LOCUS       NZ_CP044407            26463 bp    DNA     circular CON 28-JUL-2024
DEFINITION  Actinomadura sp. WMMB 499 strain WMMB499 chromosome, complete
            genome.
ACCESSION   NZ_CP044407
VERSION     NZ_CP044407.1
KEYWORDS    RefSeq.
SOURCE      Actinomadura sp. WMMB 499
  ORGANISM  Actinomadura sp. WMMB 499
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Thermomonosporaceae; Actinomadura.
REFERENCE   1  (bases 1 to 9187113)
  AUTHORS   Braun,D., Bugni,T.S., Chevrette,M.G. and Currie,C.R.
  TITLE     Draft genome of Actinomadura sp. WMMB499
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9187113)
  AUTHORS   Braun,D., Bugni,T.S., Chevrette,M.G. and Currie,C.R.
  TITLE     Direct Submission
  JOURNAL   Submitted (26-SEP-2019) Pharmacy, University of Wisconsin-Madison,
            777 Highland Ave., Madison, WI 53705, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Canu v. Oct-2016
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 300.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_008824145.1-RS_2024_07_28
            Annotation Date                   :: 07/28/2024 05:00:58
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,523
            CDSs (total)                      :: 8,413
            Genes (coding)                    :: 8,251
            CDSs (with protein)               :: 8,251
            Genes (RNA)                       :: 110
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 92
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 162
            CDSs (without protein)            :: 162
            Pseudo Genes (ambiguous residues) :: 0 of 162
            Pseudo Genes (frameshifted)       :: 64 of 162
            Pseudo Genes (incomplete)         :: 108 of 162
            Pseudo Genes (internal stop)      :: 10 of 162
            Pseudo Genes (multiple problems)  :: 19 of 162
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 04:12:41
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4288508
            Orig. end                         :: 4314971
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP044407.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Genome not circularized.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..26463
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="12"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..26463
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..26463
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:16463](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..16463
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    121..131
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     gene            353..856
                     /locus_tag="F7P10_RS18870"
                     /old_locus_tag="F7P10_18870"
     CDS             353..856
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="F7P10_RS18870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="F7P10_18870"
                     /product="hypothetical protein"
                     /protein_id="WP_151010577.1"
                     /transl_table=11
                     /translation="MAGIRMPDERQLPLGPHRDLVAAVHDLYELAGKPAARTISAWIRD
                     QDDLPGTLSHEGVSAVLRGASMPRWANLESLVRVLVEQQRVGQSDAEVTLARIHAFWHM
                     ADGGMARKPHEGQDSESQPPDSQLPAHETIARWDHPRLGVVEFRDRQAFIEIFREVGGF
                     SDEP"
     gene            843..>1031
                     /locus_tag="F7P10_RS45460"
                     /pseudo=""
     CDS             843..>1031
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024767.4"
                     /locus_tag="F7P10_RS45460"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTNRNRADSGWSRFEQSGSLNDLNAAITAAREAAELVPEDHRDRA
                     AVLNNLGSALRARFERTR"
     gene            1137..2198
                     /locus_tag="F7P10_RS18875"
                     /old_locus_tag="F7P10_18875"
     CDS             1137..2198
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1272: TPR
                     repeat-containing protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF024816.4"
                     /locus_tag="F7P10_RS18875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_18875"
                     /product="tetratricopeptide repeat protein"
                     /protein_id="WP_176611896.1"
                     /transl_table=11
                     /translation="MLSAAGRISEALEVAQEAVEIRRALAAQDPDTYLSDMASSLSNLG
                     NRLSAAGRIWEALEVAQEAVEIRRALAAQDPEAYEAHLAGALSNLAGFYLSAGDVMRAI
                     PLLDQTLADYERMLGGDHPHTLTTRNNLAYAYQAAGDLGRAIPLYEQTLDDRGRVLGGD
                     HPDTLASRNNLAYAYQAVGDLGRAIPLYEQTLNDRGRVLGTDHPNTLTSRNNLAYAYQA
                     TGDLSRAIPLYEQTLNDSERVLGTDHPNTLTSRNNLAGAYQATGDLSRAIPLLEQTLND
                     YERVLGSDHPDTLTSRNNLAGAYQAVGDLRRAIPLYEQTLNDSERVLGPDHPTTQTVQR
                     NLSAARGEDPDGK"
     misc_feature    2800..2815
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 21.79"
                     /tool="antismash"
     gene            3062..4183
                     /locus_tag="F7P10_RS18880"
                     /old_locus_tag="F7P10_18880"
     CDS             3062..4183
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1077: phage integrase
                     family protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017607020.1"
                     /locus_tag="F7P10_RS18880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_18880"
                     /product="tyrosine-type recombinase/integrase"
                     /protein_id="WP_151010581.1"
                     /transl_table=11
                     /translation="MRGEVPGAARLRLVDGVPLLRPEEQVFTAMLDGWRNQQLARNLSF
                     GTIESRQRAVRAFAHSADALPWVWTPQLVDEWMGDLRSVRDLKRSTLRNYQDALRSFCH
                     YLTDPAYGWAAECEDRFGTHPIQVVHEWNSAVHVQEAEAEPTKRAFTLEEIQAFLDYAD
                     DQVTAVRGRGRKGWLPAFRDATLFKVAYGYGLRRRETRMLDPVDFGRNPQAPEFGDHGV
                     CCIRYGKAKPGSPPKRRSVLTVWGWIVEAADQWETEVRPRFSTATAGTYWPSERGPRVG
                     YSQINTRFAIYRDALGLDPALDFHSFRRSYVTHLIEAGWDARFVQEQVGHEHASTTSIY
                     TCVSSDFRTRTLRRALDATLDAALRPDRAGSSR"
     gene            4180..4512
                     /locus_tag="F7P10_RS18885"
                     /old_locus_tag="F7P10_18885"
     CDS             4180..4512
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017607021.1"
                     /locus_tag="F7P10_RS18885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_18885"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_151010583.1"
                     /transl_table=11
                     /translation="MKRQVGYQWRLREVMAESGMFDTTDLIPLLADRGIKLSSVQVWRL
                     VTQTPERLSLPVLAALCDIFSCGPERLIATKAENTTARKTAGHGPEVVDLAEVVRPKRA
                     RIRPDQ"
     gene            4509..5786
                     /locus_tag="F7P10_RS18890"
                     /old_locus_tag="F7P10_18890"
     CDS             4509..5786
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="F7P10_RS18890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="F7P10_18890"
                     /product="hypothetical protein"
                     /protein_id="WP_151010585.1"
                     /transl_table=11
                     /translation="MTTLTCGGCGAPGRRYRNGLCQPCVLTADLRAVLDDGAGGIRPEL
                     LPFFDALRTMTKPIAGISWIRRPHVDAMLRTLADPATALTHQTLDSMTPWRSVTYLRDL
                     LMLHGVLPAADRHLLLFQRWLRAVLDEITDPGQRQLVARFAAWHVLNRLRRFAARGPLS
                     QTQTNQARDQARDQARDQVRSAIAFLTWLETRDKNLADCRQADIDAWYADGYTRRRNTH
                     PFLRWAMNDKALPTVTIPHQPTANPAPLSQQRRLQLLHHFLTDDQIPLLTRVAAVIVLL
                     YAQPVTRILRLTIDDVIRDGPAVSLQLGDPPSPVPEPFASLLLAYLDQRLNLTTATNSG
                     SRWLFPGRRGGQPMTSDAITRRFRDQGINSISGRTSALRYLVLQAPAPVISRMLGYTDQ
