LOCUS       NZ_CP031598            10855 bp    DNA     circular CON 28-MAR-2024
DEFINITION  Roseovarius indicus strain DSM 26383 chromosome, complete genome.
ACCESSION   NZ_CP031598
VERSION     NZ_CP031598.1
KEYWORDS    RefSeq.
SOURCE      Roseovarius indicus
  ORGANISM  Roseovarius indicus
            Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
            Roseobacteraceae; Roseovarius.
REFERENCE   1  (bases 1 to 5445172)
  AUTHORS   Vollmers,J. and Petersen,J.
  TITLE     Genetic Globetrotter - A new plasmid hitch-hiking vast phylogenetic
            and geographic distances
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 5445172)
  AUTHORS   Petersen,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (12-AUG-2018) Single Cell Genomics, Leibniz Institute
            DSMZ, Inhoffenstr. 8, Brunswick 38126, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: FEB-2018
            Assembly Method                   :: HGAP v. 3
            Assembly Name                     :: DSMZ_RIdsm
            Expected Final Version            :: yes
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: PacBio RS; Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_008728195.1-RS_2024_03_28
            Annotation Date                   :: 03/28/2024 05:52:02
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,061
            CDSs (total)                      :: 6,008
            Genes (coding)                    :: 5,925
            CDSs (with protein)               :: 5,925
            Genes (RNA)                       :: 53
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 47
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 83
            CDSs (without protein)            :: 83
            Pseudo Genes (ambiguous residues) :: 0 of 83
            Pseudo Genes (frameshifted)       :: 24 of 83
            Pseudo Genes (incomplete)         :: 57 of 83
            Pseudo Genes (internal stop)      :: 17 of 83
            Pseudo Genes (multiple problems)  :: 15 of 83
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:57:17
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 590582
            Orig. end                         :: 601437
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP031598.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10855
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="3"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10855
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10855
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5855](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5855)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    complement(217..233)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 17.98"
                     /tool="antismash"
     misc_feature    complement(453..464)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 17.24"
                     /tool="antismash"
     misc_feature    complement(1009..1024)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.44"
                     /tool="antismash"
     gene            complement(1385..1921)
                     /locus_tag="RIdsm_RS02955"
                     /old_locus_tag="RIdsm_00595"
     CDS             complement(1385..1921)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009157328.1"
                     /locus_tag="RIdsm_RS02955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RIdsm_00595"
                     /product="hypothetical protein"
                     /protein_id="WP_057820935.1"
                     /transl_table=11
