
BGC0001639.3	0.46	ribosomal	klebsidin	Klebsiella pneumoniae
BGC0002306.2	0.43	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0000623.3	0.42	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0002116.3	0.42	ribosomal	darobactin A	Photorhabdus khanii HGB 1456
BGC0000513.3	0.41	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0000501.3	0.40	ribosomal	catenulipeptin	Catenulispora acidiphila DSM 44928
BGC0002260.3	0.40	terpene	trichobrasilenol, xylarenic acid B, brasilane A, brasilane F, brasilane E, brasilane D	Annulohypoxylon truncatum
BGC0000504.5	0.40	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000552.3	0.40	ribosomal	SmbA, SmbB	Streptococcus mutans

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000571.3	0.49	ribosomal	burhizin	Paraburkholderia rhizoxinica HKI 454
BGC0001639.3	0.46	ribosomal	klebsidin	Klebsiella pneumoniae
BGC0002306.2	0.43	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0000623.3	0.42	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0002116.3	0.42	ribosomal	darobactin A	Photorhabdus khanii HGB 1456
BGC0000513.3	0.41	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0000501.3	0.40	ribosomal	catenulipeptin	Catenulispora acidiphila DSM 44928
BGC0002260.3	0.40	terpene	trichobrasilenol, xylarenic acid B, brasilane A, brasilane F, brasilane E, brasilane D	Annulohypoxylon truncatum
BGC0000504.5	0.40	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000552.3	0.40	ribosomal	SmbA, SmbB	Streptococcus mutans

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lasso peptide predictions

Lassopeptide(s) for allorf_400993_401079

allorf_400993_401079

Leader:

MHKIKKDRTL

Full core:

MNFCLVQPYFYGGSRCGY

Putative macrolactam:

antiSMASH-DB 4.0 matches for allorf_400993_401079

100.0%

NZ_CP031749.1and 4 others:

NZ_WBOZ01000026.1 Lassopeptides: allorf_285439_285525_lassopeptideNZ_WBPC01000017.1 Lassopeptides: allorf_400993_401079_lassopeptideNZ_WBPE01000032.1 Lassopeptides: allorf_334891_334977_lassopeptideNZ_WBPK01000046.1 Lassopeptides: allorf_129900_129986_lassopeptide

Lassopeptides: allorf_1046398_1046484_lassopeptide

1

MNFCLVQPYFYGGSRCGY

18

MNFCLVQPYFYGGSRCGY

1

MNFCLVQPYFYGGSRCGY

18

27.8%

NZ_AP018194.1:

Lanthipeptides: allorf_0326048_0326137_lanthipeptide

1

MNFCLVQPYFYGGSR

15

+N + PYF+G +

4

LNCSKITPYFWGTGK

18

MIBiG 4.0 matches for allorf_400993_401079

21.1%

BGC0002322.3 (CEJ66604.1):

Lasso peptide: citrocin

6

VQPYFYGGS

14

+ YF GG

6

IIEYFIGGG

14

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57

Confidence: strong

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 23.16 out of 27.55

Confidence: medium

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 25.52 out of 28.14

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.23 out of 26.06

Confidence: medium

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 22.64 out of 25.88

Confidence: medium

Additional weak hits (5):

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 20.68 out of 26.12

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 18.71 out of 30.11

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.53 out of 30.25

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 23.78 out of 30.98

Confidence: weak

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.58 out of 19.52

Confidence: weak

Lasso peptides

RREFinder

TFBS Finder

Core peptide predictions

allorf_400993_401079 - Class III: Cleavage pHMM score: -16.30; RODEO score: 16; Monoisotopic mass: 2087.9 Da; Molecular weight: 2089.4 Da; Number of bridges: 1

RRE predictions

: RRE type: Stand_Alone_Lasso_RRE; Location: 3 - 85; Score: 49.3

TFBS definitions

Regulator	Description
GnfM	Regulator of nitrogen-fixation genes
MogR	Repressor of flagellar motility genes
PerR	Peroxide regulator
PsrA	Oleic acid responsive regulator
ToxT	Regulator of MSHA biosynthesis

NZ_WBPC01000018.1 - Region 1 - betalactone

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Location: 1 - 19,957 nt. (total: 19,957 nt) Show pHMM detection rules used

Region on contig edge.

betalactone: (HMGL-like and AMP-binding)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

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Gene overview

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Gene/CDS overview

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Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

F8159_RS12760: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

Transferases: acetyltransferase carboxylase transferase

F8159_RS12765: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

F8159_RS12785: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

F8159_RS12810: GCN5-related N-acetyltransferase

smcogs: SMCOG1111: GCN5-related N-acetyltransferase

Lyases: hydratase

F8159_RS12780: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

Ligases: ligase synthase

F8159_RS12775: 2-isopropylmalate synthase

smcogs: SMCOG1271: 2-isopropylmalate synthase

F8159_RS12790: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002284.3	0.53	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000706.3	0.46	saccharide	kanamycin	Streptomyces kanamyceticus
BGC0000131.5	0.45	PKS	pyrrolomycin	Streptomyces sp. UC 11065
BGC0000234.5	0.43	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001103.5	0.42	NRPS, PKS	mycosubtilin	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0001095.5	0.41	NRPS	fengycin	Bacillus velezensis FZB42
BGC0001464.3	0.40	other (other)	tetrabromopyrrole	Pseudoalteromonas sp. PS5
BGC0001463.4	0.40	other (other)	2,3,4,5-tetrabromopyrrole	Pseudoalteromonas piscicida
BGC0000259.3	0.39	PKS	prodigiosin	Serratia marcescens
BGC0002147.2	0.38	NRPS	bohemamine A, bohemamine B, bohemamine C	Streptomyces sp. CB02009

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002284.3	0.53	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000706.3	0.46	saccharide	kanamycin	Streptomyces kanamyceticus
BGC0000131.5	0.45	PKS	pyrrolomycin	Streptomyces sp. UC 11065
BGC0000234.5	0.43	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001103.5	0.42	NRPS, PKS	mycosubtilin	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0001095.5	0.41	NRPS	fengycin	Bacillus velezensis FZB42
BGC0001464.3	0.40	other (other)	tetrabromopyrrole	Pseudoalteromonas sp. PS5
BGC0001463.4	0.40	other (other)	2,3,4,5-tetrabromopyrrole	Pseudoalteromonas piscicida
BGC0000259.3	0.39	PKS	prodigiosin	Serratia marcescens
BGC0002147.2	0.38	NRPS	bohemamine A, bohemamine B, bohemamine C	Streptomyces sp. CB02009

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.06 out of 19.26

Confidence: strong

Additional weak hits (2):

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 18.69 out of 30.12

Confidence: weak

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 17.04 out of 30.12

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein

NZ_WBPC01000018.1 - Region 2 - RiPP-like

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Location: 71,676 - 81,984 nt. (total: 10,309 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

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Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: aminotransferase

F8159_RS13105: aminotransferase

smcogs: SMCOG1019: aminotransferase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000896.5	0.29	other (other)	cycloserine	Streptomyces lavendulae subsp. lavendulae
BGC0000721.4	0.26	saccharide	tobramycin	Streptoalloteichus tenebrarius
BGC0000172.5	0.23	PKS	Basiliskamide A, Basiliskamide B	Brevibacillus laterosporus PE36
BGC0000381.5	0.23	NRPS	lichenysin	Bacillus licheniformis DSM 13 = ATCC 14580
BGC0000433.5	0.22	NRPS	surfactin	Bacillus velezensis FZB42
BGC0000455.6	0.22	NRPS, saccharide	vancomycin	Amycolatopsis orientalis HCCB10007 (ATCC43491)
BGC0002588.2	0.22	other (other)	enduracididine	uncultured bacterium
BGC0001233.5	0.22	NRPS	feglymycin	Streptomyces sp. DSM 11171
BGC0001461.5	0.21	NRPS	Actinoidin B	Amycolatopsis keratiniphila subsp. nogabecina
BGC0001459.5	0.21	NRPS	decaplanin	Amycolatopsis regifaucium

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000896.5	0.29	other (other)	cycloserine	Streptomyces lavendulae subsp. lavendulae
BGC0000721.4	0.26	saccharide	tobramycin	Streptoalloteichus tenebrarius
BGC0000172.5	0.23	PKS	Basiliskamide A, Basiliskamide B	Brevibacillus laterosporus PE36
BGC0000381.5	0.23	NRPS	lichenysin	Bacillus licheniformis DSM 13 = ATCC 14580
BGC0000433.5	0.22	NRPS	surfactin	Bacillus velezensis FZB42
BGC0000455.6	0.22	NRPS, saccharide	vancomycin	Amycolatopsis orientalis HCCB10007 (ATCC43491)
BGC0002588.2	0.22	other (other)	enduracididine	uncultured bacterium
BGC0001233.5	0.22	NRPS	feglymycin	Streptomyces sp. DSM 11171
BGC0001461.5	0.21	NRPS	Actinoidin B	Amycolatopsis keratiniphila subsp. nogabecina
BGC0001459.5	0.21	NRPS	decaplanin	Amycolatopsis regifaucium

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.87 out of 32.93

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.22 out of 24.78

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.30 out of 26.06

Confidence: medium

Additional weak hits (2):

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.27 out of 25.75

Confidence: weak

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 17.35 out of 30.12

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
LexA variant 2	Repressor of DNA damage response
LexA variant 3	Repressor of DNA damage response
MogR	Repressor of flagellar motility genes

NZ_WBPC01000018.1 - Region 3 - RiPP-like

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Location: 172,067 - 182,312 nt. (total: 10,246 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

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Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: hydrolase

F8159_RS13675: beta-lactamase

smcogs: SMCOG1053: beta-lactamase

Similar gene clusters

No matches found.

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

NZ_WBPC01000018.1 - Region 4 - NRPS

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Location: 203,101 - 250,116 nt. (total: 47,016 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

F8159_RS13850: FAD dependent oxidoreductase

smcogs: SMCOG1103: FAD dependent oxidoreductase

F8159_RS13985: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Transferases: aminotransferase

F8159_RS13980: aminotransferase

smcogs: SMCOG1019: aminotransferase

Hydrolases: esterase glucanase hydrolase

F8159_RS13915: alpha/beta hydrolase domain-containing protein

smcogs: SMCOG1066: alpha/beta hydrolase domain-containing protein

F8159_RS13935: Pullulanase, type I

smcogs: SMCOG1297: Pullulanase, type I

F8159_RS13945: 2`,3`-cyclic-nucleotide 2`-phosphodiesterase

smcogs: SMCOG1283: 2`,3`-cyclic-nucleotide 2`-phosphodiesterase

F8159_RS13990: alpha/beta hydrolase fold protein

smcogs: SMCOG1036: alpha/beta hydrolase fold protein

Lyases: decarboxylase

F8159_RS13920: Decarboxylase, pyridoxal-dependent

smcogs: SMCOG1180: Decarboxylase, pyridoxal-dependent

Ligases: ligase

F8159_RS13925: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001166.5	0.60	NRPS	HC-toxin	Alternaria jesenskae
BGC0002135.2	0.60	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001240.4	0.60	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0001135.5	0.60	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0002286.3	0.60	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001250.4	0.60	NRPS	epichloenin A	Epichloe festucae
BGC0001251.4	0.60	NRPS	epichloenin A	Epichloe festucae
BGC0000357.5	0.59	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0001825.4	0.59	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001249.5	0.59	NRPS	dimethylcoprogen	Alternaria alternata

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001166.5	0.60	NRPS	HC-toxin	Alternaria jesenskae
BGC0002135.2	0.60	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001240.4	0.60	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0001135.5	0.60	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0002286.3	0.60	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001250.4	0.60	NRPS	epichloenin A	Epichloe festucae
BGC0001251.4	0.60	NRPS	epichloenin A	Epichloe festucae
BGC0000357.5	0.59	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0001825.4	0.59	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001249.5	0.59	NRPS	dimethylcoprogen	Alternaria alternata

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.93 out of 30.25

Confidence: medium

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 24.13 out of 29.25

Confidence: medium

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 28.23 out of 31.73

Confidence: medium

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.66 out of 25.88

Confidence: medium

Additional weak hits (5):

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.02 out of 32.74

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.69 out of 31.73

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.46 out of 31.73

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 23.36 out of 33.73

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 22.63 out of 29.65

Confidence: weak

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS substrates

TFBS Finder

NRPS/PKS substrate predictions

F8159_RS13925: X

AMP-binding (268..647): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: FVMAFDISLLELESLLAGELNIYGPTETTICSTV
Nearest Stachelhaus code(s):: Ala DILICALICK (41% 8Å match)
Stachelhaus code match:: 70% (weak)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
ColR	Phenol-responsive regulator
HexR	Glucose-responsive regulator
PsrA	Oleic acid responsive regulator
SypG	Regulator of biofilm formation and host colonization

NZ_WBPC01000023.1 - Region 1 - NRPS-like

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Location: 1 - 40,357 nt. (total: 40,357 nt) Show pHMM detection rules used

Region on contig edge.

