LOCUS       NZ_CP044407            22776 bp    DNA     circular CON 28-JUL-2024
DEFINITION  Actinomadura sp. WMMB 499 strain WMMB499 chromosome, complete
            genome.
ACCESSION   NZ_CP044407
VERSION     NZ_CP044407.1
KEYWORDS    RefSeq.
SOURCE      Actinomadura sp. WMMB 499
  ORGANISM  Actinomadura sp. WMMB 499
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Thermomonosporaceae; Actinomadura.
REFERENCE   1  (bases 1 to 9187113)
  AUTHORS   Braun,D., Bugni,T.S., Chevrette,M.G. and Currie,C.R.
  TITLE     Draft genome of Actinomadura sp. WMMB499
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9187113)
  AUTHORS   Braun,D., Bugni,T.S., Chevrette,M.G. and Currie,C.R.
  TITLE     Direct Submission
  JOURNAL   Submitted (26-SEP-2019) Pharmacy, University of Wisconsin-Madison,
            777 Highland Ave., Madison, WI 53705, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Canu v. Oct-2016
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 300.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_008824145.1-RS_2024_07_28
            Annotation Date                   :: 07/28/2024 05:00:58
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,523
            CDSs (total)                      :: 8,413
            Genes (coding)                    :: 8,251
            CDSs (with protein)               :: 8,251
            Genes (RNA)                       :: 110
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 92
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 162
            CDSs (without protein)            :: 162
            Pseudo Genes (ambiguous residues) :: 0 of 162
            Pseudo Genes (frameshifted)       :: 64 of 162
            Pseudo Genes (incomplete)         :: 108 of 162
            Pseudo Genes (internal stop)      :: 10 of 162
            Pseudo Genes (multiple problems)  :: 19 of 162
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 04:12:41
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 427548
            Orig. end                         :: 450324
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP044407.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Genome not circularized.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22776
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="redox-cofactor"
                     /region_number="2"
                     /rules="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /tool="antismash"
     cand_cluster    1..22776
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(PF04055 and (TIGR04085 or SPASM))
                     and (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /kind="single"
                     /product="redox-cofactor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22776
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12776](+)"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12776
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
     misc_feature    296..314
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 18.38"
                     /tool="antismash"
     misc_feature    complement(300..318)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 22.84"
                     /tool="antismash"
     misc_feature    303..321
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 17.02"
                     /tool="antismash"
     misc_feature    307..320
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.37"
                     /tool="antismash"
     misc_feature    complement(314..334)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 19.52"
                     /tool="antismash"
     misc_feature    316..329
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 12.16"
                     /tool="antismash"
     gene            329..1072
                     /locus_tag="F7P10_RS02015"
                     /old_locus_tag="F7P10_02015"
     CDS             329..1072
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070403 - NAD+ binding [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (5-164). E-value: 1.5e-17. Score:
                     56.1. Matches aSDomain:
                     nrpspksdomains_F7P10_RS02015_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012887925.1"
                     /locus_tag="F7P10_RS02015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_02015"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_151007804.1"
                     /sec_met_domain="adh_short (E-value: 3.3e-34, bitscore:
                     117.4, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLQTAVVVTGGASGIGAACARALAEHGRPVALWDRADAADVARDI
                     RADTGTAAFSAVVDVTDTAAFPAALDASREALGPLGGLVHAAGIAGPAAVGDLDEERWD
                     AVQHVNLRAQALLAQAMLDDLRAQEGSAIVGISSIEAFVGQLFIPAYCASKAGLLGLTR
                     SLAHLLAGDGVRVNAVCPGYIDTPLLTGAAPPEMRAEFAAKAPVGRLGRPAEVAAAVRF
                     LLSEEASFITGTHLTVDGGSTAVDR"
     CDS_motif       344..412
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_F7P10_RS02015_0001"
                     /evalue="3.00E-07"
                     /label="PKSI-KR_m1"
                     /locus_tag="F7P10_RS02015"
                     /protein_end="28"
                     /protein_start="5"
                     /score="23.1"
                     /tool="antismash"
                     /translation="VVVTGGASGIGAACARALAEHGR"
     aSDomain        344..820
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_F7P10_RS02015_PKS_KR.1"
                     /evalue="1.50E-17"
                     /label="F7P10_RS02015_PKS_KR.1"
                     /locus_tag="F7P10_RS02015"
                     /protein_end="164"
                     /protein_start="5"
                     /score="56.1"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="VVVTGGASGIGAACARALAEHGRPVALWDRADAADVARDIRADTG
                     TAAFSAVVDVTDTAAFPAALDASREALGPLGGLVHAAGIAGPAAVGDLDEERWDAVQHV
                     NLRAQALLAQAMLDDLRAQEGSAIVGISSIEAFVGQLFIPAYCASKAGLLGLTRS"
     gene            1122..1955
                     /locus_tag="F7P10_RS02020"
                     /old_locus_tag="F7P10_02020"
     CDS             1122..1955
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (8-169). E-value: 1.5e-13. Score:
                     43.0. Matches aSDomain:
                     nrpspksdomains_F7P10_RS02020_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF004528.0"
                     /locus_tag="F7P10_RS02020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_02020"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_151007805.1"
                     /sec_met_domain="adh_short_C2 (E-value: 7e-38, bitscore:
                     129.9, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGPLDGTAALVTGGGSGIGLGCAVRLAAAGAAVTICGRTESRLRD
                     AVERAGKDGFEIAHVVADVTDDAQVENAVRAAGERGPLRTVVASAGGSSSVGPIGDLDL
                     EQWRATLELNATGTMLTIRHASRAMARGGGGSIVAISSIAASNTHRWFGAYGVSKAAVD
                     HLVRLAADELGGAGIRVNGVRPGIVRTELVAGIADTGPVLDDYLSCMPLSRVGEPEDIA
                     GAVAFLAGPESSWITGQVLNVDGGHHLRRGPDYSSFFEPMFGADALRGVPPEDPR"
     aSDomain        1146..1628
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_F7P10_RS02020_PKS_KR.1"
                     /evalue="1.50E-13"
                     /label="F7P10_RS02020_PKS_KR.1"
                     /locus_tag="F7P10_RS02020"
                     /protein_end="169"
                     /protein_start="8"
                     /score="43.0"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="ALVTGGGSGIGLGCAVRLAAAGAAVTICGRTESRLRDAVERAGKD
                     GFEIAHVVADVTDDAQVENAVRAAGERGPLRTVVASAGGSSSVGPIGDLDLEQWRATLE
                     LNATGTMLTIRHASRAMARGGGGSIVAISSIAASNTHRWFGAYGVSKAAVDHLVRLA"
     CDS_motif       1149..1235
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_F7P10_RS02020_0001"
                     /evalue="1.00E-02"
                     /label="PKSI-KR_m1"
                     /locus_tag="F7P10_RS02020"
                     /protein_end="38"
                     /protein_start="9"
                     /score="8.5"
                     /tool="antismash"
                     /translation="LVTGGGSGIGLGCAVRLAAAGAAVTICGR"
     CDS_motif       1491..1544
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_F7P10_RS02020_0002"
                     /evalue="2.20E+00"
                     /label="PKSI-KR_m1"
                     /locus_tag="F7P10_RS02020"
                     /protein_end="141"
                     /protein_start="123"
                     /score="1.1"
                     /tool="antismash"
                     /translation="HASRAMARGGGGSIVAIS"
     gene            2012..3163
                     /locus_tag="F7P10_RS02025"
                     /old_locus_tag="F7P10_02025"
     CDS             2012..3163
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1103: FAD dependent oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013434.4"
                     /locus_tag="F7P10_RS02025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_02025"
                     /product="FAD-binding oxidoreductase"
                     /protein_id="WP_151007806.1"
                     /sec_met_domain="DAO (E-value: 2.5e-41, bitscore: 141.4,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRIVIVGGGIIGAALADRLARTAEVTLVERDRPGAGTSAASYAWL
                     NANDPADPGYHAFRVAALDAWRRTAAGFGDPGWCRFAGNTAWAVDEPDRDALADRVARL
                     RDLGYPATLITATRLRDAEPSLRPPPGAVIARYPGEGHAHGSAAVAALLGRARDAGARI
                     LAGAAATRLNVRGERVTGVRTSTGDDLDADVTICAAGWRSPALLATAGVGLPLVDPAAP
                     GSSAPGLTATTTRVPGLVNGLVHSPGLDLRPTPEGGLVLEAADLDADTDLASSQADLDA
                     RAAELLDRARALFPGCTARLGEVRRCVRPLPVDGRPLVGPQRPGLYTVVTHSGITLGPY
                     LAGLVAGEVAGEGADPALAPYRPDRPLPEPSSGPSSGPPSGPS"
     misc_feature    complement(2055..2069)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.8"
                     /tool="antismash"
     gene            complement(3091..3645)
                     /locus_tag="F7P10_RS02030"
                     /old_locus_tag="F7P10_02030"
     CDS             complement(3091..3645)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="F7P10_RS02030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="F7P10_02030"
                     /product="hypothetical protein"
                     /protein_id="WP_218040330.1"
                     /transl_table=11
                     /translation="MRAVPDRLRGLYGAGPPHVLALAVCFALAGYAALRIFSTTPWPFV
                     LAWFAGCVVAHDLVLFPLYAVADRALTGALRAGRARTRAGPPRVSPLNHLRVPFAASGL
                     LLLLFFPMIAQWRERDYTAASGRTEDPYLGRWLLVTAALFAGSAVLYALRLRRAGRDQD
                     GPDGGPDDGPDDGSGSGRSGR"
     gene            complement(3647..4915)
                     /locus_tag="F7P10_RS02035"
                     /old_locus_tag="F7P10_02035"