                     /translation="MAERSQTYLWAMRALFVGICTLFVFLRLLPLDTLPRGWAGPDFIL
                     AFTLAWGLRRPEFVPPLLVALVFLLCDLLFHRPPGLWAALVLIGSQTLRARAPDLRDLT
                     FPVEWVSVATTLVAMTIGYRLILGLLMVDQAPLGLSLMEMVMTLIAYPVVVLVSQSLLG
                     VRKVAPGELDAMRPG"
     gene            complement(1914..2846)
                     /gene="mreC"
                     /locus_tag="RIdsm_RS02960"
                     /old_locus_tag="RIdsm_00596"
     CDS             complement(1914..2846)
                     /codon_start=1
                     /gene="mreC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009160825.1"
                     /locus_tag="RIdsm_RS02960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RIdsm_00596"
                     /product="rod shape-determining protein MreC"
                     /protein_id="WP_057820937.1"
                     /transl_table=11
                     /translation="MAKDRNQEGDYSGQLRRLLVGVLLLCLFGLFLVWRIDSPRIERFR
                     AQVIDRVVPSFDWAMAPVTGAVNIVHDFQSYQRIYQQNQELRRELQQMKAWKEAALQLE
                     QENARLLDLNNVQLDPRLTFVTGVVLADSGSPFRQSVLINVGARDGIVDGWAAMDGLGL
                     VGRISGVGNNTARVILLTDTSSRIPVTIEPSGQQALVSGDNTPSPIVSFLEAPDRVRPG
                     DRVITSGDGGVFPADLHVGQLTKDPGGRLRVRLSADYERLEFLRVLRNWRDERISDPGG
                     LVTPFGPIPNPIEPENTAEDSVVGEPADG"
     gene            complement(2993..4039)
                     /locus_tag="RIdsm_RS02965"
                     /old_locus_tag="RIdsm_00597"
     CDS             complement(2993..4039)
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0000902 - cell morphogenesis [Evidence
                     IEA]"
                     /GO_process="GO:0008360 - regulation of cell shape
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011537821.1"
                     /locus_tag="RIdsm_RS02965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RIdsm_00597"
                     /product="rod shape-determining protein"
                     /protein_id="WP_057820969.1"
                     /transl_table=11
                     /translation="MSIFSNIPGLFSSDMAIDLGTANTLVYVKGRGVILSEPSVVAYHV
                     KDGVKKVLAVGEDAKLMLGRTPGSIEAIRPMREGVIADFDTAEAMIKHFIRKVHKRSTF
                     SKPKIIVCVPHGATPVEKRAIRQSVLSAGARRAGLVAEPIAAAIGAGMPITDPTGNMVV
                     DIGGGTTEVAVLSLGDIVYARSIRVGGDRMDEAIINYLRRQLNLLVGESTAERIKTSIG
                     TARMPDDGRGTSMQIRGRDLLNGVPKETEITQAQVAEALAEPVQAICEAVMTALETTPP
                     DLAADIVDRGVMLTGGGALLGDLDLALREQTGLAVSIADDSLNCVALGTGKALEFEKQL
                     RHAIDYDS"
     misc_feature    complement(4020..4034)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 17.32"
                     /tool="antismash"
     misc_feature    complement(4154..4165)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 16.35"
                     /tool="antismash"
     gene            complement(4161..4997)
                     /locus_tag="RIdsm_RS02970"
                     /old_locus_tag="RIdsm_00598"
     CDS             complement(4161..4997)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF021364.4"
                     /locus_tag="RIdsm_RS02970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RIdsm_00598"
                     /product="DNA-binding domain-containing protein"
                     /protein_id="WP_057820940.1"
                     /transl_table=11
                     /translation="MPRTLAELQAALQNDVLHRQSTTRDSLSVPQGTSAESRLAVYQNA
                     YEIRLVNILGEDYDTLWTFVGDATFHELATGYLRDNPSTSRNARWVGHEFPAYLARHPI
                     GAQVPVLPELALMERAIRDAFDAPDAPVAAPEDLATIADHVETAVFTLHPGLTLIPTQT
