LOCUS       NZ_CP044407            22622 bp    DNA     circular CON 28-JUL-2024
DEFINITION  Actinomadura sp. WMMB 499 strain WMMB499 chromosome, complete
            genome.
ACCESSION   NZ_CP044407
VERSION     NZ_CP044407.1
KEYWORDS    RefSeq.
SOURCE      Actinomadura sp. WMMB 499
  ORGANISM  Actinomadura sp. WMMB 499
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Thermomonosporaceae; Actinomadura.
REFERENCE   1  (bases 1 to 9187113)
  AUTHORS   Braun,D., Bugni,T.S., Chevrette,M.G. and Currie,C.R.
  TITLE     Draft genome of Actinomadura sp. WMMB499
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9187113)
  AUTHORS   Braun,D., Bugni,T.S., Chevrette,M.G. and Currie,C.R.
  TITLE     Direct Submission
  JOURNAL   Submitted (26-SEP-2019) Pharmacy, University of Wisconsin-Madison,
            777 Highland Ave., Madison, WI 53705, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Canu v. Oct-2016
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 300.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_008824145.1-RS_2024_07_28
            Annotation Date                   :: 07/28/2024 05:00:58
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,523
            CDSs (total)                      :: 8,413
            Genes (coding)                    :: 8,251
            CDSs (with protein)               :: 8,251
            Genes (RNA)                       :: 110
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 92
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 162
            CDSs (without protein)            :: 162
            Pseudo Genes (ambiguous residues) :: 0 of 162
            Pseudo Genes (frameshifted)       :: 64 of 162
            Pseudo Genes (incomplete)         :: 108 of 162
            Pseudo Genes (internal stop)      :: 10 of 162
            Pseudo Genes (multiple problems)  :: 19 of 162
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 04:12:41
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2185005
            Orig. end                         :: 2207627
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP044407.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Genome not circularized.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22622
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /region_number="8"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     cand_cluster    1..22622
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22622
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12622](+)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12622
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     gene            complement(1188..2816)
                     /locus_tag="F7P10_RS09590"
                     /old_locus_tag="F7P10_09590"
     CDS             complement(1188..2816)
                     /NRPS_PKS="Domain: AMP-binding (33-428). E-value: 8.1e-105.
                     Score: 342.7. Matches aSDomain:
                     nrpspksdomains_F7P10_RS09590_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR01733.1"
                     /locus_tag="F7P10_RS09590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_09590"
                     /product="amino acid adenylation domain-containing protein"
                     /protein_id="WP_151009023.1"
                     /sec_met_domain="AMP-binding (E-value: 3.6e-106, bitscore:
                     354.2, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRRLVAAPGALAIHDRINRTAVEYPDDRGVAALFERQAVRTPDAT
                     AVVHRERTLSYRELDLLADGLAARLHEAGVGRGDVVGVCCARSPELIAALLAVLKCGAA
                     YLPFDPDWPDGRLRLVLGRARCGVVVTDRPPALRARLPEQRFVPADGAAGGAVSGAAPA
                     VRADPDDIAYINFTSGSTGTPKGVPIRHRSIVRLVHAARYARLDEHARLLQLAPISFDA
                     ATFEIWGALLNGGTCVLYPSAFLRFSELRKVLEAQRVTVVWLTAALFNTIVDEAPATLA
                     SVGTILTGGEAHSLRHIAAALRHYGPDRIVNAYGPTESTTFATYHPVRALDPDGSPLPI
                     GTPIQNTRLYLVDGDRLCGAGETGEVWLAGPGLSPGYLANPAATRERFVERDIGGRRER
                     LYRTGDRGRFRPDGAVVFLGRLDDQVKINGHRIEPGEVVHHLNRHPHVRQSHVVVGATA
                     AGERTLVAFVVPEHEACTAASVREHLRAELPKYLIPSVIHFCAALPLSANGKVDRRALL
                     TLHERATGAPVTAPDRPHPNPDETD"
     CDS_motif       complement(1506..1568)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_F7P10_RS09590_0005"
                     /evalue="1.30E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="F7P10_RS09590"
                     /protein_end="437"
                     /protein_start="416"
                     /score="36.4"
                     /tool="antismash"
                     /translation="FLGRLDDQVKINGHRIEPGEV"
     aSDomain        complement(1533..2717)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_F7P10_RS09590_AMP-binding.1"
                     /evalue="8.10E-105"
                     /label="F7P10_RS09590_AMP-binding.1"
                     /locus_tag="F7P10_RS09590"
                     /protein_end="428"
                     /protein_start="33"
                     /score="342.7"
                     /specificity="substrate consensus: Val"
                     /tool="antismash"
                     /translation="FERQAVRTPDATAVVHRERTLSYRELDLLADGLAARLHEAGVGRG
                     DVVGVCCARSPELIAALLAVLKCGAAYLPFDPDWPDGRLRLVLGRARCGVVVTDRPPAL
                     RARLPEQRFVPADGAAGGAVSGAAPAVRADPDDIAYINFTSGSTGTPKGVPIRHRSIVR
                     LVHAARYARLDEHARLLQLAPISFDAATFEIWGALLNGGTCVLYPSAFLRFSELRKVLE
                     AQRVTVVWLTAALFNTIVDEAPATLASVGTILTGGEAHSLRHIAAALRHYGPDRIVNAY
                     GPTESTTFATYHPVRALDPDGSPLPIGTPIQNTRLYLVDGDRLCGAGETGEVWLAGPGL
                     SPGYLANPAATRERFVERDIGGRRERLYRTGDRGRFRPDGAVVFLGRLDDQVKIN"
     CDS_motif       complement(1653..1739)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_F7P10_RS09590_0004"
                     /evalue="3.30E-11"
                     /label="NRPS-A_a6"
                     /locus_tag="F7P10_RS09590"
                     /protein_end="388"
                     /protein_start="359"
                     /score="35.4"
                     /tool="antismash"
                     /translation="AGETGEVWLAGPGLSPGYLANPAATRERF"
     CDS_motif       complement(2103..2135)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_F7P10_RS09590_0003"
                     /evalue="9.90E+01"
                     /label="NRPS-A_a2"
                     /locus_tag="F7P10_RS09590"
                     /protein_end="238"
                     /protein_start="227"
                     /score="-2.5"
                     /tool="antismash"
                     /translation="WGALLNGGTCV"
     CDS_motif       complement(2244..2303)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_F7P10_RS09590_0002"
                     /evalue="9.60E-09"
                     /label="NRPS-A_a3"
                     /locus_tag="F7P10_RS09590"
                     /protein_end="191"
                     /protein_start="171"
                     /score="27.4"
                     /tool="antismash"
                     /translation="AYINFTSGSTGTPKGVPIRH"
     CDS_motif       complement(2490..2531)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_F7P10_RS09590_0001"
                     /evalue="4.80E-05"
                     /label="NRPS-A_a2"
                     /locus_tag="F7P10_RS09590"
                     /protein_end="109"
                     /protein_start="95"
                     /score="16.6"
                     /tool="antismash"
                     /translation="LAVLKCGAAYLPFD"
     gene            complement(2773..3564)
                     /locus_tag="F7P10_RS09595"
                     /old_locus_tag="F7P10_09595"
     CDS             complement(2773..3564)
                     /NRPS_PKS="Domain: Thioesterase (21-232). E-value: 6.1e-41.
                     Score: 133.2. Matches aSDomain:
                     nrpspksdomains_F7P10_RS09595_Thioesterase.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thioesterase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1004: thioesterase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013166.4"
                     /locus_tag="F7P10_RS09595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_09595"
                     /product="thioesterase II family protein"
                     /protein_id="WP_151009024.1"
                     /sec_met_domain="Thioesterase (E-value: 2.6e-39, bitscore:
                     134.7, seeds: 16, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 2.1e-09, bitscore:
                     37.3, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPPDGDPWLLRLKRASREPAVTLICVPYAGGNPALFRSWADALDD
                     NVGLVAVRLPGRGSRIKEPSCADWATLLARASAALAPLLDAPHAFFGHSFGGRTAYELA
                     HLAAAEHPGRTVRLFVSGCRSPNRHRRPHLHPLPDAEFRAALRDMGGMPEDLLASEPLM
                     RMLVPAVRSDLRLAELWDDRAATPLDVPLTVLYGRDDPIDPLAAMADWPAFGGRGCELV
                     ELPGAHFFVDSHRGLVLDVINERLGTSGATAGGRPRGAGHS"
     aSDomain        complement(2869..3501)
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_F7P10_RS09595_Thioesterase.1"
                     /evalue="6.10E-41"
                     /label="F7P10_RS09595_Thioesterase.1"
                     /locus_tag="F7P10_RS09595"
                     /protein_end="232"
                     /protein_start="21"
                     /score="133.2"
                     /tool="antismash"
                     /translation="TLICVPYAGGNPALFRSWADALDDNVGLVAVRLPGRGSRIKEPSC
                     ADWATLLARASAALAPLLDAPHAFFGHSFGGRTAYELAHLAAAEHPGRTVRLFVSGCRS
                     PNRHRRPHLHPLPDAEFRAALRDMGGMPEDLLASEPLMRMLVPAVRSDLRLAELWDDRA
                     ATPLDVPLTVLYGRDDPIDPLAAMADWPAFGGRGCELVELPGAHFFVD"
     CDS_motif       complement(3250..3300)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_F7P10_RS09595_0001"
                     /evalue="6.00E-06"
                     /label="NRPS-te1"
                     /locus_tag="F7P10_RS09595"
                     /protein_end="105"
                     /protein_start="88"
                     /score="18.8"
                     /tool="antismash"
                     /translation="AFFGHSFGGRTAYELAH"
     gene            complement(3567..3860)
                     /locus_tag="F7P10_RS09600"
                     /old_locus_tag="F7P10_09600"
     CDS             complement(3567..3860)
                     /NRPS_PKS="Domain: PP-binding (25-84). E-value: 6.3e-15.
