LOCUS       NZ_VYTZ01000014        25201 bp    DNA     linear   CON 20-NOV-2024
DEFINITION  Microbispora cellulosiformans strain Gxj-6 Scaffold14, whole genome
            shotgun sequence.
ACCESSION   NZ_VYTZ01000014
VERSION     NZ_VYTZ01000014.1
KEYWORDS    WGS; RefSeq.
SOURCE      Microbispora cellulosiformans
  ORGANISM  Microbispora cellulosiformans
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Streptosporangiales; Streptosporangiaceae; Microbispora.
REFERENCE   1  (bases 1 to 197692)
  AUTHORS   Gong,X.
  TITLE     Screening of Novel Bioactive Compounds from Soil-Associated
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 197692)
  AUTHORS   Gong,X.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-SEP-2019) College of Land and Environment, Shenyang
            Agricultural University, No. 120, Dongling Road, Shenhe District,
            Shenyang, Liao Ning 110866, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 2.04 OR JUL-2018
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 400x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_008728085.1-RS_2024_11_18
            Annotation Date                   :: 11/18/2024 02:05:44
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,471
            CDSs (total)                      :: 7,401
            Genes (coding)                    :: 7,312
            CDSs (with protein)               :: 7,312
            Genes (RNA)                       :: 70
            rRNAs                             :: 5, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 1 (5S, 16S)
            partial rRNAs                     :: 3, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 89
            CDSs (without protein)            :: 89
            Pseudo Genes (ambiguous residues) :: 0 of 89
            Pseudo Genes (frameshifted)       :: 7 of 89
            Pseudo Genes (incomplete)         :: 80 of 89
            Pseudo Genes (internal stop)      :: 8 of 89
            Pseudo Genes (multiple problems)  :: 6 of 89
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 09:06:26
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 158028
            Orig. end                         :: 183229
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            VYTZ01000014.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..25201
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="2"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..25201
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25201
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:15201](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..15201)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    253..266
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.84"
                     /tool="antismash"
     gene            complement(293..967)
                     /locus_tag="F5972_RS30120"
                     /old_locus_tag="F5972_30125"
     CDS             complement(293..967)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012694.5"
                     /locus_tag="F5972_RS30120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F5972_30125"
                     /product="type II secretion system F family protein"
                     /protein_id="WP_191910382.1"
                     /transl_table=11
                     /translation="MLTWWFTGWPIAALGAAVGAVTLPRMLSARDSGRRIERLEALQTW
                     TRHLADVLGGSAGIEEALQSSADNPPPAIAPEVRALARRLAYRTPTEHALRAFADDLND
                     PTGDVIAAALILACRARGKGLREVLQGLARTVAKDVAARREIDAERATHRTTARWVIGA
                     LLGYTAFALVNRAYVAPFGTVGGQLVLGIVIALYAGAFMWLHRLTRAPKGHRFLNPAGD
                     PS"
     gene            complement(1123..2436)
                     /locus_tag="F5972_RS30125"
                     /old_locus_tag="F5972_30130"
     CDS             complement(1123..2436)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012652.5"
                     /locus_tag="F5972_RS30125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F5972_30130"
                     /product="CpaF family protein"
                     /protein_id="WP_150938328.1"
                     /transl_table=11
                     /translation="MSFEVQQAVREVLPTVTQALDAAAVNGDEAVREYARAVITDLVRE
                     HVDSRALAGRDAPTLQEERRLAEAVYNEIFALGRLQPFVDDPEVENIDVNGCDQVWITY
                     RDGRKALGPPIADSDEELVGNVRRWAAYQGQTARDFSIARPRLHLSVGHRTRIAALMGV
                     TPRPCLSIRRHGLLEADLDDLMVNGTVDKGLRAFLAAAVRAHKDIVITGGMGDGKTTFA
                     RALAAEIDPDERIATVEKEYELFLHLQTDRHRDVLAMEAREGNTEGLGAITMRQLIEDA
                     LRFNARRIIVGEVRGDELVPMLEAMNTGGSGSICTMHADSADQVFARMLILAGSGGLSI
                     APDTLFRTIGMAVDFVVHLRHELRHDIDGTVNRRYVAEVNEVLPPGDGLEPAVNHVYVP
                     GPDGRAVPNTIPQCMEELVAAGFDPDLFAPRGWDRGYA"
     gene            complement(2433..3176)
                     /locus_tag="F5972_RS30130"
                     /old_locus_tag="F5972_30135"
     CDS             complement(2433..3176)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="F5972_RS30130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="F5972_30135"
                     /product="hypothetical protein"
                     /protein_id="WP_150938330.1"