                     QTSRTTADAGTPWSRYAPDDHHRWDA"
     gene            complement(5783..6253)
                     /locus_tag="F7P10_RS18895"
                     /old_locus_tag="F7P10_18895"
     CDS             complement(5783..6253)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025451.4"
                     /locus_tag="F7P10_RS18895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_18895"
                     /product="DUF4265 domain-containing protein"
                     /protein_id="WP_176611541.1"
                     /transl_table=11
                     /translation="MQFIVHEHPVGRAAQNYLAHVDLERFGLAGQREQLWLRPCQGGDY
                     VVACLPFRVYGLALNDRVRLSEDGATVVELLERSGHRVLRVLFTPRSDQDAFMARITGE
                     VEIAGLAFEWSGKRHLAVDVPQDASPVRLFGVLQEEIDAQQAYWEWADVEAF"
     gene            complement(6417..6623)
                     /locus_tag="F7P10_RS18900"
                     /old_locus_tag="F7P10_18900"
     CDS             complement(6417..6623)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019631751.1"
                     /locus_tag="F7P10_RS18900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_18900"
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_176611898.1"
                     /transl_table=11
                     /translation="MINSGAPSSPVWRKSSRSGGGNQCVEVARISDARAIRDSRNPEGG
                     HVALRANAYGTLVSRIKNGEFDL"
     gene            complement(6640..7206)
                     /locus_tag="F7P10_RS18905"
                     /old_locus_tag="F7P10_18905"
     CDS             complement(6640..7206)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040183.3"
                     /locus_tag="F7P10_RS18905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_18905"
                     /product="DUF5753 domain-containing protein"
                     /protein_id="WP_151010589.1"
                     /transl_table=11
                     /translation="MFTGSYVGLESAAARIRINAQLVPGFLQTEEYARAVIGRTRPTLE
                     AGEVDRRVAARAARREALFGKEEPPEVHVVLDESAIRRRIGGRDVMRGQLASLIEAGAL
                     PNVTLQVLPFAFGAHAGVEGEFVILTFHEPEDSPVVYAEGLMGDLYLESEPELDTYQLA
                     WTYMLEGALDPRESVAMLRELHDQL"
     gene            complement(7260..7442)
                     /locus_tag="F7P10_RS42445"
     CDS             complement(7260..7442)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024949.4"
                     /locus_tag="F7P10_RS42445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_176611542.1"
                     /transl_table=11
                     /translation="MRELKRLREAAGLSLEVAAKRLDFSKSKLYRLENGRSRVSTDDLE
                     DMLDLYDVWSRSARR"
     gene            7860..8342
                     /locus_tag="F7P10_RS18915"
                     /old_locus_tag="F7P10_18915"
     CDS             7860..8342
                     /EC_number="2.7.13.3"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024970.4"
                     /locus_tag="F7P10_RS18915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_18915"
                     /product="ATP-binding protein"
                     /protein_id="WP_176611543.1"
                     /transl_table=11
                     /translation="MNAPPLCEPSAAPDEPERTLVRRLDGPQPEHRARSVLSEVLARLG
                     LTDEAFEAELAVNELVTNARQHAPPPYEIRISWTEMRVTIAVVDGGIDHGAVLKLLSRA
                     TTGCPSEGESGRGLQMVAGLFGGRCGAGATRMSSGLVPAKQVWIVLPRQRSEVVVR"
     gene            8354..8584
                     /locus_tag="F7P10_RS18920"
                     /old_locus_tag="F7P10_18920"
     CDS             8354..8584
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="F7P10_RS18920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="F7P10_18920"
                     /product="hypothetical protein"
                     /protein_id="WP_151010596.1"
                     /transl_table=11
                     /translation="MSEDEREAIRLAGDFRSRIQRWLDQREIQGPLIALPCVGIDGKPN
                     VEARTGGRIARTLAMGLGERSHPPPPSTWRT"
     gene            8846..9658
                     /locus_tag="F7P10_RS18925"
                     /old_locus_tag="F7P10_18925"
     CDS             8846..9658
                     /EC_number="2.1.1.-"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1292: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019634279.1"
                     /locus_tag="F7P10_RS18925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_18925"
                     /product="SAM-dependent methyltransferase"
                     /protein_id="WP_254716697.1"
                     /transl_table=11
                     /translation="MAAESLNQASNVIDPAVATASGMYDYYLGGTDNFAGDRRAAHRVI
                     AEAPEVLLLARENRRFLQRAVRFLARDAGMRQFLDIGTGLPTQGNVHEIAQREAADARV
                     VYVDNDPKVLAHSRALKTTEAGATSVVTADLRDPQSILGHAETRRLIDFDQPVAILLVA
                     VLHFISNDSDPYGIVRRLCAAMAPGSYLAISHVTADPRPEQANGLRKVYRSTANPVTHR
                     TRSQVDRFFDELEYVDPGLVYVPAWRPDGVSDVAPEEVWILGGVGQKQ"
     misc_feature    9720..9734
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 17.52"
                     /tool="antismash"
     gene            9725..9901
                     /locus_tag="F7P10_RS18930"
                     /old_locus_tag="F7P10_18930"
     CDS             9725..9901
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017573280.1"
                     /locus_tag="F7P10_RS18930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_18930"
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_151010598.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 1.6e-11, bitscore:
                     42.9, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLRNSTVEPEAVAGPTDAAPDAFELDVRLLEIADPAGLVNVTDDG
                     CTSTCGACISNAY"
     CDS_motif       9725..9832
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MLRNSTVEPEAVAGPTDAAPDAFELDVRLLEIADPA"
                     /locus_tag="F7P10_RS18930_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9833..9901
                     /prepeptide="core"
                     /locus_tag="F7P10_RS18930_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="-8.30"
                     /molecular_weight="2074.3"
                     /monoisotopic_mass="2072.9"
                     /core_sequence="GLVNVTDDGCTSTCGACISNAY"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MLRNSTVEPEAVAGPTDAAPDAFELDVRLLEIADPA"
                     /leader_location="[9724:9832](+)"
                     /alternative_weights="2092.3"
                     /alternative_weights="2110.3"
     misc_feature    complement(9983..9997)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.6"
                     /tool="antismash"
     gene            10001..13108
                     /locus_tag="F7P10_RS18935"
                     /old_locus_tag="F7P10_18935"
     CDS             10001..13108
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.4"
                     /locus_tag="F7P10_RS18935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_18935"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_218040571.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 3e-196, bitscore:
                     652.3, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 3.4e-20,
                     bitscore: 71.5, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 2.6e-18, bitscore:
                     65.5, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPPSARPQKFKSVGAALFRAAAHSSEGLPPYPDLTGEATPARVVT
                     WVDWLRQVWTNETVVDALEHASPSLARQVRAVCDAPAPAPRETRRAVLSVVRYLQRMTG
                     RATPFGLLAGVAPASFGAEPLFRWGPRHRAATRAGAGWLAGVIERLEGCSELLACLPVA
                     ANNTLFVRGDRLIVPYRPWKRARGAGAVEISVRHTDAVRAAVEAARDPIRIEDLAAKIR
                     GDFPAASPAQVATMLTELVARGVLISSLHAPSTEPDALRYLVTELAAAGASAVAPVTGL