                     Score: 47.2. Matches aSDomain:
                     nrpspksdomains_F7P10_RS09600_PP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012759.4"
                     /locus_tag="F7P10_RS09600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_09600"
                     /product="phosphopantetheine-binding protein"
                     /protein_id="WP_176611378.1"
                     /sec_met_domain="PP-binding (E-value: 7.7e-12, bitscore:
                     44.5, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSGDAVRGDNVRGDAGRLRDWVLGTCQDLGLPLRHDEDDFFEAGG
                     TSLSAAKLIGRAEEEFGEDALPPEALFEGSTVGELVATLARHVPATARDREG"
     aSDomain        complement(3609..3785)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_F7P10_RS09600_PP-binding.1"
                     /evalue="6.30E-15"
                     /label="F7P10_RS09600_PP-binding.1"
                     /locus_tag="F7P10_RS09600"
                     /protein_end="84"
                     /protein_start="25"
                     /score="47.2"
                     /tool="antismash"
                     /translation="CQDLGLPLRHDEDDFFEAGGTSLSAAKLIGRAEEEFGEDALPPEA
                     LFEGSTVGELVATL"
     gene            complement(3857..4822)
                     /locus_tag="F7P10_RS09605"
                     /old_locus_tag="F7P10_09605"
     CDS             complement(3857..4822)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PhyH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR01762.1"
                     /locus_tag="F7P10_RS09605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_09605"
                     /product="chlorinating enzyme"
                     /protein_id="WP_151009025.1"
                     /sec_met_domain="PhyH (E-value: 2.9e-40, bitscore: 137.7,
                     seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNQQKPDFSLSADELAQFQRDGYLGPFDLYAPDEMERNLRALRPK
                     LLNTKTSVYVEDQAVSGSTNLANYDRHLDVDFLAEHITRPEIVDRVASILGPDVLCWRS
                     EFFPKYPGDEGTDWHQADNFSNVAGAKHPQIVWPEDAEFGGTVTVWTAFTEASVDTGCL
                     QFIPGSHKTMNYDESKVMTYDAEAINKVDKNGVRRGFFGYDYRQLQKDPDWSPDETKAV
                     SQVMRQGQFVIFWSTLMHASHPHSGKTGTMRLGYAGRYLPTSVRVYPYSDRLEEFGGSV
                     SLEKFGNVLVSGRDVFGHNRFADATRSGRPFEARRTGAHA"
     gene            complement(4819..6252)
                     /locus_tag="F7P10_RS09610"
                     /old_locus_tag="F7P10_09610"
     CDS             complement(4819..6252)
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (135-410). E-value:
                     4.5e-18. Score: 57.4. Matches aSDomain:
                     nrpspksdomains_F7P10_RS09610_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019: aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012382.4"
                     /locus_tag="F7P10_RS09610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_09610"
                     /product="PLP-dependent aminotransferase family protein"
                     /protein_id="WP_218040444.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 6.3e-16, bitscore:
                     57.4, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPATGGSNMLEISLDHEDSLSPPRQIYRQIRLAIMAGGLCDGDAL
                     PSVAELARHLDVAEGAVGAAYGWMSAEGFVELHQGGPRIRVGVRETRPPGRPAAPIELW
                     ADLPKPPARPGAAPEYDFRTGIPDRHLFPTETWRHLLAEQLAAMPSQSLVYEDPRGNAD
                     LRTEIAAHLRRVRDVRATAADVLVTNGSQQAVHLAARVLLRPGDRVAVENPGYPPPRQM
                     FASLGAEPVGVRVDAEGVVVAEIPDDCRLVYVTPSHQFPLGTPMSLRRKLDLLAWARRR
                     GAVIVEDDYDSELTFTDRPLEPLRAMAADHVLYVGSFSKVLLPMLRLGHMVAPAALRPA
                     LAKAKYLTDVGTPSVEQAALARFLAGGGFADHLRTVHGEYGARREVLIDVLARDFGDVL
                     TLVPAEAGLHVTVRAERDMWPLVLAARRAGIWLYSLGDFTDPPNSAHGLLFGYGAVPVD
                     AIEPGLRKLREIHDRKGRK"
     aSDomain        complement(5023..5847)
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_F7P10_RS09610_Aminotran_1_2.1"
                     /evalue="4.50E-18"
                     /label="F7P10_RS09610_Aminotran_1_2.1"
                     /locus_tag="F7P10_RS09610"
                     /protein_end="410"
                     /protein_start="135"
                     /score="57.4"
                     /tool="antismash"
                     /translation="TWRHLLAEQLAAMPSQSLVYEDPRGNADLRTEIAAHLRRVRDVRA
                     TAADVLVTNGSQQAVHLAARVLLRPGDRVAVENPGYPPPRQMFASLGAEPVGVRVDAEG
                     VVVAEIPDDCRLVYVTPSHQFPLGTPMSLRRKLDLLAWARRRGAVIVEDDYDSELTFTD
                     RPLEPLRAMAADHVLYVGSFSKVLLPMLRLGHMVAPAALRPALAKAKYLTDVGTPSVEQ
                     AALARFLAGGGFADHLRTVHGEYGARREVLIDVLARDFGDVLTLVPAEAGLHV"
     misc_feature    complement(6136..6138)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(6352..6367)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.13"
                     /tool="antismash"
     gene            complement(6515..6781)
                     /locus_tag="F7P10_RS09615"
                     /old_locus_tag="F7P10_09615"
     CDS             complement(6515..6781)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="F7P10_RS09615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="F7P10_09615"
                     /product="hypothetical protein"
                     /protein_id="WP_176611379.1"
                     /transl_table=11
                     /translation="MARRDDFPACEAVRLGAAVRRAWSSSPVTAYLDVDHPGVLGSWTG
                     DEREWRAVPQRASRADAAEAGLRTEPGPERYRLGASCGNGSRT"
     misc_feature    7383..7397
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.32"
                     /tool="antismash"
     misc_feature    complement(7386..7402)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 17.46"
                     /tool="antismash"
     gene            7709..8707
                     /locus_tag="F7P10_RS09620"
                     /old_locus_tag="F7P10_09620"
     CDS             7709..8707
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024248.4"
                     /locus_tag="F7P10_RS09620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_09620"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_176611380.1"
                     /transl_table=11
                     /translation="MLHIRFTGHDLARTRLSGAHPLWETVLSVRALRTRSGRGMLDGWR
                     ARTRARLPRSSRILMALCPAEGPFAEFLMRGGEDQGWNESIEAIVSTPGDRLARELSAL
                     PRLPVHAEPLAAGDPAALRELGDALRDYRCAAITPYWDRIQSRIDVERSFRLRTVARGG
                     VELLLSTLSADTRWDAGVLEVRCPESRTVKLDGRGLVLAPSVFCGRRPVLLENRDGHGP
                     AVLFFPTFTDFGAALHDHPCERPDALSALLGTTRAAALCGAADGTTTTELARRLGVTPA
                     TASEHAKVLREAGLITTGRVGRQAVHAITPLGVALSRRPVPASPQRVRPVP"
     gene            complement(8634..9152)
                     /locus_tag="F7P10_RS09625"
                     /old_locus_tag="F7P10_09625"
     CDS             complement(8634..9152)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="F7P10_RS09625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="F7P10_09625"
                     /product="hypothetical protein"
                     /protein_id="WP_151009027.1"
                     /transl_table=11
                     /translation="MTFETTADLVCWTALVLLALALVRVNRRLRAVEARVPEPGLPAGT
                     RAPGLDRLGVAPAGPTLLLFLSSGCGGCPAVLEEAVALAADPASVPMRAVFSGDGLPVD
                     DGLIPVHTGERELMSAYRVPGTPFAVLVESGRVRRAVPVRSLDLLKELAAPAAAKPARD
                     GGTGRRPAA"
     gene            complement(9187..9717)
                     /locus_tag="F7P10_RS09630"
                     /old_locus_tag="F7P10_09630"
     CDS             complement(9187..9717)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_process="GO:0030416 - methylamine metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF018942.4"
                     /locus_tag="F7P10_RS09630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_09630"
                     /product="MauE/DoxX family redox-associated membrane
                     protein"
                     /protein_id="WP_151009028.1"
                     /transl_table=11
                     /translation="MAMMIGATAASLVVLVLTAGAVGHALRPSVLTGALHAQGTVAPRL
                     IGPLAAAVPAAEAVPAVLAAHALLADRPGQLRVAMAAGAALLCGYAAYGLVVARTRRDV
                     PCGCSAAGTPMNGWVVARAAALAAAAGWAVAAAGPAAAATGGRAGVAALAGAVFAILLW
                     ELPALPSAAAPAR"
     misc_feature    9782..9795
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 12.75"
                     /tool="antismash"
     gene            10001..12622