                     /transl_table=11
                     /translation="MLTVLCSGGHSPGVTTTGLALTLAWPREVLFAECDPAGGSVLSGY
                     LVGQPQERGLGEWAVQLRRGADPGATLREQLLHLAGTVSRRILPGLADPAQVASVRQLW
                     VDITKTFTATPGDVIADVGRVGGSDTPTSLLVDADQVLVVARPTLVDLSALAPRLTEIR
                     ALRGRRSGPRALLVGAGPYGRKEVAKTLGVDVVDHLPHDPRAATVLSHGSGNERYVPRS
                     PLIRAARSLADHLCEEPARTEVTVS"
     gene            complement(3183..3833)
                     /locus_tag="F5972_RS30135"
                     /old_locus_tag="F5972_30140"
     CDS             complement(3183..3833)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF020250.5"
                     /locus_tag="F5972_RS30135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F5972_30140"
                     /product="SAF domain-containing protein"
                     /protein_id="WP_079313187.1"
                     /transl_table=11
                     /translation="MLQRSTPSREAGRATHVRPLPSRRSPVMLVVSIALTALGALIAWQ
                     VYGIAGHRTPVLVMARDVPIGQQLQAQDLRTVALGLDSGVRAVEATDKSAVIGRRAAVD
                     LKAGSLLAPAHLTGTLVPAPGQVVVPVALKPSQLPARGIQPGDRVVAAAVAPAISNGQG
                     TPADHQARVDRVGEPDADGLIVVDLVVPAGEGSALARQAADGKIALILQSRAR"
     gene            complement(3838..4656)
                     /locus_tag="F5972_RS30140"
                     /old_locus_tag="F5972_30145"
     CDS             complement(3838..4656)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="F5972_RS30140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="F5972_30145"
                     /product="hypothetical protein"
                     /protein_id="WP_150938332.1"
                     /transl_table=11
                     /translation="MFAYGMTYVLVAGLAIAPLGDGDGDGVGVSSDYTGYIISAKRLPR
                     PGSQTPTGKGSKVRCSYQRWFADGRENGGLEFVDPGSNLSSEPTGKGAYYLVECSDGYR
                     DVVWIKKRRDAVTPEQLARRAYKLIPIAPPTVLTAPPRGQNGLVGLPQWFFLPDGQWAP
                     KSKRLHIGAVWAAATATPERMTISTGDGQTLTCDGPGTAYDITRPADQQSSTCSHTYQH
                     PASAYRVTVSVTWSGTWRGSGGTGGTLPPITKSVTFPIRVIEAQALVTKG"
     gene            complement(4638..5156)
                     /locus_tag="F5972_RS30145"
                     /old_locus_tag="F5972_30150"
     CDS             complement(4638..5156)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="F5972_RS30145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="F5972_30150"
                     /product="hypothetical protein"
                     /protein_id="WP_150938334.1"
                     /transl_table=11
                     /translation="MAMFVVTASAVTACQSSGTAPEPTRTTTPLSPTPTATTSEDAVLA
                     VYRDLYPAGQRAERAYPAERKAILEQVAAQPLLSRMLRGIAALRATHRVTWGQPEHHPF
                     DVRIKGDHATLHDCQDARKGGQADDRTGKRLTHGTSRIHLVATITKGADDTWRVSKVEQ
                     VKEPCSPTA"
     gene            complement(5734..6786)
                     /locus_tag="F5972_RS30155"
                     /old_locus_tag="F5972_30160"
     CDS             complement(5734..6786)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024197.5"
                     /locus_tag="F5972_RS30155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F5972_30160"
                     /product="EcsC family protein"
                     /protein_id="WP_150938337.1"
                     /transl_table=11
                     /translation="MRKDMSNYETRAWFTLLENERKRRNSLRARGASKVALVTKRTGEQ
                     IRKDPGAVKVTELGDETIIKALEGCFKAIFLPAVFSTSLEKRVEKLRRKHQDLGAESPF
                     ESLDLKDLDKGRPMLTIPFIAVLESGAASVRITGARVSTTVRGGTTAGVAVAVVASDAL
                     ISLALLGRAVAEVAVHYGYDPREPEEEEFLMRVLNYGMASSLMTKTATLASLSCLTQMM
                     MRRATWNQLGKEPLVQVILQIFKLLRLPLTKARLANVMPIVGGILVAGLSFNMLYSAIE
                     DATRLYRARYLAEKYGLSWEDWINQPTLVADAAKADPVVDVTAVEIDGLLNEVTAGEEG
                     ANYAPPAEDD"
     gene            complement(6911..7405)
                     /locus_tag="F5972_RS30160"
                     /old_locus_tag="F5972_30165"
     CDS             complement(6911..7405)
                     /EC_number="3.6.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019634613.1"
                     /locus_tag="F5972_RS30160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F5972_30165"
                     /product="NUDIX hydrolase"
                     /protein_id="WP_150938339.1"
                     /transl_table=11
                     /translation="MSDSASYLAFVASVPRLRAAAGALLRDNEGRVLVVHPVYKDEWDI
                     PGGMVEAGESPASALLRELQEELGITPPVGQLACVDWVPPTPPWDAGLMFVFNAGVLTD
                     SQIAALRLQPEELDEYVFAPPADLDKLLPPGLARRMNAAILAADAGQTAYLEDGLICLL
                     P"
     gene            7583..8149
                     /locus_tag="F5972_RS30165"
                     /old_locus_tag="F5972_30170"
     CDS             7583..8149
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017567045.1"
                     /locus_tag="F5972_RS30165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F5972_30170"
                     /product="kinase"
                     /protein_id="WP_225312028.1"
                     /transl_table=11
                     /translation="MIVLRGNSGSGKTSVARAVRVAYGRGLALVGQDVVRRELLRERDV
