LOCUS       NZ_CP031598            23039 bp    DNA     circular CON 28-MAR-2024
DEFINITION  Roseovarius indicus strain DSM 26383 chromosome, complete genome.
ACCESSION   NZ_CP031598
VERSION     NZ_CP031598.1
KEYWORDS    RefSeq.
SOURCE      Roseovarius indicus
  ORGANISM  Roseovarius indicus
            Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
            Roseobacteraceae; Roseovarius.
REFERENCE   1  (bases 1 to 5445172)
  AUTHORS   Vollmers,J. and Petersen,J.
  TITLE     Genetic Globetrotter - A new plasmid hitch-hiking vast phylogenetic
            and geographic distances
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 5445172)
  AUTHORS   Petersen,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (12-AUG-2018) Single Cell Genomics, Leibniz Institute
            DSMZ, Inhoffenstr. 8, Brunswick 38126, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: FEB-2018
            Assembly Method                   :: HGAP v. 3
            Assembly Name                     :: DSMZ_RIdsm
            Expected Final Version            :: yes
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: PacBio RS; Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_008728195.1-RS_2024_03_28
            Annotation Date                   :: 03/28/2024 05:52:02
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,061
            CDSs (total)                      :: 6,008
            Genes (coding)                    :: 5,925
            CDSs (with protein)               :: 5,925
            Genes (RNA)                       :: 53
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 47
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 83
            CDSs (without protein)            :: 83
            Pseudo Genes (ambiguous residues) :: 0 of 83
            Pseudo Genes (frameshifted)       :: 24 of 83
            Pseudo Genes (incomplete)         :: 57 of 83
            Pseudo Genes (internal stop)      :: 17 of 83
            Pseudo Genes (multiple problems)  :: 15 of 83
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:57:17
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1739847
            Orig. end                         :: 1762886
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP031598.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..23039
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="8"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..23039
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23039
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13039](+)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..13039
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     misc_feature    76..88
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 19.6"
                     /tool="antismash"
     gene            complement(367..1281)
                     /locus_tag="RIdsm_RS07970"
                     /old_locus_tag="RIdsm_01603"
     CDS             complement(367..1281)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="RIdsm_RS07970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="RIdsm_01603"
                     /product="hypothetical protein"
                     /protein_id="WP_143100399.1"
                     /transl_table=11
                     /translation="MAKDTDKLDICLHLGAHKTATTYLQKRLDKNRDGLSEAGVQLFLP
                     KDIRGKIGLKLPSPRQSDARNLQRCADTGQRLRRMIRNGVEDKPRAKRVIVSEENLIGS
                     CKNNLILKGLYPDIAMRLSLLSELFNHSSVSVYFAVRAYSKFFSSNYTSALRNGTLLEK
                     DEVAASLWPLSRSWVDVVTELKAALPRAKLMIWRYEDFGQTEPNILASLAAGTDLVSLD
                     NRPLPTLSMDAVSWLERKIQHGSFQLAPGKVSRRAMARHPATATNPAFTLWSSEMTSEL
                     DERYEADWKEITSKWPSAIQLPN"
     misc_feature    complement(1295..1310)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 20.5"
                     /tool="antismash"
     gene            complement(1323..2333)
                     /locus_tag="RIdsm_RS07975"
                     /old_locus_tag="RIdsm_01604"
     CDS             complement(1323..2333)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /GO_process="GO:0015074 - DNA integration [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018302935.1"
                     /locus_tag="RIdsm_RS07975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RIdsm_01604"
                     /product="tyrosine-type recombinase/integrase"
                     /protein_id="WP_057814225.1"
                     /transl_table=11
                     /translation="MDYNFDRDAERLETVVKLAHAPSETREALIAEYRKRSEAAFAKET
                     LRNYRQITQNFRDWCSEHGHNPDPPVDPRAVAEYVDYLGGKVKCTTIETRLWAISEMHR
                     ATFQPTPCRHRLVELALKGVKRKYGAWVRQAPPLCKAEVYKAIQKLGNSRQHIRDKAVL
                     WVATDSWCRSSEIVAFKVRDLIRQDDGSSLLFVAKSKTDQFGQGAYAFLSEQGTAAVLE
                     WIELAGLKSEDPLLTKSQANARIAPMDPATISRIIKRCTGRKDVSAHSTRVGGVHDAFR
                     IGCDLSSIMVAGRWTSPEMPARYGRRILASNSAAAKVSREFARKSLTCNAGSSDG"
     gene            2605..3258
                     /locus_tag="RIdsm_RS07980"
     CDS             2605..3258
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="RIdsm_RS07980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_143100400.1"
                     /transl_table=11
                     /translation="MDSDQLWINKENPFLHSRFGCATFESPKRWWFKNNEGQMRLRNLT
                     TIFVAVCALAACDSYSAQQYQSSPQNVIALQSLAKQGVRASVGTVQVAEGVNAQPTCRL
                     AGPLDLGGGQSVTETVKEAIQSEFLASNIYSPSGTPISVVITQLKPSSFEGTWTISMQV
                     SSQRGKGYSVTTNTKFSTSFSAMAACNNTAQAFNRALSAAINDMVTDPRFRSLL"
     gene            complement(3611..>3772)
                     /locus_tag="RIdsm_RS07985"
                     /pseudo=""
     CDS             complement(3611..>3772)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011749525.1"
                     /locus_tag="RIdsm_RS07985"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="GLRRDQAAVAAALREPWSNGQTEGQINRLKTLKRQMYGQANIDLL
                     RARLVEVS"
     gene            3963..>4385
                     /locus_tag="RIdsm_RS07990"
                     /pseudo=""
     CDS             3963..>4385
                     /GO_function="GO:0000150 - DNA strand exchange activity
                     [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_032490240.1"
                     /locus_tag="RIdsm_RS07990"
                     /note="internal stop; incomplete; partial in the middle of
                     a contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="helix-turn-helix domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MGLLSVIRRWALRDKMPIREIARRTGLSRNTIKKYLRAGIVEP"
     misc_feature    complement(4563..4576)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 17.04"
                     /tool="antismash"
     misc_feature    complement(4745..4761)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 20.78"
                     /tool="antismash"
     gene            4906..5274
                     /locus_tag="RIdsm_RS07995"
                     /old_locus_tag="RIdsm_01605"
     CDS             4906..5274
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="RIdsm_RS07995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="RIdsm_01605"
