LOCUS       NZ_VYTZ01000034         7501 bp    DNA     linear   CON 20-NOV-2024
DEFINITION  Microbispora cellulosiformans strain Gxj-6 Scaffold34, whole genome
            shotgun sequence.
ACCESSION   NZ_VYTZ01000034
VERSION     NZ_VYTZ01000034.1
KEYWORDS    WGS; RefSeq.
SOURCE      Microbispora cellulosiformans
  ORGANISM  Microbispora cellulosiformans
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Streptosporangiales; Streptosporangiaceae; Microbispora.
REFERENCE   1  (bases 1 to 7501)
  AUTHORS   Gong,X.
  TITLE     Screening of Novel Bioactive Compounds from Soil-Associated
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7501)
  AUTHORS   Gong,X.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-SEP-2019) College of Land and Environment, Shenyang
            Agricultural University, No. 120, Dongling Road, Shenhe District,
            Shenyang, Liao Ning 110866, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 2.04 OR JUL-2018
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 400x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_008728085.1-RS_2024_11_18
            Annotation Date                   :: 11/18/2024 02:05:44
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,471
            CDSs (total)                      :: 7,401
            Genes (coding)                    :: 7,312
            CDSs (with protein)               :: 7,312
            Genes (RNA)                       :: 70
            rRNAs                             :: 5, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 1 (5S, 16S)
            partial rRNAs                     :: 3, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 89
            CDSs (without protein)            :: 89
            Pseudo Genes (ambiguous residues) :: 0 of 89
            Pseudo Genes (frameshifted)       :: 7 of 89
            Pseudo Genes (incomplete)         :: 80 of 89
            Pseudo Genes (internal stop)      :: 8 of 89
            Pseudo Genes (multiple problems)  :: 6 of 89
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 09:06:26
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 7501
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            VYTZ01000034.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     gene            complement(<1..1605)
                     /locus_tag="F5972_RS36640"
                     /old_locus_tag="F5972_36645"
     CDS             complement(<1..1605)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: NRPS-COM_Nterm (1-28). E-value: 3.2e-12.
                     Score: 37.5. Matches aSDomain:
                     nrpspksdomains_F5972_RS36640_NRPS-COM_Nterm.1"
                     /NRPS_PKS="Domain: Cglyc (6-304). E-value: 3.8e-130. Score:
                     425.4. Matches aSDomain:
                     nrpspksdomains_F5972_RS36640_Cglyc.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Condensation"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127: condensation domain-containing protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012873.5"
                     /locus_tag="F5972_RS36640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F5972_36645"
                     /product="condensation domain-containing protein"
                     /protein_id="WP_225312229.1"
                     /sec_met_domain="Condensation (E-value: 2.5e-71, bitscore:
                     227.3, seeds: 42, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKESALAGVWPLSPLQEGMLFHSLFDEQNADVYVEQMIIGLEGEL
                     DAARLRASWQALLDRHESLRAGFRSRSSGAPVQLIMRRVTLPWREVDLSELPEDEAWAE
                     SERIGIEERAERFDLAVPPLLKVLLAKVAPSRYRMMVTLHHILVDGWSLPILMGELWRS
                     YEAGGTAEGLPPVTPYRHYLEWLARQDKDAAREAWRQALSDVEGPTLVAPAARDATPGH
                     CDSLTGEASAELDQALQELTRSHGVTLNTVVQTAWAVLLGKLTGRRDVVFGSVVAGRPM
                     DLPGVESMLGLFINTIPVRVPLDPSRTVAETLTRLQAQQSALMDAQYLSPSDIQRLAGP
                     GATFDTALAFENFPSGSGGNKPPADGASRPAGPGGLKFTENGLRESINYPLGLVAGSLG
                     GLKMRLTYRPDFFDESSAQALMDRMLRLLDQMAADPGARIAQLDVLGEAERRVVVEEWN
                     DTARVVGAGSLVELFGAQAGRTPDAVAVSEAVSDALPDGGVVWTYAELARVSDRVACGL
                     LARGVGRGVRVGVVMERS"
     source          1..7501
                     /collection_date="2015-04-30"
                     /db_xref="taxon:2614688"
                     /geo_loc_name="China: Heilongjiang Province, Heihe City"
                     /isolation_source="soil"
                     /mol_type="genomic DNA"
                     /organism="Microbispora cellulosiformans"
                     /strain="Gxj-6"
                     /submitter_seqid="Scaffold34"
                     /type_material="type strain of Microbispora
                     cellulosiformans"
     region          1..7501
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS"
                     /region_number="1"
                     /rules="cds(Condensation and (AMP-binding or A-OX) and not
                     alpha_am_amid)"
                     /tool="antismash"
     cand_cluster    1..7501
                     /SMILES="NC(c1cc(O)cc(O)c1)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(Condensation and (AMP-binding or
                     A-OX) and not alpha_am_amid)"
                     /kind="single"
                     /product="NRPS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..7501
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[1606:>7501](-)"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or A-OX)
                     and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(1607..>7501)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or A-OX)
                     and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     CDS_motif       complement(544..657)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_F5972_RS36640_0007"
                     /evalue="3.30E-16"