                     HGGVNIGLIDTIVRYSLDHGYHVLLEGILTASRYGAMLQSLRRDHAGTSAFFYLDVSLP
                     ETLRRHDSRPQRSEFTPDQMREWYQERDLLPDGCETVIGEDSPLEASVRQVLRQARLAP
                     ARPTSDNAAPMTAASVRGDPRDRGQ"
     misc_feature    8267..8281
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.25"
                     /tool="antismash"
     gene            8295..8831
                     /locus_tag="F5972_RS30170"
                     /old_locus_tag="F5972_30175"
     CDS             8295..8831
                     /EC_number="3.6.-.-"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017590026.1"
                     /locus_tag="F5972_RS30170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F5972_30175"
                     /product="NUDIX hydrolase"
                     /protein_id="WP_318527645.1"
                     /transl_table=11
                     /translation="MILADPDQHTLRAAVTDTYRAEAEFDDARAWLEELLGSRSAIEPI
                     AAEVWAFDEALERVLLVKHRWRGWVAPGGKVEQGEIPRDAARRELHEETGIVGDLSDVP
                     AAVFVRSYRSDWAPTLGLAYAAVLNGSLPLSGESHQQAAWVPLHHDWEGAFPEDRPRIR
                     EYARHLARTREGTGR"
     gene            complement(8899..9996)
                     /locus_tag="F5972_RS30175"
                     /old_locus_tag="F5972_30180"
     CDS             complement(8899..9996)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019629313.1"
                     /locus_tag="F5972_RS30175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F5972_30180"
                     /product="hypothetical protein"
                     /protein_id="WP_150938344.1"
                     /transl_table=11
                     /translation="MIPAIASHIPLVRRPKAAGLPLAERISHLTELTVEPTNASHRALV
                     ARASGILNYAALIASDVGMPDLAAQLCWRQHQVFAKAGNLTGDIAVMALMPLVNIARLL
                     IREGDGEGAYDLLTRLYRAAQRRGTAEIRNHNVDLSVLIDTEADHRKVCEELWVTVLID
                     GARALARIGRWTEAAEAMAAHRGVGNRLLDGRQIMIMSLMERGLDEQARATIESTVPAE
                     PWENAIAALLRICCRPATSPAPQPEFEHALQEALALITPPDPATATFQARVGLTALDLA
                     HDRTSPCPALLRDAVVEVSILDAYAARDVLNHRPVYSRLANEQRQKLHAVLTASGLGAG
                     KLSPAHMHALTTAVDTAEVTLRGLL"
     misc_feature    complement(9937..9939)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(10001..12052)
                     /gene="fxlM"
                     /locus_tag="F5972_RS30180"
                     /old_locus_tag="F5972_30185"
     CDS             complement(10001..12052)
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019629314.1"
                     /locus_tag="F5972_RS30180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F5972_30185"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_150938346.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1e-19, bitscore:
                     64.4, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PCMT (E-value: 2.2e-42, bitscore: 138.4,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDVNDKDLPITPEQGWWHASVSFPGGSVSLGAAQALASALHDQRF
                     HFLRKDGGLRLRTERPAADLLDRLVADQVAGGWVGGVYEPESEAFGGPEGMDVAHEVFC
                     ADSRAALAETGRAGARERCILLISAMNRAAGLDPFEIGDVWAKLGSLRPSVTPPAIASR
                     DQAVAAMRRLMNADAARRPDAEPGWAERVAAFEEAGYRLRRLAADGRLTRGLRAVLAHH
                     AIFAFNRAGVSADEQAATAWLGRHVAFADEEAADVSSRTSTSPDSNLTRMETTVTPATD
                     PAELREALVTRLIDSGHLRTPDVIAAFRNTERHLFLPIADLQAAYVDDAVPIKHDETGE
                     MVSCISAPSIVATQLEQLGAKPGHRILEAGAATGYNAHLLGQLVTPGGHVWTVDVDQDL
                     VNGAQKNLAQAGAQDVTVVLADGAAGLPEHAPFDRIQFTVGAGDIPLRILDQLAPNGRL
                     VIPMRIRGSISRSFAFERDGKTWKAVSCEMATFVPLRKGVCDDTYTLVHMAGDGNVRLE
                     TFSEQDVDHEAIRTVLDQPPAKVYSGVQFRQGDPWQWLYLYLACVLPNGLSRMPGSRPG
                     FTPHFGWGSMAALDGDTLAYLTVREGEDDQGRFWEIGVIGHGPRAAELADQVATEIGEW
                     DRGWGNNAPEPDFRMAVGDARDKLTTAEPRFVIDKTYSRLVVDWPRRS"
     gene            complement(12104..13171)
                     /locus_tag="F5972_RS30185"
                     /old_locus_tag="F5972_30190"
     CDS             complement(12104..13171)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019629315.1"
                     /locus_tag="F5972_RS30185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F5972_30190"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_150938348.1"
                     /sec_met_domain="LANC_like (E-value: 6.2e-38, bitscore:
                     123.6, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTATLPRTQDLSEGTLGVALLHIERGDLAFARKTLAQAVAGGVSA
                     GGNASLFHGAPALEFVLSRAGRADRDVRDAVDRVVAARLAAARRRQAREALPHLAEFDL
                     IRGLAGLGALLLTRADASPLLEEVLDYLVSLFRPVRIQGRELPGWWSDAGPADEQMPGG
                     HGNNGVAHGIAGPLAVLSLAARRSIQVPGQHDAIEVFARWLDRYGCCYWITCDQLSDPE
                     PPKPQVARPSWCYGELGIARTRQLAAIALNDPARRLAAEDTVVRALADQARLSRITDAS
                     LCHGWAGLLTVARAVADDSSDPDRYTPLIEDLTNRLAADLDRLSKPGFMEGRAGAQLAL
                     DGTNTTGWARALLIT"
     gene            complement(13168..15201)
                     /locus_tag="F5972_RS30190"
                     /old_locus_tag="F5972_30195"
     CDS             complement(13168..15201)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019629316.1"