                     /product="hypothetical protein"
                     /protein_id="WP_143100401.1"
                     /transl_table=11
                     /translation="MSTFSIALAALSCVFYAMIPSSGFNRFWIAAIGGCVNVIVAVLVW
                     FAIRLGSLSDAFFVLSMGPGEVWSTIVLFSRNIAFSLNGSELTGESLLYIFWVPELVLL
                     FLFPVIMSRFGSGLSGLR"
     gene            complement(5371..6309)
                     /locus_tag="RIdsm_RS08000"
                     /old_locus_tag="RIdsm_01606"
     CDS             complement(5371..6309)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="RIdsm_RS08000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="RIdsm_01606"
                     /product="Crp/Fnr family transcriptional regulator"
                     /protein_id="WP_057814219.1"
                     /transl_table=11
                     /translation="MIEHHDLNLDAYLSAHALFKAIPYDMYAAIRELGSFEVFRQGEPV
                     FPPRSDIDRLLFVVTGRVTYTKAGHVVDRGPGEVFGLWTDEYALSENGAEAAEDSTLIS
                     LDRDVVTYLCQSDMNLVNLFVMEGTLRKSHALSLPDVQRTRLLEVMAHTVAIDEDIDKR
                     EHNFLTHMAGFLDIPLNTLDLSMGSIQHSLRLIQVFRELTRADGEYGLCEFVFGLVNLV
                     ASLDDQISKAEVAMLNELRMHLAGAAERFCITVEIATGDEAGAVPDLPFVLREEAAIRI
                     SDLRSQAMAYYLASRFEKLGQTVKVEEDVAA"
     gene            complement(6306..8768)
                     /locus_tag="RIdsm_RS08005"
                     /old_locus_tag="RIdsm_01607"
     CDS             complement(6306..8768)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012869.4"
                     /locus_tag="RIdsm_RS08005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RIdsm_01607"
                     /product="ABC transporter ATP-binding protein/permease"
                     /protein_id="WP_143100402.1"
                     /transl_table=11
                     /translation="MNEAVVKTRSESRMQSNFEISRLMPIFAAPYLRKFLIVIAFGLLA
                     AGLVYLENTALLLMIQSLSDDRPDDQGGLMGAIRTAVQHQAVQPWAGFLILFVVVSLLK
                     IAASGAGHILQTQMNTRSKSDLEAAVFANLLRKDDGFFQNTSLGEIGNRMVFDIRRVCE
                     RRDHLVDLIFQVLLLLSTFLFFLSVDVLVAAATFGAMVLCALISVQLAKPLPSIDQKFA
                     VLEDGGKEIVIDNLGLRGIAQVVRIAPNMFRRLSAHQAKRDRTYLRFFLHHQTLVSWNT
                     LSYVLSLAMIVVALLWGVGDDATQIALIPVVIKVLPELFSGLSAIIQARALLQLGGNSV
                     ERLGEYASQEENGPESEEAAMPDGVSGTRLEVRDLGFGYDKPIVADASFDLEQGRWYTL
                     MGPSGSGKSTLINLLLGRMPQDKGTITGRDKSGAALDRIRISYMPQQVNLVSGNVRDNI
                     EIAVPEGELDEEMMLQAVQKSGVAQFCFQNILDQPPNDDWPVNSGNISELRAELATHLA
                     AMKGLHLVPSKRNDGAVLLIEKLTGLHIDHADLTLDRLVALGQEAPHDWPALRRLGQHI
                     LERWDWSLRNLDSHDIYVRLTNNILDEHVWALRRAAMGLVRIEESEDQALLLIASALSA
                     RVDEFPGVPLEQVLDAESREYLIGWIRQRNLSRDTGDPDLMDINLSLRDNLIAGRVVVR
                     NKRIEDTIDQMILDVLETRFARNDLLHWSLGAGIGKGGQRLSGGQRQLVAICRCLACES
                     DLYVMDEPTSALDEQARNRIVAMLHDLKRKAIILTITHDQFVGRRSDRTLLLEKAKVTE
                     KVNESVAR"
     misc_feature    8820..8830
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.79"
                     /tool="antismash"
     misc_feature    complement(8863..8879)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 19.71"
                     /tool="antismash"
     gene            8915..9082
                     /locus_tag="RIdsm_RS30060"
     CDS             8915..9082
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="RIdsm_RS30060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_160325816.1"
                     /transl_table=11
                     /translation="MESKIFESREQDHHFSSKTSDVVTTETAIANTSGQAPRAMGTGFS
                     TCPAKTGKYC"
     gene            9165..10001
                     /locus_tag="RIdsm_RS08010"
                     /old_locus_tag="RIdsm_01609"
     CDS             9165..10001
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025007.4"
                     /locus_tag="RIdsm_RS08010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RIdsm_01609"
                     /product="cupin-like domain-containing protein"
                     /protein_id="WP_074940032.1"
                     /transl_table=11
                     /translation="MHTETGCEKDLRRVRQFDGVPDLACFTEQLHYNLEPVVLRNSCFD
                     WQPVREWSPERLEGKLADQMLRISSSASGYFPDTGSTCREKLSGRAFFERLKDEAAGRS
                     PRYSYLDGSETFFNLGGESSSALVALEPEARPPRAVLSPFLVKSALWIGGGGVHSGLHY
                     DGNGCNNFNVQVCGRKSIILLSPKYIDRLSMLSPDKFAHLGHFSGLSLDRDDMAGHPAF
                     SELTLYHAVLDPGDVLFIPALWFHAVTSLEAFNANVNFWTLPDSTYLTPLLKDLVT"
     gene            10001..13039
                     /gene="lanM"
                     /locus_tag="RIdsm_RS08015"
                     /old_locus_tag="RIdsm_01610"
     CDS             10001..13039
                     /GO_process="GO:0009403 - toxin biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0018193 - peptidyl-amino acid modification
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="lanM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03897.1"
                     /locus_tag="RIdsm_RS08015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RIdsm_01610"
                     /product="type 2 lanthipeptide synthetase LanM"
                     /protein_id="WP_057814214.1"
                     /sec_met_domain="DUF4135 (E-value: 5.1e-68, bitscore:
                     228.2, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 4.2e-19, bitscore:
                     66.8, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSRAQMQSIAAGALSLEERWAFPGSTRRPCDAETLANWYEALNG
                     AMPQRLHLAGQEGTDPADLLFEIDPAGIDPLPAWVVALNSALCDLGSSAERRVVAPPGS
                     PSLSPEPFEELLWPLARTLADDWTAEQKRLLSEVARFQARHALLRRLARQTERSLGVVF
                     ANYRASHTEAGAYGRFIALMRQGGFGQYLLAYPVAARAIMRTVDNWHSALQEMIERLAR
                     DQSALKRLTGTSAIFPIRDIDFELSDPHDGERSVARLTLAAGKSVHYKPRPIEAEHVLA
                     SVARKFEDFDPARFSLPCPAMIARPDCGWVETITQTDLPEDVPPSLYFRRFGHWLGLMH
                     VLQGGDIHPDNVVACGAHPHIVDAEVLLQGVLSENNFFIDAARDPALRALSYSTIHTGM
                     LPSFAVKEDGQTTDQSGWYLPQANDLNRLRQRWAEINSDDMHLADETGPRATHHLPTIG
                     GRQVGAREHAADIVVGLREILEASLDLRDPVAVELDRLMASGTIATRFVFRDTQVYGAM
                     LDRLADPPAQRSGLARSIRLETLARVLKSPKTGSVVPALLRSELTALERGDVPLFRTFV
                     ASGEILSRRQVIVTNAFGPTGVQWVKTRLAALAPASIAREADIVSSAYMATHDKSPAPP
                     RDSGGSANFRELAVPEMERLTTLLSRTALQDDGDALNWLAIQPVGTEGRTHVAPLDTSL
                     YDGLAGIALALAVSADVTRSRMAATLCEGSLKTIAHKLSAGDLAEVGPGYGEGVGGVLA
                     ASAQIASLFPNMIARQVIDQIATALERGQELETWDVEDLYGGIAGLILGLGAVEPVLGR
                     ARTAVLMKRAFKRLKLLLARPQSDTTGRAWGSGMAHGAGGIAAAQAMLQSFGVLGPHEN
                     LPESGESGAPASTDDEKPARATSWCHGAGGLALDTSILQRAAGCGPDHLCCGEAGRLDS
                     RLALGDDVEPLRREAAGMVSAAQGSVGYRFYLRGPDTLKPGLFTGHAGIIYLLARLHDP
                     DRYDSILPRMTLTRAPRPKKEIA"
     gene            13036..13788
                     /locus_tag="RIdsm_RS08020"
                     /old_locus_tag="RIdsm_01611"
     CDS             13036..13788
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF019619.4"
                     /locus_tag="RIdsm_RS08020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RIdsm_01611"
