LOCUS       NZ_CP044407            10396 bp    DNA     circular CON 28-JUL-2024
DEFINITION  Actinomadura sp. WMMB 499 strain WMMB499 chromosome, complete
            genome.
ACCESSION   NZ_CP044407
VERSION     NZ_CP044407.1
KEYWORDS    RefSeq.
SOURCE      Actinomadura sp. WMMB 499
  ORGANISM  Actinomadura sp. WMMB 499
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Thermomonosporaceae; Actinomadura.
REFERENCE   1  (bases 1 to 9187113)
  AUTHORS   Braun,D., Bugni,T.S., Chevrette,M.G. and Currie,C.R.
  TITLE     Draft genome of Actinomadura sp. WMMB499
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9187113)
  AUTHORS   Braun,D., Bugni,T.S., Chevrette,M.G. and Currie,C.R.
  TITLE     Direct Submission
  JOURNAL   Submitted (26-SEP-2019) Pharmacy, University of Wisconsin-Madison,
            777 Highland Ave., Madison, WI 53705, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Canu v. Oct-2016
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 300.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_008824145.1-RS_2024_07_28
            Annotation Date                   :: 07/28/2024 05:00:58
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,523
            CDSs (total)                      :: 8,413
            Genes (coding)                    :: 8,251
            CDSs (with protein)               :: 8,251
            Genes (RNA)                       :: 110
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 92
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 162
            CDSs (without protein)            :: 162
            Pseudo Genes (ambiguous residues) :: 0 of 162
            Pseudo Genes (frameshifted)       :: 64 of 162
            Pseudo Genes (incomplete)         :: 108 of 162
            Pseudo Genes (internal stop)      :: 10 of 162
            Pseudo Genes (multiple problems)  :: 19 of 162
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 04:12:41
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 8228913
            Orig. end                         :: 8239309
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP044407.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Genome not circularized.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10396
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ectoine"
                     /region_number="26"
                     /rules="ectoine_synt"
                     /tool="antismash"
     cand_cluster    1..10396
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="ectoine_synt"
                     /kind="single"
                     /product="ectoine"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10396
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5396](-)"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5396)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
     gene            133..786
                     /locus_tag="F7P10_RS37505"
                     /old_locus_tag="F7P10_37505"
     CDS             133..786
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017595585.1"
                     /locus_tag="F7P10_RS37505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_37505"
                     /product="HD domain-containing protein"
                     /protein_id="WP_151016776.1"
                     /transl_table=11
                     /translation="MADFFTEFDAPDTDLTRKAYDHAFAIETAAIAGHSIRTYLFGRAL
                     GEHRGLRPGADYDDEALFLACALHDAGLTEEGDGHARFEVDGADLAASFLREHGLAEDR
                     VRLVWEAIALHTSGGIAHRMRPEIALTHLGAGADVAGFGADALPGGLADRAHAAYPRLG
                     SSPELLHAIVGQIARDPRKAPLGSFPGELARQAGVELPEERFAEAALGAWPGVA"
     gene            complement(846..1736)
                     /gene="ehuA"
                     /locus_tag="F7P10_RS37510"
                     /old_locus_tag="F7P10_37510"
     CDS             complement(846..1736)
                     /GO_component="GO:0009898 - cytoplasmic side of plasma
                     membrane [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0033286 - ATPase-coupled ectoine
                     transmembrane transporter activity [Evidence IEA]"