                     NAYDIFLALRAGQTPPPPAEQDSVRWIVAWRRDLRSHHMELTPEEGTLLDLAARGSTFA
                     HLCEVASMMGEPDTTAARMGGTLRRWLENGMLSAMGPETPAQESGKSTPAPTAPAG"
     gene            complement(5001..5855)
                     /locus_tag="RIdsm_RS02975"
                     /old_locus_tag="RIdsm_00599"
     CDS             complement(5001..5855)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009811474.1"
                     /locus_tag="RIdsm_RS02975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RIdsm_00599"
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_074940559.1"
                     /sec_met_domain="DUF692 (E-value: 2.6e-103, bitscore:
                     343.2, seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVDRPPFLGFGLGLRPQHYTEILEADTPPPIDWFEIISENYMEAG
                     GRPRHMLDRVKDRYPLVMHGVSMSIASTSPLDWGYLERLKSLADHVQPKWISDHLCWTG
                     VHGINLHDLMPVAYTEEALTHITARIARVQDYLGRRIAIENVSSYIEFAESEMTEWEFV
                     GELARRADCWLLLDVNNVFVSGQNHRFDGNAFIEAIPTDRVVQFHLAGHSEGADCLIDT
                     HDQPVCDEVFELYRRAIGHFGPISTMIERDDNIPPLAELLAELARARQIAAETLAPGQL
                     KVA"
     gene            complement(5950..6213)
                     /locus_tag="RIdsm_RS02980"
                     /old_locus_tag="RIdsm_00600"
     CDS             complement(5950..6213)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003213503.1"
                     /locus_tag="RIdsm_RS02980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RIdsm_00600"
                     /product="hypothetical protein"
                     /protein_id="WP_057820944.1"
                     /transl_table=11
                     /translation="MKHATKSGTAIASAAFALALSGPAALAPSAATADEAKIHCMGVNT
                     CAGTSDCATASNSCAGQNSCKGQGFLSMTKAECDEAGGTVES"
     misc_feature    6166..6175
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.07"
                     /tool="antismash"
     gene            complement(6322..7224)
                     /locus_tag="RIdsm_RS02985"
                     /old_locus_tag="RIdsm_00601"
     CDS             complement(6322..7224)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1085:
                     binding-protein-dependent transport systems"
                     /gene_kind="transport"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="RIdsm_RS02985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="RIdsm_00601"
                     /product="hypothetical protein"
                     /protein_id="WP_057820946.1"
                     /transl_table=11
                     /translation="MKQIFHEVPLHHPAPNPDSIRPPARFAVAIPLAITLAVLLVTALA
                     PLIAPFGQTEIVGQPFQPPDETHLLGTDAFGRDFVTRIIYGLRNSVGLALAVAVLSLSI
                     GVAASALATALGTWPAAILFLLAQALSTFPAFYWAFFIIAVFPPSGPTLITALTLALAP
                     RVFRLCSTETMPASQRDALAASRSRLPVLRLVTALLRNEGVLLAAMFGIVFNIAFLTEV
                     AMSVFGMGVPFPLASIGGTAVRNMTLLSFGDFIPIYILVLITVFATSVSLLVDWLQRRS
                     GRPLVPSFRSYGPVWDIQR"
     tRNA            complement(7531..7605)
                     /anticodon=(pos:complement(598153..598155),aa:Thr,seq:ggt)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="RIdsm_RS02990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="RIdsm_00602"
                     /product="tRNA-Thr"
     gene            complement(7531..7605)
                     /locus_tag="RIdsm_RS02990"
                     /old_locus_tag="RIdsm_00602"
     misc_feature    7600..7614
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.3"
