LOCUS       NZ_WBPF01000005        23925 bp    DNA     linear   CON 16-NOV-2023
DEFINITION  Bacillus sp. CH140a_4T NODE_5_length_1064852_cov_68.882179, whole
            genome shotgun sequence.
ACCESSION   NZ_WBPF01000005
VERSION     NZ_WBPF01000005.1
KEYWORDS    WGS; RefSeq.
SOURCE      Bacillus sp. CH140a_4T
  ORGANISM  Bacillus sp. CH140a_4T
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
REFERENCE   1  (bases 1 to 1064950)
  AUTHORS   Olmedo-Alvarez,G., Saldana,S. and Barcelo,D.
  TITLE     Bacillus from the desert of Cuatro Cinegas, Coahuila
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 1064950)
  AUTHORS   Olmedo-Alvarez,G., Saldana,S. and Barcelo,D.
  TITLE     Direct Submission
  JOURNAL   Submitted (01-OCT-2019) Ingenieria Genetica, Cinvestav, Libramiento
            Norte Carretera Irapuato Leon Kilometro 9.6, Carr Panamericana
            Irapuato Leon, Irapuato 36824, Mexico
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2013
            Assembly Method                   :: A5-miseq v. 2013
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 50x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 11/16/2023 02:51:40
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,653
            CDSs (total)                      :: 5,545
            Genes (coding)                    :: 5,358
            CDSs (with protein)               :: 5,358
            Genes (RNA)                       :: 108
            rRNAs                             :: 8, 3, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 1 (5S, 23S)
            partial rRNAs                     :: 4, 3, 1 (5S, 16S, 23S)
            tRNAs                             :: 90
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 187
            CDSs (without protein)            :: 187
            Pseudo Genes (ambiguous residues) :: 0 of 187
            Pseudo Genes (frameshifted)       :: 78 of 187
            Pseudo Genes (incomplete)         :: 114 of 187
            Pseudo Genes (internal stop)      :: 56 of 187
            Pseudo Genes (multiple problems)  :: 47 of 187
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 10:06:47
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1019102
            Orig. end                         :: 1043027
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            WBPF01000005.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..23925
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="4"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..23925
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23925
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13925](-)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..13925)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     misc_feature    complement(371..385)
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: weak, score: 18.92"
                     /tool="antismash"
     gene            complement(571..1509)
                     /locus_tag="F8162_RS06250"
                     /old_locus_tag="F8162_06250"
     CDS             complement(571..1509)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000913375.1"
                     /locus_tag="F8162_RS06250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F8162_06250"
                     /product="phosphate/phosphite/phosphonate ABC transporter
                     substrate-binding protein"
                     /protein_id="WP_151634063.1"
                     /transl_table=11
                     /translation="MLKKVFAMSTTVVLAAGLLSGCGTKESSASKTEDTKKGYVPKTLN
                     VQFVPSQNADTLEAKAKPLEKLLSDKLNIPVKVSISTNYNTIVEAMASKQVDVGFLPPT
                     AYVLAHEKKAANVILQAQRFGVDDETGAPTKDLVDFYKSEFVVKKDSNINSVKDLKGKK
                     IGYQDVTSSAGYVWPAAVLLKEGIDPLKDVKPVTLKGHDQSLIALLNGDVDAAVVFQDA
                     RNIVKKDYPNIFDQTKIVKFTEKIPNDTISVRSDLDAEWSKKLQDAFIEIGKNEEGHKI
                     IKEVYSHEGYIKSDDSKFDIVREYGKKVKTQ"
     misc_feature    complement(1657..1674)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: medium, score: 19.4"
                     /tool="antismash"
     gene            1693..3276
                     /locus_tag="F8162_RS06255"
                     /old_locus_tag="F8162_06255"
     CDS             1693..3276
                     /EC_number="3.1.-.-"
                     /EC_number="3.1.3.5"
                     /GO_function="GO:0000166 - nucleotide binding [Evidence
                     IEA]"
                     /GO_function="GO:0008253 - 5'-nucleotidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0042578 - phosphoric ester hydrolase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0009166 - nucleotide catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1283: 2`,3`-cyclic-nucleotide 2`-phosphodiesterase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002199635.1"
                     /locus_tag="F8162_RS06255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F8162_06255"
                     /product="bifunctional metallophosphatase/5'-nucleotidase"
                     /protein_id="WP_151634061.1"
                     /transl_table=11
                     /translation="MNQNQIVTLNILLTSDIHGTVYPIHYQDNSEAEIGLAKISTLIKK
                     ERSQNRNVLLIDNGDFIQGTPFTYHYATYEKDKKNPMSLLANYLRYDAAVIGNHEFNYG
                     MGVLNNAISTANFPYLSANILDKNSKEPYFGKPYIIKHIESNIKIAILGVTTHYIPNWE
                     QPHHIQDLQFEDALETTKKWVSYIHEHEKPDLLVVAYHGGFERDLQTGVPTEVLTGENQ
                     GYAMCHEIEGIDILLTGHQHREIAHTVINGVTILQTGCNGHSIGKITVTFKKTEKKWIK
                     KESYSQLFPVQGITADQHILSLVADYEEKTQNWLDQPIGLIYGDMQISDAMQTRLQDHP
                     FIEFINNIQMDIANVSISCTSLFHNTSPGFPDHVTMRDIVSNYIYPNTLQVIRITGADI
                     KDALELSASYFTLNADGDIIVNPTFIEPKPQHYNYDMWEGISYVLNISKPIGERVESLQ
                     CKGIPLNMDEEYEVVMNNYRASGGGNFFMFQNKPVIKDIPTDMSELIANYILKHKKIEA
                     TVNNNWKVIK"
     misc_feature    complement(1718..1735)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: medium, score: 19.33"
                     /tool="antismash"
     gene            complement(3316..3555)
                     /locus_tag="F8162_RS06260"
                     /old_locus_tag="F8162_06260"
     CDS             complement(3316..3555)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002172959.1"
                     /locus_tag="F8162_RS06260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F8162_06260"
                     /product="DUF896 domain-containing protein"
                     /protein_id="WP_001190582.1"
                     /transl_table=11
                     /translation="MQSHELIERINFLAKKAKAEGLTEEEQRERQSLREQYLKGFRQNM
                     LNELKGIKVVNEEGTDVTPAKLKALKKQDNAKLN"
     misc_feature    complement(3544..3554)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.94"
                     /tool="antismash"
     gene            complement(3601..4257)
                     /locus_tag="F8162_RS06265"
                     /old_locus_tag="F8162_06265"
     CDS             complement(3601..4257)
                     /GO_function="GO:0000150 - DNA strand exchange activity
                     [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016111193.1"
                     /locus_tag="F8162_RS06265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F8162_06265"
                     /product="recombinase family protein"
                     /protein_id="WP_151634059.1"
                     /transl_table=11
                     /translation="MNAIIYARVSTKKEEQETSLLRQKDELLHLAERYQMNVAKVIEEQ
                     ASGYTIERDGILEVLDTIRDEQIDVLLIQDETRLGRGNAKIALMHCLHKEGIKVYTHTH