                     /gene="lanKC"
                     /locus_tag="F7P10_RS09635"
                     /old_locus_tag="F7P10_09635"
     CDS             10001..12622
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF038151.1"
                     /locus_tag="F7P10_RS09635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_09635"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_151009029.1"
                     /sec_met_domain="micKC (E-value: 7e-245, bitscore: 813.9,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 1.3e-10, bitscore: 40.0,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 1.8e-07, bitscore:
                     29.2, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDLRYHAYGMVDPVFYDAPSTEVPGEDDGFSAGRQVPDGWTRQPR
                     GVWTMQGRTDGSIPDQGWKIHVSAGLHNAEEILDIVAKYCVEHDVFFKYLRSRRVLLAR
                     NSKYAERGGSGKFMTIYPADERVLEQTLRELGGMLEGQRAPYILSDLRWGSGPLFVRYG
                     GFRERSCRSEYGEPVPAIETPDGRLVPDHRDPVFRVPDWVTVPACLEPALAARDTGTPD
                     DFPFEIHKALHFSNGGGLYRATDTRTGGEVLVKEARPMAGLDRDEDDAVVRLDRERRFL
                     ERMADLDCIPRMVDHRVCWEHHFLVREFVAGETLSHHMVRRNPLLHVGATADEIAGYAA
                     WALDILEQIELALDELHRRGAVFGDLHPGNIIVRDDDTIAFVDFELVADAAQATRPALG
                     APGYQAPPGYTGVAVDRYALGCIRLAVFMSLTAVLRWDDGKVEQFIEFVTGRFPLPADY
                     AGKVRADIRSGTPSGRPDGGPPGASALWPEPAPASWDRLRDSIAGAILSAATPHRTDRL
                     FPGDIEQFATSNGGIGFGHGAAGVLWALAESGAGRFPEHEDWLVRAVGSVQRPPPGFFD
                     GVAGVAYALDRLGRRAEALEIMEHAPEPDAAVDRSLFRGLAGIGLNQLHFARSSGDRSY
                     AEAARATAERLVRDLDRPQDGLYRAGLMYGSSGPALFLIRLFEATGDRSLLDHAERALR
                     RDLDACKWTQKDRTLQVDEGWRVLPYVATGSAGIGLVLHEYLRHRAEPEFQEAQEGVRR
                     AAEPHYFVQSGLFNGRAGILAYLLHTGAGPGDPAVRRHLRNIGWHAVPFPGRESDQEPE
                     RDAERDAGGAPERIAFIGDQLLRLSMDLATGSAGVLLTLGAALSGRPLELPFLSPAEGA
                     DR"
     gene            12619..12789
                     /locus_tag="F7P10_RS09640"
                     /old_locus_tag="F7P10_09640"
     CDS             12619..12789
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF033212.1"
                     /locus_tag="F7P10_RS09640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_09640"
                     /product="SapB/AmfS family lanthipeptide"
                     /protein_id="WP_151009030.1"
                     /transl_table=11
                     /translation="MTILDTAKEVNTDMASILELQNLDVERADSAAAADSNGSVWECCS
                     TGSWVPFTCGC"
     CDS_motif       12619..12720
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MTILDTAKEVNTDMASILELQNLDVERADSAAAA"
                     /locus_tag="F7P10_RS09640_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       12721..12789
                     /prepeptide="core"
                     /locus_tag="F7P10_RS09640_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="16.30"
                     /molecular_weight="2233.4"
                     /monoisotopic_mass="2231.9"
                     /core_sequence="DSNGSVWECCSTGSWVPFTCGC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MTILDTAKEVNTDMASILELQNLDVERADSAAAA"
                     /leader_location="[12618:12720](+)"
                     /alternative_weights="2251.4"
                     /alternative_weights="2269.5"
     CDS             12855..12980
                     /gene="allorf_2197860_2197985"
                     /locus_tag="allorf_2197860_2197985"
                     /protein_id="allorf_2197860_2197985"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MKPKMAKILELQSLHVEHASGARSDFSWWECCSQGSLFNCC"
     CDS_motif       12855..12923
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MKPKMAKILELQSLHVEHASGAR"
                     /locus_tag="allorf_2197860_2197985_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       12924..12980
                     /prepeptide="core"
                     /locus_tag="allorf_2197860_2197985_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="17.10"
                     /molecular_weight="2046.2"
                     /monoisotopic_mass="2044.7"
                     /core_sequence="SDFSWWECCSQGSLFNCC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKPKMAKILELQSLHVEHASGAR"
                     /leader_location="[12854:12923](+)"
     misc_feature    12866..12881
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.19"
                     /tool="antismash"
     gene            13076..14782
                     /locus_tag="F7P10_RS09645"
                     /old_locus_tag="F7P10_09645"
     CDS             13076..14782
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012869.4"
                     /locus_tag="F7P10_RS09645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_09645"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_254716516.1"
                     /transl_table=11
                     /translation="MRRVRGRGRMAPLVAAALAGVGCTVALPAVLGAATEAVLAGGDAR
                     VPLSVLVALLAAAVAAAYALKVAEVACMSAETVRLRSRLIEHVLALGVPGERAFAPGDL
                     ASRVVTGASRAAGAAPVLVQLVAGLATSLGGVAALWLIDWRLVATVALAVPAGLAMMRI
                     FVRHASGLVARYQELQGEISTRMLDALAGIRTVRGAGTWRREADRILAPLPELAVSGRD
                     LWRAYGRIQGQGTLLVPLTGLAALAVAGQGVLAGRISPGQMLAVAGYAPMALGLLGQVS
                     MLLGLARLRAGEQRIDEVLSVPVPERGRRPLPDGPGELRLRGVTVHGTDGPLLEAVDLA
                     VPAGRSVAIVGRSGAGKTTLAMVAGGLLEPDAGRVLLDGVPLAEADPASLRRAVAYAFE
                     RPRLRGASVADAIGYGCGTPPRERIEGAAALAGADRFVRLLPGGYDTPLREAPMSGGEE
                     QRLGLARAFVRPARLLVLDDATSSLDSVTEAQVAAALARAAAGRTRLVVAHRAGTAARA
                     DLVAWLDGGAVRAVGPHRELWRERAYRELFEPPAPASRPGGTGSARDEGAP"
     gene            14779..16611
                     /locus_tag="F7P10_RS09650"
                     /old_locus_tag="F7P10_09650"
     CDS             14779..16611
                     /EC_number="7.-.-.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.4"
                     /locus_tag="F7P10_RS09650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_09650"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_151009031.1"
                     /transl_table=11
                     /translation="MTAPNTPDTPDVPADAVPGLGRRAWRRPLAELVRERRGLAVTLAW
                     SLAATLPALLSGQLVARSLDHGFLRDDLAAGLGWLAVLGAAMVVAAASARRVPPALGRV
                     VEPLRDRLVRRVVTGTLRRAVGAGPGRPGMSVITRMSEHTETVRDTTAGLLLGMQQVGL
                     TVTAAAVGLALLAPVVALLVVPPVVLTLLLLVRLLPELAARERTSLLAEERVADTVSGV
                     VSGVRDVVACGAAAEAAGEAAGVFRAQAAAERAAARASALRTALGTAGGHLSLVMVLAA
                     GPWLLHGGGLTTGELLGALTYVTANLQPALRAAVQTAGGAAVRLGVTLHRLESCAGPEP
                     ESRPDAAPASGTGVPDGCELRVDRLTFAYGTGAEPVLRDVTFAVPYGSHLAVVGPSGIG
                     KSTLADLLTGVAEPARGTVSIGGLPLGAVDPGWLRRTIAIIPQEAYVFAGSLRENLAYL
                     RPAATEAEIEDAVTALGLGPLRDRLGGAEAAIGSSSGLTPGERQMIALARVWLSPARIV
                     LLDEATCHLDPVTEARMEEAFRARPGTLVVIAHRLSSARRADRVLVMDGERTVLGRHDE
                     LPRRSGLYADLVGAWQAGRQEDERRDGARVDQPH"
     misc_feature    complement(16620..16633)
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 18.48"
                     /tool="antismash"
     gene            16687..17874
                     /locus_tag="F7P10_RS09655"
                     /old_locus_tag="F7P10_09655"
     CDS             16687..17874
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012296.4"
                     /locus_tag="F7P10_RS09655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_09655"
                     /product="cytochrome P450"
                     /protein_id="WP_151009032.1"
                     /sec_met_domain="p450 (E-value: 6.1e-25, bitscore: 86.8,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAPVYWDPYDPRFWQDPYPTYGRLREEAPLYYNEKHDFYAVTRF
                     ADVERGLPDWRTFSSARGGILELIKSGIEIPPGTLIFEDPDIHDVHRRLLARVFTPRRI
                     AELEPRVRDFCVRTLDPLVGATEFDLIREVGVQMPMRVIGMLLGIPEADQEAIRDSADE
                     ALRTEPGGQMDHADGSHFSNEMFREYIEWRAKNPSDDLMTVLLNTEFEDEDGTTRTLTH
                     DEALTYTTVVAGAGNETTGRLIGWLGSVLAQHPDQRRALVDDPSLIPGAIEETLRYEPP
                     GPSIARYVTRDVEFHGRTVPEGSAMLFIVAAANRDENRYPDPDRFDVRRGMSQQLTFGL
                     GVHYCLGAALARLEGRVALEEMLKRFPEWDVDWDGAKLAQTTTVRGWETLPLTIG"
     gene            17934..19394
                     /locus_tag="F7P10_RS09660"
                     /old_locus_tag="F7P10_09660"
     CDS             17934..19394
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /NRPS_PKS="Domain: AMP-binding (15-388). E-value: 8e-72.