                     /GO_function="GO:0033288 - ATPase-coupled hydroxyectoine
                     transmembrane transporter activity [Evidence IEA]"
                     /GO_process="GO:0033308 - hydroxyectoine transmembrane
                     transport [Evidence IEA]"
                     /GO_process="GO:0051470 - ectoine transmembrane transport
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ehuA"
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019630634.1"
                     /locus_tag="F7P10_RS37510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_37510"
                     /product="ectoine/hydroxyectoine ABC transporter
                     ATP-binding protein EhuA"
                     /protein_id="WP_151016777.1"
                     /transl_table=11
                     /translation="MPPTDTAPEDPRPADNEGVPTTKEVREGAPGDPAGRPARSGAPGI
                     RFEKVVKRFGSNVVLRELDFSVRPGERVTLIGPSGSGKTTILRLLMTLEKLDEGVIRVG
                     DAPLWHMDKGGKLVAANEKHLHEMRKQIGMVFQQFNLFPNMNVLRNLTEGPVRVLGLSK
                     DEAVERARGLLDMVGLADKEDAHPSRLSGGQQQRVAIARALAMQPKVLLLDEVTSALDP
                     ELVVGVQDLLRDIARESDLTLLCVTHEMHFARDISDRVLMFDQGQIVEEGPPDQIFGEP
                     TEQRTRDFLQAVLAS"
     gene            complement(1723..2376)
                     /gene="ehuD"
                     /locus_tag="F7P10_RS37515"
                     /old_locus_tag="F7P10_37515"
     CDS             complement(1723..2376)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0033286 - ATPase-coupled ectoine
                     transmembrane transporter activity [Evidence IEA]"
                     /GO_function="GO:0033288 - ATPase-coupled hydroxyectoine
                     transmembrane transporter activity [Evidence IEA]"
                     /GO_process="GO:0033308 - hydroxyectoine transmembrane
                     transport [Evidence IEA]"
                     /GO_process="GO:0051470 - ectoine transmembrane transport
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ehuD"
                     /gene_functions="transport (smcogs) SMCOG1096: polar amino
                     acid ABC transporter, inner membrane"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019630633.1"
                     /locus_tag="F7P10_RS37515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_37515"
                     /product="ectoine/hydroxyectoine ABC transporter permease
                     subunit EhuD"
                     /protein_id="WP_151016778.1"
                     /transl_table=11
                     /translation="MQWDTGYAVDVLPALLEGLRVTVLATLIAYAIALVLGLVWTLLRR
                     APNVVVRQTTRWVTEFIRSTPLIPQLFFVYFVFPDWGLTLESLTAGIITLGVHYSTYTA
                     EVYRAGIADIPKGQWEACTALNLPKSRVWLDVILPQAVRRVIPTLGNYLIATFKDTPML
                     LAISVHEVLFVAFDEGAKTLKYLEPLTVAGLIFVLVSVISSIIVRRLERRYATN"
     gene            complement(2376..3089)
                     /gene="ehuC"
                     /locus_tag="F7P10_RS37520"
                     /old_locus_tag="F7P10_37520"
     CDS             complement(2376..3089)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0033286 - ATPase-coupled ectoine
                     transmembrane transporter activity [Evidence IEA]"
                     /GO_function="GO:0033288 - ATPase-coupled hydroxyectoine
                     transmembrane transporter activity [Evidence IEA]"
                     /GO_process="GO:0033308 - hydroxyectoine transmembrane
                     transport [Evidence IEA]"
                     /GO_process="GO:0051470 - ectoine transmembrane transport
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ehuC"
                     /gene_functions="transport (smcogs) SMCOG1096: polar amino
                     acid ABC transporter, inner membrane"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019630632.1"
                     /locus_tag="F7P10_RS37520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_37520"
                     /product="ectoine/hydroxyectoine ABC transporter permease
                     subunit EhuC"
                     /protein_id="WP_151016779.1"