                     /product="cupin domain-containing protein"
                     /protein_id="WP_057814213.1"
                     /transl_table=11
                     /translation="MKDFNKPTLADLLGDMTADTFRTNYNNARTVHLPGAMSDQRHHLD
                     FSELRALVENLDNAAEYWLDEAGVERSVSLDGKTAWQRAQEGCTLICNGLSRVSEPARA
                     LSESMIDGLDGEGWPGARLFYSTAFDYGYASHLDPFATFTVQVSGRKRWFASPTPERFD
                     VQKLSHSVIMPAPGEIEEMPFFTFRHREETDMQSFDLMPGDVLYFPAGTWHRAVSLEPS
                     LSVAIDIRPRILPEPEFEATVIRHPPPD"
     CDS             complement(14071..14292)
                     /gene="allorf_1753918_1754139"
                     /locus_tag="allorf_1753918_1754139"
                     /protein_id="allorf_1753918_1754139"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MIDDVTIHAAPSESTLGSRSTASRPFALAAANASFPEELSRKMTN
                     PGSWGRTSAFPICAISRGRAAKVSFPPI"
     CDS_motif       complement(14263..14292)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MIDDVTIHAA"
                     /locus_tag="allorf_1753918_1754139_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(14071..14262)
                     /prepeptide="core"
                     /locus_tag="allorf_1753918_1754139_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-2.40"
                     /molecular_weight="6325.1"
                     /monoisotopic_mass="6321.4"
                     /core_sequence="PSESTLGSRSTASRPFALAAANASFPEELSRKMTNPGSWGRTS
                     AFPICAISRGRAAKVSFPPI"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MIDDVTIHAA"
                     /leader_location="[14262:14292](-)"
                     /alternative_weights="6343.1"
                     /alternative_weights="6361.1"
                     /alternative_weights="6379.2"
                     /alternative_weights="6397.2"
                     /alternative_weights="6415.2"
                     /alternative_weights="6433.2"
                     /alternative_weights="6451.2"
                     /alternative_weights="6469.3"
                     /alternative_weights="6487.3"
                     /alternative_weights="6505.3"
                     /alternative_weights="6523.3"
                     /alternative_weights="6541.3"
                     /alternative_weights="6559.4"
                     /alternative_weights="6577.4"
     gene            complement(14312..15646)
                     /locus_tag="RIdsm_RS08025"
                     /old_locus_tag="RIdsm_01612"
     CDS             complement(14312..15646)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="RIdsm_RS08025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="RIdsm_01612"
                     /product="hypothetical protein"
                     /protein_id="WP_177228396.1"
                     /transl_table=11
                     /translation="MASTLRRIKGSVTVQGETSSNPSDRTFFALAAANKDKFAVGLFGD
                     MMQRIFLDGHPELERLVPDDWARPVKRMNHRSPQRVIALGNVLRAPIDRQSQVARDDSD
                     VGLVRLFVASSSSPDKPALERQVQDRMAEFCNDPNWRDQAGVKALTLEHHMAASRYGFL
                     EMFQALDRDSRLSTGVRTGELAGLRLFTERVAPLVAAAQANNAFAVMAHLRATSPLLKR
                     SAIAERSTTGDPLQTIRAGVDALLGLETESPDATFLTVLQCVAQHGLFEIPAALQPFVA
                     DEPKAEIAEPEKTNEEAESKEEQAVAEMSPESLEAWRAFLETPYNQTVHFAEYVSDRGP
                     FGTHQGVKGLEFDRVLVILDDSDARGFLFSYDKLFEAKPLSDTDRKHLAEGTEGGITRT
                     RRLLYVTCTRAKKSLALVAYSEEPDTLAASALRNGWFEAHEIERL"
     gene            complement(15622..16329)
                     /locus_tag="RIdsm_RS08030"
                     /old_locus_tag="RIdsm_01613"
     CDS             complement(15622..16329)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009830025.1"
                     /locus_tag="RIdsm_RS08030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RIdsm_01613"
                     /product="IS6 family transposase"
                     /protein_id="WP_057814212.1"
                     /transl_table=11
                     /translation="MSKPNPFRYFRTSREVIRLAVMMYVRFPLSLRNVEDLLHERGIDI
                     SHESVRYWWMRFGPLFASEIRKARIQRMRCYSNHQWHLDEVFVKINGETHYMWRAVDHE
                     GEVLDAFVTKRRDRKAALKFLRKLVKRYGQPDRIVTDKLRSYGAAMKEIGNADRQRTGR
                     WLNNRIENSHLPFRRRERAMSRFRRMRSLQKFAAVHSSIHNFFNSERSLYSRQNFKRNR
                     AAALAEWRQLCVA"
     gene            complement(<16386..16847)
                     /locus_tag="RIdsm_RS08035"
                     /pseudo=""
     CDS             complement(<16386..16847)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010442732.1"
                     /locus_tag="RIdsm_RS08035"
                     /note="internal stop; incomplete; partial in the middle of
                     a contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="IS6 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MIRLAVMLNVRFPLSLRNVEDLLHERGIEISHETVRYWWNRFGPV
                     FASEIRRKRVQRLRTYSKWQ"
     gene            16752..17000
                     /locus_tag="RIdsm_RS30490"
     CDS             16752..17000
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="RIdsm_RS30490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_236553195.1"
                     /transl_table=11
                     /translation="MADLDPAFMQQVFNVPERKWEPHVEHHRQADDLLARFELFERVAF
                     CHAGRVGRRPAGLKLSCSDMAEDWLPFTLRSNEIRSE"
     misc_feature    16861..16874
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 18.34"
                     /tool="antismash"
     misc_feature    16879..16891
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 18.7"
                     /tool="antismash"
     gene            complement(17020..18531)
                     /locus_tag="RIdsm_RS08040"
                     /old_locus_tag="RIdsm_01615"
     CDS             complement(17020..18531)
                     /NRPS_PKS="Domain: Abhydrolase_1 (275-483). E-value:
                     1.5e-19. Score: 62.5. Matches aSDomain:
                     nrpspksdomains_RIdsm_RS08040_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007796388.1"
                     /locus_tag="RIdsm_RS08040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RIdsm_01615"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_057814391.1"
                     /sec_met_domain="PF00561 (E-value: 3.1e-16, bitscore: 58.1,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSQQLQISLFGELRVTRDGRPIPLPASRKARALLGFLAATGRPHR
                     RERLCELLWDVPDDPKAALRWSLTKLRKVVDTPEDIQIRADRERVWFDANNAQIDLHDI
                     TTRLKSDDVSLSVDELEHMADRLDMPLLDGLDEAGDEAFTGWLTSEREDASALRVEVLQ
                     RLATHPEMPAFKAGKWRRLWHEVDPEGASAHEEDQGATTKNAGPPPRTTRKSNPGRRAV
                     QAQRIGFCDVPDGTKIAYATIGSGPPMLKAANWLNHLEFDWNSPIWGRTFGTIARARTF
                     IRYDERGSGLSDWDVDKLEFDAFVEDLEAVADSLGLERFPLLGISQGCAVSIEYAARHP
                     ERVSGLILFGGYAAGWRHLSSPEEQARREAVLTLTEVGWGTDNPAYRHIFSQTFMPDAS
                     AEDLAWFDDFQHKTASPRNAARFQEAFGWIDVRHRLKDVRVPTIVLHSQYDQRIPLDMG
                     RALASGIPGARFVPLQSRNHIIVDKEPAWHVGIRAVADFLREHEI"
     aSDomain        complement(17083..17706)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_RIdsm_RS08040_Abhydrolase_1.1"