                     /locus_tag="F5972_RS30190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F5972_30195"
                     /product="lantibiotic dehydratase family protein"
                     /protein_id="WP_225312029.1"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 2.6e-19,
                     bitscore: 63.0, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_N (E-value: 3e-109, bitscore:
                     359.1, seeds: 73, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRLRHSLYRVAGEGMLRAAVHLTGPDLPPWPGPTAPLERWRSWL
                     AAVWADDAFRQAGSCASPDLDRQVQAILGRLSVKVRRARRAALATARYAIRYARRSTPF
                     GLFAGVALVEFGHVAEVRFGELHQAVARPEPVALDAAVSGWEADGEQVADVDVCVNNLA
                     RQRAGRVYVPSEGASEFSLALTPAVALALDAARVPIRYSTLTDKLAAQFPGTDERHRTG
                     LLAELLRVRLLRSSLRAPATVVDPADALPAALRDTRNRTAALDLRLDATVWLPTTVVTE
                     AETAATVLTRLAMYPTGTPAWRRYIEQFADRYGEGVEVPLELVTDPERGLGFPEGFGQV
                     SEPPRPMTRRDRLLLELAATAAVSGSRSVVLSGAVIERLEGAAGKRTVTPPHLELCVQL
                     QAASTRALDAGDFRLRVFTVSRAAGSMTGRFWHLFPQTGATYAGLPTVEPGAELVQLSF
                     HAGRVSADLLTRAPQVLPRLVSVGEFRHRGKGVLFPSDLAVGLRDGRLYLTEAATGTHV
                     EVLAPTAINFLWNNYTPPLARFLAEISRATTPQVTWFDWGAAWTLPFTPALHYRRSILV
                     PARWKLPTHELPGRTATLDEWTGRLHAWMGRFGLPDRVLLAEDDQHLPLDLRQDMHLDL
                     LRTHLASSPTGVAILYEAPPSDADGWISGRAHSLVVPLRARS"
     aSDomain        complement(14482..14733)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_F5972_RS30190_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="5.00E-20"
                     /identifier="RREFam001.1"
                     /label="F5972_RS30190"
                     /locus_tag="F5972_RS30190"
                     /protein_end="240"
                     /protein_start="156"
                     /score="63.0"
                     /tool="antismash"
                     /translation="VCVNNLARQRAGRVYVPSEGASEFSLALTPAVALALDAARVPIRY
                     STLTDKLAAQFPGTDERHRTGLLAELLRVRLLRSSLRAP"
     misc_feature    complement(15190..15192)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(15284..15466)
                     /locus_tag="F5972_RS30195"
                     /old_locus_tag="F5972_30200"
     CDS             complement(15284..15466)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR04363.1"
                     /locus_tag="F5972_RS30195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F5972_30200"
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_150938350.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 1.3e-17, bitscore:
                     56.8, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTQTITRSAEPRQHASDEADDPFQLDITFIENTPATETVLLCST
                     GDNCGSSCPSACTTS"
     CDS_motif       complement(15353..15466)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MSTQTITRSAEPRQHASDEADDPFQLDITFIENTPATE"
                     /locus_tag="F5972_RS30195_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(15284..15352)
                     /prepeptide="core"
                     /locus_tag="F5972_RS30195_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="-5.30"
                     /molecular_weight="1945.1"
                     /monoisotopic_mass="1943.8"
                     /core_sequence="TVLLCSTGDNCGSSCPSACTTS"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSTQTITRSAEPRQHASDEADDPFQLDITFIENTPATE"
                     /leader_location="[15352:15466](-)"
                     /alternative_weights="1963.2"
                     /alternative_weights="1981.2"
                     /alternative_weights="1999.2"
                     /alternative_weights="2017.2"
                     /alternative_weights="2035.2"
     gene            complement(15651..15905)
                     /locus_tag="F5972_RS30200"
                     /old_locus_tag="F5972_30205"
     CDS             complement(15651..15905)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020542601.1"
                     /locus_tag="F5972_RS30200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F5972_30205"
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_150938352.1"
                     /transl_table=11
                     /translation="MPQPCFALSSVSWRKSSRSANNCACVEVAVLPSGEVGVRDSKNQD
                     GPVLLFTPAEWDAFINGVKDGEFDPERLAANVQAPSLPV"
     gene            complement(16123..16677)
                     /locus_tag="F5972_RS30205"
                     /old_locus_tag="F5972_30210"
     CDS             complement(16123..16677)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024970.5"
                     /locus_tag="F5972_RS30205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F5972_30210"
                     /product="ATP-binding protein"
                     /protein_id="WP_150938354.1"
                     /transl_table=11
                     /translation="MDVLIAPTQTPPPTPEEPVQIPAEDRLIRVSAWQLSREGGPQQAR
                     RLLRSHVAEHVDGPALDEADVVVSELATNAFVHTGGPCELRLVQYAGFPIVYEIADVGD
                     QEDIVAKRLAEALVCPAVADDPDIAHLDEGGFGLSIVAALTKGHCGVRPARLYHSTQAG
                     KGVWFALPALGRRSCGSATSG"