                     /label="C67_DCL_14fromHMM"
                     /locus_tag="F5972_RS36640"
                     /protein_end="354"
                     /protein_start="316"
                     /score="51.7"
                     /tool="antismash"
                     /translation="QAQQSALMDAQYLSPSDIQRLAGPGATFDTALAFENFP"
     aSDomain        complement(694..1587)
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_F5972_RS36640_Cglyc.1"
                     /domain_subtypes="Cglyc"
                     /evalue="3.80E-130"
                     /label="F5972_RS36640_Cglyc.1"
                     /locus_tag="F5972_RS36640"
                     /protein_end="304"
                     /protein_start="6"
                     /score="425.4"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHILVDG"
                     /tool="antismash"
                     /translation="AGVWPLSPLQEGMLFHSLFDEQNADVYVEQMIIGLEGELDAARLR
                     ASWQALLDRHESLRAGFRSRSSGAPVQLIMRRVTLPWREVDLSELPEDEAWAESERIGI
                     EERAERFDLAVPPLLKVLLAKVAPSRYRMMVTLHHILVDGWSLPILMGELWRSYEAGGT
                     AEGLPPVTPYRHYLEWLARQDKDAAREAWRQALSDVEGPTLVAPAARDATPGHCDSLTG
                     EASAELDQALQELTRSHGVTLNTVVQTAWAVLLGKLTGRRDVVFGSVVAGRPMDLPGVE
                     SMLGLFINTIPVRVPLD"
     CDS_motif       complement(706..801)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_F5972_RS36640_0006"
                     /evalue="4.70E-20"
                     /label="C5_DCL_263-294"
                     /locus_tag="F5972_RS36640"
                     /protein_end="300"
                     /protein_start="268"
                     /score="64.0"
                     /tool="antismash"
                     /translation="DVVFGSVVAGRPMDLPGVESMLGLFINTIPVR"
     CDS_motif       complement(883..1026)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_F5972_RS36640_0005"
                     /evalue="4.90E+00"
                     /label="C2_dual_024-063"
                     /locus_tag="F5972_RS36640"
                     /protein_end="241"
                     /protein_start="193"
                     /score="-0.2"
                     /tool="antismash"
                     /translation="AREAWRQALSDVEGPTLVAPAARDATPGHCDSLTGEASAELDQAL
                     QEL"
     CDS_motif       complement(1036..1074)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_F5972_RS36640_0004"
                     /evalue="1.60E-03"
                     /label="C4_DCL_171-183"
                     /locus_tag="F5972_RS36640"
                     /protein_end="190"
                     /protein_start="177"
                     /score="11.1"
                     /tool="antismash"
                     /translation="PYRHYLEWLARQD"
     CDS_motif       complement(1114..1179)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_F5972_RS36640_0003"
                     /evalue="8.40E-10"
                     /label="C3_DCL_135-156"
                     /locus_tag="F5972_RS36640"
                     /protein_end="164"
                     /protein_start="142"
                     /score="31.1"
                     /tool="antismash"
                     /translation="LHHILVDGWSLPILMGELWRSY"
     CDS_motif       complement(1399..1515)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_F5972_RS36640_0002"
                     /evalue="3.10E-20"
                     /label="C2_DCL_024-062"
                     /locus_tag="F5972_RS36640"
                     /protein_end="69"
                     /protein_start="30"
                     /score="64.5"
                     /tool="antismash"
                     /translation="DVYVEQMIIGLEGELDAARLRASWQALLDRHESLRAGFR"
     aSDomain        complement(1522..1602)
                     /aSDomain="NRPS-COM_Nterm"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_F5972_RS36640_NRPS-COM_Nterm.1"
                     /evalue="3.20E-12"
                     /label="F5972_RS36640_NRPS-COM_Nterm.1"
                     /locus_tag="F5972_RS36640"
                     /protein_end="28"
                     /protein_start="1"
                     /score="37.5"
                     /tool="antismash"
                     /translation="KESALAGVWPLSPLQEGMLFHSLFDEQ"
     CDS_motif       complement(1540..1575)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_F5972_RS36640_0001"
                     /evalue="1.50E-05"
                     /label="C1_dual_004-017"
                     /locus_tag="F5972_RS36640"
                     /protein_end="22"
                     /protein_start="10"
                     /score="17.6"
                     /tool="antismash"
                     /translation="PLSPLQEGMLFH"
     gene            complement(1607..>7501)
                     /locus_tag="F5972_RS36645"
                     /old_locus_tag="F5972_36650"
     CDS             complement(1607..>7501)
                     /NRPS_PKS="Domain: PCP (214-282). E-value: 1.1e-24. Score:
                     78.4. Matches aSDomain: nrpspksdomains_F5972_RS36645_PCP.1"
                     /NRPS_PKS="Domain: Condensation_LCL (296-599). E-value:
                     8.9e-112. Score: 364.9. Matches aSDomain:
                     nrpspksdomains_F5972_RS36645_Condensation_LCL.1"
                     /NRPS_PKS="Domain: AMP-binding (770-1196). E-value:
                     9.6e-105. Score: 342.4. Matches aSDomain:
                     nrpspksdomains_F5972_RS36645_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (1362-1429). E-value: 2e-21. Score:
                     68.0. Matches aSDomain: nrpspksdomains_F5972_RS36645_PCP.2"
                     /NRPS_PKS="Domain: Epimerization (1442-1754). E-value:
                     1.1e-127. Score: 418.7. Matches aSDomain:
                     nrpspksdomains_F5972_RS36645_Epimerization.1"
                     /NRPS_PKS="Domain: TIGR01720 (1767-1952). E-value: 6.4e-37.