                     /evalue="1.50E-19"
                     /label="RIdsm_RS08040_Abhydrolase_1.1"
                     /locus_tag="RIdsm_RS08040"
                     /protein_end="483"
                     /protein_start="275"
                     /score="62.5"
                     /tool="antismash"
                     /translation="ARARTFIRYDERGSGLSDWDVDKLEFDAFVEDLEAVADSLGLERF
                     PLLGISQGCAVSIEYAARHPERVSGLILFGGYAAGWRHLSSPEEQARREAVLTLTEVGW
                     GTDNPAYRHIFSQTFMPDASAEDLAWFDDFQHKTASPRNAARFQEAFGWIDVRHRLKDV
                     RVPTIVLHSQYDQRIPLDMGRALASGIPGARFVPLQSRNHIIVDK"
     misc_feature    complement(18494..18508)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 19.28"
                     /tool="antismash"
     CDS             complement(18598..18732)
                     /gene="allorf_1758445_1758579"
                     /locus_tag="allorf_1758445_1758579"
                     /protein_id="allorf_1758445_1758579"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MISFKEQVSGCRQKALCSCLKGDRCNQSCNARIIAQSFGVSRRQ"
     CDS_motif       complement(18700..18732)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MISFKEQVSGC"
                     /locus_tag="allorf_1758445_1758579_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(18598..18699)
                     /prepeptide="core"
                     /locus_tag="allorf_1758445_1758579_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.70"
                     /molecular_weight="3626.2"
                     /monoisotopic_mass="3623.8"
                     /core_sequence="RQKALCSCLKGDRCNQSCNARIIAQSFGVSRRQ"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MISFKEQVSGC"
                     /leader_location="[18699:18732](-)"
     misc_feature    18719..18732
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.61"
                     /tool="antismash"
     gene            18925..20310
                     /locus_tag="RIdsm_RS08045"
                     /old_locus_tag="RIdsm_01616"
     CDS             18925..20310
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF014567.4"
                     /locus_tag="RIdsm_RS08045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RIdsm_01616"
                     /product="ATP-binding protein"
                     /protein_id="WP_217625287.1"
                     /transl_table=11
                     /translation="MKCQTSRIGHQLSAQWSSRRHFQKLIAQFEQTGVLDNVEARLQKN
                     DGTQFWCAVSARMLRVEEERYIYVHLLDLTDQLTARSEISRQRDALHAAEKLSAIGQLL
                     GGISHELNNPLSVLSGQALMLKEKAPTANVAARADRIINAAERCSRIVRSFLDLARNKP
                     VSPVVTNLNEVVVEAVETTIDALRGAGIDVVLELPKDLPEVLFDPDQLRQVLVNLIVNA
                     QQAMEGAGRPMRITIATRCSTDGEAVLLRFIDTGPGVPRDISSRIFDPLFTTKAPGKGT
                     GLGLALCRRIMEAQGGDIELMSTSARGTSFQLSFRSLAPVSEAGPDVRRRPATHARGVS
                     VLIVHNEEDAAADLADIVTAEGQGVEIVHSAYVAIERLRKGRYDQVFCRAGLGDLAPRD
                     FLRAVEDARPGASAGLVFLLDRTPDRKTTDYLDMVERPYLRNPIRRSDVKEVLELLTLR
                     PAA"
     gene            20327..21067
                     /locus_tag="RIdsm_RS08050"
                     /old_locus_tag="RIdsm_01617"
     CDS             20327..21067
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010438283.1"
                     /locus_tag="RIdsm_RS08050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RIdsm_01617"
                     /product="response regulator"
                     /protein_id="WP_057814208.1"
                     /transl_table=11
                     /translation="MTCGQHIAVVDDDDEIRATFEEYLTDKGFRVSSLNGGEALRALID
                     GDDHPVLVLLDITMPGEDGFSLARFLSASTNVKIIMVTASGETIDRVVGLELGADDYIA
                     KPVDLRELQARIKAVLRRSDPGTREASVQKQASRVRFGECELDLQARRLFDLDGREIRM
                     SAMECDLLRVFAERPNRVLTRDNLLELAHHGDWDPYDRSIDLRISRLRRKIERDPGKPE
                     VLKTVRGVGYVFATEATGMAEVRT"
     gene            21064..22401
                     /locus_tag="RIdsm_RS08055"
                     /old_locus_tag="RIdsm_01618"
     CDS             21064..22401
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0008519 - ammonium transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0072488 - ammonium transmembrane transport
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008561021.1"
                     /locus_tag="RIdsm_RS08055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RIdsm_01618"
                     /product="ammonium transporter"
                     /protein_id="WP_236553191.1"
                     /transl_table=11
                     /translation="MIRVMPPARLPRAGLRVCAVACTGLMLSAQPGAAEIPAETAYVLN
                     SLSFLYHGMLVFFMATGFSMLEGGLVRTKSVSTILLKNVILIAVAMIGFYLVGYNLMFY
                     NVDGGYWGTPRAWSPDQTDALSQGAAPASIWLFQTLFAVTAVSIISGTLAERMRLLPFF
                     VFVAFMSCVLYPVQGAWGWGGGWLAEMGFLDFAGGTHVHSAAGWAALTGAIVLGPRRSR
                     FADSGEVRPMAASSLPLVTLGTMILWLGWLGFNGGSQGSMDSVADVIAIANIYVNTLMA
                     TCGGIVATAALLQLLRRKIDLTMVLNGALAGLVSITAGPDTSGIVGALLIGAVGGCLML
                     WTTHLLLRLRIDDVIGAIPVHLACGIWGTLVVSLHHPEGDIRVQLIGVAAVAVFCVTAS
                     VVVWIGLRRFMRLRLSQGEEAIGIDRVETGALAYPEFATRSVLPGD"
     CDS             22498..22563
                     /gene="allorf_1762345_1762410"
                     /locus_tag="allorf_1762345_1762410"
                     /protein_id="allorf_1762345_1762410"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MRWPLTNSVGAEICTAECVSR"
     CDS_motif       22498..22530
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MRWPLTNSVGA"
                     /locus_tag="allorf_1762345_1762410_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       22531..22563
                     /prepeptide="core"
                     /locus_tag="allorf_1762345_1762410_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-4.10"
                     /molecular_weight="1074.2"
                     /monoisotopic_mass="1073.5"
                     /core_sequence="EICTAECVSR"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MRWPLTNSVGA"
                     /leader_location="[22497:22530](+)"
     gene            22697..22972
                     /locus_tag="RIdsm_RS08060"
                     /old_locus_tag="RIdsm_01619"
     CDS             22697..22972
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF018294.4"
                     /locus_tag="RIdsm_RS08060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RIdsm_01619"
                     /product="DUF1127 domain-containing protein"
                     /protein_id="WP_057814207.1"
                     /transl_table=11
                     /translation="MWSLTTNVFSLPALFGIRGSMARPAGETDTRIVAALRELSTFEDH
                     ELSDIGLCRSDLTPEGLVLAGERRKTQQAAIDREAAFSVSAVRRAN"
ORIGIN
        1 ggtcatgcga acacagatac tgtcagccga acctacgggc atctggcacc ccagatcaga
       61 gaagttcagg ttcgcacgca ttttgcagaa ttggacatga gttatgctga gaaggcgaga
      121 gggctaagcg agaaatttca ggagctttcc aaatcattgc aggggaatga ctggcgcgaa
      181 tacggaaaac ttgaacctgt tcattcatgg ccccggtcaa actttgtgac cagtgattca
      241 gaagtagcac aattactgct tggttttgag gggccagact gcgaaaaaaa gagcgaggca
      301 agtgactggc gctgagagga gatttgcaca acggcaattc tgggcgcacc ttgaaatgct