                     AGELRKIHTLTGHHDLAGPSAAKVMRADVCELMRLLSPSEQHPMAIDLRLDAAVVLPHD
                     VAREVERAALVLARTSAFPVGTPAWRAYHQRFYERYGIGSLVPLLDVVSDSGVGWPDGY
                     PGTVTPERRSPMSARDRALLAIAQQAALDRCEEVVLDDRLIESLELSSEPLRPPSHLEL
                     GVRVRATDRRALRRGRFTVEVVSVSRGAGVSCGRFLSVLTERERAAFVGGLADLPGGDR
                     GTVGAQLSFPPLDPATAHVTRVPKLLPTVISLAEHRHDARTALAPEDLAVGCDGRRLYL
                     ADPAHGRRLEAFGMHALNLVTHTPPLARFLTELGRAQCAQVTTFDWGAAAGLLFLPRLR
                     FGRTILSPARWRLEARELPARAQPWAAWDAAFDEWRTRRRISRLVNLAEGDQLLPLDLD
                     RTAHRVLLRTHLDGAPEAVLTEAPAPDDASWCDGRPHEVIVPLVATEPPPWPPLPEPTS
                     ARVVHEDRSETPAISRVLLASLYGDVHRQDIVLTEHLPVLLRRLDEPAWWFVRYRDPAH
                     HLRLRLVLPEPDAFGDAARTVSAWVDELRRVGLLREVTYPTSWPETGRWGAGVAWTAAR
                     AVFAADSQASLVQLGTAPRPHPHALVAAQAVAIAVGFTGGVAEGMRWLVEHVPAGAPAR
                     VPRPVFEGAVRIADPSGGWAALRAAPGGAPIARAWQPRDRALAEYRPHFPGPHTEGIAF
                     DDVLASLMHVNFVRTGGIDFDEEAIGLYLARAAALSWTARATGGHR"
     aSDomain        10484..10759
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_F7P10_RS18935_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="1.10E-22"
                     /identifier="RREFam001.1"
                     /label="F7P10_RS18935"
                     /locus_tag="F7P10_RS18935"
                     /protein_end="253"
                     /protein_start="161"
                     /score="71.5"
                     /tool="antismash"
                     /translation="VAANNTLFVRGDRLIVPYRPWKRARGAGAVEISVRHTDAVRAAVE
                     AARDPIRIEDLAAKIRGDFPAASPAQVATMLTELVARGVLISSLHAP"
     gene            13105..14382
                     /locus_tag="F7P10_RS18940"
                     /old_locus_tag="F7P10_18940"
     CDS             13105..14382
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.4"
                     /locus_tag="F7P10_RS18940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_18940"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_151010600.1"
                     /sec_met_domain="LANC_like (E-value: 1.2e-44, bitscore:
                     151.4, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNDEHPARELGDAIAELLAHPDGLPARLTSRPWWRQSLAHGAPGI
                     ALLHIERAAAGLSPWRRAHDWLAYATQAPLTTGFDSHLFYGAPAVAHALACAADLLPGS
                     YTGALDHLDRVIAADVRRRASSALGWLEAGHLPSLSEFDLVRGLTGIGSYLLRRAPGSE
                     ATRAVLEYLVRLTEPTRDGEESLPGWWTLSGPDGHEHDHFKGGHANSGLAHGIGGPLAL
                     LALASRRDVVVDRHLDAISRICTWLDRWRTDTPSGPIWPYWVNRPQQRADQRSVSGSQR
                     PSWCYGTAGLARAQQLAALATGDTERRDMAERALMQALTDPAQRSSTTDPTLCHGYAGL
                     AHIAARVAADAAPDTAEGLHALIPDLLDSIHTVSTDPGRTAVALLGDRGCGPAFLEGGA
                     GIALAVLTPTGTGIPRSGWDTCLLVA"
     misc_feature    13768..13770
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            14403..16463
                     /gene="fxlM"
                     /locus_tag="F7P10_RS18945"
                     /old_locus_tag="F7P10_18945"
     CDS             14403..16463
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR04364.1"
                     /locus_tag="F7P10_RS18945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_18945"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_176611544.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.7e-30, bitscore:
                     105.6, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PCMT (E-value: 6.2e-42, bitscore: 142.7,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPDLEWRQYNIYFPDRRTAGAVAAHDLRPALVAAQEAGVLHGWWF
                     MRKHPWRLRYIPRVAGSSAVAELLDDLAATGRIKAWTPGIYEPETAAFGGNTAMAIAHT
                     LFHHDSRHVLARAAQCSVPPLGLRETTALLCNAMFRAAGLDWYEQGDVWSKVAALRPVA
                     PAASRPQQQRAAHRLMTVDIHDLCGSGPLGGYEGWISAFEQAGRALAALAHEGFLTRGL
                     RAVLAHHVVFHFNRASLPVTDQAALAAVLSDTVFQSVPNSPTTSTTTIKVQPMTTLSDN
                     RAASADELRAELADRLRDRNVLNSPAIEEAFRRTPRHLFLPGVPLDRAYADTPVYTKTE
                     DGGEHISAASQPGIVTMMLEQLDPRPGDRILEAGAGTGYNAAIMAAVVGETGHVTTIDV
                     DEDLVAGARAHLTAAGIDNVDVVLGDGALGHAQGAPFDHVIATVGAYEIPAAWLEQLSP
                     DGRLVVPLRLRGTNSRSIVFERHDTGWRSRDSQLAVFMPLRGIGDDARRYVQLTPENDV
                     TLQVHKDQTVNGQALAGVLKSERHEGWSGVAFPPDVSFEWLDLWLCLRLDNALMRMNIK
                     PTAKERGQVAPIFGWGSMATVHDRDLAYLTIRPTTPAPEGGKLYEVGVIGHGPTAQNLV
                     DRVLGEIRTWNDHYRARSVRFEIPDSPTTTDAAAGRFVLERLHRPITIIWE"
     gene            16460..17599
                     /locus_tag="F7P10_RS18950"
                     /old_locus_tag="F7P10_18950"
     CDS             16460..17599
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="F7P10_RS18950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="F7P10_18950"
                     /product="hypothetical protein"
                     /protein_id="WP_176611545.1"
                     /transl_table=11
                     /translation="MTVIDPGQVAFRWFPLVARTRPRCSPLDVRVTELCTLADAAARNL
                     DRAAASTVLNQAALLASDVGLHDLARDWCHQHAATYLRRVPLDAASARRALEPFVNLAR
                     LHIRTGNGDQALRLLGDLYRAIATRRDTTIDGHPLPSSSLTRSSADYQQLHQWLWTVNL
                     ADGTRALTTAGRWNNTLAHLQQHNGVGRRMLDGRQVAVIAHALDGDPEGAQTLLAETAP
                     GEPWENAVTACLTVLCGTAATPDTSTLLDYSLTIDSPPGLVVFDTRLRLSVLAALHDTE
                     HSIGALATRAVTQAIDARDGYAARDVLSNDACAASMTSRQERDLTHVVETCGLGSGTIP
                     RTLHTALSKALTTSKALLASRDCKVFGSVRHSTLSHTRW"
     gene            complement(17708..18274)
                     /locus_tag="F7P10_RS18955"
                     /old_locus_tag="F7P10_18955"
     CDS             complement(17708..18274)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025390.4"
                     /locus_tag="F7P10_RS18955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_18955"
                     /product="DUF4240 domain-containing protein"
                     /protein_id="WP_151010604.1"
                     /transl_table=11
                     /translation="MDTHSPVTAENIGRDQRTEWLTARLAHRPVVEIIEFELHLTAQRK
                     RVDTRHMWGAAWNIFQGWCSDDSFWYFQPWLIGLGHDTFERVAAHPDALADTHEVRRLA
                     GRHRSQWTDEEWPEWESMNYIALNAYDRATGEEEGLEDALETRGLYRICDAFPEDERWD
                     YDDIGQRRAKLPRLTELLGEHHPAT"
     gene            complement(18180..18503)
                     /locus_tag="F7P10_RS42450"
     CDS             complement(18180..18503)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="F7P10_RS42450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_176611546.1"
                     /transl_table=11
                     /translation="MTNLQRMVTAIPLTDDERAAVDDGQAALDKLLEQLVNVPTPAGPT
                     PRDLQRPAGAVLLPIVEVRQSGTLLPWHSKISGHSFTSHGREHRPGPTHRMAHRAPRTS
                     SGR"
     misc_feature    18871..18880
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.07"
                     /tool="antismash"
     gene            complement(19170..20918)
                     /locus_tag="F7P10_RS18965"
                     /old_locus_tag="F7P10_18965"
     CDS             complement(19170..20918)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR00976.1"
                     /locus_tag="F7P10_RS18965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_18965"
                     /product="CocE/NonD family hydrolase"
                     /protein_id="WP_151010606.1"
                     /transl_table=11
                     /translation="MTITIEKDVRVPMRDGVTLATDLYLPEGGPVPVLLVRLPYGKDVV
                     TKLGQPVLITPLAFAEAGYAVVWQDCRGTWSSDGTFGLQVADMADGVDTLQWIRRQPWC
                     DGNVGTYGPSYLGLTQWALASQGPDGLKAIAPTTAPIDFRYVRFGRGGGLFWHTNLLWA
                     VSMNQMLVMRALRRGESDATALLQAAELAADPEPHLRKLPISDQPLLNKQSIWWQKSME