                     NGELELSDSDSMVLDIIGIVEEYQRKIHNLKIKRGMQRAVEKGFRPENNLKNRHLSIGR
                     EKKEVPIEEIVRLRRNELTFEEIAATLRGFGHNVSKATVHRRYVEYTKQLLDKED"
     misc_feature    complement(4318..4331)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: strong, score: 22.42"
                     /tool="antismash"
     gene            4399..5019
                     /gene="lexA"
                     /locus_tag="F8162_RS06270"
                     /old_locus_tag="F8162_06270"
     CDS             4399..5019
                     /EC_number="3.4.21.88"
                     /GO_function="GO:0004252 - serine-type endopeptidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006282 - regulation of DNA repair
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene="lexA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000413738.1"
                     /locus_tag="F8162_RS06270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F8162_06270"
                     /product="transcriptional repressor LexA"
                     /protein_id="WP_000413737.1"
                     /transl_table=11
                     /translation="MEKLTKRQQDILDFIKLKVQEKGYPPSVREIGQAVGLASSSTVHG
                     HLSRLEEKGYIRRDPTKPRAIEILGDNRMDTETQSVIQVPIVGKVTAGLPITAVESVED
                     HFPLPASIVAGADQVFMLRISGDSMIEAGIFDGDLVVVRQQQSAYNGEIVVALTEDNEA
                     TVKRFYKEKDHFRLQPENSSLEPIILKQVSVIGKVIGVYRDLH"
     gene            complement(5107..5913)
                     /locus_tag="F8162_RS06275"
                     /old_locus_tag="F8162_06275"
     CDS             complement(5107..5913)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016718262.1"
                     /locus_tag="F8162_RS06275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F8162_06275"
                     /product="DUF4097 family beta strand repeat-containing
                     protein"
                     /protein_id="WP_192797604.1"
                     /transl_table=11
                     /translation="MMKKILLVAIACIIIGVIGISQTYEKAVQTAEEGNKEDVIKNEIL
                     KNIEVKLDAGDIVVQKSPDSSFYVKQSGDVRKQEIRIAEDGDTLKIIGEREKGASFDFS
                     FYNFKFQTSAVTIFVPERSYQEIKINSSAGQIEISDVKSDRVSVGTLAGEVDLKHVTAK
                     SVEGSTKAGEVNLKKVIGKVTAKTASGDVYVVDHDPKYDVEASSTAGDVDITLLEKPQD
                     AVITGQSAAGDVMIFNEENKNITIGNGSKKISGKTAAGDVTIETPS"
     gene            complement(5914..6456)
                     /locus_tag="F8162_RS06280"
                     /old_locus_tag="F8162_06280"
     CDS             complement(5914..6456)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000031379.1"
                     /locus_tag="F8162_RS06280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F8162_06280"
                     /product="DUF1700 domain-containing protein"
                     /protein_id="WP_151634055.1"
                     /transl_table=11
                     /translation="MSKEQFLKELSSHLRKLPEEERKDILFDYEEHFQFGKEEGKTESE
                     IIKGLGSPKVIAKDLLALYRFDEMKKDPSTSNITRAVMAAIGLSLFNFIIVLGPLVAII
                     AFIFSFWVGGIASVVTPFFVIGKIFMGTFIWLDIFVSITFVGVGLLLCIIAHYSTKWFK
                     KLCVRYVIWNFKMIKGE"
     gene            complement(6449..6772)
                     /locus_tag="F8162_RS06285"
                     /old_locus_tag="F8162_06285"
     CDS             complement(6449..6772)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016105867.1"
                     /locus_tag="F8162_RS06285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F8162_06285"
                     /product="PadR family transcriptional regulator"
                     /protein_id="WP_001102620.1"
                     /transl_table=11
                     /translation="MNVQFKKGVLELCVLALVKRKDCYGYELVQQISNKFLISEGSVYP
                     LLRRLTKEGYFQTYLKESTEGPPRKYYQLTEQGETQLNLLVTEWRDFAKGVQEIIEGVE
                     WDE"
     gene            complement(7001..8800)
                     /locus_tag="F8162_RS06290"
                     /old_locus_tag="F8162_06290"
     CDS             complement(7001..8800)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016096316.1"
                     /locus_tag="F8162_RS06290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F8162_06290"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_151634053.1"
                     /transl_table=11
                     /translation="MNHIIYFMKKLYSSAGKILYVNLFGMVLISLLEGIGIILLIPMIS
                     MTGIINIGEEITFIAPVSRFLQDFPKTTSLVSILGIYILIVLGQNLLQRNITLRDARTQ
                     QAFVRKLRMETYSMILKAKWSFFLEKRKTNLITILTTELARVSYGVNLILQLLAAILFT
                     FIQVGIAFLLSPQITIFVLVFGLLFLVASRVFIKKARILGGKTSELAKDYLSGITDHFN
                     GIKDIKSNTLEASRLDWLQSLTKKMSNEQMEYMRIRSNSQLFYKVSMAILIAFFLLLSV
                     SIFKAQPAQLLLIVLIFSRLWPRFMTIQSNLEQLAASIPAFKSLWELQGECIEAIEIQD
                     IHQQKNIKPICIEQGIECKDIYFRYNKKEHLYALQNINVQIPINSMTAIVGHSGAGKST
                     LIDVLMGLIQPEKGQVLIDGTPLTSENLLSLRRAISYVPQDPFLFNASIRENLLMIEPN
                     SSEEQIWTALDFAAAAEFVRILPKGLDTLIGDRGVRLSGGERQRLVLARAILRQPSILV
                     LDEATSALDAENEVKIQSAIERLKGTMIIVVIAHRLSTIRNADQVIVLGKGEIVQKGEF
                     NQLAKERKGVFRNLLGSQIEVGS"
     gene            complement(8812..9999)
                     /locus_tag="F8162_RS06295"
                     /old_locus_tag="F8162_06295"
     CDS             complement(8812..9999)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_5"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000409755.1"
                     /locus_tag="F8162_RS06295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F8162_06295"
                     /product="nucleotidyltransferase family protein"
                     /protein_id="WP_151634051.1"
                     /sec_met_domain="NTP_transf_5 (E-value: 3.8e-64, bitscore:
                     212.6, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKDVGLNVEFMSKELKLLFAILKLQDDETVQTYSNELFLDINWE
                     VFLEQTVHHRVYPVIYQKLKQVDEELIPSHIVQTLNRKYKKNTFQMLYLSAEMERINKL
                     CSENEIRMIFLKGPVLSQDLYGDISLRTSCDLDVLIPMQNLEKVEMLLLEQGYVKDDYI
                     QTILSDWKWRHHHITFFDPTRRIKLEIHWRLNPGPGKEPGFEELWKRKRKSTLTSNSVY
                     MLGKEDLFLFLVSHGARHGWSRLRWLVDIKKIVGQDLNWNEIHKLMRKYQVLHLGGQAL
                     ILASQLLGVRLNERMTELVAKKHSKQLAQEALFYFKKMINLHSEPVPEEVLSYHSRHLF
                     SLMSNQQKILFILSQLYPYPIDAKTLPLPKFLHFLYFPLRPFLCLWRKTKKLALL"
     gene            complement(10001..10474)
                     /locus_tag="F8162_RS06300"
                     /old_locus_tag="F8162_06300"
     CDS             complement(10001..10474)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012261438.1"
                     /locus_tag="F8162_RS06300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F8162_06300"
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_076539496.1"
                     /sec_met_domain="PF13471 (E-value: 2.7e-23, bitscore: 78.3,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNIVKRLRVFLSLNMETKLLFLEAFIFLGWARVLKSITFSKVAPS
                     LGDYMNETSVAQIEPHGDTLKKVSEAISIMSRYTFWESQCLVKAIAGMKMLEKRHIEST
                     LYLGTAKDSHGELIAHAWLRSGSFYVSGSEGMEKFTVVGSFAKRLSEDTIKGE"
     gene            complement(10511..10816)
                     /locus_tag="F8162_RS06305"
                     /old_locus_tag="F8162_06305"
     CDS             complement(10511..10816)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thurincin_rSAM_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000990395.1"