      361 tccaactcaa tttggcaact gaattgcaga tggccacttc gacgtgattt ccttccagtc
      421 cgcctcgtac ctttcatcga gttcggaggt catttctgaa ctccagagcg tgaaggcagg
      481 atttgtcgca gttgctgggt gacgggccat ggctcgccgc gaaacctttc cgggcgctag
      541 ttgaaatgag ccatgctgga tctttcgctc tagccaactc acggcatcca tggaaagcgt
      601 cggtaaaggt cgattatcca agctgactaa atccgttcca gcggccaggg atgccagtat
      661 attgggttct gtttgcccaa agtcttcata tcgccagatc atcaacttgg ctctcggcaa
      721 agctgccttt agctccgtaa ccacatccac ccacgaacgg ctcaatggcc acagggatgc
      781 agctacttcg tctttttcaa gcaaagttcc atttctgagt gcactcgtgt agttcgacga
      841 aaaaaacttc gagtaagctc ggacagcaaa gtacacgctg accgaactgt gattgaatag
      901 ctccgacaag agcgacaagc gcattgcgat atccggatac aggcccttca ggataagatt
      961 gttcttgcag gagccaatca ggttctcttc agagacaata acgcgctttg cgcgcggttt
     1021 gtcttcaact ccattacgaa tcattcgcct gagacgctgg cctgtgtccg cacaacgctg
     1081 caaatttctc gcatcggact gtctcggcga cgggagcttc agcccaattt tgcctcgtat
     1141 gtctttcggg agaaacaact gaacgcctgc ttcggaaagt ccatctcggt tcttatccag
     1201 tcgcttttga aggtatgtcg tcgcggtttt atgggcaccc aaatgcaagc agatatccag
     1261 cttatctgta tccttcgcca tcaaaatttc gatcctaaaa aaaacttgaa caggactctg
     1321 catcagccgt ctgaacttcc agcgttgcag gtcaggctct tccttgcaaa ttctcttgaa
     1381 actttggcgg cggccgaatt gctcgccagg atcctccttc catagcgcgc cggcatctcg
     1441 ggcgacgtcc agcgaccggc caccatgatg gaagagaggt cacaaccaat ccgaaaggcg
     1501 tcatgaacgc ctcccacgcg tgtactgtgg gccgatacat cctttcggcc ggtgcatcgc
     1561 ttgatgatcc ttgaaatcgt tgccggatcc atcggggcaa tgcgtgcgtt cgcttgggac
     1621 ttggtcagca gcggatcctc ggatttcaat ccggccagtt cgatccattc aaggactgcg
     1681 gccgttccct gctccgatag aaaggcgtag gcgccttggc cgaattggtc cgtctttgac
     1741 ttcgcaacga agaggagact tgaaccatcg tcctgccgga tcaggtcgcg aaccttgaag
     1801 gcgacgattt ccgaagaccg gcaccagcta tcggtcgcaa cccacaggac agctttgtct
     1861 ctgatatgtt gtcgagagtt cccgagcttc tggatcgcct tgtagacttc cgccttgcaa
     1921 agcggtggtg cttgccgaac ccatgcaccg tacttccgct tcacgccttt caaagccaac
     1981 tccacgagcc tgtgccggca tggtgtcggc tgaaaggtgg ctcgatgcat ttcggatatt
     2041 gcccaaagcc gggtttcgat ggtcgtgcat ttaactttgc cacccagata gtcgacatac
     2101 tcggcaaccg ctcttggatc gacgggtggg tccgggttgt gaccatgctc agaacaccaa
     2161 tccctgaagt tctgggtgat ctggcggtag ttacgaagcg tttccttcgc aaaggcggcc
     2221 tctgagcgct tccggtactc agcgatgagt gcttctcgtg tttcggatgg tgcatgggcg
     2281 agctttacga ctgtctccag acgttcggcg tcccggtcaa aattgtaatc catctgagcc
     2341 tcggcttgtt cgattagaaa tccgtatgtt cagacaagcc ggtattaacg attcgttaag
     2401 ctttttaggt gaaggcttcg ggcatgagag agccaaaaaa ttcccaagtc tcagaccgtt
     2461 tgatcatggc agaagaggtc atagcggagt acgtccagaa gttcggcttt accgttgcag
     2521 cgaaatgcta cttcctcagt tggaatgacg aagagaacca aagtgatacg cttggagccg
     2581 atgttttacc gccagatacg gtaggtggac agcgaccaac tctggataaa taaagaaaat
     2641 cccttccttc attcacgttt tggttgtgcc acatttgaat ctccgaaaag gtggtggttc
     2701 aaaaataatg agggacagat gagacttcgt aatcttacca ctattttcgt agctgtgtgt
     2761 gcattggccg cgtgtgactc ttactcggca caacaatacc aaagcagtcc tcagaacgtg
     2821 attgcgcttc agtcattggc gaaacaaggc gttcgtgctt cggtgggcac cgtgcaggtt
     2881 gctgaaggcg ttaatgcaca gccgacctgc cgtctggctg gtccattgga tctggggggc
     2941 ggacaaagcg taaccgagac cgtcaaagaa gcaattcagt cagagttcct agcttcgaac
     3001 atttacagcc caagcggaac gcctattagc gtcgttatta cacaactcaa accgagttcg
     3061 ttcgagggga cttggacgat ttcgatgcag gtttcatcac agcgaggcaa aggttattca
     3121 gtcacgacca acacgaagtt cagcactagc ttttctgcta tggcggcatg caacaatact
     3181 gcgcaagcat tcaacagagc cctgagtgcc gcaatcaacg atatggtcac cgatccaagg
     3241 ttccgttcac tgctatagtc atctgtttgc gctcagattg ggaaaccccg aaatgagcgg
     3301 ggtgaatagg tagctgtcag tttcggccag tttcggctgg ccgcggcatc gcctaaaggc
     3361 cctggtcgga cattctgaat ttcagggcgg tgttcatcaa cgctcgccgc cgtctacgta
     3421 ccggccagtt acggtgtgat cttctgacgg tacatcctct caagctagat ctttggggct
     3481 cgatcaaggg cgcgcggaac ggtgccgcgc ccttttctgt gaacaggcgt gcaattttgg
     3541 cctcttagca gggtgatcgg cgtcgaaaaa tggctctgaa tcaatttcgg tgcagcttgg
     3601 ggccctccgg tcaggatacc tcaacgagcc gggctctgag caggtcgatg ttggcctggc
     3661 catacatctg gcgtttgagg gtcttgaggc ggttgatctg tccctcggtc tgcccgttcg
     3721 accatggctc ccgcagagca gcggcgaccg cggcctggtc ccgccgaagc ccgcggggtc
     3781 cggccgaagc ccgcgggcga aagcaccgag ctggctctct ccggctttgt ccaaccatgt
     3841 ttccaatgct gttggatgtc actgagaact gacccggcgg cagtcaaaat tgtcactgaa
     3901 aattgacccg tgtggaacca tgcccttgac gggatttgtc gggggttttc ggagtgatcg
     3961 acatgggttt attgagcgtc attcgacgtt gggcattgcg ggacaagatg cccatccgcg
     4021 agattgcgcg gcggacaggg ctgtctcgca acaccatcaa gaagtatttg cgagcgggga
     4081 ttgttgaacc ctagttccag aaaccggcgc ggccaagcaa gctggaccca tatgctgaga
     4141 agctgacagg ctggctggtg accgagcagc gcaagtcgcg caaggaccgg cgcactgcca
     4201 agcagatgca cgctgaccta gttcagcttg gctatgacgg ctcgtttgag cgggtcgcag
     4261 tcttcgtgcg gacctggaaa ggagaccggc aacgcgcgca tctgacgacg gatcgcggga
     4321 cattcgtgcc gctggtgttt cagccgggcg aggcgttcca gttcgattgg agcgaggact
     4381 gggcccatga acctgaaaca cgctcttcgc gagatcgaga ccgagaatcg aaatatcctg
     4441 atgcattcga tggctcctta ggcctggctt aacggccaaa tcattgcaca ctacgccggt
     4501 gcaggggccg tccacagcat caggtcagaa ttttaacagg tccagggagc gggcaggtcc
     4561 gtcgcaagct catgcgtatg acactgccct ctgccgctta catcatagac atcattggca
     4621 gacaaggagg ccgatcaaat gctcatagga tacgcacgtg caagttaacc tagcatgccc
     4681 cctttgacag tgtcttggaa ctgatcaatg attgggtctg cagcacgttg cgtgctggca
     4741 aaccttgtga gattacaacg aagaccagtt atgactttaa atgataccaa gaagatttcc
     4801 cgacccaatg ctgttacgcg gagcttgctc gcactcctta tcggggccgt cggtgccgca
     4861 gtacatactg cgatcgtgtc cacaattcct gtgttgatca tgattgtgag cacgttttcc
     4921 attgctctgg cggctttgag ctgcgtgttc tacgcgatga tcccgagctc cgggttcaat
     4981 cgcttctgga ttgccgctat cggcggctgc gtgaacgtga tcgtggcggt gcttgtctgg
     5041 ttcgccatcc gtctgggcag cctatccgac gcgtttttcg tgctcagcat gggccccggg
     5101 gaagtctgga gcacaatcgt tctcttttcc cgaaacatcg cattttccct gaacgggtcg
     5161 gagttgacag gcgagagcct gctttacatc ttctgggttc cggaactggt gctgctcttc
     5221 ctgtttcccg tcatcatgtc gcggttcggg agcgggctga gtggattgcg ctgatctcaa
     5281 aagtggtttt gcggcctgtt caggaaccgg catatgtgag cgcgtgcgaa tgcttctgat
     5341 gcgcgcgtgc cgctgactgg tcgcctcggg tcaggcagca acgtcttctt cgaccttgac
     5401 cgtttgaccc agcttttcga accgggacgc gaggtaatag gccattgcct ggcttcgcag
     5461 gtccgaaatt cggattgccg cttcctcgcg cagcacgaag ggaaggtcgg gaaccgcgcc
     5521 ggcctcgtcg cctgtcgcga tttcgaccgt aatgcaaaac ctttcggcgg cgcctgccaa
     5581 gtgcattcgc aattcgttca gcatcgcgac ctcggccttt gaaatctggt catcgagact
     5641 ggcgacgaga ttgacgagac cgaacacgaa ctcacaaagg ccgtactccc cgtcagctct
     5701 ggtcaactcg cgaaacacct gtatgagccg gagtgaatgc tggatcgacc ccatcgaaag
     5761 gtcgagtgtg ttcagcggga tatcgagaaa accggccata tgtgtcagaa agttgtgttc
     5821 ccgcttgtcg atatcctcgt cgatggccac ggtatgggcc atgacctcga gcaaccgtgt
     5881 acgctgcacg tctggtaacg agagcgcatg cgacttgcga agcgtgcctt ccatgacaaa
     5941 caggtttacc aggttcatgt cagactggca caggtaggtg acgacatccc gatcgagcga