                     HPISDAHWAEVSPSERIADITTPGLHVGGWFDIFVTETTRAFTRLRDEAAGPEARQYQR
                     LIIGPWDHRNQEGLYSDRQFGARANALTADVTGAHVRFFDHHLRGDATADAADAPVRIF
                     VMGIDQWRDEQDWPLPDTRYVDYFLDGSGHANTAGGDGTLTLDAPDGEAADTIRYDPTD
                     PVPTIGGRRLPAGNIAAAAFTAGPLDQSPVETREDVLCFTTPVLDEPLEVTGEVSLVLH
                     VSSSARDTDFTGKLVDVFPDGRALYLTDGLLRARYRTSLTEPELLEPDRVYEMVVDLGP
                     TANVFLPGHRLRLEVSSSNFPHYDRNTNTGGNIPHDVDEPIVAVNTILHGPRHPSRLIL
                     PIIERP"
     gene            complement(20915..21502)
                     /locus_tag="F7P10_RS18970"
                     /old_locus_tag="F7P10_18970"
     CDS             complement(20915..21502)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012655.4"
                     /locus_tag="F7P10_RS18970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_18970"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_176611547.1"
                     /transl_table=11
                     /translation="MAEETEDKRVRRSRAALVEAAVRLVTERGTTAIPVTDLTEAADVS
                     RKLLYLHFGDRDGLLVAATIDLTERWAATGGAQDPETRVVELARHLSEHQTFYRAVLSG
                     SCAFAASEALKEVFGDLNRTTVSVLFGGLDEDALNDVRVFFAAGVMAIVHSWIAGPGSP
                     ADPNALADRLRRLTGIFAESFNRSDAPDEEKA"
     gene            21582..22358
                     /locus_tag="F7P10_RS18975"
                     /old_locus_tag="F7P10_18975"
     CDS             21582..22358
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024950.4"
                     /locus_tag="F7P10_RS18975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_18975"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_151010610.1"
                     /transl_table=11
                     /translation="MNFEGRSAIIAGGAGGLGSATARRLAELGFGVVIVDIDTDRAQAL
                     VSDLGAKAAFVPGDTIDDDVVDRAVAAAGELGSLFAAVSATGVVIRAGRTVEADGTLLS
                     KDVMRANFDLHVLGPFNLARIAAAAMARNEADNDGQCGVIVQTASISAYDAQVTMVPYA
                     AAKGGVASMVLPMARDLAPLGIRVNAIAPGAFGTPRLSDPKIRALLARDNVFPKRVGHP
                     DEYATVVEAIVRTPYLNAQVIRVDGGARLRGDMTQD"
     gene            complement(22448..24361)
                     /locus_tag="F7P10_RS18980"
                     /old_locus_tag="F7P10_18980"
     CDS             complement(22448..24361)
                     /GO_process="GO:0006950 - response to stress [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019632210.1"
                     /locus_tag="F7P10_RS18980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_18980"
                     /product="TerD family protein"
                     /protein_id="WP_151010612.1"
                     /transl_table=11
                     /translation="MHQMSKGANIDLAATGPFTVALSWIDPSGEGEADVSVLLVGPDGK
                     VGSDADFVFYNQPATADESVRLLGKTPTATGSEDRILVDLGALRPEVTRVVVAASRYAG
                     ATFGALDDLRLAVSDSAGEAQLAFDIKDAGTETAFIFGELYRRGEGWKFRAVGQGYESG
                     LAGLASDFGINVDDSEEEDQAPPPQTPEEPAAAVREAPAKPKRVRTAKKKTTVPKAAKV
                     NLAEHPSWQHARLFPVTGLRNDQEREVRATATLLAVMAQVPEFGRRLTARFNAPAGTIQ
                     TFAEASFKHGDGKVRPDGVLRVARAGRIWTALVETKTGGNPLKVDQVEAYLEVAARHGY
                     ETVITLSNDLALDNEHPLKVDKRLLRKVALRHLSWAEVAHEAEMLCLHGVANPVHAWLL
                     SELLHYLRQDNAGCQGFRDMGAAWVPVRNAVTSGTLRLGDRRAMQVAESWEKLIRQLCL
                     RLSGRTGLAIAPVLRKRRDGDASVRRLQTVTSLVETGRMNAEIRVPSAGGPVLLEADLR
                     TGQIETTVEIPAADRARPLTRVHWLLRRLGDASPDLRVEALAPGDKTGPCDLLKNLIAE
                     PGLLVPDNAQQIHTFRLTLATGLGTKRGTEETGFVRSIDTAMDRFHQEVLQVVSPETTS
                     ST"
     gene            complement(24756..25670)
                     /locus_tag="F7P10_RS18985"
                     /old_locus_tag="F7P10_18985"
     CDS             complement(24756..25670)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013775.4"
                     /locus_tag="F7P10_RS18985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_18985"
                     /product="phosphotransferase family protein"
                     /protein_id="WP_176611548.1"
                     /sec_met_domain="APH (E-value: 6.8e-29, bitscore: 100.4,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTPDSATLAWAAGALGAERPARVVRCLAGGSHADTHLLETSAGR
                     AVLRRFPTGDDAAANEARTLTALDGLGGFAPRLLAADPDGARTGRPATLITVLPGAPDI
                     LHTDPGAAAARLGRALARLHAVPTGTLAELRDGVATSDAAPARRLDQGPTGPIVDAHAR
                     TIAAEPRVLTHSDFWAGNVMWSDGELTGVIDWSGGSLAPRGFDVGWCRLDLVILHGSET
                     AAAFLDAYENAAGYPVANVELWDLYTLRSSHQTVETWVPNYRDLGRTDLTADALRARHT
                     AWTHECLHRWNSRTSPSGYADTL"
     gene            complement(25902..26336)
                     /locus_tag="F7P10_RS18990"
                     /old_locus_tag="F7P10_18990"
     CDS             complement(25902..26336)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="F7P10_RS18990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="F7P10_18990"
                     /product="hypothetical protein"
                     /protein_id="WP_151010616.1"
                     /transl_table=11
                     /translation="MVVDFLCNRSGPREVVLSRPDAWQLLGFDAGALREDVIPGLVLTE
                     DDEQTRNYLLSQGPPHRLLVTYRDAKDVLNQLPACEQERLAALSLRSSAESALEIAETG
                     ETNNDHRIGRGAIVPTSLHLMTRPSAFDQLTAMPTLVRRV"
ORIGIN
        1 cagatcggcg gcgatccggg cgttgggccg cccttcggtg aaccactgcg cggcctgcat
       61 ccgtacttgt tctcgtttgt cacggccgac ggcggtcatc ccgccgccct gggggtatct
      121 ggccatgtca ccggcatacg cccacaccga cggtccgtcg acttacccgg ccgccatcac
      181 ccaataaccc tggttagggg cctgattcca caatgggggt gctccgaagt cgcagagccc
      241 tctctgccgc aggccttcaa cggcctggcg gcacaaggac cggacatcgg cccgctcaga
      301 ctgaaagact gggtcacctt taggaaacct gacacaacct gacggagcgc tggtggcagg
      361 cattcggatg ccggacgagc ggcagctacc tctagggcct caccgtgatc tggtcgccgc
      421 cgtccacgat ctttatgagc tggcagggaa accggcggcc cgcaccatca gcgcctggat
      481 ccgcgatcaa gatgatctac ctggcaccct gagccatgag ggcgtcagtg ctgtactgcg
      541 cggtgccagc atgccccggt gggccaactt ggagtcgcta gtacgggttc tggtcgagca
      601 acaacgcgtc gggcaatcgg atgccgaagt caccctcgca cgcatccacg ccttctggca
      661 catggccgac ggcgggatgg ctcggaagcc acacgagggg caggactctg aatcgcaacc
      721 accagattcg caactaccgg cgcacgagac gatcgctcgg tgggatcacc cgcgcctggg
      781 tgtcgtggag ttcagagacc gacaagcctt cattgagatc ttccgagagg taggcggttt
      841 cagtgacgaa ccgtaaccgg gcggacagtg gatggtcacg atttgagcag agcggctcac
      901 tgaacgacct gaacgcggcg attaccgccg cacgtgaagc cgcagagctc gttcccgagg
      961 accatcgaga ccgtgccgct gtcctgaaca acttgggtag tgctctccga gccaggttcg
     1021 agcgaacccg cagcatgccc gatcttgagg aagccctcgc gtcaactcga caggcgcttg
     1081 cagcaagcac cgccgatgac ccgcgacgtc ccgcaacctt gaacagcttg ggcacgatgc
     1141 tgtcggcggc agggcgaatc tcggaggcgt tggaggtcgc ccaggaggct gtcgagatcc
     1201 gccgcgcgct ggccgcgcaa gaccccgaca cctacctgtc cgacatggcg tcctccctca
     1261 gcaatctcgg caaccgcctg tcggcggcgg ggcgaatctg ggaggcgttg gaggtcgccc
     1321 aggaggctgt cgagatccgc cgcgcgctgg ccgcgcaaga ccccgaagct tatgaggctc
     1381 atctagctgg agcgctgtcg aaccttgccg gcttctacct gtcagcaggc gacgttatgc
     1441 gagcgatccc gctgttggac cagaccctgg ccgactacga gcggatgctg ggcggagacc
     1501 acccccatac cctcacaacc cgcaacaacc tcgcctacgc ctaccaagcg gccggtgacc
     1561 tgggccgcgc catcccgctg tacgaacaga ccctggacga tcgggggcgg gtgctgggcg
     1621 gcgaccatcc cgacacgctg gcctcccgca acaacctcgc ctacgcctac caggcggtgg
     1681 gggatctggg gcgggcaatc ccgctgtacg agcagaccct gaacgatcgg gggcgggtgc
     1741 tgggcaccga ccaccccaac acgctgacct cccgcaacaa cctcgcctac gcctaccaag
     1801 cgaccggtga cctgagccgc gccatcccgc tgtacgaaca gaccctgaac gactccgagc
     1861 gggtgctggg caccgaccac cccaacacgc tgacctcccg caacaacctc gctggcgcct
     1921 accaagcgac cggtgacctg agccgcgcca tcccgctgtt ggaacagacc ctgaacgact