                     /tool="antismash"
     gene            7807..7968
                     /locus_tag="RIdsm_RS30010"
                     /old_locus_tag="RIdsm_00603"
     CDS             7807..7968
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008334894.1"
                     /locus_tag="RIdsm_RS30010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RIdsm_00603"
                     /product="hypothetical protein"
                     /protein_id="WP_177228442.1"
                     /transl_table=11
                     /translation="MTKKHPDKAPPAKKDSREDRLKAALKANMARRKAQMRGRKSAAGA
                     DEADEDKG"
     gene            7968..9236
                     /gene="murA"
                     /locus_tag="RIdsm_RS02995"
                     /old_locus_tag="RIdsm_00604"
     CDS             7968..9236
                     /EC_number="2.5.1.7"
                     /GO_function="GO:0008760 - UDP-N-acetylglucosamine
                     1-carboxyvinyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="murA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009805410.1"
                     /locus_tag="RIdsm_RS02995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RIdsm_00604"
                     /product="UDP-N-acetylglucosamine
                     1-carboxyvinyltransferase"
                     /protein_id="WP_057820948.1"
                     /transl_table=11
                     /translation="MDSILVRGNGQLNGDIPIAGAKNACLTLMPATLLSEEPLTLTNAP
                     RLSDIRTMSLLLQSLGAEVMGMQEGKVLTMSSHDLKSHVADYDIVRKMRASILVLGPLL
                     ARDGHAVVSLPGGCAIGARPVDLHLKALEAMGAELELKDGYVHATAKGGLAGGVVEFPL
                     VSVGATENALLAATLAKGTTVLKNAAREPEIVDLARCLRKMGAQIEGEGTSEITIQGVD
                     RLNGATHPVVPDRIELGTYMLAPAMCGGAVECLGGRLELVEAFSEKLDEAGITVEETER
                     GVKVSRGNGRVKAVDVTTEPFPGFPTDLQAQMMALMCTAEGTSVLEEKIFENRFMHAPE
                     LMRMGAKIDVQGGTAKVTGVERLKGAPVMATDLRASVSLILAGLAAEGETLVNRVYHLD
                     RGYESVEEKLGNVGAQIERVKGS"
     gene            9233..9703
                     /locus_tag="RIdsm_RS03000"
                     /old_locus_tag="RIdsm_00605"
     CDS             9233..9703
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009812533.1"
                     /locus_tag="RIdsm_RS03000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RIdsm_00605"
                     /product="DUF2948 family protein"
                     /protein_id="WP_057820950.1"
                     /transl_table=11
                     /translation="MSDDARFEDGREAPLNLGAFDPEDLQVLSSLVQDAVFPVTEMTWR
                     PRERRFALLLNRFRWEDQGRDRHGAERVQSVLAIDHVLKVSSQGIDRSEKDMVLSLLAV
                     EFEPGEDGTGYVMLTLAGDGAIRLAVEALEVSMKDVTRPYKAPSGKAPDHGD"
     gene            9709..10179
                     /locus_tag="RIdsm_RS03005"
                     /old_locus_tag="RIdsm_00606"
     CDS             9709..10179
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011241920.1"
                     /locus_tag="RIdsm_RS03005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RIdsm_00606"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_057820952.1"
                     /transl_table=11
                     /translation="MERVRAARPEDAPRISAVLIASIRELCAPDHEGDVAAIDAWIANK
                     TPEQVAVWLEGEHGVRVAVEGGEIAAVGAVSGAGEVLLLYVAPEYRGRGHSAALLEVLE
                     AELSEAGHDEARLVSTKTAHGFYLRHGWRNDGPEVACFRTRGQPMRKPLGPA"
     gene            complement(10189..10584)
                     /locus_tag="RIdsm_RS03010"
                     /old_locus_tag="RIdsm_00607"