                     /transl_table=11
                     /translation="MSEVLSNDQWLEGALTTIQLTVLGALLALVLALALGLAGTSRHMW
                     VRALNRVYVEFFRGTPALVLLYWFFYALPLVGFRFTPMLAAVLALGLNVGAYGAEVVRG
                     AINAVPKAQYEAAIALNFTPLQRMRHVLLPQGIALMLPPFGNLLIELMKATAIVSLIGL
                     VDLTRVSKNLQSSLGETVTVFAVVLVFYFVIAQVLQLFVRYAERRVDRMLGRRGGHEPS
                     LKSVAAGAPGAGVTG"
     gene            complement(3093..3980)
                     /gene="ehuB"
                     /locus_tag="F7P10_RS37525"
                     /old_locus_tag="F7P10_37525"
     CDS             complement(3093..3980)
                     /GO_component="GO:0030288 - outer membrane-bounded
                     periplasmic space [Evidence IEA]"
                     /GO_function="GO:0033286 - ATPase-coupled ectoine
                     transmembrane transporter activity [Evidence IEA]"
                     /GO_function="GO:0033288 - ATPase-coupled hydroxyectoine
                     transmembrane transporter activity [Evidence IEA]"
                     /GO_function="GO:0033294 - ectoine binding [Evidence IEA]"
                     /GO_function="GO:0033295 - hydroxyectoine binding [Evidence
                     IEA]"
                     /GO_process="GO:0033308 - hydroxyectoine transmembrane
                     transport [Evidence IEA]"
                     /GO_process="GO:0051470 - ectoine transmembrane transport
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ehuB"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1091: glutamine-binding lipoprotein glnH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019630631.1"
                     /locus_tag="F7P10_RS37525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_37525"
                     /product="ectoine/hydroxyectoine ABC transporter
                     substrate-binding protein EhuB"
                     /protein_id="WP_151016780.1"
                     /transl_table=11
                     /translation="MTSSRRDFLRSAVLLSAAVPLAAAGCSTTDPETEASGGGTLQKAK
                     DAGKIKVGFANEAPYGFTDSSGKLTGEAPELARVIFKNLGIDEMEGVQVDFGGLIGGLN
                     AKRFDVIAAGMFVTPERCQSVAFSDPEYVAKSALMVEEGNPMGLTDGKTLASEGAKVGV
                     LTGAVEQGYAESLGVKDVQTFPDQASAYSAIKSGRIDAIWLTRISLADLLSKHEGEGYE
                     VTEAFTPVVDGKEQFGAGAFAFRKADTELLNGFNAELKKLKDGNQLLPILQPFGFTQAE
                     MPGPDDTAAKFCKG"
     misc_feature    3983..3998
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.44"
                     /tool="antismash"
     misc_feature    4069..4086
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 16.45"
                     /tool="antismash"
     gene            complement(4097..5004)
                     /gene="thpD"
                     /locus_tag="F7P10_RS37530"
                     /old_locus_tag="F7P10_37530"
                     /pseudo=""
     CDS             complement(4097..5004)
                     /GO_function="GO:0016706 - 2-oxoglutarate-dependent
                     dioxygenase activity [Evidence IEA]"
                     /codon_start=1
                     /gene="thpD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PhyH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019630630.1"
                     /locus_tag="F7P10_RS37530"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_37530"
                     /product="ectoine hydroxylase"
                     /pseudo=""
                     /sec_met_domain="PhyH (E-value: 4.4e-35, bitscore: 120.8,
                     seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSIIESHPTIDDAYPTRKGAEAALLYRQDPVVYGSPGEGPIDEAT
                     LDSFEANGFLNVDQLIAPEEVEDYRAELRRLSADPQVLADERTVTERGSDEVRSIFEVH
                     KISEVFNALVKDPRVVGRARQILGSDVYVHQSRVNYKPGFTGKDFYWHSDFETWHAEDG
                     MPRMRAVSISIALTENFVHNGALMIMPGSHKTFVAAVGETPAEHYKESLRSQEIGTPDP
                     ASLSILADKHGIELFTGTAGSATMFDCNCMHGSNGNITPFPRSNVFIVFNSVENTCVEP
                     FSAPSPAPRSSARATSPPSAI"
     gene            complement(5001..5396)
                     /locus_tag="F7P10_RS37535"
                     /old_locus_tag="F7P10_37535"