                     /locus_tag="F8162_RS06305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F8162_06305"
                     /product="lasso peptide biosynthesis PqqD family chaperone"
                     /protein_id="WP_151634049.1"
                     /sec_met_domain="Thurincin_rSAM_RRE (E-value: 7.2e-08,
                     bitscore: 28.5, seeds: 5, tool: rule-based-clusters)"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 3.3e-26,
                     bitscore: 87.2, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 2.3e-15, bitscore: 52.7,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMYTERISLESQIVQSEENIVSDMDGEKVMLNVQKGKYYNLGQTG
                     GEIWELIKTPIMVTELVSTLLSKYNIERCDCEEQVLSFLDCLFQEGLIQIKDQSNR"
     aSDomain        complement(10532..10774)
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_F8162_RS06305_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="8.40E-28"
                     /identifier="RREFam002.1"
                     /label="F8162_RS06305"
                     /locus_tag="F8162_RS06305"
                     /protein_end="95"
                     /protein_start="14"
                     /score="87.2"
                     /tool="antismash"
                     /translation="QSEENIVSDMDGEKVMLNVQKGKYYNLGQTGGEIWELIKTPIMVT
                     ELVSTLLSKYNIERCDCEEQVLSFLDCLFQEGLIQI"
     aSDomain        complement(10544..10777)
                     /aSDomain="Thurincin_rSAM_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing rSAM protein in a thurincin
                     sactipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_F8162_RS06305_Thurincin_rSAM_RRE.1"
                     /evalue="1.80E-09"
                     /identifier="RREFam019.1"
                     /label="F8162_RS06305"
                     /locus_tag="F8162_RS06305"
                     /protein_end="91"
                     /protein_start="13"
                     /score="28.5"
                     /tool="antismash"
                     /translation="VQSEENIVSDMDGEKVMLNVQKGKYYNLGQTGGEIWELIKTPIMV
                     TELVSTLLSKYNIERCDCEEQVLSFLDCLFQEG"
     gene            complement(10767..11744)
                     /locus_tag="F8162_RS06310"
                     /old_locus_tag="F8162_06310"
     CDS             complement(10767..11744)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002199628.1"
                     /locus_tag="F8162_RS06310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F8162_06310"
                     /product="aldolase"
                     /protein_id="WP_151634047.1"
                     /transl_table=11
                     /translation="MIETTKKNMYKVFGLRVLSEIQLPELPRINEQEETIEVIIRTADL
                     FQKWNEFTNTEQNFVVDKNVVMIRIPDTAIFSIQEGKQIVVSPMKEACEDKIRLYILGT
                     CMGALLIQRGILPLHGSAINIDGKVYAFVGDSGAGKSTLASAFLSKGYKILSDDVIAVT
                     VSSDKTPIVIPSYPQQKLWAESLNAFGMGTASYNPLFERETKYAVPVQSHFFSEPLPLA
                     GVIELTKTEDENVELIRIEGLERLRTLFLHTFRKFLIAQLKLTGWHFTTSTSVINKVDM
                     FHLKRPNNRFTADELVSIILKTIQGGVIDDVYRENFSRVSDCAK"
     gene            complement(11848..11973)
                     /locus_tag="F8162_RS06315"
                     /old_locus_tag="F8162_06315"
     CDS             complement(11848..11973)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002172970.1"
                     /locus_tag="F8162_RS06315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F8162_06315"
                     /product="paeninodin family lasso peptide"
                     /protein_id="WP_000711188.1"
                     /transl_table=11
                     /translation="MKKDWTIPTLEVLDINMTMAGPGLKTPDAVQPDIDEVVHYS"
     gene            complement(11988..13925)
                     /locus_tag="F8162_RS06320"
                     /old_locus_tag="F8162_06320"
     CDS             complement(11988..13925)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GATase_7"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001274520.1"
                     /locus_tag="F8162_RS06320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F8162_06320"
                     /product="lasso peptide isopeptide bond-forming cyclase"
                     /protein_id="WP_151634045.1"
                     /sec_met_domain="GATase_7 (E-value: 9.1e-20, bitscore:
                     66.9, seeds: 307, tool: rule-based-clusters)"
                     /sec_met_domain="Asn_synthase (E-value: 4.4e-23, bitscore:
                     78.5, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAITGIIHFNNEPVSIEHGTRLMSDLQNYPANDIQIWHKENVFL
                     GCHAQWITPESVGERLPFYNYEEQLAITADAIIDNRYELFEKLQVDYADRKNMKDSELI
                     LLSYQKWGESAPKYLVGDFSFMIWDEKKQILFGARDFSGSRTLYFYRSENKFSFCTSIK
                     PLFTLPYVEKKLNEQWLAEFLAIPVNFESVDTSSTVYKTVEQIPPSYSVTVKNGKVKLS
                     RYNTLIAGERLQLKSNEEYEEAFLEVYQNAIRSRLRTHHQVGAHLSGGLDSGSVVSFAA
                     RDLSAANKRLHTYSYVPVKGFVDWTHRSRIADERPFIQSTVQHVGNIKEHYLDFEGRSP
                     LSEIDDWLEILEMPYKFFENTFWLRGIYEEAWLQGVGVLLNGQRGNWTVSWGSAVDYQA
                     MLLKKMNLRRFLQELYSYSKSIGVKKSRVFSVVKKKAFPFLNRISSSKNQIVFPRFINP
                     EFANRMNVFDKLLEHDVDITGTSITDIYEIKKRQFEHLYYWNITGTYGSKLSLRYSLWD
                     RDPTNDLRVVKFCLAVPEEQYVQNGVDRALIRRATKNYLPDKVRLNQLTRGVQGSDGVY
                     RMTHQWSGFIEELEQLSKDPVISEFLDIEVIRTAISKIKEEPHPEYAFDLDFRILMRSL
                     IVYRFMKKII"
     gene            complement(14212..15369)
                     /locus_tag="F8162_RS06325"
                     /old_locus_tag="F8162_06325"
     CDS             complement(14212..15369)
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (39-165). E-value:
                     2.1e-08. Score: 25.6. Matches aSDomain:
                     nrpspksdomains_F8162_RS06325_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000972894.1"
                     /locus_tag="F8162_RS06325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F8162_06325"
                     /product="aminotransferase class I/II-fold pyridoxal
                     phosphate-dependent enzyme"
                     /protein_id="WP_151635388.1"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 3.1e-97,
                     bitscore: 322.1, seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_1_2 (E-value: 3.8e-07, bitscore:
                     25.6, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIKNKEKIYLSSPHMSGNEQKYIKDAFDSNWIAPLGPNVDEFERE
                     LASFVGVKGGAAVSSGTAAIHLALRLLNVQEGDTVFCSSFTFVASANPIVYLGAEPVFI
                     DSEPETWNMSPQALALALHDANKAGKLPKAVILVHLYGQSAKLDEILSLCNHYDVPIIE
                     DAAESLGSTYKGKASGTFGRFGVYSFNGNKIITTSGGGMLVSDDVEALERARFLATQAK
                     DPAPHYEHSKVGYNYRMSNILAGIGRGQLEVLEDRVRARRSVYKRYYEELSLIPGFYFM
                     PELENTRSNRWLTTLTIDEKESGISVGKVLSTLAEENIEARPMWKPLHIQSLFKRKKYY
                     PHSQNEDVSQHLFQSGICLPSGSNMLVEDQKRVIQGVLKAIEWKK"
     aSDomain        complement(14875..15252)
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_F8162_RS06325_Aminotran_1_2.1"
                     /evalue="2.10E-08"
                     /label="F8162_RS06325_Aminotran_1_2.1"
                     /locus_tag="F8162_RS06325"
                     /protein_end="165"
                     /protein_start="39"
                     /score="25.6"
                     /tool="antismash"
                     /translation="DEFERELASFVGVKGGAAVSSGTAAIHLALRLLNVQEGDTVFCSS
                     FTFVASANPIVYLGAEPVFIDSEPETWNMSPQALALALHDANKAGKLPKAVILVHLYGQ
                     SAKLDEILSLCNHYDVPIIEDA"
     gene            complement(15386..16018)