     gene            16943..18373
                     /locus_tag="F5972_RS30210"
                     /old_locus_tag="F5972_30215"
     CDS             16943..18373
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024949.5"
                     /locus_tag="F5972_RS30210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F5972_30215"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_150938358.1"
                     /transl_table=11
                     /translation="MDPSANGDRVCPACRFAKLSRYNPDPLCSPCLTSARESTGVTPTW
                     VWDSLPLRQALARLDMGAVLAIMRGASGLSQLDFGNLLGWSQSVVTKVERRQRYTFHDV
                     REILRVCDELGMPRAALLPLILGREDASLGSDDEAGFWGVDVDLDRREFGAVTSGLVVA
                     ALLPPPERVDRAHVRYLQAVLSRLRTQDRTIGGAGLLRQAMKTFTRVRAMLDESDYTDQ
                     VGRQLLVTTADLGIVTAWLAYDSGNQPLARTLYGQAALLAGSSGDTELIVHVYVNMAQQ
                     ATHLARITGRRGTAREALRFADRAADAARHARSATLHALIALRQALAHAQLDDEVAFRA
                     AICRARNELDRGAHDTDHPWSTFVTQSEIAGYEAMGRIALGDPGRAARLYRSVLGDPAR
                     SPRDRAYYRARLAAATSAAGDHRTAVKEGMQLLPDLGERLTSVRVLNELRPVRHEAEGF
                     DEEFCERFDQAARALALV"
     misc_feature    17420..17422
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            18397..18957
                     /locus_tag="F5972_RS30215"
                     /old_locus_tag="F5972_30220"
     CDS             18397..18957
                     /EC_number="2.3.-.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012792.5"
                     /locus_tag="F5972_RS30215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F5972_30220"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_150938360.1"
                     /transl_table=11
                     /translation="MTEPVIFKRFDAAGAREQREVVSLIHRDAYAERIATGDAFASDQA
                     FMTRFDAYTSRDGFDLVMAYAGDEPVGQAWGWPLPPETRWWNGLEAEPEPGFIVEDGTR
                     TFALSEIMVRRAWTGQGIAHALHDELLAGRGERRATLLVRPDNTTAYAAYVRWGWQPVA
                     RLCPGWPDAPLMDVLILQLPLAQ"
     gene            complement(19337..21094)
                     /locus_tag="F5972_RS30220"
                     /old_locus_tag="F5972_30225"
     CDS             complement(19337..21094)
                     /EC_number="2.7.11.1"
                     /GO_function="GO:0004674 - protein serine/threonine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF019334.5"
                     /locus_tag="F5972_RS30220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F5972_30225"
                     /product="serine/threonine-protein kinase"
                     /protein_id="WP_225312030.1"
                     /sec_met_domain="Pkinase (E-value: 1.1e-44, bitscore:
                     145.9, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MARSELTSIDPKRIGRYRLLAQLGTGGMGRVYLGRARNGPPVAIK
                     VVRPELANDDSFLARFRREATTLLLVGGSFTSRIIEMNLEASPPYLVTEYVDGPSLSDY
                     IAQEGPLEAEATRKIAIGLAEALRSIHTAGVVHRDLKPSNILLSAAGPKVIDFGIAQAL
                     DATSITRTGVVVGSAGYMAPEQFEGRGGPPADVFAWACTVVLAGTGNPPYGSGPLEAVV
                     FRLRNEVPNLDGLPKDLQSIVATALKKEPAERPTADELVRLLIPDSETTTDQTTELTLN
                     LQVKSWTEPLPQWGREQEKRRKRIWLFSGIATAIAVGVGVPVLLHETSQFGGVEPDSKI
                     RQDPSVSPTAQPVVVAAPTAPSKSSPSNTKPTTPLEVARASLAVAEAMGTARFSLKSSG
                     WDEMGFDADGELAFHPPAATRYRMDLSYFGNDENKSSIANITLIGNRGFDTASENPTDA
                     DIGAGVADENLPEPFMTARRVRWASSPFTVQDLVAASSNVKKSVIGGQIFLKGSAPMSK
                     MAKSATVGPLYRFLSTFSKNRSVKFTIVMDQNLAPTRVIQSIPVFEGSDIPITTTYSDW
                     GMPSEPENP"
     misc_feature    complement(20306..20308)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(20762..20764)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    21370..21385
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.6"
                     /tool="antismash"
     misc_feature    21554..21569
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: medium, score: 24.97"
                     /tool="antismash"
     gene            22005..23225
                     /gene="fxlM"
                     /locus_tag="F5972_RS30225"
                     /old_locus_tag="F5972_30230"
     CDS             22005..23225
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR04364.1"
                     /locus_tag="F5972_RS30225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F5972_30230"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_191910383.1"
                     /sec_met_domain="PCMT (E-value: 8.6e-35, bitscore: 113.6,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTADARSPQSADRLRTELVTALREWGSIRSPEVAAAFAKVPRERF
                     APEAPLDAAYSAQDVVVTKRDPDGKATSSISAPWLQAEMLEAARLTRGARVLEIGSGGY
                     NAALIAEIIGPDGFVVTVDIDPWVTERAARFLADTEYPKVKVVLGDAEHAANEYGPFDA
                     ILVTAGAWDCPWGRLLAPEGRMVVPLRFATITRSITFVRDGDRLQGLDPTVCGFIPMQG
                     AGAHKDQEAVLAGGAVKLTIEDGPELDIGALDRALVEPRTELCTGVEVGRGEPFDTLNL
                     WLATVEDRFGMIWQDPDRDRDLVQTALRWYCPALITPHSFAYLTLRDAQPRATAAVHYE
                     LGVYGHGHYGAELALRLHDQIKVWDHAWRHHPEPTFSLYPADATVPNPTVGRIFRKRHT
                     QLVMAWA"
     misc_feature    23547..23563
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 17.75"