     1981 acgagcgggt gctgggcagc gaccatcccg acacgctgac ctcccgcaac aacctcgccg
     2041 gcgcctacca agcggtgggg gatctgcggc gggcgatccc gctgtacgag cagaccctga
     2101 acgattccga gcgggtgctg ggccccgacc accccaccac acagacagtg cagcggaacc
     2161 tctccgcagc caggggagaa gacccagacg ggaagtaagc accacagggc cgcgtcggca
     2221 gcggctcact aatcgtattt acgtgagatt ggctcctgtc acatcccagg ggtgacggcg
     2281 gtgttctccc gagcgtggac ctctgagatc tccactttgg gcctggggcc acggtcggga
     2341 gaagaacgcc aacccggcga ggaccggcgg ccgcgacagg cgcgccgccc ctcggacgtc
     2401 ggtgcgccgt tagccccgcc cagtgttgga cacccagccc gacacgtccc cgcacccagg
     2461 gcacacccag gtgacgccgt gctcgggatg cttggcgtag gtctggccgc accggcacgt
     2521 gccgggggca gcgaacttca gtggcatcat cagcccgcac tccaggcacg ggtgatcgcc
     2581 agttcccatt ccggcgattc gttcctgacg tccgtgccgg ggatggtcgc actgggtcag
     2641 atcacgcgac tgggcaccgc tctggttgat atcgtcctga ttcgtcatga tctacatcat
     2701 ggcgcatcga tacctctctc acctggacct ccgtcggtgt acgaacagat ccgcgacccg
     2761 ggaggacggt cagagagcga ccccttctag aaccggcgct tgaccagcag gtccggcggg
     2821 catgagctct ttctgccgta ttccggaagc gatcgctatt tcatctgagg aaattcagat
     2881 cagcgtgccc acagcggcgg aggggctggt gggggcgacg tagcgggtgg ttcggaacct
     2941 gagtggagcg tatcgggtgg ggcggccggt gactcatgcc tgttctgacc tggcgctggc
     3001 gggcccgcgt acatctgatg aagggttcct tcatcagatg taagcagcgg agggtgaccg
     3061 gatgcgcggt gaggtgccgg gggcggcgcg gcttcggctg gtcgatgggg tgccgttgtt
     3121 gcggcccgag gagcaggtgt tcaccgcgat gctggacggc tggcggaacc agcagctcgc
     3181 gcggaacctg tcgttcggga cgatcgagag ccgacagcga gcagtgaggg cgttcgcgca
     3241 cagcgcggac gcgttgccct gggtctggac gccgcagctg gtggacgagt ggatggggga
     3301 tcttcggtcg gtccgggatc tgaagcggtc gacgctgcgg aactaccagg acgccctgcg
     3361 gtcgttctgc cactacctca ccgacccggc ctacggatgg gcagccgagt gcgaggatcg
     3421 gttcggcacc cacccgatcc aggtcgtcca cgagtggaac agcgcggtgc acgtccagga
     3481 ggctgaggcc gaaccgacca agcgggcttt tacgctggag gagatccagg cgttcctgga
     3541 ctacgccgac gaccaggtca ccgccgttcg cggccgggga cgcaagggct ggctgccggc
     3601 ctttcgggac gcgaccttgt tcaaggtcgc ctacggctac gggctgcgcc gccgggagac
     3661 gcggatgctc gatccggtcg acttcggccg caatccgcag gcgccggagt tcggtgacca
     3721 tggcgtctgc tgcatccgct acggcaaggc caaacctgga tcgccgccca agcgccgcag
     3781 cgtgctgacg gtctggggtt ggatcgttga ggcggctgac cagtgggaga ccgaggtccg
     3841 gccccggttc tccaccgcga ccgccggaac ctactggccc tccgaacgtg gcccgcgagt
     3901 cggctactcc cagatcaaca cccgcttcgc catctaccgc gatgcgctcg gcctggaccc
     3961 ggctctggac ttccactctt tccgccgctc ctacgtgacc catctgatcg aggcgggctg
     4021 ggacgcccgg ttcgttcaag agcaggtcgg ccacgagcac gcctccacca cctcgatcta
     4081 cacctgcgtg tcctccgact tccgcacccg caccctgcgg cgagccctgg acgccactct
     4141 ggacgcggcc ctgcgccccg accgggccgg gagcagccga tgaaacggca ggtcggctac
     4201 cagtggcggc tgcgtgaggt gatggccgag agcggcatgt tcgacaccac cgacctcatc
     4261 ccgctcctag ccgaccgtgg catcaaactc tcctcggtcc aggtctggcg actggtcacc
     4321 cagacacccg aacggctctc cctgccggtc ctggcggcgc tctgcgacat cttctcctgc
     4381 ggaccggaac gtctcatcgc gaccaaagcc gagaacacca cagcccgcaa gaccgctggc
     4441 cacggacccg aggtcgtcga cttggccgag gtcgtccggc ccaaacgcgc ccggatccgc
     4501 cccgaccagt gaccacgctc acctgcggag gctgcggagc gccaggccgc cgctaccgaa
     4561 acggtctctg ccagccgtgt gtcctcaccg cggacctgcg ggccgtcctc gacgacggcg
     4621 ccggtggcat ccgccccgaa ctgctgccgt tcttcgacgc gcttcgcacg atgaccaaac
     4681 cgatcgcggg catcagctgg atcagacgcc cgcacgtcga cgccatgctc cggacgctgg
     4741 ccgaccccgc caccgccttg actcaccaga ccctggactc catgacgccc tggcgctcgg
     4801 tcacctacct ccgcgacctg ctcatgctcc acggcgtcct accagcggca gaccggcatc
     4861 tgctgctctt ccagcgctgg ctccgcgccg tcctcgacga gatcaccgac cccggccagc
     4921 ggcaactggt cgccaggttc gccgcctggc acgtcctcaa ccgcctccgc cgcttcgccg
     4981 cccggggccc gctctcccag acacagacca accaggcccg cgaccaggcc cgcgaccagg
     5041 cccgcgacca ggtccgttcc gccatcgctt tcctgacctg gctcgaaacc cgcgacaaga
     5101 acctcgccga ctgccgccag gccgacatcg acgcctggta tgccgacgga tacacccgcc
     5161 gccgcaacac ccacccgttc ctgcgctggg ccatgaacga caaggcgttg cccaccgtca
     5221 cgatcccgca ccagcccacc gccaacccag ccccgctcag ccaacagcgg cgccttcagc
     5281 tcctgcacca cttcctcacc gacgaccaga tcccgctgct caccagagtc gccgcggtga
     5341 tcgtgctcct ctatgcccag ccggtcaccc ggatcctgcg gctcaccatc gacgacgtca
     5401 tccgcgatgg ccccgcagtc tctctccagc tcggcgaccc gccaagccca gtccccgagc
     5461 ccttcgcctc actcctgctc gcctacctcg accagcgtct caacctcacc accgcgacca
     5521 attccggatc ccgctggctc ttccccggcc gccgcggcgg ccagcctatg accagcgacg
     5581 ccatcacccg gcgcttccgc gaccagggca tcaacagcat cagcggacga acctccgccc
     5641 tgcgctacct cgtcctccag gccccagccc cggtcatctc ccgcatgctc ggctacaccg
     5701 accaacaaac cagccgcacc accgccgacg caggcactcc ttggagccgc tacgcacccg
     5761 acgaccacca cagatgggac gcctagaagg cctctacatc ggcccattcc caataagcct
     5821 gctgagcatc gatctcctcc tgcaggacgc cgaacaaccg aacgggagaa gcgtcttgag
     5881 ggacatcgac agcgaggtga cgcttcccgc tccactcgaa cgccaggccg gcgatctcga
     5941 cctcgccggt gatccgcgcc atgaacgcgt cctgatcaga gcgaggcgtg aacaggaccc
     6001 tgaggactcg gtgccctgag cgttcaagca gctccacgac cgtcgcgccg tcctcagaca
     6061 gccgtacccg atcgttcaga gccagtccgt agacgcggaa cggaagacac gcgaccacat
     6121 agtcgccgcc ctggcatggg cgaagccaca gttgctccct ctgaccggca aggccgaagc
     6181 gctcaaggtc gacatgagcc aggtagttct gcgcagcccg accaaccgga tgctcatgaa
     6241 cgatgaactg caccagaaga agcctcacat ccggcaacac cacagaaagt cacggacgcc
     6301 agagaataca gatcactcga tcaccacgtc ctaccagggt ggcaccctgt agacggccac
     6361 agcccccggt agctcgttcc gttaccgggg gccgcacagc tctggtggaa gcgtctctac
     6421 aggtcgaact cgccgttctt tatccgactg acgagcgtgc cgtacgcgtt ggctcggaga
     6481 gcaacgtggc cgccctcggg gttcctggag tcgcggatcg ctcgggcgtc actgatccgg
     6541 gcgacttcga cacactggtt gccgcctccg ctgcggctgg acttgcgcca caccgggctc
     6601 gacggggcgc cagagttgat caccaagcgt tctccttagt cagagctgat cgtggagttc
     6661 tcggagcatg gcgacggact ctcgggggtc gagagctcct tccagcatgt acgtccaggc
     6721 cagctggtag gtgtccagct ccggttccga ttctaggtag aggtctccca tcagcccctc
     6781 ggcatagacc accggcgaat cctcgggctc gtggaacgtg aggatgacga actcgccctc
     6841 gacgccggcg tgcgccccga aggcgaacgg caggacctga agcgtgacgt tgggaagcgc
     6901 gcccgcctcg atgagcgatg ccagctggcc ccgcatgacg tcacggccgc cgatccggcg
     6961 acggatggcc gactcgtcca ggacgacatg cacctcgggc ggctcctcct tgccgaacag
     7021 cgcctcccgc ctggcggcgc gggccgcgac gcggcgatcg acctcgccgg cttccagggt
     7081 gggccgggtg cggccgatga cggcccgcgc gtactcctcg gtctgcagga agccggggac
     7141 gagctgggcg ttgatcctga tcctcgccgc cgcgctctcc agcccgacgt acgagccggt
     7201 gaacacgtcc gagtacttcg tccaccagct gcggcgccgc gcgtcgcgac cgagctggat
     7261 cagcgcctcg cgctgcggga ccagacgtcg tacaggtcga gcatgtcctc gaggtcgtcc
     7321 gtgctgacgc ggctgcggcc gttctccagc cggtagagct tgctcttgct gaagtcgagc
     7381 cgcttcgccg ccacctccag cgacagtccg gcggcctccc tgaggcgttt cagctctcgc
     7441 atcaggcgac ggcctcgaac ggtcggactc tgatccatgt gcctgcccgc caagtctgcc
     7501 gatcggtgtg tggatatcac cggggtcttc ccggttcgcc agattcgcaa ccggtcattt
     7561 ctgcaaccag tcatgtgtga cctgttgcaa gactgacact gtgcgtacat gatgctagtc
     7621 agatcctggt gctggtgccg cgagatcccc gagaccgcac cgccgaaccg aatcccgtga
     7681 ccggctggag ccgtcgacat ggtcgatgcc ccatggcccc taccggggcc gctccttggt
     7741 cgcgttatcc gcccatcgat ctgaccggct tccggatcgg cacttacggc gctccgcagc
     7801 cctgccagga agagcaccag gtcgccgacc tggttctact actcggaggc gcatgccaca
     7861 tgaacgcacc accgctctgc gagccgtccg cggcgccgga cgagcccgaa cgcacgctcg
     7921 tccggcgcct ggatggcccg caacccgaac atcgagcccg cagtgtgctg tccgaggtac
     7981 tcgctcggct gggcctgacg gacgaagcat tcgaggccga gctcgccgtg aacgagctcg
     8041 tcaccaacgc gcgccagcac gccccgccgc cgtacgagat ccgtatctcg tggacggaga