                     /locus_tag="F8162_RS06330"
                     /old_locus_tag="F8162_06330"
     CDS             complement(15386..16018)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002167803.1"
                     /locus_tag="F8162_RS06330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F8162_06330"
                     /product="acetyltransferase"
                     /protein_id="WP_151634043.1"
                     /transl_table=11
                     /translation="MKILIIGCGGHSKVVRDIILSNEGYEIVGYLDDLYTGIIIVNNLY
                     FGAIADAREIINNFNDVKLVIAIGNNKVRREIAKILNQQSSIYATLIHKTAIISSNAYI
                     GNGTVIMPNVVVNADTFIGNHTIINTGSIIEHDNIIDDFVHISPHATLTGSVTIAEGAH
                     IGASATIIPGVQIGKWSIVGAGSVVINDFPSNCTAAGIPAKVINVVN"
     gene            complement(16015..16629)
                     /locus_tag="F8162_RS06335"
                     /old_locus_tag="F8162_06335"
     CDS             complement(16015..16629)
                     /EC_number="2.7.8.-"
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006486 - protein glycosylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Bac_transf"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1146: sugar transferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002199623.1"
                     /locus_tag="F8162_RS06335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F8162_06335"
                     /product="sugar transferase"
                     /protein_id="WP_151634041.1"
                     /sec_met_domain="Bac_transf (E-value: 2.6e-67, bitscore:
                     221.8, seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRIFDVCISLLLLFVCLLPILIVAILVRMKLGAPVLFKQQRPGL
                     HGKPFNVYKFRTMLDKKDSDGELLPDKNRLTTFGAILRKYSLDELPQLINVVRGDLSLV
                     GPRPLLMEYLPLYSSKQAKRHNVKPGITGWAQINGRNLITWEEKFELDVWYVENHSFLL
                     DLKIIVLTILKVFKTEGINHVGHVTMERFTGGEIEIKGEGK"
     gene            complement(16700..16888)
                     /locus_tag="F8162_RS06340"
     CDS             complement(16700..16888)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002137801.1"
                     /locus_tag="F8162_RS06340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_151634039.1"
                     /transl_table=11
                     /translation="MACTCKVIMNGVTDSLQISSDIVWKYSLRLAIFKLFDEIKLMKGD
                     VIKQNKGQLTVVAPCFV"
     gene            complement(16872..19193)
                     /locus_tag="F8162_RS06345"
                     /old_locus_tag="F8162_06340"
     CDS             complement(16872..19193)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016096309.1"
                     /locus_tag="F8162_RS06345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F8162_06340"
                     /product="right-handed parallel beta-helix
                     repeat-containing protein"
                     /protein_id="WP_151634037.1"
                     /transl_table=11
                     /translation="MAKFQVTCVLKSNLPVLSEGEFCFCIDTNELFIGTKKGNVKVSTE
                     NTFERLVSKLKSKTFGSSKSRQSLIGETESANVISGTYFLELERWNVKNDGTDADNTSK
                     GINNALLWASQQGFIEVVLPMGTYLIDENTPIEPQSFMTLNLGGSTLKIRSNGLVKYAI
                     VRYQRNQKFSRVTNGRVQGDKDTHDYTTIPHTHEWGYGIEVGNTTPAEGSNMNYISIDN
                     MEILNCTGDGIAMESTWGQIGEYDFAGTFEVGGISDINGSLIVDGNKIRSNLKIDLHHS
                     SIIKWGYFGLYGDGYGGTGSEIYTELYDVLFYKADNTFVTAAKRVKFFEEVSVPKEADY
                     AKIVLHQGEIPTENGCKITVRIPEFSRNVFIEKCKIHDCRRLGISVSGAKQIYIRDCEI
                     YKMKGTAPQGGIDIEDGYRLNQYINIERNNIYDNQGYNVVVVGGRYINIIQNKLVNNSL
                     VVGENVEKVIVSNNHLREVSCVLSGEVTFTNNQMYATRVTIDQGDKEALIGNCIFHNSA
                     LLMGRDKAYCIQVNQCEFFSDRDLFHSFSQLGSIIGFSAEPQTISDCVIKGGAVEGTSL
                     TGVSPGMKNGWRLNNISFIDTKHPQGIITNLPPGVYTGCKFENSGTISFVTKTPQAEYE
                     FNGCSFSWDAYNLFTVESSQRIAMLKVKNSNFRGGKWGSAFFLWDIGGRIEFNNNAFEY
                     LNSESTDSIINFWNETFTSEFMLIENNIFRSNKSMIGVNANQISSSIALIFKDNIVDTV
                     IIKLRDEHIKKDNYINGVYV"
     misc_feature    19298..19315
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 24.35"
                     /tool="antismash"
     gene            complement(19458..20996)
                     /locus_tag="F8162_RS06350"
                     /old_locus_tag="F8162_06345"
     CDS             complement(19458..20996)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002137803.1"
                     /locus_tag="F8162_RS06350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F8162_06345"
                     /product="oligosaccharide flippase family protein"
                     /protein_id="WP_151634035.1"
                     /sec_met_domain="Polysacc_synt (E-value: 8e-14, bitscore:
                     47.8, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRTMHSIKNISISIFSQMVIVILGFISRKVFLDSLGIEYLGIDGL
                     LINVLSMLVLIEAGIGASIVYNLYKPLAENNQYKIIALVQLYKKIYQILAIIILVISAM
                     IYPVLSYLMKDGESISNVAIIYSIFVVKNVVTYLNAHKRSLIQADQRGYILARVDLLFQ
                     VLTTIFKIFILMYTKNYILYLIIELSIYVIQNVVNGRIVNKNYPYIKTKKKYYIDNDTK
                     EKLIINVKAMFLHNIGGYIVFGTDNILISSFVGLAMVGIYSNYTMIINQLAAVVNPILN
                     GIEASVGNLIATENNDKNYEIFKVTYLVNFWIFSFCTIFLFNLLEPFIGWWLDKKYLLN
                     NMVFVVILINFYLTGMRTAIAIFKNKAGLFVQDKYIPLVEAIINLSLSILLAKMFGLVG
                     IFIGTAISTIATVLWIQPYIVYKNLFKKSVWKYFITYVFYIFLTVVTGFITTSICNYFI
                     EGSTFISLVGKGVICLLVPNVIYILIFYKSTEFQYIRNIFSMMFLQIKKKQNVI"
     gene            complement(21058..21852)
                     /locus_tag="F8162_RS06355"
                     /old_locus_tag="F8162_06350"
     CDS             complement(21058..21852)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016096307.1"
                     /locus_tag="F8162_RS06355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F8162_06350"
                     /product="SP_1767 family glycosyltransferase"
                     /protein_id="WP_225990143.1"
                     /transl_table=11
                     /translation="MKSVDETLDYIIDNNCSVSRFGDGEFALINGENLIFQPYSKELKD
                     RLDEVIKSNKMGHLVCIPNVFEDLNWCTDKSRGYWEKYLELNRSRIYKSIRMNKEYYDA
                     LVTRLYIDHQDKSMVRIRFDKMKDIWNGREIIIIEGAQSRLGVGNDLFKNVKTIDRIIC
                     PSKNAFAKYREILELAKKQKKSKLILIALGPTATVLAYDLSSVGYQTLDIGHIDIEYEW
                     FLKKATEKQPIKNKYVGEVNAGTNVNAISDLNYEGEIIARII"
     gene            complement(21954..22928)
                     /locus_tag="F8162_RS06360"
                     /old_locus_tag="F8162_06355"
     CDS             complement(21954..22928)
                     /EC_number="2.4.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1123: polyprenol-monophosphomannose synthase ppm1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016096306.1"
                     /locus_tag="F8162_RS06360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F8162_06355"
                     /product="glycosyltransferase"
                     /protein_id="WP_151634031.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 1.4e-39,
                     bitscore: 131.7, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNPKISIIVPVYKVEQYIHKCIDSILKQTFKEFELILVNDGSPDS
                     CGEICDRYANQDSRIKVIHKENGGLSSARNAGLDIAQGDYIGFVDSDDWIEADMYELLY
                     GMCVEQDCDIAICSSEIHYNDKTVISSSHPFVIHDRYSAMKAMLEGDLYDEVVWTKLFK
                     RQLLEDIKFPIGMSYEDTAFTYKVIHKCKKVCFIGEPKYHYIKRDNSMMDQAIKEIKID
                     SVLIYDEMCKFMERYYKELYNLVILKLGNCSMVVLNLISVSGRLNEHKSKYYKVIGILN
