LOCUS       NZ_CP044407            21053 bp    DNA     circular CON 28-JUL-2024
DEFINITION  Actinomadura sp. WMMB 499 strain WMMB499 chromosome, complete
            genome.
ACCESSION   NZ_CP044407
VERSION     NZ_CP044407.1
KEYWORDS    RefSeq.
SOURCE      Actinomadura sp. WMMB 499
  ORGANISM  Actinomadura sp. WMMB 499
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Thermomonosporaceae; Actinomadura.
REFERENCE   1  (bases 1 to 9187113)
  AUTHORS   Braun,D., Bugni,T.S., Chevrette,M.G. and Currie,C.R.
  TITLE     Draft genome of Actinomadura sp. WMMB499
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9187113)
  AUTHORS   Braun,D., Bugni,T.S., Chevrette,M.G. and Currie,C.R.
  TITLE     Direct Submission
  JOURNAL   Submitted (26-SEP-2019) Pharmacy, University of Wisconsin-Madison,
            777 Highland Ave., Madison, WI 53705, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Canu v. Oct-2016
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 300.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_008824145.1-RS_2024_07_28
            Annotation Date                   :: 07/28/2024 05:00:58
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,523
            CDSs (total)                      :: 8,413
            Genes (coding)                    :: 8,251
            CDSs (with protein)               :: 8,251
            Genes (RNA)                       :: 110
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 92
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 162
            CDSs (without protein)            :: 162
            Pseudo Genes (ambiguous residues) :: 0 of 162
            Pseudo Genes (frameshifted)       :: 64 of 162
            Pseudo Genes (incomplete)         :: 108 of 162
            Pseudo Genes (internal stop)      :: 10 of 162
            Pseudo Genes (multiple problems)  :: 19 of 162
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 04:12:41
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 8022855
            Orig. end                         :: 8043908
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP044407.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Genome not circularized.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21053
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="25"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..21053
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21053
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11053](-)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11053)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     misc_feature    153..167
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.98"
                     /tool="antismash"
     misc_feature    748..759
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.46"
                     /tool="antismash"
     gene            complement(1001..1783)
                     /locus_tag="F7P10_RS36525"
                     /old_locus_tag="F7P10_36525"
     CDS             complement(1001..1783)
                     /EC_number="2.8.1.10"
                     /GO_function="GO:1990107 - thiazole synthase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017546546.1"
                     /locus_tag="F7P10_RS36525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_36525"
                     /product="thiazole synthase"
                     /protein_id="WP_151016621.1"
                     /transl_table=11
                     /translation="MQEKHEDALVIAGEEFGSRLIMGTGGAPSMQVLREALTASGTELT
                     TVAMRRVDPAARGSVLDVLKECGIRVLPNTAGCFTAGEAVLTAKLAREALGTNWVKLEV
                     IADEHTLLPDPIELVEAAEQLVDDGFAVLPYTNDDPVLARRLEQAGCVAVMPLGSPIGS
                     GLGIRNPHNIELIVERAGVPVILDAGLGTASDAALAMELGCDAVLLATAVTRAQAPATM
                     AAAMRHAVAGGRLARQAGRIPRRRYAQASSPFEGIASM"
     gene            complement(1786..1986)
                     /gene="thiS"
                     /locus_tag="F7P10_RS36530"
                     /old_locus_tag="F7P10_36530"
     CDS             complement(1786..1986)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0009228 - thiamine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="thiS"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017565075.1"
                     /locus_tag="F7P10_RS36530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_36530"
                     /product="sulfur carrier protein ThiS"
                     /protein_id="WP_151016622.1"
                     /transl_table=11
                     /translation="MKVIVNGEPRELPAGTSVAAAVAAVSAAPSGVAAALNDEVVRRAS
                     WEATPLRDGDRLEVLTAVQGG"
     gene            complement(1983..3167)
                     /gene="thiO"
                     /locus_tag="F7P10_RS36535"
                     /old_locus_tag="F7P10_36535"
     CDS             complement(1983..3167)
                     /EC_number="1.4.3.19"
                     /GO_function="GO:0016647 - oxidoreductase activity, acting
                     on the CH-NH group of donors, oxygen as acceptor [Evidence
                     IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene="thiO"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1103: FAD dependent oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011291491.1"
                     /locus_tag="F7P10_RS36535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_36535"
                     /product="glycine oxidase ThiO"
                     /protein_id="WP_151016623.1"
                     /sec_met_domain="DAO (E-value: 8.4e-67, bitscore: 225.1,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEIIVIGAGIVGLAAAWRTAERGAGRGVRVTLVDPEPASGATAVA
                     AGMITPVSELAYGEEPLLRLNLASRDRYDTFVAELEELTGTSTGYRDDGLLQVAFDADD
                     LAVLDDLRRFQASLGLPVEALTGRECRRQEPMLAPGVRGGLLAPRDGSVDPRRLTAALL
                     AACEKAGVTLVRRRAAGVVVERDAAAGVRLEDGTVLRAGRVLLAAGPWSEDIEGLPPGT
                     VPSVRPVKGQVIRLRTRVPFLRRCVRGLVKGSPVYLVPRADDGEIVLGATQEELGFDTR
                     VTAGGLWELLRDARELLPGVTELEFAEVTAGLRPGSPDNAPVMGHADLPGLVLGTGHFR
                     HGVLLAPLSADVLSALLLDDPVPEVARPFSPDRFHAGSTPPRSTPPRSTTEVNR"
     misc_feature    complement(3152..3166)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.65"
                     /tool="antismash"
     regulatory      complement(3157..3270)
                     /bound_moiety="thiamine pyrophosphate"
                     /db_xref="RFAM:RF00059"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00059"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="TPP riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /regulatory_class="riboswitch"
     misc_feature    complement(3187..3200)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.18"
                     /tool="antismash"