     8101 tgcgagtgac gatcgcggtc gtggacggcg gcatcgatca cggggccgtg ctcaagctcc
     8161 tgtcgcgggc gacgaccggc tgcccgtcgg agggcgagtc cggccgcgga ctccagatgg
     8221 tcgccgggct gttcggcggc cggtgcggcg ctggagcaac gaggatgtcc agcgggctcg
     8281 tccccgcgaa gcaggtctgg atcgttctac cgcgccaacg ctccgaagtt gtcgtcaggt
     8341 gatggccttg gccttgagcg aggacgagcg ggaagcgatc cggctcgccg gcgactttcg
     8401 cagccgcatc cagcgctggc tcgaccagcg ggaaattcag gggcccttga tcgccctgcc
     8461 gtgcgtcggc atcgacggga agccaaacgt cgaggccagg acgggcgggc gcatcgctcg
     8521 cactctggcg atgggcctgg gtgaacggtc ccacccgcct ccaccttcga cctggcgcac
     8581 ctgacgcggg cgccgctgat accggagagg gctccaccgc tcggccaccg aggagctccg
     8641 tacgtcgccg tgaagtctct tgaattattc atcgctcgcg tgaataatct cagctcgtta
     8701 gcgctatcac gatggacgtg gttgcgcgcc ccgtgtgctc tcggggcgtg cgggcggtcc
     8761 ctcacgcagc tcatgcaggc cagtcccaac ctctccagaa cgactcgaaa ccggcatcgg
     8821 cgactcggtg aaggagccag aaacagtggc agcggagagc ctgaaccagg cgagcaacgt
     8881 catcgacccc gccgtcgcga ccgcctcggg catgtacgac tactacctgg gcggcacgga
     8941 caacttcgcg ggcgaccggc gagccgccca cagggtgatc gccgaagccc cggaggtcct
     9001 gctcctcgcc agggagaacc gccggttcct gcagcgtgcc gtccgcttcc tcgcgcggga
     9061 cgcgggcatg cggcagttcc tcgacatcgg cacgggcctg ccgacgcagg gcaacgtcca
     9121 tgagatcgcc cagcgggagg cggccgatgc ccgcgtcgtg tacgtcgaca acgacccgaa
     9181 ggtgctggcc cactcgcgcg cgctcaagac gacggaagcc ggagccacga gcgtcgttac
     9241 tgcggacctg cgggatccgc agtcgattct cggccacgca gagacgcgcc ggctgatcga
     9301 cttcgatcag ccggtggcga tcctcctcgt ggccgtcctg cacttcatca gcaacgattc
     9361 cgatccctat ggcatcgtcc gccggctctg cgccgcgatg gcgccgggca gttacctcgc
     9421 catctcccac gtcaccgcgg accctcgccc cgagcaggca aacgggctgc ggaaggtcta
     9481 ccggtccacc gcgaaccccg tcacccaccg cacccgcagc caggtcgacc gcttcttcga
     9541 cgagcttgag tacgtcgacc cggggctcgt gtatgtcccg gcgtggcgtc ccgacggcgt
     9601 ctcggacgtc gctcctgaag aggtatggat tctcggcggc gtgggccaga agcagtaacg
     9661 caaccgcgcc cgaagttcct gggcgccgat ggaaaccgct ggttcaagag acttggaggg
     9721 tctcatgctg aggaacagca ccgtagagcc ggaagcagtc gccggaccga ccgacgccgc
     9781 accggacgcc ttcgaactgg acgtgcggct gctcgagatc gcggacccgg ccggtctggt
     9841 gaacgtcacc gacgacgggt gcacgagcac ctgcggggcc tgcatcagca acgcgtactg
     9901 accggctccg tccccgggca tcgaccggcg ccgtcgcgac ggctcgcctg cggcggcgcc
     9961 gctgtccccc ggcctgcaca tcatcgccac ggaggatgcc gtgcctcctt ctgctcgccc
    10021 gcagaagttc aagtccgtcg gcgcggcact cttccgtgcc gccgcccact cctcggaagg
    10081 tcttccgccc tatcccgacc tgaccggcga ggccaccccc gcacgcgtcg tcacgtgggt
    10141 ggactggctc cggcaggttt ggacgaacga gaccgtggtc gatgctctcg aacacgccag
    10201 cccgtcgctg gcccggcagg tgcgcgcggt ctgcgatgcc ccggccccgg ctccgcggga
    10261 gacccggcgc gccgtcctgt cggtcgtccg ctacctgcaa cgcatgacgg gacgcgctac
    10321 gccgttcggc ctgctggccg gtgtggctcc cgcgtccttc ggggccgagc cgctgttccg
    10381 ctggggcccg cggcaccgag ccgctacacg tgccggtgcc ggttggctgg ccggggtcat
    10441 cgagcggttg gaaggctgct ctgagctgct ggcatgcttg ccggtcgccg cgaacaacac
    10501 gctgttcgtc cgcggggacc gcctgatcgt gccctaccgc ccctggaagc gggcgcgcgg
    10561 ggccggtgcc gtcgagatct ccgtccgcca taccgacgcg gtacgggcgg ccgtcgaggc
    10621 agcccgtgac cccatccgca tagaggatct ggccgccaag atccggggtg atttccccgc
    10681 tgcgtcaccg gctcaggtcg ccacgatgct tacggaactc gtcgcacggg gcgtcctcat
    10741 cagcagcttg cacgcgccca gtaccgagcc cgatgcactc cggtacctgg tgacggagct
    10801 ggcggctgcg ggtgcttcgg cggtcgcacc cgttaccggg ctcgccggcg aactccggaa
    10861 gatccacacg cttaccgggc atcacgacct tgccgggccg agcgccgcca aggtgatgcg
    10921 cgcagacgtg tgcgagctga tgcgcttgct ctcgccgtcc gagcagcacc cgatggcgat
    10981 cgatctgcgg ctggacgcgg ctgtcgtgct gccacacgat gtcgcccgcg aggttgagcg
    11041 cgccgcgctc gtcctcgcgc gcaccagcgc cttcccggtg ggcactcccg cttggcgggc
    11101 ctaccatcag cggttctacg agcggtacgg catcggttcg ctggtacctc tccttgacgt
    11161 cgtcagcgac agcggggtcg gctggccgga cggctatcca ggcaccgtga caccggagcg
    11221 ccgctccccg atgtcggccc gcgacagggc gctgctcgcc atcgcccagc aggccgccct
    11281 cgaccgttgc gaggaagtcg tcctggacga ccggctcatc gagtcgctgg agttgtcgtc
    11341 ggagccgctc cggccaccgt cccatctgga gctgggcgtg cgcgtgcgtg ccaccgaccg
    11401 tcgagcgttg cggcggggcc gtttcacggt cgaggtggtc agcgtctcgc gcggggctgg
    11461 tgtgtcgtgc ggccggttcc tgagcgttct tacggagcgg gagcgggccg cgttcgtcgg
    11521 tggcttggcc gacctgccgg gtggcgaccg cggcaccgtg ggcgcgcagc tctccttccc
    11581 gccgttggat ccggcgactg cgcacgtcac gcgggtgccg aagctgcttc cgaccgtgat
    11641 cagcctggcc gagcatcgcc acgacgctcg caccgcgctg gcaccggagg atctcgcggt
    11701 cgggtgtgac ggccgtcgcc tgtacctggc tgatccggcc catggtcggc ggctggaagc
    11761 cttcgggatg cacgcgctca acctggtcac gcacacgccg ccgctcgccc gcttcctcac
    11821 cgagctcggt cgcgcgcaat gcgcccaggt gacgaccttc gactggggcg ccgcggcggg
    11881 cctcctgttc cttccccggc tgcggttcgg ccggacgatc ctgtctccgg cgcggtggcg
    11941 gttggaggcc cgcgagctgc ccgcgcgtgc gcagccttgg gcggcttggg acgccgcgtt
    12001 cgacgagtgg cgaactcgcc gccggatatc tcgattggtc aacctcgctg aaggcgacca
    12061 gctcctgccg ctcgacctgg accggacggc ccaccgagtc ctgctccgta cccacctcga
    12121 cggcgcgccg gaggcggttc tgaccgaagc tccggctccc gacgacgcca gctggtgcga
    12181 cggccgtccg cacgaggtca tcgtgccgct cgtcgccacc gaaccgccgc catggccacc
    12241 gctgcccgag ccgacgtcgg cacgggtcgt ccacgaggat cggagcgaga cgccagctat
    12301 ttcgcgagtt ctgctcgcca gcctgtacgg ggacgtgcac cgccaggaca tcgtccttac
    12361 cgagcatctt ccggttctgc tgcggcggtt ggacgaaccc gcctggtggt tcgtccggta
    12421 ccgggacccc gcgcaccatc tccgccttcg cctcgtcctt cctgaaccgg acgcgttcgg
    12481 cgatgccgcc cgcacggtga gcgcctgggt cgacgaactg cgccgcgtcg gtctgctgcg
    12541 cgaggtgacc tacccgacgt cctggccgga gaccggccgc tggggtgccg gagtggcgtg
    12601 gacggccgcg cgtgccgttt tcgccgcgga ctcgcaggcg tcactcgtcc agctcggcac
    12661 ggctccgcgc ccccacccgc acgccctcgt ggcggcccaa gctgtcgcga tcgccgtcgg
    12721 cttcaccggt ggcgtcgccg aggggatgcg atggctggtc gagcatgtcc ccgccggtgc
    12781 gccggcacgc gtcccccggc cggttttcga gggagccgtc cgcatcgccg atccgtccgg
    12841 cggctgggca gcgctgcgtg cggcaccggg cggcgcaccc atcgcgcgtg cctggcagcc
    12901 gcgcgaccgg gctttggccg agtaccggcc ccatttcccc gggccccata ccgaaggaat
    12961 cgcgttcgac gacgtgctcg cgtcgctcat gcacgtcaac ttcgtccgga cgggcggcat
    13021 cgacttcgac gaggaggcca tcggcctgta cctcgctcgc gccgccgcac tctcctggac
    13081 ggcccgtgca accgggggcc acaggtgaac gacgaacatc ccgcgcgcga gctaggcgac
    13141 gccatcgccg aactgctggc ccatcccgac ggcctgcctg ctcggctgac gtcccgtccc
    13201 tggtggcggc aatcgctggc tcacggggca cccggcatcg ccctgctcca catcgagcgc
    13261 gccgccgccg ggctctcccc gtggcggcgt gcccacgact ggctcgcgta cgcaacccaa
    13321 gcaccactca ctaccgggtt cgatagccac ctgttctacg gggctcccgc cgtcgctcat
    13381 gccctggcct gcgccgccga cctgcttccc ggctcctaca ccggggctct cgaccatctc
    13441 gatcgagtga tcgccgccga cgtccggcgc cgggccagca gcgcgctcgg ctggttggag
    13501 gccgggcatc tgccgtccct gtccgagttc gacctggtgc gtggcctcac cggcatcggc
    13561 tcctacctcc tgcgacgagc tcccggcagc gaggcgaccc gcgccgtcct cgagtacctg
    13621 gtgcgcctga ccgagcccac gcgagacggc gaggagtcgc taccgggctg gtggacgctc
    13681 tcggggcccg acgggcatga gcacgaccac ttcaagggcg gccacgcgaa ctccgggctc
    13741 gcccatggga taggcgggcc gctggcttta ctcgctctcg cctcgcggcg cgacgtcgtc
    13801 gtggatcgtc acctcgacgc gatctctcgc atatgcacct ggctcgaccg ttggcgcacc
    13861 gacactccgt ccgggccgat atggccgtac tgggtcaacc ggcctcaaca gcgcgccgac
    13921 cagcggtcgg tctccggttc gcagcgaccg agctggtgct acggcaccgc cggtctggct
    13981 cgcgcacagc aactcgccgc gctggcgacc ggcgacaccg agcgccggga catggccgag
    14041 cgcgccctga tgcaggccct gaccgacccc gcccaacgct cctcgaccac cgaccccacg
    14101 ctgtgccacg gctacgccgg cctcgcccac atcgccgccc gagttgccgc cgacgccgcc
    14161 ccggacaccg cagaggggct gcatgccctc atccccgatc tcctggattc gatccacacg