                     /tool="antismash"
     misc_feature    23593..23602
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.85"
                     /tool="antismash"
     gene            23943..24686
                     /locus_tag="F5972_RS30230"
                     /old_locus_tag="F5972_30235"
     CDS             23943..24686
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="F5972_RS30230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="F5972_30235"
                     /product="hypothetical protein"
                     /protein_id="WP_225312031.1"
                     /transl_table=11
                     /translation="MARVTSEDWAEIRRLARGYCRTVDATRSRKRMDGSATIVKQGHAP
                     YGTDDVSDDVTQDAVLLFAQRIRDIIASCRTAPEGTAGSPAWVYVRRDGGEMTITRTTL
                     QRWAVRDAAARNGYRIDVPPSEVDATPGAQLMRGLPHAENVSRAAVAFCTAQNSAVIFR
                     QAFGDGQDFPTITDVMEVAGQADDLGRAGVLNKVAQKRYGGAYGSRRNVIRVRDAARAE
                     WRELSERLDDARSAMVHGGTNSAED"
ORIGIN
        1 acgaccggac cagccgtccc gatcccgatc atcgcgccct tctgggtgag gtagtcatcg
       61 gccgtcctgc cgagcaccgc caaatccgcc tgcgggatgc gcgcgccgac tactgttccg
      121 gacagtttcc gcgccatgcg cgaccgccag tccctatccg gctcgctgcg gctcccaccc
      181 ggcctgagcc gttccatcgc cggtgcgagc gcgggcgggg cggggaagag cgccatgatg
      241 gcgagggctc cgccgaggcc gatcaatgcg ccacaggtca gaaccagcgc tatcacgatg
      301 gatcacctgc ggggttgagg aagcgatgtc ccttcggcgc tctggtcagg cggtgcagcc
      361 acatgaaggc acccgcgtac agcgcgatca cgatgccgag cacgagctgg ccgccgaccg
      421 ttccgaacgg ggcgacatag gcccggttga ccagcgcaaa ggccgtgtat ccgagcagcg
      481 cgccgatgac ccatcgggcg gtcgtgcgat gggtggcgcg ctcggcgtcg atctcccggc
      541 gtgcggccac gtccttggcc accgtacggg caaggccctg gagtacctct cgcagtccct
      601 tgccgcgggc gcggcaggcc aggatcagcg ctgcagcgat cacatccccg gtcgggtcgt
      661 tcaggtcatc agcgaacgct cgcaaggcat gctcggtcgg ggtgcgatag gcgagccgcc
      721 gtgccagcgc ccgcacctcg ggggcgatcg ccggcggcgg gttgtccgcg ctggactgca
      781 acgcttcctc gatgcccgcg ctgccgccca gcacgtcggc cagatggcgg gtccacgtct
      841 gaagtgcctc caggcgctcg atccgccgcc cgctgtcgcg ggcgctgagc atccgcggca
      901 gcgtcacagc gcccaccgca gccccgaggg cggcgatcgg ccagcccgta aaccaccacg
      961 tcagcacgag aactcccgca gccgcggtcg cgggaatcgc cggtatccgt ggcagccacc
     1021 gtactgggcg cggaggccga accggggctc ggcgcactcc cgcgatggcg agcagaggtc
     1081 ccgcgacgag tgccgcgccg gccagcgcgg cgagccagcc ggtcatgcgt accctcgatc
     1141 ccagccacga ggcgcgaaca ggtccgggtc gaaccccgcc gccaccagtt cctccatgca
     1201 ctgcgggatc gtgttcggta cggcccgtcc gtccggcccc gggacataga cgtggttgac
     1261 cgccggttcc agtccgtctc ccggcgggag cacctcgttc acctcggcga cgtagcggcg
     1321 gttgaccgtg ccgtcgatgt cgtgacggag ttcgtgccgc aggtggacga cgaagtccac
     1381 ggccatgccg atcgtgcgga aaagcgtgtc cggcgcgatg gaaaggccgc cggaaccggc
     1441 gaggatcagc atccgggcga acacctggtc ggccgagtcg gcatgcatgg tgcagatgga
     1501 gccggagccg ccggtgttca tcgcctccag catcggcacc agctcgtcgc cgcggacctc
     1561 gccgacgatg atccggcgtg cgttgaaccg aagggcgtcc tcgatgagct ggcgcatcgt
     1621 gatcgcgccc agtccttcgg tgttgccctc ccgggcctcc atcgcgagca cgtctcggtg
     1681 ccggtcggtc tgcaggtgaa ggaagagctc gtactccttc tccacggtgg cgatccgctc
     1741 gtccgggtcg atctcggcgg ccagtgcccg ggcgaaggtg gtcttgccgt cgcccatccc
     1801 acccgtgatc acgatgtcct tgtgggcgcg tacggcggcg gcgaggaacg cgcgaagccc
     1861 cttgtccacg gtgccgttca ccatcaggtc gtccaggtcg gcctcgagca ggccgtgtct
     1921 gcggatggac aggcacggcc gcggcgtgac tcccatcagc gcggcaatgc gggtccggtg
     1981 gccgacggac aggtgaagac gcggccgggc gatcgagaaa tcccgggcag tctgtccctg
     2041 gtaggcggcc caccggcgga cgttgcccac cagctcctca tcactgtcgg cgatcggtgg
     2101 tccgagcgcc ttgcgaccgt cccggtaggt gatccacacc tggtcacagc cgttgacgtc
     2161 gatgttctcc acctcggggt cgtcgacgaa cggctgcaga cgccccagcg cgaagatctc
     2221 gttgtagacc gcttccgcga gccggcgctc ctcctgcagc gtcggcgcat ccctgcctgc
     2281 cagcgccctg ctgtccacgt gctcacggac caggtcggtg attactgctc tcgcgtactc
     2341 gcgtacggcc tcgtccccgt tgaccgctgc agcatcaagc gcctgcgtga ccgtgggcag
     2401 gacctcgcgt accgcctgct ggacctcgaa gctcacgaga ctgtcacctc ggtacgtgcc
     2461 ggttcctcac agaggtgatc ggccagcgaa cgagcggccc gaatcagtgg agaacggggg
     2521 acgtatcgct cgttgccgct gccgtgcgac agcaccgtgg cggcccgcgg atcgtgggga
     2581 aggtggtcga ccacatccac gccgagcgtc ttcgccacct ccttgcggcc gtacggcccg
     2641 gccccgacga gcagagcccg cggaccggac cgacgaccgc gcagggctcg aatctcagtt
     2701 aggcggggag ccagcgcgga cagatccacg agcgtgggac gtgcgaccac gagcacctgg
     2761 tccgcgtcga cgagcagcga ggtaggcgtg tccgagccgc cgacgcgtcc gacgtcggcg
     2821 atcacatccc cgggcgtcgc ggtgaaggtc ttggtgatgt ccacccagag ttgccggacc
     2881 gaggccacct gagcagggtc ggcgaggcct ggcaggatac ggcgggatac ggtcccggcc
     2941 agatgcaaga gctgctcgcg aagcgtggcg ccggggtcgg cgccgcggcg gagttggacc
     3001 gcccactcgc ccaggccgcg ttcctgcggt tggccgacca gatatccgga caggacgctg
     3061 ccaccagcag gatcgcactc ggcgaacaga acctcacgcg gccaggccag cgtgagagcg
     3121 agtccggtcg tcgtgacgcc cggactgtgg ccgcccgaac acaagacggt cagcatctat
     3181 gttcacctcg cccgcgactg gaggatgagc gcgatcttcc cgtccgcggc ctgacgggcc
     3241 agcgcactgc cctcgccggc cgggacgacg aggtcgacca cgatgagccc gtcagcgtcg