     CDS             complement(10189..10584)
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007793652.1"
                     /locus_tag="RIdsm_RS03010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="RIdsm_00607"
                     /product="cytochrome c"
                     /protein_id="WP_057820954.1"
                     /transl_table=11
                     /translation="MTGMKSTIAGALGGLLLTGAAFADDLGKDLYMNSCATCHGESAAG
                     DGPLAELMTVGVPALTGLSAANEGEFPMLKVIQTIDGRQGTRGHGYPMPVWGKRLARDL
                     DTDDYGSEEIIRGRILSIAYYLESLQE"
ORIGIN
        1 atggccagct gcaagggcga ggccagcacg aagccctggc cgatggcggc gttgacgctg
       61 tcgccgatga cccattcggc gctgcggttg atgagcttcc attccttggt gggggcaagc
      121 cccgaggcga cggaggtcag cggcagttcg tgttcgatgc cgatgccgag cttgcgggcc
      181 atttccgaga tcttctcgat gccgacgcgc agggccatgt cgtaatagaa cacgtcgcag
      241 ctttcgcgga gcgaacggtg caggtcgaca ttaccgtggc ccgcgcgttt ccagcagtgg
      301 aagcggcggt tgctgacttc gagatggccg gggcaataga cggtttcggt gaggtccagc
      361 tcgcccgctt ccagcgcggc gagcgccacg accatcttga aggtcgagcc cggagggtag
      421 atgccctgca ccgccttgtt gggcagggga cggtattcgt tttcgagaag cgcgttgtaa
      481 ttggcgaccg agatgccccg cacgaagagg ttggggtcga agctgggcgc cgaggcgctg
      541 gccagaaggt cgccgctttc gcaatcgacc accaccgccg ccgcgctttc gccggcaagg
      601 cgggcgtggc agtaggtttg caggttgttg tcgatcgaga tctggatgtc cttgccggag
      661 gtgccctcct gccgttccag ttcgcgcatc acgcggccgg cggcgttgac ctcgacccgc
      721 ttggtgccag cctcgccgcg caggagttcc tcctgccggg cctcgaggcc gatcttgccg
      781 atctggaagc gcgggatgag cagcagcgcg tcgggcgcgt cgatgcgttc gagatcgcgg
      841 tcgctgaccg gccccacgta gcccacgagg tgggcatagg cctcgccttg cgggtagcgg
      901 cgagacaggc ccacgtcggg cgtgacgccg ggcagggcgg gcgtgttcac cgcgatgcgg
      961 ctgatatctt cccagctgac gcggtcggcg agggtgacgg gcgtgtcgcc gcgcaggcgt
     1021 tcgaggtcgc ggcgggcgcg gtcgagctcc tcggggtcga gggtgaccag cttggaaagc
     1081 cgggcgatca cctcttcgac gtcgcccgcc tcctcgcgca ccatggtgat gcggtagctg
     1141 ggcacgttct cggcgacggt ggtgccgttg cggtcgaaga tgcggccgcg cgtcggcgga
     1201 atcaggcgga tgttgatgcg gttctcgtcg gcgagcaggc ggaactggtc ggcctgttcg
     1261 acctgcaggt agcgcatgcg cagcgccagc gtgccgacga tggcggacat gccgccgccg
     1321 atgatcagcc cgcggcgggt gatcttgcgg tagctttcgg cggtatcgcg tgtcgggcgt
     1381 ctcatcagcc gggcctcatc gcgtcgagct cgcccggggc gaccttgcgc acgccgagca
     1441 gggattgcga gaccagcacc accaccgggt aggcgatgag ggtcatgacc atttccatca
     1501 ggctcagccc gaggggggcc tggtcgacca tcagcagccc gaggatcagc cggtagccga
     1561 tggtcatcgc caccaatgtg gtggcgacgc tgacccattc aacggggaag gtgaggtcgc
     1621 gcaggtcggg ggcgcgggcg cggagggtct ggctgccgat cagcaccagc gccgcccaga
     1681 ggccgggcgg gcggtggaac agcaggtcgc agagcaggaa gacgagggcc accagcagcg
     1741 gcggcacgaa ttccgggcgg cgcaggcccc aggcgagggt gaaggcgagg atgaagtcgg
     1801 gccccgccca gccgcgcggc agggtgtcga gcggcagcag gcgcaggaac acgaacagcg
     1861 tgcagatgcc gacgaagagg gcgcgcatgg cccagagata tgtctggctg cgctcagcca
     1921 tcggcgggct ctccgacgac gctgtcctcg gcggtgtttt ccggctcgat cgggttgggg
     1981 atcggcccga acggcgtgac gaggccgccc gggtcggaaa tccgctcgtc gcgccagttg
     2041 cgcaggacgc ggaggaattc gaggcgttcg taatcggccg agaggcgcac gcgcaggcgg
     2101 ccgccggggt ctttcgtgag ttgacccacg tgcaggtcgg cggggaagac gccgccatct
     2161 cccgaggtga tcacccggtc gccggggcgc acccggtcgg gggcttcgag gaagctgacg
     2221 atgggcgaag gcgtgttgtc gcccgagacc agcgcctgtt ggcccgaggg ttcgatggtg
     2281 acggggatgc ggctggaagt gtcggtgagc aggatgacgc gcgcggtgtt gttgcccacg
     2341 cccgagatgc ggccgacgag gccgagacca tccatcgccg cccagccgtc gacgatgccg