     CDS             complement(3647..4915)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017567801.1"
                     /locus_tag="F7P10_RS02035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_02035"
                     /product="molybdopterin-dependent oxidoreductase"
                     /protein_id="WP_254716359.1"
                     /transl_table=11
                     /translation="MRLWRALERRRPPGLGRSRAWRSPLRGPWLTSVFGAVLLVALPVV
                     IVTGLLSYAAYAPRFGQAFPPDVGWLRLPYFDWPTRPVWLYQVTQGVHVLLGLALVPVV
                     LGKLWSVVPKLFAWPPGRSIAQVLERLTLLLLVGGILFQIVTGVLNIQYTYVFGFSFYE
                     GHYYGAWVFIGAFVAHVILKLPRMVRALRSRPFRDALRDGRPEPPDPDGLVPAAPRPAT
                     MTRRGVLALAGGGGLLIAVLTVGQAVGGTAARRLAPLAPRGGYAPGPGDFPVNRTAAAA
                     GITAADAGERWRLVLTGARTVELDRAALLALPQHTAELPIACVEGWSTVQTWTGVRLRD
                     LAAAAGVPEPASAHVRSLERFGAFNQATLQANQVADPDSLLALRVGGADLTLDHGHPAR
                     VIVPALPGVHNTKWVRLIEFRER"
     misc_feature    complement(4994..5008)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.64"
                     /tool="antismash"
     gene            5260..5712
                     /locus_tag="F7P10_RS02040"
                     /old_locus_tag="F7P10_02040"
     CDS             5260..5712
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017609542.1"
                     /locus_tag="F7P10_RS02040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_02040"
                     /product="CrcB family protein"
                     /protein_id="WP_218040331.1"
                     /transl_table=11
                     /translation="MTPSPRTPRPGPSFLRREAAVVAAVSLGGGLGAAARHGASLAWPA
                     HGSAFPWTTLAVNALGCALIGVLMTVLARVRATHPLVRPFLGTGVLGGFTTFSAFAADG
                     HGLLADGHARLGLAYLAATPVVAVAAAWGAAALTRRLAARTVREAR"
     gene            5709..6083
                     /gene="crcB"
                     /locus_tag="F7P10_RS02045"
                     /old_locus_tag="F7P10_02045"
     CDS             5709..6083
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:1903425 - fluoride transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:1903424 - fluoride transmembrane transport
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="crcB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017539693.1"
                     /locus_tag="F7P10_RS02045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_02045"
                     /product="fluoride efflux transporter CrcB"
                     /protein_id="WP_151007809.1"
                     /transl_table=11
                     /translation="MSWLLVVAGGMAGAPLRYLADRAVRARNGSAFPWGTFAANVLGCL
                     VLGVLTGAVVHGAASHPVQMLAGTGLCGALSTYSTFSFETVRLAESGARLLAAANVVVS
                     VVAGLAAVVAGIAAAEAVWA"
     misc_feature    6104..6113
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.29"
                     /tool="antismash"
     gene            6142..7563
                     /locus_tag="F7P10_RS02050"
                     /old_locus_tag="F7P10_02050"
     CDS             6142..7563
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017: aldehyde dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012398.4"
                     /locus_tag="F7P10_RS02050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_02050"
                     /product="aldehyde dehydrogenase"
                     /protein_id="WP_151007810.1"
                     /sec_met_domain="Aldedh (E-value: 1.7e-149, bitscore:
                     497.2, seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPVRHDHWIGGRNERPAGSAYLPTVDPATREPGDEIAAGSAPDAE
                     RAVASAAGAQPDWARMSGAERSGTLHRIGDAIEADAGALMELERACTGKTPAQLRMEAE
                     MSAAYFRYYAGVLRAHGGRTIDQGARHHTYTRFEPFGVIAAITPWNLPLNQACRALAPA
                     LAAGNAVVAKPSEFTSASTLHLARLATAAGLPDGLLNVVTGTGPGAGAPLAAHPGVRRI
                     TFTGSVATGRRLAGVAADRLIPVTLELGGKSPLVVFADADLDRAVAAAVAAVATNAGQV
                     CSATARLLIEASVHDEVVARIVTAVEKLEPGTDFGPIITEDQFGKVLGHVDAARAAGLA
                     PVTGGAAYTEGPAARGRYIRPTVYAAVPPDAAVAREELFGPVLVTMPFTGEDEALAMAN
                     DTDYGLVAAVWSGDVARGLRLAERIDAGQVSVNGGPLTIETPFGGFKDSGHGREKGIEA
                     LHEYGQTKAISLSLD"
     gene            7661..8236
                     /gene="mftR"
                     /locus_tag="F7P10_RS02055"
                     /old_locus_tag="F7P10_02055"
     CDS             7661..8236
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0036042 - long-chain fatty acyl-CoA
                     binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene="mftR"
                     /gene_functions="regulatory (smcogs) SMCOG1215: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017593160.1"
                     /locus_tag="F7P10_RS02055"
                     /note="MftR, the mycofactocin system transcriptional
                     regulator, is an uncharacterized TetR family DNA-binding
                     transcription factor. Its role is inferred by context. It
                     occurs as part of the biosynthesis locus for mycofactocin,
                     a partially characterized electron carrier derived from the
                     terminal Val-Tyr dipeptide of the precursor peptide MftA,
                     through a radical SAM enzyme-mediated process.; MftR, the
                     mycofactocin system transcriptional regulator, is an
                     uncharacterized TetR family DNA-binding transcription
                     factor. Its role is inferred by context. It occurs as part
                     of the biosynthesis locus for mycofactocin, a partially
                     characterized electron carrier derived from the terminal
                     Val-Tyr dipeptide of the precursor peptide MftA, through a
                     radical SAM enzyme-mediated process; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="F7P10_02055"
                     /product="mycofactocin system transcriptional regulator"
                     /protein_id="WP_254716360.1"
                     /transl_table=11
                     /translation="MTSRPALERLAFELFARQGFDETTVDDIAAAAGIGRRTFFRYFAS
                     KNDLVWGDFDEQLRRLRTLLDEADPSTPIMDAVRRAVVEFNRFDPQEVPWHRQRMELIL
                     TVPTLQADATLRYASWRRIVAEFVAARTGRPASALAPRLAGSVILAAAVAAYEHWLAAA
                     DGTPLADLLDDTLRRVEAGFAELGGPGR"
     gene            complement(8243..9754)
                     /gene="mftG"
                     /locus_tag="F7P10_RS02060"
                     /old_locus_tag="F7P10_02060"
     CDS             complement(8243..9754)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016614 - oxidoreductase activity, acting
                     on CH-OH group of donors [Evidence IEA]"
                     /codon_start=1
                     /gene="mftG"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012852714.1"
                     /locus_tag="F7P10_RS02060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_02060"
                     /product="mycofactocin system GMC family oxidoreductase
                     MftG"
                     /protein_id="WP_151007812.1"
                     /transl_table=11
                     /translation="MLIGRRPDVLVVGAGGTGAVLAARLSEDPGRRVLALEAGPVPAAF
                     PADLLDARLVPGARPGHPAVRTFPARLTPGMPYEAARGRVLGGSTTVNGGYFVRARRAD
                     FDRWSAEEAGGAAWTYERMLPFMRALENDLDHGATALHGGRGPVPVRRVGLDHPAAAAF
                     GAAARELGYPDDPDKNAQEPPGFGPVPSNAVDGRRVNTGLAYLLGAAAGRPNLTVAGEC
                     PVRSVVVRDGRAAGVVVGDGTVLEAGEIVLCAGALSTPHLLHLSGIGPAADLERAGIPV
                     VLDLPVGTALSDHPQLVVEWAPRRPMDGPSGSWLGGVLHLPSAGGPAAGDLEILQSLVP
                     MAGLVGGRADVPDMPPAFLASVQAPVRSGNLRTVSPDPDVPPRIDYGYLRTGADRRRMR
                     EAVRATVALVTSGAFGEVCAGPVEPVPVDDDRVLDAWIRARLGTSQHTCGTVPMGAAVD
                     ARGRVHGVRGLRVADTSILPTAPLRGPAATAVLIGEAVADAVRRG"
     misc_feature    complement(9782..9795)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.27"
                     /tool="antismash"
     misc_feature    9782..9796
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.0"
                     /tool="antismash"
     misc_feature    complement(9829..9844)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.26"
                     /tool="antismash"
     gene            9884..9997
                     /gene="mftA"
                     /locus_tag="F7P10_RS02065"
                     /old_locus_tag="F7P10_02065"
     CDS             9884..9997
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_process="GO:0140604 - mycofactocin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="mftA"
                     /inference="COORDINATES: protein motif:HMM:TIGR03969.1"
                     /locus_tag="F7P10_RS02065"
                     /note="Mycofactocin is a small molecule electron carrier
                     derived from the final two amino acids, Val-Tyr, of MftA,
                     the mycofactocin precursor. It plays a role in redox
                     homeostasis and the metabolism of alcohols and aldehydes in
                     Actinobacteria, including Mycobacterium tuberculosis;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /old_locus_tag="F7P10_02065"
                     /product="mycofactocin precursor MftA"
                     /protein_id="WP_151007813.1"
                     /transl_table=11
                     /translation="MDSAAPENQNADERAEEIAAAESLIEEVSIDGMCGVY"
     gene            10001..10276
                     /gene="mftB"
                     /locus_tag="F7P10_RS02070"
                     /old_locus_tag="F7P10_02070"
     CDS             10001..10276
                     /GO_process="GO:0140604 - mycofactocin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="mftB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: Mycofactocin_RRE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012852712.1"
                     /locus_tag="F7P10_RS02070"
                     /note="MftB, a small protein, is a peptide chaperone that
                     assists the radical SAM enzyme MftC in performing two
                     modifications to the C-terminal Val-Tyr dipeptide of the
                     mycofactocin precursor peptide, MftA. MftB's role is
                     analogous to the role of PqqD in the biosynthesis of PQQ, a
                     cofactor that derives entirely from a Tyr and a Glu in the
                     precursor PqqA.; MftB, a small protein, is a peptide
                     chaperone that assists the radical SAM enzyme MftC in
                     performing two modifications to the C-terminal Val-Tyr
                     dipeptide of the mycofactocin precursor peptide, MftA.