     CDS             complement(5001..5396)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ectoine: ectoine_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018657163.1"
                     /locus_tag="F7P10_RS37535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_37535"
                     /product="ectoine synthase"
                     /protein_id="WP_151016782.1"
                     /sec_met_domain="ectoine_synt (E-value: 9.7e-53, bitscore:
                     176.3, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIVRSLKEIIGTERDVQAPTWHSRRFVLAKEGVGFSMHETVLYAG
                     TETKMWYANHIEAVYCIEGEGELINHENGEKHRIEPGVMYLLNEHEHHTLHAHTDVKTV
                     CVFNPPVTGREVHDENGVYPLLTEEDA"
     misc_feature    5399..5413
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.84"
                     /tool="antismash"
     gene            complement(5494..6756)
                     /gene="ectB"
                     /locus_tag="F7P10_RS37540"
                     /old_locus_tag="F7P10_37540"
     CDS             complement(5494..6756)
                     /EC_number="2.6.1.76"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_function="GO:0047307 - diaminobutyrate-pyruvate
                     transaminase activity [Evidence IEA]"
                     /GO_process="GO:0019491 - ectoine biosynthetic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_3 (21-358). E-value: 3.9e-75.
                     Score: 244.9. Matches aSDomain:
                     nrpspksdomains_F7P10_RS37540_Aminotran_3.1"
                     /codon_start=1
                     /gene="ectB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018657162.1"
                     /locus_tag="F7P10_RS37540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_37540"
                     /product="diaminobutyrate--2-oxoglutarate transaminase"
                     /protein_id="WP_151016783.1"
                     /sec_met_domain="Aminotran_3 (E-value: 7.3e-75, bitscore:
                     251.1, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDTFARMESEVRGYCRGWPTVFTSAQGSHMTDENGRTYLDFFAGA
                     GTLNYGHNNPQLKRRLLDYLASDSIVHSLDMYTSAKREFLERFNEFVLSPRGLDYKVQF
                     PGPAGNNSVEAALKLARKYTGRETVVSFTNAFHGMTLGALAVTGNSMKRTGAGVPLGHG
                     VAMPYDNYLDGRTPDFLLFDTMLDDSGSGLDKPAAVIVETVQGEGGINVATAEWLRGLQ
                     DLCRRHEILLIVDDVQMGCGRTGAFFSFEEAGITPDIVCLSKSLSGYGLPFAVTLMRRE
                     LDVWEPGEHNGTFRGFNPAFVTAVGALEDYWAGEGMEKQTLAKGQQVQTALEEIALSHA
                     GAVDSVRGRGLAWGLVMKDPETAPKVCGEAFKRGLLMETSGPEGEVVKLLPPLTVTETE
                     LGRGLEIIADSVEAVRSTVTV"
     aSDomain        complement(5683..6693)
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_F7P10_RS37540_Aminotran_3.1"
                     /evalue="3.90E-75"
                     /label="F7P10_RS37540_Aminotran_3.1"
                     /locus_tag="F7P10_RS37540"
                     /protein_end="358"
                     /protein_start="21"
                     /score="244.9"
                     /tool="antismash"
                     /translation="FTSAQGSHMTDENGRTYLDFFAGAGTLNYGHNNPQLKRRLLDYLA
                     SDSIVHSLDMYTSAKREFLERFNEFVLSPRGLDYKVQFPGPAGNNSVEAALKLARKYTG
                     RETVVSFTNAFHGMTLGALAVTGNSMKRTGAGVPLGHGVAMPYDNYLDGRTPDFLLFDT
                     MLDDSGSGLDKPAAVIVETVQGEGGINVATAEWLRGLQDLCRRHEILLIVDDVQMGCGR
                     TGAFFSFEEAGITPDIVCLSKSLSGYGLPFAVTLMRRELDVWEPGEHNGTFRGFNPAFV
                     TAVGALEDYWAGEGMEKQTLAKGQQVQTALEEIALSHAGAVDSVRGRGLAWGLVMK"
     gene            complement(6818..7366)
                     /gene="ectA"
                     /locus_tag="F7P10_RS37545"
                     /old_locus_tag="F7P10_37545"
     CDS             complement(6818..7366)
                     /EC_number="2.3.1.178"
                     /GO_function="GO:0033816 - diaminobutyrate
                     acetyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0019491 - ectoine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ectA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018657161.1"