                     Score: 118.7. Matches aSDomain:
                     nrpspksdomains_F5972_RS36645_TIGR01720.1"
                     /NRPS_PKS="Domain: NRPS-COM_Cterm (1936-1956). E-value:
                     8.6e-09. Score: 27.0. Matches aSDomain:
                     nrpspksdomains_F5972_RS36645_NRPS-COM_Cterm.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1047: phosphopantetheine-binding domain-containing
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012873.5"
                     /locus_tag="F5972_RS36645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F5972_36650"
                     /product="non-ribosomal peptide synthetase"
                     /protein_id="WP_191910505.1"
                     /sec_met_domain="PP-binding (E-value: 3e-18, bitscore:
                     53.4, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="Condensation (E-value: 1.2e-69, bitscore:
                     221.7, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 1.2e-116, bitscore:
                     376.7, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LARWRGDGQLVFAGRADEQVKIRGFRIEPGEIEAVLASHESVAQA
                     VVVAREDRPGDKRLIAYIVPTTENTIESGDTSDGSGTVGSSGAVGSSGAVGSGDSAGSS
                     DDAGGIGTAARDDTAESRASGDGSGLVVSGGGGGGGNSRSGSGSGGSVDTAGVRDHVAA
                     RLPEYMVPSAVVVLERLPVTANGKVDRAALPAPDLAGLAGSAGGRAPATPTEEVLCGLF
                     AEILGVEEIGTDASFFDLGGDSLRAMRLLARIRSVLNAEVSIRGLFAEPTVAGVARLID
                     GSGETRRALTPMPRPEALPLSYAQQRMWFLSRLEEVGGGANYNLPLALRLSGDLDITAL
                     EAAVGDVADRHESLRTIFPETDGVPRQHILDGPAGRPPLVVVETTSDQAGEVLAAQSSR
                     GFDLSVELPWRVRLLVTGPSEYVLLIVAHHIAVDGWSMGVLGRDLSTAYAARREGRAPE
                     WRPLPVQYADYALWQREVLGDLDDPGSLISGQLGYWRQALEGAPEELALPADRPRPAAS
                     SFRGGNVHLEVDAETHARLVELAQGGNATMFMVAHAALAVLLAKVGAGTDIPIGTAIAG
                     RGDAALEDLAGFFVNTLVLRADLSGDPSFEDVLARVRETDLAAYAHQDVPFERLVDELN
                     PTRSLSRNPLFQIMLAVQNATPPTWNLPALQVSSAQPSSEEVARFDLSVTLVERRDEAG
                     APAGLGGGVLYAADLFDESTAQALARRLVRVLEQVASDSSLRLSQVDVLEESERRSVVE
                     EWNATATPVVVGTVLDRFEEQADRAPDAVAVWCDGNGVSYREVEDAANQLASYLRELGV
                     GAESRVGLVLPRGVQLVVSILAAWKAGAGYVPIDPAYPADRIGFILADSAAQVVIGTTA
                     TLSGITTPETGTDANAETGASATASVGANSAAAETLTGAGGLRVVVLDDERTAERIDAQ
                     SAERFDVAVEASGLAYVIYTSGSTGRPKGVAVPHAGVANLAHAMRPALDVGPGVTALQF
                     ASFGFDAAVLDVAVTLAAGGTLAIATEAERAEPEALARMIGAAGVEVASVVPSLLSVLD
                     PEAVPGVRRWVLGAERLSARLAARWVGSGAEVWNTYGPTEASVITTASPIATPVEQDPA
                     IGAPLPNTAVFVLDDFLQPVPPGVTGELYIAGAGLARGYVGRPGMTGERFVACPFADGV
                     RMYRSGDLARWLNDGQLAFVGRADEQVKIRGFRIEPGEVEAVLASHESVTQVAVIVRED
                     RPGDKRLVAYVVPALNPDAQAPTVISPATASAGTASSGAASPDVAGSGALGEEGSPSGT
                     GMDVTGPDAASPADGGAVAARVDIAALREFAASRLPDYMVPLVVQIEAIPLTVNGKLDR
                     AALPAPDLPDAGRAAETPMEEILCGLFAEVLGVEQVGAEASFFELGGDSIMSMLLVAAA
                     RRAGLIITARQVFENQTPAALATVVRTADQAAPVGGGEPGVGEIPLTPVMHEILDRAGT
                     DRIGQAAQSTMIVTPADLDFGTLANAVQALVDHHDVLRARLEAEPKPRLVVPETAAAAD
                     WLHRADVRGLDGDALREAVDEQTRAAAARLDPQAGVMAQFVWFDAGPDVQGRLLVTINH
                     LVVDGVSWRILAPDLAEAYMSLAAGREVALQPVPTSFRHWARALAAQAVTPERVAETPE
                     WVGLLRSPDPSFTSRPVDAGRDVGAAVRELAVKVPVDVTSALLTTVPAAFHAGVEDVLL
                     TGLAAAVAEWRRERGETTTGVLLDLEGHGRVPLADGLELSRTVGWFTDSHPVRLDVGAA
                     DHTDLRAGGPAADRAVKRVKEQLRAVPGDGLGFGLLRYLNDETTAELASLPRPQIGFNY
                     LGRSAAGSATDDPAGGERREGPEAREAREARGGRGGPPRLRDWQTTTEGGGDANKDIPV
                     MHPLEVMGVVHDLPEGPQLSLVMLWPAELMPETAVRALAEGWAGMLAGLAAHASAGGSG
                     GHTPSDFPLVEISQGDLDEFEAAAAELAEGE"
     aSDomain        complement(1631..1690)
                     /aSDomain="NRPS-COM_Cterm"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_F5972_RS36645_NRPS-COM_Cterm.1"
                     /evalue="8.60E-09"
                     /label="F5972_RS36645_NRPS-COM_Cterm.1"
                     /locus_tag="F5972_RS36645"
                     /protein_end="1956"
                     /protein_start="1936"
                     /score="27.0"
                     /tool="antismash"
                     /translation="PSDFPLVEISQGDLDEFEAA"
     aSDomain        complement(1643..2197)
                     /aSDomain="TIGR01720"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_F5972_RS36645_TIGR01720.1"
                     /evalue="6.40E-37"
                     /label="F5972_RS36645_TIGR01720.1"
                     /locus_tag="F5972_RS36645"
                     /protein_end="1952"
                     /protein_start="1767"
                     /score="118.7"
                     /tool="antismash"
                     /translation="ADRAVKRVKEQLRAVPGDGLGFGLLRYLNDETTAELASLPRPQIG