     gene            3367..4602
                     /locus_tag="F7P10_RS36540"
                     /old_locus_tag="F7P10_36540"
     CDS             3367..4602
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1175: pyridine nucleotide-disulfide oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018658557.1"
                     /locus_tag="F7P10_RS36540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_36540"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_151016624.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1e-45, bitscore:
                     155.2, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MERVIVVGGGLAGVRALEALRKKGYEGALTLVSAERHRPYDRPPL
                     SKAVLAGDSDDTTVDADWDALRCELLLGERATALRPGEPGRGGVLATTAGELPFDGLVI
                     ATGAAPITLPGDGRQHVVRTIEDARELRGLLAPGARVAIVGAGWIGAEVATTAAKKGCA
                     VTVVEAADTPLANALGPEAGALTAPWYAEAGVELRTGVKVAEVDARGLVLAADGAAGRI
                     DADAVVVGVGVRPDLGWLAGSGLLLERGVVTDGSFRTCHEGAEPGTPGEYRPDIVAVGD
                     CAAWWSSRYGRRLLVEHWDTALNAPETAAATLLGEDAAYDAAPYFWSEQFGRMVQYAGN
                     HAASERMIRRGDTTGRKWALAWLTGDRLDAILTVDRPRDLVQARRAIAAGASVDPAVLA
                     DPDVPVRQAVRG"
     gene            4683..5057
                     /locus_tag="F7P10_RS36545"
                     /old_locus_tag="F7P10_36545"
     CDS             4683..5057
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012853357.1"
                     /locus_tag="F7P10_RS36545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_36545"
                     /product="Rv2175c family DNA-binding protein"
                     /protein_id="WP_151018516.1"
                     /transl_table=11
                     /translation="MHATVESALDPRTEALAGEWLTLPQTAALLGIKTNRMKQLISERK
                     LLAVRRGGEPMVPAAFIKDGQVIKGLSGTLTVLSDAGYSDVETVRWLFTADDTLPGTPV
                     DALTENRGTEVRRRAQALAF"
     gene            5146..5817
                     /gene="thiE"
                     /locus_tag="F7P10_RS36550"
                     /old_locus_tag="F7P10_36550"
     CDS             5146..5817
                     /EC_number="2.5.1.3"
                     /GO_function="GO:0004789 - thiamine-phosphate
                     diphosphorylase activity [Evidence IEA]"
                     /GO_process="GO:0009228 - thiamine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="thiE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1280: thiamine-phosphate pyrophosphorylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018658559.1"
                     /locus_tag="F7P10_RS36550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_36550"
                     /product="thiamine phosphate synthase"
                     /protein_id="WP_176611796.1"
                     /transl_table=11
                     /translation="MSRHLPSDRAVALRARLDRARLYLCTDAREERGDLPEFLDTVLAN
                     GVDIVQLRQKGLEARREMALLEVFRAACERHGALLAVNDRADVAHAVRADVLHLGQDDL
                     PVPAAREIVGGDVLIGRSTHAEEQASAAASEPGADYFCTGPTWPTPTKPGRPAPGLGLL
                     EYTAGRRFARPWFAIGGIDLGNLGEVLDTGARRVVVVRAITEAADPGAAAAEFARRLAA
                     V"
     misc_feature    5891..5906
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 18.05"
                     /tool="antismash"
     gene            5901..6059
                     /locus_tag="F7P10_RS42900"
     CDS             5901..6059
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019630836.1"
                     /locus_tag="F7P10_RS42900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_176611797.1"
                     /transl_table=11
                     /translation="MSVGPDDDRPVDLDDDFAVLPDQTSDDTDTGWGEWRGGDDDSRLL
                     EDRPPHW"
     gene            complement(6082..7053)
                     /locus_tag="F7P10_RS36555"
                     /old_locus_tag="F7P10_36555"
     CDS             complement(6082..7053)
                     /EC_number="2.7.11.1"
                     /GO_function="GO:0004674 - protein serine/threonine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012853354.1"
                     /locus_tag="F7P10_RS36555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_36555"
                     /product="serine/threonine-protein kinase"
                     /protein_id="WP_151016625.1"
                     /sec_met_domain="Pkinase (E-value: 6.7e-43, bitscore:
                     145.9, seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="APH (E-value: 3.5e-07, bitscore: 29.3,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSPAPRPSHAPSAAPPRASRRRPAAALGPGDPDDIGGHLLLGRLG
                     EGGQGIVYLAEDSGGEVCAVKLLKGGMAAGRRARDRFVKEADAARRVTGRHTARVLDAD
                     VTGDRPYIVSEYVDGPSLQEVVTEDGPLPERRLHRVAVGTAAALAAIHREGIVHRDFKP
                     GNVLLGPDGAKVIDFGIARMADATPLTTGPLGTPAYMSPEQIEDEPVGPPADVFAWGAA
                     MVFAATGRPPFGTGPNAAVMRRVTSRPPDLGDLDGPLRDLAARCLDKNPKARPSARQLV
                     RALREGAGPAPRPRPTRIPRYRWRMMVALALVMTAGFLIGIL"
     gene            complement(7143..9308)
                     /locus_tag="F7P10_RS36560"
                     /old_locus_tag="F7P10_36560"
     CDS             complement(7143..9308)
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018658561.1"
                     /locus_tag="F7P10_RS36560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_36560"
                     /product="glycoside hydrolase family 3 C-terminal
                     domain-containing protein"
                     /protein_id="WP_151016626.1"
                     /transl_table=11
                     /translation="MTLRTGTLRTGRWLPAVGALACALALAVVPAPPDGALAAASRCGD
                     PAVRPWCDTSKSADERARLLLAKLTDDEKIALLSSDDPFGGPLGGFFDWAHADTNHGIE
                     RLGVPPLYMADGPAGVRQGEATALPAPIALAATFDRDAARLYGRTVGWEARHRGNDVIF
                     GPTVDVLRTPLNGRTFEGFGEDPYLSARLGASWIEGAQGQGVMASVKHLAVYTQEKDRL
                     ELNMAVDPRTLREIYLPPFEAAVTEGGAATVMCGFGKLNGRWACHDGGVLNGILRSEWG
                     FDGMVMSDHTAAHDTAEAANGGLDMELPIGVRYNAFLLKTARAQNEVSQATIDGHTRNV
                     LRTMFEFGVFDRPAYPNDLARADRTASGTAARAIAEDGVTLLKNDGALPLSAPGKIALI
                     GRAARESQSGSGSAKVVPFEAVSAQEGLTRRAGAGASVTYRDGDDHGAAADAARGADVA
                     IVFATDSQGEFFDKSCLTLECGEPLRGDQDGLISAVAAANPNTIVVLQTGGPVLTPWAD
                     EVAAVVETWYPGQEAGNALARVLYGDVDPGGRLPVTFPAAETHAPAAGNPAQYPGVGKT
                     ATFSEGVMVGYRHYDERGIAPKYPFGHGLSYTTFRYSGLKVSSKRASVTVTNSGSRTGV
                     AVPQMYLGLPSPGVDVPQPPKQLKGFTKVTLEPGQSTTVTFPLSTRDLSYWNVEAKQWK
                     VADGCYRVMVGASSRDIAQQGAFGACG"
     gene            complement(9305..9868)
                     /locus_tag="F7P10_RS36565"
                     /old_locus_tag="F7P10_36565"