                     MftB's role is analogous to the role of PqqD in the
                     biosynthesis of PQQ, a cofactor that derives entirely from
                     a Tyr and a Glu in the precursor PqqA; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="F7P10_02070"
                     /product="mycofactocin biosynthesis chaperone MftB"
                     /protein_id="WP_151007814.1"
                     /sec_met_domain="Mycofactocin_RRE (E-value: 2.8e-29,
                     bitscore: 100.1, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPAIDLDRAWDLHPQVSVRPEPFGALLYHFGTRKLSFLKDRRLLE
                     VVRGLRDAATARDACTAADVPASDLPRYGAALGALASSSMLVERTP"
     aSDomain        10019..10258
                     /aSDomain="Mycofactocin_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a mycofactocin
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_F7P10_RS02070_Mycofactocin_RRE.1"
                     /evalue="9.30E-32"
                     /identifier="RREFam016.1"
                     /label="F7P10_RS02070"
                     /locus_tag="F7P10_RS02070"
                     /protein_end="86"
                     /protein_start="6"
                     /score="100.1"
                     /tool="antismash"
                     /translation="DRAWDLHPQVSVRPEPFGALLYHFGTRKLSFLKDRRLLEVVRGLR
                     DAATARDACTAADVPASDLPRYGAALGALASSSML"
     gene            10273..11523
                     /gene="mftC"
                     /locus_tag="F7P10_RS02075"
                     /old_locus_tag="F7P10_02075"
     CDS             10273..11523
                     /EC_number="1.3.98.7"
                     /EC_number="4.1.99.26"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_process="GO:0031179 - peptide modification [Evidence
                     IEA]"
                     /GO_process="GO:0140604 - mycofactocin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="mftC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: SPASM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QueE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012852711.1"
                     /locus_tag="F7P10_RS02075"
                     /note="MftC is a radical SAM/SPASM enzyme that catalyzes
                     the first two steps in biosynthesis of the electron carrier
                     mycofactocin from the terminal Val-Tyr dipeptide of the
                     precursor peptide MftA.; MftC is a radical SAM/SPASM enzyme
                     that catalyzes the first two steps in biosynthesis of the
                     electron carrier mycofactocin from the terminal Val-Tyr
                     dipeptide of the precursor peptide MftA; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /old_locus_tag="F7P10_02075"
                     /product="mycofactocin radical SAM maturase"
                     /protein_id="WP_151007815.1"
                     /sec_met_domain="PTHR43273 (E-value: 1.4e-39, bitscore:
                     135.0, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 1.2e-24, bitscore: 86.5,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="QueE (E-value: 5e-08, bitscore: 31.6,
                     seeds: 32, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 3.5e-14, bitscore:
                     51.9, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 4.5e-05, bitscore: 22.8,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTDTASRATQTGPTRLVDLFEHGLDAPICLTWELTYACNLSCAH
                     CLSSSGRRDPRELSTDEAKAVIDELEAMQVFYVNIGGGEPTVRSDFWELLDYATAHHVG
                     VKFSTNGVRITPEVARMLAANDYVDVQISLDGATPEVNDAVRGAGSYDTALRAMRNLSD
                     AGMKNFKLSVVCTRHNIPQMDDFKAIADEYGAQLRLTRLRPSGRGADVWDELHPTQAQQ
                     RELYDWLLAHGDQVLTGDSFFHLSAYGEALPGLNLCGAGRVVCLIDPVGDVYACPFAIH
                     DEFLAGNVRETGGFARVWRESDLFQGLREPQTGGACASCDFYDTCKGGCMAAKFFTGLP
                     LDGPDPECVQGHGEKLLAGRPEDRSGIPKPSGDHSHRTAPRRRREPVLVQLGRRTDMDR
                     PPVSACEENPLAGLRIT"
     gene            11592..12776
                     /gene="mftD"
                     /locus_tag="F7P10_RS02080"
                     /old_locus_tag="F7P10_02080"
     CDS             11592..12776
                     /EC_number="1.4.3.26"
                     /GO_process="GO:0140604 - mycofactocin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="mftD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR03966"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011293397.1"
                     /locus_tag="F7P10_RS02080"
                     /note="MftD, an enzyme found in the mycofactocin
                     biosynthesis locus, performs an oxidative deamination of
                     3-amino-5-[(p-hydroxyphenyl)methyl]-4,
                     4-dimethyl-2-pyrrolidinone (AHDP). The resulting compound,
                     now called pre-mycofactocin (PMFT), is a biologically
                     active redox cofactor that can oxidize the non-exchangeable
                     NADH of TIGR03971 family SDR-type oxidoreductases.; MftD,
                     an enzyme found in the mycofactocin biosynthesis locus,
                     performs an oxidative deamination of
                     3-amino-5-[(p-hydroxyphenyl)methyl]-4,
                     4-dimethyl-2-pyrrolidinone (AHDP). The resulting compound,
                     now called pre-mycofactocin (PMFT), is a biologically
                     active redox cofactor that can oxidize the non-exchangeable
                     NADH of TIGR03971 family SDR-type oxidoreductases.; MftD,
                     an enzyme found in the mycofactocin biosynthesis locus,
                     performs an oxidative deamination of
                     3-amino-5-[(p-hydroxyphenyl)methyl]-4,
                     4-dimethyl-2-pyrrolidinone (AHDP). The resulting compound,
                     now called pre-mycofactocin (PMFT), is a biologically
                     active redox cofactor that can oxidize the non-exchangeable
                     NADH of TIGR03971 family SDR-type oxidoreductases.; MftD,
                     an enzyme found in the mycofactocin biosynthesis locus,
                     performs an oxidative deamination of
                     3-amino-5-[(p-hydroxyphenyl)methyl]-4,
                     4-dimethyl-2-pyrrolidinone (AHDP). The resulting compound,
                     now called pre-mycofactocin (PMFT), is a biologically
                     active redox cofactor that can oxidize the non-exchangeable
                     NADH of TIGR03971 family SDR-type oxidoreductases; Derived
                     by automated computational analysis using gene prediction
                     method: Protein Homology."
                     /old_locus_tag="F7P10_02080"
                     /product="pre-mycofactocin synthase MftD"
                     /protein_id="WP_151007816.1"
                     /sec_met_domain="TIGR03966 (E-value: 3.5e-207, bitscore:
                     686.5, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFQNPWFETVAEAQRRAKRRLPHMVYGALVAGSERGRTVGDNCKA
                     FGDLGFAPHVAGHHAERDLSTTVMGVETSMPVVISPTGVQAVHPDGEVAVARAAANRGV
                     IMGLSSFASKPVEEVAEANPNVFFQMYWSGDRDAMVRRMDRARRAGAKALIATLDWSFS
                     NGRDWGSPMIPEKVDLKTMAKLAPGVLPHPGWLWRFARTKRLPDLTTPNLQPPDGPAPT
                     FFGAYGEWMQTPPPTWEDVAWLRKEWGGPFMLKGVTRVDDAKRAVDAGVTALSVSNHGG
                     NNLDTTPATIRVLPSVAEAVGDQIEVLLDGGVRRGGDVAKALALGARAVLIGRAYLWGL
                     AANGQAGVENVLDIMRGGLDSAVLGLGHSSVGELSPADLAVPPGFALTLGGGED"
     gene            12778..13488
                     /gene="mftE"
                     /locus_tag="F7P10_RS02085"
                     /old_locus_tag="F7P10_02085"
     CDS             12778..13488
                     /GO_process="GO:0140604 - mycofactocin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="mftE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012852709.1"
                     /locus_tag="F7P10_RS02085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_02085"
                     /product="mycofactocin biosynthesis peptidyl-dipeptidase
                     MftE"