                     FNYLGRSAAGSATDDPAGGERREGPEAREAREARGGRGGPPRLRDWQTTTEGGGDANKD
                     IPVMHPLEVMGVVHDLPEGPQLSLVMLWPAELMPETAVRALAEGWAGMLAGLAAHASAG
                     GSGGHTPSDFPLVEISQGDLDE"
     aSModule        complement(1643..6610)
                     /complete
                     /domains="nrpspksdomains_F5972_RS36645_Condensation_LCL.1"
                     /domains="nrpspksdomains_F5972_RS36645_AMP-binding.1"
                     /domains="nrpspksdomains_F5972_RS36645_PCP.2"
                     /domains="nrpspksdomains_F5972_RS36645_Epimerization.1"
                     /domains="nrpspksdomains_F5972_RS36645_TIGR01720.1"
                     /locus_tags="F5972_RS36645"
                     /monomer_pairings="Dhpg -> D-Dhpg"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       complement(2114..2176)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_F5972_RS36645_0021"
                     /evalue="1.50E-10"
                     /label="NRPS-E6"
                     /locus_tag="F5972_RS36645"
                     /protein_end="1795"
                     /protein_start="1774"
                     /score="33.2"
                     /tool="antismash"
                     /translation="VKEQLRAVPGDGLGFGLLRYL"
     aSDomain        complement(2237..3172)
                     /aSDomain="Epimerization"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_F5972_RS36645_Epimerization.1"
                     /evalue="1.10E-127"
                     /label="F5972_RS36645_Epimerization.1"
                     /locus_tag="F5972_RS36645"
                     /protein_end="1754"
                     /protein_start="1442"
                     /score="418.7"
                     /specificity="E activity: active"
                     /specificity="Active site motif: NHLVVDG"
                     /tool="antismash"
                     /translation="VGEIPLTPVMHEILDRAGTDRIGQAAQSTMIVTPADLDFGTLANA
                     VQALVDHHDVLRARLEAEPKPRLVVPETAAAADWLHRADVRGLDGDALREAVDEQTRAA
                     AARLDPQAGVMAQFVWFDAGPDVQGRLLVTINHLVVDGVSWRILAPDLAEAYMSLAAGR
                     EVALQPVPTSFRHWARALAAQAVTPERVAETPEWVGLLRSPDPSFTSRPVDAGRDVGAA
                     VRELAVKVPVDVTSALLTTVPAAFHAGVEDVLLTGLAAAVAEWRRERGETTTGVLLDLE
                     GHGRVPLADGLELSRTVGWFTDSHPVRLDVG"
     CDS_motif       complement(2246..2293)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_F5972_RS36645_0020"
                     /evalue="6.70E-07"
                     /label="NRPS-E5"
                     /locus_tag="F5972_RS36645"
                     /protein_end="1751"
                     /protein_start="1735"
                     /score="21.6"
                     /tool="antismash"
                     /translation="LSRTVGWFTDSHPVRL"
     CDS_motif       complement(2717..2782)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_F5972_RS36645_0019"
                     /evalue="2.00E-10"
                     /label="NRPS-E2"
                     /locus_tag="F5972_RS36645"
                     /protein_end="1594"
                     /protein_start="1572"
                     /score="32.9"
                     /tool="antismash"
                     /translation="LLVTINHLVVDGVSWRILAPDL"
     CDS_motif       complement(2996..3067)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_F5972_RS36645_0018"
                     /evalue="3.80E-05"
                     /label="C2_LCL_024-062"
                     /locus_tag="F5972_RS36645"
                     /protein_end="1501"
                     /protein_start="1477"
                     /score="16.1"
                     /tool="antismash"
                     /translation="DLDFGTLANAVQALVDHHDVLRAR"
     aSDomain        complement(3212..3412)
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_F5972_RS36645_PCP.2"
                     /evalue="2.00E-21"
                     /label="F5972_RS36645_PCP.2"
                     /locus_tag="F5972_RS36645"
                     /protein_end="1429"
                     /protein_start="1362"
                     /score="68.0"
                     /tool="antismash"
                     /translation="EEILCGLFAEVLGVEQVGAEASFFELGGDSIMSMLLVAAARRAGL
                     IITARQVFENQTPAALATVVRT"
     CDS_motif       complement(3320..3349)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_F5972_RS36645_0017"
                     /evalue="1.40E-01"
                     /label="PCP_mE"
                     /locus_tag="F5972_RS36645"
                     /protein_end="1393"
                     /protein_start="1383"
                     /score="5.6"
                     /tool="antismash"
                     /translation="SFFELGGDSI"
     CDS_motif       complement(3458..3484)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_F5972_RS36645_0016"