                     RYFYKTMRLKEYGKSVKFLLLATKLHPLLYKFLINNFAERGHI"
ORIGIN
        1 cttgcgctaa tgctctagca atcgatacac gttgctgttg tcctcctgat aattcatccg
       61 ctcgcgcata tgctttttct aaaatattca ccctttttaa cgattgaaag gcaagctcca
      121 aatcttcttt tggaaataga cctaacgttg tacgcaatgt cgaatgataa ccaacacggc
      181 cagctaatac atttttcaat accgttgatc gctttacaag gttaaagctt tgaaaaatca
      241 taccaatatc tcggcgcatg cgtcgtaagc cttttccttt cgcagcagta atagactccc
      301 cttcaatcat aatttcgcct tctgtaatct catgaagtcg atttaccgat ctgagaagtg
      361 tagactttcc agccccggac agccctacca ttacaacaaa ttcacccttt tgaatgttca
      421 agtttatatt atttaatcct tttgtaccat tcggatacac tttggagaca tttcgaaact
      481 ctatcacata tcttacctac cttctatgta ttcaaaacgg caaactaact gaaaacatat
      541 cattccagtt agctgccatt tccatatgta ttattgcgtt tttactttct ttccatattc
      601 acgaacgata tcaaatttac tatcatcaga tttaatatag ccttcatgtg aatatacttc
      661 ttttatgatt ttgtgacctt cctcattctt tcctatttca atgaaagcgt cctgtaattt
      721 cttactccac tctgcatcta aatcagaacg taccgaaatc gtatcgtttg gaattttctc
      781 tgtaaatttc actattttcg tttgatcgaa tatattcgga taatcttttt tcacaatatt
      841 acgagcatct tggaatacaa cagctgcatc tacatcacca tttaaaagcg caataagcga
      901 ctgatcgtga ccttttaatg taacaggttt cacatccttt agcggatcaa ttccctcttt
      961 taacaatact gccgcaggcc atacatatcc cgctgatgac gttacatctt gataaccaat
     1021 ttttttacct tttaaatctt ttacactgtt aatatttgaa tctttcttaa ctacaaactc
     1081 agatttataa aagtctacta aatcttttgt aggagctcct gtttcatcat ctactccaaa
     1141 acgttgtgct tgtaaaatta cgtttgcagc ctttttctca tgcgctaaca catacgctgt
     1201 tgggggtaaa aagcctacat ctacttgctt agatgccatc gcttctacaa ttgtattgta
     1261 attcgttgaa atactaactt tgaccggaat atttaattta tcacttaata gcttttccaa
     1321 tggtttcgcc ttcgcctcta gcgtatctgc attttgagaa ggaacaaatt gaacatttaa
     1381 agtcttcggt acataacctt ttttcgtatc ttcagtttta cttgcacttg attccttcgt
     1441 tccacagcca cttaataatc ccgccgccag tacaactgtc gtgctcattg caaaaacttt
     1501 tttcaacata ttaatgcctc catttttatt gttataaatt tccttccgta aacatgaaga
     1561 aatatatcac acatttttat taataattgc ttatttacag aatctttaca cattctatac
     1621 attctcatta aaattacctt catatatttg atatgcttaa cttgtagata acaatagaaa
     1681 aggtgaatga tattgaatca aaatcaaatt gtaactttaa acatcttatt aacaagtgat
     1741 atacatggta ctgtttatcc aattcactac caagataact ccgaagctga aattggttta
     1801 gctaaaattt ctactcttat aaaaaaagaa cgttcccaaa atagaaacgt ccttttaatt
     1861 gataacggtg acttcataca aggaacaccc ttcacttatc attacgctac atatgaaaaa
     1921 gataagaaaa atccaatgtc cttattagcg aactatttac ggtatgatgc cgcagtgatt
     1981 gggaatcatg aatttaatta tggaatgggc gtattaaaca atgctatttc tactgcgaac
     2041 ttcccgtatc tatcagcaaa tattttagat aaaaacagca aagaacctta tttcgggaaa
     2101 ccatatataa taaaacatat tgaatcaaat ataaaaattg ctattttagg ggtgacaaca
     2161 cattacattc ctaattggga acaaccccat cacattcaag atttacaatt tgaagatgca
     2221 ttagaaacaa caaaaaagtg ggtttcttac attcacgaac acgagaaacc agatttatta
     2281 gtcgtagcgt atcacggagg atttgaacgc gatctacaaa ccggggtacc gaccgaagtt
     2341 ttaacaggtg aaaaccaagg atatgcaatg tgtcatgaaa ttgaaggaat agatatttta
     2401 ctaacaggcc accaacaccg ggaaatcgct cacaccgtaa taaatggtgt aacaatttta
     2461 cagactggat gcaatggaca ctccattgga aaaataacag taacattcaa aaaaacagaa
     2521 aaaaaatgga taaaaaaaga gagttattca caattatttc ctgtgcaagg aattacggcg
     2581 gaccaacata ttctttcctt agttgccgat tatgaagaga aaacacaaaa ttggctcgat
     2641 caacctattg gactaatcta tggagacatg caaatttcag acgctatgca aactcgtttg
     2701 caagaccatc cttttattga atttataaat aacatacaga tggatatagc taatgtttct
     2761 atttcttgta caagcttatt tcataataca tctccaggtt tccctgatca tgtaacaatg
     2821 cgtgacatcg tttctaatta tatttatcca aatacattac aagtaattag aataactgga
     2881 gcagatataa aagatgccct tgaactctct gcttcttatt tcacattaaa tgcagatgga
     2941 gatattatcg taaaccctac cttcatagaa ccaaagccgc aacactataa ttacgatatg
     3001 tgggaaggga tttcgtacgt attaaacatt tccaaaccta ttggcgagag agtagaatct
     3061 ttacaatgca aaggcattcc tcttaatatg gatgaagaat atgaagtcgt tatgaataat
     3121 tatcgcgcta gcggcggagg aaacttcttt atgttccaaa ataagcccgt aataaaagac
     3181 ataccaacag atatgtctga actgattgct aattatattt tgaaacataa aaagatagaa
     3241 gcaacagtca ataacaactg gaaagttatt aaataacgga tataataaat aaaaaagatg
     3301 ggctttgccc atcttttagt ttaattttgc attatcttgc ttttttaaag cttttaattt
     3361 cgccggtgta acatcagtac cttcttcgtt aacaacttta attcctttaa gttcgtttaa
     3421 catattttga cgaaatcctt ttaaatattg ttcacgtagc gattggcgct cacgttgttc
     3481 ttcttcagtt aaaccttcag cttttgcttt tttcgctaag aagttaatgc gttcaatgag
     3541 ttcgtgactt tgcatctcga atcccccttt tactcaaaac tgattattat catacaatag
     3601 ttagtcctct ttatcaagca attgctttgt atactctaca tatctacgat gtaccgtcgc
     3661 ttttgaaacg ttatgcccaa agccgcgaag cgtcgctgca atttcttcaa aagttaattc
     3721 atttcggcgt aaacgtacaa tttcctcaat tggcacttct tttttctcac gccctatact
     3781 taaatgacga tttttcaaat tattctccgg acgaaatcct ttctctaccg ctctttgcat
     3841 gccacgttta attttcaaat tgtggatctt tctttgatac tcttcaacaa tcccaattat
     3901 atctagcacc atcgaatcag agtcagagag ttctaattct ccattatgcg tatgcgtata
     3961 tacttttatt ccctctttat gtaaacagtg cattaatgca attttcgcat tccctctacc
     4021 aaggcgcgtt tcatcttgta tgagaagtac atcaatttgt tcatcgcgaa ttgtatctag
     4081 cacttctaat atgccatcac gttcaattgt ataaccgcta gcctgctcct caatcacctt
     4141 tgcaacattc atttgatagc gctcagctaa atgcaataat tcatcttttt gacgcaataa
     4201 tgatgtttcc tgttcttctt tttttgtgct cacacgtgca taaataattg cattcatttt
     4261 gaacccttct ttctcactat attttcctta tagtgtatca taaattcgcc tttcgttcga
     4321 acttatgttt gtagaatgtt ttttcgcatg ttatacttat taataagaaa aatgaaagaa
     4381 aacgaggtgt tagaaaacat ggaaaagtta acgaaacgcc agcaagacat tctcgacttt
     4441 attaagctaa aagtacaaga aaaaggatat ccaccttccg tacgcgaaat cggtcaagca
     4501 gtcggcctcg cttctagttc tacagtgcac ggacatttat cacgactaga agaaaaagga
     4561 tatattcgac gcgatccaac aaaaccacga gcaattgaaa ttttaggtga caaccgaatg
     4621 gatacagaaa cacaatctgt tattcaagtt ccaattgtcg gaaaagttac tgctggatta
     4681 ccgattacag cagttgaaag tgtagaagat cacttcccac ttccagctag cattgttgct
     4741 ggagcagacc aagtgtttat gttacgtatt tctggagata gtatgattga agctggtatt
     4801 ttcgatggag atttagttgt tgttcgccaa caacagtctg catataatgg tgaaattgta
     4861 gtcgctttaa cagaagataa cgaagcaact gttaaacgtt tctataagga aaaagaccat
     4921 ttccgtctac aaccggaaaa ctcttcatta gagcctatca ttttaaaaca agtgtcagtt
     4981 atcggcaaag taattggcgt atatcgtgat ttacattaaa aataataaaa gaagataatt
     5041 accttattta tatacggtaa ttatcttctt ttttgtattt tgatagattt tcatacattc
     5101 tattacctac gaaggagttt caatcgtcac atcgccagca gctgttttac cgctaatctt
     5161 tttactacca tttccaatag ttatattttt attttcttca ttaaaaatca ttacgtcgcc
     5221 agcagcgctt tgcccagtta ttactgcatc ttgtggtttt tctaataaag taatatctac
     5281 atccccagca gttgaacttg cctctacatc atacttagga tcatgatcca caacatatac
     5341 atccccgcta gccgttttcg ctgttacttt ccctattacc ttttttaaat tcacctcacc
     5401 agcttttgta gacccctcca cactcttagc tgtgacatgc ttcaaatcta cttctccagc
     5461 aagtgtccca acacttacac gatcactttt cacatcactt atttctattt gtccagctga
     5521 tgaatttatt tttatctcct ggtaagaacg ttctggtaca aatatagtca ctgcagacgt
     5581 ttgaaacttg aaattgtaaa aagaaaaatc aaatgaagca cctttttctc tttccccaat
     5641 aatttttaat gtgtcaccat cttcagcaat acggatttct tgtttacgta catctcctga
     5701 ttgctttaca taaaaagaag aatcgggaga tttttggaca acaatatccc cagcatctaa
     5761 cttaacttct atatttttta gtatttcatt tttaattaca tcttctttat ttccttcttc
     5821 tgcagtttgc actgcttttt catatgtttg tgaaatccca attactccaa taatgataca
     5881 agcgattgct actaacaata tttttttcat catctactcc ccttttatca ttttgaagtt