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidase

F8159_RS15905: FAD linked oxidase domain protein

smcogs: SMCOG1138: FAD linked oxidase domain protein

Transferases: phosphorylase phosphotransferase

F8159_RS15870: thiamine-phosphate pyrophosphorylase

smcogs: SMCOG1280: thiamine-phosphate pyrophosphorylase

F8159_RS15895: Glucose-specific phosphotransferase enzyme IIA

smcogs: SMCOG1145: Glucose-specific phosphotransferase enzyme IIA

Hydrolases: glucosidase

F8159_RS15900: Alpha-glucosidase

smcogs: SMCOG1257: Alpha-glucosidase

Ligases: ligase

F8159_RS15855: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.61	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0000307.4	0.60	NRPS	AbT1	Aureobasidium pullulans
BGC0001132.4	0.60	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.4	0.60	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001166.5	0.60	NRPS	HC-toxin	Alternaria jesenskae
BGC0002286.3	0.60	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001261.3	0.60	NRPS	AM-toxin	Alternaria alternata
BGC0001758.4	0.60	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0000357.5	0.60	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0001250.4	0.60	NRPS	epichloenin A	Epichloe festucae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.61	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0000307.4	0.60	NRPS	AbT1	Aureobasidium pullulans
BGC0001132.4	0.60	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.4	0.60	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001166.5	0.60	NRPS	HC-toxin	Alternaria jesenskae
BGC0002286.3	0.60	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001261.3	0.60	NRPS	AM-toxin	Alternaria alternata
BGC0001758.4	0.60	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0000357.5	0.60	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0001250.4	0.60	NRPS	epichloenin A	Epichloe festucae

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 24.83 out of 27.78

Confidence: strong

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 22.91 out of 25.88

Confidence: medium

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 22.91 out of 25.88

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.81 out of 20.97

Confidence: medium

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.69 out of 21.55

Confidence: strong

Additional weak hits (9):

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.13 out of 25.88

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.13 out of 25.88

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.70 out of 25.75

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.89 out of 30.25

Confidence: weak

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.11 out of 20.47

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.78 out of 31.73

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 21.58 out of 26.12

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.62 out of 29.25

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 24.98 out of 33.14

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 0 - 40357:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

F8159_RS15855: X

AMP-binding (225..621): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LWMPFDASVWEAALAIGGEHNVYGPTECTVVTTT
Nearest Stachelhaus code(s):: Leu DAWYLGNVVK (71% 8Å match)
Stachelhaus code match:: 70% (weak)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
ArcA	Repressor of carbon oxidation
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
PsrA	Oleic acid responsive regulator

NZ_WBPC01000024.1 - Region 1 - CDPS

Download region GenBank file

Download region SVG

Location: 32,642 - 53,361 nt. (total: 20,720 nt) Show pHMM detection rules used

CDPS: CDPS

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidase oxidoreductase oxygenase

F8159_RS16105: FAD dependent oxidoreductase

smcogs: SMCOG1103: FAD dependent oxidoreductase

F8159_RS16145: FAD linked oxidase domain protein

smcogs: SMCOG1138: FAD linked oxidase domain protein

F8159_RS16155: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002103.2	0.71	other (other)	pulcherriminic acid	Bacillus subtilis subsp. subtilis str. 168
BGC0001286.3	0.49	other (other)	itaconic acid	Ustilago maydis
BGC0001336.5	0.43	other (other)	erdasporine A, erdasporine B, erdasporine C	uncultured bacterium
BGC0000470.6	0.39	ribosomal	bottromycin D	Streptomyces sp. WMMB272
BGC0002211.3	0.34	PKS	HEx-pks1 polyketide	Paraphaeosphaeria sporulosa
BGC0001529.5	0.34	other (other)	benzastatin J, 7-hydroxyl benzastatin B, 7-hydroxyl O-demethylbenzastatin A, JBIR-67, 7-hydroxyl benzastatin F, 7-hydroxyl O-demethylbenzastatin D, O-demethylvirantmycin, 7-hydroxyl benzastatin D, virantmycin, benzastatin K, methylbenzastatin K	Streptomyces sp. RI18
BGC0001334.5	0.33	other (other)	caldoniamide A, cladoniamide B, cladoniamide C7, cladoniamide D, cladoniamide E, cladoniamide F, cladoniamide G	Streptomyces uncialis
BGC0000306.5	0.33	NRPS	arylomycin	Streptomyces filamentosus NRRL 11379
BGC0002205.2	0.33	NRPS, PKS	phomacin D, phomacin E	Parastagonospora nodorum SN15
BGC0000405.5	0.32	NRPS	δ-(L-α-aminoadipyl)-L-cysteine-D-valine, isopenicillin N, benzylpenicillin, phenoxymethylpenicillin	Penicillium chrysogenum

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002103.2	0.71	other (other)	pulcherriminic acid	Bacillus subtilis subsp. subtilis str. 168
BGC0001286.3	0.49	other (other)	itaconic acid	Ustilago maydis
BGC0001336.5	0.43	other (other)	erdasporine A, erdasporine B, erdasporine C	uncultured bacterium
BGC0000470.6	0.39	ribosomal	bottromycin D	Streptomyces sp. WMMB272
BGC0002211.3	0.34	PKS	HEx-pks1 polyketide	Paraphaeosphaeria sporulosa
BGC0001529.5	0.34	other (other)	benzastatin J, 7-hydroxyl benzastatin B, 7-hydroxyl O-demethylbenzastatin A, JBIR-67, 7-hydroxyl benzastatin F, 7-hydroxyl O-demethylbenzastatin D, O-demethylvirantmycin, 7-hydroxyl benzastatin D, virantmycin, benzastatin K, methylbenzastatin K	Streptomyces sp. RI18
BGC0001334.5	0.33	other (other)	caldoniamide A, cladoniamide B, cladoniamide C7, cladoniamide D, cladoniamide E, cladoniamide F, cladoniamide G	Streptomyces uncialis
BGC0000306.5	0.33	NRPS	arylomycin	Streptomyces filamentosus NRRL 11379
BGC0002205.2	0.33	NRPS, PKS	phomacin D, phomacin E	Parastagonospora nodorum SN15
BGC0000405.5	0.32	NRPS	δ-(L-α-aminoadipyl)-L-cysteine-D-valine, isopenicillin N, benzylpenicillin, phenoxymethylpenicillin	Penicillium chrysogenum

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.98 out of 20.97

Confidence: strong

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.28 out of 23.05

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.08 out of 23.79

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.80 out of 29.38

Confidence: medium

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 28.70 out of 33.14

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.97 out of 24.78

Confidence: medium

Additional weak hits (3):

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.80 out of 32.74

Confidence: weak

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 15.99 out of 20.47

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 25.63 out of 35.63

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production
CcpA	Catabolite control protein A
FuR variant 1	Ferric Uptake Regulator
IolR	Regulator of the inositol catabolism
LexA variant 2	Repressor of DNA damage response
ZuR variant 2	Zinc-responsive repressor

NZ_WBPC01000027.1 - Region 1 - lanthipeptide-class-ii

Download region GenBank file

Download region SVG

Location: 379,712 - 393,061 nt. (total: 13,350 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: cyclase

F8159_RS19565: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000502.5	0.48	ribosomal	cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7	Bacillus cereus
BGC0000525.5	0.45	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000554.4	0.42	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000504.5	0.38	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000500.5	0.37	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0001210.5	0.36	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000516.4	0.35	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0000527.5	0.34	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0000517.4	0.34	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0001407.5	0.33	ribosomal	bicereucin	Bacillus cereus SJ1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000502.5	0.48	ribosomal	cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7	Bacillus cereus
BGC0000525.5	0.45	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000554.4	0.42	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000504.5	0.38	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000500.5	0.37	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0001210.5	0.36	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000516.4	0.35	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0000527.5	0.34	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0000517.4	0.34	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0001407.5	0.33	ribosomal	bicereucin	Bacillus cereus SJ1

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for F8159_RS19565

F8159_RS19495

Leader:

MTVIASVKTCLASVRGA

Core:

QASLSSLSLNSTDDEAKRVFHECMLEMDSVITDLKDRVSVLEREEPQYKGF

Core with dehydrations:

QADhaLDhaDhaLDhaLNDhaDhbDDEAKRVFHECysMLEMDDhaVIDhbDLKDRVDhaVLEREEPQYKGF

antiSMASH-DB 4.0 matches for F8159_RS19495

100.0%

NZ_JH792105.1and 4 others:

NZ_WBOZ01000055.1 Lanthipeptides: F8156_RS20610_lanthipeptideNZ_WBPC01000027.1 Lanthipeptides: F8159_RS19495_lanthipeptideNZ_WBPE01000025.1 Lanthipeptides: F8161_RS14485_lanthipeptideNZ_WBPK01000016.1 Lanthipeptides: F8167_RS15635_lanthipeptide

Lanthipeptides: II5_RS26915_lanthipeptide

1

QASLSSLSLNSTDDEAKRVFHECMLEMDSVITDLKDRVSVLEREEPQYKGF

51

QASLSSLSLNSTDDEAKRVFHECMLEMDSVITDLKDRVSVLEREEPQYKGF

1

QASLSSLSLNSTDDEAKRVFHECMLEMDSVITDLKDRVSVLEREEPQYKGF

51

90.2%

NZ_CP067069.1:

Lanthipeptides: JCR32_RS24660_lanthipeptide

1

QASLSSLSLNSTDDEAKRVFHECMLEMDSVITDLKDRVSVLEREEPQYKGF

51

QASLSSLSLN+TDDEAKRVFHECMLEMDS+I DL++RVSVLEREEPQYKGF

1

QASLSSLSLNATDDEAKRVFHECMLEMDSIIVDLQNRVSVLEREEPQYKGF

51

86.3%

NZ_CP085413.1and 1 other:

NZ_JH792240.1 Lanthipeptides: IIK_RS26210_lanthipeptide

Lanthipeptides: LIS80_RS25415_lanthipeptide

1

QASLSSLSLNSTDDEAKRVFHECMLEMDSVITDLKDRVSVLEREEPQYKGF

51

QASLSSLSLNS D+E+KRVFHECMLEMDS+I DL++RVSVLEREEPQYKGF

1

QASLSSLSLNSQDEESKRVFHECMLEMDSIIADLQNRVSVLEREEPQYKGF

51

with 4 more sequence matches

86.3%

NZ_LDKE01000067.1:

Lanthipeptides: ABB04_RS19895_lanthipeptide

1

QASLSSLSLNSTDDEAKRVFHECMLEMDSVITDLKDRVSVLEREEPQYKGF

51

QASLSSLSLNS D+E+KRVFHECMLEMDSVI DL++R+SVLEREEPQYKGF

1

QASLSSLSLNSQDEESKRVFHECMLEMDSVIADLQNRISVLEREEPQYKGF

51

86.3%

NZ_PIYQ01000022.1:

Lanthipeptides: CW365_RS08140_lanthipeptide

1

QASLSSLSLNSTDDEAKRVFHECMLEMDSVITDLKDRVSVLEREEPQYKGF

51

QASLSSLSLNS D+E KRVFHECMLEMDS+I DL++RVSVLEREEPQYKGF

1

QASLSSLSLNSQDEETKRVFHECMLEMDSIIADLQNRVSVLEREEPQYKGF

51

15.7%

NZ_CP116936.1:

Lanthipeptides: PCA76_RS13075_lanthipeptide

22

ECMLEMDSVITDLKDRVSVLEREEPQ

47

EC+ +D + TD++ +S+ +R + Q

12

ECLAHIDEIWTDMRP-LSLRQRMQSQ

36

13.7%

NZ_CP051884.1:

Lanthipeptides: allorf_3277747_3277950_lanthipeptide

37

RVSVLEREEPQYKGF

51

R++ ++REEP Y+G

8

RINSMQREEP-YQGL

21

F8159_RS19530

Leader:

MVKKFKFTKEELVEAWKDPQVREKLKDLPNHPSGKALNELSEEELAEIQGA

F8159_RS19535

Leader:

MTKGYKFTKEELVEAWKDPQVREKLKDLPKHPSGKALNELSEEELAEIQGA

F8159_RS19540

Leader:

MTKGYKFTKEELVEAWKDPQVREKLKDLPKHPSGKALNELSEEELAEIQGA

F8159_RS19545

Leader:

MTKGYKFTKEELVEAWKDPQVREKLKDLPKHPSGKALNELSEEELAEIQGA

F8159_RS19550

Leader:

MTKGYKFTKEELVEAWKDPQVREKLKDLPKHPSGKALNELSEEELAGIQGA

F8159_RS19555

Leader:

DPQVREKLKDLPKHPSGKALNELSEEELAEIQGA

Shared core:

SDVQPETTPLCVGVIIGLTTSIKICK

Core with dehydrations:

DhaDVQPEDhbDhbPLCysVGVIIGLDhbDhbDhaIKICysK

antiSMASH-DB 4.0 matches for F8159_RS19530

100.0%

NZ_CP067069.1and 33 others:

NZ_CP085413.1 Lanthipeptides: LIS80_RS25380_lanthipeptideNZ_CP085413.1 Lanthipeptides: LIS80_RS25375_lanthipeptideNZ_CP085413.1 Lanthipeptides: LIS80_RS25370_lanthipeptideNZ_CP085413.1 Lanthipeptides: LIS80_RS25365_lanthipeptideNZ_CP085413.1 Lanthipeptides: LIS80_RS25360_lanthipeptideNZ_CP085413.1 Lanthipeptides: LIS80_RS25355_lanthipeptideNZ_JH792105.1 Lanthipeptides: II5_RS26955_lanthipeptideNZ_LDKE01000067.1 Lanthipeptides: ABB04_RS19955_lanthipeptideNZ_LDKE01000067.1 Lanthipeptides: ABB04_RS19940_lanthipeptideNZ_LDKE01000067.1 Lanthipeptides: ABB04_RS19935_lanthipeptideNZ_MOOT01000061.1 Lanthipeptides: BK765_RS23995_lanthipeptideNZ_MOOT01000061.1 Lanthipeptides: BK765_RS23990_lanthipeptideNZ_NVEA01000001.1 Lanthipeptides: COL15_RS00005_lanthipeptideNZ_PIYQ01000022.1 Lanthipeptides: CW365_RS08185_lanthipeptideNZ_PIYQ01000022.1 Lanthipeptides: CW365_RS08180_lanthipeptideNZ_PIYQ01000022.1 Lanthipeptides: CW365_RS08175_lanthipeptideNZ_WBOZ01000055.1 Lanthipeptides: F8156_RS20670_lanthipeptideNZ_WBOZ01000055.1 Lanthipeptides: F8156_RS20665_lanthipeptideNZ_WBOZ01000055.1 Lanthipeptides: F8156_RS20660_lanthipeptideNZ_WBOZ01000055.1 Lanthipeptides: F8156_RS20655_lanthipeptideNZ_WBOZ01000055.1 Lanthipeptides: F8156_RS20650_lanthipeptideNZ_WBOZ01000055.1 Lanthipeptides: F8156_RS20645_lanthipeptideNZ_WBPC01000027.1 Lanthipeptides: F8159_RS19555_lanthipeptideNZ_WBPC01000027.1 Lanthipeptides: F8159_RS19550_lanthipeptideNZ_WBPC01000027.1 Lanthipeptides: F8159_RS19545_lanthipeptideNZ_WBPC01000027.1 Lanthipeptides: F8159_RS19540_lanthipeptideNZ_WBPC01000027.1 Lanthipeptides: F8159_RS19535_lanthipeptideNZ_WBPC01000027.1 Lanthipeptides: F8159_RS19530_lanthipeptideNZ_WBPE01000025.1 Lanthipeptides: F8161_RS14445_lanthipeptideNZ_WBPE01000025.1 Lanthipeptides: F8161_RS14440_lanthipeptideNZ_WBPK01000016.1 Lanthipeptides: F8167_RS15680_lanthipeptideNZ_WBPK01000016.1 Lanthipeptides: F8167_RS15675_lanthipeptideNZ_WBPK01000016.1 Lanthipeptides: F8167_RS15670_lanthipeptide

Lanthipeptides: JCR32_RS24625_lanthipeptide

1

SDVQPETTPLCVGVIIGLTTSIKICK

26

SDVQPETTPLCVGVIIGLTTSIKICK

1

SDVQPETTPLCVGVIIGLTTSIKICK

26

96.2%

NZ_CP016020.1:

Lanthipeptides: A9C19_RS17970_lanthipeptide

1

SDVQPETTPLCVGVIIGLTTSIKIC

25

SDVQPETTPLCVGVIIGLTTSIKIC

1

SDVQPETTPLCVGVIIGLTTSIKIC

25

92.3%

NZ_CP067069.1and 13 others:

NZ_CP085413.1 Lanthipeptides: LIS80_RS25350_lanthipeptideNZ_JH792105.1 Lanthipeptides: II5_RS26960_lanthipeptideNZ_JH792240.1 Lanthipeptides: IIK_RS26240_lanthipeptideNZ_MOOT01000061.1 Lanthipeptides: BK765_RS23985_lanthipeptideNZ_NTUF01000024.1 Lanthipeptides: CN379_RS26680_lanthipeptideNZ_NVCZ01000001.1 Lanthipeptides: COK75_RS01180_lanthipeptideNZ_NVDK01000008.1 Lanthipeptides: COK95_RS05665_lanthipeptideNZ_NVEA01000001.1 Lanthipeptides: COL15_RS00010_lanthipeptideNZ_PIYQ01000022.1 Lanthipeptides: CW365_RS08190_lanthipeptideNZ_WBOZ01000055.1 Lanthipeptides: F8156_RS20675_lanthipeptideNZ_WBPC01000027.1 Lanthipeptides: F8159_RS19560_lanthipeptideNZ_WBPE01000025.1 Lanthipeptides: F8161_RS14435_lanthipeptideNZ_WBPK01000016.1 Lanthipeptides: F8167_RS15685_lanthipeptide

Lanthipeptides: JCR32_RS24620_lanthipeptide

1

SDVQPETTPLCVGVIIGLTTSIKICK

26

SDVQPETTPLCVGVIIG+T SIKICK

1

SDVQPETTPLCVGVIIGITASIKICK

26

with 101 more sequence matches

Only the first 10 are displayed here.

88.5%

NZ_LDKE01000067.1:

Lanthipeptides: ABB04_RS19960_lanthipeptide

1

SDVQPETTPLCVGVIIGLTTSIKICK

26

SDV+PETTPLCVGVIIG+T SIKICK

1

SDVKPETTPLCVGVIIGITASIKICK

26

80.8%

NZ_JH792105.1:

Lanthipeptides: II5_RS26950_lanthipeptide

1

SDVQPETTPLCVGVIIGLTTS

21

SDVQPETTPLCVGVIIGLTTS

1

SDVQPETTPLCVGVIIGLTTS

21

75.0%

NZ_CP092966.1:

Lanthipeptides: KM149_RS02085_lanthipeptide

1

SDVQPETTPLCVGVIIGLTTSIKIC

25

SDV+PETTPLCVGVI GLT SIK C

1

SDVKPETTPLCVGVIAGLTYSIKKC

25

69.2%

NZ_JACSMH010000008.1and 2 others:

NZ_JACSMX010000006.1 Lanthipeptides: KNQ03_RS15615_lanthipeptideNZ_JACSMZ010000005.1 Lanthipeptides: KNQ06_RS16025_lanthipeptide

Lanthipeptides: KNP89_RS14470_lanthipeptide

1

SDVQPETTPLCVGVIIGLTTSIKICK

26

DVQPETTP CVGVI+G+T S+ CK

1

GDVQPETTPFCVGVIVGVTISLSKCK

26

61.5%

NZ_JACSPU010000002.1:

Lanthipeptides: H9630_RS06775_lanthipeptide

1

SDVQPETTPLCVGVII-GLTTSIKIC

25

SDV PETTP CV GL SIK C

1

SDVAPETTPACVAAFATGLLFSIKFC

26

61.5%

NZ_JAOVZP010000016.1and 3 others:

NZ_NHVL01000036.1 Lanthipeptides: CEU70_RS27720_lanthipeptideNZ_NTYE01000081.1 Lanthipeptides: CN490_RS28165_lanthipeptideNZ_NVMN01000027.1 Lanthipeptides: CON30_RS23205_lanthipeptide

Lanthipeptides: OF830_RS26725_lanthipeptide

1

SDVQPETTPLCV-GVIIGLTTSIKIC

25

SDVQPETTP CV + G+ SIK C

1

SDVQPETTPACVTALTTGIIFSIKWC

26

60.7%

NZ_CP062165.1and 5 others:

NZ_CP062165.1 Lanthipeptides: JNUCC31_RS17170_lanthipeptideNZ_QICW01000005.1 Lanthipeptides: DEU73_RS14620_lanthipeptideNZ_QICW01000005.1 Lanthipeptides: DEU73_RS14620_lanthipeptideNZ_QLLI01000007.1 Lanthipeptides: DET54_RS17335_lanthipeptideNZ_QLLI01000007.1 Lanthipeptides: DET54_RS17335_lanthipeptide

Lanthipeptides: JNUCC31_RS17170_lanthipeptide

1

SDVQPETTPLC---VGVIIGLTTSIKIC

25

+DVQPETTPLC VGV IG+ S+ C

1

ADVQPETTPLCGFLVGVGIGVILSVTSC

28

60.7%

NZ_LN831278.1:

Lanthipeptides: BN1360_RS08840_lanthipeptide

1

SDVQPETTPLC---VGVIIGLTTSIKIC

25

+DVQPETTPLC VGV IG+ S+ C

1

ADVQPETTPLCGFFVGVGIGVILSVAKC

28

59.3%

NZ_JAHHYI010000012.1:

Lanthipeptides: KM925_RS25405_lanthipeptide

1

SDVQPETTPLCVGVIIGLTTSIKICK

26

DVQPETTP CVG G+T I I K

1

GDVQPETTPACVGA--GITVGIAISK

24

58.6%

NZ_JAOVZP010000016.1and 3 others:

NZ_NHVL01000036.1 Lanthipeptides: CEU70_RS27725_lanthipeptideNZ_NTYE01000081.1 Lanthipeptides: CN490_RS28170_lanthipeptideNZ_NVMN01000027.1 Lanthipeptides: CON30_RS23200_lanthipeptide

Lanthipeptides: OF830_RS26730_lanthipeptide

1

SDVQPETTPLC-VGVIIGLTT--SIKICK

26

SDVQPETTP C V IG T S++ CK

1

SDVQPETTPACAVAFTIGATVIFSVRNCK

29

MIBiG 4.0 matches for F8159_RS19530

19.2%

BGC0000580.3 (EGD17355.1):

Lasso peptide: xanthomonin II or xanthomonin I

9

PLCVGVIIGLTT

20

PL + G+TT

3

PLAGEEMGGITT

14

13.5%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

7

TTPLCVGVIIGL

18

T P G+I+G+

1

TDPAVTGLILGI

12

11.8%

BGC0000535.4 (ADJ56352.1):

Lanthipeptide: nisin A

20

TSIKIC

25

TSI +C

2

TSISLC

7

F8159_RS19560

Leader:

MSKEYKFTKEELVEAWKDPQVREKLKDLPKHPSGKALNELSEEELAEIQGA

Core:

SDVQPETTPLCVGVIIGITASIKICK

Core with dehydrations:

DhaDVQPEDhbDhbPLCysVGVIIGIDhbADhaIKICysK

antiSMASH-DB 4.0 matches for F8159_RS19560

100.0%

NZ_CP067069.1and 13 others:

NZ_CP085413.1 Lanthipeptides: LIS80_RS25350_lanthipeptideNZ_JH792105.1 Lanthipeptides: II5_RS26960_lanthipeptideNZ_JH792240.1 Lanthipeptides: IIK_RS26240_lanthipeptideNZ_MOOT01000061.1 Lanthipeptides: BK765_RS23985_lanthipeptideNZ_NTUF01000024.1 Lanthipeptides: CN379_RS26680_lanthipeptideNZ_NVCZ01000001.1 Lanthipeptides: COK75_RS01180_lanthipeptideNZ_NVDK01000008.1 Lanthipeptides: COK95_RS05665_lanthipeptideNZ_NVEA01000001.1 Lanthipeptides: COL15_RS00010_lanthipeptideNZ_PIYQ01000022.1 Lanthipeptides: CW365_RS08190_lanthipeptideNZ_WBOZ01000055.1 Lanthipeptides: F8156_RS20675_lanthipeptideNZ_WBPC01000027.1 Lanthipeptides: F8159_RS19560_lanthipeptideNZ_WBPE01000025.1 Lanthipeptides: F8161_RS14435_lanthipeptideNZ_WBPK01000016.1 Lanthipeptides: F8167_RS15685_lanthipeptide

Lanthipeptides: JCR32_RS24620_lanthipeptide

1

SDVQPETTPLCVGVIIGITASIKICK

26

SDVQPETTPLCVGVIIGITASIKICK

1

SDVQPETTPLCVGVIIGITASIKICK

26

96.2%

NZ_LDKE01000067.1:

Lanthipeptides: ABB04_RS19960_lanthipeptide

1

SDVQPETTPLCVGVIIGITASIKICK

26

SDV+PETTPLCVGVIIGITASIKICK

1

SDVKPETTPLCVGVIIGITASIKICK

26

92.3%

NZ_CP067069.1and 33 others:

NZ_CP085413.1 Lanthipeptides: LIS80_RS25380_lanthipeptideNZ_CP085413.1 Lanthipeptides: LIS80_RS25375_lanthipeptideNZ_CP085413.1 Lanthipeptides: LIS80_RS25370_lanthipeptideNZ_CP085413.1 Lanthipeptides: LIS80_RS25365_lanthipeptideNZ_CP085413.1 Lanthipeptides: LIS80_RS25360_lanthipeptideNZ_CP085413.1 Lanthipeptides: LIS80_RS25355_lanthipeptideNZ_JH792105.1 Lanthipeptides: II5_RS26955_lanthipeptideNZ_LDKE01000067.1 Lanthipeptides: ABB04_RS19955_lanthipeptideNZ_LDKE01000067.1 Lanthipeptides: ABB04_RS19940_lanthipeptideNZ_LDKE01000067.1 Lanthipeptides: ABB04_RS19935_lanthipeptideNZ_MOOT01000061.1 Lanthipeptides: BK765_RS23995_lanthipeptideNZ_MOOT01000061.1 Lanthipeptides: BK765_RS23990_lanthipeptideNZ_NVEA01000001.1 Lanthipeptides: COL15_RS00005_lanthipeptideNZ_PIYQ01000022.1 Lanthipeptides: CW365_RS08185_lanthipeptideNZ_PIYQ01000022.1 Lanthipeptides: CW365_RS08180_lanthipeptideNZ_PIYQ01000022.1 Lanthipeptides: CW365_RS08175_lanthipeptideNZ_WBOZ01000055.1 Lanthipeptides: F8156_RS20670_lanthipeptideNZ_WBOZ01000055.1 Lanthipeptides: F8156_RS20665_lanthipeptideNZ_WBOZ01000055.1 Lanthipeptides: F8156_RS20660_lanthipeptideNZ_WBOZ01000055.1 Lanthipeptides: F8156_RS20655_lanthipeptideNZ_WBOZ01000055.1 Lanthipeptides: F8156_RS20650_lanthipeptideNZ_WBOZ01000055.1 Lanthipeptides: F8156_RS20645_lanthipeptideNZ_WBPC01000027.1 Lanthipeptides: F8159_RS19555_lanthipeptideNZ_WBPC01000027.1 Lanthipeptides: F8159_RS19550_lanthipeptideNZ_WBPC01000027.1 Lanthipeptides: F8159_RS19545_lanthipeptideNZ_WBPC01000027.1 Lanthipeptides: F8159_RS19540_lanthipeptideNZ_WBPC01000027.1 Lanthipeptides: F8159_RS19535_lanthipeptideNZ_WBPC01000027.1 Lanthipeptides: F8159_RS19530_lanthipeptideNZ_WBPE01000025.1 Lanthipeptides: F8161_RS14445_lanthipeptideNZ_WBPE01000025.1 Lanthipeptides: F8161_RS14440_lanthipeptideNZ_WBPK01000016.1 Lanthipeptides: F8167_RS15680_lanthipeptideNZ_WBPK01000016.1 Lanthipeptides: F8167_RS15675_lanthipeptideNZ_WBPK01000016.1 Lanthipeptides: F8167_RS15670_lanthipeptide

Lanthipeptides: JCR32_RS24625_lanthipeptide

1

SDVQPETTPLCVGVIIGITASIKICK

26

SDVQPETTPLCVGVIIG+T SIKICK

1

SDVQPETTPLCVGVIIGLTTSIKICK

26

with 110 more sequence matches

Only the first 10 are displayed here.

88.5%

NZ_CP016020.1:

Lanthipeptides: A9C19_RS17970_lanthipeptide

1

SDVQPETTPLCVGVIIGITASIKIC

25

SDVQPETTPLCVGVIIG+T SIKIC

1

SDVQPETTPLCVGVIIGLTTSIKIC

25

73.1%

NZ_JH792105.1:

Lanthipeptides: II5_RS26950_lanthipeptide

1

SDVQPETTPLCVGVIIGITAS

21

SDVQPETTPLCVGVIIG+T S

1

SDVQPETTPLCVGVIIGLTTS

21

71.4%

NZ_CP092966.1:

Lanthipeptides: KM149_RS02085_lanthipeptide

1

SDVQPETTPLCVGVIIGITASIKIC

25

SDV+PETTPLCVGVI G+T SIK C

1

SDVKPETTPLCVGVIAGLTYSIKKC

25

69.2%

NZ_JACSMH010000008.1and 2 others:

NZ_JACSMX010000006.1 Lanthipeptides: KNQ03_RS15615_lanthipeptideNZ_JACSMZ010000005.1 Lanthipeptides: KNQ06_RS16025_lanthipeptide

Lanthipeptides: KNP89_RS14470_lanthipeptide

2

DVQPETTPLCVGVIIGITASIKICK

26

DVQPETTP CVGVI+G+T S+ CK

2

DVQPETTPFCVGVIVGVTISLSKCK

26

65.4%

NZ_JAOVZP010000016.1and 3 others:

NZ_NHVL01000036.1 Lanthipeptides: CEU70_RS27720_lanthipeptideNZ_NTYE01000081.1 Lanthipeptides: CN490_RS28165_lanthipeptideNZ_NVMN01000027.1 Lanthipeptides: CON30_RS23205_lanthipeptide

Lanthipeptides: OF830_RS26725_lanthipeptide

1

SDVQPETTPLCV-GVIIGITASIKIC

25

SDVQPETTP CV + GI SIK C

1

SDVQPETTPACVTALTTGIIFSIKWC

26

63.0%

NZ_JAHHYI010000012.1:

Lanthipeptides: KM925_RS25405_lanthipeptide

1

SDVQPETTPLCVGVIIGITASIKICK

26

DVQPETTP CVG GIT I I K

1

GDVQPETTPACVGA--GITVGIAISK

24

60.7%

NZ_CP062165.1and 5 others:

NZ_CP062165.1 Lanthipeptides: JNUCC31_RS17170_lanthipeptideNZ_QICW01000005.1 Lanthipeptides: DEU73_RS14620_lanthipeptideNZ_QICW01000005.1 Lanthipeptides: DEU73_RS14620_lanthipeptideNZ_QLLI01000007.1 Lanthipeptides: DET54_RS17335_lanthipeptideNZ_QLLI01000007.1 Lanthipeptides: DET54_RS17335_lanthipeptide

Lanthipeptides: JNUCC31_RS17170_lanthipeptide

1

SDVQPETTPLC---VGVIIGITASIKIC

25

+DVQPETTPLC VGV IG+ S+ C

1

ADVQPETTPLCGFLVGVGIGVILSVTSC

28

60.7%

NZ_JAOVZP010000016.1and 1 other:

NZ_JAOVZP010000016.1 Lanthipeptides: OF830_RS26675_lanthipeptide

Lanthipeptides: OF830_RS26680_lanthipeptide

1

SDVQPETTPLC--VGVIIGITASIKICK

26

DV PETTPLC +GV GI S ICK

1

GDVSPETTPLCITIGVGGGIAISKLICK

28

60.7%

NZ_LN831278.1:

Lanthipeptides: BN1360_RS08840_lanthipeptide

1

SDVQPETTPLC---VGVIIGITASIKIC

25

+DVQPETTPLC VGV IG+ S+ C

1

ADVQPETTPLCGFFVGVGIGVILSVAKC

28

59.3%

NZ_FTML01000041.1:

Lanthipeptides: BW937_RS20030_lanthipeptide

1

SDVQPETTPLCVGVIIGITASIKICK

26

DVQPE+TP CVG GIT I I K

1

GDVQPESTPACVGA--GITVGIAISK

24

MIBiG 4.0 matches for F8159_RS19560

18.9%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

7

TTPLCVGVIIGITA

20

T P G+I+GI A

1

TDPAVTGLILGIVA

14

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.33 out of 26.06

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.99 out of 26.06

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 17.07 out of 18.16

Confidence: strong

Additional weak hits (2):

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 20.68 out of 26.12

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 25.03 out of 31.73

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

F8159_RS19495 - Class II

Cleavage pHMM score: -3.60

RODEO score: 0

Monoisotopic mass: 5682.8 Da

Molecular weight: 5686.3 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 5704.3 Da N = 1; 5722.3 Da N = 2; 5740.3 Da N = 3; 5758.4 Da N = 4; 5776.4 Da N = 5; 5794.4 Da N = 6; 5812.4 Da N = 7; 5830.4 Da N = 8

F8159_RS19530 - Class II

Cleavage pHMM score: 4.20

RODEO score: 0

Monoisotopic mass: 2606.5 Da

Molecular weight: 2608.1 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 2626.1 Da N = 1; 2644.1 Da N = 2; 2662.2 Da N = 3; 2680.2 Da N = 4

F8159_RS19535 - Class II

Cleavage pHMM score: 4.20

RODEO score: 0

Monoisotopic mass: 2606.5 Da

Molecular weight: 2608.1 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 2626.1 Da N = 1; 2644.1 Da N = 2; 2662.2 Da N = 3; 2680.2 Da N = 4

F8159_RS19540 - Class II

Cleavage pHMM score: 4.20

RODEO score: 0

Monoisotopic mass: 2606.5 Da

Molecular weight: 2608.1 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 2626.1 Da N = 1; 2644.1 Da N = 2; 2662.2 Da N = 3; 2680.2 Da N = 4

F8159_RS19545 - Class II

Cleavage pHMM score: 4.20

RODEO score: 0

Monoisotopic mass: 2606.5 Da

Molecular weight: 2608.1 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 2626.1 Da N = 1; 2644.1 Da N = 2; 2662.2 Da N = 3; 2680.2 Da N = 4

F8159_RS19550 - Class II

Cleavage pHMM score: 2.50

RODEO score: 0

Monoisotopic mass: 2606.5 Da

Molecular weight: 2608.1 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 2626.1 Da N = 1; 2644.1 Da N = 2; 2662.2 Da N = 3; 2680.2 Da N = 4

F8159_RS19555 - Class II

Cleavage pHMM score: 4.20

RODEO score: 0

Monoisotopic mass: 2606.5 Da

Molecular weight: 2608.1 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 2626.1 Da N = 1; 2644.1 Da N = 2; 2662.2 Da N = 3; 2680.2 Da N = 4

F8159_RS19560 - Class II

Cleavage pHMM score: 4.20

RODEO score: 0

Monoisotopic mass: 2594.4 Da

Molecular weight: 2596.1 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 2614.1 Da N = 1; 2632.1 Da N = 2; 2650.2 Da N = 3

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
MogR	Repressor of flagellar motility genes

NZ_WBPC01000003.1 - Region 1 - NRP-metallophore,NRPS

Download region GenBank file

Download region SVG

Location: 201,470 - 253,218 nt. (total: 51,749 nt) Show pHMM detection rules used

NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

F8159_RS02745: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

F8159_RS02750: 3-hydroxyisobutyrate dehydrogenase

smcogs: SMCOG1100: 3-hydroxyisobutyrate dehydrogenase

F8159_RS02755: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

F8159_RS02810: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

F8159_RS02890: Antibiotic biosynthesis monooxygenase

smcogs: SMCOG1258: Antibiotic biosynthesis monooxygenase

Transferases: PPTase

F8159_RS02845: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1012: 4'-phosphopantetheinyl transferase

Hydrolases: hydrolase protease

F8159_RS02825: isochorismatase

smcogs: SMCOG1027: isochorismatase

F8159_RS02870: alkaline serine protease, subtilase family

smcogs: SMCOG1075: alkaline serine protease, subtilase family

Lyases: hydratase

F8159_RS02765: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

Isomerases: isomerase

F8159_RS02815: isochorismate synthase

smcogs: SMCOG1018: isochorismate synthase

Ligases: ligase synthase

F8159_RS02820: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

F8159_RS02830: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

F8159_RS02895: Pseudouridine synthase

smcogs: SMCOG1154: Pseudouridine synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001185.5	1.05	NRPS	bacillibactin	Bacillus velezensis FZB42
BGC0000309.5	0.89	NRPS	bacillibactin	Bacillus subtilis subsp. subtilis str. 168
BGC0000401.5	0.87	NRPS	paenibactin	Paenibacillus elgii B69
BGC0002075.3	0.86	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0000343.5	0.85	NRPS	enterobactin	Pseudomonas sp. J465
BGC0001132.4	0.77	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.4	0.75	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.74	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001128.4	0.74	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.72	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001185.5	0.80	NRPS	bacillibactin	Bacillus velezensis FZB42
BGC0000309.5	0.75	NRPS	bacillibactin	Bacillus subtilis subsp. subtilis str. 168
BGC0000401.5	0.74	NRPS	paenibactin	Paenibacillus elgii B69
BGC0002075.3	0.74	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0000343.5	0.74	NRPS	enterobactin	Pseudomonas sp. J465
BGC0001132.4	0.71	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.4	0.70	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.70	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001128.4	0.70	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.69	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 24.13 out of 27.78