                     /evalue="5.80E-01"
                     /label="NRPS-A_a10"
                     /locus_tag="F5972_RS36645"
                     /protein_end="1347"
                     /protein_start="1338"
                     /score="3.7"
                     /tool="antismash"
                     /translation="GKLDRAALP"
     CDS_motif       complement(3881..3946)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_F5972_RS36645_0015"
                     /evalue="6.20E-12"
                     /label="NRPS-A_a8"
                     /locus_tag="F5972_RS36645"
                     /protein_end="1206"
                     /protein_start="1184"
                     /score="37.4"
                     /tool="antismash"
                     /translation="FVGRADEQVKIRGFRIEPGEVE"
     aSDomain        complement(3911..5188)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_F5972_RS36645_AMP-binding.1"
                     /evalue="9.60E-105"
                     /label="F5972_RS36645_AMP-binding.1"
                     /locus_tag="F5972_RS36645"
                     /protein_end="1196"
                     /protein_start="770"
                     /score="342.4"
                     /specificity="substrate consensus: Dhpg"
                     /tool="antismash"
                     /translation="FEEQADRAPDAVAVWCDGNGVSYREVEDAANQLASYLRELGVGAE
                     SRVGLVLPRGVQLVVSILAAWKAGAGYVPIDPAYPADRIGFILADSAAQVVIGTTATLS
                     GITTPETGTDANAETGASATASVGANSAAAETLTGAGGLRVVVLDDERTAERIDAQSAE
                     RFDVAVEASGLAYVIYTSGSTGRPKGVAVPHAGVANLAHAMRPALDVGPGVTALQFASF
                     GFDAAVLDVAVTLAAGGTLAIATEAERAEPEALARMIGAAGVEVASVVPSLLSVLDPEA
                     VPGVRRWVLGAERLSARLAARWVGSGAEVWNTYGPTEASVITTASPIATPVEQDPAIGA
                     PLPNTAVFVLDDFLQPVPPGVTGELYIAGAGLARGYVGRPGMTGERFVACPFADGVRMY
                     RSGDLARWLNDGQLAFVGRADEQVKIR"
     CDS_motif       complement(4028..4117)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_F5972_RS36645_0014"
                     /evalue="6.30E-15"
                     /label="NRPS-A_a6"
                     /locus_tag="F5972_RS36645"
                     /protein_end="1157"
                     /protein_start="1127"
                     /score="47.3"
                     /tool="antismash"
                     /translation="PPGVTGELYIAGAGLARGYVGRPGMTGERF"
     CDS_motif       complement(4607..4666)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_F5972_RS36645_0013"
                     /evalue="2.20E-10"
                     /label="NRPS-A_a3"
                     /locus_tag="F5972_RS36645"
                     /protein_end="964"
                     /protein_start="944"
                     /score="32.3"
                     /tool="antismash"
                     /translation="AYVIYTSGSTGRPKGVAVPH"
     CDS_motif       complement(4733..4762)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_F5972_RS36645_0012"
                     /evalue="2.10E+00"
                     /label="Cy2"
                     /locus_tag="F5972_RS36645"
                     /protein_end="922"
                     /protein_start="912"
                     /score="1.5"
                     /tool="antismash"
                     /translation="LRVVVLDDER"
     CDS_motif       complement(4961..5002)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_F5972_RS36645_0011"
                     /evalue="1.60E-04"
                     /label="NRPS-A_a2"
                     /locus_tag="F5972_RS36645"
                     /protein_end="846"
                     /protein_start="832"
                     /score="15.0"
                     /tool="antismash"
                     /translation="LAAWKAGAGYVPID"
     CDS_motif       complement(5546..5662)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_F5972_RS36645_0010"
                     /evalue="4.20E-24"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="F5972_RS36645"
                     /protein_end="651"
                     /protein_start="612"
                     /score="77.1"
                     /tool="antismash"
                     /translation="RETDLAAYAHQDVPFERLVDELNPTRSLSRNPLFQIMLA"
     aSDomain        complement(5702..6610)
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_F5972_RS36645_Condensation_LCL.1
                     "
                     /domain_subtypes="Condensation_LCL"
                     /evalue="8.90E-112"
                     /label="F5972_RS36645_Condensation_LCL.1"
                     /locus_tag="F5972_RS36645"
                     /protein_end="599"
                     /protein_start="296"
                     /score="364.9"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHIAVDG"
                     /tool="antismash"
                     /translation="EALPLSYAQQRMWFLSRLEEVGGGANYNLPLALRLSGDLDITALE