                     /protein_id="WP_151007817.1"
                     /transl_table=11
                     /translation="MRDLAGAAWPEVGAASVLVPVGSTEQHGPHLPLSTDTVIAAAVAE
                     RAAAALDGPVLVAPALAYGASGEHAGFPGTMSIGRDALELVLVETVRSLAPWAGRVVFV
                     NGHGGNAGALDAAAGRMRAEGHDAGWVGCGVPGADAHAGFTETSIMLYLAPELVRASRA
                     VAGDTRPLAELMPELVARGVRAVSPTGVLGDPAGASAGRGRELVDAMAAAAARRIRTGR
                     ADARGRLLGPGAAT"
     gene            13485..14978
                     /gene="mftF"
                     /locus_tag="F7P10_RS02090"
                     /old_locus_tag="F7P10_02090"
     CDS             13485..14978
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /GO_process="GO:0140604 - mycofactocin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="mftF"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR03965.1"
                     /locus_tag="F7P10_RS02090"
                     /note="Members of this protein family, MftF, are
                     glycosyltransferases, members of PF00535 (glycosyl
                     transferase family 2). The encoding gene is found as part
                     of the mycofactocin cassette, in Mycobacterium
                     tuberculosis, many other Actinobacteria, and occasional
                     members of other lineages. Mycofactocin itself, a putative
                     redox carrier, is a heavily modified derivative of the
                     C-terminal Val-Tyr dipeptide of the mycofactocin precursor
                     MftA (TIGR03969).; Members of this protein family, MftF,
                     are glycosyltransferases, members of PF00535 (glycosyl
                     transferase family 2). The encoding gene is found as part
                     of the mycofactocin cassette, in Mycobacterium
                     tuberculosis, many other Actinobacteria, and occasional
                     members of other lineages. Mycofactocin itself, a putative
                     redox carrier, is a heavily modified derivative of the
                     C-terminal Val-Tyr dipeptide of the mycofactocin precursor
                     MftA (TIGR03969); Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_02090"
                     /product="mycofactocin biosynthesis glycosyltransferase
                     MftF"
                     /protein_id="WP_151007818.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 6.3e-23,
                     bitscore: 80.4, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSASSRFPLPPGFPIALDEGTSLWSGGRVATGGAPWKVVRLADAA
                     RPHLAALARAGGGGLAASSPTGRAVARLLLDHGLARPVPSPRPGPHGVTVVIPAYGRPD
                     ELARCLAAVEGMPVIVVDDASPDPGPLRRAAAAAGARLVRHPVNRGPAAARNTGLRLVE
                     TPIAALVDSDCRPDPGWLDVLVPHFDDPRVAAVAPRVRPDPGDPRLLARYETARSALDM
                     GVRPALVRPGGRLGFVPTATLLVRVAAVTDPAFDEELRLGEDVDFVWRLGDRGWNVRYE
                     PAARVAHTARLDPVEWARRRHEYGTSAADLARRHPGRLAPARPSLWNLAVLGLLARGRP
                     GLAAACGAAAAALLARRLARLPADWSLAAAIVGKGVLADAAALGHALRREWWPAGLLVL
                     AAAPRRRTARAAALAMLAPIALEWLRERPDVDPVRYTALRLAEDVAYGSGVTAASVRAR
                     SSAPLRPDVRLPDGLSATRAAGRARAAGKRLRSALRISG"
     gene            complement(14968..15774)
                     /locus_tag="F7P10_RS02095"
                     /old_locus_tag="F7P10_02095"
     CDS             complement(14968..15774)
                     /NRPS_PKS="Domain: PKS_KR (7-181). E-value: 6.3e-12. Score:
                     37.7. Matches aSDomain:
                     nrpspksdomains_F7P10_RS02095_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012852403.1"
                     /locus_tag="F7P10_RS02095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_02095"
                     /product="mycofactocin-coupled SDR family oxidoreductase"
                     /protein_id="WP_151007819.1"
                     /sec_met_domain="adh_short (E-value: 2e-31, bitscore:
                     108.3, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGRLTGKVAFITGAARGQGRAEAVRLAAEGADVIAIDLADSASSY
                     VRYEPATRAELDETVKLVEQQGRRIVARKADVRDLPALEAAVRDGVAELGRLDIVVANA
                     GIVNYGRTWELTEEQWQDLIDVNLTGVWKTVKATVPTLIEQGQGGSVIITSSVAGSKGL
                     PFLAHYASSKHGVVGLAKVLANELGEHDIRVNTVHPHGVATGMTDDSMGDHLATSPTLA
                     PLYMPALPYQMVQPEDVANLVAFLASDEGKYITGSQLNVDMGAINR"
     aSDomain        complement(15232..15753)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_F7P10_RS02095_PKS_KR.1"
                     /evalue="6.30E-12"
                     /label="F7P10_RS02095_PKS_KR.1"
                     /locus_tag="F7P10_RS02095"
                     /protein_end="181"
                     /protein_start="7"
                     /score="37.7"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VAFITGAARGQGRAEAVRLAAEGADVIAIDLADSASSYVRYEPAT
                     RAELDETVKLVEQQGRRIVARKADVRDLPALEAAVRDGVAELGRLDIVVANAGIVNYGR
                     TWELTEEQWQDLIDVNLTGVWKTVKATVPTLIEQGQGGSVIITSSVAGSKGLPFLAHYA
                     SSKHGVVGLAK"
     gene            complement(15923..17212)
                     /locus_tag="F7P10_RS02100"
                     /old_locus_tag="F7P10_02100"
     CDS             complement(15923..17212)
                     /NRPS_PKS="Domain: Abhydrolase_1 (49-217). E-value:
                     2.2e-19. Score: 62.0. Matches aSDomain:
                     nrpspksdomains_F7P10_RS02100_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018655164.1"
                     /locus_tag="F7P10_RS02100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_02100"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_151007820.1"
                     /sec_met_domain="PF00561 (E-value: 6.1e-17, bitscore: 61.0,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIAGTFRQRGLVCTDHVIEVPLDHDRPDGPRIEVYAREVVTAAKA
                     DADLPRLLFLQGGPGGKAVRPASGSGFVGRALDDHRVVLLDQRGTGRSTPANRRTLARL
                     GGPAEQAAYLAHFRADAIVRDAEALRREIGGGRPWTTLGQSYGGFITMAYLSLAPEGLR
                     RSFVTGGLPTLTGTADDVYGLTFDRTLEKNEEYFARHPGDRDLCARIVGHLRERDVRMP
                     TGERLSPRRFQGLGLGLGTRAGFDTLHFLLEEAFVEGPDGPELSDTFLAGVHDATSLAA
                     RPLYALFQEPIYAQGGATNWAAERVYRGRPEFDLEGGAPFAFTGETYYPFNFEEDPALV
                     PLRDTAHLLAAKDDWPRLYDPGRLARNEVPVYAAVYHDDMFVPREFSLETARAVRGLRP
                     WITNEYEHDGLKESTAVLDRLLAMAEEDGA"
     aSDomain        complement(16562..17065)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_F7P10_RS02100_Abhydrolase_1.1"
                     /evalue="2.20E-19"
                     /label="F7P10_RS02100_Abhydrolase_1.1"
                     /locus_tag="F7P10_RS02100"
                     /protein_end="217"
                     /protein_start="49"
                     /score="62.0"
                     /tool="antismash"
                     /translation="PRLLFLQGGPGGKAVRPASGSGFVGRALDDHRVVLLDQRGTGRST
                     PANRRTLARLGGPAEQAAYLAHFRADAIVRDAEALRREIGGGRPWTTLGQSYGGFITMA
                     YLSLAPEGLRRSFVTGGLPTLTGTADDVYGLTFDRTLEKNEEYFARHPGDRDLCARIVG
                     HLRER"
     gene            complement(17212..18303)
                     /locus_tag="F7P10_RS02105"
                     /old_locus_tag="F7P10_02105"
     CDS             complement(17212..18303)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="F7P10_RS02105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="F7P10_02105"
                     /product="hypothetical protein"
                     /protein_id="WP_151007821.1"
                     /transl_table=11
                     /translation="MEVTSRIESRPEYLSYEAALGARKLVEEIMLVKPGEDVVITADSS
                     TDSRVVDVTAQAVAAAGATPTVVWYPTRPSSAMEPPGPVAGAVARSQVWIEYALAYIMH
                     SDAFRAAMAQGTRYANLTGMDVQMLVDTVARVDFQGTIDLGKALVRLLEKADEVRITTP
                     AGTDLRARNGGRPINLRGKPAEKPGETVMLAGQISWNPLEETQEGVLVFDGAVWPPNDL
                     GLIRSPIRMEVSEGTVTSIEGEGTDATVFRRWMEDQVKSADDPEVGRNMYRVAHWSLGF
                     NPGVTQPTGRIVEDERIFGCVELGLGTKGAWIGGDPFLAPAHTDGSLLNPSIYLDGEAI
                     EIEGRYVHPELVEICHRLGIPGY"
     gene            complement(18311..19990)