     2401 tcgcgggcgc cgacgttgat cagcaccgat tgccggaagg gcgagccgct gtcggccagc
     2461 accacgccgg tgacgaaggt caggcgcggg tcgagctgca cgttgttgag gtcgagcagg
     2521 cgggcgtttt cctgttcgag ctgaagcgcc gcttccttcc acgccttcat ctgttgcagt
     2581 tcgcggcgga gttcctggtt ctgctggtag atgcgctggt agctctggaa atcgtggacg
     2641 atgttgaccg cgcccgtgac cggcgccatc gcccagtcga agctgggtac gacccggtcg
     2701 atcacctggg cgcggaagcg ttcgatgcgg gggctgtcga tgcgccagac caggaacagg
     2761 ccgaacaggc acaggagcag cacgcccacc agcagacggc gaagctggcc ggagtagtcg
     2821 ccttcctggt ttctgtcctt tgccaacggc tgccccttcg tcagacaggt ggatggcgtg
     2881 gagtggccgg aatgtcagcc gggtatcggc ccggatcccg atccgccttc aacatcaata
     2941 cgttccgggc ggtccgcgcc agtgtttccg tgcgaggata gcgcaaatcg ccttagctgt
     3001 cgtagtctat cgcgtgtcgc agctgttttt caaactccaa cgccttgccg gtgccgagag
     3061 cgacgcaatt caggctgtca tcggctatcg aaacggcaag accggtctgt tcgcgcagcg
     3121 cgaggtcgag atcgcccaga agggcgccgc cgccggtcag catgacgccc cgatcgacga
     3181 tgtccgccgc aaggtcgggc ggggtggttt cgagcgcggt catcaccgcc tcgcagatgg
     3241 cctgcaccgg ttcggccagc gcctcggcga cctgggcctg ggtgatctcg gtttccttgg
     3301 gcacgccgtt cagaaggtcg cggccgcgga tctgcatcga ggtgccgcgc ccgtcatcgg
     3361 gcatgcgggc ggtgccgatc gaggtcttga tgcgctcggc cgtcgactcg cccaccagca
     3421 ggttcagctg gcggcgcagg tagttgataa tggcttcgtc catccggtcg ccgccgacgc
     3481 ggatcgagcg ggcatagacg atgtcgccca gcgacaggac ggccacctcg gtggtgccgc
     3541 cgccgatatc gacgaccatg ttgccggtcg ggtcggtgat gggcatgccg gcgccgatgg
     3601 ccgccgcgat gggttcggcc acgaggcccg cgcggcgcgc gccggccgac agcaccgatt
     3661 ggcgaatcgc gcgtttttcc accggggtgg cgccgtgggg cacgcagacg atgattttcg
     3721 gtttcgagaa ggtcgagcgt ttgtgcacct tgcggatgaa gtgcttgatc atcgcctcgg
     3781 cggtgtcgaa atcggcgatc acgccttcgc gcatcgggcg gatcgcctcg atgctgccgg
     3841 gggtgcggcc cagcatgagc ttggcgtctt cgccgacggc gagcactttc ttgacgccgt
     3901 ctttcacgtg gtaggccacc accgaaggtt cggacaggat gacgccgcga cccttgacgt
     3961 agaccagcgt gttcgcagtc ccgaggtcga tcgccatgtc cgacgagaat agcccgggga
     4021 tattactgaa gattgacatc tgcgcctgct gatccatcgc ccaattgata ctttggccgc
     4081 cgagtcggag cccggaagcc gagtgagtta tagagtgcgt gccggatggg tgaaaggggc
     4141 agtttcaaac ggcgtaagcg ttatcctgcc ggggcggtgg gggccggggt ggatttgccg
     4201 ctttcctgtg cgggcgtttc cggccccatg gccgagagca tgccgttttc cagccagcgg
     4261 cggagggtgc cgcccatgcg ggcggcggtg gtgtcgggtt cacccatcat ggaagcgacc
     4321 tcgcagagat gggcgaaggt gctgccccgg gcggcgaggt cgaggagggt gccttcctcg
     4381 ggcgtcagtt ccatgtggtg gcttctcagg tcgcggcgcc acgcgacgat ccaccgcacg
     4441 ctgtcctgtt ctgcgggggg cggcggggtc tgcccggcgc gcagggcgag gaagatgtcg
     4501 taggcgttgg tttgcgtggg gatcagagtg aggccggggt gaagggtgaa gacggccgtc
     4561 tcaacatgat cggcgatggt ggcgaggtct tcgggggcgg ccacgggggc atcgggcgcg
     4621 tcgaaggcat cgcggatggc gcgttccata agggcgagct cgggcagaac gggaacctgt
     4681 gcgccgatgg gatgccgggc gagataggcc gggaattcat ggcccaccca ccgggcattg
     4741 cgcgaggtgg agggattgtc gcgcaggtag ccggtggcaa gctcgtggaa ggtggcatcg
     4801 cccacgaagg tccagagcgt gtcgtaatcc tcgcccagga tgttcacgag gcggatttca
     4861 taggcgttct ggtagacggc gaggcggctt tcggcgctgg tgccttgcgg cacggaaagg
     4921 ctgtcgcgcg tggtggactg gcgatgcagc acgtcgttct gcagcgcggc ctgaagctcg
     4981 gcgagggtgc ggggcatggg tcaggccact ttcaactggc cgggcgcgag ggtttccgcg
     5041 gcaatctggc gggcgcgggc gagttcggcg agcagttccg ccaagggcgg gatgttgtcg
     5101 tcgcgctcga tcatcgtcga gatcgggccg aaatggccga tggcgcggcg gtagagctcg
     5161 aacacctcgt cgcagaccgg ctggtcatgg gtgtcgatca ggcagtcggc gccttcgctg