                     AAVGDVADRHESLRTIFPETDGVPRQHILDGPAGRPPLVVVETTSDQAGEVLAAQSSRG
                     FDLSVELPWRVRLLVTGPSEYVLLIVAHHIAVDGWSMGVLGRDLSTAYAARREGRAPEW
                     RPLPVQYADYALWQREVLGDLDDPGSLISGQLGYWRQALEGAPEELALPADRPRPAASS
                     FRGGNVHLEVDAETHARLVELAQGGNATMFMVAHAALAVLLAKVGAGTDIPIGTAIAGR
                     GDAALEDLAGFFVNTLVLRADL"
     CDS_motif       complement(5711..5800)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_F5972_RS36645_0009"
                     /evalue="1.10E-13"
                     /label="C5_LCL_267-296"
                     /locus_tag="F5972_RS36645"
                     /protein_end="596"
                     /protein_start="566"
                     /score="43.5"
                     /tool="antismash"
                     /translation="DIPIGTAIAGRGDAALEDLAGFFVNTLVLR"
     CDS_motif       complement(6068..6106)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_F5972_RS36645_0008"
                     /evalue="4.10E-06"
                     /label="C4_LCL_164-176"
                     /locus_tag="F5972_RS36645"
                     /protein_end="477"
                     /protein_start="464"
                     /score="19.2"
                     /tool="antismash"
                     /translation="QYADYALWQREVL"
     CDS_motif       complement(6155..6217)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_F5972_RS36645_0007"
                     /evalue="3.50E-11"
                     /label="C3_LCL_132-143"
                     /locus_tag="F5972_RS36645"
                     /protein_end="448"
                     /protein_start="427"
                     /score="35.5"
                     /tool="antismash"
                     /translation="HHIAVDGWSMGVLGRDLSTAY"
     CDS_motif       complement(6422..6538)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_F5972_RS36645_0006"
                     /evalue="6.40E-18"
                     /label="C2_LCL_024-062"
                     /locus_tag="F5972_RS36645"
                     /protein_end="359"
                     /protein_start="320"
                     /score="57.1"
                     /tool="antismash"
                     /translation="ANYNLPLALRLSGDLDITALEAAVGDVADRHESLRTIFP"
     CDS_motif       complement(6566..6595)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_F5972_RS36645_0005"
                     /evalue="4.00E-03"
                     /label="C1_LCL_004-017"
                     /locus_tag="F5972_RS36645"
                     /protein_end="311"
                     /protein_start="301"
                     /score="9.8"
                     /tool="antismash"
                     /translation="SYAQQRMWFL"
     aSDomain        complement(6653..6856)
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_F5972_RS36645_PCP.1"
                     /evalue="1.10E-24"
                     /label="F5972_RS36645_PCP.1"
                     /locus_tag="F5972_RS36645"
                     /protein_end="282"
                     /protein_start="214"
                     /score="78.4"
                     /tool="antismash"
                     /translation="EEVLCGLFAEILGVEEIGTDASFFDLGGDSLRAMRLLARIRSVLN
                     AEVSIRGLFAEPTVAGVARLIDG"
     CDS_motif       complement(6764..6793)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_F5972_RS36645_0004"
                     /evalue="7.80E-01"
                     /label="PCP_mE"
                     /locus_tag="F5972_RS36645"
                     /protein_end="245"
                     /protein_start="235"
                     /score="3.6"
                     /tool="antismash"
                     /translation="SFFDLGGDSL"
     CDS_motif       complement(6818..6850)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_F5972_RS36645_0003"
                     /evalue="5.40E-01"
                     /label="Cy4"
                     /locus_tag="F5972_RS36645"
                     /protein_end="227"
                     /protein_start="216"
                     /score="3.6"
                     /tool="antismash"
                     /translation="VLCGLFAEILG"
     CDS_motif       complement(6917..6943)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_F5972_RS36645_0002"
                     /evalue="4.30E-01"
                     /label="NRPS-A_a10"
                     /locus_tag="F5972_RS36645"
                     /protein_end="194"
                     /protein_start="185"
                     /score="4.0"
                     /tool="antismash"
                     /translation="GKVDRAALP"
     CDS_motif       complement(7400..7465)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_F5972_RS36645_0001"
                     /evalue="6.70E-12"
                     /label="NRPS-A_a8"
                     /locus_tag="F5972_RS36645"
                     /protein_end="33"