     5941 ccatattaca taacgtacgc ataacttttt aaaccacttc gtactataat gagcgataat
     6001 acataacaac aaacctactc caacaaacgt tatactaacg aatatatcca accaaataaa
     6061 agtacccata aatatttttc caataacgaa aaatggtgtc actacactag caatcccacc
     6121 gacccaaaag gaaaatataa aagcaataat tgcaactaac gggcctaata caataatgaa
     6181 attaaacaaa ctaagtccaa tcgctgccat aacagccctt gttatattcg aagtagatgg
     6241 gtcctttttc atttcatcaa agcgatacaa agcaagtaaa tctttcgcaa ttactttcgg
     6301 cgagccaaga ccctttatta tttccgattc agtttttcct tcttctttcc caaactgaaa
     6361 atgctcttca taatcaaata aaatatcttt cctctcttct tccggtaact ttctaagatg
     6421 acttgataat tctttaagaa actgttcttt actcatccca ttccacccct tcaataattt
     6481 cttgtacgcc ttttgcaaaa tcacgccact ctgttactaa caaattcagt tgcgtttccc
     6541 cttgctccgt tagttgataa tatttacgag gcggcccctc cgtagattct ttcaaatacg
     6601 tttgaaaata tccttctttc gttaaacgac gtaataaagg atacactgac ccttccgata
     6661 ttaaaaattt atttgagatt tgctgaacaa gttcataacc gtaacaatcc ttacgtttta
     6721 caagtgctaa aacacacagt tctaacacgc cttttttaaa ctgaacgttc aagctcaatc
     6781 cccctttctc attccagtac tattcaatac acggtacctg ttatacccat aatataccac
     6841 ttagtattat tcattgcaag gtactcattt atatttactc cctaaatgta gaaaacgtac
     6901 aaataaaagc ctaaataatg tcctgttata actggccatc actcaggctt ttattcgatt
     6961 cgaactgtat gaatacaaaa attcattcac tctttcccct ctaagaacca acttctattt
     7021 gtgaccctaa taaatttcga aatacacctt ttctctcttt agccaattga ttaaattcac
     7081 ctttttgaac aatttcacct tttcctaaaa caataacttg atctgcattg cggatcgtag
     7141 ataaccgatg cgcaataaca acaataatca tcgttccttt caatctttct attgctgatt
     7201 ggatcttcac ctcattttca gcatctaatg cactcgtagc ttcatctaat actaaaatgg
     7261 acggttgtct taaaatagct cgagctagta caagtcgttg acgttcacca cctgaaagtc
     7321 tcactccacg atctccaatg agagtatcaa gcccttttgg cagtattcgt acaaattcag
     7381 ctgccgccgc aaaatctaat gcagtccaaa tttgttcttc actcgaattc ggctcaatca
     7441 tcaataaatt ttctcttatg cttgcattaa ataaaaaagg atcttgtggc acataactaa
     7501 tagcccgtct caatgacagt aaattttcac ttgtaagagg agttccatct attaatactt
     7561 gacctttctc tggttgaatc aatcccatta aaacatcgat taatgtactc ttcccagctc
     7621 ccgaatgccc cacaatagcc gtcatactat tgattggtat ttgcacatta atattttgaa
     7681 gtgcatacaa atgctccttc ttattatacc gaaaataaat atccttacat tcaataccct
     7741 gttctataca aatcggcttt atattttttt gctggtgtat atcctgtatt tcaatcgctt
     7801 caatacattc cccttgtaat tcccataatg acttaaaagc aggaatgctt gcagcaagct
     7861 gttctaaatt tgactgaatt gtcataaagc gtggccatag tctcgaaaag atgagtacga
     7921 ttaataataa ttgggccggt tgagctttaa atatacttac tgataataat aaaaaaaatg
     7981 caattaatat agccattgaa actttataaa acaattgaga gttcgatctt attctcatat
     8041 actccatttg ctcattactc atcttttttg ttaaagattg taaccagtct aaacgtgatg
     8101 cttccaaagt attactcttt atatctttaa ttccattaaa atgatctgtt ataccagaaa
     8161 gatagtcttt tgccaattct gaggtcttac cgcctagtat tcgtgctttt tttataaaaa
     8221 cacgagaagc taccaagaat aataagccaa agaccaaaac aaatatagtt atttgaggag
     8281 atagtaaaaa cgcaatcccc acctgtataa atgtaaacag aatagcagct aacaattgta
     8341 aaattaaatt aaccccataa cttacacgag ctaattctgt agttaatata gttattagat
     8401 ttgttttcct tttctctaaa aaaaaactcc actttgcttt taaaatcata ctatatgttt
     8461 ccattcttaa ttttcgcaca aaagcttgtt gtgttctcgc atcccttagc gttatatttc
     8521 tttgtagtaa attttgacct aacactatta gtatatatat acctaaaata gaaactagac
     8581 ttgttgtttt aggaaaatcc tgcaaaaatc tagagacagg tgcaataaaa gtaatctcct
     8641 cgcctatatt aattattcca gtcatactta tcataggaat taataaaata atacctatcc
     8701 cttcaagtaa acttattaaa accataccaa ataaattcac atacagtatt tttcccgctg
     8761 aagagtataa tttcttcata aaatatataa tatgattcat cgattttccc cctataacaa
     8821 agcaagcttc tttgttttcc tccaaagaca taaaaacgga cgtaaaggaa aatataaaaa
     8881 atgaagaaat ttaggtaacg gtaatgtttt tgcatcaatt ggataaggat aaagctggct
     8941 caaaataaat aaaatttttt gttgattaga catcagtgaa aataaatgtc tactatgata
     9001 ggaaagtact tcttcaggaa caggttctga atgtaaattt atcattttct tgaaataaaa
     9061 cagtgcttct tgtgctaact gcttcgaatg tttcttagct actaattccg tcatcctttc
     9121 atttagccgt acacctagca attgtgatgc caaaattaat gcttgtcccc ctaaatgaag
     9181 cacttgatat tttctcatta atttatgaat ctcattccag ttaagatctt gaccgacaat
     9241 tttttttatg tctactaacc aacgtaacct ggaccaacca tgtctagcac catgagatac
     9301 aagaaataaa aacaagtctt cctttcctaa catatatacc gaattactcg taagtgtact
     9361 ttttctcttt cgcttccaaa gctcttcaaa cccaggttcc ttacccggtc cgggatttaa
     9421 cctccaatga atttcaagtt tgatccgcct tgttggatcg aaaaatgtta tatggtgatg
     9481 cctccatttc caatcactta atatcgtttg aatataatca tcttttacat acccctgctc
     9541 caaaagtagc atttctactt tttctaaatt ttgcatcgga ataagaacat ccaaatcaca
     9601 ggatgttcgt aaagaaatat ctccatataa atcctgagac agtacaggcc cttttagaaa
     9661 aatcatacga atctcatttt cactacatag tttatttatt cgttccattt cagcacttaa
     9721 ataaagcatt tgaaatgtat tttttttata ttttctattc aaggtttgta caatatgcga
     9781 aggaattagt tcctcatcca cctgtttaag tttttgatat atcaccggat aaactcgatg
     9841 atgcacagtt tgctcaagaa atacctccca attaatatcc aaaaacaatt cattactgta
     9901 agtttgcacg gtttcatcat cttgcaactt caaaattgca aaaagaagtt tcaattcctt
     9961 agacatgaac tctacattaa gaccaacatc tttctccatt ttattctcct ttaatagtgt
    10021 cctcacttag cctttttgca aatgatccaa cgacagtaaa tttctccatt ccttctgatc
    10081 cactaacata aaaagaaccg ctccgtaacc atgcatgcgc aattaattcc ccatgactat
    10141 ccttagcagt tcctaaataa agagtactct caatgtgacg tttttcgagc attttcatcc
    10201 cagctatagc tttaacaagg cactgacttt cccaaaaagt ataacgactc ataatagaaa
    10261 tagcttcaga caccttcttt agtgtatctc cgtgtggctc aatttgagct actgatgttt
    10321 cgttcatata atcccctaaa gaaggtgcaa ctttggaaaa ggtaatactt tttagtacac
    10381 gcgcccatcc taaaaaaata aaagcctcta aaaataaaag ctttgtttcc atgttcagtg
    10441 ataaaaatac tcttaacctt ttcacaatat tcattaatcc cttcctaaca gttctcttga
    10501 cattacgaat ctatctatta gattgatctt ttatttgaat taaaccttct tgaaataaac
    10561 aatctaaaaa ggaaagaact tgctcttcgc aatcacaccg ttcaatgttg tactttgaca
    10621 acaatgtact gacaagttca gtaaccataa ttggagtttt tattagttcc caaatttccc
    10681 cccctgtttg tcccaaatta taatatttcc ctttttgaac atttagcatt actttttccc
    10741 catccatatc actcacaata ttctcttcac tttgcacaat ctgagactct agagaaattc
    10801 tctctgtata catcatctat tactcctcct tgtatagttt ttaatataat tgatacaagt
    10861 tcatctgctg taaacctatt attgggacgt ttcaaatgaa acatatctac cttgtttatc
    10921 acacttgtag aagtagtgaa atgccaacct gttaatttta attgcgcaat taaaaactta
    10981 cgaaacgtgt gcaaaaataa tgtacgcagt cgttcaagtc cttcaattcg aatcaattca
    11041 acattctcat cctctgtttt cgttaactca ataacaccag caagaggtaa tggttcagag
    11101 aaaaaatgag attgtacagg aacagcatac tttgtttctc gttcaaacaa tggattataa
    11161 cttgccgttc ccattccaaa agcattcaaa ctttccgccc ataatttttg ttgcggataa
    11221 gatggaatca caattggagt cttatctgac gaaactgtca cagcaattac atcgtcactc
    11281 aaaattttgt atcctttact taaaaaagcc gatgcaagag ttgatttacc tgctcctgaa
    11341 tcacctacaa aggcataaac tttcccatca atatttattg cactaccatg tagtggcaaa
    11401 atccctcttt gaattagcaa ggcgcccata caagttccaa gtatataaag acgaatctta
    11461 tcttcacaag cttccttcat tggtgaaaca actatttgct ttccttcttg tatagaaaat
    11521 atagctgtat caggaatacg aatcataact acgtttttat caactacaaa attttgttct
    11581 gtgttagtaa attcattcca tttctgaaat aaatcagcag ttcgtattat tacttctatc
    11641 gtttcttctt gttcattaat tctaggtaat tctggcaatt gaatttcact caacaccctt
    11701 agcccaaaaa ctttatacat attttttttt gtagtttcaa tcaactctct cactccaaat
    11761 aattatcagc gttgttttac aaatacccct tatacttcta atgtataagg ggataggaaa
    11821 cataagatct aattactacg cgatgaatta actatagtgc actacttcat caatatctgg
    11881 ttgaacagca tccggcgttt taagtcccgg tccagccatt gtcatattaa tatcaagtac