                     Score: 234.0. Matches aSDomain:
                     nrpspksdomains_F7P10_RS09660_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012711.4"
                     /locus_tag="F7P10_RS09660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_09660"
                     /product="class I adenylate-forming enzyme family protein"
                     /protein_id="WP_151009033.1"
                     /sec_met_domain="AMP-binding (E-value: 1.9e-59, bitscore:
                     200.2, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHGTETSQARRIALLAKERPDWPAYLHVRADGTEEAVTCARLDDR
                     AGRLAGAFAERGVGHGDLVGLGLRNSPRFAMSVFAAWKLGAVPVPVRWDVPDWELERLK
                     RVIDPRLYLGPDDLDWIDASAARPVPELPDVVSPHMQGICSSGSTGTPKIILSAAPAVH
                     NPVLSTPMAEAWMPVPRPQTVLVLAPMYHVNAFATLYSLVDGDRLVVMEKFDAALALEL
                     IERHRVTTFTATPTMLQRMADAPGADDRDLSSLVWLQQGAAPMPPSLVHRWAELIGPER
                     IVMAYGMTEALGITALRGDEWMLHQGSVGRGLRGTEVRILDADGRDLPPGELGEIFLRA
                     PSYGGSTYLGQAPRLAETPDGFRAVGDMGYLDGDGYLYLVDRRVDMITSGGANVFPAEV
                     EAALIDHPEIADVVVIGLRDAEWGRRVHALVQPADPAAPPTAAEVVAYAKGRLAPYKVP
                     KTVELVDAIPRSAATKVNRGRLVEARGG"
     aSDomain        17979..19097
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_F7P10_RS09660_AMP-binding.1"
                     /evalue="8.00E-72"
                     /label="F7P10_RS09660_AMP-binding.1"
                     /locus_tag="F7P10_RS09660"
                     /protein_end="388"
                     /protein_start="15"
                     /score="234.0"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="AKERPDWPAYLHVRADGTEEAVTCARLDDRAGRLAGAFAERGVGH
                     GDLVGLGLRNSPRFAMSVFAAWKLGAVPVPVRWDVPDWELERLKRVIDPRLYLGPDDLD
                     WIDASAARPVPELPDVVSPHMQGICSSGSTGTPKIILSAAPAVHNPVLSTPMAEAWMPV
                     PRPQTVLVLAPMYHVNAFATLYSLVDGDRLVVMEKFDAALALELIERHRVTTFTATPTM
                     LQRMADAPGADDRDLSSLVWLQQGAAPMPPSLVHRWAELIGPERIVMAYGMTEALGITA
                     LRGDEWMLHQGSVGRGLRGTEVRILDADGRDLPPGELGEIFLRAPSYGGSTYLGQAPRL
                     AETPDGFRAVGDMGYLDGDGYLYLVDRRVDMIT"
     CDS_motif       18360..18398
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_F7P10_RS09660_0001"
                     /evalue="3.90E-03"
                     /label="NRPS-A_a3"
                     /locus_tag="F7P10_RS09660"
                     /protein_end="155"
                     /protein_start="142"
                     /score="10.4"
                     /tool="antismash"
                     /translation="ICSSGSTGTPKII"
     gene            complement(19412..20479)
                     /locus_tag="F7P10_RS09665"
                     /old_locus_tag="F7P10_09665"
     CDS             complement(19412..20479)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040257.3"
                     /locus_tag="F7P10_RS09665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_09665"
                     /product="hypothetical protein"
                     /protein_id="WP_218040445.1"
                     /transl_table=11
                     /translation="MEPISDRPVRVVQWTTGNVARQSLRAVVERPELELVGLYAFSGDK
                     VGRDAGELAGLGRTVGVTATNDIDEIIALAPDCVLYMPLHPDVEHLTRLLRAGVNVLST
                     ASFLTGRAYGEEARAALDDAARAGGASLFGSGVNPGYADQLAAVASGVCREVEYVTVFE
                     SFDIGMWAGDANQDELGWGRPAGDPGHADDVVRATAPFGDAVEALAELLGTSIDDVRCE
                     VGFAHATKDLDLPGRPVGRGTVAGLDVRWIGVSGGADAVEAHIRWTVTSELDPAWEVAM
                     AYLIEVRGHPQVNLRVEVLPQDMASMSLEDMLAIGSVITAMPVVNAVPAVVAARPGIVT
                     YADLPTQASRHVRRP"
     misc_feature    complement(20533..20544)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 16.22"
                     /tool="antismash"
     gene            complement(20612..21217)
                     /locus_tag="F7P10_RS09670"
                     /old_locus_tag="F7P10_09670"
     CDS             complement(20612..21217)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012655.4"
                     /locus_tag="F7P10_RS09670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_09670"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_218040446.1"
                     /transl_table=11
                     /translation="MEKRRALLQAAIALWRTNGFAGTTVADICKAAGVSKALFYFYFPT
                     KEDALAEAGVLSTGDARRVARARRAGPGELPEAIGAVLAALERSMRHSPPDLLIEATLE
                     GHRAEHRALREGRPDEHHASRYLFLELLRRAQRDGGLPPGLDVLHVARGVQALLEAGTR
                     HWAAGEYGDRGFAEVVGRDIAAFVAGHARIASGDAQES"
     misc_feature    complement(21720..21735)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.59"
                     /tool="antismash"
ORIGIN
        1 ccatcatcag ctgccggttg tacttcatca ccgggcactg gcccgtggcg aaggactgcg
       61 acttggccca gccgagcccg aagtccagcc cgagccgtcc ggctcgggcg ttctcgtcgg
      121 cggcccccgg atcgccggtg acgtacagtc cggggatgcc gacccctccg gcggctcggg
      181 taactcccat cagggtgttg aggacggtcg ccggccgttc cacgcccgcc ccttcggggc
      241 cgtggccgcg cgcctcgaag ccgacgcagt cgacggccgc gtcgacctcc gggacgccga
      301 ggatctcctc gatctgctcg gcgacgtccg cgtggccggc caggtcgatc gtctcgcagc
      361 cgaagccgcg cgcctgctcc agccgccgcg ggttcatgtc cccgacgatc acgacggcgg
      421 cgcccagcag caggcaggcg gtcgcgcagg ccaggccgac cgggccggcc ccggcgacgt
      481 acacggtcga gccggtggtc acgcccgccg tgacggcgcc gtggtagccg gtcgggaaga
      541 tgtccgacag catcgccaga tcccgcagct tggccatcac ggtgtcgcgg tcggcgggga
      601 acttcagcag gttgaaatcg gcgtacggga cgaccgcgta ctccgcctgg ccgccgtgcc
      661 agccgcccat gtcgacgtag ccgtacgccg cgcccggccg ctcccggttg acgttctcgc
      721 acacgccggt gttgcgctcc ttgcagttgc ggcagcggcc gcaggcgatg ttgaacggga
      781 cgctgaccag gtctccccgc tcgacgaact ccacgtccct gccgagctcg atcacctcgc
      841 cggtgatctc gtggccgagc gtgagccccg ccggcgcggt cgtccggccc cgcaccatgt
      901 gctggtcgga gccgcagatg ttggtggcca gcaccttgag gatgaccccg tgctccagct
      961 tgcggccgcc ctgttcggcg agttccaggc gcgggaactc caggtcctcg acctggaccg
     1021 tgcccggccc ttcgtacacc acgcctcggt tcgtgttcgg cacgacctct ccccccatcg
     1081 agagtccggc tcgcgcacgc ccgcgacggg gcccgtttcc gtcacccccg ccgcgcgggc
     1141 gtcgcggctt cacgtcacac gacagagaca tacccgtttc gttgccatta gtccgtttcg
     1201 tcggggttgg ggtggggtcg atccggcgcg gtcaccggcg cgccggtcgc gcgttcgtga
     1261 agggtcagca gggcgcgccg gtcgaccttc ccgttcgccg acagcggcag cgcggcgcag
     1321 aagtggatca ccgaggggat caggtatttc gggagttccg ccctcaggtg ctcgcgaacc
     1381 gacgccgccg tgcacgcctc gtgctccggg acgacgaagg cgaccagggt cctctccccc
     1441 gccgccgtcg cgccgaccac gacgtggctc tgccggacgt gcgggtgccg gttgaggtgg
     1501 tggacgacct cgccgggctc gatgcggtgc ccgttgatct tcacctggtc gtccagccgc