    14221 gtctccaccg atcccggtcg tactgccgtc gcgcttctgg gcgatagagg ctgtggaccc
    14281 gccttcctcg aagggggagc cggcattgcc ctggccgtcc tcacgcctac cggcaccgga
    14341 attccaaggt ctggctggga cacatgcctg ctcgtcgcct gatccgtgag gaacgtttcg
    14401 cgatgcccga cctcgagtgg cgccagtaca acatctactt cccggaccgc cggacagccg
    14461 gtgcagtcgc agcccacgat ctacgtcccg cgctggtcgc tgcgcaggaa gctggcgtcc
    14521 tgcacggctg gtggttcatg cgcaagcacc cgtggcggct tcgctacatc ccgcgcgttg
    14581 ccgggtcttc cgccgtcgcc gagttgctgg acgacctggc cgccaccggt cggatcaaag
    14641 catggacgcc tggaatctac gagcccgaga cagcggcatt cggcggcaac accgcgatgg
    14701 ctatcgccca cacgctcttc caccacgaca gccgtcacgt actcgcccgc gccgcacaat
    14761 gctccgtccc gccgctgggg ctacgggaga cgacggctct gctgtgcaac gcgatgttcc
    14821 gcgctgcggg cttggactgg tacgagcagg gcgacgtctg gtcgaaggtc gcagcgctcc
    14881 gcccagtcgc accggcggcg tcccgccccc agcagcaacg ggcggcgcac cggctgatga
    14941 ccgtcgatat ccacgacctg tgcggcagcg gcccgctcgg cggctacgag ggctggatca
    15001 gcgccttcga acaagcgggg cgcgccctgg ccgcccttgc ccacgagggc ttcctgacgc
    15061 ggggactgcg tgccgtcctc gcccaccacg tcgtcttcca tttcaaccgc gcctcactgc
    15121 cggtaacaga ccaggccgcc ctggcggcag tgctgtcgga caccgtcttc cagtccgtcc
    15181 cgaactcgcc gaccacatcc accacgacga ttaaggtcca accgatgact actctgagtg
    15241 acaatcgtgc cgcatccgcc gacgaactgc gtgccgaact ggccgatcgc ctgcgcgacc
    15301 ggaacgtcct gaacagcccg gcgatcgagg aagccttcag gcgcacgccc cggcacctct
    15361 tcctgcctgg ggtaccgctc gatcgggcgt acgccgacac ccccgtctac acgaagacgg
    15421 aagacggcgg tgagcacatc agcgcggcgt cccagcccgg gatcgtcacc atgatgctcg
    15481 agcaactcga ccctcggccc ggcgaccgca tcctggaggc cggcgcgggc accggctaca
    15541 acgccgccat catggccgca gtcgtcggcg agaccggcca tgtcaccacc atcgacgtgg
    15601 acgaggacct cgtcgctgga gcccgcgcgc acctgaccgc cgcaggcatc gacaacgtcg
    15661 acgtcgttct cggcgacggc gccctcggcc atgcccaggg ggcgcccttc gaccacgtga
    15721 tcgccaccgt cggcgcgtac gagatcccgg cagcctggct ggagcaactc tcccccgacg
    15781 gccgcctcgt cgtgccgctc cgccttcgcg gcaccaactc ccgcagcatc gtcttcgaac
    15841 gccacgacac cggctggcgg agccgcgaca gccagctcgc cgtcttcatg ccgctgcgcg
    15901 gcatcggcga cgacgcccgc cgctacgtcc aactcacgcc ggagaacgac gtgacgctcc
    15961 aggtccacaa ggaccagaca gtgaacggcc aggctctcgc cggagtcctg aaaagcgagc
    16021 gccacgaggg ctggtccggc gtggcgttcc cgccggacgt ctccttcgaa tggctcgacc
    16081 tatggctgtg cctgcggctg gacaacgccc tgatgcgcat gaacatcaag cccacggcca
    16141 aggagcgagg ccaggtcgcg cccatcttcg gttggggctc gatggcgacc gttcacgacc
    16201 gcgaccttgc ctacctcacc atccgtccga ccacccccgc tcccgagggc ggcaagctct
    16261 acgaagtcgg agtcatcggc cacggcccca ccgcgcagaa cctcgtggac cgcgtcctcg
    16321 gagagatccg aacctggaac gaccattacc gcgcccgcag tgtccggttc gagattcccg
    16381 atagcccgac gacgaccgat gccgccgcgg gccggttcgt cctggaacgt cttcaccgtc
    16441 ccatcaccat catctgggag tgacggtgat agatccgggc caggtggcat tccgctggtt
    16501 ccctctcgtc gcacgcacgc gaccgcgttg ctcgccgctc gacgtccggg tcaccgagct
    16561 atgcaccctg gccgacgccg ccgcccggaa cctcgaccgg gcggcggcgt ccaccgtcct
    16621 caaccaggca gcgctcctgg cctcggacgt cggcctgcac gacctggccc gagactggtg
    16681 ccaccagcac gcagccacct acctccgccg cgtccccctg gacgccgcgt ccgcacgccg
    16741 agccctcgaa cccttcgtca atctcgcccg tctgcacatc agaaccggca acggcgacca
    16801 ggccctacgc ctccttggcg acctctaccg agcaatcgcc actcgcagag acacgaccat
    16861 cgacggccac ccgctgccga gctcctcgct cacccgctcc tcggccgact accagcagct
    16921 acaccagtgg ctctggacgg tgaacctcgc ggacggaaca cgcgccctca ccacagcggg
    16981 ccgctggaac aacacactcg cccacctgca gcaacacaac ggagtcggcc gacgcatgct
    17041 ggacggccga caggtagccg tcatcgcgca cgccctcgac ggcgatcccg agggggccca
    17101 gacactgctc gctgagacag cacctggcga gccgtgggag aacgcagtga cggcctgcct
    17161 gaccgtgctc tgcggcaccg cagccacgcc ggacaccagc acactcctgg actattcact
    17221 gacgatcgat tcccctccag gcctggtcgt cttcgacact cgcctgcgcc tgtccgtcct
    17281 cgccgccctc cacgacaccg agcactcgat cggcgcgctc gccacccgtg cggtcaccca
    17341 ggccatcgac gcacgcgacg ggtacgcggc tcgcgacgtc ctgtcgaacg acgcctgcgc
    17401 cgcctcgatg acgagccgtc aagaacgcga cctcacccac gtcgtcgaga cctgcggctt
    17461 gggaagcggc acgatccctc gtaccctcca caccgcactc tcgaaggcgc tgaccaccag
    17521 caaggccctg ctcgcctcgc gggactgtaa ggttttcggc tctgtccgac attcgactct
    17581 gtcgcatact cggtggtagc ggagagtgag ctatccgagg aggatgcggt gacgcaggaa
    17641 acgaaagccc agcccggccg tacatctgtc tcttgatcag cttgcttctt atgtggaatc
    17701 agatctgtca agtggcgggg tggtgctcgc ccagcagttc agtgagtcga gggagctttg
    17761 cgcgacgctg tccgatgtcg tcgtagtccc agcgttcgtc ctcagggaag gcgtcgcaga
    17821 ttcggtagag accccgtgtc tcaagggcgt cttcaagtcc ttcttcttct ccggtggcgc
    17881 ggtcgtaggc gttgagcgcg atgtagttca tgctttccca ttccggccac tcctcgtccg
    17941 tccactgtga cctgtggcgt ccggcgaggc gacggacttc gtgggtgtcg gcgagggcgt
    18001 cggggtgggc ggcgacgcgt tcgaaggtgt cgtggccgag gccgatgagc cagggctgga
    18061 agtaccagaa gctgtcgtcg gagcaccagc cctgaaagat gttccaggca gcgccccaca
    18121 tgtgtcgggt gtcgacccgc tttcgttggg ctgtgaggtg cagttcgaac tcgatgatct
    18181 caacgaccgg acgatgtgcg aggcgcgcgg tgagccattc ggtgcgttgg tcccggccga
    18241 tgttctcggc cgtgactggt gaatgagtgt ccagaaatct tcgagtgcca cggcagcaag
    18301 gtaccgctct gccggacttc cacgatcggc aggagcaccg cgccggctgg gcgctgaagg
    18361 tcgcgcggag taggtccggc gggggtgggg acgttgacga gctgctcgag gagtttgtcc
    18421 agggcggctt ggccgtcgtc gactgcggcg cgttcgtcgt cggtgagcgg gatggcggtg
    18481 accatgcgct gcaggttggt catggcctcc aagagcagtg ctttggagga gtccttgggt
    18541 gcggttcctt ttcaggggtg cgacacgagg tcgcgcatgg cgagtgaact ggcagattgg
    18601 aggccggtta tgccgggtgc gtagttcctg atcagtgttc gagatcggtc cccgccccga
    18661 catgcgtccg caggtcctgc ctgtgggggt gtgaagctcg gggaagacgc ccaagggccc
    18721 ctgctccgtc cgggggaaca accgggcaag gggaagtccg gacgggtgaa cgcaagtgaa
    18781 cccttcgatg aggcctcgtc agggaaagcc ctggaaggcg ggacggaaac cagggtggta
    18841 gggcctggcc tgggccgagc ggcgcaagcc gaaggcggcg ccccgggccg gatcgtcgca
    18901 ctcgtaagca gcatccggca gacggggtgg ggacgccatc cccgaccggc ccgccgacga
    18961 gtccgggctc gcgcactggc ccgcacctgg ccacggacga cgatgacgct caccgtcgat
    19021 cagtggtcac tcgcccactc cgcctgattt accgggcttc ggtatccacc cgaagcccgg
    19081 tcgcgcacga acgcgccaag cgcccctggg gcgtcgcagc ggtcctcgac caccacctga
    19141 tcgcgcaggg gtggtcgagg tcctgcccgc tacggacgtt cgatgatcgg gaggatcagg
    19201 cggctggggt gccggggacc gtgcaggatc gtgttgaccg cgacgatggg ctcgtcgacg
    19261 tcatggggga tgttgccacc ggtgttggtg ttgcggtcgt agtgcgggaa gttgctgctg
    19321 gagacctcca ggcgcaggcg gtggccgggg aggaacacgt tcgcggtcgg gccgaggtcc
    19381 acgaccatct cgtagacccg gtcgggttcg agcagttcgg gctcggtgag cgaggtgcgg
    19441 taccgcgcac gcaggaggcc gtcggtgaga tagagggcgc ggccgtccgg gaagacgtcg
    19501 acaagctttc cggtgaagtc ggtgtcgcgc gccgacgacg acacgtgcag caccagagac
    19561 acctccccgg tcacttccag cggctcgtcc aggacggggg tggtgaagca cagcacgtcc
    19621 tcgcgggtct cgaccgggct ctggtcgagc ggccccgcgg tgaaggcggc cgcggcgatg
    19681 ttaccggccg ggaggcgtcg gccgccgatg gtggggaccg gatcggtggg atcgtaacga
    19741 atggtgtcgg ctgcttcgcc gtccggtgcg tcgagggtga gggtgccgtc tccaccggcc
    19801 gtgttggcgt ggccggatcc gtcgaggaag tagtcgacgt agcgggtgtc gggcagcggc
    19861 cagtcctgct cgtcgcgcca ctggtcgatg cccatcacga agatccgtac cggtgcgtcg
    19921 gcggcgtcgg cggtggcgtc accacgcagg tggtgatcga agaagcgcac gtgcgcgccg
    19981 gtgacgtccg cggtcagcgc attggcgcgt gcaccgaact gccggtcgct gtagaggcct
    20041 tcctggttgc ggtgatccca cggcccgatg atgagccgct ggtattgcct ggcctcgggg
    20101 ccggcggcct cgtcgcgcag ccgggtgaac gcccgcgtgg tctcggtgac gaagatgtcg
    20161 aaccacccgc ccacgtgcag gcccggggtg gtgatgtcag cgatccgctc gctgggcgag
    20221 acctcggccc agtgggcatc tgagatcggg tgttccatgg atttctgcca ccagatcgac
    20281 tgcttgttca gcaacggttg gtcactgatc ggcagcttgc gcaggtgggg ctcggggtcg