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.53 out of 26.06

Confidence: strong

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 24.21 out of 30.25

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.53 out of 29.38

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.40 out of 29.38

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.41 out of 29.38

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.90 out of 29.38

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.62 out of 27.78

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.57 out of 27.78

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.56 out of 29.38

Confidence: medium

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 26.57 out of 32.74

Confidence: medium

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 25.99 out of 30.25

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.70 out of 26.06

Confidence: medium

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.21 out of 30.25

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.53 out of 28.19

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.98 out of 28.19

Confidence: medium

Additional weak hits (7):

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 25.83 out of 32.74

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.49 out of 29.38

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.05 out of 29.38

Confidence: weak

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 15.72 out of 18.46

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 25.23 out of 31.73

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.35 out of 31.73

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.54 out of 30.25

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 201469 - 253218:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Gly - Thr)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

F8159_RS02820: diOH-Bz

Search NORINE for peptide: strict or relaxed

AMP-binding (31..435): diOH-Bz

nrpys: diOH-Bz

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Small clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Single AA prediction:: dhb (diOH-Bz)

Stachelhaus prediction details:

Stachelhaus sequence:: SVSLYPMSSPGGALQVGGAQQVFGMAEGLVNYTR
Nearest Stachelhaus code(s):: diOH-Bz PMPAQGVVNK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

F8159_RS02830: Gly - Thr

Search NORINE for peptide: strict or relaxed

AMP-binding (464..864): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: gly (Gly)

Stachelhaus prediction details:

Stachelhaus sequence:: FAMTFDISALELQALVGGETNLYGPTETTIWSTF
Nearest Stachelhaus code(s):: Gly DILQLGLIWK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1524..1937): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: LATHFDFSVWEGNQVFGGEINMYGITETTVHVSY
Nearest Stachelhaus code(s):: Thr DFWNVGMVHK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
ColR	Phenol-responsive regulator
FuR variant 1	Ferric Uptake Regulator
FuR variant 2	Ferric Uptake Regulator
MogR	Repressor of flagellar motility genes
ZuR variant 1	Zinc-responsive repressor

NZ_WBPC01000005.1 - Region 1 - NRPS

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Location: 44,017 - 109,931 nt. (total: 65,915 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidase

F8159_RS03340: pyruvate oxidase/decarboxylase

smcogs: SMCOG1055: pyruvate oxidase/decarboxylase

F8159_RS03470: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: PPTase acetyltransferase acyltransferase

F8159_RS03420: Chloramphenicol acetyltransferase

smcogs: SMCOG1156: Chloramphenicol acetyltransferase

F8159_RS03430: acyltransferase 3

smcogs: SMCOG1088: acyltransferase 3

F8159_RS03460: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1012: 4'-phosphopantetheinyl transferase

Hydrolases: deacetylase esterase

F8159_RS03380: acetylornithine deacetylase

smcogs: SMCOG1247: acetylornithine deacetylase

F8159_RS03465: thioesterase

smcogs: SMCOG1004: thioesterase

Isomerases: mutase

F8159_RS03355: phosphoglycerate mutase

smcogs: SMCOG1101: phosphoglycerate mutase

Ligases: ligase

F8159_RS03445: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

F8159_RS03450: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

F8159_RS03455: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001833.4	0.75	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002135.2	0.74	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001128.4	0.73	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001133.4	0.73	NRPS	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0002075.3	0.73	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001758.4	0.73	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0002286.3	0.73	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5	0.73	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001132.4	0.73	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001825.4	0.72	NRPS	xenematide	Xenorhabdus nematophila AN6/1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001833.4	0.75	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002135.2	0.74	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001128.4	0.73	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001133.4	0.73	NRPS	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0002075.3	0.73	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001758.4	0.73	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0002286.3	0.73	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5	0.73	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001132.4	0.73	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001825.4	0.72	NRPS	xenematide	Xenorhabdus nematophila AN6/1

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.03 out of 26.06

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.21 out of 26.06

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57

Confidence: strong

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 26.19 out of 30.25

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.25 out of 24.78

Confidence: medium

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 18.20 out of 20.01

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.62 out of 23.79

Confidence: medium

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 25.07 out of 30.25

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 21.00 out of 24.78

Confidence: medium

Additional weak hits (6):

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 26.67 out of 31.73

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 22.38 out of 29.65

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 22.27 out of 36.53

Confidence: weak

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.58 out of 19.52

Confidence: weak

RicR

Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 20.97 out of 32.93

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.95 out of 20.01

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 44016 - 109931:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-Thr) + (X - Ala) + (Ser - Leu - D-X - Glu)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

F8159_RS03445: Thr

Search NORINE for peptide: strict or relaxed

AMP-binding (457..866): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: LSTHFDFSVWEGNQIFGGEINMYGITETTVHVTY
Nearest Stachelhaus code(s):: Thr DFWNIGMVHK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

F8159_RS03450: X - Ala

Search NORINE for peptide: strict or relaxed

AMP-binding (466..870): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: YWMTFDVSVWEWQFFSGGETNFYGPTEATIYVNA
Nearest Stachelhaus code(s):: Glu DVWHFGRINK (71% 8Å match); Gln DAWQFGLIDK (65% 8Å match)
Stachelhaus code match:: 70% (weak)

AMP-binding (1529..1921): Ala

nrpys: Ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: ala (Ala)

Stachelhaus prediction details:

Stachelhaus sequence:: MWATFDLSVFEVNTNLAGEYNLYGPSEDTTYSTY
Nearest Stachelhaus code(s):: Ala DLFNNALTYK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

F8159_RS03455: Ser - Leu - X - Glu

Search NORINE for peptide: strict or relaxed

AMP-binding (496..901): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: RWMTFDVSVWEWHFFTSGEINLYGPTEATVDVTY
Nearest Stachelhaus code(s):: Ser DVWHFSLVDK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1558..1945): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: leu (Leu)

Stachelhaus prediction details:

Stachelhaus sequence:: MWHAFDSAVQEPFAITGGDINQYGPSENTVVTTD
Nearest Stachelhaus code(s):: Pro DVQFIAQVVK (56% 8Å match)
Stachelhaus code match:: 80% (moderate)

AMP-binding (2600..3000): X

nrpys: Gln, Glu

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: glu,gln (Glu, Gln)
Single AA prediction:: glu (Glu)

Stachelhaus prediction details:

Stachelhaus sequence:: LGLAFDASIQQMDILVGGEYNVYGPTECTVDATC
Nearest Stachelhaus code(s):: Gln or Glu DAQDLGVVDK (88% 8Å match); Ile DAQDLGVVDK (85% 8Å match); Gln DAQDLGVVDK (79% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (4115..4515): Glu

nrpys: Glu

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: N/A
Single AA prediction:: glu (Glu)

Stachelhaus prediction details:

Stachelhaus sequence:: LGLAFDVSIQQMDMLVGGEYNVYGPTECTVDATC
Nearest Stachelhaus code(s):: Gln or Glu DAQDLGVVDK (85% 8Å match); Ile DAQDLGVVDK (82% 8Å match); Gln DAQDLGVVDK (76% 8Å match)
Stachelhaus code match:: 90% (moderate)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
ArgR	Regulator of arginine biosynthesis genes
ColR	Phenol-responsive regulator
IolR	Regulator of the inositol catabolism
LexA variant 2	Repressor of DNA damage response
MogR	Repressor of flagellar motility genes
ToxT	Regulator of MSHA biosynthesis

NZ_WBPC01000036.1 - Region 1 - lanthipeptide-class-ii

Download region GenBank file

Download region SVG

Location: 24,753 - 43,971 nt. (total: 19,219 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: cyclase

F8159_RS22535: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

F8159_RS22550: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001391.3	0.84	ribosomal	thusin	Bacillus thuringiensis serovar rongseni
BGC0000504.5	0.57	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000520.5	0.55	ribosomal	lacticin 3147 A1, lacticin 3147 A2	Lactococcus lactis
BGC0000623.3	0.54	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0001311.5	0.53	ribosomal	flavecins	Ruminococcus flavefaciens FD-1
BGC0000525.5	0.53	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000552.3	0.53	ribosomal	SmbA, SmbB	Streptococcus mutans
BGC0001229.4	0.53	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0002110.3	0.52	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0000539.5	0.52	ribosomal	nukacin ISK-1	Staphylococcus warneri

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001391.3	0.84	ribosomal	thusin	Bacillus thuringiensis serovar rongseni
BGC0000504.5	0.57	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000520.5	0.55	ribosomal	lacticin 3147 A1, lacticin 3147 A2	Lactococcus lactis
BGC0000623.3	0.54	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0001311.5	0.53	ribosomal	flavecins	Ruminococcus flavefaciens FD-1
BGC0000525.5	0.53	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000552.3	0.53	ribosomal	SmbA, SmbB	Streptococcus mutans
BGC0001229.4	0.53	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0002110.3	0.52	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0000539.5	0.52	ribosomal	nukacin ISK-1	Staphylococcus warneri

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for F8159_RS22535

F8159_RS30260

Leader:

MLDIIKNRKKVKENLELPDTLLEEVEEHSAMGG

Core:

INTWNTTATSTSIIISETFGNKGKVCTYTVECVNNCRG

Core with dehydrations:

INDhbWNDhbDhbADhbDhaDhbDhaIIIDhaEDhbFGNKGKVCysDhbYDhbVECysVNNCysRG

antiSMASH-DB 4.0 matches for F8159_RS30260

100.0%

NZ_CM000756.1and 7 others:

NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS34475_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS30450_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS30450_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS29770_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS29770_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS30260_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS30260_lanthipeptide

Lanthipeptides: BTHUR0011_RS34475_lanthipeptide

1

INTWNTTATSTSIIISETFGNKGKVCTYTVECVNNCRG

38

INTWNTTATSTSIIISETFGNKGKVCTYTVECVNNCRG

1

INTWNTTATSTSIIISETFGNKGKVCTYTVECVNNCRG

38

71.1%

NZ_JAGKQT010000007.1and 3 others:

NZ_JAGKQT010000007.1 Lanthipeptides: J2M30_RS09860_lanthipeptideNZ_LVYL01000010.1 Lanthipeptides: A3863_RS05855_lanthipeptideNZ_LVYL01000010.1 Lanthipeptides: A3863_RS05855_lanthipeptide

Lanthipeptides: J2M30_RS09860_lanthipeptide

2

NTWNTTATSTSIIISETFGNKGKVCTYTVECVNNCR

37

NTWNT +TST I +S GN GKVCTYTVECVNNCR

1

NTWNTISTSTCIAVSHFVGNDGKVCTYTVECVNNCR

36

63.2%

NZ_CP047645.1and 7 others:

NZ_CP047645.1 Lanthipeptides: GSN02_RS17445_lanthipeptideNZ_JALAUA010000003.1 Lanthipeptides: MOD32_RS04860_lanthipeptideNZ_JALAUA010000003.1 Lanthipeptides: MOD32_RS04860_lanthipeptideNZ_NJRE01000008.1 Lanthipeptides: CE047_RS18560_lanthipeptideNZ_NJRE01000008.1 Lanthipeptides: CE047_RS18560_lanthipeptideNZ_VIOH01000001.1 Lanthipeptides: FLN47_RS03725_lanthipeptideNZ_VIOH01000001.1 Lanthipeptides: FLN47_RS03725_lanthipeptide

Lanthipeptides: GSN02_RS17445_lanthipeptide

1

INTWNTTATST-SIIISETFGNKGKVCTYTVECVNNC

36

NTWNTT TS +I++SE FGNKGKVCT T EC C

1

FNTWNTTTTSVGTILVSEVFGNKGKVCTGTKECQGTC

37

with 103 more sequence matches

Only the first 10 are displayed here.