                     /protein_start="11"
                     /score="37.3"
                     /tool="antismash"
                     /translation="FAGRADEQVKIRGFRIEPGEIE"
ORIGIN
        1 cgaccgctcc atcaccaccc cgacccgaac accccggccc accccccgag ccagcaaccc
       61 acacgccacc cgatccgaaa cccgagccaa ctccgcgtag gtccacacca ccccaccgtc
      121 gggcagcgca tccgacaccg cctccgacac ggccaccgcg tccggagtcc gccctgcctg
      181 cgccccgaac agctccacca gcgaacccgc acccaccaca cgcgccgtgt cgttccactc
      241 ctccaccacc acccgccgct cggcctcgcc caggacgtcg agctgggcga tcctggctcc
      301 gggatcggcc gccatctggt cgagcagccg cagcatgcgg tccatgagcg cctgggcgct
      361 gctctcgtcg aagaagtccg gacggtaggt cagccgcatc ttcagcccgc cgagcgagcc
      421 ggcgaccagg cccaggggat agttgatcga ctcccggagc ccgttctcgg tgaacttcag
      481 ccctcccggc cccgccggac gcgaggcgcc gtcggcgggc ggcttgttgc cgccggagcc
      541 ggaggggaag ttctcgaagg ccagcgcggt gtcgaaggtc gcgcccggcc ccgccagccg
      601 ctggatgtcg ctgggactca gatattgggc gtccatcaac gccgactgct gtgcctggag
      661 ccgggtcagc gtctccgcga ccgtacgcga gggatcgagc gggacgcgta ccggaatggt
      721 gttgatgaac aggccgagca tgctctccac gccgggcagg tccatcggac ggccggccac
      781 gacggagccg aagacgacgt cgcgccggcc ggtcagcttg cccagcagca ccgcccacgc
      841 ggtctgcacc accgtgttca gcgtcacgcc gtgggagcgg gtcagttcct gcagcgcctg
      901 gtccagctcg gcgctcgcct ccccggtcag gctgtcgcag tggccggggg tggcgtcgcg
      961 cgccgccggg gcgaccagcg tcggcccctc cacgtcgctc agcgcctgcc gccacgcctc
     1021 cctggccgcg tccttgtcct ggcgggcgag ccactccagg tagtgccggt acggggtcac
     1081 cggaggcagt ccctcggccg tgccgcccgc ctcgtacgac cgccacagct cgcccatgag
     1141 gatcggcagc gaccagccgt cgaccaggat gtggtggagt gtgaccatca tccggtatcg
     1201 gctgggggcc accttcgcca ggagcacctt cagcagcggc ggcaccgcca ggtcgaaccg
     1261 ctcggcccgc tcctcgatgc cgatccgctc cgactcggcc cacgcctcgt cctcgggcag
     1321 ctccgacagg tccacctcgc gccacggcag ggtcacccgc ctcatgatca gctgtacggg
     1381 ggctcccgag ctgcggctgc ggaacccggc gcgcaggctc tcgtggcggt cgagcagggc
     1441 ctgccaggac gcccgcagcc gcgccgcgtc cagctcgccc tccaacccga tgatcatctg
     1501 ctcgacgtac acgtcggcgt tctgctcgtc gaacagggag tggaagagca tgccctcctg
     1561 gagaggggac agcggccaca ctcccgcaag cgcggattcc ttcatgtcat tccccttccg
     1621 caagctccgc cgcggcggct tcgaactcgt ccaggtcgcc ttggctgatc tccaccaggg
     1681 ggaagtcgga gggcgtgtga cccccgctgc cgccggcgga ggcatgagcg gcgaggccgg
     1741 ccagcatccc ggcccagccc tccgccaggg cgcgtacggc cgtctccggc atgagctccg
     1801 ccggccacag catgaccagc gagagctggg gaccctccgg caggtcgtgg accaccccca
     1861 tgacctccaa ggggtgcatg acggggatgt ccttgttggc atcgccgccg ccctcggtgg
     1921 tcgtctgcca gtccctcagc cggggtggtc ctccgcggcc tccccgggct tcccgggctt
     1981 cccgggcttc agggccttcc cggcgctcgc cgcccgccgg gtcgtcggtc gcggacccgg
     2041 ccgccgacct gcccaggtag ttgaagccga tctgcggcct cggaagcgag gcgagctcgg
     2101 cggtggtctc gtcgttgaga tagcggagga ggccgaatcc caggccgtct ccggggactg
     2161 cccgcagctg ctccttgacc cgcttgaccg cccggtccgc ggcagggccg cccgcccgca
     2221 gatcggtgtg gtcggccgcg ccgacgtcga gccgtacggg atggctgtcg gtgaaccagc
     2281 ccaccgtgcg ggagagctcc agaccgtcgg ccagggggac gcggccgtgg ccctccagat
     2341 cgagcaggac gccggtcgtg gtctcgccgc gctcgcgccg ccattcggcg acggccgccg
     2401 cgagaccggt cagcagcacg tcctcgaccc ccgcgtggaa cgcggcggga acggtggtaa
     2461 gcagcgccga ggtgacgtcg accggcacct tcaccgccag ctcgcgcacc gccgcgccga
     2521 cgtccctgcc ggcatccacc ggccgggagg tgaacgatgg gtcgggactc cgcaggagcc
     2581 ccacccattc aggtgtttca gccacccgtt cgggagtgac ggcctgtgcg gccagcgccc
     2641 gcgcccagtg ccggaacgag gtcggcaccg gctggagcgc gacctccctg cccgcggcca
     2701 gcgacatgta cgcctcggcc aggtccggcg ccaggatccg ccaggagacc ccgtcgacca
     2761 ccaggtggtt gatggtgacc aggagacgtc cctgcacgtc cggtcccgcg tcgaaccaga
     2821 cgaactgggc catcaccccc gcctgcggat ccagtcgtgc ggccgccgcc cgggtctgct
     2881 cgtccaccgc ctcgcgcagc gcgtcaccgt cgagtccgcg tacgtcggcc cggtgcagcc
     2941 aatcggccgc cgcagccgtc tccggcacca ccagacgcgg tttcggctcg gcctccagcc
     3001 gggcgcgcag cacgtcgtgg tggtccacca gcgcctgaac cgcgttcgcc agcgtgccga
     3061 agtcgagatc ggccggtgtg acgatcatcg tcgactgcgc ggcctggccg atccggtccg
     3121 ttcccgcccg gtccaggatc tcgtgcatca ccggcgtcag cgggatctct ccgacgcccg
     3181 gctcgccgcc gcccaccgga gcggcctggt cggccgtacg gacgacagtg gcgagcgcgg
     3241 ccggggtctg gttctcgaag acctgacgcg cggtgatgat cagtccggcg cggcgggcgg
     3301 cggcgaccag cagcatcgac atgatggagt cgccgcccag ctcgaagaac gacgcctccg
     3361 cgccgacctg ctccacgccc agaacctcgg cgaacagtcc gcagaggatc tcttccatcg
     3421 gggtttccgc ggcccgcccc gcatcgggca gatcaggcgc cggtagggca gcccggtcca
     3481 gcttgccgtt gaccgtcagc ggaatcgcct cgatttgaac gaccagcgga accatgtaat
     3541 ccggcaaccg cgacgccgcg aactcccgca acgccgcgat atccacccgc gcggcgaccg
     3601 ccccgccatc ggccgggctc gcggcgtccg gaccggtgac atccatgccc gtcccgctcg