     3301 ggctcgccga cgcggtcgac ccgagcctgg tgatcggccg gggtgccctg cccgttcgag
     3361 atggcgggcg ccacggcggc ggccacgacg cgatcaccgg gctggattcc cctggcaggc
     3421 agttggctgg gcttgagcgc caccggcacg acgacctgtc ccggtgccgg aacgagtgtc
     3481 ccggtcaggt gcgcgggtgc cagcaggctg ccggccttca ggtccacagc ggcgcgtctg
     3541 ccgatgaccg cgctcttgtc ggtagcctcc acggcccgta ctcccgagtc caagccgagc
     3601 gcgaccgtcc gaaggtcctg ggcttgcaac tgctggccga tgggaacgtc gcgcgccatg
     3661 acgagaaccg gcgtccggtg cccggcgatg ccgtacacct gccaagcgat cagcgcgccg
     3721 agagcggtca gcgcgatgct caccacgagc atcaccgggc tgcgcctgct cggtagcggg
     3781 cgcacgtgtg tggcccggcc cgcttccctg ctcggcgtgg agcgctggag catagggcta
     3841 tcccttcgtg acgagcgcct gggcttcgat gacgcggatc gggaaggtga ccgacttcgt
     3901 gatgggcggc agcgtgccgc ctgtgccacc tgaaccgcgc caggtgccgc tccaggtcac
     3961 tgacacggtc acccggtagg cgctggccgg atgctggtac gtgtgcgaac aggtggagct
     4021 ttgctgatcg gcgggccggg tgatgtcgta cgcggttccg ggcccgtcgc aggtgagcgt
     4081 ctggccgtcg ccggtactga tggtcatccg ctcgggagtg gcagtggccg cggcccagac
     4141 agcgccgatg tgcagccgct tggacttggg cgcccactgc ccgtcgggta ggaagaacca
     4201 ctgcgggagc ccgaccagcc cgttctgtcc gcgtggcgga gcggtgagca ctgtcggcgg
     4261 cgcgatcggg atcaatttgt acgcgcgacg agcgagctgc tcaggggtta ccgcatcacg
     4321 ccgtttcttg atccagacga catctcggta gccgtcggag cactcgacca ggtagtaggc
     4381 gcccttgccg gtcggctcgc tgctcaggtt gctgccagga tcgacgaact ccagaccacc
     4441 gttctcccgc ccgtcagcga accaccgctg gtaagaacat ctgaccttcg atcccttgcc
     4501 cgtcggagtc tgtgacccgg gacggggcag gcgcttggcc gaaatgatgt agcccgtgta
     4561 gtcgctcgac acgccgacgc cgtccccgtc tccgtccccg agcggggcaa tggcaagtcc
     4621 ggcgacaagg acataagtca tgccgtaggc gaacaaggct ctttcacctg ctctaccttc
     4681 gacactcgcc aggtgtcatc cgcccccttc gtgatggtgg caacaagatg aatgcgactc
     4741 gttccgtgcg tgaggcgctt tcctgtccga tcgtctgcct gaccgccttt ccgggcgtct
     4801 tggcagtcgt ggagggtggc gtggtcgccc ttgatccgta cgtcgaacgg gtgatgttcg
     4861 ggctgtcccc aggtcacccg gtgagtggcg cggagcgcgg cgattcctcg caacatccgg
     4921 ctcagaagag gctgggctgc cacctgttca aggatcgcct tgcgctctgc tgggtaagca
     4981 cgctcggcgc gttggccggc agggtagagg tcgcggtata cggcaagaac ggcatcctcg
     5041 ctagtggtgg ccgtcggtgt gggcgagagc ggcgtggtgg tacgggttgg ttctggagcc
     5101 gtgccactgg actggcaggc agtcacagcg cttgccgtga cgacgaacat cgccaccaag
     5161 ggcaaggctc gttttgggca tcgcgaaaca accctcaccg gccagcacct tcaccgtaga
     5221 aattggtcca ctacaagcag tcgccagatt agagtagtgg cccaagcgcg gcgcctaagg
     5281 gtctggtcat ccaatcatta cccgtgcttt atgaaacggc taagtcctta tggtggttgc
     5341 ctcttgccgt gcgagaagtg gagcccaaat tgcccataaa tgggagattc tccgcctgat
     5401 gggcgcttgt tctgtatagc gcactaaatg tactcaggag ttccgtgaac gtctcgaacc
     5461 gcaacctgag ggcggcaagg tatacaccgc caatgagggc ggctacgggc tcacgacatt
     5521 ccggcgtcca ccgttagcgg cccggctgct ggctttgatc gagcccgtga tcacgcgtgg
     5581 aaggctgcgc atcccgggtc agcggccatt agggcggcta cgagatgcgg aaggtcgtca
     5641 acgcgatcct ctaccagagc cgctccggct gccagtagaa ctacctgctc cacgacctgc
     5701 tgcgctggca gagacgggag aaacgacgtg gagtcagtcg tcctcggcag gtggggcgta
     5761 gttggccccc tcctcgccgg cggtgacctc atttagtagg ccgtcaatct caaccgccgt
     5821 cacatcgacg actgggtcgg ccttcgcagc gtcggccacc agcgtcggct ggttgatcca
     5881 gtcctcccat gacagcccgt acttctcagc caggtagcgg gcgcggtaga gccgtgtcgc
     5941 atcctcgata gccgaataga gcatgttgaa gctgagcccg gcaacgagga tgccgccgac
     6001 gatcggcatg acgttggcga gccgcgcctt ggtgagcggc agtctgagta gcttgaagat
     6061 ctgcaggatg acctgaacga gaggctcctt tcccaactgg ttccatgttg cgcggcgcat
     6121 catcatctgg gtgaggcacg acaggctcgc gagagtagcc gtcttggtca tgagcgatga
     6181 cgccatgccg tagttcagga cccgcatcag gaattcctcc tcttcaggct cccgagggtc
     6241 gtagccatag tggacggcga cctcggccac agcgcggccg aggagagcca acgagatcaa
     6301 cgcgtctgac gccaccaccg cgaccgcgac tcctgctgtc gtgccacccc tgacagtcgt
     6361 gctgaccctt gctccggtga tcctgacgga ggcggcgccg gattcgagta ccgcgatgaa
     6421 cgggatggtc aacatcggcc gacctttgtc gaggtccttg aggtcgagcg actcgaatgg
     6481 cgactccgca cccagatcct ggtgcttgcg acgcagcttc tcgacgcgct tctccagcga
     6541 tgtcgaaaac actgcgggca agaagatggc cttgaaacag ccttccagcg ccttgatgat
     6601 ggtctcgtca ccgagttccg tgaccttcac cgcgccgggg tccttcctga tctgctcgcc
     6661 ggtacgcttg gtgacgagtg ccaccttgct ggctccgcgt gctctcaaac tgttccggcg
     6721 cttccgctcg ttttcgagca aggtgaacca ggcccgggtc tcgtagttgg acatgtcttt
     6781 ccgcatcgat gctcctcacc gaaccattga aagtcgctca aatacagcgg gtcgtggaac
     6841 cgcctgctga ctgtgacgct ctgcggccgc gaccgcaacg tcaagttacg agctcgcgca
     6901 tgaatctggg ctatgggagt aggcagatga ggccgtcctc caggtaagca gtctggccgg
     6961 cgtctgccgc caagatggcc gcgttcatcc tccgcgccag gcctggcggc aagagcttgt
     7021 ccaggtcagc gggaggagcg aatacgtatt cgtcgagttc ctcgggctgc agacggagcg
     7081 ccgcgatttg ggaatcagtg agcacgcctg cattgaagac gaacatcagc ccggcgtccc
     7141 agggcggtgt cggtggcacc cagtcgacac atgcgagctg acctaccggc ggtgtgatgc
     7201 ccaactcctc ctgtagttca cggagcagag cactggcggg ggactcccct gcctcgacca
     7261 tcccgccggg gatgtcccat tcgtccttgt aaaccgggtg cacgacaagc acccgcccct
     7321 cgttgtctcg gagcaatgcg cctgccgcag cacgaaggcg gggtacggag gcgacgaagg
     7381 ccaggtatga cgcggagtcg ctcatgacgg ctccgacact atgagccgcg cacggcttgg