                     /locus_tag="F7P10_RS02110"
                     /old_locus_tag="F7P10_02110"
     CDS             complement(18311..19990)
                     /GO_function="GO:0035673 - oligopeptide transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013152721.1"
                     /locus_tag="F7P10_RS02110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_02110"
                     /product="OPT/YSL family transporter"
                     /protein_id="WP_151007822.1"
                     /transl_table=11
                     /translation="MTIPSLKGAALRGPESHPRAYEPVVLILTIALSVLGALIGLHLVT
                     TLGISANTSVIGALIAMLVGRVPARKLREMRSVHRQNLVQSAISGATFAAANSLLVPIG
                     VPFVLGRPDLVWPMLLGAGIGLFVDSLVLYRVFDSKLFPARSTWPPGVAAAETIVAGDE
                     GGRKAVVLGIGGLVGFLGSFVKIAGNALPVSAAGVALIGNIWALGMFGVGLGVNQYGQE
                     WFDVDLNEMYIPHGFMVGAGLVALIQAVVLLARRQQEKAEDERAEREERDGRTAVGAQT
                     AEAMRPTVDENGLRRALAHGYVLFVFGALVVALTGGILGDLSVIELIGWCLLAGFAALV
                     HQLIVGLAAMHSGWFPAFAVTLIFMVLGLVIGIPTVPLALFVAYISATGPAFADMGYDL
                     KAGWILRQGGTPYRLVERAGRKQQYIAQLVGFAVALAVVAVTWKSYFEGGEIPPVSKVY
                     ADTVAGGLTDTSTLTNILIWAVPGALIQFIGGPERQMGVLLATGLLILTPYACWFVLGA
                     LAFRIIWARVRGPEAASGELNLIGSGLIAGGSLTDVSRVVKG"
     gene            complement(20001..20777)
                     /locus_tag="F7P10_RS02115"
                     /old_locus_tag="F7P10_02115"
     CDS             complement(20001..20777)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1195: IclR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF013757.4"
                     /locus_tag="F7P10_RS02115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_02115"
                     /product="IclR family transcriptional regulator"
                     /protein_id="WP_151007823.1"
                     /transl_table=11
                     /translation="MGEPGRGTAKTLDRGLLVLLAFQHRTEWGVSELARELGLDKAVAH
                     RLLTTLAHRGFVLADPGTRRYRLGAAVGVLARAAERGGTLEAAARPQLTALARELGESA
                     VLNVPHGAGYRTALAVDAAGPMRYSAIVGETLPAHGGAAGHAIFAFYPDDDVRRLLGAG
                     PLERFSDTTVTDPGELREVYARVRREGVSISHGEYDLNVTSVAAPVFAAGEVVGSLVVI
                     GPHHNVTEKIDTTIARVRGAAGSLSRLLDGGGAEEQ"
     misc_feature    20875..20892
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 13.72"
                     /tool="antismash"
     misc_feature    20982..20996
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: medium, score: 25.68"
                     /tool="antismash"
     gene            21142..22671
                     /locus_tag="F7P10_RS02120"
                     /old_locus_tag="F7P10_02120"
     CDS             21142..22671
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009076788.1"
                     /locus_tag="F7P10_RS02120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F7P10_02120"
                     /product="MDR family MFS transporter"
                     /protein_id="WP_151007824.1"
                     /transl_table=11
                     /translation="MTDPVHAAPAGTDPPAPAARAGLLIGVLVASAFVMILNETILSVA
                     LRDLGEELDVSTTTVQWLTSGFLLTMAVVIPTTGFLLERFTPRRIFLASLTLFALGTLL
                     SGAATGFGMLLAGRVIQACGTAVMIPLLMTTVMRLVPTERRGSMMGTITIVIAVAPAVG
                     PTIGGAVLSSLGWRWMFWIVLPLALAALLIGAIWLRLDSRTRPVPLDVLSVLLSAAGFG
                     GLLYGLSSIGESGGGEHAVPAWAPIAAGAVALAVFVARQLRLQRRGRALLDLRPFTHRS
                     FVVALVLTALLFMCMLGAAAILLPLYLQTVLHTSTFVSGLAVLPGGLALGLLGRPVGAL
                     FDRFGARPLVIPGALAMAVSLWLFTTLGDGSPLGVVIAVHVVLMVGLGMMMTPLMTESL
                     GVLSDDLHSHGSAILATLQQVAGAFGTAVFVTVAAHGSAAGSGAPDEGGLRTAFVVAGC
                     IGLLAVVVSLFVRPAPERAPALPHDGADGAGGAEPPDGAKLPDDGRATRTP"
ORIGIN
        1 gcccggcctc ggccgcaccc gtctcggccg cacccgcctc ggccgcacgg ccatcccggt
       61 ccggggcggt ggcggacgtg gggcgggctc ggcgggcgag ggtcgcggtt tcgcggaggc
      121 cgtcggggtc gacgtccgcc agggccaggc gcatgccctc ggccgccagg cggacggcca
      181 gcgcgcggcc gatcccgctc gccgcgccgg tcaccaccgc gacccggccg tccagttccc
      241 gcatcggacc tcccgccgcc cgcccctgtc ggcggaccgg tcagcacgct aacctcaact
      301 gcatcaagta ttcaatataa ggagtgccat gctccagacc gcggtcgtcg tcaccggcgg
      361 cgcctccggc atcggtgccg cgtgcgcccg ggcgctcgcc gagcacggca ggcccgtcgc
      421 gctgtgggat cgcgccgacg cggcggacgt cgcgcgggac atccgcgcgg acaccgggac
      481 ggccgcgttc tccgcggtcg tcgacgtcac cgacaccgcc gcgttcccgg cggcgctcga
      541 cgcgtcgcgg gaggcgctcg gtccgctcgg cgggctggtg cacgcggcgg gcatcgcggg
      601 cccggccgcg gtcggcgatc tcgacgagga gcgctgggac gccgtccagc acgtcaacct
      661 ccgggcccag gcgctgctcg cgcaggcgat gctggacgac ctgcgggcgc aggagggctc
      721 ggcgatcgtg gggatctcgt cgatcgaggc gttcgtcggc cagctgttca tccccgcgta
      781 ctgcgcctcg aaggcggggc tgctcgggct gacgcggtcg ctggcgcacc tgctggcggg
      841 cgacggcgtc cgcgtgaacg cggtgtgccc gggatacatc gacacgcccc tgctcaccgg
      901 agcggcgccg ccggagatgc gggcggagtt cgcggcgaag gcgccggtcg ggcggctcgg
      961 gcggcccgcg gaggtcgcgg cggccgtccg gttcctgctg agcgaggagg cgtcgttcat
     1021 caccggcacg cacctgacgg tcgacggcgg ctccaccgcc gtcgaccgct gacacggcga
     1081 cccctggcac ggcacccctg acacgacacg ctggaggaca catgggaccc ctggacggga
     1141 cggcggcgct ggtgacgggc ggcggcagcg gcatcgggct gggctgcgcc gtgcggctgg
     1201 ccgcggcggg cgcggccgtc acgatctgcg ggcggacgga gtcgcggctg cgcgacgccg
     1261 tcgagcgggc gggcaaggac gggttcgaga tcgcgcacgt ggtcgccgac gtcaccgacg
     1321 acgcgcaggt cgagaacgcg gtccgggcgg cgggcgagcg cgggccgctg cggacggtcg
     1381 tggcgagcgc gggcgggtcg agctcggtcg ggcccatcgg cgacctcgac ctcgagcagt
     1441 ggcgcgccac gctggagctc aacgcgacgg ggacgatgct cacgatccgg cacgcgtcgc
     1501 gggcgatggc gcgcggcggg ggcggttcga tcgtcgcgat ctcgtcgatc gcggcgtcga
     1561 acacgcaccg gtggttcggc gcgtacgggg tgtccaaggc ggccgtcgac catctcgtgc
     1621 ggctggcggc ggacgaactg ggcggtgccg gcatccgcgt gaacggcgtc cggcccggca
     1681 tcgtccgcac cgagctcgtc gcgggcatcg ccgacaccgg gcccgtcctg gacgactacc
     1741 tgtcgtgcat gccgctgtcc cgggtcggcg aaccggagga catcgccgga gcggtcgcgt
     1801 tcctcgcggg gcccgagtcg tcctggatca ccggccaggt gctgaacgtg gacggcgggc
     1861 accatctgcg gcgggggccc gactactcgt cgttcttcga gccgatgttc ggtgcggacg
     1921 cgctgcgggg cgtcccgccg gaggacccgc ggtgaacgcc cccgggcgac cccggccggg
     1981 cgggtccggg gccgcctgcg accctgtggt catgcgcatc gtcatcgtcg gcggcgggat
     2041 catcggcgcc gccctggccg accgtctcgc ccgcacggcc gaggtgacgc tggtcgagcg
     2101 ggaccggccc ggcgcgggga cctcggccgc gagctacgcg tggctcaacg ccaacgaccc
     2161 cgccgacccc ggctaccacg ccttccgcgt cgcggccctg gacgcctggc ggcggaccgc
     2221 cgccgggttc ggcgatccgg gctggtgccg attcgcgggc aacaccgcct gggccgtcga
     2281 cgaacccgac cgggacgccc tcgccgaccg ggtcgcgcgg ctgcgcgacc tcggctaccc
     2341 cgcgaccctg atcaccgcca cccggctgcg cgacgccgaa ccgtcgctgc gtccgccgcc
     2401 cggcgcggtc atcgcccgct accccggtga ggggcacgcg cacgggtccg ccgccgtcgc
     2461 cgcgctgctc ggccgcgccc gcgacgccgg ggcgcggatc ctcgccgggg cggccgcgac
     2521 acggctgaac gtgcggggcg agcgcgtcac cggcgtccgg acgtccaccg gcgacgacct
     2581 ggacgccgac gtgacgatct gcgccgccgg gtggcggagc cccgccctgc tcgcgaccgc
     2641 cggggtcggt ctccccctcg tcgatcccgc ggcgcccggt tcgtccgcgc ccggcctcac
     2701 cgccacgacc acgcgggtcc ccgggctggt caacggcctc gtccactccc ccggtctcga
     2761 cctgcgtccc accccggagg gcggtctcgt gctggaggcc gccgatctcg acgccgacac
     2821 cgacctcgcg tcctcacagg ccgacctcga cgcccgcgcc gccgaactgc tcgaccgcgc
     2881 ccgcgccctg ttcccgggct gcaccgcccg cctcggcgag gtgcgccgct gcgtccgccc
     2941 gctgcccgtg gacggccgcc cgctggtcgg cccgcagcgg ccaggtctgt acacggtcgt
     3001 cacgcacagc ggcatcacgc tcggcccgta cctcgccggc ctggtcgccg gggaggtcgc
     3061 gggcgagggc gccgaccccg cgctggcgcc ctaccgcccg gaccgcccgc tgcccgagcc
     3121 gtcgtccggg ccgtcgtccg ggccgccgtc cgggccgtcc tgatcgcgcc cggcccggcg
     3181 gaggcggagc gcgtagagga cggcgctgcc ggcgaacagc gcggcggtga ctagtagcca
     3241 gcggccgaga tacgggtcct cggtgcgccc gctcgcggcg gtgtagtccc gctcccgcca
     3301 ctgcgcgatc atcgggaaga acagcaggag cagcagcccg gacgcggcga acgggacccg
     3361 gaggtggttc agcggcgaga cgcgcggcgg tccggcgcgc gtccgggcgc gcccggcccg
     3421 cagcgctccg gtgagcgccc tgtcggcgac cgcgtagagc gggaacagga cgaggtcgtg