     CDS             complement(9305..9868)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1298: putative carboxymuconolactone decarboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019630833.1"
                     /locus_tag="F7P10_RS36565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_36565"
                     /product="carboxymuconolactone decarboxylase family
                     protein"
                     /protein_id="WP_151016627.1"
                     /transl_table=11
                     /translation="MCADTPGDRAPRIAPLPEERWDDVLKAVTAATGPLNVFTTLARHP
                     SLFQSWIGLGSALLMNGLLPGRDRELAILRTAHHRSCAYEWAHHRDLALAAGLTEEEID
                     ALRGDLGAHPWGDGDRMVLTAADELHERGTVTDATWVELAGRFGEAELIELVMLVGHYH
                     MVAFTLNALRVQSEDPGHRDGEGR"
     gene            complement(10001..11053)
                     /locus_tag="F7P10_RS36570"
                     /old_locus_tag="F7P10_36570"
     CDS             complement(10001..11053)
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013131595.1"
                     /locus_tag="F7P10_RS36570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_36570"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_151016628.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 1.8e-49, bitscore:
                     167.3, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTSRIRKEVDEALLAFVDRQRPGLLAISDDLSPLLGALDALLRG
                     GKRLRPAFCYWGWRAAGGGTDAGVVGAAASLELLQASALIHDDVMDSSDTRRGQPSVHR
                     RFEALHGAQGWPGDAAAFGEGTAILLGDLCLAWSAEMFETCGLDGERRRRGRTVYDLMR
                     TEVMCGQYLDMLEGTRGAATVATALRVVEYKSAKYTIERPLHLGAALAGARPDVPAALT
                     GYGLPLGIAFQLRDDVLGVFGDPAETGKPAGDDLREGKRTVLVALTLERSDAAQAAALE
                     RRLGDPELDRPGVDELRSIIEETGGLAACEAMIDRYLDEAERALRAAPITEEAREALAG
                     LAVAATSRRT"
     misc_feature    complement(11123..11137)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.34"
                     /tool="antismash"
     gene            11235..12200
                     /gene="metF"
                     /locus_tag="F7P10_RS36575"
                     /old_locus_tag="F7P10_36575"
     CDS             11235..12200
                     /EC_number="1.5.1.20"
                     /GO_component="GO:0005829 - cytosol [Evidence IEA]"
                     /GO_function="GO:0004489 - methylenetetrahydrofolate
                     reductase (NAD(P)H) activity [Evidence IEA]"
                     /GO_process="GO:0009086 - methionine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="metF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019630831.1"
                     /locus_tag="F7P10_RS36575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_36575"
                     /product="methylenetetrahydrofolate reductase [NAD(P)H]"
                     /protein_id="WP_151016629.1"
                     /transl_table=11
                     /translation="MRPVRPDRPPTVRELLATGGRSFSFEFFPPKTEKGARTLWRTIRE
                     LEPLQPTFVSVTYGAGGGTRDTTVDIVERIATDTTLTPVAHFCAVNHSQAELRHLIGRL
                     AAAGVRNMLALRGDPPGDPMGEWISHPDGVEYAADLVRLIRATGDFSVGVAAFPYKHPR
                     SPDIESDTRYFIEKCRAGADYAITQMFFRAEDYFRLRDRVAAAGCDVPIIPGIMPVTQL
                     STIERSEQLSGAPFPPEVKARFDAVADDPEAVRRLGIEHAAELCRDLLDQGAPGIHFIT
                     FNKSTATREVYGLLEADGYCGTSAPAAEPVASGSVPPMTA"
     gene            complement(12131..12739)
                     /locus_tag="F7P10_RS36580"
                     /old_locus_tag="F7P10_36580"
     CDS             complement(12131..12739)
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013154124.1"
                     /locus_tag="F7P10_RS36580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_36580"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_254716209.1"
                     /transl_table=11
                     /translation="MRDAKLREIDERAFLRRVAPMLDVYAAAMSPPAEQLPGRRMIMER
                     HAGYPGFRAFAAERRGALARLPGPLHGFAYGFHGARGQWWHDVVIEALTARGGPEHAAA
                     WLEDAFEVAELHVRPDAQGRGLGRGLLAALCEGRPERTVVLSTLERRPDTPARRLYRSV
                     GMVDLLTDFEFPGGGPRYAVMGGTLPLATGSAAGADVPQ"
     gene            complement(12750..13079)
                     /locus_tag="F7P10_RS36585"
                     /old_locus_tag="F7P10_36585"
     CDS             complement(12750..13079)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012853350.1"
                     /locus_tag="F7P10_RS36585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_36585"
                     /product="hypothetical protein"
                     /protein_id="WP_151016630.1"
                     /transl_table=11
                     /translation="MSAPPPGSLPPPLEGAAAAALPLTERPNPAYAQLYRAYADAYGGI
                     DRLRQALDAPVKTLGGTDAWLGPEARRWGSALDAERARLRQAADRILWDIYDRLSATPR
                     TLPRG"
     gene            complement(13076..13978)
                     /locus_tag="F7P10_RS36590"
                     /old_locus_tag="F7P10_36590"
     CDS             complement(13076..13978)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="F7P10_RS36590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="F7P10_36590"
                     /product="hypothetical protein"
                     /protein_id="WP_151016631.1"
                     /transl_table=11
                     /translation="MTAQMRTGPAARDPNFRGIDPPALDRLITQMRDAQTAIRGWLNGH
                     RPPPGVSAAGYRQADEVAQWVGSQLGMLSRRYNYAITHPDGGSMQAPPSPAPSPEAGRA
                     PVEAGGAAPAPVAPPRRDPVAQAPRTPDPGRAKAPPAGGGLSSRGAGDIGSHPDRRAAE
                     KAAEADARALRAAFEDGAAVPAAVWTRLKADADDPDYTARLYERLGPAGTARLLAAGEG
                     DAARLRVIRESLGMASNEVRMDVAWLRAFLAEAERVGVRPVAVQVLTGVDWSARTQEAV
                     GKLDLATSEQDPAAPRRDP"
     misc_feature    complement(14018..14035)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.6"
                     /tool="antismash"
     gene            complement(14030..14383)
                     /locus_tag="F7P10_RS36595"
                     /old_locus_tag="F7P10_36595"
     CDS             complement(14030..14383)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018658568.1"
                     /locus_tag="F7P10_RS36595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_36595"
                     /product="arsenate reductase family protein"
                     /protein_id="WP_151016632.1"
                     /transl_table=11
                     /translation="MTEIWHNPRCSKSRAAKAALDEAGADYTERRYLDDPPTADELDAV
                     LTRIGAEPWEVARLGEAVAKDLGLKELERDRARWIEVMVANPVLIQRPIVVTGTAAIVA
                     RDEDSVRKALDSL"
     gene            complement(14383..14847)
                     /locus_tag="F7P10_RS36600"
                     /old_locus_tag="F7P10_36600"
     CDS             complement(14383..14847)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012889494.1"