    11941 ttccagtgta ggaattgtcc aatctttttt catgatgtca cctcccttca aataattttc
    12001 ttcataaatc gatatactat taaactacgc attaaaattc gaaaatctaa atcaaatgca
    12061 tattctggat ggggttcttc tttaatctta gaaatcgcag ttctaataac ctctatatcc
    12121 aagaattctg aaattacagg atccttacta agctgctcaa gctcttcaat aaatccactc
    12181 cattgatgcg tcatacgata aacaccatca gaaccttgaa cacctcgagt aagttgattt
    12241 aatcttactt tatcaggcaa ataatttttg gttgctcttc gaattagtgc ccgatctaca
    12301 ccattttgaa cgtattgttc ttctggaaca gctaaacaaa atttaacaac ccgtaaatca
    12361 ttcgttggat ctcgatccca taaagaatag cgcaaagata atttagatcc gtatgtacca
    12421 gttatattcc aataatataa atgttcaaat tgcctttttt ttatttcata tatatctgtt
    12481 atagaggttc ctgttatatc aacatcatgc tctagaagct tatcgaacac attcattcta
    12541 tttgcaaatt ctggattaat aaatcttggg aaaacgattt ggttttttga tgaagatatt
    12601 cgattcaaaa atggaaatgc cttttttttc actactgaaa atactcgcga tttctttaca
    12661 ccaatacttt tactatacga atataattct tgcaaaaagc gacgcaaatt catctttttc
    12721 aaaagcatag cttgatagtc cacagccgag ccccatgaca ctgtccagtt tcctctctgt
    12781 ccgtttaaga gtactccaac cccctgtaac caggcctcct catagattcc cctaagccaa
    12841 aaagtattct cgaagaattt gtatggcatc tctagaattt caagccaatc atctatttct
    12901 gatagaggac ttcttccttc aaaatctaaa taatgttcct taatatttcc tacatgctgt
    12961 acagttgatt gaataaaagg tcgttcatca gctattctac ttctatgcgt ccaatctaca
    13021 aaccccttta ctgggacata actatatgta tgtagacgtt tatttgctgc acttaaatct
    13081 cgtgcagcaa agctaactac agaacccgaa tcaagtcctc cactcaaatg agcccctact
    13141 tgatgatggg tacgtaaacg tgatcttatc gcattttgat acacttccaa aaacgcttct
    13201 tcatactctt cgtttgattt gagttgaagc ctttctccag cgattagcgt attgtatctc
    13261 gataatttca cctttccatt tttcacagta acagaatagg aaggtggaat ttgttcaaca
    13321 gttttatata ccgttgaaga agtgtctact gattcaaaat tcacaggtat agctaaaaat
    13381 tcagcaagcc actgctcatt caattttttc tcaacatatg gtagagtaaa taacggcttt
    13441 atactagtac aaaaagaaaa tttgttctca ctacgataaa aataaagtgt tcggctccca
    13501 gaaaaatctc tagctccaaa cagtatttgt tttttctcat cccaaatcat aaaagaaaaa
    13561 tcgcccacca aatatttcgg tgctgattct ccccatttct gataagagag taaaatcaac
    13621 tcactatctt tcatgttttt tctatccgca taatctactt gtaatttttc aaacaactca
    13681 taacgattat caataatagc atctgctgta attgccagtt gttcttcata attatagaag
    13741 ggtaatcgtt caccaactga ctctggtgta atccattgtg cgtgacatcc caggaaaacg
    13801 ttttctttat gccatatttg aatatcatta gcagggtaat tttgtaagtc actcattaat
    13861 cgtgtgccat gttcaattga tacaggttca ttattaaagt gaataatgcc agttatagcg
    13921 ctcattttta ccctcctaat atatgaaaag ttactacaaa tactatttat atattaaatt
    13981 cgttaaacat acctctttac cattcttttt aaagaacaaa attacttatt ttattacctt
    14041 ctcaattact ttaattcact tgtggattag ggtttagata tttaaaacct agcactatgt
    14101 tcttttactg tcaatttaaa ctagatattc tcaaagaatt ttcacaaaaa attcattata
    14161 aagaactgat agtcatacgt acacaaatct aattccactt ttacttactt tttatttctt
    14221 ccattctata gcttttaaaa caccttgaat gacccttttt tgatcttcaa ctagcatatt
    14281 agatcctgaa ggcaaacaaa ttccactttg aaataaatgc tgcgacacat cttcattttg
    14341 gctatgcgga taatacttct tccttttaaa gagcgactgt atatgaagcg gcttccacat
    14401 aggacgtgct tcaatattct cttctgctaa agtgctcaac acttttccaa cagagatccc
    14461 ggattccttt tcatcaattg tcagtgtagt aagccaacga ttcgagcgag tattttctaa
    14521 ttcaggcata aaataaaatc ctggtatgag agataactct tcgtaatacc gtttatatac
    14581 agatcttcta gctctcaccc tgtcttctag cacttctaat tgtcctcttc caataccagc
    14641 caatatatta ctcattcgat aattataccc taccttacta tgctcataat gtggtgctgg
    14701 atcctttgct tgtgttgcta aaaacctcgc tctttctaac gcttccacat catcagaaac
    14761 tagcatgcca ccgcccgaag ttgtaataat tttatttcca ttaaatgaat aaaccccaaa
    14821 cctcccgaat gtaccacttg cttttccttt atatgtagaa cctagggatt ctgctgcatc
    14881 ctcaattatg ggaacatcat agtgattaca aagcgaaaga atttcatcta atttcgcact
    14941 ctgaccatat aaatgaacaa gaatgacagc cttaggtaat tttcctgctt tattagcatc
    15001 atgcaacgca agtgctagag cttgtggtga catattccat gtttccggtt ctgagtcaat
    15061 aaataccggt tcagctccca aataaacaat cggattcgca ctcgctacaa aagtgaaact
    15121 tgaacaaaat actgtatcgc cctcttgaac gtttaataat cgtaaagcta aatgaatagc
    15181 cgcggtacct gaactaaccg cagccccgcc tttaactcct acaaaagatg caagttctct
    15241 ttcaaattca tctacatttg gaccaagagg tgcaatccag tttgagtcaa aggcatcttt
    15301 aatatatttt tgttcatttc cgctcatatg cggagaggaa agatagattt tctccttatt
    15361 ttttatcatc attcttcatc tcctctcaat ttactacatt aataactttg gctggaatac
    15421 cagcagcagt acaattagat ggaaaatcat ttatgacaac agaaccagct ccaacaattg
    15481 accacttacc aatttgaaca cctggaatta tagtagctga tgctcctata tgtgccccct
    15541 ctgctatagt gacagaacct gtaagtgtag catgtggtga aatatgaaca aaatcatcaa
    15601 ttatattatc atgttctatt attgagcccg tatttattat agtatggtta ccgatgaaag
    15661 tatcagcatt aacaacgaca tttggcataa ttaccgttcc gtttcctata taagcatttg
    15721 aacttataat agctgtttta tgaattaaag tagcatatat gctactttgt tgatttaata
    15781 tttttgcaat ttctcttctt actttattat ttcctatagc aataacgagc tttacatcat
    15841 taaaattatt gataatttcc cttgcatctg caattgctcc aaaataaaga ttattaacaa
    15901 taattatacc tgtatacaaa tcatctaaat aaccgactat ttcatatcct tcatttgata
    15961 agattatatc cctcacaacc ttactatgcc caccacatcc tattattaaa attttcattt
    16021 tccctccccc tttatttcta tttcccctcc agtaaatcgc tccattgtca catgccctac
    16081 atgattaatt ccctctgttt taaatacttt taatattgta agtacaatta ttttcaaatc
    16141 taataaaaat gagtgattct ccacatacca tacatccaat tcaaattttt cttcccaggt
    16201 aatcaaattc ctaccattta tttgtgccca tcccgtaatt cctggtttta cattatgcct
    16261 tttagcctgt ttactagaat ataagggcaa gtattccatc aataatggtc gtggacctac
    16321 taaacttaaa tcacccctta caacatttat aagttggggt aattcatcta aactatattt
    16381 tctaagaatt gctccaaaag tagtcagtct atttttatct ggaagtaatt ccccatcact
    16441 atctttctta tctagcatag ttctaaactt ataaacatta aacggttttc catgcagtcc
    16501 tggacgctgt tgtttaaaca gtacaggtgc tcctaatttc atcctaacta aaattgcaac
    16561 aataagaata ggaagcaagc atacaaataa taacaataaa gaaatacata catcaaaaat
    16621 tcttttcatg tactatcctc cttacttaat tacgtttcat attcctaaca cgaaagacca
    16681 tttagaactt tatatgtaat taaacaaaac aaggggcaac tacagttagt tgccccttgt
    16741 tttgtttaat tacgtcacct ttcattagtt ttatttcatc aaacagttta aaaatagcta
    16801 gcctaagtga atatttccat acgatatcac tacttatttg caaagaatct gttactccat
    16861 tcattataac tttacacgta cacgccatta atataattat ccttttttat atgttcatcc
    16921 cttaatttga taattactgt gtccacaata ttatctttaa aaattaaagc gattgaggat
    16981 gaaatttgat ttgcattcac gcctatcata cttttgtttg acctaaatat attattttct
    17041 attaacataa actcactcgt aaatgtttca ttccaaaaat taattatact gtctgtcgat
    17101 tccgaattaa gatattcaaa tgcattatta ttaaattcta ttctcccacc aatgtcccat
    17161 aaaaaaaatg ccgatcccca ttttccccct ctaaaattac tatttttcac ttttagcatc
    17221 gctatccttt gagaagactc aacagtaaaa agattataag catcccaact aaatgaacat
    17281 ccattaaatt catattctgc ttgaggagtt tttgtaacaa atgatattgt accgctgttc
    17341 tcaaatttac atcccgtata tactcctggc ggtaaattcg taatgattcc ttgcgggtgt
    17401 ttcgtatcta taaaagaaat attatttaat ctccatccat ttttcatacc aggtgatacg
    17461 cctgtcaaac ttgtaccctc tacagcccct cctttaataa cacaatctga tatagtttgt
    17521 ggttctgctg agaaaccaat tattgaacct aactgtgaaa atgaatgaaa taaatctcga
    17581 tcactaaaaa attcacattg gttgacttga atacaatatg ctttatctct tcccattaac
    17641 aatgcgctat tatgaaaaat acagttacca ataagtgctt ctttatcccc ttgatctatc
    17701 gtgactcgag tagcatacat ttgattattc gtaaaagtta cttctccgct taaaacacaa
    17761 cttacttccc ttaagtgatt attgcttaca attactttct ctacattttc gcctactact
    17821 aatgaattat taactaattt attttgaatg atattaatat atctaccacc gactacaaca
    17881 acgttatatc cctgattatc atatatgtta ttacgttcaa tgtttatata ttgatttaat