                     /locus_tag="F7P10_RS37545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_37545"
                     /product="diaminobutyrate acetyltransferase"
                     /protein_id="WP_151016784.1"
                     /transl_table=11
                     /translation="MAAQSLETTTRRPDANETNEDVRLQEPSLTDGPEMWRLARDSKVL
                     DVNSPYSYTLWCRDFADTSVVARDAGVPCGFITGYTRPSSADTFFVWQVAVDHDHRGQG
                     LARRMLDELADRLAARGHRYLEATVTPDNAASTAMFESFARARGCELVRSPLFGSEHFP
                     EGGHEPEVLFRIGPIKATD"
     misc_feature    7629..7644
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.4"
                     /tool="antismash"
     misc_feature    complement(7691..7705)
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: weak, score: 24.27"
                     /tool="antismash"
     gene            complement(8049..9017)
                     /gene="pip"
                     /locus_tag="F7P10_RS37550"
                     /old_locus_tag="F7P10_37550"
     CDS             complement(8049..9017)
                     /EC_number="3.4.11.5"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0004177 - aminopeptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0030163 - protein catabolic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (39-301). E-value:
                     1.4e-37. Score: 121.6. Matches aSDomain:
                     nrpspksdomains_F7P10_RS37550_Abhydrolase_1.1"
                     /codon_start=1
                     /gene="pip"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012853167.1"
                     /locus_tag="F7P10_RS37550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_37550"
                     /product="prolyl aminopeptidase"
                     /protein_id="WP_151016785.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 6.9e-10, bitscore:
                     38.8, seeds: 455, tool: rule-based-clusters)"
                     /sec_met_domain="PF00561 (E-value: 5.7e-32, bitscore:
                     110.3, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELRTLYPPIEPYDSGLLDVGDGNRVYWEVCGNPEGKPAVMLHGG
                     PGGGCSPAHRRQFDPEAYRIVLFDQRNCGRSEPHAKDPAVSLEANTTWHLVADMERLRE
                     HLGIDRWLVFGGSWGSALALSYAQTHPERVTELVLRGIFTLRPFELYWFYQEGASLIFP
                     DLWERYVEPIPEDEREDLVSAFHERLNSPDRDVRVAAARAWSTWEGSTLTLRPDEELAS
                     GFGEPDYAVAFARIENHYFVNEGFFEEDQLIRDVGKIRHIPAVIVQGRYDMCTPVATAW
                     DLHRAWPEADLHIVDDAGHAYSEPGILHHLIEATDRFARTR"
     aSDomain        complement(8115..8900)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_F7P10_RS37550_Abhydrolase_1.1"
                     /evalue="1.40E-37"
                     /label="F7P10_RS37550_Abhydrolase_1.1"
                     /locus_tag="F7P10_RS37550"
                     /protein_end="301"
                     /protein_start="39"
                     /score="121.6"
                     /tool="antismash"
                     /translation="VMLHGGPGGGCSPAHRRQFDPEAYRIVLFDQRNCGRSEPHAKDPA
                     VSLEANTTWHLVADMERLREHLGIDRWLVFGGSWGSALALSYAQTHPERVTELVLRGIF
                     TLRPFELYWFYQEGASLIFPDLWERYVEPIPEDEREDLVSAFHERLNSPDRDVRVAAAR
                     AWSTWEGSTLTLRPDEELASGFGEPDYAVAFARIENHYFVNEGFFEEDQLIRDVGKIRH
                     IPAVIVQGRYDMCTPVATAWDLHRAWPEADLHIVDDAGHA"
ORIGIN
        1 cggcgacgat gtgcggtccc gcgggggtca tggccagaac gtagcgcaca tcggcagcac
       61 ggccactgtc gggggacggg cgctccggcg gacgatcggt gacgttcacc ggcacccgag
      121 cgaggagacc acgtggccga cttcttcacc gagttcgacg cacccgacac cgacctgacc
      181 cgcaaggcgt acgaccacgc cttcgcgatc gagaccgcgg ccatcgccgg gcacagcatc
      241 cgcacctacc tgttcgggcg cgccctcggg gaacaccggg ggctgcgccc cggcgccgac
      301 tacgacgacg aggcgctgtt cctcgcgtgc gcgctgcacg acgccgggct gaccgaggaa
      361 ggggacgggc acgcgcgctt cgaggtggac ggcgccgacc tcgccgcgtc gttcctgcgg
      421 gagcacgggc tcgcggagga ccgcgtccgc ctcgtgtggg aggcgatcgc cctgcacacc
      481 agcgggggca tcgcgcaccg gatgcgtccc gagatcgcgc tcacccacct cggcgccggc
      541 gccgacgtcg ccgggttcgg ggcggacgcc ctccccggcg ggctcgccga ccgggcgcat
      601 gcggcgtacc cccggctggg atcgagcccg gagctcctgc acgcgatcgt cggccagatc