                     /locus_tag="F7P10_RS36600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_36600"
                     /product="YbaK/EbsC family protein"
                     /protein_id="WP_151016633.1"
                     /transl_table=11
                     /translation="MHPNAEHVASVLQGHGVEGEIVELPDSAPTARAAADQVGCAVGAI
                     ANSLVFDADGAPLLVLTSGAHRVDTAKVAGLVGARRVRRATPEFVREATGQPIGGVAPV
                     GHPAPIRTLVDVWLGGHDRVWAAAGHPHTVFPTSYEELLKITGGDPAEVE"
     misc_feature    complement(14803..14813)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.94"
                     /tool="antismash"
     misc_feature    14931..14946
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: medium, score: 25.93"
                     /tool="antismash"
     misc_feature    complement(14932..14945)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: strong, score: 24.0"
                     /tool="antismash"
     gene            15080..15562
                     /locus_tag="F7P10_RS36605"
                     /old_locus_tag="F7P10_36605"
     CDS             15080..15562
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018658573.1"
                     /locus_tag="F7P10_RS36605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_36605"
                     /product="SAV_6107 family HEPN domain-containing protein"
                     /protein_id="WP_151016634.1"
                     /transl_table=11
                     /translation="MSATAVHSAALSGPPSPRRRPRPAPRPAHTAVGQLQAARTGLAEA
                     AEATTPAVRYVCAHLAALRAAAAVLASREPVETHHRGRPRSVWVLLPEAEPALREWAAF
                     FAAGADKRAAAEAGLPRAVTVREAEELLHDAEIFVSLVEDCLGIAGQTALPFTDAN"
     gene            15733..16911
                     /locus_tag="F7P10_RS36610"
                     /old_locus_tag="F7P10_36610"
     CDS             15733..16911
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0008410 - CoA-transferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1189: L-carnitine dehydratase/bile acid-inducible"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018657057.1"
                     /locus_tag="F7P10_RS36610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_36610"
                     /product="CoA transferase"
                     /protein_id="WP_151016635.1"
                     /transl_table=11
                     /translation="MDALLPLAGMRIVEISSFVAAPLGGMTLAQLGAEVIRVDQIGGGP
                     DIDRWPLAPSGRSLYWAGLNKGKRSVTVDLRSAEGRGVAARLAAECGTVLTNAPPRGGL
                     APAELAALRPDLVHVQLVGRRDGGTAVDYTVNAASGFPAITGRDGAPVNHALPVWDVVC
                     GLYLAAGLLAAERHRLRTGEGSGLRVALDDIALATAGNLGYLAEAQLGTPRERIGNHLF
                     GEFGRDFATADGRVMVAVVTGRQWRDLVAATGLGEVVEALERALRADFGTAGDRYRHRE
                     AIGGLLASWFGTRTCAEIEAGLHGTSVLWSRYRDFGEVARELDGRPLMAEIDQPGVGPH
                     LAPGSPLVFGGQAPPGPAPVLGEDTAGVLRDVLGLSGDAVDDLRARGVAGEP"
     gene            complement(16973..17341)
                     /locus_tag="F7P10_RS36615"
                     /old_locus_tag="F7P10_36615"
     CDS             complement(16973..17341)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019611512.1"
                     /locus_tag="F7P10_RS36615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_36615"
                     /product="VOC family protein"
                     /protein_id="WP_151016636.1"
                     /transl_table=11
                     /translation="MFKDTKAYSGFSVDDIEAAREFYGEVLGLGVSEDHGMLTLHIAGD
                     RDTLVYPKPDHTPATFTILNFPVDDIERAVDELGERGVAFEQYDGYTDAKGIMREMGPL
                     IAWFRDPAGNVLSVLQEA"
     misc_feature    complement(17431..17447)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 14.89"
                     /tool="antismash"
     gene            17470..18897
                     /locus_tag="F7P10_RS36620"
                     /old_locus_tag="F7P10_36620"
     CDS             17470..18897
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012853344.1"
                     /locus_tag="F7P10_RS36620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_36620"
                     /product="MFS transporter"
                     /protein_id="WP_254716210.1"
                     /transl_table=11
                     /translation="MAARGGRGLVPLLAFLGVSAYSLSMAVVTPALPQIQAGLGTTPAG
                     AAWALTAMTLSAAVATPVVGRLGDLYGPRRVLLSVLAAATAGMVVAASAGSLPVMLAGR
                     VLSGVGAGVFPLAYTIIRDVVPAGRTASAVGLMSSMLGLGGALSWCMAGPIIDLLGWRW
                     LLWVPVLGLVPGLAAAWWIVPRSPSRAGARVDWWGAVLFAGWLVAALAALTQGTFWGWT
                     SPGVLGLLAAAVVTAAIWLWVETRVREPLVDPRVMRLRGVWTANAASLLSGYALMAGGL
                     LFPLLVQLPEDTGYGFGGSATQAAVLQLPASIGMTVAGVAAGALDRRFGSRAVLSGGAV
                     LTCAGYAFVTFAHSELWHLYVGGLARGIGLGLAYAAVATLVVLAVPVGDTGAATGVNTL
                     IRTVGASLGTQVSAVIVAGMPGERGFTAGFAMSAAAMAAVLPLALLAARGGGRARGAGG
                     EPVVRPSITTADARDGA"
     gene            complement(18904..19494)
                     /locus_tag="F7P10_RS36625"
                     /old_locus_tag="F7P10_36625"
     CDS             complement(18904..19494)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF044515.1"
                     /locus_tag="F7P10_RS36625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_36625"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_151016637.1"
                     /transl_table=11
                     /translation="MPEPGRPLRADARRNRARVLEAARTVLARDGSSASLREIAREAGV
                     GLATIYRQFPTKEDLFAAVVRDRIGALADEAAALIAGSGGTAPGAAFFTFFTLIVEDST
                     HKKMLVDALTDAGVAEADVKAGMADLAAEIKDSLATLLAGAQRSGDVRADVGMPEVLAL
                     LGAACLAAERGRWDAGTRDRALAVVFDGFRPRN"
     misc_feature    19520..19534
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.9"
                     /tool="antismash"
     misc_feature    complement(19554..19568)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.43"
                     /tool="antismash"
     misc_feature    19555..19568
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 17.99"
                     /tool="antismash"
     misc_feature    19555..19569
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.9"
                     /tool="antismash"
     gene            19608..20645
                     /locus_tag="F7P10_RS36630"
                     /old_locus_tag="F7P10_36630"
     CDS             19608..20645
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012472.4"
                     /locus_tag="F7P10_RS36630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_36630"
                     /product="aldo/keto reductase"
                     /protein_id="WP_151016638.1"
                     /transl_table=11
                     /translation="MEYATLGRSGLKVSQACLGTMNFGTDHPFAGCTEDEARRVVDAFL