     1561 cccaggaaca cgacggcccc gtcgggccgg aagcggcccc ggtcgccggt gcggtacagc
     1621 cgttcccggc gcccgccgat gtcgcgctcg acgaaccgct cgcgggtcgc ggcggggttc
     1681 gcgaggtagc cgggcgagag gcccggcccg gcgagccaga cctcccccgt ctcccccgcc
     1741 ccgcagagcc ggtcgccgtc gacgaggtag aggcgcgtgt tctggatcgg cgtgccgatc
     1801 ggcaacggcg agccgtccgg gtccagcgcc cgcaccgggt ggtaggtggc gaaggtcgtg
     1861 ctctcggtcg ggccgtaggc gttgacgatc cggtccggac cgtagtgccg cagtgcggcg
     1921 gcgatgtgcc gcagcgaatg cgcctcgccg ccggtgagga tcgtcccgac gctcgcgagc
     1981 gtcgcgggcg cctcgtccac gatcgtgttg aacagcgccg ccgtcagcca gacgacggtg
     2041 acgcgctgcg cctccagcac cttcctcagc tcggagaacc gcaggaaggc ggacgggtac
     2101 aggacgcacg tgcccccgtt cagcagcgcg ccccagatct cgaaggtggc cgcgtcgaag
     2161 gagatcggcg ccagctggag cagccgggcg tgctcgtcga gccgcgcgta gcgggcggca
     2221 tggacgagcc ggacgatgct ccggtggcgg atcggaacgc ccttgggcgt ccccgtcgag
     2281 cccgaggtga agttgatgta ggcgatgtcg tcggggtccg cccgcaccgc cggagccgcc
     2341 ccggacaccg caccgcccgc cgcaccgtcc gcgggcacga accgctgctc gggcaggcgg
     2401 gcgcgcagtg ccgggggccg gtcggtcacg acgacgccgc agcgggcccg gccgaggacg
     2461 aggcgcagcc gtccgtccgg ccagtccggg tcgaagggga ggtaggcggc accgcacttg
     2521 agcaccgcga gcagcgcggc gatcagctcg ggcgaccggg cgcagcacac gccgacgacg
     2581 tcgccgcggc cgaccccggc ctcgtgcagg cgggcggcga ggccgtcggc gaggaggtcg
     2641 agctcccggt aactgagggt gcgttcgcgg tgcacgacgg cggtcgcgtc cggggtgcgg
     2701 acggcctgcc gctcgaacag cgccgcgacc ccgcggtcgt cgggatactc cacggcggtc
     2761 cggttgatcc gatcatgaat ggccagcgcc ccgggggcgg ccaccagccg tcgcacctga
     2821 cgtccccaat ctctcgttga tcacgtccag gacgagcccg cggtggctgt cgacgaagaa
     2881 gtgcgcgccc ggcagctcga ccagctcgca cccgcggccg ccgaacgcgg gccagtccgc
     2941 catcgccgcg agcgggtcga tcgggtcgtc ccgcccgtag agcaccgtca gcggcacgtc
     3001 cagcggcgtc gccgcgcggt cgtcccacag ctcggcgagc cggaggtcgc tgcgcacggc
     3061 gggcacgagc atccgcatca gcggttcgct ggcgagcagg tcctcgggca tgccgcccat
     3121 gtcccgcagc gccgcccgga actccgcgtc gggcagcgga tggaggtggg ggcggcggtg
     3181 ccggttcggg ctccggcagc cggacacgaa cagccgcacg gtgcggccgg ggtgctcggc
     3241 cgcggcgagg tgcgccagct cgtaggccgt cctgccgccg aaactgtgcc cgaagaacgc
     3301 gtgcggtgcg tccaggagcg gggccagcgc ggcggaggcg cgcgccagca gggtcgccca
     3361 gtcggcgcac gacggttcct tgatccgcga gccccggccg gggagcctga ccgccaccag
     3421 cccgacgttg tcgtccagcg cgtccgccca ggagcggaac agggcggggt tcccgcccgc
     3481 gtacgggacg cagatcaggg tgacggccgg ctcgcgcgac gcccgcttga gccgcagcag
     3541 ccacgggtcg ccgtcaggcg gcacggtcag ccctcccggt cgcgggccgt cgccggaacg
     3601 tgccgggcca gggtggccac gagctcgccc accgtgctgc cctcgaacag cgcctcgggc
     3661 ggcagcgcgt cctcgccgaa ctcctcctcc gcgcgtccga tcagcttcgc ggccgacagc
     3721 gacgtgccgc ccgcctcgaa gaagtcgtcc tcgtcgtgcc ggagcgggag ccccaggtcc
     3781 tggcacgttc cgagaaccca gtcgcgcagc cgtcccgcgt ccccgcgcac gttgtccccg
     3841 cgcacggcgt ccccgctcac gcgtgcgctc ccgtccggcg cgcctcgaac ggccggcccg
     3901 accgggtcgc gtccgcgaac ctgttgtgcc cgaacacgtc ccggccggac accagcacgt
     3961 tgccgaactt ctccaggctc accgaacccc cgaactcctc cagccggtcg gagtaggggt
     4021 agacgcggac ggaggtgggc aggtaccggc ccgcgtagcc gagccgcatc gtgccggtct
     4081 tcccgctgtg cgggtgggag gcgtgcatga gcgtggacca gaagatgacg aactggcctt
     4141 ggcgcatcac ctgcgagacc gccttcgtct catccgggct ccagtcggga tctttctgca
     4201 gctgccggta gtcgtagccg aagaagccgc gccggacccc gttcttgtcg accttgttga
     4261 tggcctcggc gtcgtacgtc atgaccttgg actcgtcata gttcatggtc ttgtgcgagc
     4321 cgggaatgaa ctgcaggcag ccggtgtcga cgctcgcttc ggtgaacgcc gtccagacgg
     4381 tgacggtgcc gccgaactcg gcgtcctcgg gccagacgat ctgcggatgc ttggcgcccg
     4441 cgacattgga gaagttgtcg gcctggtgcc agtcggttcc ctcgtcgccc gggtatttgg
     4501 ggaagaactc gctgcgccag cacagcacgt ccggaccgag aatgctcgcg acgcggtcga
     4561 cgatctcggg ccgggtgatg tgctcggcca gaaaatcgac gtcgagatgg cggtcgtagt
     4621 tggcgaggtt ggtgctcccg gagaccgcct gatcctcgac gtagacggag gtcttcgtat
     4681 tgagcagttt gggacgcagg gcacgcaggt tgcgctccat ctcgtccggc gcgtagaggt
     4741 cgaacggccc gaggtagccg tcccgctgga actgcgccaa ctcgtcggcg ctcagcgaga
     4801 agtcgggttt ctgctggttc atttcctgcc cttccggtcg tggatctctc gcagtttccg
     4861 gagtcccggc tcgatcgcgt cgaccggcac cgctccgtag ccgaacagca gcccgtgcgc
     4921 ggagttcggc gggtccgtga agtcgccgag cgagtacagc cagatccccg cccggcgcgc
     4981 ggccagcacg agcggccaca tgtcccgctc ggcgcggacg gtcacgtgca gcccggcctc
     5041 cgccggcacg agcgtcagga cgtcgccgaa gtcgcgcgcg aggacgtcga tcagcacctc
     5101 gcgccgggct ccgtactcgc cgtgcaccgt gcgcaggtga tcagcgaatc cgccgccggc
     5161 caggaaccgc gccagcgcgg cctgctccac gctcggggtg ccgacgtccg tgaggtactt
     5221 cgccttcgcc agcgctggcc gcagcgcggc cggggcgacc atgtgcccga gccgcagcat
     5281 cggcagcagc accttggaga acgagccgac gtagagcacg tggtcggcag ccatcgcgcg
     5341 cagcggttcc agcggccggt cggtgaaggt cagctcgctg tcgtagtcgt cctccacgat
     5401 caccgcgccg cgccgccgcg cccacgccag caggtccagc ttgcggcgca gcgacatcgg
     5461 cgtgcccagc gggaactggt gcgacggggt gacgtagacg agccggcagt cgtccgggat
     5521 ctcggccacg acgacgccct ccgcgtcgac ccggaccccg acgggctcgg ctcccaggct
     5581 cgcgaacatc tgccgcggcg gcgggtagcc cgggttctcg acggcgaccc ggtcgcccgg
     5641 ccgcagcagc acgcgggccg cgaggtgcac cgcctgctgc gatccgttgg tgacgaggac
     5701 gtccgccgcc gtcgcgcgga cgtcccggac ccgccgcagg tgcgcggcga tctccgtccg
     5761 caggtcggcg tttccgcgcg gatcctcgta gaccagcgac tgggacggca tcgcggccag
     5821 ttgctccgcc agcaggtgcc gccaggtttc cgtcgggaac aggtgcctgt ccggtatccc
     5881 ggtgcggaag tcgtattcgg gcgccgcgcc gggccgcgcc ggcggtttcg gcaggtccgc
     5941 ccagagttcg atcggcgccg cgggccgccc gggcggccgc gtttcccgca cgccgacgcg
     6001 aatgcgcggc ccgccctggt gcaactccac gaaaccttcg gcgctcatcc acccgtaggc
     6061 cgcaccgacc gcgccttccg cgacgtcaag gtgccgcgcc aactccgcca ccgatggcag
     6121 cgcgtcaccg tcgcataagc cgcccgccat aattgcgaga cggatctgcc ggtatatttg
     6181 acggggcggg gacagggaat cctcgtggtc gaggctgatc tccagcatgt tcgagccgcc
     6241 agtcgcaggc atgacgaacc ggacttggat cggtccgtta tctacgggtg ggattacttg
     6301 cggggttcgg ccgtgtcagg caggactcta ctccgtactc gaccgttgcg atgtgatcta
     6361 tatcaccttg cagtcacgca caactcggtg gagatcaccg gcttccgcac acgccccctc
     6421 cgcacccccc gccgaccggc tcacaagttg atctccatgc gattccggcg atggattttc
     6481 tgccgacatc gcgttcttgc agtacagggg cgactcatgt gcgactgcca ttaccgcagg
     6541 aagcaccgag ccgataccgc tcggggcccg gttcagtccg gagcccggcc tcggccgcgt
     6601 ccgcccgcga ggcccgctgc gggacggccc gccattcccg ctcgtccccc gtccaggagc
     6661 cgaggacgcc cggatggtcg acgtcgaggt acgccgtgac cggcgacgac gaccacgcgc
     6721 ggcgcacggc ggcgcccagc cggacggcct cgcaggcggg aaagtcgtcg cgtcgcgcca
     6781 cagcgccggc tccaccggac ggtcggcggt gccgagttcg gctttcgccg ccgaccgcgg