    20341 gcggccaatt ccgcggcctg gagcagggct gtcgcgtcgc tctcgccccg ccggagcgcc
    20401 ctcatcacga gcatctgatt catgctcacg gcccacagaa ggttcgtgtg ccagaacagc
    20461 cctccgcccc ggccaaaccg gacgtaccga aagtcgatgg gggcggtagt gggtgcgatg
    20521 gccttgagcc cgtccggccc ctgcgatgcg agcgcccact gggtcaagcc caggtaggac
    20581 ggtccgtagg tgccgacgtt cccatcgcac cagggctgcc gacggatcca ttgcagggtg
    20641 tcgaccccgt cggccatgtc agcaacctgc agaccgaatg tgccgtccga actccatgtt
    20701 ccgcggcagt cctgccacac cacggcgtaa ccggcctcgg cgaacgccag cggagtgatc
    20761 agcaccggct ggccgagctt ggtgaccacg tccttgccat agggcaaccg gacgagcaga
    20821 accggcacgg gcccgccctc gggcaggtac agatccgtgg ccagcgtcac cccgtcccgc
    20881 atgggcactc ggacatcttt ctcaattgtg atggtcatgc cttctcctcg tcaggcgcgt
    20941 cggaccggtt gaaggattca gcgaagatcc cggtaaggcg ccgcaggcga tcggccaggg
    21001 cattcggatc ggcaggggat ccgggcccgg cgatccagct atggacgatc gccatcacgc
    21061 cggccgcgaa gaacaccctc acgtcgttca gcgcatcctc gtcgaggccg ccgaacagga
    21121 cgctgacggt cgtgcggttg aggtcgccga acacctcctt gagggcctcg ctcgcggcaa
    21181 aggcacacga gccgctgagt accgcccgat agaacgtctg gtgctcggag aggtgccgtg
    21241 cgagctctac cactctcgtt tcggggtcct gcgcgccgcc cgtggccgcc caccgctcgg
    21301 tgagatcgat cgtcgccgcg accagcagcc cgtcccggtc accgaagtgc aggtagagca
    21361 atttccggct gacgtcggcg gcctcggtga gatcggtgac cggtatcgcc gtggtgccgc
    21421 gctcggtcac caggcgaacg gccgcttcca ccagcgccgc gcgggatcgc cgcaccctct
    21481 tgtcttccgt ctcctctgcc acaccaccag aacttaccca cctgttccaa aatacacaag
    21541 tgggtagtaa ccttgggtgg gtcgaaagag aagaggggac gatgaacttc gagggacggt
    21601 cagcaatcat cgccgggggt gccggcgggc tcggcagcgc cacggctcgg cggctcgcgg
    21661 agctgggctt cggtgtcgtc atcgtggaca tcgacacaga ccgggcacag gcgctcgtga
    21721 gcgacctcgg ggcgaaggcc gcgttcgtgc ccggtgacac gatcgatgac gacgtggtcg
    21781 accgcgcggt cgccgccgcc ggtgaactcg gctcgctctt cgccgccgtc tcggcgaccg
    21841 gcgtggtcat ccgcgccgga cgcaccgtgg aagccgacgg cacgctgctg tcgaaagatg
    21901 tgatgcgcgc gaacttcgat cttcacgtgc tcgggccgtt caacctggct cggatcgcgg
    21961 ccgccgccat ggcgcgcaac gaggccgaca acgacggcca gtgcggcgtc atcgtgcaga
    22021 ccgcatcgat cagcgcatat gacgctcagg tcacgatggt tccctacgcg gctgccaagg
    22081 gcggcgtcgc gtccatggtg ctgccgatgg cccgcgatct cgcgccgctg ggaatccgtg
    22141 tcaacgcgat cgcgcccggc gcgttcggca cgccgcggct ttcggaccca aagatccggg
    22201 cgttgctcgc acgcgacaac gtgttcccga aacgcgtcgg acatcccgac gagtacgcga
    22261 ccgtggtcga agccattgtg cggacgccgt atctcaacgc gcaggtcatc cgcgtagacg
    22321 gcggcgcccg cctccggggg gacatgactc aggactagct aggacgggtc tgtccagtta
    22381 acggcgcgcg ccgttaactg gaccgacccc gtctcgcctg cacacggggt catagccggg
    22441 gtctggctca agtcgaggag gtggtctcgg ggctcacaac ctggagtacc tcctggtgga
    22501 agcggtccat ggcggtatcg atgctgcgga cgaagccggt ttcctcggtg ccgcgtttgg
    22561 tgcccagccc ggtcgcgaga gtcaggcgga aagtgtggat ctgttgagcg ttatcgggaa
    22621 ccagaaggcc gggttcggcg atgaggttct tcagcaggtc gcacggaccg gtcttgtccc
    22681 cgggagcgag cgcctcgacg cggaggtccg gagaggcgtc gcccagccgg cgcagcaacc
    22741 agtgcacgcg ggtgaggggg cgtgcgcggt cggccgcggg gatctcgacg gtggtctcga
    22801 tctgcccggt gcgcaggtcg gcttcgagga ggaccgggcc gccggcgctg gggacgcgga
    22861 tctcggcgtt catgcggccg gtctccacca gtgacgtcac ggtctgcagg cgccgtaccg
    22921 aggcgtctcc gtcgcgccgc ttgcgcagga cgggggcgat ggccaagccg gtccggccgc
    22981 tgagacgcag gcatagctgc cggatcagct tctcccagct ctcggccacc tgcatcgcgc
    23041 gccggtcccc gagccggagc gtccccgagg tgacggcgtt gcgaaccggc acccatgcgg
    23101 cgcccatgtc ccggaagccc tggcagccgg cgttgtcctg acgcaggtag tgcagcagct
    23161 cgctcagcag ccaggcgtgg acggggttgg ccacgccgtg gaggcagagc atctcggcct
    23221 cgtgagcgac ttcggcccac gacagatggc gcagcgcgac cttgcgcagc agccgcttgt
    23281 cgaccttcag cggatgctcg ttgtcgaggg ccaggtcgtt ggacagagtg atcacggtct
    23341 cgtagccgtg ccgggccgcc acctcgagat aggcctcgac ctgatcgacc ttgagagggt
    23401 tgccgccggt cttggtctcg accagggcgg tccagatcct cccggcacgg gccacgcgca
    23461 gcacgccgtc gggccggacc ttgccgtcgc cgtgcttgaa ggacgcctcg gcgaaggtct
    23521 ggatggttcc ggccggggcg ttgaagcggg cggtcaggcg ccgaccgaac tcgggcacct
    23581 gcgccatcac cgccagcagc gtggcggtgg cgcgcacttc gcgttcctga tcgttgcgca
    23641 ggccggtgac cgggaacaac cgtgcatgct gccaagacgg atgctcggcc agattgacct
    23701 tggccgcctt gggcacggtc gtcttcttct tggccgtgcg gacccgcttg ggcttggcgg
    23761 gcgcctcccg gacggccgcc gcaggttcct ccggcgtctg tggcggaggc gcttggtcct
    23821 cttcctcgct gtcatcgacg ttgatgccga agtcggacgc cagacccgcg agcccggact
    23881 cgtaaccctg tccgaccgcc cggaacttcc agccctcgcc cctgcggtag agctccccga
    23941 agatgaatgc ggtctcggtg ccggcgtcct tgatgtcgaa ggccaactgc gcctctcctg
    24001 cactgtcgga gacggccagg cgcagatcgt caagtgcccc gaacgtcgcc cccgcgtagc
    24061 ggctggcggc cacgaccacg cgcgtcacct cgggccgcaa cgccccgagg tcgaccagga
    24121 tgcggtcctc gctgccggtc gcggtgggcg tcttgcccag caggcgcacc gactcgtccg
    24181 cggtcgccgg ctggttgtag aagacgaagt cggcatcgga cccgaccttg ccgtcgggac
    24241 cgaccaggag caccgagacg tcggcctcac cctcgccaga aggatcgatc cagctcaacg
    24301 ccaccgtgaa cggccctgtc gccgcgaggt cgatgttcgc gcccttggac atctgatgca
    24361 tcgcgccgac tcctttgctc acgtctgatc tcgcgcgtac ggcgggagcg atgaaggctg
    24421 cgtagagcga tcacctgcat gcgcagcgcc agcgtacgtc gggcggccac gacggcgccc
    24481 cggctcggcg gggaggggcc acacccggcc accgatcgcg cttccgggac ctgctgttgt
    24541 gaacgccgat gtcgtgcaca cggccgacct ggagaacgcc gcggaactcg tcatcctctc
    24601 cttctgctgg tgacgtgccg atattccgaa ggacgtgcga ggaccatggg cgcgacgtgc
    24661 acgggatcat gttcgtccgg tgctgcttcc tcgtggacct ctggggccgg ggcgtcccgc
    24721 gatgttgccg ggggtcttgt cggccgcgtg gtcggctaca gggtgtccgc gtacccgctg
    24781 ggtgaggttc ggctgttcca gcggtgcagg cattcgtggg tccaggcggt gtggcgggcg
    24841 cggagggcgt cggccgtcag gtcggttcgt ccgaggtcgc ggtagttcgg cacccaggtt
    24901 tctacggtct ggtgcgagct gcgcagggtg tacaggtccc acagttcgac gttggcgacg
    24961 gggtacccag cggcgttctc gtaggcgtcg aggaatgccg cggcggtttc ggagccgtgc
    25021 aggatgacga ggtcgaggcg gcaccagccg acgtcgaacc cgcgcggggc caggctgccg
    25081 cccgaccagt cgatcacgcc ggtgagttcg ccgtcgctcc acatgacgtt gccggcccag
    25141 aagtcggagt gggtcagcac gcgtggttcg gcggcgatcg tccgggcgtg ggcgtcgacg
    25201 atggggcccg tggggccctg gtcgaggcgc cgggcgggtg cggcgtcgga ggtggcgacg
    25261 ccgtcccgga gttcggccag ggtgccggtc gggacggcgt gcaggcgggc cagggcccgg
    25321 ccgagccgcg cggcggcggc cccgggatcg gtgtgcagga tgtcgggtgc cccaggcagc
    25381 acggtgatca gtgtggccgg acgtccggtg cgggcgccgt cggggtcggc ggccagcagt
    25441 cgcggtgcga agccgccgag accgtcgagc gcggtgaggg tgcgggcctc gttggcggcg
    25501 gcatcgtccc cggtggggaa tctgcgcagc accgcgcggc ccgcgctggt ctccagcagg
    25561 tgcgtgtcgg cgtgcgagcc cccggccagg caccggacga cgcgcgcggg ccgctccgcg
    25621 ccgagcgccc cggcggccca agcgagcgtc gcggaatcgg gggtgttcac cgggcccacc
    25681 gtagtggccg gacattggcg agcagacgct cgaagtcccc caaagcccca acggcgccct
    25741 gcccccaagc ggttgggcac cgttggtccg atcagtcttc atgcgcgtcg tcgacgacgg
    25801 tgcaagcgag ggcgcagcgg caacgagacg tccgtgtcaa cgcgtcccct gcccgaccag
    25861 gcaaacggca cctcaggaac acaccgcccg gcatcaactc ctcaaacgcg tctcacgagg
    25921 gtcggcatcg ccgtgagttg gtcgaaggcg gacggacgcg tcataaggtg cagcgacgtg
    25981 gggacgatcg caccgcgtcc aatccgatga tcgttgttgg tctcaccggt ctcggcgatc
    26041 tcgagagcgg attccgcgga tgaccgtagg gacagcgccg ccaaccgctc ttgctcgcaa
    26101 gcaggcagtt gattgaggac gtccttcgca tcacggtatg tcacgagtag tcggtgtggt
    26161 ggcccctggc tgagcaggta gttgcgagtc tgctcgtcgt cttcggtcag gacgaggccg
    26221 ggaatcacgt cctcccggag ggcgccggcg tcgaagccga gtagctgcca ggcgtccggg
    26281 cgggagagca cgacttccct gggcccggat cggttgcaga ggaagtccac gaccatgtgg
    26341 cggacggcgt cttcggctcc tggtcctgag agggcgaacc gggctccttc aaagggagcc
    26401 agggaccgcg acgccgggac cgtgacgtcg gggttcggcc tgtcgttcga ggactccaga
    26461 agt
//