                     DAGGNVIDTADAYTGGQSEEIVGRAVAGRRDSVVLATKAFMPQGDGPNDIGLSRAHLTR
                     ALEASLRRLGTDHIDLYQCHQWDAATPIEETMATLDGFVRSGKVRYIGCSNFTAAQIVE
                     ARRAAERAGGTPFVSLQPQYSLVARAIEAEILPACERHGLGTLTYSPLANGVLTGRYAR
                     GAAPADSRIGRLRSSPLDMARRYAGDMLNERTLGIAAEVGAVAAELGAASAAVALAWVR
                     ARPGVTSVIVGPRDLEQLRGNLAGFALELPDEAAARLDEVSRATVLPPVTGMQVRHHAE
                     VARAS"
ORIGIN
        1 gaccgccccg gggacctcgt cgagcagcgc ccacgacatc agcacgacga gggcgggaac
       61 cgcgtaggtc gtcgcgccca tcctcccggc ggacgtgcgg gccagcgcgt agccccacgt
      121 ggtgaaggcg agcgcggtcg ggaagacgcc gaggtagatc atgttcaggg tcgcccccgc
      181 cggggcgtcg gcggcctgct ccgcgagccg cccggcgaac ggcagcgtcg ccgcggcgcc
      241 gatcgcgcac gcgaacgtgg tgaactgcag cgcggacgcg tgccgcagcg ccggcttctg
      301 gctgacgacc ccgcccgcgt aggtgacggc cgcgaccacg cacagcagga cgccgagcag
      361 cggtgatccc gtcttgccgg cgatcggctc gccggacatc gacagcccga cgacggcggc
      421 gcccgcgaac gccacggcca ggcccgcgag cagccgggag gagaagccct ccttcagcag
      481 ccagccgccg aggagggcga tcaggatggg cccgatgttg acgacgaggg cggcggtgcc
      541 ggcgtccacg agctgctcgc cccagttgag cgcgaccatg tagacgccga accacaggat
      601 gcccgcggcg acgatgccgg gccacgcgcc gcgcggcggg aggccctcgc ggcggacgag
      661 ccacagggcg ccgagcacga cggtgccgga gagcagccgg ccgagcgcga gcgggccggg
      721 gtcgtacgcc tcgcccgcgc tgcggatgga gacgaacgcc gacgcccaga gcaccaccgt
      781 cacggtggcg gcggcgacgg cccgccggtc ggcgcccttc gcgggcgcgg gaggggagct
      841 tccctgttcc atgaagcgca ccttaggtcg gggacgtttc gctgaacccc gaagttcggc
      901 gcgcggttgc gcggccggac accgatgggc cgcccccagt ctgggagcgg cccatcgttc
      961 aggtccagcg attaatgctt gatgtctccg ttaaggtctg ctacatcgac gcgatgccct
     1021 cgaagggcga cgacgcctgc gcgtagcggc gcctggggat ccgccccgcc tgccgcgcca
     1081 gccgcccgcc cgcgacggcg tgccgcatcg cggcggccat cgtcgcgggg gcctgcgcgc
     1141 gggtcacggc agtggccagc agcaccgcgt cgcagcccag ctccatggcc agggcggcgt
     1201 cgctcgcggt gccgagcccg gcgtccagga tgaccgggac gcccgcccgt tcgacgatca
     1261 gctcgatgtt gtgcgggttg cggatgccga gccccgagcc gatgggggag ccgagcggca
     1321 tcaccgcgac gcagccggcc tgctcgagcc gccgcgccag gacgggatcg tcgttggtgt
     1381 acggcagtac ggcgaacccg tcgtcgacga gctgttccgc ggcctcgacc agttcgatcg
     1441 ggtcgggcag cagcgtgtgc tcgtccgcga tcacctcgag cttgacccag ttcgtcccga
     1501 gcgcctcgcg ggcgagcttg gcggtcagca ccgcctcgcc cgcggtgaag cagcccgcgg
     1561 tgttgggcag cacgcggatg ccgcactcct tgaggacgtc cagcaccgag ccgcgcgccg
     1621 cggggtccac ccgccgcatc gcgaccgtgg tcagttccgt cccggacgcg gtcagcgcct
     1681 cccgcagcac ctgcatgctg ggcgcgccgc ccgtccccat gatgagccgc gagccgaact
     1741 cctcgcccgc gatcaccagc gcgtcctcgt gcttctcctg catggtcagc ccccctgtac
     1801 ggcggtcagc acttccaggc ggtcgccgtc gcgcagcggc gtcgcctccc aggacgcccg
     1861 gcggacgacc tcgtcgttca gcgcggccgc cacaccggac ggcgccgcgc tcacggccgc
     1921 gaccgcggcg gccacgctgg tgcccgcggg cagctcgcgc ggctcaccgt tgacgatgac
     1981 cttcatcggt tcacctctgt agtcgaacgg ggcggggtcg atcggggcgg ggtcgatccg
     2041 gcgtggaagc gatcggggga gaacgggcgg gcgacctcgg gcaccgggtc gtcgagcagc
     2101 agcgcggaca ggacgtccgc cgagagcggc gcgagcagga cgccgtggcg gaagtgcccg
     2161 gtgccgagga cgagcccggg gaggtccgcg tggcccatca ccggggcgtt gtccggggag
     2221 ccgggccgca gccccgccgt gacctcggcg aactccagct cggtgacgcc ggggagcagc
     2281 tcgcgggcgt cccgcagcag ctcccacagg ccgcccgccg tcacgcgcgt gtcgaacccg
     2341 agttcctcct gcgtggcgcc gaggacgatc tcgccgtcgt ccgcgcgcgg caccaggtac
     2401 accggcgacc ccttcaccag cccgcgcacg cagcgccgca ggaacgggac gcgggtgcgc
     2461 agccggatca cctgtccctt gacggggcgc acggatggaa cggtcccggg gggcaggccc
     2521 tcgatgtcct ccgaccaggg accggcggcc agcaggacgc ggccggcccg caggaccgtc
     2581 ccgtcctcga gccggacgcc cgccgccgcg tcgcgctcga cgaccacgcc cgccgcgcgc
     2641 cgccgtacga gcgtcacgcc ggccttctcg cacgcggcca gcagcgcggc ggtgaggcgg
     2701 cgcgggtcga ccgagccgtc gcggggggcg agcaggccgc cgcggacgcc cggtgccagc
     2761 atcggctcct gcctgcggca ctcccgcccg gtcagcgcct cgacggggag ccccagactc
     2821 gcctggaagc gccgcaggtc gtccaggacg gccaggtcgt cggcgtcgaa cgcgacctgg
     2881 agcaggccgt cgtcgcggta gccggtgctc gtgccggtca gctcctccag ttccgcgacg
     2941 aacgtgtcgt agcggtcgcg ggaggccagg ttcaggcgca gcagcggctc ctcgccgtag
     3001 gccagctcgc tgacgggggt gatcatgccc gcggcgacgg ccgtggcgcc gctcgcgggc
     3061 tcgggatcga cgagggtcac ccggacgccg cgtccggcgc cccgttcggc ggtccgccag
     3121 gcggcggcga ggccgacgat cccggccccg atgacgatga tctccatgtg cgctcccttc
     3181 gccggcatga tccggatcag gtcgtggcgg tcggcggccc gttcagccgc cctctcagcc
     3241 cggtcgcacc ggactcccgc gtctgtcgtg ctttacgtgc tcttctccca ctttacgacc
     3301 gctgtgacgt acacgatcgt ctggacaggt gtccaggcga atccggcgcc cattagggtg
     3361 catggcatgg agagggtcat cgtcgttggt ggcgggctgg cgggcgtgcg cgccctggaa
     3421 gccctgcgca agaaggggta cgagggcgcg ctcaccctcg tctcggccga gcggcaccgg
     3481 ccgtacgacc ggccgccgct gtcgaaggcc gtcctcgcgg gcgactccga cgacaccacc
     3541 gtcgacgccg actgggacgc gctgcgctgc gagctcctgc tcggcgagcg cgccaccgcg
     3601 ctgcgccccg gcgagcccgg acgcggcggc gtcctggcca ccacggccgg ggaactgccg
     3661 ttcgacggcc tcgtgatcgc gaccggcgcc gctccgatca cgcttccggg ggacggccgc
     3721 cagcacgtcg tccgcaccat cgaggacgcc cgcgaactgc gcggcctgct cgcccctggc
     3781 gcccgcgtcg cgatcgtcgg ggcgggctgg atcggcgccg aggtcgccac gaccgccgcg
     3841 aagaagggct gcgcggtcac cgtcgtcgag gccgccgaca cgcccctcgc gaacgccctc
     3901 ggtcccgagg cgggcgcgct gaccgccccc tggtacgccg aggcgggcgt cgagctgcgc
     3961 accggcgtca aggtcgccga ggtcgacgcc cgcggcctcg tcctcgccgc cgacggggcg
     4021 gccgggcgga tcgacgcgga cgcggtcgtc gtcggcgtcg gcgtccgccc ggacctcggc
     4081 tggctcgccg gatccggcct gctgctggag cgcggcgtcg tcaccgacgg gtccttccgc
     4141 acctgccacg agggcgccga gcccggcacc cccggcgagt accgccccga catcgtcgcc
     4201 gtcggggact gcgcggcctg gtggtcgtcc cggtacggac ggcggctcct ggtcgagcac
     4261 tgggacaccg ccctcaacgc cccggagacc gccgccgcga ccctcctcgg cgaggacgcc
     4321 gcctacgacg ccgcccccta cttctggtcc gagcagttcg gccggatggt ccagtacgcc
     4381 gggaaccacg cggcgtccga gcggatgatc cggcgcggcg acaccaccgg gcgcaagtgg
     4441 gccctcgcgt ggctcaccgg cgaccgcctc gacgcgatcc tcaccgtcga ccgcccccgc
     4501 gacctcgtcc aggcgcggcg ggcgatcgcg gccggggcgt ccgtcgaccc ggccgtcctc
     4561 gccgatccgg acgtgcccgt ccgccaggcc gttcgcggct agcggagccg gtccgaaaaa
     4621 ccggtggtcg tccggggggt ttgagcgatt cggcggcgtg gtagcaaggg ggcgtgacgc
     4681 agatgcacgc aaccgttgaa agcgcactcg acccccgcac cgaggccctc gccggcgagt
     4741 ggctcaccct cccgcagacc gccgcgctgc tcggcatcaa gaccaaccgg atgaagcagc
     4801 tcatcagcga gcgcaagctc ctggcggtcc gccgcggggg cgagccgatg gtcccggccg
     4861 ccttcatcaa ggacggccag gtgatcaagg gcctgtccgg gacgctcacc gtgctctcgg
     4921 acgccggcta cagcgacgtc gagaccgtcc gctggctgtt caccgcggac gacacgctgc