     6001 gatcagggtg ctgtcttctg ctgcctcggc gccgttctcc gaaagcgcgt attcatcggt
     6061 ccacaggccg aagacctcgc ccggcccccg gtccaccaca tggcccgcct tggtataggt
     6121 cacgcgcccc gtcaccacaa aaagaagcct gtcgatatcc gacctgggag ggaacacagg
     6181 ctctccctgc cggaagacct cgaaactgcc gagctcccgg atggccgcat acatgtcgta
     6241 cggaatggcc ttgaagaggg cgtgcgcgga aagataggcg tccagattca ggtcatgatg
     6301 ttcgatcatc gtgctacgct ttcgttgacc ttctcggtga ccttggcctt ttccagaagc
     6361 aatgtgcgat cagagcgtct accgacgaac tgatcatgag tgatcgtcag gatgatcgct
     6421 ttccgcttca ggtcgtggag catcgccacg atgcggttgc gcgcctgttc gtcgagcgct
     6481 gatgtgggct cgtccatcac gtacaagtcg ctctcgcagg caaggcatcg acagattgcg
     6541 accaactgac gttgtccgcc ggaaagtcgc tgtccccctt tcccgatgcc ggcgccgagg
     6601 gaccagtgaa gcaggtcgtt gcgtgcgaaa cgtgtttcga ggacatcgag gatcatctga
     6661 tcgatcgtat cctcgatacg cttgtttcgt acgacaaccc gccccgcgat caggttgtcg
     6721 cgcagcgaca ggttaatatc cattaggtct ggatcgcccg tgtcgcggga aaggttccgc
     6781 tgcctgatcc atccgataag atactcgcgg ctctcggcat caagcacctg ttcgaggggc
     6841 acgccaggga actcgtcaac gcgtgccgac aatgccgagg cgatcagcaa gagcgcctgg
     6901 tcctcgctct cttcgatcct gaccagcccc atcgccgccc gccgcaatgc ccagacgtgt
     6961 tcgtccagga tgttattcgt caggcggaca tagatgtcgt gactgtcgag attgcgaagg
     7021 ctccaatccc accgctcaag aatgtgctgg ccaaggcgac gcagcgccgg ccagtcgtgg
     7081 ggcgcctcct ggcccaaggc cacgaggcgg tcgagcgtca gatccgcatg gtcgatatgc
     7141 agccccgtca gcttttcgat cagaagaacc gcaccgtcat tgcgctttga cgggaccagg
     7201 tgcaggccct tcatggcagc aagatgcgta gcaagctcgg cgcgcagctc cgatatgttc
     7261 ccggagttga ccggccagtc atcatttggc ggctgatcga ggatgttctg gaaacagaat
     7321 tgagccacgc cggatttttg aacggcctgc agcatcattt cttcgtcaag ctcgccctcg
     7381 ggaacggcga tctcgatgtt gtcacgcaca ttcccgctaa cgagattgac ctgctgcggc
     7441 atgtaggaaa tcctgatgcg gtccagcgcc gcccccgatt tgtcgcgccc ggttatggtg
     7501 cccttgtcct gcggcatgcg cccaagcaga agattgatca gggtcgactt cccgctgcct
     7561 gaaggcccca tcagagtgta ccagcgtccc tgttcaaggt cgaaagatgc atccgccacg
     7621 atcggcttgt cgtacccgaa cccgaggtct ctgacctcga gccgggtgcc ggaaactcca
     7681 tccggcatag cagcctcttc ggattccggg ccattttcct cttgcgaagc atattcgcca
     7741 agccgttcga cgctgttgcc gcccagttgc agcagcgcgc gcgcctgaat gatcgcggac
     7801 aatccggaaa acagctcggg cagaaccttg atgaccaccg gaatgagcgc gatctgtgtc
     7861 gcgtcgtcgc caactcccca gagcagcgcg acaacaatca ttgcaagcga cagcacgtaa
     7921 gacagcgtgt tccacgacac cagtgtctgg tggtgcagga agaagcgcag gtatgtccgg
     7981 tcacgcttcg cctgatgggc gctcaggcgg cggaacatgt tgggagcgat gcgaaccacc
     8041 tgcgcaattc cgcgcagtcc caggttgtcg atcacgattt ccttgccgcc atcctcaagc
     8101 acggcgaact tctggtcgat gcttggcagg ggctttgcaa gctgaacgct gatcagtgca
     8161 cagaggacca tcgccccgaa tgtcgccgcg gcgacaagca cgtcgaccga caggaagaaa
     8221 aggaaagtgg acaacaggag aagcacctga aagatcaggt ccacaaggtg atcgcgccgt
     8281 tcgcagaccc gccttatgtc aaagaccatt cggttgccga tttcacccaa cgaggtgttc
     8341 tgaaaaaagc catcatcctt gcgaagcaga ttggcgaaga ccgcggcctc cagatcgctc
     8401 ttcgaccgcg tgttcatctg tgtctgcagg atgtgaccgg cgcccgaggc agcaatcttc
     8461 agcaggctca cgaccacgaa aaggatgaga aaccccgccc acggctgaac ggcctggtgt
     8521 tgcaccgcag tccggattgc tcccatcaga cctccttgat cgtcgggcct gtcgtccgac
     8581 aggctctgga tcatcaacag caatgccgtg ttctccaggt acacaagccc cgcggcaagc
     8641 aggccgaagg cgataacgat caggaacttt cttagatacg gtgccgcaaa gatgggcatc
     8701 agtcgcgaga tttcgaagtt ggattgcatt cggctttccg atcgagtttt caccaccgct
     8761 tcattcaatg tggagttcga ccgttatggc tcccattaaa aatgtagact caaatcgact
     8821 gccatgttac ctatattaca cgtcttttaa agtgggtaac ttaacttatc ttattataaa
     8881 gactaaatta ttagagaagg accttagtac ggtaatggaa agcaagattt ttgaatcccg
     8941 cgaacaagat catcatttct cctccaaaac ctcggatgtg gtgacaaccg aaaccgccat
     9001 cgcaaacacg agcggtcagg cgccgcgtgc gatggggact ggcttctcca cttgtccggc
     9061 caagacggga aagtactgct gaagcaggcg gcttttgtcg gcttttctct gccgaaagct
     9121 catcgggatg ccgggccccg gcatcctctt tcaccgagag cctcatgcac accgaaacgg
     9181 gttgcgaaaa ggatctgcgc cgcgtccgtc agttcgacgg cgtacctgat ctcgcctgtt
     9241 tcacggagca gcttcactat aacctcgaac cggttgtcct tcgaaattcg tgcttcgact
     9301 ggcagccggt gcgcgagtgg agccctgaac gactggaagg caagctggcc gaccagatgc
     9361 tacgcatttc ctcttccgct tcggggtact ttccggacac agggtcaacc tgtcgtgaaa
     9421 aactgtcggg ccgagccttt tttgagcgct tgaaggacga ggccgccgga cgttcgcctc
     9481 gatacagcta tctcgacgga tcggagacgt tcttcaacct tggaggcgaa agctcttccg
     9541 cgctagtggc gcttgaaccg gaagcccgtc cgccccgcgc ggtactgtcg ccctttctgg
     9601 tcaaatcggc gttatggatc gggggcggcg gcgtccattc aggcctgcat tacgatggca
     9661 acggatgcaa caatttcaac gtgcaggtct gcggccggaa atccataatt ctgctttcgc
     9721 cgaaatatat cgaccgtctc agcatgcttt caccggacaa attcgcgcat ctgggacatt
     9781 ttagcgggct gagtctggat cgtgacgaca tggcaggcca ccctgcgttc tcggagctca
     9841 ccctgtatca tgcggtgctc gaccccggtg atgtcctttt cattcccgcg ctctggtttc
     9901 atgcggtcac atcgcttgaa gcattcaatg cgaacgtgaa tttctggacc ttgcccgatt
     9961 ccacctatct gacgccgctc ctgaaagatc tggtcacctg atgttaagcc gggcgcaaat
    10021 gcaatccatt gcggccggag cactctcgct ggaggaaaga tgggcgtttc cagggtcaac
    10081 ccggcgtccg tgcgatgccg aaacgcttgc gaactggtac gaggccctga atggggccat
    10141 gcctcaacgg ttgcatctgg ccggccagga aggaaccgat ccggccgacc tgctcttcga
    10201 aatcgatcct gccggtatcg acccgttgcc ggcttgggtc gtggcgttga actcggcgct
    10261 gtgcgatctg gggtcatctg cggaacggcg ggttgttgcc cccccgggaa gcccttcgct
    10321 ttccccggag cctttcgaag aattgctctg gccattggcc cgaacgctgg ccgacgattg
    10381 gacagcggag cagaagaggc ttctttctga agtggcgcgg tttcaggcgc gtcatgcctt
    10441 gctgcggcgg ctggcccgcc aaaccgaacg gtcactgggg gttgtctttg caaactaccg
    10501 tgcatcgcac acggaagccg gcgcatacgg gcgtttcatc gcgttaatgc ggcaaggcgg
    10561 atttggccaa tatctccttg cctaccccgt ggccgcccgc gcgatcatgc gcactgtcga
    10621 caactggcat tccgccttgc aggaaatgat cgaacgcctg gccagggatc aatcggccct
    10681 taagagactg acgggaacat cggcgatctt ccccatccgg gacatcgatt tcgaactttc
    10741 cgatccacat gacggcgagc gtagcgtggc gcgtcttaca ctggctgcgg gaaaatccgt
    10801 ccactacaag cctcggccca tcgaggcgga gcatgtgctg gccagtgtcg cccgaaagtt
    10861 cgaagacttc gacccggcgc gcttctcact gccatgtccg gcaatgattg cacgcccaga
    10921 ctgtggatgg gttgaaacga taacgcagac cgacctgccg gaagacgtgc ctccatcctt
    10981 gtatttcaga cgcttcggcc actggctcgg gctgatgcat gtcctgcaag gtggcgacat
    11041 ccatcccgat aacgtggtcg catgtggtgc ccatccccat atcgtcgacg ctgaagttct
    11101 gttgcagggt gttctgtcgg aaaacaattt ttttatcgac gcagcgagag acccggcgct
    11161 gcgcgcgctg tcgtattcga ccattcatac cgggatgctg ccgagtttcg ccgtgaagga
    11221 ggatggacaa actacggacc agagcggctg gtatcttccg caggccaatg acttgaacag
    11281 gctgcgccaa cgctgggccg aaatcaactc ggacgatatg catttggcgg atgaaaccgg
    11341 gccgcgggcg acacaccacc ttccgaccat aggcggtcgg caggtcggtg cgcgtgaaca
    11401 cgccgccgat atcgttgtcg gcctgcgcga aatattggaa gcctcgctcg acttgcgcga
    11461 ccccgttgct gttgaactgg acaggctgat ggcatccggc acgatcgcga caaggttcgt
    11521 ttttcgcgat actcaggtct atggcgcgat gctggatcgc ttggcggacc caccagcaca
    11581 acggtcggga ctggcgcgaa gcataaggct ggaaacgctt gcccgcgtgc tgaaatcccc
    11641 gaaaacaggc tcggtcgtgc ctgctctctt gcgttcagaa ctgaccgccc tcgagcgcgg