     3481 ggcgacgacg catccggcga accacgcgag gacgaacggc caaggcgtcg tcgagaagat
     3541 ccgcagggcg gcgtacccgg cgagggcgaa gcacacggcg agggcgagca cgtgcggcgg
     3601 gccggccccg tagaggcccc gcagccggtc cggcaccgcg cgcacgtcag cgctcccgga
     3661 actcgatgag gcgcacccac ttggtgttgt ggacgccggg cagggcgggg acgatcacgc
     3721 gggcggggtg gccgtggtcg agcgtcaggt cggcgccgcc gacccgcagg gcgagcagcg
     3781 agtcggggtc ggcgacctgg ttggcctgca gggtggcctg gttgaaggcg ccgaaccgct
     3841 ccagcgaccg cacgtgcgcc gacgccggtt ccgggacccc ggcggccgcg gcgagatcgc
     3901 gcagccgcac gcccgtccac gtctgcaccg tcgaccatcc ctcgacgcac gcgatgggga
     3961 gttcggcggt gtgctgcggg agggcgagca gcgcggcccg gtccagttcc acagtccggg
     4021 cgccggtgag aacgagccgc cagcgttccc cggcgtccgc ggcggtgatc cccgcggcgg
     4081 ccgccgtccg gttgaccggg aagtcgccgg gccccggcgc gtagccgccg cgcggtgcca
     4141 gcggcgcgag gcggcgggcc gccgtgccgc cgacggcctg ccccaccgtc aggacggcga
     4201 tgagcaggcc gccgccgccc gcgagcgcca ggacgccgcg gcgggtcatg gtcgccggcc
     4261 gcggggccgc gggcaccagc ccgtccgggt cggggggttc cggacggccg tcgcgcagcg
     4321 cgtcgcggaa cgggcgggaa cgcagcgcgc gcaccatgcg cggcaacttg aggatgacgt
     4381 gggcgacgaa cgcgccgatg aacacccacg cgccgtagta gtgcccctcg tagaagctga
     4441 acccgaagac gtaggtgtac tggatgttca ggacgcccgt cacgatctgg aacaggatcc
     4501 cgcccacgag cagcagcagc gtcagccgtt ccaggacctg cgcgatcgac cggccgggcg
     4561 gccaggcgaa cagtttcggg acgaccgacc acagcttgcc gaggaccacg ggcacgagcg
     4621 ccagccccag caggacgtgc accccctgcg tcacctggta cagccacacc ggacgcgtcg
     4681 gccagtcgaa gtacggcagc cgcagccacc cgacgtccgg cgggaacgcc tgcccgaacc
     4741 gcggcgcgta cgccgcgtac gacagcagcc cggtgacgat cacgacgggc agcgcgacca
     4801 gcagcacggc gccgaacacc gacgtcagcc acggtccgcg cagcgggctc cgccaggccc
     4861 ggctccgccc gagaccgggc gggcgccgcc gctccagcgc ccgccacagc cgcaccggag
     4921 ccccgtagcg ggtgaccccc ggacccgacc cgccatccgg atcatccgga cgcatcgcac
     4981 ccccgcccgc cgccggacat gacgatcatg acgtcatgct aggaaccggt gtgcgaacgt
     5041 tccggacatg gacgaacggg cggcgtccaa gccttggcaa agcaccgccc ggatatgctg
     5101 ggcggcgcgc gcccccggtt ccgggacggc tcgcacggcg gtggggcccg ccgtgcccgg
     5161 ctcgccgggc ggaaccgcgg caccggtgcc gccaacggtc cctgcttgtg gccaacgcgc
     5221 ccggacgccc gggccggcac gagtgggaga cgcgcaccga tgacaccttc tccgcggacg
     5281 ccccgtcccg gcccctcctt cctccgtcgc gaggcggcgg tggtcgcggc ggtctcgctc
     5341 ggcggcgggc tcggcgccgc cgcccgccac ggcgcctcgc tggcctggcc cgcccacggt
     5401 tccgccttcc cctggacgac gctggcggtc aacgcgctcg gctgcgccct gatcggcgtc
     5461 ctcatgaccg tcctcgcccg cgtccgggcg acgcatccgc tggtccggcc cttcctgggc
     5521 accggcgtgc tcggcgggtt cacgacgttc tccgccttcg cggcggacgg ccacggcctg
     5581 ctcgcggacg ggcacgcccg gctcggcctc gcgtacctgg cggccactcc ggtcgtcgcg
     5641 gtcgccgccg cgtggggcgc cgcggccctg acccgccgtc tcgccgcccg taccgtccgg
     5701 gaggcccggt gagctggctg ctcgtcgtcg ccggggggat ggcgggcgcg ccgctgcgct
     5761 acctcgccga ccgggccgtg cgggcccgga acgggtcggc cttcccgtgg gggacgttcg
     5821 ccgccaacgt gctcgggtgc ctggtgctcg gcgtgctgac cggcgcggtc gtgcacggcg
     5881 cggcgtccca cccggtgcag atgctcgccg ggaccgggct gtgcggggcg ctgtcgacct
     5941 actcgacgtt ctcgttcgag acggtgcggc tggcggagtc gggcgcgcgg ctgctcgccg
     6001 ccgcgaacgt cgtcgtgagc gtcgtcgccg ggctcgccgc cgtcgtcgcc ggtatcgcgg
     6061 cggccgaggc ggtctgggcc tgagcgctcg agaatactat tcttgatttt ggagagtgtt
     6121 cataccaccg aggagggcgg cgtgccggtt cgccacgacc actggatagg cggcaggaac
     6181 gagcggccgg cgggcagcgc ctacctgccc accgtggacc ccgcgacacg ggagccgggc
     6241 gacgagatcg cggcgggttc ggcgcccgac gccgaacggg cggtggcgtc cgccgcgggc
     6301 gctcagccgg attgggcgcg catgtcgggg gcggaacggt ccggaacgct gcaccggatc
     6361 ggggacgcga tcgaggcgga cgccggcgcg ctgatggagc tggaacgggc gtgcaccggc
     6421 aagacccccg cgcagctccg catggaggcc gagatgtcgg ccgcctactt ccggtactac
     6481 gcgggcgtgc tgcgcgcaca cggcggccgg acgatcgacc agggcgcccg gcaccacacc
     6541 tacacgcggt tcgagccgtt cggggtcatc gcggcgatca ccccgtggaa cctgccgctc
     6601 aaccaggcgt gccgcgcgct ggccccggcc ctggccgccg ggaacgccgt cgtggccaag
     6661 ccgtcggagt tcacctcggc ctcgacgctg cacctggcac ggctcgccac cgcggcgggc
     6721 ctgccggacg gcctgctcaa cgtcgtgacg ggcaccgggc ccggcgcggg cgcgccgctg
     6781 gccgcgcatc cgggcgtccg gcgcatcacc ttcaccgggt cggtcgccac cggacggcgc
     6841 ctggcgggcg tcgcggccga ccggctcatc ccggtgacgc tggagctcgg cggcaagtcg
     6901 cccctggtgg tgttcgccga cgccgacctc gaccgggccg tcgccgccgc cgtcgcggcc
     6961 gtcgccacca acgccgggca ggtgtgctcg gccaccgcgc ggctgctcat cgaggcgtcc
     7021 gtgcacgacg aggtcgtcgc ccggatcgtc accgcggtcg agaagctcga accgggcacc
     7081 gacttcggtc cgatcatcac cgaggaccag ttcggcaagg tcctcgggca cgtcgacgcg
     7141 gcccgcgccg ccgggctggc gccggtgacg ggcggcgccg cctacaccga gggcccggcg
     7201 gcgcggggcc gctacatccg cccgaccgtg tacgcggccg tgccgcccga cgccgcggtc
     7261 gcgcgcgagg agctgttcgg gcccgttctg gtcacgatgc cgttcaccgg cgaggacgag
     7321 gcgctcgcca tggcgaacga caccgactac gggctcgtcg cggccgtctg gtccggggac
     7381 gtcgcccgcg gcctgcgcct cgccgagcgc atcgacgcgg ggcaggtgtc ggtgaacggc
     7441 ggcccgctca ccatcgagac cccgttcggc gggttcaagg acagcggcca cggacgggag
     7501 aaggggatcg aggccctgca cgagtacggg cagacgaagg cgatcagcct gtcgctggac
     7561 tgacgcgccc gcgcgccccg ccccggcgtg ggaacctggg gacgtgacgt cgttcagtga
     7621 aaggttcagt gaaagcgggc gggtgatggg ccggccgcgc gtgacctcgc ggcccgcgct
     7681 ggagcggctg gccttcgagc tgttcgcccg gcaggggttc gacgagacga ccgtggacga
     7741 catcgcggcg gcggccggga tcgggcggcg cacgttcttc cgctacttcg cgtccaagaa
     7801 cgacctggtg tggggcgact tcgacgagca gttgcggcgg ctgcgcacgc tgctggacga
     7861 ggccgacccg agcacgccga tcatggacgc cgtccgccgc gccgtcgtgg agttcaaccg
     7921 gttcgacccg caggaggtgc cgtggcaccg gcagcggatg gagctgatcc tgacggtgcc
     7981 gaccctgcag gccgacgcga cgctgcggta cgcgtcctgg cggcggatcg tcgccgagtt
     8041 cgtggccgcc cggaccgggc ggcccgcgtc cgcgctggcg ccccggctcg cgggcagcgt
     8101 gatcctcgcc gccgccgtcg ccgcctacga gcactggctg gccgccgcgg acgggacgcc
     8161 cctggccgac ctgctggacg acacgctccg ccgggtggag gccgggttcg ccgagctcgg
     8221 cggccccggg cgctgagcgc cctcaccccc ggcggacggc gtccgcgacg gcctcgccga
     8281 tgaggacggc cgtcgcggcg ggcccgcgca gcggcgcggt cggcaggatg gaggtgtcgg
     8341 ccacgcggag cccccgcacg ccgtgcaccc tcccgcgggc gtcgacggcg gcgcccatcg
     8401 ggacggtgcc gcaggtgtgc tgcgacgtcc cgaggcgggc gcggatccac gcgtcgagca
     8461 cgcggtcgtc gtccaccggg acgggctcga cgggtcccgc gcagacctcg ccgaaggcgc
     8521 cggacgtcac gagcgcgacc gtcgcccgca ccgcctcgcg catccggcgg cggtcggctc
     8581 cggtccgcag gtacccgtag tcgatccgcg gcgggacgtc cgggtcgggc gacactgtgc
     8641 gcaggttccc ggaccgcacg ggcgcctgca ccgacgcgag gaaggccggc ggcatgtccg
     8701 ggacgtccgc cctcccgccg accagccccg ccatcggcac gagcgactgg aggatctcga
     8761 ggtcgcccgc cgccgggccg cccgccgacg gcaggtgcag gacgccgccg agccaggaac
     8821 ccgacggccc gtccatcggc cgccggggcg cccactccac gacgagctgc gggtggtcgc
     8881 tgagcgcggt gcccacgggc aggtcgagga cgaccggtat cccggcgcgc tcgaggtccg
     8941 ccgcgggccc gatccccgac aggtgcagca ggtgcggcgt ggagagggcg cccgcgcaca
     9001 gcacgatctc ccccgcctcc aggaccgtcc cgtccccgac gacgacgccc gccgcccgcc
     9061 cgtcccggac gaccaccgac cgcaccgggc actcccccgc caccgtgagg ttcggccgcc
     9121 cggccgccgc gccgagcagg tacgcgaggc cggtgttgac gcggcggccg tcgaccgcgt
     9181 tggacggcac gggaccgaac cccggcggct cctgagcgtt cttgtcggga tcgtccggat
     9241 accccagctc gcgcgcggcg gcgccgaacg cggccgcggc cgggtggtcc aggcccacgc
     9301 ggcgcaccgg caccggcccc cggccgccgt gcagcgcggt cgccccgtgg tcgaggtcgt
     9361 tctcgagggc gcgcatgaac ggcagcatcc gctcgtaggt ccaggcggcg ccgccggcct
     9421 cctccgccga ccagcggtcg aagtcggcgc gccgggcccg gacgaagtat ccgccgttca
     9481 cggtcgtcga cccgccgagc acccgccccc gcgccgcctc gtacggcatg ccgggcgtga
     9541 gccgcgccgg gaacgtccgg acggccggat gccccggccg cgcgcccggg acgaggcggg
     9601 cgtcgagcag gtcggcgggg aacgcggcgg gcaccggccc cgcctccagc gccagcaccc
     9661 tgcggccggg atcctcgctc agccgagccg cgagcaccgc gccggtgccg cccgcgccga
     9721 ccacgagcac gtccgggcgg cgcccgatca gcaccggtct cccgccatcc ggcccgaccc
     9781 ctttcttttg acactcgatg catttagtat cccaccaagt ccgccggccg tgaagtgcgt
     9841 caccgcgcgc accggccgcc gcacgcgaac gaaggaggac gccatggaca gcgccgcccc