     4981 ccgggacacc ggtcgacgcg ctcaccgaga accgggggac cgaggtgcgc cgccgcgccc
     5041 aggccctggc gttctgacgg ttccacccga cccgaacacg tgacaccggg ggtcacgcgc
     5101 ccgcgtggcc cccgcagccc tgcccgaaag gaagacctcc cgaccgtgtc caggcacctg
     5161 ccctccgacc gagccgtggc gctgcgcgcc cggctcgacc gcgcccgcct ctacctctgc
     5221 acagacgcgc gggaggagcg gggcgacctg cccgagttcc tggacaccgt cctcgcgaac
     5281 ggcgtggaca tcgtccagct ccggcagaaa ggcctggagg cgcggcggga gatggcgctc
     5341 ctggaggtgt tccgggccgc gtgcgagcgg cacggcgcgc tgctggccgt caacgaccga
     5401 gcggacgtcg cgcacgccgt ccgcgccgac gtgctgcacc tcggccagga cgacctgccg
     5461 gtgccggccg cccgcgagat cgtcggcggg gacgtgctga tcggccggtc cacccacgcg
     5521 gaggaacagg cgtccgccgc cgcgtccgag cccggcgccg actacttctg caccgggccg
     5581 acctggccca ccccgaccaa gcccggacgt cccgcccccg gcctcgggct gctggagtac
     5641 accgccgggc ggcgcttcgc gcggccgtgg ttcgcgatcg gcggcatcga cctgggcaac
     5701 ctgggcgagg tgctggacac cggcgcccgc cgcgtcgtgg tggtgcgggc gatcaccgag
     5761 gccgccgacc ccggcgccgc ggcggccgag ttcgcgcgcc gcctcgccgc cgtgtgaccg
     5821 gccgtgtgac cggccgtgtg accggccgtg tgacccggcg cacggttccc cggtgcgcgg
     5881 catgccgcac aatggggatc atgagcgtgg gacccgacga cgaccggccg gtcgacctcg
     5941 acgacgactt cgccgtcctg cccgaccaga cgtccgacga caccgacacc ggctggggcg
     6001 agtggcgcgg cggcgacgac gactcacgcc tgctggagga ccggccgccg cactggtgac
     6061 ccgtccggcc tccgccgtcg gctagaggat gccgatgagg aagcccgccg tcatcaccag
     6121 ggccagcgcc accatcatgc gccagcggta gcgcgggatg cgggtggggc gcggccgggg
     6181 cgccgggccc gcgccctcgc gcagcgcccg gacgagctgc cgcgcggacg gcctggcctt
     6241 cgggttcttg tcgaggcagc gggccgcgag gtcgcgcagc ggcccgtcga ggtcgccgag
     6301 gtccggcggg cgggacgtca cccggcgcat caccgcggcg ttcggcccgg tcccgaacgg
     6361 ggggcggccg gtggccgcga acaccatcgc cgcgccccac gcgaacacgt ccgcgggcgg
     6421 ccccaccggc tcgtcctcga tctgctcggg ggacatgtag gcgggggtgc cgagcggccc
     6481 cgtggtcagc ggcgtcgcgt ccgccatccg cgcgatgccg aagtcgatga ccttggcgcc
     6541 gtccgggccg agcagcacgt tgcccggctt gaagtcgcgg tgcacgatcc cctcgcggtg
     6601 gatcgcggcg agcgccgcgg ccgtgccgac ggcgacgcgg tgcagccgcc gctccgggag
     6661 cggcccgtcc tcggtcacga cctcctgcag cgacgggccg tccacgtact cgctgacgat
     6721 gtagggccgg tcgccggtca cgtccgcgtc cagcacccgc gcggtgtgcc gtccggtgac
     6781 ccgccgcgcc gcgtcggcct ccttgacgaa ccggtcgcgg gcgcgccgcc cagccgccat
     6841 cccgcccttc agcaacttga ccgcgcacac ctcgccgccg ctgtcctcgg cgaggtagac
     6901 gatgccctgg ccgccctcgc cgagcctgcc cagcaggagg tggccgccga tgtcgtccgg
     6961 atcgccgggc cccagcgcgg ccgcgggacg gcgccgcgag gcgcggggcg gggcggcgga
     7021 cggggcgtgg gacggccggg gcgctgggga cacgggggac tccggcgggg agacggaagt
     7081 gaaaaggggt ccttatttgt accgtgtgac cgtcctgtcc tgcagcggaa cgaggatctt
     7141 ctttacccgc acgccccgaa ggccccctgc tgggcgatgt cccgcgacga ggcgccgacc
     7201 atgaccctgt agcagccgtc cgcgaccttc cactgcttcg cctccacgtt ccagtaggac
     7261 aggtcacggg tgctgagcgg gaaggtgacg gtcgtgctct gccccggctc cagcgtgacc
     7321 ttcgtgaagc ccttgagctg cttgggcggc tgcgggacgt ccacaccggg cgacggcaga
     7381 ccgaggtaca tctgcgggac ggccacgcct gtgcggctcc cgctgttggt gaccgtcacg
     7441 ctggcccgct tcgaggagac cttcaagccg ctgtagcgga acgtcgtgta cgacaggccg
     7501 tgaccgaacg ggtacttggg cgcgatgccc cgctcgtcgt agtgccggta gccgaccatg
     7561 acgccctcgg agaacgtcgc ggtcttgccc acccccgggt actgcgccgg gttcccggcc
     7621 gcgggcgcgt gcgtctccgc ggcggggaag gtcaccggca ggcgcccgcc cggatcgacg
     7681 tccccgtaca ggacgcgggc cagcgcgttc cccgcttcct gccccggata ccaggtctcg
     7741 acgaccgccg cgacctcgtc cgcccacggg gtgaggacgg gcccgcccgt ctgcagcacg
     7801 acgatcgtgt tcgggttcgc cgccgcgacc gccgagatca gcccgtcctg gtcgccgcgc
     7861 agcggctccc cgcactccag cgtcaggcac gacttgtcga agaactcgcc ctggctgtcg
     7921 gtcgcgaaca cgatcgcgac gtcggcgccg cgcgcggcgt ccgccgccgc gccgtggtcg
     7981 tccccgtccc ggtaggtgac cgaggcgccc gccccggccc gccgggtcag cccctcctgt
     8041 gcgctcaccg cctcgaacgg gacgaccttc gccgacccgg aaccggactg gctctcccgc
     8101 gcggcccgcc cgatcagcgc gatcttcccg ggcgcgctca ggggcagggc gccgtcgttc
     8161 ttcagcagcg tgacgccgtc ctcggcgatc gcgcgggccg cggtcccgct cgccgtccgg
     8221 tcggcgcggg cgaggtcgtt cgggtacgcc ggacggtcga agacgccgaa ctcgaacatc
     8281 gtccggagga cgttgcgggt gtgcccgtcg atcgtggcct ggctgacctc gttctgcgcg
     8341 cgcgccgtct tgagcaggaa cgcgttgtag cggacgccga tcggcagctc catgtccagc
     8401 ccgccgttgg cggcctcggc ggtgtcgtgc gcggcggtgt ggtcggacat gaccatcccg
     8461 tcgaagcccc actccgaccg caggattccg ttgaggacgc cgccgtcgtg gcacgcccag
     8521 cggccgttca gcttcccgaa cccgcacatg acggtcgcgg cgccgccctc ggtcacggcg
     8581 gcctcgaacg gcggcaggta gatctcgcgg agcgtgcgcg ggtccaccgc catgttcagc
     8641 tcgaggcggt ccttctcctg ggtgtagacg gccaggtgct tcaccgacgc catcacgccc
     8701 tgcccctgcg cgccctcgat ccaggacgcg ccgagccggg ccgacaggta cgggtcctcg
     8761 ccgaacccct cgaacgtccg gccgttgagg ggcgtgcgca gcacgtccac cgtcgggccg
     8821 aagatcacgt cgttgccgcg gtgcctggcc tcccacccga ccgtccgccc gtacagccgc
     8881 gcggcgtccc ggtcgaacgt cgcggccagc gcgatcggcg cgggcagcgc ggtggcctcg
     8941 ccctgccgga cgcccgccgg gccgtcggcc atgtacagcg gcggcacgcc cagccgctcg
     9001 atgccgtggt tggtgtcggc gtgcgcccag tcgaagaacc cgccgagcgg gccgccgaac
     9061 gggtcgtcgg acgacaacag cgcgatcttc tcgtcgtcgg tcagcttcgc gagcagcagc
     9121 cgcgcccgct cgtccgcgct cttcgaggta tcgcaccacg gccgcaccgc cgggtcgccg
     9181 cagcggctcg cggccgccag cgccccgtcc ggcggggcgg ggacgaccgc gagcgccagc
     9241 gcgcacgcga gcgcgcccac cgcgggcagc caccgcccgg tccggagcgt tccggtccgg
     9301 agcgtcatcg gccctccccg tcccggtgcc cggggtcctc gctttggacg cgcagcgcgt
     9361 tcagcgtgaa cgcgaccatg tggtaatggc cgacgagcat caccagttcg atcagttcgg
     9421 cctcgccgaa gcggccggcc agctccaccc acgtcgcgtc cgtcaccgtg ccgcgctcgt
     9481 gcagctcgtc cgcggcggtc agcaccatcc ggtcgccgtc gccccacggg tgcgcgccga
     9541 ggtcgccgcg gagcgcgtcg atctcctcct cggtgagccc cgcggccagc gcgaggtcgc
     9601 ggtggtgcgc ccattcgtac gcgcaggagc ggtggtgcgc cgtccgcagg atcgccagct
     9661 cgcgatcccg gcccggcagc aggccgttca tcagcagcgc cgacccgagg ccgatccagg
     9721 actggaacag cgacgggtgg cgggccagcg tcgtgaagac gttcagcgga ccggtggcgg
     9781 cggtgacggc cttgagcacg tcgtcccacc gctcctccgg cagcggggcg atgcgcgggg
     9841 cgcggtcccc gggggtgtcg gcgcacatgg cgacatttct gccaccaaat ggtgggaaag
     9901 tgctagtgcg atcgggtcga ttggccggat cgtgccagat gttccggccg gccggacgga
     9961 cgggtcaggt gcgccgggag ggtcaggtgc ggcggacggg tcaggtgcgg cgggaggtgg
    10021 ccgcgaccgc caggcccgcg agcgcctccc gcgcctcctc ggtgatcggc gccgcccgca
    10081 gcgcccgctc ggcctcgtcg aggtaacggt cgatcatcgc ctcgcacgcc gcgagcccgc
    10141 cggtctcctc gatgatcgag cgcagctcgt ccaccccggg ccggtccagc tccggatcgc
    10201 cgaggcgccg ctcgagcgcc gccgcctgcg ccgcgtccga ccgttcgaga gtcagcgcga
    10261 ccagcaccgt ccgcttgccc tcccgcaggt cgtcgcccgc cggcttgccc gtctcggccg
    10321 gatcgccgaa cacgcccagg acgtcgtcgc ggagctggaa cgcgatgccg agcggcagcc