    11701 agacgttccg ctctttcgta ccttcgtcgc gtccggtgag atcctgtccc ggcgtcaggt
    11761 catcgtgacg aacgcatttg gcccaaccgg tgtgcagtgg gtgaagaccc gtttggctgc
    11821 attggctccc gcgagcattg cacgagaggc cgacatcgtt tcaagcgctt acatggccac
    11881 acatgacaag tcaccggccc caccaagaga cagcggtggt tccgccaact tccgtgaatt
    11941 ggccgtgccg gaaatggaac ggcttaccac gctgctttcg agaacggctt tgcaggatga
    12001 tggtgacgcc ctgaactggc ttgcgattca gccggtcggg actgaagggc ggacccacgt
    12061 cgcgccgctt gatacatcac tttacgatgg tcttgccggc atcgccctgg cgcttgccgt
    12121 ttcggctgac gtgacccgat ctcgaatggc tgcaacgctg tgcgagggta gcctgaagac
    12181 cattgcgcac aagctttcag ccggcgacct ggccgaggtg ggcccgggat atggtgaagg
    12241 tgtgggaggt gtccttgccg cgtcggccca gatcgcgagc ctgtttccga acatgatcgc
    12301 acggcaggtg atcgaccaga tcgccacggc gctcgaaaga gggcaggaac tggaaacttg
    12361 ggacgtcgag gacctgtatg gaggaatcgc cggcctgatc ctcggcctcg gagcggtgga
    12421 gcccgtgctg ggaagggccc gcaccgcggt gttgatgaaa cgggcattta aacgattgaa
    12481 gctcctgctg gctcgtccgc aatccgacac aaccggccgg gcttggggtt ccggcatggc
    12541 ccatggcgcg ggcggcatcg ccgcggcgca agccatgttg cagtcattcg gggtgctcgg
    12601 gccgcacgaa aacctgcccg agagcggcga aagcggcgct ccggcgagta cagatgatga
    12661 aaaaccggca cgagcaacct cctggtgtca tggtgcaggg gggctggctc tcgatacaag
    12721 catccttcaa agggcggccg gctgcggccc cgatcacctg tgttgcggcg aagccgggcg
    12781 attggattca aggctggccc ttggagatga tgtcgaaccc cttcgtcgtg aggcggcggg
    12841 catggtgtca gcggcgcaag gttccgtcgg gtatcgattc tatcttcggg gccccgacac
    12901 actgaaaccg ggcctcttca ccgggcatgc cgggatcatc tacctgttgg cgcgattgca
    12961 tgacccggat cgatatgact caatcctgcc gcggatgacg ttgaccaggg ccccgcgacc
    13021 gaaaaaggaa attgcatgaa ggatttcaac aagccgacac tggctgatct gttgggtgac
    13081 atgacggcag atacgtttcg gacaaactac aacaacgcgc gcacggtcca tcttcccggc
    13141 gcaatgagcg atcaacggca tcacctcgat ttctccgagc ttcgcgcttt ggtcgaaaac
    13201 ctcgacaacg ctgcggaata ctggcttgac gaggccgggg tcgagcgcag cgtcagtctg
    13261 gacggcaaga ccgcatggca gcgcgcgcaa gagggttgca ccctgatatg caacggtctc
    13321 agccgggtca gcgaaccggc aagggcactc tccgagagca tgatcgatgg actggacggc
    13381 gagggctggc ccggggcgcg gctgttttac tcgaccgcgt tcgattacgg ctatgcaagc
    13441 catcttgacc ctttcgcgac cttcacggtt caggtttccg gccgaaaacg ctggttcgcc
    13501 tccccgacgc ccgagcggtt cgatgtacag aaactctccc attcggtcat catgccggcg
    13561 ccgggtgaga tcgaagaaat gccgttcttt accttccggc accgggagga aacggatatg
    13621 cagagtttcg atctgatgcc aggtgacgtg ctctatttcc ctgccggaac atggcaccgt
    13681 gccgtttcgc tggaaccttc gctttccgtg gccatcgata ttcgtccgcg tattctgcct
    13741 gaaccggaat tcgaggcaac ggttatccgg catcccccac ctgactgagc ctgtgagagg
    13801 gtcctgtcac acggtttcga actcgtcttc gctaatcggg ttgcatttgt gaagtccttc
    13861 aagcggtttt ctcgccttgg tatttgtgcc ccggctggtt cgcggtattc gaaaatactg
    13921 aagatgacga gcgataccct gaaacgaatg gcaggaatgt atgcattgca gacattgctg
    13981 agtagataaa agtaagtctg gttcggggca aatgcggagg cgcgtaggtt ccattatgtt
    14041 aacgttctgt tcgcgccctt cgccgccgag ctagatgggc gggaagctga ctttcgctgc
    14101 tctaccgcga gaaattgcac agatcgggaa agcggacgtt cgaccccacg aaccagggtt
    14161 ggtcattttt cgagacagtt cttcagggaa gctggcattc gcagcagcaa gcgcaaatgg
    14221 tcggcttgca gtcgatcgcg aacccagggt gctttcgctg ggtgctgcat ggatcgtcac
    14281 atcatcgatc aaaattctgc gaaaaccgtg gtcaaagtcg ctcgatctca tgagcttcga
    14341 accagccgtt acgaagtgca gaagctgcaa gagtatcggg ctcttcggaa taggcgacca
    14401 gcgccaagct tttctttgct cgtgtacaag tgacgtaaag caggcggcgc gtgcgcgtaa
    14461 tgccgccttc agtgccttcg gcaagatgct tgcggtcagt gtccgacagc ggcttggctt
    14521 cgaatagctt atcgtaagaa aacaggaagc ctcgcgcgtc gctgtcgtca agaattacca
    14581 gcacacgatc gaactcaagc ccttttacgc cctgatgggt tccgaatgga ccacgatcac
    14641 tgacatattc ggcgaaatgg accgtttggt tgtacggagt ctcaagaaat gcccgccaag
    14701 cctctaggct ttcgggagac atctccgcaa ctgcttgctc ctctttcgac tctgcttctt
    14761 catttgtctt ctcaggctcc gcaatttcag ccttcggctc atcagctaca aacggctgca
    14821 aggcagcagg aatctcgaac agcccgtgtt gcgccacgca ttggagaacg gtgagaaagg
    14881 ttgcatctgg gctttcagtt tcgaggccca gcagcgcgtc tactcctgca cgtattgtct
    14941 gcaagggatc gccggttgtt gacctctcag caattgctga tcgcttaaga aggggagaag
    15001 tcgcgcgtag gtgcgccatg accgcgaaag cattgttcgc ctgtgcagcc gcgactagtg
    15061 gagcgacgcg ttcagtaaag agccttaggc ctgcaagttc tcccgtccga accccggtag
    15121 ataggcgcga gtcccggtca agcgcctgga acatctcaag gaacccgtac cttgaagccg
    15181 ccatatggtg ttcaagcgtg agtgccttaa ctccagcttg gtctcgccaa ttaggatcgt
    15241 tgcagaattc agccattcga tcctgaacct gccgttcaag cgctggcttg tcgggcgagc
    15301 tgctagaggc aacaaacaag cgaacgaggc cgacatcgct atcgtcgcgg gccacctggc
    15361 tttggcgatc aattggagcg cgaagtacat tgccaagcgc gatcacgcgt tgaggcgatc
    15421 ggtgattcat tctcttcacg ggacgcgccc aatcatccgg aacgaggcgc tccagttccg
    15481 gatggccgtc aagaaagatc cgctgcatca tatccccgaa caggcccacc gcaaacttgt
    15541 ccttgttcgc cgcagcaagt gcgaagaagg ttctgtcaga cggattcgaa ctcgtctcgc
    15601 cttggacagt aacgctgccc tttatgcgac gcagagttga cgccactcgg cgagagcagc
    15661 ggctcggttc cgtttgaaat tctgtctgct gtagaggctt cgctccgaat tgaagaagtt
    15721 gtggattgaa gagtgaacgg cggcaaattt ctgtagactt cgcatgcgcc ggaagcggga
    15781 catggcacgc tctcgtcgtc ggaatggcag gtgtgaattt tctattcggt tgttcagcca
    15841 gcgccctgta cgctgccgat ccgcgttccc gatttccttc attgccgcac cataggaacg
    15901 cagcttgtcg gtgacgatgc ggtctggctg cccatagcgc ttcaccaatt tcctgaggaa
    15961 tttcaatgcc gctttacgat cgcgacgctt tgtgacaaag gcatcgagaa cctcgccttc
    16021 gtggtcgacg gcccgccaca tgtaatgggt ttcgccgttg atcttcacga agacctcgtc
    16081 cagatgccac tggtggttgg agtagcagcg catccgttgg atcctggcct tgcgtatctc
    16141 cgaggcgaaa agcgggccga accgcatcca ccaataccgg acggactcgt ggctgatgtc
    16201 gatacctcgc tcgtggagca ggtcctcgac attgcgcagt gagagcggga aacgcacata
    16261 catcatcacc gccaagcgga ttacttcacg gctcgttcga aagtagcgga acggattggg
    16321 tttgctcatt gaggcagggt agaggccagc gaggtcgctc gcaagctcat ccctctgaca
    16381 ctgccggcgc gattgttgag ccagcgaccg caggcttgca gatcgccaca gccaagttct
    16441 cgcagcgcgg cgcgatacga gggtaggcgg tcggtgacca ggacttctgg ctttccgtat
    16501 cgccgcatca aattcctgag cattttgaat gcggcgcgct tgtttcgtct tttcgtgacg
    16561 acgctttcca gcacctcgcc ttcatggtcc aaggcccgcc agaggtagtg gcgctcgccg
    16621 ttgatcttca cgaacacctc gtccccatgt cactgccact tcgagtaggt acgcaggcgt
    16681 tgcacgcgct ttcggcgaat ttctgacgcg aacaccggtc cgaaccggtt ccaccaatac
    16741 cgaacggttt catggctgat ctcgatcccg cgttcatgca acaggtcttc aacgttcctg
    16801 agcgaaagtg ggaaccgcac gttgagcatc accgccaggc ggatgatctc ttggctcgat
    16861 ttgaattatt tgaaagggtc gcgttttgcc atgccggcag ggtagggcgc cgaccagccg
    16921 gcctcaagct gagttgttct gacatggccg aggattggct acctttcaca ttgcggtcaa
    16981 acgaaattcg cagtgagtga tatattgcgg atgtttctgt cagatctcgt gttcccgaag
    17041 gaagtcggcg actgccctga tgcccacatg ccaagccggt tccttgtcga cgatgatatg
    17101 gttgcggctc tggagaggga cgaaacgggc gccgggaatg cccgaggcca gcgcgcgccc
    17161 catatccagt ggtatccgct ggtcgtactg ggaatgcagc acgattgtcg gcacccgcac
    17221 gtccttgagg cggtggcgca catcgatcca gccgaacgcc tcctgaaaac gtgcggcgtt
    17281 ccttggcgac gccgtcttgt gctggaaatc gtcgaaccat gccaggtcct ctgcgctggc