     9901 cgagaaccag aacgccgacg agcgggccga ggagatcgcg gccgccgagt cgctgatcga
     9961 ggaggtctcg atcgacggca tgtgcggcgt ctactaggcc gtgccggcga tcgatctgga
    10021 ccgcgcctgg gacctgcacc cgcaggtctc ggtgcggccc gaacccttcg gcgcgctgct
    10081 ctaccacttc ggcacccgca agctgtcgtt cctcaaggac cggcggctgc tggaggtcgt
    10141 ccggggcctt cgggacgcgg ccacggcacg ggacgcctgc acggcggccg acgtgcccgc
    10201 gtccgatctg ccccggtacg gcgcggcgct cggcgcgctc gccagctcgt ccatgctcgt
    10261 ggaaaggacg ccgtgaccac cgacaccgca agccgcgcga cgcagaccgg cccgacccgc
    10321 ctggtcgacc tgttcgagca cgggctcgac gcgccgatct gcctgacctg ggaactcacc
    10381 tacgcctgca acctgtcgtg cgcgcactgc ctgtccagtt cgggacggcg cgacccgcgc
    10441 gagctctcga cggacgaggc caaggccgtc atcgacgagc tggaggccat gcaggtcttc
    10501 tacgtgaaca tcggcggcgg ggaacccacg gtccggtcgg acttctggga gctgctcgac
    10561 tacgccacgg cgcaccacgt cggcgtgaag ttctccacga acggcgtccg gatcaccccc
    10621 gaggtcgccc ggatgctcgc ggccaacgac tacgtggacg tccagatctc gctggacggc
    10681 gcgacgcccg aggtgaacga cgccgtgcgg ggcgcgggct cctacgacac cgcgctgcgc
    10741 gcgatgcgga acctgtccga cgcgggcatg aagaacttca agctgtcggt ggtctgcacg
    10801 cggcacaaca tcccgcagat ggacgacttc aaggccatcg ccgacgagta cggcgcgcag
    10861 ctccggctga cgcggctgcg cccgtccggc cgcggggcgg acgtgtggga cgagctgcac
    10921 ccgacgcagg cgcagcagcg cgagctgtac gactggctcc tcgcccacgg cgaccaggtg
    10981 ctgaccggcg actccttctt ccacctgtcg gcctacggcg aggcgctgcc gggcctgaac
    11041 ctgtgcggcg ccgggcgcgt ggtgtgcctc atcgacccgg tcggggacgt gtacgcctgc
    11101 ccgttcgcca tccacgacga gttcctcgcg gggaacgtcc gcgagaccgg gggcttcgcc
    11161 cgggtctggc gcgagtcgga cctgttccag ggcctgcggg aaccccagac gggcggcgcc
    11221 tgcgcctcgt gcgacttcta cgacacctgc aagggcggct gcatggccgc caagttcttc
    11281 accgggctgc cgctggacgg gcccgacccc gagtgcgtgc agggccacgg cgagaagctg
    11341 ctcgccggac ggcccgagga ccgctcgggc atccccaagc cgtccggcga ccactcgcac
    11401 cgcaccgcgc cgcgccgccg ccgggaaccg gtcctcgtgc agctcgggcg ccgcaccgac
    11461 atggaccgtc cgccggtgag cgcctgcgag gagaaccccc tcgccgggct gcggatcacc
    11521 tgacccggac caccccacgc gtccaccgga cgcgcccacc cgacgcgccc acccgataag
    11581 aggaagacga catgttccag aacccgtggt tcgagaccgt ggccgaggcg cagcgccggg
    11641 ccaagaggcg gctgccgcac atggtgtacg gggcgctggt cgcgggctcg gagcgcggcc
    11701 ggacggtcgg cgacaactgc aaggcgttcg gcgacctcgg cttcgcgccc cacgtcgcgg
    11761 gccaccacgc ggagcgcgac ctgtccacga ccgtcatggg cgtggagacg tccatgccgg
    11821 tcgtcatctc ccccaccggc gtgcaggccg tgcaccccga cggtgaggtc gcggtggcgc
    11881 gggccgccgc gaaccggggc gtgatcatgg ggctcagctc gttcgcgagc aagcccgtcg
    11941 aggaggtcgc cgaggccaac ccgaacgtct tcttccagat gtactggagc ggcgaccggg
    12001 acgcgatggt gcggcgcatg gaccgcgcgc ggcgcgccgg ggcgaaggcg ctgatcgcca
    12061 cgctcgactg gtcgttctcc aacggccggg actggggcag ccccatgatc ccggagaagg
    12121 tcgacctgaa gacgatggcg aagctggcgc cgggcgtcct gccccacccg ggctggctgt
    12181 ggcggttcgc ccggaccaag cggctccccg acctcacgac ccccaatctc cagccgccgg
    12241 acggccccgc cccgaccttc ttcggcgcgt acggcgagtg gatgcaaacg ccgccgccca
    12301 cctgggagga cgtcgcctgg ctgcgcaagg agtggggcgg cccgttcatg ctcaagggcg
    12361 tcacccgcgt ggacgacgcc aagcgggcgg tcgacgccgg ggtcaccgcc ctgtcggtgt
    12421 ccaaccacgg cggcaacaac ctcgacacga cgcccgcgac gatccgcgtg ctgccgtcgg
    12481 tcgccgaggc cgtcggcgac cagatcgagg tgctgctgga cggcggggtg cggcgcggcg
    12541 gcgacgtcgc caaggcgctc gcgctcggcg cccgggccgt gctgatcggc cgcgcctacc
    12601 tgtggggcct ggcggcgaac gggcaggccg gggtggagaa cgtcctcgac atcatgcgcg
    12661 gcggcctcga ctcggcggtg ctgggcctcg ggcactcctc cgtcggtgag ctgtccccgg
    12721 ccgacctggc ggtcccgccc gggttcgcgc tgacgctggg cggcggggag gactgacgtg
    12781 cgggacctgg ccggcgccgc ctggcccgag gtcggggcgg cctcggtgct ggtgccggtc
    12841 gggtcgaccg agcagcacgg accccacctg ccgctgtcca ccgacaccgt gatcgccgcg
    12901 gccgtcgcgg agcgcgccgc ggccgccctg gacggccccg tgctcgtcgc gcccgccctc
    12961 gcgtacgggg ccagcggcga gcacgccggg ttcccgggca cgatgtcgat cggacgggac
    13021 gcgctggagc tcgtcctcgt cgagaccgtg cggtccctcg cgccgtgggc gggccgggtc
    13081 gtgttcgtca acgggcacgg cggcaacgcc ggggcgctcg acgccgccgc cgggcggatg
    13141 cgcgccgagg ggcacgacgc cgggtgggtc ggctgcggcg tcccgggcgc cgacgcgcac
    13201 gccgggttca ccgagacgtc gatcatgctg tacctggccc ccgagctggt gcgggcgtcg
    13261 cgcgcggtcg cgggcgacac ccggccgctc gccgagctga tgcccgagct ggtcgcccgg
    13321 ggcgtccggg ccgtgtcgcc gacgggcgtc ctcggcgacc cggccggcgc gtcggccgga
    13381 cgcgggcgcg agctggtgga cgcgatggcg gccgcggccg cccggcggat ccgcaccggg
    13441 cgggcggacg cgcgcgggcg gctcctcggt cccggggcgg cgacatgagc gcctcgtccc
    13501 ggttcccgct tccgcccggt ttcccgatcg cgctggacga ggggacgtcg ctgtggtcgg
    13561 gcggccgggt ggcgaccggc ggcgccccgt ggaaggtggt gcggctcgcc gacgccgccc
    13621 gcccgcacct ggcggcgctg gcccgcgcgg gcggcggcgg tctggccgcc tcctcgccca
    13681 ccggccgcgc ggtggcccgg ctgctgctcg accacgggct ggcccggccc gtcccctccc
    13741 cgcgccccgg gccgcacggg gtgaccgtgg tgatccccgc gtacgggcgg ccggacgagc
    13801 tcgcgcgctg cctcgcggcc gtcgagggga tgccggtgat cgtcgtggac gacgcctcgc
    13861 ccgaccccgg accgctgcgc cgcgcggccg ccgccgccgg cgcccggctg gtgcggcacc
    13921 cggtcaaccg cggcccggcc gccgcccgga acacgggcct gcggctggtg gagaccccga
    13981 tcgccgcgct cgtcgactcc gactgccgcc ccgaccccgg ctggctggac gtcctcgtgc
    14041 cgcacttcga cgatccgcgc gtcgcggccg tcgccccgcg cgtccgtccc gaccccggcg
    14101 acccgcggct gctcgcccgc tacgagacgg cgcggtcggc gctggacatg ggcgtccggc
    14161 ccgcgctcgt ccgtccgggc ggccggctcg gcttcgtgcc gacggcgacg ctgctggtgc
    14221 gggtcgcggc ggtgaccgat cccgccttcg acgaggagct gcggctcggc gaggacgtcg
    14281 acttcgtctg gcggctgggc gaccgaggct ggaacgtccg gtacgaaccg gcggcacggg
    14341 tcgcgcacac ggcgcggctg gacccggtgg agtgggcgcg gcggcggcac gagtacggta
    14401 cgtccgccgc cgacctggcg cggcgccacc cgggcaggct cgcaccggcg cgcccgtcgc
    14461 tgtggaacct cgccgtcctg ggcctgctcg cgcggggccg tcccgggctc gccgccgcct
    14521 gcggggcggc cgccgccgcg ctgctggccc ggcggctggc gcggctgccc gccgactgga
    14581 gcctggccgc cgcgatcgtc gggaagggcg tgctcgccga cgccgccgcc ctcgggcacg
    14641 cgctgcgccg cgagtggtgg cccgccggtc tcctcgtcct ggccgcggcg ccgcgccgcc
    14701 gcaccgcccg cgcggcggcc ctggccatgc tcgcgcccat cgcgctcgag tggctgcgcg
    14761 agcgccccga cgtcgacccc gtccggtaca ccgcgctgcg gctcgccgag gacgtcgcct
    14821 acgggtcggg cgtcacggcg gcgtcggtgc gggcgcgctc gtccgctccg ctccgcccgg
    14881 acgtccggct gccggacggg ctctcggcca cgcgcgcggc cggacgggcg agagccgccg
    14941 ggaagcgcct ccgctccgcg ctccggatca gcggttgatc gctcccatgt cgacgttcag
    15001 ctgggaaccg gtgatgtact tgccctcgtc ggacgccagg aacgcgacca ggttcgcgac
    15061 gtcctcgggc tggaccatct ggtagggcag cgcgggcatg tagagcggcg cgagggtcgg
    15121 cgacgtggcg aggtggtccc ccatcgagtc gtcggtcatg ccggtggcga cgccgtgcgg
    15181 gtggacggtg ttgacgcgga tgtcgtgctc gcccagctcg ttcgcgagca ccttggccag
    15241 cccgacgaca ccgtgcttgg agctggcgta gtgggcgagg aacggcagcc ccttcgagcc
    15301 cgccaccgag ctggtgatga tgaccgagcc gccctgcccc tgctcgatga gcgtgggcac
    15361 ggtggccttg accgtcttcc acacgccggt gaggttgacg tcgatgaggt cctgccactg
    15421 ctcctcggtc agctcccagg tccggccgta gttcacgatc cccgcgttgg cgaccacgat
    15481 gtccagccgg cccagctcgg cgacgccgtc ccggacggcc gcctccagcg cgggcaggtc
    15541 gcggacgtcg gccttgcggg cgacgatccg gcggccctgc tgctcgacga gcttgacggt
    15601 ctcgtccagc tcggcccgcg tcgcgggctc gtagcggacg tacgagctgg ccgagtcggc
    15661 gaggtcgatc gcgatgacgt cggcgccctc ggcggcgagc cgcacggcct cggcccggcc
    15721 ctgcccgcgc gcggcaccgg tgatgaaagc gaccttgccc gtcaaacgtc ccatgggaaa
    15781 cctccgtgtc ggcagcgggt ccgctcatga tggcactcag tgccaaaaag agcaatgacc
    15841 ctcccgacct gcgtttcgcc gcacggaggc ggcgaagggg aggccgcggg cccgcggcct
    15901 ccccgggacg cgacgtgtcc cgctaggcgc cgtcctcctc cgccatggcg aggaggcggt
    15961 cgaggacggc ggtgctctcc ttcagcccgt cgtgctcgta ctcgttggtg atccacggcc
    16021 gcagcccgcg caccgcgcgc gccgtctcca gggagaactc gcgcgggacg aacatgtcgt
    16081 cgtggtagac cgccgcgtag acgggcacct cgttgcgggc gagccggccc gggtcgtaca
    16141 ggcggggcca gtcgtccttc gcggccagca ggtgcgcggt gtcgcgcagc ggcacgagcg
    16201 ccggatcctc ctcgaagttg aacgggtagt acgtctcgcc cgtgaaggcg aacggggcgc
    16261 cgccctccag gtcgaactcc ggacgccccc ggtagacgcg ctcggcggcc cagttcgtcg