60.5%

NZ_CP017953.1and 27 others:

NZ_CP017953.1 Lanthipeptides: BAMY_RS16400_lanthipeptideNZ_CP021011.1 Lanthipeptides: B6257_RS06480_lanthipeptideNZ_CP021011.1 Lanthipeptides: B6257_RS06480_lanthipeptideNZ_CP033054.1 Lanthipeptides: D9777_RS18850_lanthipeptideNZ_CP033054.1 Lanthipeptides: D9777_RS18850_lanthipeptideNZ_CP041784.1 Lanthipeptides: FOV14_RS15900_lanthipeptideNZ_CP041784.1 Lanthipeptides: FOV14_RS15900_lanthipeptideNZ_CP047268.1 Lanthipeptides: GKS41_RS18615_lanthipeptideNZ_CP047268.1 Lanthipeptides: GKS41_RS18615_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS05705_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS05705_lanthipeptideNZ_CP072563.1 Lanthipeptides: J6600_RS15945_lanthipeptideNZ_CP072563.1 Lanthipeptides: J6600_RS15945_lanthipeptideNZ_CP097326.1 Lanthipeptides: M5J22_RS16190_lanthipeptideNZ_CP097326.1 Lanthipeptides: M5J22_RS16190_lanthipeptideNZ_CP097784.1 Lanthipeptides: MF619_RS16160_lanthipeptideNZ_CP097784.1 Lanthipeptides: MF619_RS16160_lanthipeptideNZ_CP116014.1 Lanthipeptides: PF996_RS17895_lanthipeptideNZ_CP116014.1 Lanthipeptides: PF996_RS17895_lanthipeptideNZ_JAAKXX010000011.1 Lanthipeptides: G6H00_RS11815_lanthipeptideNZ_JAAKXX010000011.1 Lanthipeptides: G6H00_RS11815_lanthipeptideNZ_JAANHO010000006.1 Lanthipeptides: G9F75_RS12550_lanthipeptideNZ_JAANHO010000006.1 Lanthipeptides: G9F75_RS12550_lanthipeptideNZ_JAIONG010000001.1 Lanthipeptides: K8B35_RS01375_lanthipeptideNZ_JAIONG010000001.1 Lanthipeptides: K8B35_RS01375_lanthipeptideNZ_LMAG01000012.1 Lanthipeptides: ASQ47_RS06825_lanthipeptideNZ_LMAG01000012.1 Lanthipeptides: ASQ47_RS06825_lanthipeptide

Lanthipeptides: BAMY_RS16400_lanthipeptide

1

INTWNTTATSTS-IIISETFGNKGKVCTYTVECVNNC

36

NTWNTT TS I++SE GNKGKVCT T EC C

1

FNTWNTTTTSLGGILVSEVLGNKGKVCTGTKECQGTC

37

52.6%

NZ_CP009288.1and 3 others:

NZ_CP009288.1 Lanthipeptides: PDUR_RS25150_lanthipeptideNZ_CP076607.1 Lanthipeptides: KP014_RS01580_lanthipeptideNZ_CP076607.1 Lanthipeptides: KP014_RS01580_lanthipeptide

Lanthipeptides: PDUR_RS25150_lanthipeptide

5

NTTATSTSIIISETFGNKGKVCTYTVECVNNC

36

NT TSTSI+IS T GN G VCT T EC+ +C

4

NTLTTSTSILISMTLGNNGWVCTATKECMPSC

35

51.3%

NZ_JALGRP010000007.1and 1 other:

NZ_JALGRP010000007.1 Lanthipeptides: MT347_RS12955_lanthipeptide

Lanthipeptides: MT347_RS12955_lanthipeptide

4

WNTTATS-TSIIISETFGNKGKVCTYTVECVNNC

36

W TT TS T +S GN G+VCT TVEC NNC

5

WTTTITSLTCYGVSWVAGNNGQVCTATVECQNNC

38

47.4%

NZ_CP009280.1and 1 other:

NZ_CP009280.1 Lanthipeptides: P40081_RS01820_lanthipeptide

Lanthipeptides: P40081_RS01820_lanthipeptide

5

NTTATSTSIIISETFGNKGKVCTYTVECVNNC

36

NT TSTSI IS GN G VCT++ EC+ +C

4

NTLTTSTSIFISRGLGNDGWVCTWSKECMPSC

35

47.4%

NZ_JAQFWW010000002.1and 1 other:

NZ_JAQFWW010000002.1 Lanthipeptides: PDT38_RS11330_lanthipeptide

Lanthipeptides: PDT38_RS11330_lanthipeptide

3

TWNTTATSTSIIISETF-GNKGKVCTYTVECVNNCR

37

+W T T+ S + + G+KG+VCT TVEC NNCR

2

SWGTLLTTLSCLAASIMIGDKGQVCTGTVECQNNCR

37

47.4%

NZ_LT575476.1and 1 other:

NZ_LT575476.1 Lanthipeptides: BN6628_RS02285_lanthipeptide

Lanthipeptides: BN6628_RS02285_lanthipeptide

3

TWNTTATSTSII-ISETFGNKGKVCTYTVECVNNCR

37

+W T T+ + + S G+KG+VCT TVEC+NNCR

2

SWGTVLTTLACLGASYALGDKGQVCTATVECINNCR

37

44.7%

NC_017299.1and 1 other:

NC_017299.1 Lanthipeptides: H04402_RS03105_lanthipeptide

Lanthipeptides: H04402_RS03105_lanthipeptide

12

SIIISETFGNKGKVCTYTVECVNNC

36

SI +S GN GKVCT+TVEC NNC

8

SITLSVYMGNDGKVCTWTVECQNNC

32

44.7%

NZ_CKMQ01000043.1and 10 others:

NZ_CKMQ01000043.1 Lanthipeptides: AE832_RS11585_lanthipeptideNZ_CKMR01000002.1 Lanthipeptides: AD782_RS11690_lanthipeptideNZ_CKMR01000002.1 Lanthipeptides: AD782_RS11690_lanthipeptideNZ_FIXU01000003.1 Lanthipeptides: A1M11_RS11670_lanthipeptideNZ_FIXU01000003.1 Lanthipeptides: A1M11_RS11670_lanthipeptideNZ_LR216041.1 Lanthipeptides: E0F00_RS05465_lanthipeptideNZ_LR216046.1 Lanthipeptides: E0E82_RS05980_lanthipeptideNZ_LR216046.1 Lanthipeptides: E0E82_RS05980_lanthipeptideNZ_PNGD01000001.1 Lanthipeptides: CJ239_RS00170_lanthipeptideNZ_PNGD01000001.1 Lanthipeptides: CJ239_RS00170_lanthipeptide

Lanthipeptides: AE832_RS11585_lanthipeptide

14

IISETFGNKGKVCTYTVECVNNCR

37

ISE GNKG VCT T+EC NNCR

7

FISEALGNKGAVCTGTIECQNNCR

30

42.1%

NZ_BMRY01000003.1and 24 others:

NZ_BMRY01000003.1 Lanthipeptides: IE140_RS12370_lanthipeptideNZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptideNZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptideNZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptideNZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptideNZ_CP021707.1 Lanthipeptides: CCZ36_RS18205_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptideNZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptideNZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptideNZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptideNZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptideNZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptideNZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptideNZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptideNZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptideNZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptideNZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptideNZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptideNZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptide

Lanthipeptides: IE140_RS12370_lanthipeptide

4

WNTTATSTSII-ISETFGNKGKVCTYTVECVNNCR

37

W T +S S S GN G CT T EC NNC+

4

WGTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

42.1%

NZ_CP116355.1and 1 other:

NZ_CP116355.1 Lanthipeptides: KPP03845_RS17815_lanthipeptide

Lanthipeptides: KPP03845_RS17815_lanthipeptide

4

WNTTATSTSII-ISETFGNKGKVCTYTVECVNNCR

37

W T +S S S GN G CT T EC NNC+

4

WGTVMSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

MIBiG 4.0 matches for F8159_RS30260

34.2%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

15

ISETFGNKGKVCTYTVECVNNC

36

IS GNKG CT TVEC+ +C

6

ISCRLGNKGAYCTLTVECMPSC

27

31.6%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

9

TSTSIIISETFGNKGKVCTYTVECVNNC

36

T+ + +S GN G CT T EC NC

2

TTNTFSLSNALGNNGGWCTLTKECQPNC

29

15.4%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

26

CTYTVECVNNC

36

CT + EC NC

28

CTLSKECQPNC

38

F8159_RS22540

Leader:

MLKEQKLEKITGLIPESELEEHLSG

F8159_RS22545

Leader:

MLKEQKLEKITGLIPESELEEHLSG

Shared core:

ESSGAGTPAIVTAISAVTAVTAQSPCPTSACSKSCNK

Core with dehydrations:

EDhaDhaGAGDhbPAIVDhbAIDhaAVDhbAVDhbAQDhaPCysPDhbDhaACysDhaKDhaCysNK

antiSMASH-DB 4.0 matches for F8159_RS22540

100.0%

NZ_CM000756.1and 17 others:

NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14760_lanthipeptideNZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14765_lanthipeptideNZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14760_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29740_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29735_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29730_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29740_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29735_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29730_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS26900_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS26895_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS26900_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS26895_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS22545_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS22540_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS22545_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS22540_lanthipeptide

Lanthipeptides: BTHUR0011_RS14765_lanthipeptide

1

ESSGAGTPAIVTAISAVTAVTAQSPCPTSACSKSCNK

37

ESSGAGTPAIVTAISAVTAVTAQSPCPTSACSKSCNK

1

ESSGAGTPAIVTAISAVTAVTAQSPCPTSACSKSCNK

37

70.3%

NZ_JAGKQT010000007.1and 3 others:

NZ_JAGKQT010000007.1 Lanthipeptides: J2M30_RS09845_lanthipeptideNZ_LVYL01000010.1 Lanthipeptides: A3863_RS05870_lanthipeptideNZ_LVYL01000010.1 Lanthipeptides: A3863_RS05870_lanthipeptide

Lanthipeptides: J2M30_RS09845_lanthipeptide

6

GTPAIVTAISAVTAVTAQSPCPTSACSKSC

35

GTPAI +AISA+TAVT QSPCPTSACSKSC

1

GTPAIFSAISAITAVTVQSPCPTSACSKSC

30

48.6%

NZ_CP047645.1and 5 others:

NZ_CP047645.1 Lanthipeptides: GSN02_RS17435_lanthipeptideNZ_NJRE01000008.1 Lanthipeptides: CE047_RS18550_lanthipeptideNZ_NJRE01000008.1 Lanthipeptides: CE047_RS18550_lanthipeptideNZ_VIOH01000001.1 Lanthipeptides: FLN47_RS03735_lanthipeptideNZ_VIOH01000001.1 Lanthipeptides: FLN47_RS03735_lanthipeptide

Lanthipeptides: GSN02_RS17435_lanthipeptide

6

GTP--AIVTAISAVTAVTAQSP--CPTSACSKSCNK

37

GTP AI+TA++ T S CPTSAC+ CNK

1

GTPVTAIITALTGTTFTVTLSAASCPTSACTNLCNK

36

with 78 more sequence matches

Only the first 10 are displayed here.

48.6%

NZ_CP086141.1and 1 other:

NZ_CP086141.1 Lanthipeptides: LL065_RS24780_lanthipeptide

Lanthipeptides: LL065_RS24780_lanthipeptide

10

IVTAISAV----TAVTAQSPCPTSACSKSCNK

37

+V+AISA TAV+A TSAC+KSCNK

4

VVSAISATVASATAVSALFTV-TSACTKSCNK

34

48.6%

NZ_JALAUA010000003.1and 1 other:

NZ_JALAUA010000003.1 Lanthipeptides: MOD32_RS04870_lanthipeptide

Lanthipeptides: MOD32_RS04870_lanthipeptide

6

GTP--AIVTAISAVTAVTAQSP--CPTSACSKSCNK

37

GTP AI+TA++ T S CPTSAC+ CNK

1

GTPVTAILTALTGTTFTVTLSAASCPTSACTNLCNK

36

45.9%

NZ_CP102975.1and 1 other:

NZ_FMOE01000002.1 Lanthipeptides: BJT27_RS07810_lanthipeptide

Lanthipeptides: NW953_RS00175_lanthipeptide

7

TPAIVTAISAVTAVTAQSPCPTSACSKSCNK

37

TPA+V V A TAQ CPT ACS C K

2

TPAVVITGILVAASTAQ--CPTLACSSRCGK

30

43.6%

NZ_WHOM01000078.1and 1 other:

NZ_WHOM01000078.1 Lanthipeptides: GCN81_RS29290_lanthipeptide

Lanthipeptides: GCN81_RS29290_lanthipeptide

1

ESSGAG-TPAIVTAISAVTAVTA--QSPCPTSACSKSC

35

ES AG TP I+ A + +A Q CPTS C+K C

2

ESLAAGITPTILPATGVIVGASAALQGGCPTSGCTKRC

39

43.2%

NZ_CM000721.1and 9 others:

NZ_CP015591.1 Lanthipeptides: A7A70_RS27555_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29360_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptideNZ_NUBO01000052.1 Lanthipeptides: CN575_RS29785_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide

Lanthipeptides: BCERE0010_RS29355_lanthipeptide

7

TPAIVTAISAVTAVTAQSPCPTSACSKSC

35

TPA T I A AVTA S CPT+ C+ C

8

TPATPTIIGATIAVTA-SLCPTTKCTSRC

35

43.2%

NZ_CP086141.1and 1 other:

NZ_CP086141.1 Lanthipeptides: LL065_RS24780_lanthipeptide

Lanthipeptides: LL065_RS24780_lanthipeptide

6

GTPAIVTAISAVTAVTAQSPCPTSACSKSCNK

37

T A TA+SA+ VT SAC+KSCNK

6

ATVASATAVSALFTVT-------SACTKSCNK

30

43.2%

NZ_PNGD01000001.1and 1 other:

NZ_PNGD01000001.1 Lanthipeptides: CJ239_RS00165_lanthipeptide

Lanthipeptides: CJ239_RS00165_lanthipeptide

7

TPAIVTAISAVTAVTAQ-----SPCPTSACSKSCNK

37

TP I+ A + VT CPTS C+KSCNK

2

TPTIIAATISFAGVTFTVTLNAGACPTSGCTKSCNK

37

40.5%

NZ_JACSPO010000013.1and 1 other:

NZ_JACSPO010000013.1 Lanthipeptides: H9624_RS14885_lanthipeptide

Lanthipeptides: H9624_RS14885_lanthipeptide

5

AGTPAIVTAISA-VTAVTAQSP--CPTSACSKSC

35

AGT + AI V A++A P CPT AC+ C

1

AGTTTVPCAIGGGVIAISAALPDFCPTGACTTRC

34

40.5%

NZ_BMSZ01000006.1and 4 others:

NZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12790_lanthipeptideNZ_CP021707.1 Lanthipeptides: CCZ36_RS18195_lanthipeptideNZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19730_lanthipeptideNZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19730_lanthipeptide

Lanthipeptides: IE135_RS12790_lanthipeptide

1

ESSGAG-TPAIVTAISAVTAVTA-----QSPCPTSACSKSC

35

+S AG TP IV A + T + Q CPTS C+K C

2

DSLAAGITPTIVPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

40.5%

NZ_BNBJ01000003.1and 9 others:

NZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05295_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS19415_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS19415_lanthipeptideNZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11030_lanthipeptideNZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11030_lanthipeptideNZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32890_lanthipeptideNZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32890_lanthipeptideNZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100135_lanthipeptideNZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100135_lanthipeptide

Lanthipeptides: IE304_RS05295_lanthipeptide

1

ESSGAG-TPAIVTAISAVTAVTA-----QSPCPTSACSKSC

35

ES AG TP I+ A + T + Q CPTS C+K C

2

ESLAAGFTPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

MIBiG 4.0 matches for F8159_RS22540

10.8%

BGC0000581.6 (AAD28494.1):

Lasso peptide: microcin J25

4

GAGTP

8

G GTP

12

GIGTP

16

9.8%

BGC0002120.3 (NQE92413.1):

Lanthipeptide: nocathioamide A

1

ESSGAGTPA

9

ESS PA

31

ESSRPAAPA

39

Lanthipeptide(s) for F8159_RS22550

F8159_RS30260

Leader:

MLDIIKNRKKVKENLELPDTLLEEVEEHSAMGG

Core:

INTWNTTATSTSIIISETFGNKGKVCTYTVECVNNCRG

Core with dehydrations:

INDhbWNDhbDhbADhbDhaDhbDhaIIIDhaEDhbFGNKGKVCysDhbYDhbVECysVNNCysRG

antiSMASH-DB 4.0 matches for F8159_RS30260

100.0%

NZ_CM000756.1and 7 others:

NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS34475_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS30450_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS30450_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS29770_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS29770_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS30260_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS30260_lanthipeptide

Lanthipeptides: BTHUR0011_RS34475_lanthipeptide

1

INTWNTTATSTSIIISETFGNKGKVCTYTVECVNNCRG

38

INTWNTTATSTSIIISETFGNKGKVCTYTVECVNNCRG

1

INTWNTTATSTSIIISETFGNKGKVCTYTVECVNNCRG

38

71.1%

NZ_JAGKQT010000007.1and 3 others:

NZ_JAGKQT010000007.1 Lanthipeptides: J2M30_RS09860_lanthipeptideNZ_LVYL01000010.1 Lanthipeptides: A3863_RS05855_lanthipeptideNZ_LVYL01000010.1 Lanthipeptides: A3863_RS05855_lanthipeptide

Lanthipeptides: J2M30_RS09860_lanthipeptide

2

NTWNTTATSTSIIISETFGNKGKVCTYTVECVNNCR

37

NTWNT +TST I +S GN GKVCTYTVECVNNCR

1

NTWNTISTSTCIAVSHFVGNDGKVCTYTVECVNNCR

36

63.2%

NZ_CP047645.1and 7 others:

NZ_CP047645.1 Lanthipeptides: GSN02_RS17445_lanthipeptideNZ_JALAUA010000003.1 Lanthipeptides: MOD32_RS04860_lanthipeptideNZ_JALAUA010000003.1 Lanthipeptides: MOD32_RS04860_lanthipeptideNZ_NJRE01000008.1 Lanthipeptides: CE047_RS18560_lanthipeptideNZ_NJRE01000008.1 Lanthipeptides: CE047_RS18560_lanthipeptideNZ_VIOH01000001.1 Lanthipeptides: FLN47_RS03725_lanthipeptideNZ_VIOH01000001.1 Lanthipeptides: FLN47_RS03725_lanthipeptide

Lanthipeptides: GSN02_RS17445_lanthipeptide

1

INTWNTTATST-SIIISETFGNKGKVCTYTVECVNNC

36

NTWNTT TS +I++SE FGNKGKVCT T EC C

1

FNTWNTTTTSVGTILVSEVFGNKGKVCTGTKECQGTC

37

with 103 more sequence matches

Only the first 10 are displayed here.

60.5%

NZ_CP017953.1and 27 others:

NZ_CP017953.1 Lanthipeptides: BAMY_RS16400_lanthipeptideNZ_CP021011.1 Lanthipeptides: B6257_RS06480_lanthipeptideNZ_CP021011.1 Lanthipeptides: B6257_RS06480_lanthipeptideNZ_CP033054.1 Lanthipeptides: D9777_RS18850_lanthipeptideNZ_CP033054.1 Lanthipeptides: D9777_RS18850_lanthipeptideNZ_CP041784.1 Lanthipeptides: FOV14_RS15900_lanthipeptideNZ_CP041784.1 Lanthipeptides: FOV14_RS15900_lanthipeptideNZ_CP047268.1 Lanthipeptides: GKS41_RS18615_lanthipeptideNZ_CP047268.1 Lanthipeptides: GKS41_RS18615_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS05705_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS05705_lanthipeptideNZ_CP072563.1 Lanthipeptides: J6600_RS15945_lanthipeptideNZ_CP072563.1 Lanthipeptides: J6600_RS15945_lanthipeptideNZ_CP097326.1 Lanthipeptides: M5J22_RS16190_lanthipeptideNZ_CP097326.1 Lanthipeptides: M5J22_RS16190_lanthipeptideNZ_CP097784.1 Lanthipeptides: MF619_RS16160_lanthipeptideNZ_CP097784.1 Lanthipeptides: MF619_RS16160_lanthipeptideNZ_CP116014.1 Lanthipeptides: PF996_RS17895_lanthipeptideNZ_CP116014.1 Lanthipeptides: PF996_RS17895_lanthipeptideNZ_JAAKXX010000011.1 Lanthipeptides: G6H00_RS11815_lanthipeptideNZ_JAAKXX010000011.1 Lanthipeptides: G6H00_RS11815_lanthipeptideNZ_JAANHO010000006.1 Lanthipeptides: G9F75_RS12550_lanthipeptideNZ_JAANHO010000006.1 Lanthipeptides: G9F75_RS12550_lanthipeptideNZ_JAIONG010000001.1 Lanthipeptides: K8B35_RS01375_lanthipeptideNZ_JAIONG010000001.1 Lanthipeptides: K8B35_RS01375_lanthipeptideNZ_LMAG01000012.1 Lanthipeptides: ASQ47_RS06825_lanthipeptideNZ_LMAG01000012.1 Lanthipeptides: ASQ47_RS06825_lanthipeptide

Lanthipeptides: BAMY_RS16400_lanthipeptide

1

INTWNTTATSTS-IIISETFGNKGKVCTYTVECVNNC

36

NTWNTT TS I++SE GNKGKVCT T EC C

1

FNTWNTTTTSLGGILVSEVLGNKGKVCTGTKECQGTC

37

52.6%

NZ_CP009288.1and 3 others:

NZ_CP009288.1 Lanthipeptides: PDUR_RS25150_lanthipeptideNZ_CP076607.1 Lanthipeptides: KP014_RS01580_lanthipeptideNZ_CP076607.1 Lanthipeptides: KP014_RS01580_lanthipeptide

Lanthipeptides: PDUR_RS25150_lanthipeptide

5

NTTATSTSIIISETFGNKGKVCTYTVECVNNC

36

NT TSTSI+IS T GN G VCT T EC+ +C

4

NTLTTSTSILISMTLGNNGWVCTATKECMPSC

35

51.3%

NZ_JALGRP010000007.1and 1 other:

NZ_JALGRP010000007.1 Lanthipeptides: MT347_RS12955_lanthipeptide

Lanthipeptides: MT347_RS12955_lanthipeptide

4

WNTTATS-TSIIISETFGNKGKVCTYTVECVNNC

36

W TT TS T +S GN G+VCT TVEC NNC

5

WTTTITSLTCYGVSWVAGNNGQVCTATVECQNNC

38

47.4%

NZ_CP009280.1and 1 other:

NZ_CP009280.1 Lanthipeptides: P40081_RS01820_lanthipeptide

Lanthipeptides: P40081_RS01820_lanthipeptide

5

NTTATSTSIIISETFGNKGKVCTYTVECVNNC

36

NT TSTSI IS GN G VCT++ EC+ +C

4

NTLTTSTSIFISRGLGNDGWVCTWSKECMPSC

35

47.4%

NZ_JAQFWW010000002.1and 1 other:

NZ_JAQFWW010000002.1 Lanthipeptides: PDT38_RS11330_lanthipeptide

Lanthipeptides: PDT38_RS11330_lanthipeptide

3

TWNTTATSTSIIISETF-GNKGKVCTYTVECVNNCR

37

+W T T+ S + + G+KG+VCT TVEC NNCR

2

SWGTLLTTLSCLAASIMIGDKGQVCTGTVECQNNCR

37

47.4%

NZ_LT575476.1and 1 other:

NZ_LT575476.1 Lanthipeptides: BN6628_RS02285_lanthipeptide

Lanthipeptides: BN6628_RS02285_lanthipeptide

3

TWNTTATSTSII-ISETFGNKGKVCTYTVECVNNCR

37

+W T T+ + + S G+KG+VCT TVEC+NNCR

2

SWGTVLTTLACLGASYALGDKGQVCTATVECINNCR

37

44.7%

NC_017299.1and 1 other:

NC_017299.1 Lanthipeptides: H04402_RS03105_lanthipeptide

Lanthipeptides: H04402_RS03105_lanthipeptide

12

SIIISETFGNKGKVCTYTVECVNNC

36

SI +S GN GKVCT+TVEC NNC

8

SITLSVYMGNDGKVCTWTVECQNNC

32

44.7%

NZ_CKMQ01000043.1and 10 others:

NZ_CKMQ01000043.1 Lanthipeptides: AE832_RS11585_lanthipeptideNZ_CKMR01000002.1 Lanthipeptides: AD782_RS11690_lanthipeptideNZ_CKMR01000002.1 Lanthipeptides: AD782_RS11690_lanthipeptideNZ_FIXU01000003.1 Lanthipeptides: A1M11_RS11670_lanthipeptideNZ_FIXU01000003.1 Lanthipeptides: A1M11_RS11670_lanthipeptideNZ_LR216041.1 Lanthipeptides: E0F00_RS05465_lanthipeptideNZ_LR216046.1 Lanthipeptides: E0E82_RS05980_lanthipeptideNZ_LR216046.1 Lanthipeptides: E0E82_RS05980_lanthipeptideNZ_PNGD01000001.1 Lanthipeptides: CJ239_RS00170_lanthipeptideNZ_PNGD01000001.1 Lanthipeptides: CJ239_RS00170_lanthipeptide

Lanthipeptides: AE832_RS11585_lanthipeptide

14

IISETFGNKGKVCTYTVECVNNCR

37

ISE GNKG VCT T+EC NNCR

7

FISEALGNKGAVCTGTIECQNNCR

30

42.1%

NZ_BMRY01000003.1and 24 others:

NZ_BMRY01000003.1 Lanthipeptides: IE140_RS12370_lanthipeptideNZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptideNZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptideNZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptideNZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptideNZ_CP021707.1 Lanthipeptides: CCZ36_RS18205_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptideNZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptideNZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptideNZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptideNZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptideNZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptideNZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptideNZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptideNZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptideNZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptideNZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptideNZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptideNZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptide

Lanthipeptides: IE140_RS12370_lanthipeptide

4

WNTTATSTSII-ISETFGNKGKVCTYTVECVNNCR

37

W T +S S S GN G CT T EC NNC+

4

WGTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

42.1%

NZ_CP116355.1and 1 other:

NZ_CP116355.1 Lanthipeptides: KPP03845_RS17815_lanthipeptide

Lanthipeptides: KPP03845_RS17815_lanthipeptide

4

WNTTATSTSII-ISETFGNKGKVCTYTVECVNNCR

37

W T +S S S GN G CT T EC NNC+

4

WGTVMSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

MIBiG 4.0 matches for F8159_RS30260

34.2%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

15

ISETFGNKGKVCTYTVECVNNC

36

IS GNKG CT TVEC+ +C

6

ISCRLGNKGAYCTLTVECMPSC

27

31.6%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

9

TSTSIIISETFGNKGKVCTYTVECVNNC

36

T+ + +S GN G CT T EC NC

2

TTNTFSLSNALGNNGGWCTLTKECQPNC

29

15.4%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

26

CTYTVECVNNC

36

CT + EC NC

28

CTLSKECQPNC

38

F8159_RS22540

Leader:

MLKEQKLEKITGLIPESELEEHLSG

F8159_RS22545

Leader:

MLKEQKLEKITGLIPESELEEHLSG

Shared core:

ESSGAGTPAIVTAISAVTAVTAQSPCPTSACSKSCNK

Core with dehydrations:

EDhaDhaGAGDhbPAIVDhbAIDhaAVDhbAVDhbAQDhaPCysPDhbDhaACysDhaKDhaCysNK

antiSMASH-DB 4.0 matches for F8159_RS22540

100.0%

NZ_CM000756.1and 17 others:

NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14760_lanthipeptideNZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14765_lanthipeptideNZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14760_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29740_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29735_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29730_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29740_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29735_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29730_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS26900_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS26895_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS26900_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS26895_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS22545_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS22540_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS22545_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS22540_lanthipeptide

Lanthipeptides: BTHUR0011_RS14765_lanthipeptide

1

ESSGAGTPAIVTAISAVTAVTAQSPCPTSACSKSCNK

37

ESSGAGTPAIVTAISAVTAVTAQSPCPTSACSKSCNK

1

ESSGAGTPAIVTAISAVTAVTAQSPCPTSACSKSCNK

37

70.3%

NZ_JAGKQT010000007.1and 3 others:

NZ_JAGKQT010000007.1 Lanthipeptides: J2M30_RS09845_lanthipeptideNZ_LVYL01000010.1 Lanthipeptides: A3863_RS05870_lanthipeptideNZ_LVYL01000010.1 Lanthipeptides: A3863_RS05870_lanthipeptide

Lanthipeptides: J2M30_RS09845_lanthipeptide

6

GTPAIVTAISAVTAVTAQSPCPTSACSKSC

35

GTPAI +AISA+TAVT QSPCPTSACSKSC

1

GTPAIFSAISAITAVTVQSPCPTSACSKSC

30

48.6%

NZ_CP047645.1and 5 others:

NZ_CP047645.1 Lanthipeptides: GSN02_RS17435_lanthipeptideNZ_NJRE01000008.1 Lanthipeptides: CE047_RS18550_lanthipeptideNZ_NJRE01000008.1 Lanthipeptides: CE047_RS18550_lanthipeptideNZ_VIOH01000001.1 Lanthipeptides: FLN47_RS03735_lanthipeptideNZ_VIOH01000001.1 Lanthipeptides: FLN47_RS03735_lanthipeptide

Lanthipeptides: GSN02_RS17435_lanthipeptide

6

GTP--AIVTAISAVTAVTAQSP--CPTSACSKSCNK

37

GTP AI+TA++ T S CPTSAC+ CNK

1

GTPVTAIITALTGTTFTVTLSAASCPTSACTNLCNK

36

with 78 more sequence matches

Only the first 10 are displayed here.

48.6%

NZ_CP086141.1and 1 other:

NZ_CP086141.1 Lanthipeptides: LL065_RS24780_lanthipeptide

Lanthipeptides: LL065_RS24780_lanthipeptide

10

IVTAISAV----TAVTAQSPCPTSACSKSCNK

37

+V+AISA TAV+A TSAC+KSCNK

4

VVSAISATVASATAVSALFTV-TSACTKSCNK

34

48.6%

NZ_JALAUA010000003.1and 1 other:

NZ_JALAUA010000003.1 Lanthipeptides: MOD32_RS04870_lanthipeptide

Lanthipeptides: MOD32_RS04870_lanthipeptide

6

GTP--AIVTAISAVTAVTAQSP--CPTSACSKSCNK

37

GTP AI+TA++ T S CPTSAC+ CNK

1

GTPVTAILTALTGTTFTVTLSAASCPTSACTNLCNK

36

45.9%

NZ_CP102975.1and 1 other:

NZ_FMOE01000002.1 Lanthipeptides: BJT27_RS07810_lanthipeptide

Lanthipeptides: NW953_RS00175_lanthipeptide

7

TPAIVTAISAVTAVTAQSPCPTSACSKSCNK

37

TPA+V V A TAQ CPT ACS C K

2

TPAVVITGILVAASTAQ--CPTLACSSRCGK

30

43.6%

NZ_WHOM01000078.1and 1 other:

NZ_WHOM01000078.1 Lanthipeptides: GCN81_RS29290_lanthipeptide

Lanthipeptides: GCN81_RS29290_lanthipeptide

1

ESSGAG-TPAIVTAISAVTAVTA--QSPCPTSACSKSC

35

ES AG TP I+ A + +A Q CPTS C+K C

2

ESLAAGITPTILPATGVIVGASAALQGGCPTSGCTKRC

39

43.2%

NZ_CM000721.1and 9 others:

NZ_CP015591.1 Lanthipeptides: A7A70_RS27555_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29360_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptideNZ_NUBO01000052.1 Lanthipeptides: CN575_RS29785_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide

Lanthipeptides: BCERE0010_RS29355_lanthipeptide

7

TPAIVTAISAVTAVTAQSPCPTSACSKSC

35

TPA T I A AVTA S CPT+ C+ C

8

TPATPTIIGATIAVTA-SLCPTTKCTSRC

35

43.2%

NZ_CP086141.1and 1 other:

NZ_CP086141.1 Lanthipeptides: LL065_RS24780_lanthipeptide

Lanthipeptides: LL065_RS24780_lanthipeptide

6

GTPAIVTAISAVTAVTAQSPCPTSACSKSCNK

37

T A TA+SA+ VT SAC+KSCNK

6

ATVASATAVSALFTVT-------SACTKSCNK

30

43.2%

NZ_PNGD01000001.1and 1 other:

NZ_PNGD01000001.1 Lanthipeptides: CJ239_RS00165_lanthipeptide

Lanthipeptides: CJ239_RS00165_lanthipeptide

7

TPAIVTAISAVTAVTAQ-----SPCPTSACSKSCNK

37

TP I+ A + VT CPTS C+KSCNK

2

TPTIIAATISFAGVTFTVTLNAGACPTSGCTKSCNK

37

40.5%

NZ_JACSPO010000013.1and 1 other:

NZ_JACSPO010000013.1 Lanthipeptides: H9624_RS14885_lanthipeptide

Lanthipeptides: H9624_RS14885_lanthipeptide

5

AGTPAIVTAISA-VTAVTAQSP--CPTSACSKSC

35

AGT + AI V A++A P CPT AC+ C

1

AGTTTVPCAIGGGVIAISAALPDFCPTGACTTRC

34

40.5%

NZ_BMSZ01000006.1and 4 others:

NZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12790_lanthipeptideNZ_CP021707.1 Lanthipeptides: CCZ36_RS18195_lanthipeptideNZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19730_lanthipeptideNZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19730_lanthipeptide

Lanthipeptides: IE135_RS12790_lanthipeptide

1

ESSGAG-TPAIVTAISAVTAVTA-----QSPCPTSACSKSC

35

+S AG TP IV A + T + Q CPTS C+K C

2

DSLAAGITPTIVPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

40.5%

NZ_BNBJ01000003.1and 9 others:

NZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05295_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS19415_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS19415_lanthipeptideNZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11030_lanthipeptideNZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11030_lanthipeptideNZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32890_lanthipeptideNZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32890_lanthipeptideNZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100135_lanthipeptideNZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100135_lanthipeptide

Lanthipeptides: IE304_RS05295_lanthipeptide

1

ESSGAG-TPAIVTAISAVTAVTA-----QSPCPTSACSKSC

35

ES AG TP I+ A + T + Q CPTS C+K C

2

ESLAAGFTPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

MIBiG 4.0 matches for F8159_RS22540

10.8%

BGC0000581.6 (AAD28494.1):

Lasso peptide: microcin J25

4

GAGTP

8

G GTP

12

GIGTP

16

9.8%

BGC0002120.3 (NQE92413.1):

Lanthipeptide: nocathioamide A

1

ESSGAGTPA

9

ESS PA

31

ESSRPAAPA

39

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.07 out of 18.16

Confidence: strong

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.93 out of 30.25

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.76 out of 27.78

Confidence: medium

Additional weak hits (1):

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 20.68 out of 26.12

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

F8159_RS30260 - Class II

Cleavage pHMM score: -3.40

RODEO score: 0

Monoisotopic mass: 3927.0 Da

Molecular weight: 3929.4 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3947.4 Da N = 1; 3965.4 Da N = 2; 3983.4 Da N = 3; 4001.5 Da N = 4; 4019.5 Da N = 5; 4037.5 Da N = 6; 4055.5 Da N = 7; 4073.5 Da N = 8

F8159_RS22540 - Class II

Cleavage pHMM score: -4.80

RODEO score: 0

Monoisotopic mass: 3278.7 Da

Molecular weight: 3280.7 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3298.7 Da N = 1; 3316.7 Da N = 2; 3334.7 Da N = 3; 3352.7 Da N = 4; 3370.8 Da N = 5; 3388.8 Da N = 6; 3406.8 Da N = 7; 3424.8 Da N = 8; 3442.8 Da N = 9

F8159_RS22545 - Class II

Cleavage pHMM score: -4.80

RODEO score: 0

Monoisotopic mass: 3278.7 Da

Molecular weight: 3280.7 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3298.7 Da N = 1; 3316.7 Da N = 2; 3334.7 Da N = 3; 3352.7 Da N = 4; 3370.8 Da N = 5; 3388.8 Da N = 6; 3406.8 Da N = 7; 3424.8 Da N = 8; 3442.8 Da N = 9

F8159_RS30260 - Class II

Cleavage pHMM score: -3.40

RODEO score: 0

Monoisotopic mass: 3927.0 Da

Molecular weight: 3929.4 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3947.4 Da N = 1; 3965.4 Da N = 2; 3983.4 Da N = 3; 4001.5 Da N = 4; 4019.5 Da N = 5; 4037.5 Da N = 6; 4055.5 Da N = 7; 4073.5 Da N = 8

F8159_RS22540 - Class II

Cleavage pHMM score: -4.80

RODEO score: 0

Monoisotopic mass: 3278.7 Da

Molecular weight: 3280.7 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3298.7 Da N = 1; 3316.7 Da N = 2; 3334.7 Da N = 3; 3352.7 Da N = 4; 3370.8 Da N = 5; 3388.8 Da N = 6; 3406.8 Da N = 7; 3424.8 Da N = 8; 3442.8 Da N = 9

F8159_RS22545 - Class II

Cleavage pHMM score: -4.80

RODEO score: 0

Monoisotopic mass: 3278.7 Da

Molecular weight: 3280.7 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3298.7 Da N = 1; 3316.7 Da N = 2; 3334.7 Da N = 3; 3352.7 Da N = 4; 3370.8 Da N = 5; 3388.8 Da N = 6; 3406.8 Da N = 7; 3424.8 Da N = 8; 3442.8 Da N = 9

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
ColR	Phenol-responsive regulator

NZ_WBPC01000040.1 - Region 1 - terpene-precursor

Download region GenBank file

Download region SVG

Location: 693,899 - 714,789 nt. (total: 20,891 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: carboxylase

F8159_RS26505: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Ligases: synthase synthetase

F8159_RS26535: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

F8159_RS26540: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs: SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002283.2	0.49	terpene	sodorifen	Serratia plymuthica
BGC0001361.3	0.49	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.39	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0002219.2	0.39	terpene	(-)-(R)-nephthenol	Stereum hirsutum FP-91666 SS1
BGC0000665.5	0.38	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0002284.3	0.38	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000639.3	0.38	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000642.3	0.37	terpene	carotenoid	Enterobacteriaceae bacterium DC413

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002283.2	0.49	terpene	sodorifen	Serratia plymuthica
BGC0001361.3	0.49	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.39	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0002219.2	0.39	terpene	(-)-(R)-nephthenol	Stereum hirsutum FP-91666 SS1
BGC0000665.5	0.38	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0002284.3	0.38	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000639.3	0.38	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000642.3	0.37	terpene	carotenoid	Enterobacteriaceae bacterium DC413

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

F8159_RS26535: PT_FPPS_like

Domain 1 (32 - 295): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: DMAPP, IPP → FPP

Transcription Factor Binding Sites

Binding sites found:

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 21.28 out of 26.33

Confidence: medium

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 21.32 out of 25.88

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.66 out of 26.06

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.49 out of 27.78

Confidence: medium

Additional weak hits (2):

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 25.40 out of 33.14

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 21.73 out of 30.98

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
ANR	Anaerobic transcriptional regulator
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
MogR	Repressor of flagellar motility genes
PsrA	Oleic acid responsive regulator