    17941 cgatatccat cttcaatatc tattcctccc tgaggcgctg tacctttcat tttgtaaatt
    18001 tcacaatctc taatataaat ttgtttcgct ccagatacgc ttatcccaag ccttctacaa
    18061 tcatgtattt tacatttctc aataaataca tttcgagaaa attccggaat tctaacagtg
    18121 attttacaac cgttttccgt aggtatttca ccttggtgaa gaactatctt cgcataatct
    18181 gcttcttttg gaacactcac ttcttcaaaa aactttactc tcttcgcagc cgttacaaaa
    18241 gtattatcag ccttataaaa taacacatca tataattctg tatatatttc tgaaccagtt
    18301 ccaccatagc catctccata caaaccgaaa tatccccatt ttataatgct actatgatgt
    18361 aaatctattt ttaaattcga tctaatttta ttaccatcta ctattaggga accatttata
    18421 tcactaatcc cccctacttc aaatgtacca gcaaaatcat attctccaat ttgtccccat
    18481 gtactttcca ttgctatacc atcgccagta caatttaaga tttccatatt atctattgaa
    18541 atgtagttca tattactccc ctcagcagga gtcgtatttc ctacttcaat cccatatccc
    18601 cattcatgag tatgaggaat cgttgtataa tcgtgtgtat ctttatcccc ttgaaccctt
    18661 ccattcgtaa cccgagaaaa tttttgattt ctttgatatc gtacgattgc atatttaact
    18721 aatccattac ttcttatttt taaagttgat ccacctaaat ttaaagtcat aaagctttgt
    18781 ggctcaattg gtgtattttc atcaattaaa tatgtcccca taggtaaaac aacttctata
    18841 aatccttgtt gagatgccca taataatgca ttattaatcc ctttagaagt attatccgcg
    18901 tccgttccat catttttaac attccatctc tctaactcaa gaaaatatgt gcccgaaatc
    18961 acattagcag attctgtttc tccaatcagt gattgtctag acttagaact tccaaatgtc
    19021 ttgcttttaa gtttacttac taacctctca aatgtattct ccgttgatac ttttacgttc
    19081 cctttttttg tcccaataaa taactcatta gtatctatac aaaaacaaaa ttctccctcg
    19141 cttaacacag gaagattact tttcaaaaca catgtcacct gaaattttgc cataatttat
    19201 atataacctc caactaagat agaagttgaa ttccgataga aaattcaaac tcacatcagt
    19261 agattgggat aaatatttta tattccgctt acatacgtat ccctttaata gaatactatg
    19321 cattatataa atacgatgtt agggctatta cttcatgttt tctaattaaa atcaagtttc
    19381 gtttcatact aacatgcttc aacaacacta tacttcctta ataattcaaa ttggtataat
    19441 atctatactt tttatagcta aataacgttt tgtttctttt taatttgtaa aaacatcata
    19501 ctaaagatat tccttatata ttgaaattct gtgcttttat aaaaaattaa aatgtatatt
    19561 acatttggta ctaataagca aatcacacct tttccgacta acgaaataaa ggtactacct
    19621 tctatgaaat aattacatat acttgtagta atgaaacctg ttacaacagt taaaaatata
    19681 taaaatacat atgttataaa atacttccaa accgatttct taaaaagatt tttatataca
    19741 atataaggct gaatccaaag tacagtagca attgtactaa tcgccgttcc tatgaatata
    19801 cctaccaatc caaacatttt ggctaataga atagataaac ttaaattgat tatcgcttca
    19861 actaacggaa tatacttatc ttgtacaaat aatcccgctt tatttttaaa aatagctatc
    19921 gcggttcgca tccctgttaa ataaaagttt atgagtatca ctacaaaaac catgttattt
    19981 aataaatact tcttatcaag ccaccaccct ataaatggct ctaacagatt aaataaaaat
    20041 atggtacaaa aagaaaagat ccaaaaattc actaaataag tcactttaaa tatttcataa
    20101 tttttgtcat tattctcagt tgcgattaga tttcctacac ttgcctcaat accatttaat
    20161 ataggattta ctacggctgc taattgattt attatcattg tatagttcga atatatcccg
    20221 accatagcaa gacctacaaa agatgaaatc agtatattat ccgttccaaa tacaatgtat
    20281 cctccaatat tatgcaaaaa cattgccttt acatttataa ttaatttttc tttcgtatca
    20341 ttatctatat aatacttctt ttttgtcttt atataaggat agttcttatt cacaatccta
    20401 ccgtttacga cattttgaat tacatatata ctcaactcta taattaaata caaaatataa
    20461 tttttcgtgt acattaatat aaatattttg aatattgtag ttagcacttg gaataagaga
    20521 tctaccctag ccaatatgta tcctctttga tctgcttgta ttaaagacct cttatgagca
    20581 tttaaatagg taactacatt tttcaccacg aatatcgaat agattatcgc aacattcgat
    20641 atagactccc catctttcat taaataactt aaaacaggat atatcatagc acttattact
    20701 agaataatga ttgctaaaat ctgataaatt tttttatata attgaactag agctataatt
    20761 ttatactgat tattttctgc caatggttta tacaaattgt atactatact tgctcctata
    20821 ccagcctcaa ttaacactaa catggataaa acattaatta acaaaccatc tatccctaaa
    20881 tactctattc ctaaactatc taaaaaaact ttcctagata taaaccctag aataacaata
    20941 accatttgag aaaatatact tattgatata ttcttgattg aatgcatcgt tcgcatgatt
    21001 aatccccttc attaactaga tcatttctaa gtagaaagaa tcctcataac aataaagtta
    21061 tattatcctg gcaataattt caccctcata atttaagtca ctaattgcat tcacattagt
    21121 tccagcattt acttcaccaa catacttatt ttttataggt tgtttttctg tcgctttctt
    21181 caaaaaccat tcatactcta tatcaatatg accaatatct agcgtttgat atccaacaga
    21241 agataaatca tacgctaata ccgtagctgt tgggcctagt gcaattaata ttaatttcga
    21301 ttttttttgc ttttttgcta gctctaaaat ttccctatac ttcgcaaaag catttttcga
    21361 tgggcatatt attctatcaa ttgttttaac atttttaaaa agatcgtttc ctacccctag
    21421 tctactttgt gccccttcaa taatgattat ttctctccca ttccaaatat ctttcatttt
    21481 atcaaagcga attctaacca tactcttatc ttgatgatct atatataacc ttgtaactaa
    21541 ggcatcgtaa tattctttat tcatacgtat actcttataa attctgctac gatttaactc
    21601 taaatatttt tcccaatacc ctcttgattt gtccgtgcac caatttaaat cttcaaaaac
    21661 attcggaata caaactaaat ggcccatctt attactctta ataacttcat ccagtctatc
    21721 ctttaattct tttgaatacg gctgaaaaat taaattttct ccatttataa gagcaaattc
    21781 cccatcacca aatctactta ctgaacaatt attatctata atatagtcaa gtgtttcatc
    21841 aacacttttc actattggcg gcttcctttt catagtaatc accctattat attgaatagt
    21901 cacttcattc ctcgtcccaa tatataaata atataatttc aacaaagact tcttcatata
    21961 tgtccccttt ccgcaaaatt attaattaaa aatttataca ataatggatg tagcttagtc
    22021 gccaataata aaaactttac acttttccca tactctttta aacgcattgt tttataaaaa
    22081 taacgattca atataccaat aaccttataa tatttactct tatgctcatt aagtcttcca
    22141 ctcactgata ttaaatttaa aactaccatc gaacaatttc ctagttttaa tataactagg
    22201 ttatataact ccttataata tcgctccata aatttacaca tttcatcata aattaagact
    22261 gaatcaattt taatctcttt tatagcctga tccatcatac tattatcacg ctttatataa
    22321 tgatatttag gttctcctat gaaacatact tttttacact tatgaataac tttatacgta
    22381 aatgctgtat cttcatatga catacctatc ggaaatttaa tatcctctaa taactgtctt
    22441 ttgaaaagtt tagtccaaac aacttcatca tacaaatccc cttctagcat cgctttcatc
    22501 gcgctatatc tatcatgaat tacaaacgga tggctgcttg aaattaccgt tttatcattg
    22561 taatgaattt cactactaca aatagctata tcacaatcct gttctacgca catgccatac
    22621 aacaattcat acatatccgc ttctatccaa tcgtcactat caacaaatcc tatataatct
    22681 ccctgcgcta tgtctaatcc agcatttctt gcagaagata atccaccatt ttccttatgg
    22741 attactttaa ttcggctatc ttgattcgca tatctatcac aaatctcacc acaactatca
    22801 ggagatccat cattaacaag tatcagctca aactctttga acgtttgttt taatatagaa
    22861 tcaatacatt tatgtatata ctgctcaact ttataaacgg gaacaataat actaatttta
    22921 ggattcataa ttgcaccctt tcctttgcaa ttaacttaga aaactattta ccttttctaa
    22981 tttgttaaat tcctctttta acaaattagt cgttacctct tcgcgcactc tttgttgatc
    23041 caaaagatat ttaatcttgt tatatagact ctcctcatta cattcagcaa caaaaccatt
    23101 atatccatct tttatttgct catttgcgcc tgtaaaatta gtcgtaacaa taggcttttt
    23161 taggcatttt gcctcagcta acgtaagaca atacccttca tgcctagagg tttgaacata
    23221 tatatctgat tgatttacat atggatacgg attaattgcc gatcctaata atagaaaatc
    23281 ctgtttcaaa ttatacttac atattaatgt ctcataatac tctctattct ctccttcccc
    23341 aatacagtac catcgtactt cgtatccctc tttacgtagc attgataaaa ctttaattgc
    23401 aaggtcttga cctttttctt ttgaaagtct acctactgtt actatcttta tacctttata
    23461 tccattgtca aattctactt tttcttttgc catttcattt attaaatctg gaagtacaat
    23521 atttaaaaag acactcgcct tactttctac ttgaggaaac ttctctatta aatgtttttg
    23581 tgcttcttga gaaactacat atatattatc catttgatca tataatttct catataattt
    23641 tgtattaatt ttatgttgaa aaacatcaaa atgtatccaa gaaattttct tttctgaagt
    23701 tactctatta actatataat aatcaattat gtcagtaggc ccttgatatg ctattgcaat
    23761 atcatattta ttcttgttat acggaatgtc tttaaaaatc tctttataga aaacatatct
    23821 atcctttaat ttttttgata ctacataagt aagtaaaaag tttaccccct taatatatct
    23881 tgtattttca aagtactctt taatcgtttt cttgggtggt tgcat
//