     5221 tggcccgcga ggtggaattg cacgacgcgg tctgtcggga tggcctcgat gaaggcgttc
     5281 ccatcgaacc ggtggttctg gccggaaacg aagacgttgt tcacgtcgag cagcagccag
     5341 caatcggcac ggcgggccag ctcgcccacg aattcccact cggtcatctc cgactcggca
     5401 aactcgatgt aggaggaaac gttctcgatg gcgatgcggc ggccgagata gtcctgcacg
     5461 cgggcgatgc gggcggtgat gtgggtcagc gcttcctcgg tataggcgac gggcatgagg
     5521 tcatgcaggt tgatgccatg cacgcctgtc cagcagaggt ggtcggagat ccacttgggc
     5581 tggacatggt cggcgaggga tttcaggcgt tcgagataac cccagtcgag cggagaggtg
     5641 gaggcgatgg acatcgacac gccgtgcatc accagcgggt agcggtcttt tacgcggtcg
     5701 agcatgtggc gggggcggcc gccggcctcc atgtagttct cggaaatgat ctcgaaccag
     5761 tcgatgggcg ggggcgtgtc ggcctcgagg atctcggtgt aatgctgggg cctgaggcca
     5821 aggccgaagc caaggaacgg ggggcggtcg accatcatgc tcctcctgtg acggtgccgg
     5881 cagtgtaacg gcaaaccggg cccctgtccg ccttggcgga cgaggcccgg ggttgtttgg
     5941 agggggcggt cagctttcga cggtaccgcc ggcctcgtcg cattcggcct tggtcatcga
     6001 caggaagccc tggcccttgc agctgttctg cccggcgcaa gagttgctgg cggtggcgca
     6061 gtcgctggtg ccggcgcagg tgttgacgcc catgcagtgg atcttggcct cgtccgcggt
     6121 ggcggccgag ggggcaaggg cggcggggcc cgagagggca agggcgaagg cggcggaggc
     6181 gatcgcagtt ccggatttgg tggcgtgttt catcgttaag ctcctcttct tgtacgatgg
     6241 attgcaaagc gaccatcggg cggaatgtct gtcacgggca actaaactta tcgttacgcg
     6301 acgtcagttt ggggggagcc gtcaccgctg gatgtcccag acggggccgt aacttcggaa
     6361 gctgggcaca aggggccggc cggaacggcg ctgcagccag tcgacgagga gggagaccga
     6421 cgtggcgaag accgtgatga ggacgagaat gtagatcggg atgaagtcac cgaagctgag
     6481 cagggtcatg tttcgcacgg cggtgccccc gatggacgcc agcggaaagg gcacgcccat
     6541 gccgaagacc gacatcgcga cctcggtcag gaaggcgatg ttgaagacga tgccgaacat
     6601 ggccgccaga agcacgcctt cgttgcggag gagggccgtc acgagacgga ggacgggcag
     6661 gcgggagcgg gaggcggcga gggcgtcgcg ctggctggcc ggcatggttt cggtgctgca
     6721 cagccggaag acccgtggcg ccagtgccag ggtcaaggcc gtgatcaggg tcgggcccga
     6781 cggggggaag acggcgatga tgaagaaggc ccagtagaag gccgggaacg tggacagggc
     6841 ctgggccagg aggaaaagga tggcggcggg ccatgtcccg agggccgtgg cgagcgcgct
     6901 ggcggccacg ccgatggaga gcgacaggac ggccacggca agcgcgagcc cgacgctgtt
     6961 gcgcaggccg tagatgatgc gcgtcacgaa atcccgcccg aaggcgtcgg ttccgagaag
     7021 gtgggtttcg tcgggcggct ggaagggctg gcccacgatc tccgtctggc cgaacggggc
     7081 gatcaggggc gcgagggccg tcacgagcag gacggcgagc gtgatggcca gggggatggc
     7141 gacggcgaaa cgggccgggg ggcggatgct atcgggattg ggggcggggt gatgaagtgg
     7201 aacttcgtgg aaaatctgct tcatgacacg gctccgttgc aatgcgggaa ccgtaggcgc
     7261 aggacattgc cgggtaaacc gtagacgggc gttgggcgac ggtggcgagt tgtattcccg
     7321 gttgtcacag ggcggcggga agagacgcgg cgaaggtcgc aatcgtgtcc atgagcggac
     7381 ctatcgacga agcgcctgtg cggactcgag accgtggggt gcgacgaccg cctcgttcgc
     7441 actgcggtca tttcgacatt ggctgcccct gttcgggcgc accgcgtcgg atgaaagccg
     7501 cagggctgtc cggcaatgtt cgggagggac tggtgctgct ggggaggatt gaactcccga
     7561 cctcaccctt accaagggtg cgctctacca ctgagctaca gcagcctcgt cgatggcggg
     7621 cctcttagac cgatccgcgc cgccgcgcaa gggctatctg gccgggattt tcacccattt
     7681 gccggttggc ggggaaaaac cgcggaaccg ggattttgca cggccccttc ccctgttata
     7741 tacgccgctt gctgtttcgc cgtcttgatt tctgggctac aacgcggaac acagtaggac
     7801 ggcacgatga cgaagaaaca ccccgacaag gcgccccccg ccaagaagga cagccgggaa
     7861 gaccggttga aggccgcgct gaaggccaac atggcgcggc gcaaggcgca gatgcggggc
     7921 agaaaaagtg ccgccggggc ggatgaggca gacgaggaca agggctgatg gattcgatac
     7981 ttgtaagggg caatggccag ctgaacgggg atatcccgat cgccggggcc aagaatgcct