    10381 cgtacccggt cagcgcggcg gggacgtccg ggcgcgcccc ggccagcgcc gcgcccaggt
    10441 gcagcggccg ctcgatcgtg tacttcgcgc tcttgtactc cacgacccgc agcgccgtgg
    10501 cgacggtcgc ggcgccgcgc gtcccctcca gcatgtcgag gtactggccg cacatgacct
    10561 cggtgcgcat caggtcgtac accgtccggc cgcgccggcg gcgctcgccg tccaggccgc
    10621 acgtctcgaa catctccgcc gaccaggcca ggcacaggtc gccgagcagg atcgcggtgc
    10681 cctcgccgaa cgccgccgcg tcgcccggcc agccctgcgc gccgtgcagc gcctcgaacc
    10741 ggcggtgcac cgacggctgc ccgcgccggg tgtcgctgga gtccatgacg tcgtcgtgga
    10801 tcagcgcgct cgcctgcagc agttccaggg acgccgccgc gccgacgacg cccgcgtccg
    10861 tcccgccgcc cgcggcgcgc cacccccagt agcagaacgc cggacgcagc cgcttccccc
    10921 cgcgcagcag cgcgtccagc gccccgagca gcggcgacag gtcgtcgctg atggccagca
    10981 ggcccgggcg ctgccgatcg acgaaggcga gcagcgcctc gtcgacctcc ttgcggatgc
    11041 ggctggtcga catgtcgtga tcgtatccag gggaaggcat tcaaccgccc gtcgttagcg
    11101 cgagatgtcc atcgatccta ggaaatccct gcatattcgg gacaacgggg tatatgttcc
    11161 cagcccggcg gggtgcgggc cggatccggc ccgcacccgg gccccaccgc ccaccccttc
    11221 tgtacgctgg tgggatgcga cccgtacgcc ccgaccggcc ccccacagtc cgtgaactgc
    11281 tcgccaccgg tggaaggtcc ttctccttcg agttcttccc gcccaagacc gagaagggcg
    11341 cgcggaccct ctggcgtacc atccgcgagc tcgaacccct ccagcccacg ttcgtctccg
    11401 tgacctacgg cgcgggcggc ggcacccgcg acaccaccgt cgacatcgtc gaacggatcg
    11461 ccaccgacac caccctcacc ccggtcgccc acttctgcgc ggtgaaccac tcccaggccg
    11521 agctccgcca cctcatcgga cggctcgccg ccgcgggcgt ccgcaacatg ctcgcgctgc
    11581 gcggcgaccc gcccggcgac ccgatggggg agtggatcag ccaccccgac ggcgtcgagt
    11641 acgccgccga cctcgtccgc ctcatccgcg ccaccggcga cttcagcgtc ggcgtcgccg
    11701 cgttccccta caagcacccg cgctcgcccg acatcgagag cgacacccgg tacttcatcg
    11761 agaagtgccg cgcgggcgcc gactacgcca tcacccagat gttcttccgc gccgaggact
    11821 acttccggct gcgcgaccgc gtcgccgccg ccgggtgcga cgtcccgatc atccccggga
    11881 tcatgcccgt cacccagctg agcaccatcg agcggtccga gcagctgtcg ggcgcgccgt
    11941 tcccgcccga ggtcaaggcc cggttcgacg ccgtcgccga cgaccccgag gccgtccggc
    12001 ggctcggcat cgagcacgcc gccgaactct gccgcgacct gctcgaccag ggcgcgcccg
    12061 gaatccactt catcacgttc aacaagtcga cggcgacccg cgaggtgtac gggctgctcg
    12121 aggccgacgg ctactgcggg acgtccgcgc ccgcggccga gccggtggcc agcggcagcg
    12181 tcccgcccat gaccgcgtag cggggcccgc cgccggggaa ctcgaaatcg gtcagcaggt
    12241 cgaccatgcc gaccgagcgg tagagccggc gggcgggggt gtccgggcgg cgctccagcg
    12301 tcgacagcac caccgtccgc tccggcctgc cctcgcacag cgcggccagc agcccccggc
    12361 cgagcccccg gccctgcgcg tccggacgga cgtgcagctc ggcgacctcg aacgcgtcct
    12421 ccagccacgc cgccgcgtgc tccgggccgc cccgcgcggt gagcgcctcg atgacgacgt
    12481 cgtgccacca ctggccgcgg gcaccgtgga acccgtacgc gaacccgtgg agcggccccg
    12541 gcaggcgcgc cagcgcaccc cggcgctccg cggcgaacgc ccggaacccc gggtaccccg
    12601 cgtgccgctc catgatcatg cggcggcccg gcagctgctc cgccggcggc gacatcgccg
    12661 ccgcgtagac gtccagcatc ggggccaccc tgcgcaggaa ggcgcgttca tcgatctcgc
    12721 gcagcttcgc gtccctcacc cgcccgagcc tagccccggg gaagggtccg gggggtcgcg
    12781 gacagccgat cgtagatgtc ccacaggatc cggtcggccg cctgccgcag ccgcgcccgc
    12841 tccgcgtcga gcgccgaacc ccaccggcgc gcctccgggc cgagccacgc gtccgtcccg
    12901 cccagggtct tcacgggcgc gtccagcgcc tgccggagcc ggtcgatccc gccgtaggcg
    12961 tccgcgtacg cccggtagag ctgcgcgtag gccgggttgg ggcgttccgt cagcggcagg
    13021 gcggcggcgg ccgcgccctc gagcggcggc ggcaggctcc ccggcggcgg cgcgctcacg
    13081 ggtcccgcct cggcgccgcc ggatcctgct ccgacgtcgc cagatccagc ttcccgaccg
    13141 cctcctgtgt gcgcgcgctc cagtccacgc ccgtcaggac ctggacggcc accggacgca
    13201 cgccgacgcg ctccgcctcg gccaggaacg cccgcagcca cgcgacgtcc atgcggacct
    13261 cgttgctcgc catgcccagc gactcgcgga tcacccgcag ccgcgccgcg tcgccctcgc
    13321 ccgccgcgag cagccgcgcg gtgcccgccg ggcccagccg ctcgtacagg cgcgcggtgt
    13381 agtcgggatc gtcggcgtcg gccttcaggc gcgtccagac ggcggccggg acggccgcgc
    13441 cgtcctcgaa cgccgcccgc agcgcccgcg cgtcggcctc cgccgccttc tcggccgccc
    13501 gccggtccgg atggctcccg atgtcgcccg cgccccgcga ggagagaccg ccgcccgccg
    13561 ggggcgcctt cgcccgtccc ggatcggggg tgcgcggggc ctgcgccacc gggtcccggc
    13621 ggggcggcgc caccggcgcg ggcgcggcgc cgcccgcctc caccggcgcc cgccccgcct
    13681 ccggcgacgg cgccggggac ggcggcgcct gcatggaacc gccgtccggg tgcgtgatcg
    13741 cgtagttgta gcgccgcgac agcatcccga gctggctccc gacccactgc gcgacctcgt
    13801 cggcctgccg gtaccccgcc gccgacactc ccggcggcgg gcggtgcccg ttcagccagc
    13861 cgcggatcgc cgtctgcgcg tcccgcatct gcgtgatgag ccgatcgagc gcgggcgggt
    13921 cgatcccccg gaagttcgga tcgcgggcgg ccgggcccgt gcgcatctgc gcggtcactg
    13981 gtcctccggg ggtcgccgga cgtcggtcgt acccagaatc acaccggcgt tacaggctgt
    14041 cgagggcttt gcggacggag tcctcgtccc gcgcgacgat cgccgcggtg ccggtcacca
    14101 cgatcggccg ctggatcagc accgggttgg ccaccatgac ctcgatccac cgcgcccggt
    14161 cgcgctcgag ctccttcagc ccgagatcct tcgcgacggc ctcgcccagc cgcgcgacct
    14221 cccacggctc cgcgccgatc cgggtgagca ccgcgtccag ctcgtccgcc gtgggcgggt
    14281 cgtccaggta gcgccgctcg gtgtagtccg cgcccgcctc gtccagcgcg gccttcgcgg
    14341 cgcggctctt ggagcagcgc gggttgtgcc agatctccgt catcactcca cctccgccgg
    14401 gtcgcccccg gtgatcttca gcagctcctc gtacgacgtc gggaacaccg tgtgcgggtg
    14461 cccggccgcc gcccacaccc ggtcgtgccc gccgagccac acgtccacga gggtgcggat
    14521 cggcgccgga tggcccaccg gcgcgacacc cccgatcggc tgcccggtcg cctcccggac
    14581 gaactccggc gtcgcccgcc gcacccgccg cgcgcccacg agcccggcga ccttcgcggt
    14641 gtcgacgcgg tgcgcaccgc tcgtcagcac cagcagcggc gcgccgtccg cgtcgaacac
    14701 caggctgttg gcgatcgcgc cgaccgcgca cccgacctga tcggcggcgg cccgcgccgt
    14761 cggcgccgaa tcgggcagtt cgacgatctc gccctccacc ccgtgacctt gcaggacgct
    14821 cgcgacgtgt tcggcgttcg gatgcatgcc cgcaccctag ccgacctgct cacgccgatc
    14881 cgttcgaaca cgttgacgaa tcgtcaccgg gcgggtttac tgtgaatgcg tcgaacttat
    14941 gttcgacgtg atgcgggact cgcggcccgt atcagggcga cgcccccgcc ggtgccgatg
    15001 cgccggcggg ggccgagggc cgggcggagt gaggggaagc tctccgcccg gccggcccga
    15061 gccccggaag gaggcagcca tgtccgcaac cgccgttcac tccgccgcac tgtccggccc
    15121 gccgagcccg cggcgccgtc cgaggcccgc gccccgtccg gcgcacaccg cggtcggcca
    15181 gttgcaggcc gcccgcaccg gcctcgccga agccgcggag gcgaccacgc ccgccgtccg
    15241 ctacgtctgc gcgcatctcg ccgcgcttcg cgccgccgcc gccgtgctgg cctcccgcga
    15301 acccgtcgag acgcaccacc gcggccgtcc ccgcagcgtg tgggtgctgc tgcccgaggc
    15361 cgagcccgcc ctgcgcgagt gggccgcctt cttcgccgcc ggtgccgaca agcgcgccgc
    15421 cgccgaggcc ggcctgcccc gcgccgtcac cgtccgcgag gccgaggaac tcctgcacga
    15481 cgcggagatc ttcgtctccc tcgtcgagga ctgcctcggc atcgccggcc agaccgccct
    15541 cccgttcacc gacgcgaact gaccgcaccg acgccgccga ccctccccga ggggccgtcc
    15601 caccctcccc gggaccgccc cgcgccgggc cggggcggac cgctcccctc accgagcacc
    15661 gccccggccc cgcgccgcgg agcggaggtg gcgggcgcgg cggggatatg ggcgggtgat