    17341 atcgggcatg aaggtctgcg agaagatgtg ccggtaggcc gggttgtccg ttccccagcc
    17401 cacttcggtc agggtcagca cggcctcgcg ccgcgcctgt tcttcggggc tggagaggtg
    17461 gcgccagccc gcagcatagc cgccgaacag gatcaggccg ctcacccttt ccgggtgtcg
    17521 cgccgcgtat tcgatcgaca cggcgcagcc ctgggagata ccgagcaacg ggaacctttc
    17581 aagtcccagg ctgtcggcga cagcctccag gtcttcgacg aaggcatcga actccaattt
    17641 gtccacgtcc cagtcggaca agccgctgcc gcgctcgtca taccggatga aagtgcgagc
    17701 ccgggcgatt gtgccgaacg tcctgcccca gatcgggctg ttccaatcga attcgagatg
    17761 gttcagccag tttgccgcct tcagcatggg tgggcccgag ccgatggtgg cataggcaat
    17821 cttggtgccg tcgggcacgt cgcaaaaccc gatacgctga gcctgtacag cccgtcgacc
    17881 gggatttgat ttccgcgtgg tccggggcgg cggtccggcg ttttttgtag ttgcgccctg
    17941 gtcttcttca tgggcgctcg cgccctcggg atcgacctcg tgccacaggc ggcgccactt
    18001 ccccgctttg aacgcgggca tctcgggatg ggttgcgagg cgctgcagga cctcgacccg
    18061 cagggcgctg gcgtcttccc gttccgaggt cagccagccg gtaaacgcct cgtcgcccgc
    18121 ctcgtcgaga ccgtcgagaa gcggcatgtc aaggcgatct gccatgtgtt caagttcgtc
    18181 gaccgaaagg cttacatcgt cggattttag acgcgtcgtg atatcgtgca ggtcgatctg
    18241 ggcgttgttc gcatcgaacc acacacgttc cctatcggcc ctgatctgaa tgtcttcggg
    18301 ggtgtcgacc accttgcgca gtttggtcag ggaccagcgc agggccgcct tggggtcgtc
    18361 cggtacatcc cagagcagtt cgcacaagcg ttcccgcctg tgggggcgcc cggtcgccgc
    18421 caggaagcca agcaaggccc ttgccttgcg tgaggccggc aagggtattg gccgaccgtc
    18481 ccgagtgacc cgcaattctc cgaacaatga aatttgcagt tgctgcgaca aggcctgttc
    18541 ctttttgttc gaacaaccca accagacgtt ccggtctggg caaccctttt ctaatcgcta
    18601 ctgacggcgc gagacaccaa aagattgggc gataatacgg gcattacaac tctggttaca
    18661 acggtcaccc tttaggcagc tgcacagagc cttttggcga cacccggaaa cctgttcttt
    18721 gaatgagatc aacagatcag aagagccatg cccgtgactg ctttggaatc gccccgaaaa
    18781 agccgtataa gtcctttcgt aggctacgtt atatcttcgt acgagattgc cgaagaattg
    18841 gtgcggaact gtccgtcggc ggtgatcgtc gcgcgtcttt cggacggccg aatcgccgcc
    18901 gaaagcgagt tggcccgaaa gctgatgaaa tgtcagacct cccgcattgg gcatcagctg
    18961 agcgcgcaat ggtccagccg ccgccatttc cagaagttga ttgcgcagtt cgaacaaacg
    19021 ggggttctgg acaacgtcga ggcgcggctt cagaagaacg acggaacaca gttctggtgt
    19081 gccgtttccg cccgaatgct gagggtcgag gaggagcggt acatctatgt tcaccttctt
    19141 gacctgaccg accagttgac agcgcgaagc gagatttccc gccagcggga tgcgcttcac
    19201 gcggccgaaa agctcagcgc gatcggccag ctacttggcg gcatctcgca cgagttgaac
    19261 aatccgctct cggtcctgtc cggtcaggcg ctgatgctga aggaaaaggc gccgaccgcc
    19321 aatgtcgccg cacgggccga ccggatcatc aacgccgccg agcgctgctc gcgcatcgtg
    19381 cgaagctttc tcgatttggc ccggaacaag cccgtttcgc ccgtggtgac caacctgaac
    19441 gaggtcgtgg ttgaggcggt cgagacgacg atcgacgctc ttcggggcgc gggcatcgac
    19501 gtcgtgctgg agttgcccaa ggacctgccc gaggtgctgt ttgatccgga tcagctgagg
    19561 caggttctcg tgaacctcat cgtaaatgcg caacaggcga tggagggggc cggtcggccg
    19621 atgcgcatca ccatcgccac acgctgttct acggatggag aagcggttct gctgcggttc
    19681 atcgataccg gtcccggcgt gcccagggac atcagttcgc gtatcttcga cccgctcttc
    19741 acgaccaagg cgccgggcaa gggaaccggc ctaggcctgg cgctgtgtcg gcggatcatg
    19801 gaggcgcaag gcggcgatat cgaattgatg agcacctcag cccgcggcac gtccttccaa
    19861 ctgtcgttca ggtccctcgc gccggtttca gaggctggcc ccgacgtccg ccggcgtccg
    19921 gcgacccatg ccaggggcgt ttcggtcctg atcgtccaca atgaagagga cgccgctgcg
    19981 gatcttgcgg atatcgtcac ggccgaaggc caaggggtcg agatcgtgca ctccgcctac
    20041 gtggcgatag agcgattgcg taagggtcgc tacgatcagg tgttttgtcg ggccggcctc
    20101 ggtgacttgg ccccgcgcga ttttctgcgg gccgtggagg atgcccggcc cggcgcctct
    20161 gccgggcttg tgtttctgct ggaccggacg cccgaccgca agaccacgga ttacctcgac
    20221 atggtcgagc gcccctatct tcgaaacccg atccgccgca gcgatgtcaa ggaagtgctc
    20281 gagcttctga ccctgcgtcc ggcagcctga ccagaggagt gacttcatga cctgcggcca
    20341 acatatcgcg gtggtggacg atgacgacga gatccgcgcc acctttgagg aatacctcac
    20401 cgacaagggg ttccgcgtgt cctcgctcaa tggcggtgag gccttgcggg cgcttatcga
    20461 cggtgacgac caccccgtcc tggtccttct ggacatcacg atgcccggcg aggacggatt
    20521 ctcccttgcc cggttcctgt cggcgtccac gaacgtgaag atcatcatgg tcacggcgtc
    20581 gggcgaaacg atcgaccggg tcgtgggcct tgagctgggc gcggatgact acatcgccaa
    20641 acccgtcgac ctgcgggaat tgcaggcccg catcaaggcg gtgctgcgcc gctctgaccc
    20701 cgggacgcgc gaggcgtcgg tacagaaaca ggcttcgcgg gtgcgcttcg gggaatgcga
    20761 gcttgatctg caggcccggc ggctgttcga cctcgatggc cgtgaaatca ggatgagcgc
    20821 aatggaatgc gacctgctgc gggtgttcgc ggagcggccc aaccgggtgc tgacccgcga
    20881 caaccttctg gaactcgccc atcacggcga ctgggacccc tacgatcgtt cgatcgacct
    20941 gcggatctcg cggttgcgcc gcaagatcga acgtgacccg ggcaagcccg aagtactgaa
    21001 gaccgtgcgg ggtgtcggct atgtgttcgc gaccgaggca accggcatgg cggaggtccg
    21061 gacatgatcc gggttatgcc ccccgcccgc ctgccgcgcg ccggccttcg ggtctgcgct
    21121 gtcgcctgca ccggcctcat gctgtcggcc cagcccggtg cggccgagat accggccgag
    21181 accgcctatg tcctcaactc gctttcgttc ctctaccatg ggatgctggt cttcttcatg
    21241 gcgaccgggt tctcgatgct cgagggcggg ctcgtccgaa ccaagagcgt gtcgacgatc
    21301 ctgctgaaga atgtgatcct gatcgcggtc gcgatgatcg ggttctacct cgtcggctac
    21361 aacctgatgt tctacaacgt ggacggcggg tactggggca cgccccgggc ctggtcgccg
    21421 gaccagaccg acgcgctgtc gcagggcgcg gcgcccgcgt cgatctggct gttccagacg
    21481 ctgtttgcgg tgaccgctgt gtccatcatt tcggggacgc tggccgaacg gatgcgtctg
    21541 ctgccgttct tcgtcttcgt cgccttcatg tcctgcgtgc tctatcccgt tcagggcgcc
    21601 tggggctggg gcgggggatg gctggccgag atggggttcc tggatttcgc cgggggaacc
    21661 catgtccaca gcgctgccgg ctgggcggcc ctaaccgggg ctatcgtgct tggcccgcgg
    21721 cgcagccggt tcgccgacag cggagaagtg cggcccatgg cggcgtcgtc gctgccgctg
    21781 gtgacactgg ggacgatgat cctgtggctt ggctggctgg ggttcaacgg cggttcgcag
    21841 ggatcgatgg attccgtcgc cgatgtgatc gcgatcgcga atatctacgt caacaccctg
    21901 atggcgacct gcggcggcat cgtcgcgacc gctgcgctgc ttcaacttct gcgtcgcaag
    21961 atcgacctca ccatggtgct gaacggggcg ctggcggggc tcgtcagcat caccgcgggt
    22021 ccggatacct caggcattgt cggcgcgctg ctgatcggcg cggtcggcgg ctgcctcatg
    22081 ctctggacca cgcacctgtt gcttcggctg aggatcgacg acgtgatcgg tgcgatcccg
    22141 gtgcacctcg cttgcgggat ctggggcacg ctcgtcgtca gcctgcatca cccggaggga
    22201 gacatcaggg tacagctgat cggcgtggcg gcggtcgcgg tcttctgtgt gacggccagc
    22261 gtcgtggtct ggatcggcct gcgtcgcttc atgcggctgc gactgagcca gggggaggaa
    22321 gcgatcggta tcgaccgggt cgagaccggg gcgctggcct atccggaatt cgcgacgcgg
    22381 tcggtcctac cgggagactg atatggcgag tccgaaacgg aacgcttcga agggggccgg
    22441 tgaacaagcg ttcaacggcc cttttgctgt ctgatccagg tcgatcccag ccaccgcttg
    22501 cggtggccac tgacaaattc cgtgggtgct gaaatatgta ccgccgaatg tgtcagtcgg
    22561 tgacacaggt cttacacttc cccgggtttc gcgaggtcat cgggacaagt cccgctccta
    22621 gaacactccc atcaacggtc ggtcaccagc gcacagcacg ggccggcgca tacgaaaatt
    22681 gatgaggaga taaggaatgt ggagtcttac caccaatgta ttctcgctgc cggcactctt
    22741 cggcatccga ggttccatgg cccgcccggc gggtgaaacg gacactcgga tcgtcgccgc
    22801 cctgagggaa ttgtcgacct tcgaagatca cgagttgagc gacatcggcc tctgtcggtc
    22861 cgacctgacg ccggagggct tggtccttgc cggtgagcgc cggaagacgc agcaggccgc
    22921 catcgacagg gaagccgcct tctccgtcag cgcggtccgg agggccaact gatgggagcg
    22981 cgttttcaag atatcagggg cctcgggcgg gccggccttt ccctcgtcgc ggatgacct
//