     6841 gcggcggacc cacggccgga cgggcagtcc cgctgaaggg aagcagcggc gcggtggcac
     6901 cggattccgt tcgctcgttg ccgccgcatg cggggaacga tgcgcaggcg cgccgcccgg
     6961 cgggcggggc ggcgccattc cacccgacgt cgctcgggcg gccgagaaaa tgccggcggc
     7021 gccttcagcg gaccggcgcc cagttcggac ggtgccttcg ggggacgatc ggcacatagc
     7081 agaacagtgc cgcacgtgcc gcagaccgcg ccctacacaa agcggcgtcg acgacgataa
     7141 caattgcgcg tcccccacta gaagagtcga cagaatagtg aaattcggcc gccgctccac
     7201 tacatctccc ggaacgcctc actcggaaac tcccgccccc cggcctccgc cgcccggccc
     7261 tgaagcccgc ggcggccgcg accgcaccac agggctgtca ccttgacggc agcggcgacc
     7321 ttgccgcacg cggccggcgc gccacccgtc ggcctcccct ccggccggga ggcgaagcgc
     7381 agcatatgca gacaaattac tgcgtcggaa cgggaccgaa aagatccttt cgcgcggcgg
     7441 acacatcgcg cggtagacga tcacctggcg ctccggcaag agcgcactgg aatgcaggcg
     7501 aacgaaatat ctcactccat gtcttgactg gcccgtagtc gtcaggttag acatgtcagg
     7561 caagtcaatg gcatgcccag gggatgcact tcatgccatt ggtcggggac cagcggggtg
     7621 tgcgttccgt gctgcgacat gtctttcggt cgtggtccct gtgtctcgcg ttgtcggaca
     7681 acggaggacg atgggatcgg gggaccccat gctgcacatt cgcttcaccg gtcatgatct
     7741 ggcgcgcacc aggctctccg gggcgcaccc gctatgggag accgtcctga gcgttcgggc
     7801 gctccggacg cggtccggcc gggggatgct cgacgggtgg cgcgcgcgga cgcgcgcccg
     7861 cctgccgcgg tcgagccgga tactgatggc gctgtgcccg gcggaaggac cgttcgcgga
     7921 attcctcatg cgcggcgggg aggaccaggg ctggaacgag agcatcgagg cgatcgtctc
     7981 gacgcccggc gatcggctgg cccgggagct ctccgcgttg ccgcggctcc cggtgcacgc
     8041 ggagcccctc gcggccgggg acccggcggc gctccgagaa ctcggcgatg cgctgcggga
     8101 ttaccggtgc gccgcgatca ccccttactg ggatcggatc cagagcagaa tcgacgtgga
     8161 gcgcagtttc cggctccgga cggtcgcccg aggcggcgtc gagctcctgc tgtcgactct
     8221 ctcggccgac acccgctggg acgccggtgt cctggaagtc cgatgtccgg agtcacggac
     8281 ggtcaagctg gacgggcgcg ggctggtgct ggcgccctcg gtgttctgcg gccgcaggcc
     8341 cgtcctcctg gagaaccggg acgggcatgg gcccgcggtg ctgttcttcc ccacgttcac
     8401 cgacttcggg gcggcactgc acgatcatcc gtgcgagcgg cccgacgcgc tctcggcact
     8461 gctggggacg acccgcgcgg ccgcgctctg cggggcggcg gacgggacga ccaccacgga
     8521 actggccagg cggctgggcg tcaccccggc cacggccagc gagcacgcga aggtcctccg
     8581 cgaggcgggc ctgatcacca ccggacgggt gggccggcag gcggtgcacg cgatcacgcc
     8641 gctgggcgtc gccctgtccc gccgtcccgt gccggcttcg ccgcagcggg tgcggccagt
     8701 tccttgagga ggtcgaggga gcggaccggc accgccctgc gcacccggcc ggactcgacg
     8761 agcacggcga acggcgtccc cggaacccgg taggcggaca tgagctcccg ctccccggtg
     8821 tgcacgggga tgagcccgtc gtccacgggg aggccgtcgc ccgagaacac cgcccgcatc
     8881 ggaacgctcg ccgggtcggc cgccagcgcc acggcctcct ccagaacggc ggggcagccg
     8941 ccgcagccgg agctgaggaa cagcagcagc gtcggcccgg ccggggcgac cccgagccgg
     9001 tcgagtccgg gcgccctcgt accggcgggc aggccgggct cgggaacgcg ggcctcgacg
     9061 gcgcgcagcc gccggttcac ccggacgagc gcgagggcca gcaggaccag ggccgtccag
     9121 cagaccaggt cggcggtcgt ctcgaacgtc atgtcggcgg tctccttccg gcctgcgcgc
     9181 cggtcctcac cgggccggcg cggcggcgga cggcagtgcg ggaagttccc acagcaggat
     9241 cgcgaacacg gccccggcca gtgccgccac gcccgcccgg ccgccggtcg cggcggcggc
     9301 cggaccggcc gccgccaccg cccatcccgc cgcggccgcc agcgcggcgg ccctggcgac
     9361 cacccatccg ttcatcggcg ttcccgcggc cgaacagccg cacgggacgt cccgccgggt
     9421 gcgggcgacc acgaggccgt aggcggcgta accgcacagc agcgccgcgc cggcggccat
     9481 cgcgacgcgc agctggccgg gccggtcggc gagcagggcg tgcgcggcca gcacggcggg
     9541 caccgcctcc gccgcgggca cggccgcggc cagcggaccg atcaggcgcg gcgcgacggt
     9601 tccctgcgcg tgcagcgccc cggtcaggac ggagggccgc agcgcgtggc ccacggcccc
     9661 ggcggtcagg acgagcacga ccagcgaggc cgccgtggcg ccgatcatca tggccatcgg
     9721 atcacatcgc atcacatcgc ttcgcgttgc ccgcccggaa agtgcgccgg tccccggcca
     9781 cttgaactat aaccacgcgg aagccggacg ggaatgtcga tcgtcggccg ccaaagtcgc
     9841 acgacggtcc cggcgacccc gctgaccggc acgttcaggt cagcgccgaa gcataattcg
     9901 tggacatttc ggagagcgcc gaagagagtc gccgtccggt cggcacatcg cccaccatgt
     9961 cggctatgcc gggacccccg ggtgctgatt ggagccatgc atggatcttc ggtatcacgc
    10021 gtacggaatg gtggatccgg tcttctatga cgcgccttcc accgaggttc ccggcgaaga
    10081 cgacggcttc tccgcaggca ggcaggtgcc ggacggctgg acgcgacagc cgagaggcgt
    10141 ctggacgatg caggggcgaa ccgacggatc gattcccgac cagggctgga agatccacgt
    10201 ttcggccgga ctgcacaatg ccgaagaaat tctggacatc gtcgcgaaat actgcgtcga
    10261 gcacgacgtc ttcttcaagt acctgcgcag ccgacgcgtg cttctggccc gcaacagcaa
    10321 gtacgccgaa cgcggcggaa gcggaaaatt catgacgatc tatcccgccg acgagcgggt
    10381 cctcgaacag acgctgcgtg aactcggcgg catgctcgaa gggcagcggg ccccctatat
    10441 cctgagcgat ctccgctggg gatccgggcc gctgttcgtg cgctacggcg gcttccggga
    10501 aaggtcgtgc cggtcggagt acggcgagcc ggtgccggcc atcgagacgc cggacggccg
    10561 gctcgtcccg gaccaccgcg atccggtctt ccgggttccg gactgggtca ccgtgcccgc
    10621 ctgcctcgag ccggcgctgg ccgcccgcga taccggcacg ccggacgact tcccgttcga
    10681 gatccacaag gcgctgcact tctccaacgg cgggggcctc taccgcgcca ccgacacccg
    10741 caccggcggg gaggtcctgg tcaaggaggc gcggccgatg gccgggctgg accgcgacga
    10801 ggacgacgcc gtcgtccggc tggaccggga acgccggttc ctcgagcgca tggccgacct
    10861 cgactgcatc ccccgcatgg tggaccaccg cgtctgctgg gagcaccact tcctcgtccg
    10921 cgagttcgtg gccggggaga ccctgtcgca ccacatggtg cgccgcaacc cgctgctgca
    10981 cgtcggcgcg accgccgacg agatcgccgg ctacgccgcc tgggcgctgg acatcctgga
    11041 gcagatcgag ctggcgctgg acgagctgca ccgccgcggt gccgtgttcg gtgacctgca
    11101 ccccggcaac atcatcgtgc gggacgacga cacgatcgcg ttcgtcgact tcgaactggt
    11161 cgccgacgcc gcgcaggcga cgcgtccggc gctgggcgcg cccggctacc aggccccgcc
    11221 cggctacacc ggcgtcgccg tcgaccggta cgcgctggga tgcatccggc tggccgtctt
    11281 catgtcgctg accgccgtcc tgcgctggga cgacggcaag gtcgagcagt tcatcgagtt
    11341 cgtcaccggg cgcttcccgc tgcccgccga ctacgccggc aaggtccgcg ccgacatccg
    11401 ctccggcacg ccgtccggac gcccggacgg cggcccgccc ggggcgagcg cgctgtggcc
    11461 ggagcccgcg cccgcgtcct gggaccggct ccgcgactcg atcgcgggcg cgatcctgtc
    11521 ggccgccacc ccgcaccgga ccgaccgcct gttccccggc gacatcgagc agttcgccac
    11581 ctccaacggg ggcatcgggt tcgggcacgg cgcggcgggc gtgctgtggg cgctggcgga
    11641 gagcggcgcc ggacggttcc ccgagcacga ggactggctg gtacgggccg tcggctcggt
    11701 gcagcggccc ccgcccggct tcttcgacgg cgtcgcgggg gtcgcgtacg cgctggaccg
    11761 gctcggccga cgcgccgagg ccctggagat catggagcac gcgcccgagc cggacgcggc
    11821 ggtggaccgc agcctgttcc gcgggctggc cgggatcggg ctcaaccagc tccatttcgc
    11881 gcggagcagc ggcgaccggt cgtacgccga ggcggcgcgg gcgaccgccg aacggctcgt
    11941 ccgcgacctc gaccgtccgc aggacggcct gtaccgggcc gggctgatgt acggctcgtc
    12001 cggtccggcg ctgttcctga tccggttgtt cgaggcgacc ggggaccgga gcctgctcga
    12061 ccacgccgag cgggcgctgc ggcgggacct ggacgcctgc aagtggacgc agaaggaccg