      661 gcccgcgacc cgcgcaaggc gccgctgggc tcgttccccg gcgaactcgc ccggcaggcc
      721 ggcgtcgagc ttcccgagga gcgattcgcc gaggcggccc tgggggcgtg gccgggagtc
      781 gcctgacggc ccgaacgcgc gtgcgcccgc gtcccggagc gggacgcggg cgcacgcggc
      841 gggagtcagg aggccaggac ggcctgcagg aagtcccgcg tgcgctgctc ggtgggctcg
      901 ccgaagatct ggtccggcgg gccctcctcg acgatctggc cctggtcgaa catcaggacc
      961 cggtccgaga tgtccctggc gaagtgcatc tcgtgcgtga cgcacagcaa cgtcaggtcg
     1021 ctctcgcggg cgatgtcgcg cagcaggtcc tggacgccga cgaccagctc ggggtcgagc
     1081 gccgaggtga cctcgtccag cagcagcacc ttgggctgca tggccagtgc ccgcgcgatc
     1141 gccacccgct gctgctggcc gcccgacagc ctgctcgggt gggcgtcctc cttgtcggcc
     1201 agcccgacca tgtccagcag gccgcgggcg cgctcgacgg cctcgtcctt ggacagcccc
     1261 agcacgcgca ccgggccctc ggtgaggttg cggagcacgt tcatgttggg gaacaggttg
     1321 aactgctgga acaccatgcc gatctgcttg cgcatctcgt gcaggtgctt ctcgttggcc
     1381 gcgacgagct tgccgccctt gtccatgtgc cacagggggg cgtcgccgac ccggatgacg
     1441 ccctcgtcga gcttctcgag cgtcatcagc aaccgcagga tcgtggtctt gcccgacccg
     1501 gacggcccga tgagcgtcac ccgctcgccg ggacgcacgc tgaagtcgag ctcgcggagc
     1561 acgacgttgc tgccgaaccg cttgaccacc ttctcgaagc ggatgcccgg agcgccgctc
     1621 cgcgccggcc gcccggccgg gtcgcccggg gcgccctcgc ggacctcctt cgtggtcggg
     1681 acgccctcgt tgtccgcggg cctcgggtct tcgggtgcgg tgtcagttgg tggcataacg
     1741 cctctccagg cggcggacga tgatcgagga gatcacgctg accaggacga agatcaggcc
     1801 cgcgacggtc agcggctcca ggtacttcag ggtcttggcg ccctcgtcga acgcgacgaa
     1861 gagcacctcg tggacgctga tcgccagcag catcggcgtg tccttgaagg tcgcgatcag
     1921 gtagttcccg agggtcggga tgacgcgccg gaccgcctgc ggcaggatca cgtccagcca
     1981 gacccgcgac ttcggcaggt tgagcgcggt gcacgcctcc cactgcccct tcgggatgtc
     2041 agcgatgccc gcgcggtaca cctccgccgt gtaggtggag tagtggacgc cgagcgtgat
     2101 gatcccggcg gtgagcgact ccagcgtcag gccccagtcg gggaagacga agtagacgaa
     2161 gaacagctgc gggatcagcg gcgtggaccg gatgaactcg gtcacccacc gcgtcgtctg
     2221 ccggacgacc acgttcgggg cccgccgcag cagcgtccac accagcccga ggaccagggc
     2281 gatcgcgtag gcgatcagcg tcgcgaggac ggtgacgcgc agcccctcga gcagggccgg
     2341 gaggacgtcg acggcgtacc cggtgtccca ctgcatcagc cggtcacccc cgctccggga
     2401 gcgcccgcgg cgacggactt cagggacggc tcgtggccgc cgcggcggcc gagcatccgg
     2461 tcgacgcggc gctccgcgta gcggacgaac agctgcagga cctgcgcgat cacgaagtag
     2521 aacaccagga cgacggcgaa gaccgtgacg gtctcaccca ggctgctctg caggttcttc
     2581 gacacccgtg tcaggtcgac caggccgatc agggacacga tggccgtggc cttcatcagc
     2641 tcgatgagca ggttgccgaa cggcggcagc atgagcgcga tcccctgcgg aagcaggacg
     2701 tgccgcatcc gctggagggg cgtgaagttc agcgcgatcg ccgcctcgta ctgggccttg
     2761 ggcacggcgt tgatcgcacc gcgcaccacc tcggccccgt acgcgccgac gttcaggccg
     2821 agggcgagca ccgccgcgag catcggagtg aaccggaagc cgacgagggg aagcgcgtag
     2881 aagaaccagt acagcagcac cagcgccggg gttccgcgga agaactccac gtagacgcgg
     2941 ttgagggcgc gcacccacat gtggcgcgag gtgcccgcca ggccgagggc cagggcgagc
     3001 accagcgcca gcagtgcacc caggacggtc agctggatcg tcgtcagcgc gccctctagc
     3061 cactggtcgt tgctgaggac ctcggacacg gatcagccct tgcagaactt ggcggccgtg
     3121 tcgtccgggc cgggcatctc cgcctgggtg aacccgaacg gctggaggat cggcagcagc
     3181 tggttcccgt ccttcagctt cttcagctcc gcgttgaagc cgttcagcag ctccgtgtcg
     3241 gccttgcgga acgcgaaggc gcccgcgccg aactgctcct tgccgtcgac gacgggggtg
     3301 aacgcctcgg tgacctcgta gccctcgccc tcgtgcttgg acagcaggtc ggcgagcgag
     3361 atgcgggtga gccagatggc gtcgatccgg ccggacttga tggcggagta ggcgctcgcc
     3421 tggtccggga acgtctggac gtccttgacg ccgaggctct cggcgtagcc ctgctcgacg
     3481 gcgccggtca gcacgccgac cttggcgccc tcggacgcga gggtcttgcc gtcggtgagc
     3541 cccatcgggt tgccttcctc gaccatgagc gcgctcttgg cgacgtactc ggggtccgag
     3601 aaggccaccg actggcagcg ctcgggcgtg acgaacatgc cggccgcgat gacgtcgaag
     3661 cgcttggcgt tcagcccgcc gatcaggccg ccgaagtcga cctggacgcc ctccatctcg
     3721 tcgatgccga ggttcttgaa gatgacgcgg gccagctcgg gggcctcacc ggtcagcttc
     3781 ccggagctgt cggtgaagcc gtacggggcc tcgttggcga agccgacctt gatcttgccg
     3841 gcgtccttcg ccttctggag cgtgccgccg ccgctggcct cggtctccgg gtccgtcgtg