    16321 ccccgccctg cgcgtagatc ggctcctgga acagcgcgta gagcggccgg gcggcgaggc
    16381 tggtcgcgtc gtgcacgccc gcgaggaacg tgtccgagag ttcggggccg tccgggccct
    16441 cgacgaacgc ctcctcgagg aggaagtgca gcgtgtcgaa gccggcgcgg gtgccgagcc
    16501 cgaggccgag gccctggaag cggcgcggcg acagccgctc gcccgtgggc atccggacgt
    16561 cgcgttcccg gagatgcccg acgatgcggg cgcacaggtc gcggtcgccg gggtggcggg
    16621 cgaagtactc ctcgttcttc tccagcgtcc ggtcgaacgt gagcccgtag acgtcgtcgg
    16681 ccgtcccggt gagcgtcggc aggccgccgg tgacgaacga gcgccgcagc ccttcgggcg
    16741 ccagcgacag gtacgccatc gtgatgaacc cgccgtagct ctgcccgagc gtcgtccacg
    16801 gccgcccgcc gccgatctcg cggcggagcg cctcggcgtc ccggacgatc gcgtcggcgc
    16861 ggaagtgcgc gaggtacgcg gcctgctcgg ccgggccgcc gaggcgggcg agggtccgcc
    16921 ggttcgcggg cgtggaccgg ccggtgccgc gctggtcgag cagcacgacg cggtggtcgt
    16981 ccagggcgcg cccgacgaac ccgctcccgg acgcgggccg caccgccttg ccgccggggc
    17041 cgccctgcag gaacagcagc cggggcaggt cggcgtcggc cttcgcggcg gtgacgacct
    17101 cgcgcgcgta cacctcgatg cgcgggccgt ccggacggtc gtggtcgagc gggacctcga
    17161 tgacgtggtc ggtgcagacc aggccccgct gccggaacgt tccagcgatc atcagtagcc
    17221 cgggatcccg agccggtggc agatctcgac cagctcgggg tgcacgtagc ggccctcgat
    17281 ctcgatcgcc tcgccgtcca ggtagatgga cgggttgagc aggctgccgt cggtgtgcgc
    17341 gggggcgagg aacgggtcgc cgccgatcca ggcgcccttc gtgccgaggc ccagctcgac
    17401 gcagccgaag atgcgctcgt cctcgacgat ccggccggtg ggctgcgtga cgccggggtt
    17461 gaacccgagc gaccagtgcg cgacccggta catgttgcgg ccgacctcgg ggtcgtcggc
    17521 ggacttcacc tggtcctcca tccagcggcg gaagaccgtc gcgtcggtgc cctcgccctc
    17581 gatcgaggtg acggtgccct cgctgacctc catccggatc ggggagcgga tcaggcccag
    17641 gtcgttcggc ggccagacgg cgccgtcgaa caccagcacg ccctcctggg tctcctccag
    17701 agggttccag gagatctgcc cggccagcat gacggtctcg cctggcttct cggcgggctt
    17761 gccccgcagg ttgatcggcc ggccgccgtt gcgggcgcgc aggtcggtgc ccgcaggggt
    17821 ggtgatgcgc acctcgtcgg ccttctccag cagccggacg agcgccttgc cgaggtcgat
    17881 cgtcccctgg aagtccaccc gcgccacggt gtcgacgagc atctggacgt ccatgccggt
    17941 caggttcgcg tagcgggtgc cctgcgccat cgccgcgcgg aacgcgtccg agtgcatgat
    18001 gtacgcgagc gcgtactcga tccacacctg cgaacgggcg accgcgcccg cgaccgggcc
    18061 gggcggctcc atcgccgagg acggccgggt cgggtaccac acgaccgtcg gcgtcgcccc
    18121 ggccgccgcg accgcctgcg cggtgacgtc cacgacccgg gagtcggtgg agctgtccgc
    18181 ggtgatcacg acgtcctcgc ccggcttgac gagcatgatc tcctcgacga gcttgcgggc
    18241 gccgagcgcg gcctcgtacg agaggtactc gggccgggac tcgatccggc tggtgacttc
    18301 cacttcgtcc ttatcccttc actacgcggc tgacatcggt gagcgagcct ccggcgatca
    18361 gtcccgaacc gatcaggttc agctcgccgc tcgcggcctc gggtccgcgc acccgggccc
    18421 agatgatcct gaaggccagc gcgccgagca cgaaccagca ggcgtacggg gtgaggatca
    18481 gcagtccggt cgccagcagc acgcccatct gccgttccgg cccgccgatg aactggatga
    18541 gcgcgccggg caccgcccag atcaggatgt tggtgagcgt ggaggtgtcg gtgaggccgc
    18601 ccgcgacggt gtcggcgtag accttcgaca ccggcgggat ctcgccgccc tcgaagtagg
    18661 acttccaggt caccgcgacc acggcgagcg cgacggcgaa gccgacgagc tgcgcgatgt
    18721 actgctgctt gcgcccggcc cgctcgacga gccggtacgg ggtgccgccc tgccgcagga
    18781 tccagcccgc cttcaggtcg tagcccatgt cggcgaacgc gggaccggtc gcggagatgt
    18841 aggcgacgaa cagcgccagc ggcaccgtcg ggatcccgat caccaggccc agcaccatga
    18901 agatcagcgt gaccgcgaac gccgggaacc agcccgagtg catcgcggcc aggccgacga
    18961 tcagctggtg caccagtgcg gcgaagcccg cgagcaggca ccagccgatc agctcgatca
    19021 ccgacaggtc gccgaggatc ccgccggtca gcgccacgac gagcgccccg aagacgaaca
    19081 ggacgtaccc gtgggcgagc gcccgccgca gcccgttctc gtccacggtg ggccgcatgg
    19141 cctcggcggt ctgcgcgccc acggccgtgc ggccgtcccg ctcctcgcgc tcggcccgct
    19201 catcctcggc cttctcctgc tgtcggcgcg cgagcagcac gaccgcctgg atcagggcga
    19261 cgagcccggc gccgaccatg aagccgtgcg ggatgtacat ctcgttgagg tcgacgtcga
    19321 accactcctg gccgtactgg ttcacgccca gcccgacgcc gaacatgccc aacgcccaga
    19381 tgttgccgat cagcgcgacg cccgccgccg agaccggcag cgcgttcccg gcgatcttga
    19441 cgaacgagcc gaggaagccg accaggccgc cgatgccgag cacgacggcc ttgcggccgc
    19501 cctcgtcccc ggccacgatc gtctccgccg cggcgacgcc gggcggccac gtggagcggg
    19561 ccgggaacag cttggagtcg aacacccggt acagcaccag ggagtcgacg aacagcccga
    19621 tcccggcgcc cagcagcatc ggccagacca ggtcggggcg gcccaggacg aacgggacgc
    19681 cgatcggcac cagcagcgag ttcgcggcgg cgaacgtggc gccggagatg gcgctctgca
    19741 ccaggttctg ccggtgcacc gaccgcatct cgcgcagctt gcgggccggg acccggccca
    19801 ccagcatcgc gatcagcgca ccgatgaccg aggtgttggc cgagatgccg agcgtcgtca
    19861 ccaggtgcag gccgatgagc gcgccgagca ccgacagggc gatggtgagg atcaggacga
    19921 ccggctcgta cgcgcggggg tgcgattccg gcccgcgcag ggccgccccc ttcaacgatg
    19981 ggatggtcac aggctcttcc tcactgctct tcggccccgc cgccgtcgag caggcggctc
    20041 agcgaccccg ccgcgccgcg cacccgcgcg atggtggtgt cgatcttctc cgtgacgttg
    20101 tggtgcgggc cgatcacgac cagcgagccg acgacctccc cggcggcgaa caccggcgcc
    20161 gcgaccgagg tgacgttgag gtcgtactcc ccgtgcgaga tcgagacccc ctcccggcgg
    20221 acccgcgcgt agacctcgcg cagctcgccg gggtcggtga ccgtggtgtc gctgaaccgc
    20281 tccagcggtc ccgcgcccag cagccgccgg acgtcgtcgt ccgggtagaa cgcgaagatg
    20341 gcgtgcccgg cggcgccgcc gtgggccggg agcgtctccc ccacgatggc cgagtaccgc
    20401 atgggcccgg cggcgtccac cgccagcgcc gtccggtagc cggcaccgtg cggcacgttc
    20461 agaacggcgc tctcgcccag ctcgcgggcg agcgcggtga gctgcggccg ggccgccgcc
    20521 tccagcgtcc cgccgcgctc cgcggcccgc gcgagcacgc cgaccgccgc gccgagccgg
    20581 taccgccggg tgccggggtc ggccagcacg aacccgcggt gcgcgagcgt cgtcagcagc
    20641 cggtgcgcga ccgccttgtc gagccccagc tccctggcca gctcgctgac cccccattcc
    20701 gtccgatgct ggaaggccag cagcaccagc agcccccgat cgagggtctt ggccgtaccg
    20761 cgtcccggct cgcccaccgc gaccaccttt ctgttgcgtt tatcgcaaca gcgttgctat
    20821 ttctgagccg cactgtatcc gctggtcagt cattacggtc aagcccgaat ggggacgtaa
    20881 cgcggttttt actcgcgggg gtgcgctggg cgagccccgc cccgccgccg tctagactcg
    20941 tcgggatggt cacatcccga accccggtgc ccgccgcgcc gaggccgtcc ggccccggca
    21001 cctgcaccgg tccgccgccg gccggcgctc gctgaccgac cgtcccgtcc gtcccgtccg
    21061 taccgtccgt tccgccgccc gccgggcgat gcccaccgca tcgaggcccg gtctcccgcc
    21121 gcccccacga ggtgcttctc catgaccgat cccgtgcacg ccgcccccgc gggcaccgac
    21181 cctccggccc cggccgcgcg ggccggcctg ctgatcggcg tcctggtcgc ctcggccttc
    21241 gtgatgatcc tgaacgagac gatcctgagc gtcgcgctgc gggacctggg cgaggaactc
    21301 gacgtctcca ccacgacggt gcagtggctg accagcggat tcctgctgac catggccgtg
    21361 gtgatcccga ccacggggtt cctgctcgag aggttcaccc cgcgccggat cttcctggcc
    21421 tcgctgaccc tgttcgccct gggcacgctg ctcagcgggg cggccaccgg cttcgggatg
    21481 ctgctggccg ggcgcgtgat ccaggcgtgc ggcaccgcgg tgatgatccc gctgctgatg
    21541 accacggtga tgcgcctggt accgaccgag cggcgcggct cgatgatggg cacgatcacc
    21601 atcgtcatcg ccgtcgcgcc cgcggtcggg ccgaccatcg gcggggcggt gctgtcctcg
    21661 ctggggtggc gctggatgtt ctggatcgtc ctcccgctgg cgctcgccgc gctgctcatc
    21721 ggtgcgatct ggctgcggct cgattcccgg accaggccgg tgccgctgga cgtcctctcg
    21781 gtgctgctgt ccgcggccgg gttcggcggt ctgctgtacg ggctgtcctc catcggggag
    21841 tccggcggcg gggagcacgc cgtgccggcg tgggcgccga tcgcggccgg ggccgtcgcg
    21901 ctcgccgtgt tcgtggcgcg gcagctgcgg ttgcagcgcc gcggccgggc cctgctcgac
    21961 ctgcgcccgt tcacccaccg cagcttcgtg gtcgccctcg tcctgaccgc cctgctgttc
    22021 atgtgcatgc tgggcgccgc ggcgatcctg ctgccgctgt acctgcagac cgtcctgcac
    22081 accagcacgt tcgtcagcgg gctggccgtg ctgccgggcg ggctggccct cgggctcctc
    22141 ggacgtcccg tcggtgcgct gttcgaccgg ttcggggccc gtcccctggt gatccccggt
    22201 gccctggcca tggcggtgtc gctgtggctg ttcaccacgc tcggggacgg ctcgccgctg
    22261 ggcgtggtca tcgccgtgca cgtcgtgctc atggtcgggc tcgggatgat gatgaccccg
    22321 ctgatgaccg agtcgctcgg ggtgctctcc gacgacctgc actcccacgg cagcgccatc
    22381 ctcgccacgc tccagcaggt cgcgggcgcg ttcggcacgg ccgtgttcgt caccgtcgcc
    22441 gcgcacggca gcgccgccgg ctccggcgcc cccgacgaag gcggcctgcg caccgcgttc
    22501 gtcgtcgccg ggtgcatcgg cctgctcgcc gtggtcgtgt cgctgttcgt ccgcccggcc
    22561 cccgagcgcg ctccggccct gccccacgac ggcgcggacg gtgcgggcgg cgcggagccg
    22621 ccggacggcg cgaagctgcc ggacgacggg cgggcgacgc ggacaccatg aaggcgggag
    22681 caccgtgaac cggccccgcg gcaacccgcg agggggaggc gcccgtgacg gctgaaccgg
    22741 atccgccgcg ccgccggcgc ggccgccccg gctacg
//