    12121 caccctccag gtggacgagg ggtggcgggt gcttccgtac gtcgccaccg gcagcgcggg
    12181 catcgggctc gtcctgcacg agtacctgcg ccatcgcgcg gagccggagt tccaggaggc
    12241 ccaggagggc gtccgccgcg ccgcggaacc gcactacttc gtgcagagcg gcctgttcaa
    12301 cggccgcgcc gggatcctgg cctacctgct gcacaccggt gcggggcccg gcgacccggc
    12361 ggtgcggcgc catctgcgca acatcggctg gcacgccgtc ccgttccccg gccgggagtc
    12421 cgaccaggag cccgagcggg acgccgagcg ggacgccggc ggggcgccgg agcggatcgc
    12481 cttcatcggg gaccagctcc tgcggctgtc gatggacctg gccaccggat cggccggggt
    12541 cctgctcacc ctgggcgccg cgctgagcgg ccgccccctc gaactcccct tcctcagtcc
    12601 cgcggaaggg gcggaccgat gacgatcctc gacaccgcga aggaggtgaa caccgacatg
    12661 gcctcgatcc tcgaactgca gaacctggac gtcgagcgcg ccgactccgc agccgccgcc
    12721 gacagcaacg gcagcgtgtg ggaatgctgc agcaccggca gctgggttcc cttcacctgc
    12781 ggctgctgat cgacgttccg taccccgccg atcgcgaccg cacgctcccg acccccttac
    12841 gtgaccggaa agaggtgaaa ccgaaaatgg cgaagattct cgaactccag agcctccacg
    12901 tcgagcacgc cagcggagcg cgaagcgact tcagctggtg ggagtgctgc agccagggca
    12961 gcctgttcaa ctgctgctga ccggccgagc cgaccgatgg cggtccgtcc ggggcggggt
    13021 gcgccgcgcc ccgccccggg cgggcccgaa cacgacgaga gccgggggtg cggaagtgcg
    13081 tcgggtgcgt ggccgcggcc ggatggcgcc gctggtggcg gccgccctgg ccggcgtcgg
    13141 ctgcaccgtg gcgctgccgg cggtcctggg cgcggccacc gaggccgtcc tggccggcgg
    13201 ggacgcgcgg gtgccgctgt cggtgctggt cgcgctgctg gccgcggcgg tggcggcggc
    13261 ctacgcgctc aaggtggcgg aggtggcgtg catgtccgcc gagaccgtcc ggctccgatc
    13321 gcggctgatc gagcacgtgc tggcgctggg ggtgcccggc gagcgcgcgt tcgccccggg
    13381 cgacctggcg agccgggtgg tcaccggggc gtcccgggcg gcgggcgccg caccggtgct
    13441 cgtccagctc gtcgccgggc tggcgacctc gctcggcggc gtcgccgcgc tgtggctcat
    13501 cgactggcgg ctggtggcga ccgtcgccct cgcggtcccg gccgggctgg cgatgatgcg
    13561 gatcttcgtg cgccacgcgt ccggcctggt ggcgcgctat caggagctgc agggcgagat
    13621 ctccacccgc atgctcgacg ccctggcggg gatccgcacc gtccggggcg cgggcacctg
    13681 gcggcgggag gccgaccgga tcctcgcgcc ccttcccgaa ctggccgtct cgggacggga
    13741 cctctggcgc gcctacggcc ggatccaggg gcaggggacg ctgctggtcc cgctgacggg
    13801 gctggccgcg ctggccgtgg ccgggcaggg cgtgctggcg ggccggatct cgccggggca
    13861 gatgctcgcg gtcgccggct acgcgccgat ggcgctcggg ctcctcgggc aggtatcgat
    13921 gctgctgggg ctggcgcggc tgcgcgcggg cgagcagcgg atcgacgaag tgctgtcggt
    13981 gcccgtaccg gagcgcgggc gccgcccgct gccggacggc ccgggcgagc tgcgcctgcg
    14041 cggggtgacc gtgcacggta ccgacgggcc gctgctggag gccgtcgacc tggccgtccc
    14101 ggccggacgg tccgtcgcga tcgtgggacg gtcgggggcc gggaagacca cgctcgccat
    14161 ggtcgcgggc gggctcctcg aaccggacgc ggggcgggtg ctgctggacg gcgtccccct
    14221 ggccgaggcc gaccccgcct cgctgcggcg cgcggtggcg tacgccttcg agcggccgcg
    14281 gctgcggggc gcttcggtcg ccgacgcgat cggctacggg tgcgggacgc cgccccgcga
    14341 gcggatcgag ggggccgcgg cgctggcggg cgcggaccgg ttcgtccggc tgcttcccgg
    14401 gggatacgac accccgctgc gcgaggctcc gatgtcgggc ggcgaggagc agcggctcgg
    14461 cctggcgcgg gcgttcgtcc ggcccgcccg gctgctcgtc ctggacgacg ccacctccag
    14521 cctcgactcg gtgaccgagg cgcaggtggc ggccgcgctc gcgcgggccg cggcggggcg
    14581 cacccggctg gtcgtcgcgc accgggcggg cacggccgcg cgcgccgacc tggtggcgtg
    14641 gctggacggc ggcgcggtgc gggccgtcgg gccgcaccgc gagctgtggc gggagcgcgc
    14701 ctaccgggag ctgttcgagc ctccggcacc cgcgtcccgt cccggcggta ccggatcggc
    14761 ccgggacgag ggggcaccat gaccgcaccg aacacaccgg acacaccgga cgttccggcg
    14821 gacgcggtgc ccgggctcgg acgccgggcg tggcggcggc cgctcgcgga actggtgcgc
    14881 gagcgccgcg ggctggccgt gacgctggcg tggtcgctcg ccgcgaccct gcccgcgctc
    14941 ctgtcggggc aactggtggc gcggtccctg gaccacggct tcctgcggga cgacctcgcg
    15001 gcgggcctcg gctggctggc ggtgctcggc gcggccatgg tggtggccgc cgcgagcgcg
    15061 cgccgcgtcc cgcccgcgct gggacgggtc gtcgagccgc tccgggaccg gctggtgcgc
    15121 cgggtcgtca cggggacgct gcggcgcgcg gtcggggcgg gcccggggcg ccccgggatg
    15181 tcggtgatca cccgcatgtc ggaacacacc gagaccgtcc gcgacacgac ggcgggcctg
    15241 ctgctgggca tgcagcaggt cgggctcacg gtgacggcgg ccgcggtcgg cctcgccctg
    15301 ctggcgcccg tcgtcgccct gctggtcgtc ccgccggtcg tgctgacgct gctgctgctc
    15361 gtccggctgc tgccggagct ggcggcccgc gagcgcacgt cgctgctggc cgaggagcgg
    15421 gtggccgaca cggtgagcgg cgtcgtgtcg ggggtgcgcg acgtggtcgc gtgcggcgcc
    15481 gcggcggagg cggcgggcga ggccgccggc gtcttccgcg cccaggccgc cgcggagcgg
    15541 gcggccgccc gggcgagcgc gctgcggacc gcgctgggga ccgccggcgg gcacctctcc
    15601 ctcgtcatgg tgctggccgc cgggccgtgg ctgctgcacg gcggcgggct caccaccgga
    15661 gagctgctgg gggcgctcac ctacgtcacc gcgaacctgc agcccgcgct gcgggcggcg
    15721 gtgcagacgg ccggcggggc cgcggtccgc ctcggggtca cgctgcaccg gctggagtcg
    15781 tgcgccggcc ccgaaccgga atcgcggccg gacgccgcac cggcgtccgg caccggagtc
    15841 ccggacggct gcgagctgcg cgtggaccgg ctcaccttcg cctacggcac cggggcggag
    15901 ccggtgctgc gcgacgtgac gttcgcggtg ccgtacggat cgcatctggc cgtcgtcggc
    15961 cccagcggga tcggcaagtc gacgctggcg gacctgctga ccggcgtcgc cgagcccgcg
    16021 cggggcacgg tgtcgatcgg cgggctcccg ctgggggccg tggacccggg ctggttgcgg
    16081 cgcaccatcg cgatcatccc gcaggaggcc tacgtcttcg ccgggtcgct ccgggagaac
    16141 ctcgcctacc tgcgtccggc cgccaccgag gccgagatcg aggacgccgt cacggccctc
    16201 ggcctgggcc cgctgcggga ccggctcggc ggtgccgagg cggccatcgg gtcgagctcg
    16261 gggctgaccc ccggggaacg gcagatgatc gccctcgccc gggtctggct gtcccccgcg
    16321 cggatcgtgc tgctcgacga ggcgacctgc cacctcgacc cggtcacgga ggcgcggatg
    16381 gaggaggcgt tccgggcccg gcccggcacg ctcgtcgtca tcgcgcaccg gctgagctcg
    16441 gcccggcgcg ccgaccgcgt cctcgtcatg gacggagagc gcacggttct cggccggcac
    16501 gacgaactgc cgcggcgctc cggcctctac gccgacctcg tcggcgcctg gcaggccgga
    16561 cgtcaggagg acgagcggcg ggacggcgcc cgcgtcgacc agcctcactg acctttccga
    16621 aaacatgcct ttccagaact gagagctgcg ttctacattg tggggaccgc caagggaggg
    16681 agtgacgtga gcgcccccgt ttactgggac ccgtacgacc cgcggttctg gcaggacccg
    16741 tacccgacct acggccgtct ccgggaggag gcgccgctgt actacaacga gaagcacgac
    16801 ttctacgccg tgacccggtt cgccgacgtc gagcggggcc tgcccgactg gcggacgttc
    16861 tcctcggccc gcggcggcat cctggagctg atcaagtcgg ggatcgagat cccgccgggc
    16921 accctcatct tcgaggaccc cgacatccac gacgtccacc ggcggctgct cgcccgcgtc
    16981 ttcaccccgc gccggatcgc cgaactggag ccgcgggtcc gcgacttctg cgtccggacg
    17041 ctggacccgc tggtgggcgc gacggagttc gacctgatcc gcgaggtcgg cgtccagatg
    17101 ccgatgcgcg tgatcggcat gctgctgggc atccccgagg ccgaccagga ggccatccgc
    17161 gactccgccg acgaggccct gcgcaccgag cccggcgggc agatggacca cgcggacggc
    17221 tcgcacttca gcaacgagat gttccgcgag tacatcgagt ggcgcgcgaa gaacccgtcg
    17281 gacgacctca tgaccgtcct gctgaacacc gagttcgagg acgaggacgg caccacccgc