     3901 gagcaacccg ccgcggcgag gggcaccgcg gcggacagca gaacggcgga gcggaggaaa
     3961 tcgcgtcgtg aggaagtcat cgtcgaactc ctgctcgggg ggtttcttgg ggggcgaacg
     4021 tcgcgcccgc ggagacgata tgcctccgcg ggcgcgacga ccttggtccg gttattgaat
     4081 tgttacgcca tcggtgtcaa tcgcggacgg gggtgaagtc gcgcgcgccg atgaacgtgg
     4141 ggcgggggag ggcgccgaga aaggctcgac gcacgtgttc tccacgctgt tgaacacgat
     4201 gaacacgttg gaccgcggga acggcgtgat gttcccgttg gagccgtgca tgcagttgca
     4261 gtcgaacatg gtcgccgagc cggcggtgcc ggtgaacagc tcgatgccgt gcttgtcggc
     4321 gaggatggac aggctggccg ggtcgggggt cccgatctcc tggctgcgca gcgactcctt
     4381 gtagtgctcg gcgggggtct ccccgacggc cgccacgaac gtcttgtgcg agcccggcat
     4441 aatcatgagg gcgccattgt gcacgaagtt ctcggtcagc gcgatggaga tgctcaccgc
     4501 gcgcatccga ggcatgccgt cctccgcgtg ccaggtctcg aagtcagagt gccagtagaa
     4561 gtccttgccg gtgaagcccg gcttgtagtt gacccggctc tggtgcacgt aaacgtccga
     4621 acccaggatt tgccgggccc ggccgacgac gcgcgggtcc ttgacgagcg cgttgaagac
     4681 ttcgctgatc ttgtggactt cgaagatgga ccggacctcg tccgacccgc gctcggtgac
     4741 cgtgcgctcg tcggccagga cctgcgggtc ggcggacagc cggcgcagct cggcgcggta
     4801 gtcctcgacc tcctccggcg cgatcagctg gtcgacgttc aggaagccgt tggcctcgaa
     4861 ggagtcgagg gtcgcctcat cgatgggacc ctcgccggga ctgccgtaga ccaccgggtc
     4921 ctgtcggtac aggagcgcgg cctcggcgcc cttgcgcgtg ggataggcgt cgtcgatggt
     4981 cgggtgcgac tcgatgatgc tcatgcgtcc tcctctgtga gcagcgggta gaccccgttc
     5041 tcgtcatgca cctcccgccc ggtcacgggc gggttgaaca cgcagaccgt cttgacatcg
     5101 gtgtgtgcat gcagagtgtg gtgttcgtgc tcgttgagca ggtacatgac gccgggctcg
     5161 atacggtgct tctcaccgtt ctcgtgattg atcagctccc cttcgccctc gatgcagtaa
     5221 acggcctcga tgtggttcgc gtaccacatc ttggtctccg tcccggcgta cagcacggtc
     5281 tcgtgcatcg agaagccgac gccctccttg gccagcacga accggcggct gtgccacgtg
     5341 ggcgcctgaa catcgcgctc ggtgccgatg atctccttca gggaacgaac gatcattgat
     5401 ctcctctttc gatcggcggg ggcggccggt gacggcctcg ggggcgggcc cgatcgcgaa
     5461 gggcccgccc ggtccccgtg cgggacggtc ggttcagacc gtcacggtcg agcggacggc
     5521 ctcgacggag tcggcgatga tctccaggcc gcggccgagc tcggtctcgg tcacggtgag
     5581 cggcggcagc agcttgacca cctcgccctc cggaccggag gtctccatca gcagcccgcg
     5641 cttgaacgcc tcgccgcaga ccttgggggc cgtctccggg tccttcatga ccaggcccca
     5701 cgcgaggccg cggccgcgca ccgagtcgac ggcgccggcg tgcgacagcg cgatctcctc
     5761 cagcgcggtc tggacctgct ggcccttggc gagggtctgc ttctccatgc cctcgccggc
     5821 ccagtagtcc tccagggcgc cgacggcggt gacgaacgcg gggttgaagc cgcggaacgt
     5881 cccgttgtgc tcgccgggct cccagacgtc cagctcgcgg cgcatgaggg tcaccgcgaa
     5941 cggcaggccg tagccgctga gcgacttgga gaggcagacg atgtccgggg tgatcccggc
     6001 ctcctcgaag gagaagaacg cgccggtgcg gccgcagccc atctggacgt cgtcgacgat
     6061 caggaggatc tcgtggcggc ggcacaggtc ctgcagcccg cgcagccact cggcggtggc
     6121 gacgttgatg ccgccctcgc cctggaccgt ctcgacgatc acggcggcgg gcttgtcgag
     6181 gccgctgccg ctgtcgtcca gcatcgtgtc gaacagcagg aagtcgggcg tgcggccgtc
     6241 gaggtagttg tcgtagggca tcgcgacgcc gtgccccagc ggcacgccgg caccggtgcg
     6301 cttcatcgag ttgccggtga ccgccagcgc cccgagcgtc atgccgtgga aggcgttcgt
     6361 gaagctgacg acggtctcac gcccggtgta cttgcgcgcc agcttgaggg cggcctcgac
     6421 cgagttgttg cccgccgggc cggggaactg gaccttgtag tccaggccgc gcggcgacag
     6481 cacgaactcg ttgaaccgtt ccaggaactc ccgcttggcc gaggtgtaca tgtccaggct
     6541 gtggacgatg gagtcgctcg cgaggtagtc caggaggcgc cgtttcagct gcgggttgtt
     6601 gtgcccgtag ttcagcgtcc ccgcaccggc gaagaaatcg aggtaggtgc ggccgttctc
     6661 atcggtcatg tggctgccct gggcgctggt gaacaccgtg ggccaacccc tgcagtagcc
     6721 gcggacttcc gattccatgc gggcgaaagt gtccatgatt ctgcctccgg caggtcggga
     6781 tggagtgaag cggacgatcg ttgcgtcaga tcgtgcgtca gtcggtggcc ttgatcgggc
     6841 cgatccggaa gagcacctcg ggctcgtgtc ccccctcggg gaagtgctcc gagccgaaca
     6901 gcgggctgcg gacgagttcg cacccccggg cccgcgcgaa cgactcgaac atcgcggtgg
     6961 acgcggcgtt gtccggggtg acggtggcct ccaggtaccg gtggcctcgg gcggcgaggc
     7021 gatcggcgag ctcgtcgagc atgcgcctgg ccagtccttg cccgcggtgg tcatgatcga
     7081 ccgcgacctg ccacacgaag aacgtgtcgg cgctggacgg gcgggtgtag ccggtgatga