     8041 gtctgacgct gatgccggcg acgcttctga gcgaggagcc gctgacgctg accaatgcgc
     8101 cgcggctgtc ggatatccgc acgatgagcc ttctgctgca gagcctgggc gccgaggtga
     8161 tgggcatgca ggagggcaag gttctgacca tgtcgagcca tgacctgaag agccacgtgg
     8221 ccgattacga catcgtgcgg aagatgcgcg cgtcgatcct ggtactcggc ccgcttctgg
     8281 cgcgcgacgg gcatgccgtg gtgtcgttgc cgggcggctg tgccatcggg gcgcgtccgg
     8341 tcgacctgca tctgaaggcg ctcgaggcga tgggcgcgga gctggagctg aaggacggct
     8401 acgtgcacgc caccgccaag ggcgggctgg ccggcggcgt ggtggagttt ccgctggtgt
     8461 cggtgggcgc gacggaaaac gcgcttctgg ccgcgacgct ggccaagggc acgacggttc
     8521 tgaagaacgc cgcgcgcgag cccgagatcg tcgacctggc gcgctgcctg cggaagatgg
     8581 gcgcgcagat cgagggcgag ggcaccagcg agatcaccat ccagggggtc gaccggctga
     8641 acggcgcgac gcaccccgtc gtgcccgacc ggatcgagct gggcacctac atgctggcgc
     8701 ctgccatgtg cggcggggcc gtggaatgcc tgggcggccg gctggagctg gtcgaggcgt
     8761 tcagcgagaa gctagacgag gccggcatca ccgtcgagga aaccgagcgc ggcgtgaagg
     8821 tgtcgcgcgg caacgggcgg gtgaaggcgg tcgatgtgac gacagagccg ttccccggct
     8881 tcccgaccga tttgcaggcc cagatgatgg cgctgatgtg caccgccgag gggacgagcg
     8941 ttctggaaga gaagatcttc gagaaccgct tcatgcatgc gccggaactg atgcggatgg
     9001 gcgcgaagat cgacgtgcag ggcggcaccg caaaggtgac gggtgtcgag cggctgaagg
     9061 gcgcgccggt gatggcgacc gacctgcggg cgtcggtgtc gctgatcctt gccgggctcg
     9121 cggccgaggg cgagacgctg gtcaaccggg tctatcacct tgaccgcggc tacgagagcg
     9181 tcgaggaaaa gctgggcaac gtgggcgcac agatcgaaag ggtgaagggc tcgtgagcga
     9241 tgatgcgaga ttcgaggatg ggcgcgaggc gccgctgaac cttggggcct tcgacccgga
     9301 ggaccttcag gttctgtcgt cgctggtgca ggacgcggtc tttcccgtga ccgagatgac
     9361 ctggcgccca cgcgagcggc gctttgccct gctgctgaac cgcttccgct gggaggacca
     9421 gggccgcgac cggcacggtg ccgagcgggt gcagtcggtt ctggccatcg atcacgttct
     9481 gaaagtgtcg agccagggca tcgaccggag cgagaaggac atggttctgt cgctgctggc
     9541 ggtggagttc gagccgggcg aggatggcac cggttacgtc atgctgacgc tggcgggcga
     9601 tggggcgatc cggctggcgg tcgaggcgct ggaggtgtcg atgaaggatg tcacccggcc
     9661 ctacaaggcg ccgtcgggca aggcgcccga tcacggggac tgacggcgat ggaacgtgtg
     9721 cgcgccgccc gacccgagga tgcgccgcgg atcagcgccg tgctgatcgc ctcgatcagg
     9781 gagctgtgcg cgcccgatca cgagggcgat gtcgccgcca tagacgcctg gattgccaac
     9841 aagacacccg aacaggtggc cgtctggctg gaaggcgagc atggtgtgcg tgtcgcggtc
     9901 gaggggggcg agattgccgc cgtcggtgcg gtgtcgggcg cgggcgaggt tctgttgctt
     9961 tacgtcgcgc ccgagtatcg cggccggggc cacagcgccg ccttgctgga ggtgctggag
    10021 gccgagctgt ccgaggcggg ccatgacgag gcgcgccttg tcagcaccaa gacggcgcat
    10081 ggcttctacc tgcgccatgg ctggcgcaat gacgggcccg aggtggcctg tttccgcacc
    10141 cggggccagc ctatgcgcaa accgctcggg ccggcctgaa aggcccggtt attcctgtag
    10201 gctttcgagg taataggcga tcgacaggat gcggccgcgg atgatttcct cggagccgta
    10261 atcgtcggtg tcgagatcgc gggcgaggcg cttgccccag accggcatcg ggtagccgtg
    10321 gccgcgcgtg ccctgccgcc cgtcgatcgt ctggatgacc ttgagcatcg ggaattcgcc
    10381 ctcgttcgcc gccgacaggc cggtgagggc cggcacgccg accgtcatca attcggccag
    10441 aggcccgtct ccggcggcgc tttcgccgtg acaggtggcg caggagttca tgtaaaggtc
    10501 cttgccgaga tcgtcggcaa aggcggcacc ggtcagcaga aggccgccca gggcgcctgc
    10561 gatcgtcgat ttcatgccgg tcatgtcagt ctccgtggct gatttctggg ttcaacgggg
    10621 tcatcccgtt gtttttgcct agcatgcggg ccatctggag gagttgacgc aagttaaccg
    10681 gccgccggcc ggcctggcgg cggcgcttgt ggcccgggcc gcaaagcctt atgcgaggcc
    10741 ccgtcaagga gagttgccat gccccatttt ctgaacgccg cggatgccgg tttcgaggaa
    10801 gacttcgccg ccctgctggg ggccaagcgc gaagaggcgc aggatgtgga cgatg
//