     3661 gggaaccctc ctcgcccagc gcgccggagc ctgcgacgtc tgggctggca gcacccgaac
     3721 tcgcagtacc cgcgctcgcg gtggccgggc tgatgacggt gggggcttgt gcgtccgggt
     3781 tcagggcggg gacgacgtag gcgaccaggc gtttgtctcc ggggcggtcc tcgcgaacga
     3841 tgacggcgac ctgggtcacg gactcgtggc tcgcgaggac ggcttcgacc tctccgggtt
     3901 cgatacggaa cccgcggatc ttcacctgct catccgcgcg gccgacgaat gccaactggc
     3961 cgtcgttgag ccagcgggcc aggtcgccgc tgcggtacat ccgcaccccg tccgcgaacg
     4021 ggcaggcgac gaaccgctcg ccagtcatcc ccggacggcc cacatacccc cgggccagac
     4081 ccgcgccggc gatgtacagc tccccggtca ccccgggcgg gaccggctgg aggaagtcgt
     4141 ccagcacgaa cacggcggtg ttggggagcg gcgcaccgat cgccgggtcc tgctccaccg
     4201 gagtcgctat cgggcttgcg gtggtgatca cactggcctc ggtcgggccg taggtgttcc
     4261 acacctccgc ccccgacccc acccacctcg ccgctaggcg ggcgctcaac cgctcggcac
     4321 ccagcaccca ccgacgcacc cccggcacgg cctccgggtc cagcacactc agcagagacg
     4381 gcaccacact cgccacctcg acacccgccg cgccgatcat gcgggcgagc gcctccggtt
     4441 cggcccgctc ggcctccgtc gcgatcgcca gcgttccccc cgccgccaaa gtgacggcga
     4501 catccagcac ggcggcgtcg aacccgaagg aggcgaactg caacgccgtc acccccgggc
     4561 ccacgtcgag ggccggccgc atcgcatgcg cgaggttcgc caccccggca tgcggcaccg
     4621 ccaccccctt cggccgcccc gtcgaccccg aggtgtaaat cacatacgcc aaccccgacg
     4681 cctcgacagc cacatcgaaa cgctccgccg attgcgcatc gatacgctca gccgtgcgct
     4741 cgtcatccag cacgaccaca cgcaacccac ccgcacctgt gagggtttcg gcagctgcgc
     4801 tgttcgcacc cacgctggcg gtcgcacttg cacccgtctc cgcattggcg tcggtgccgg
     4861 tctcgggcgt tgtgatgccg gacagggtgg cggtggtgcc gatgacgacc tgggcggcgc
     4921 tgtcggccag gatgaatccg atccggtcgg cggggtaagc ggggtcgatc ggcacgtatc
     4981 ccgccccggc cttccaggcc gccaggatcg acacgaccaa ctgaaccccg cgcggcagca
     5041 ccagccccac ccgggactcc gcgccaaccc ccaactcgcg caggtaggag gcgagctggt
     5101 tggcggcgtc ctccacctcc cggtaggaga cgccgtttcc gtcgcaccag accgccaccg
     5161 catccggtgc gcgatcggcc tgctcctcga accggtccag caccgtcccg accaccaccg
     5221 gggtggcggt ggcgttccac tcctccacca ccgaccgccg ctcggactcc tccagcacat
     5281 cgacctggct gagccgcagc gacgagtcgg aggcgacctg ctccagcacg cgcaccaacc
     5341 gccgcgcgag cgcctgagca gtggactcgt cgaacagatc ggcggcgtac aggacaccgc
     5401 cgcccagccc ggccggagcc ccggcctcgt cccggcgctc caccagcgtc accgacagat
     5461 cgaaccgggc gacttcttcg gaagagggct gtgccgagga cacctggaga gccggcaggt
     5521 tccacgtggg cggtgtggcg ttctgcacgg ccagcatgat ctggaagagc gggttccggg
     5581 acagggaacg agtggggttg agctcgtcca cgaggcgttc gaaggggacg tcctggtggg
     5641 cgtaggcggc caggtcggtc tcgcgcaccc gcgccagcac gtcttcgaac gacgggtcgc
     5701 cggacaggtc ggcgcgaagg acgagggtgt tgacgaagaa cccggccaga tcctccagcg
     5761 ccgcgtcccc gcgaccggcg atcgccgtac cgatcgggat gtcggtcccc gcgcccacct
     5821 tcgccagcag caccgccagc gccgcgtgcg ccaccatgaa catcgtcgcg ttaccgccct
     5881 gcgccagctc caccagccgg gcgtgggtct ccgcgtccac ctccagatgc acgttgccgc
     5941 cgcggaacga cgacgccgcc ggacgcggcc gatcggccgg aagcgccagc tcctccggcg
     6001 cgccttccaa ggcctgacgc cagtaaccga gctggccgct gatcaggctg cccggatcgt
     6061 ccaggtcgcc caggacctct cgctgccaca gcgcgtagtc cgcgtactgc accggcagcg
     6121 gccgccactc cggcgcgcgt ccctcgcgac gggccgcgta cgccgtgctc aggtcccggc
     6181 ccagcacccc catcgaccag ccgtccaccg cgatgtgatg tgccacgatc agcagcacat
     6241 actccgaagg acccgtcacc agcagccgca cccgccaggg cagctcgacg ctcaagtcga
     6301 agccgcggct tgattgggcg gccagcacct ccccggcctg atcggaggtg gtctcgacaa
     6361 ccaccagcgg tggcctgccg gccggcccgt ccaggatgtg ctggcggggt acgccatcgg
     6421 tctcggggaa gatcgtgcgc aggctctcgt ggcggtcggc gacgtcaccg acggccgcct
     6481 ccagggccgt tatgtccaga tcacccgaca ggcgcagggc cagtggcagg ttgtagttcg
     6541 cacctccgcc gacttcctcc agccggctga ggaaccacat ccgctgctgg gcgtacgaca
     6601 gcggcagcgc ctccggccgt ggcatcggcg tcaacgcccg acgggtctca cccgagccgt
     6661 cgatgagccg ggccactccg gcgacggtcg gctcggcgaa cagcccgcgg atgctgacct
     6721 cggcgttcag caccgaccgg attcgggcca gcagccgcat ggcccgcagg gagtcgccgc
     6781 cgaggtcgaa gaaggaggcg tccgtgccga tctcctccac cccgaggatc tcggcgaaca
     6841 gcccgcagag cacctcttcg gtgggagtgg ccggggcacg accgccggcc gacccggcca
     6901 gaccggccag gtccggcgcg ggcaacgcgg cccggtccac cttcccgttc gccgtgaccg
     6961 gcagccgctc cagcaccacc accgccgacg gcaccatgta ctccggcaac cgcgcggcga
     7021 catggtcccg caccccagcc gtatccacgc tgccgccgct gccactgccg ctcctgctgt
     7081 tcccaccccc gccgcctcca ccgctcacga cgaggccgct gccgtcgccg cttgcacggc
     7141 tttcggcggt gtcgtctctg gcggcagtgc cgatccctcc ggcatcgtcg ctgctcccgg
     7201 cagagtcgcc actgccgacg gcgccgctgc ttccgacggc gccgctgctt ccgacggtgc
     7261 cgctgccgtc gctggtgtcg ccgctttcga tggtgttttc ggtggtgggg acgatgtagg
     7321 cgattaggcg cttgtcgccc gggcggtcct cgcgggcgac caccacggcc tgtgcgacgg
     7381 attcatggct cgccaggacg gcttcgatct cgccgggttc gatgcggaac ccgcggatct
     7441 tcacctgctc atcggcccgg cccgcgaaga ccagctgccc gtcaccccgc caacgggcca
     7501 g
//