     7141 agccgcaggg gacacccgcg tcgcgggcga cgacggacgt gtcggcgaag tcgcggcacc
     7201 agagcgtgta gctgtacggc gagttgacgt ccaggacctt ggagtcccgg gccagccgcc
     7261 acatctcggg gccgtcggtc aggctgggct cctggagtcg cacgtcctcg ttcgtctcgt
     7321 tcgcgtccgg gcgtcgggtc gttgtttcca gggattgcgc tgccatgtcc aggcaactta
     7381 ccgaatcccg gcccgtgatc gcagagtaat gttatctgcg agatgtttag cgaggtcgcg
     7441 cagtgggtat ggtgatgtgc ttaacaattt cgcgggtgat taatcggtgc ggcggcccct
     7501 cggaaccggc atttccccgc gatacgcagg ggctactgcc gacttcgcct ccgggggcgt
     7561 agatcgcctt cctgaacgga agcttaatgt cctgtcatcg cttgaagggg cgatttgtgt
     7621 atcggttgtg tgaggtaagt cactaagatt taacgtgaac gacgcgagtg cggtgggcgt
     7681 cacgtcggcc aggggcggac ggcctccgca tcgcgccagg tggggcgagt gggggaggtg
     7741 gcgtcggcgc ggatcctggg aggggcgcgg atcaccctgc aagcccccga agggcttacc
     7801 tcggcggcag ggggaacgcg ccgtgcggta aggcgatctc aggtttcggg cgctccggac
     7861 gcccaccggg gcgggttccg gccggtgtga cgccgtccgg ttccggacgg ggcacatcgg
     7921 gggttgggga cggaccgtta gcgggatcgg gcgagcgggt cggacgaagg ctcggagcgg
     7981 cgggctcgcc cggccgggat cgggcgggcg gaggattcgg cgggcggggg actcagcggg
     8041 cggatgactc agcgggtgcg ggcgaaccgg tcggtcgcct cgatgaggtg atgcaggatt
     8101 cccggctcac tgtaggcgtg cccggcgtcg tcgacgatgt gcaggtccgc ctccggccac
     8161 gcgcggtgca ggtcccaagc cgtcgccacg ggcgtgcaca tgtcgtagcg gccctgcacg
     8221 atgacggccg ggatgtggcg gatcttgccg acgtcccgga tcagctggtc ctcctcgaag
     8281 aagccctcgt tcacgaagta gtggttctcg atccgggcga acgcgaccgc gtagtcgggt
     8341 tcgccgaagc cgctcgccag ctcctcgtcc gggcgcagcg tgagcgtcga cccctcccag
     8401 gtggaccagg cgcgggccgc cgccacccgg acgtcccggt cgggggagtt cagccgctcg
     8461 tggaacgcgg agacgaggtc ctcgcgctcg tcctcgggga tcggctcgac gtaccgctcc
     8521 cacagatcgg gaaagatcag cgacgcgccc tcctggtaga accagtacag ctcgaacggc
     8581 cgcagcgtga agatcccgcg caggaccagt tcggtgacgc gctccgggtg cgtctgcgcg
     8641 taggacagcg ccagcgcgct gccccagctc ccgccgaaga ccagccagcg gtcgatcccg
     8701 aggtgctcgc ggagccgctc catgtcggcc accagatgcc acgtggtgtt cgcctccagc
     8761 gacaccgcgg ggtccttcgc gtgcggctcg ctccggccgc agttgcgctg gtcgaacagc
     8821 acgatccggt acgcctcggg atcgaactgc cggcggtgcg ccgggctgca cccgccgccc
     8881 ggcccgccgt gcagcatgac ggcgggcttg ccctccgggt tcccgcagac ctcccagtac
     8941 acgcggttgc cgtcgcccac gtcgagcagc ccggagtcgt agggttcgat gggcgggtac
     9001 agcgtgcgga gctccatggt ccgggattgt cgcacccgcg cgcgctcgcg cgtccgtccg
     9061 ccgcgccgcg cccccggcga ccgtcaccga cggtgggcac ggggtggcgc gggggtgtga
     9121 gtcgtggcac cgtccgagga agcccgcacg gccccgtcca gggccgtgat agacggttga
     9181 tcaggcgcgc tgcgtgcgtg aacgccggac cgggagcacg aaactaaacc ccaaactggg
     9241 caaacgtttc gccggtccgg actagagtgc cttccgtgag cgaagcgacg agcctgcggg
     9301 cgaggagtga agcgagcgcc atgtccacgg gcggccccgc gcacacgacg tgcacaccag
     9361 ccccgcgaac gcggccccgg gccgccagtc gaggagagca gtgagcgagc tgaacggatc
     9421 gggtggttcg cgcggagtcc cggagccggg ctccccctgg cccgcgatgg gacgtgaccc
     9481 ctcccgcggg tcggacgtct ccgtgcctgc cgcccagcag ccgatccaga tgaccaaggc
     9541 cgaccagccc ggcgagaccg cccggccgga gcccgagcag cccgaggcgc agccctggga
     9601 catcgtcgag cggctccgcc agatggcgga cctcatcggc gacgccctcg ccgccggaga
     9661 gcgcaaggtc agcgaggcgc agaccgacgc cgcgtcgcag gtcacggccc tgcagtcgga
     9721 gaaggagtcg gcgcagcggg acgcggcggc ggcgtggggc gaggtgcagc gcgcgcgggg
     9781 gcaggccgag gaggccgacc gccgcgccgt cgaggccgaa cgccgcatca ccgacgtcca
     9841 ggccgacgcc gcgtcgcagg tctcggccgt ccagtcggag aaggagtcgg cgcagcggga
     9901 cgcggcggcg gcgtggggcg aggtgcagcg cgcgcggggg caggccgagg aggccgaccg
     9961 ccgcgccgtc gaggccgaac gcaagatcgc cgaggccgag cggcgcgcca ccgaggtgca
    10021 gaacgaggcc gtcgcccaga tcgccaacct ccagacggag aaggaggccg cccagcggga
    10081 cgcggccgcc gcctggaacc aggcgcagca gggacgtgcc caggccgacc aggcccgcgg
    10141 acaggccgag caggcgcgga tccaggccga ccaggcgcgc gcgcaggccg agcaggcccg
    10201 cacccagatg gagcaggccc aggggcaggc ggcacaggcc cgcgcccagg tcgagcaggc
    10261 cgaacaccgc gttgccgagg ccgaggcgac cgtccggcag gccatccagc agcgcgacgc
    10321 catgagcgag gcgcgcgacg acgcgctgcg cgccgtcgag gacgccgtcg gcggccgccg
    10381 cggcgccgag tccgaa
//