    17341 accctcaccc acgacgaggc cctgacctac accaccgtcg tggccggcgc cgggaacgag
    17401 accaccggac ggctcatcgg ctggctcggc tccgtgctcg cccagcaccc cgaccagcgg
    17461 cgggccctcg tggacgaccc gtcgctgatc cccggcgcga tcgaggagac gctgcggtac
    17521 gagccgcccg gtccgtccat cgcccgctac gtcaccaggg acgtcgagtt ccacgggcgc
    17581 accgttcccg agggcagcgc gatgctgttc atcgtggccg cggccaaccg ggacgagaac
    17641 cggtaccccg atcccgaccg gttcgacgtc cgccgcggga tgagccagca gctgaccttc
    17701 ggcctcggcg tccactactg cctcggcgcc gcgctcgccc ggctcgaggg gcgggtggcg
    17761 ctggaggaga tgctcaagcg cttcccggag tgggacgtcg actgggacgg cgccaagctc
    17821 gcccagacga cgaccgtccg cggctgggag acgctcccgc tcacgatcgg ctgacccccg
    17881 acccccgtcg ctgcagaagc acattctccc catcgcggaa ggccggtgtg agcgtgcacg
    17941 gtacggaaac gagccaggcc cggcggatcg cgctgctggc gaaggagcgc ccggactggc
    18001 ccgcctacct gcacgtgcgg gcggacggca ccgaggaggc ggtcacctgc gcccggctgg
    18061 acgaccgggc gggcaggctc gccggcgcgt tcgccgagcg cggtgtcggg cacggcgacc
    18121 tcgtcggcct gggcctgcgc aactccccgc ggttcgcgat gagcgtgttc gccgcgtgga
    18181 agctgggcgc ggtgccggtg ccggtgcgct gggacgtccc ggactgggag ctcgaacgac
    18241 tgaaacgcgt gatcgatcct cgcctctacc tcggcccgga cgacctggac tggatcgacg
    18301 cgtcggccgc gcgcccggta ccggagctgc ccgacgtggt gtccccgcac atgcagggca
    18361 tctgcagcag cggctccacc ggcaccccga agatcatcct gagtgcggcg cccgccgtgc
    18421 acaacccggt gctcagcacg ccgatggccg aggcctggat gccggttccc cggccgcaga
    18481 ccgtcctggt cctggcgccg atgtaccacg tgaacgcgtt cgcgacgctg tacagcctgg
    18541 tcgacggcga ccggctcgtg gtgatggaga agttcgacgc cgcgctggcc ctcgagctga
    18601 tcgaacggca ccgcgtcacg acgttcacgg cgacgcccac gatgctgcag cggatggcgg
    18661 acgctcccgg agccgatgac cgcgacctgt ccagcctcgt gtggctccag cagggcgcgg
    18721 cgccgatgcc cccgtcgctg gtgcaccggt gggcggagct gatcggcccg gagcgcatcg
    18781 tgatggcgta cgggatgacc gaggcgctcg gcatcaccgc gctgcggggc gacgagtgga
    18841 tgctgcacca gggcagcgtg gggcgcgggc tgcgcggcac cgaggtccgg atcctcgacg
    18901 ccgacggccg cgacctgccg ccgggggaac tcggcgagat cttcctgcgc gccccgtcct
    18961 acggcggttc gacctacctc ggccaggccc cgcggctcgc ggagaccccg gacgggttcc
    19021 gcgccgtggg cgacatgggc tacctggacg gcgacggcta cctctacctc gtcgaccgcc
    19081 gggtcgacat gatcacatcc gggggcgcga acgtcttccc cgcggaggtc gaggcggcac
    19141 tgatcgacca cccggagatc gccgacgtcg tggtcatcgg gctgcgcgac gccgagtggg
    19201 gccgccgggt gcacgcgctc gtccagccgg ccgatccggc ggcgccgccc accgcggccg
    19261 aggtcgtcgc ctacgcgaag ggacgcctgg cgccctacaa ggtcccgaag acggtcgagc
    19321 tggtcgacgc gatcccgcgc agcgcggcga cgaaggtgaa ccgcggacgg ctcgtcgagg
    19381 cgcggggcgg ttgacgcccg ccacggcgga cctatggccg acggacgtgg cgggaggcct
    19441 gcgtgggcag gtcggcgtag gtgacgatgc cgggcctggc ggcgaccacc gcggggacgg
    19501 cgttgacgac cggcatcgcc gtgatcaccg agccgatggc gagcatgtcc tccaggctca
    19561 tcgaggccat gtcctgcggg aggacctcga cccgcaggtt gacctgcggg tggccgcgga
    19621 cctcgatgag gtaggccatc gccacctccc aggccgggtc gagctcggac gtcaccgtcc
    19681 accggatgtg ggcctcgacg gcgtcggcgc cgcccgacac gccgatccac cggacgtcca
    19741 gcccggcgac cgtgccgcgc ccgaccgggc gtccgggaag gtccagatcc ttggtggcgt
    19801 gggcgaagcc gacctcgcag cggacgtcgt cgatggacgt gccgagcagt tcggcgagcg
    19861 cctccacggc gtcgccgaac ggcgccgtgg cccggacgac gtcgtcggcg tggcccggat
    19921 cgcccgcggg ccggccccag cccagctcgt cctggttcgc gtccccggcc cacatgccga
    19981 tgtcgaacga ctcgaacacc gtgacgtact cgacctcgcg gcagacgccg gaggcgaccg
    20041 cggcgagctg gtcggcgtag ccggggttga cgccgctgcc gaacaggctg gccccgcccg
    20101 cccgcgccgc atcgtccagc gccgcccgcg cctcctcgcc gtaggcgcga ccggtcagga
    20161 acgacgcggt cgacaggacg ttgacgcccg cgcgcagcag ccgcgtcagg tgctccacgt
    20221 cggggtgcag cggcatgtac aggacgcagt cgggcgcgag cgcgatgatc tcgtcgatgt
    20281 cgttcgtggc ggtgacgccg accgtgcgcc cgagaccggc gagctcgccg gcgtcccgac
    20341 ccaccttgtc cccgctgaag gcgtacagcc cgacgagttc gagctcgggc cgctcgacga
    20401 cggctcggag cgactgcctc gcgacgttgc ccgtcgtcca ctggacgacg cggacggggc
    20461 gatcggagat gggttccacc gggcctcctc gacttcaccg gagcccgagc ctaggcaggc
    20521 gacttgacca gagtcaacat tttcggcccc gtctcgcgcc gcgatcgaac gagaatctcg
    20581 gccgggggac gcccaggaaa gctgaccgcg ctcagctttc ctgggcgtcc ccggacgcga
    20641 tccgcgcgtg gcccgcgacg aacgcggcga tgtcccggcc cacgacctcg gcgaagccgc
    20701 ggtccccgta ctccccggcg gcccagtgcc gggtgcccgc ctccaggagc gcctggacgc
    20761 cccgcgccac gtggagcacg tccagtccgg gcgggagccc gccgtcgcgc tgggcgcgcc
    20821 gcaacagttc gaggaagagg tacctgctcg cgtggtgctc gtccgggcgc ccctcgcgca
    20881 gggcccggtg ctcggcgcgg tggccttcca gggtggcctc gatgagcagg tccggtgggc
    20941 tgtgccgcat gctccgctcc agcgcggcga gcaccgcgcc gatcgcctcc ggcagctcgc
    21001 cgggaccggc gcgccgcgcg cgggccacgc ggcgcgcgtc cccggtggag agcacgcccg
    21061 cctcggcgag ggcgtcctcc ttggtcggga agtagaagta gaacagggcc ttggacaccc
    21121 cggcggcctt gcagatgtcg gcgaccgtcg taccggcgaa cccgttcgtc cgccacagcg
    21181 cgatcgcggc ctgcagcagg gcgcgcctct tctccaccga acgcgactgc gcgagactgg
    21241 cccggcgctg accccggtca gcactcactc gggatcggcc cttcggttcc gcttcctcca
    21301 tgaccgccac cctaccggcc acgatgctga ccacagtcag ctacataccc cggacgcccg
    21361 tgcgcgcggc gtcggacgcg ccgggcgcgc cgtcccgttc aggggcgccg tcccgttcgg
    21421 ccgcgcgggc gatgccggcg cacatgccgc cgaagacgcg atcgtggaag ggccggaacg
    21481 cccaccagta cgcgtggccc gccagccccc gcgggtggaa cagcgcccgc tgggtgtagc
    21541 gggtgcggcc gtcccgctcc accaccccga gttccagcca cgcaaggccg ggcagccgca
    21601 tctcggcgcg gagccgcagc agccgccggg gctcgatctc ctccacccgc cagaagtcga
    21661 cggtctcgcc gatccgcagc cgccgcgggt cgcggcggcc gcgccgcagg cccaccccgc
    21721 ccaccaggcg gtccaggacg ccgcgggcgc gccacgcgag cgggaaggag taccagccgc
    21781 ggtcgccgcc gatcccctcg atgaccgtcc acaggcggtc ggcggacgcg gccacctcgc
    21841 cgccccgctc gtcggtgtac aggctgcccc cggaccagtc ggggtcggtc ggcagcgggt
    21901 cgctgggggc gccgggcatg ctcgccgacg accagcgggt ggccacgtcg gcgtcgcgga
    21961 cgcggcgcag cgccagctcc accccgcgct cgaagcccgc cgcgccgccg ggcggcgggg
    22021 acacgtaccg gtcgatgtcg tgctcgcggc acaccacctc gttgcgcagc gactccacca
    22081 gcggacgggc caggctcccc ggcaccggcg tgatcgcgcc gacccacagg ctcgacagcc
    22141 acgggctcag caccgggacc gggacgatga gccgccgccg cagccccgcg acggccgcgt
    22201 agcggcgcat catgtccacg taggtgagca cgtccgggcc gccgatgtcg aagccccggc
    22261 tgacatgggc gggcaggtcg gcggccccga ccaggtagtg caggacgtcc cggatcgcga
    22321 tcggctggat ccgcgagtgc acccagcgcg gggtgaccat caccggcagc cgctcggtca
    22381 ggtaccgcag catctcgaac gacgccgacc ccgagccgat gatcacggcg gcgcgcagcc
    22441 agacggcggg caccccggcg tccagcatga tccggccgac ctccgcgcgg gaccgcagat
    22501 gcggcgacgg ctcctcttcc gggtccatcc cgcccaggta gaccagccgc cgcacgccgg
    22561 cgtcgcgggc cgccgcggtg aaggtgcgcg cggcgcggcg gtcgcgctcg gcgaagccgt
    22621 cg
//