    15721 agggatttgc ggatggacgc actgttgccg ctcgccggga tgcggatcgt cgagatctcc
    15781 agcttcgtcg ccgcgccgct cggcggcatg acgctcgcgc agctcggcgc cgaggtgatc
    15841 cgggtggacc agatcggcgg cgggcccgac atcgaccggt ggccgctggc gccgtccggg
    15901 cggagcctgt actgggcggg actcaacaag gggaagcggt cggtgaccgt cgacctgcgg
    15961 tcggcggagg gacgcggtgt cgcggcgcgg ctggcggcgg agtgcgggac cgtgctgacg
    16021 aacgccccgc cgcgcggcgg gctcgccccc gccgagctcg cggcgctgcg gcccgacctc
    16081 gtgcacgtcc agctcgtcgg gcgccgggac ggcggcaccg ccgtcgacta caccgtgaac
    16141 gcggcgtccg ggttcccggc gatcaccgga cgggacggcg caccggtcaa ccacgccctg
    16201 ccggtctggg acgtcgtgtg cgggctctac ctggcggccg ggctcctcgc ggcggagcgg
    16261 caccggctgc ggacgggcga ggggagcggc ctgcgggtcg cgctggacga catcgccctg
    16321 gccactgcgg gcaacctcgg gtacctcgcg gaggcgcagc tcgggacgcc gcgcgaacgg
    16381 atcggcaacc acctcttcgg ggagttcggg cgcgacttcg cgacggcgga cgggcgcgtc
    16441 atggtcgccg tggtcaccgg acggcagtgg cgcgacctcg tcgccgcgac cgggctcggg
    16501 gaggtcgtcg aggcgctcga gcgggcgctg cgggcggact tcgggacggc cggggaccgg
    16561 taccggcacc gggaggcgat cggcggcctc ctcgcctcct ggttcgggac gcgcacgtgc
    16621 gcggagatcg aggccgggct gcacggcacg tccgtcctgt ggtcgcggta ccgggacttc
    16681 ggggaggtcg cgcgggaact ggacgggcgg ccgctcatgg ccgagatcga ccagcccggc
    16741 gtcggccccc acctcgcgcc gggctcaccg ctggtgttcg gcgggcaggc gccgcccggc
    16801 cccgcgcccg tcctcggcga ggacaccgcc ggggtcctgc gggacgtgct cgggctctcc
    16861 ggcgatgccg tggacgatct gcgcgcccgc ggagtcgccg gagagccctg acggcgggcc
    16921 tcgcggacgc tcgcgcctcg cggcgtgacc ggccgccgtc cgcgtgcgcg ggtcaggcct
    16981 cctgcaggac ggagaggacg ttgcccgccg ggtccctgaa ccaggcgatg agcggaccca
    17041 tctcgcgcat gatccctttc gcgtcggtgt agccgtcgta ctgctcgaag gcgacgccgc
    17101 gctcgccgag ttcgtcgacg gcccgctcga tgtcgtccac cgggaagttg aggatggtga
    17161 acgtcgccgg cgtgtggtcg ggcttcgggt agacgagcgt gtcccggtcg cccgcgatgt
    17221 gcagggtgag catgccgtgg tcctcggata ctccgaggcc caagacctct ccgtagaact
    17281 cccgcgcggc ctcgatgtcg tcgaccgaga agccgctgta cgccttcgtg tccttgaaca
    17341 tgtgtcgcct cccgctcatg tgcgcgcgtc tcgtgctcac cggtaccgac cgggcccgtg
    17401 cccggaactc atcgcatggc ttttgtgggc atatgagatt gttagtaggg cgaagtaagg
    17461 gggacggacg tggcggcgcg cggcggtcgg gggctggtgc cgctgctggc gttcctcggt
    17521 gtgtcggcct actcgctgtc gatggcggtc gtcaccccgg cgctgccgca gatccaggcg
    17581 ggcctgggca cgacgccggc cggggcggcg tgggcgctga cggcgatgac gctgtcggcg
    17641 gccgtggcga cgccggtggt cgggcggctc ggcgacctgt acgggccccg gcgggtactg
    17701 ctgtcggtgc tcgcggcggc gacggccggg atggtcgtgg ccgcctcggc cgggtcgctg
    17761 ccggtcatgc tcgccgggcg ggtcctgagc ggggtcggcg cgggggtgtt cccgctcgcg
    17821 tacacgatca tccgggacgt ggttccggcc gggcggacgg cgtcggccgt ggggctgatg
    17881 tcgtcgatgc tggggctcgg cggcgcgctg tcctggtgca tggcgggtcc gatcatcgac
    17941 ctgctcggct ggcgctggct gctgtgggtg ccggtgctcg ggctggtgcc ggggctcgcg
    18001 gcggcgtggt ggatcgtgcc gcggtcgccg tcccgcgccg gcgcccgggt ggactggtgg
    18061 ggcgcggtgc tgttcgcggg gtggctggtg gcggcgctgg cggcgctcac ccaggggacg
    18121 ttctggggct ggacgtcacc gggcgtgctg gggctgctcg cggccgcggt ggtgacggcc
    18181 gcgatctggc tgtgggtcga gacgcgcgtg cgcgaacccc tcgtggaccc gcgcgtcatg
    18241 cggctgcgag gggtgtggac ggccaacgcg gcgtcgctgc tgtcggggta cgcgctgatg
    18301 gcgggcgggc tgctgttccc gctgctggtc cagctgccgg aggacaccgg gtacgggttc
    18361 gggggcagcg cgacgcaggc ggcggtgctg cagttgcccg cgagcatcgg gatgaccgtc
    18421 gcgggcgtgg cggcgggggc gctggaccgg cggttcgggt cgcgggcggt gctgtccggc
    18481 ggggcggtgc tgacgtgcgc cgggtacgcg ttcgtcacgt tcgcgcattc ggagctgtgg
    18541 cacctgtacg tcggcgggct cgcccggggg atcgggctcg ggctcgccta cgcggcggtc
    18601 gcgacgctgg tggtgctggc ggttccggtg ggggatacgg gcgcggcgac gggcgtcaac
    18661 acgctgatcc ggacggtcgg cgcgtcgctg ggcacgcagg tcagcgccgt gatcgtggcg
    18721 ggcatgccgg gggagcgggg gttcaccgcc gggttcgcga tgagcgcggc ggcgatggcg
    18781 gccgtgctgc cgctggcgct gctggcggcg cgcggcgggg gacgggcccg gggcgccggc
    18841 ggggagccgg tggtgcgccc gtccatcacc acggcggacg cgcgcgacgg cgcgtgaggc
    18901 ggctcagttc cggggccgga acccgtcgaa cacgacggcc agcgcgcggt cgcgcgtccc
    18961 ggcgtcccac cggccccgct cggccgccag gcaggcggcg ccgagcagcg cgagcacctc
    19021 cggcattccc acgtcggcgc ggacgtcgcc ggaccgctgc gcgccggcca ggagggtcgc
    19081 cagcgagtcc ttgatctccg cggccaggtc cgccatcccg gccttcacgt cggcctcggc
    19141 gacgccggcg tcggtgagcg cgtcgaccag catcttcttg tgggtgctgt cctcgacgat
    19201 cagggtgaag aaggtgaaga acgccgcccc cggcgcggtg ccgcccgacc cggcgatcag
    19261 ggccgcggcc tcgtcggcga gggcgccgat gcggtcgcgc acgaccgccg cgaagaggtc
    19321 ctccttggtc gggaactgcc ggtagatggt ggcgagcccg acgccggcct cgcgggcgat
    19381 ctcgcgcagt gaggccgacg acccgtcccg cgccaggacg gtccgcgccg cctccaggac
    19441 gcgcgcgcgg ttgcggcggg cgtcggcgcg cagcggacgg ccgggttcgg gcatggcggt
    19501 tcctcgctcc ttgctaaccg gatcaggtgt tccgtatagt tccggaacgg aaccggatca
    19561 aatgttccgg ttccgtggct tccgctgatt gtaacgaggg gaccggcatg gagtacgcga
    19621 cgctgggacg gtccgggctc aaggtctcgc aggcctgcct gggcacgatg aacttcggca
    19681 ccgaccatcc gttcgccggc tgcacggagg acgaggcccg ccgggtcgtc gacgccttcc
    19741 tggacgccgg cggcaacgtc atcgacaccg ccgacgccta caccggcggc cagtcggagg
    19801 agatcgtcgg acgggcggtc gcgggccgcc gggactcggt cgtgctcgcg accaaggcgt
    19861 tcatgcccca gggggacgga ccgaacgaca tcggcctgtc gcgggcgcac ctcacgcggg
    19921 cgctcgaggc cagcctgcgc cgcctgggaa cggaccacat cgacctctac cagtgccacc
    19981 agtgggacgc ggcgacgccg atcgaggaga ccatggcgac cctggacggc ttcgtccggt
    20041 cgggcaaggt ccgctacatc gggtgctcga acttcaccgc cgcgcagatc gtcgaggcgc
    20101 gccgggccgc cgagcgggcc ggcggaacgc cgttcgtcag cctgcagccg cagtactcgc
    20161 tggtggcgcg cgccatcgag gcggagatcc tgccggcgtg cgagcggcac gggctgggca
    20221 cgctgacgta ctcgccgctc gcgaacgggg tgctgaccgg acggtacgcg cgcggtgcgg
    20281 cgccggccga ctcacggatc gggcggctgc gctcgtcccc gctggacatg gcgcgcaggt
    20341 acgccggcga catgctgaac gagcggacgc tgggcatcgc ggcggaggtc ggtgccgtcg
    20401 cggcggagtt gggcgccgcc tccgccgccg tcgcgctcgc ctgggtgcgc gcccgtcccg
    20461 gggtgacgtc ggtgatcgtg gggccgcgcg acctggagca gctgcgcggg aacctggcgg
    20521 gcttcgcgct ggagttgccg gacgaggcgg ccgcccggtt ggacgaggtg tcgcgggcca
    20581 ccgtgctgcc gcccgtcacg gggatgcagg tccggcacca cgccgaggtc gcgcgcgcgt
    20641 cctgacccgc cgggcgcgcg aacgggggcc cggccggagc cgggcccccg tgtcgctgtg
    20701 cccgtgtcgc tatgcccgtc tcacgatgcg cgcgacggga gcgggcgcgt cagaacgact
    20761 cgacggcgcg gcgcgcctcc gggtcgagga cgccccagga gatcagctcc tcggtcagct
    20821 ccgtcgggga cttgtcgtag atgaccgcga gtgaacgcag gtcctcctga cggatcgaca
    20881 aaacctttcc gttgtagtcg ccccgctggc tctgaatcgt cgcggcgtaa cgggcgagag
    20941 gaccggcctt gtccttcgga agctgctgca gccgctcgag gtcgatcacg agcttgggtg
    21001 taggcccgag cgggctcggc gcggcaccgc cgggcagcaa ctcggaaacc ggc
//