     7441 cgccggtgta tttccaaacc tcacgcggag gcagctcgta caccactggg tgggacgtca
     7501 ccggtcggca gggaaagacg gcgtgtcgcc cacggactgt tcgtaccctg agccggtgcg
     7561 taccggctct cttgataccc gtttgatcgt tctccgcggg aactccggct ctgggaagac
     7621 cagcgtcgcc cgggccgtgc gggtcgccta tggccgtggt ctggctctgg tcggccagga
     7681 cgtcgtacgg cgggagctgc tgcgggagcg ggacgtacat gggggtgtga acatcggcct
     7741 catcgacacg atcgtccggt actccctcga tcacgggtat cacgtcctgc tcgaaggcat
     7801 cctcaccgcc agccggtacg gggcgatgct gcagtcccta cgccgtgacc acgccggaac
     7861 cagcgccttc ttctacctgg acgtgtccct tccggagacg ctccggcggc atgacagccg
     7921 cccccagcgg tcggagttca ccccagacca gatgcgggag tggtatcagg agcgcgacct
     7981 gctgccggac gggtgcgaga ctgttatcgg cgaggacagt ccgctggaag cgtcggtgcg
     8041 gcaggtgctg cgccaggcgc gcctggctcc agccagacca accagtgaca acgccgcacc
     8101 catgacggcc gcctcggtcc gcggtgatcc ccgcgatcgc ggtcagtgag gtggtcgtgg
     8161 ttgagcgtat cgaggacggc gcggacgagt acgtcgtcat cggacgcctg taggcgcttt
     8221 cttcgtcatc ggtccggtcc ccgcgttcct tgtgttcctc ccgtgaggtg ctcttcggcc
     8281 agtagcctat gccggtgatt ctggctgacc ctgaccagca cacactgcgc gcggctgtga
     8341 ctgacacgta ccgcgccgag gcggagttcg atgacgcgcg ggcctggctg gaagagctgc
     8401 tgggcagccg cagcgctatc gagccgatcg cggctgaggt ctgggcgttc gacgaggccc
     8461 ttgagcgtgt tctgctcgtc aagcaccgct ggagaggctg ggtggcgccc ggcgggaagg
     8521 tcgagcaggg agaaatccca cgggacgccg cccgccgtga gctgcatgag gaaaccggca
     8581 tcgtcggcga cctgtcggac gtccccgcgg cggttttcgt gcggtcctat cgttctgatt
     8641 gggcgcccac gctcggcctt gcgtatgccg cagtgctcaa cgggtcgctc ccgctgagcg
     8701 gtgagagtca ccagcaggcc gcctgggtcc cgttgcacca cgactgggag ggcgcctttc
     8761 ccgaggacag accacggatc cgcgagtacg ccaggcatct ggcccgtacc cgagaaggta
     8821 cgggccgctg accagagcgg ctctggctgg agccgctcac gtcacgcctt tgcaattact
     8881 acgaagaccg tgagcgagtc acagaagccc gcggagtgtc acttcggccg tgtccacggc
     8941 tgtggtgaga gcgtgcatgt gggcaggtga gagcttcccg gcaccgagcc ctgacgcggt
     9001 cagtacggcg tggagtttct gtctttgctc attagccagg cgggagtaga ccgggcggtg
     9061 gttcaggacg tcgcgggcgg cgtaggcgtc gaggatggac acctccacga cggcgtcccg
     9121 cagaagggcg gggcaggggc tggtccggtc gtgggccagg tcgagtgcgg tcagtccgac
     9181 tcgggcctgg aacgtcgcgg tcgcggggtc gggcggggtg atcagagcga gtgcctcctg
     9241 cagggcatgc tcaaactccg gctgcggcgc tggtgacgtc gctgggcggc agcagatgcg
     9301 caggagggcc gcgatggcgt tctcccacgg ttccgcgggg acggtggatt cgatcgtggc
     9361 gcgagcctgc tcgtcgaggc cacgttccat cagtgacatg atcatgattt gacggccgtc
     9421 gaggaggcga ttgccgacgc cgcgatgcgc ggccatggct tcggcggcct cggtccagcg
     9481 gccgatccgg gccagggccc tggcgccgtc gatgagcacg gtgacccaca gctcctcgca
     9541 gacctttcgg tggtccgcct ctgtgtcgat cagcaccgac agatccacgt tgtggttgcg
     9601 gatctcggct gtgccgcgcc gctgagcagc gcggtacagc cgcgtgagca ggtcgtaggc
     9661 gccttcgccg tcaccttcgc ggatcagcag ccgggcgatg ttcaccagtg gcatgagtgc
     9721 catcacggcg atgtcccccg tgaggttgcc cgctttggcg aagacctggt gctgcctcca
     9781 gcacagttgc gcggccaggt cgggcatccc gacgtcggag gcgatcagcg cggcgtagtt
     9841 gaggatccca ctggcgcggg ccaccagagc gcggtggctc gcattggtgg gctcgacggt
     9901 cagctcggtg aggtggctga tgcgttcggc caggggtaac ccggccgcct tgggtcggcg
     9961 gaccagcggg atatggctgg ctatcgcggg gatcatcggc tcagctcctg cgcggccagt
    10021 cgacgacgag acggctgtag gtcttgtcga tgacgaagcg cggttcggcg gtcgtcagtt
    10081 tgtcgcgggc atcacctacg gccatgcgga agtcgggttc cggggcgttg ttgccccagc
    10141 cgcggtccca ttcgccgatc tcggtggcga cctggtcggc gagctcggcg gcgcgcgggc
    10201 cgtggccgat gacgccgatc tcccagaacc tgccctggtc gtcctcgcct tcgcgcacgg
    10261 tcaggtaggc cagggtgtcg ccgtcgagcg cggccatgga gccccagccg aagtgcgggg
    10321 tgaagccggg gcgggacccg ggcatgcgcg acaggccgtt gggcagcacg cacgccaggt
    10381 acagatacag ccactgccag gggtcgccct ggcggaactg cacgccggag tagaccttgg
    10441 ccggcggctg gtccaggacg gtgcgtatcg cctcgtggtc cacgtcctgc tcgctgaagg
    10501 tctccaggcg tacgtttccg tcaccggcca tatgcacgag ggtgtaggtg tcgtcgcaga
    10561 cgcctttgcg caggggcacg aacgtcgcca tctcgcacga gacggccttc caggtcttgc
    10621 cgtcgcgttc gaaagcgaag gatcgcgaga tgctgccgcg gatccgcatc gggatgacca
    10681 ggcgtccgtt cggggcgagc tggtcgagga tcctcagggg gatgtcgccg gcgccgacgg
    10741 tgaactggat gcggtcgaag ggggcgtgtt cgggaaggcc agcggcgccg tcggccagca
    10801 cgacggtcac gtcctgagcc ccggcctgcg cgaggttctt ctgggcgccg ttcacgaggt
    10861 cctggtcgac gtccacggtc cacacgtgac ctccgggggt gacgagctgg ccgagcaggt
    10921 gtgcgttgta gccggtggcg gcccccgctt ccaagatcct gtggccaggc ttggcgccca
    10981 gctgctccag ctgtgtggcg acgatcgagg gtgcggagat gcaagagacc atttcgccgg
    11041 tctcgtcgtg cttgatgggc acggcgtcgt cgacgtacgc ggcctgaagg tcggcgatgg
    11101 ggaggaacag gtgccgttcg gtgttccgga aagcggcgat gacgtcaggg gtgcgcaggt
    11161 ggccgctgtc gatgaggcgg gtcacgagcg cttcgcgcag ctcggcgggg tcggttgcag
    11221 gcgtcacggt ggtctccatt cgggtgaggt tagagtccgg tgaggtggac gtgcgggaag
    11281 acacgtcagc tgcctcctcg tcggcgaagg cgacgtgtcg gcccagccat gcggttgcgg
    11341 cctgctcgtc agcggacact ccggcgcggt tgaaggcgaa gatcgcgtga tgggcgagta
    11401 ccgcgcgcag accccgcgtc agccgcccat ccgcggccag ccgcctcagc cggtatccgg
    11461 cctcctcgaa cgcggcgacg cgctcggccc agccgggctc ggcgtccggc cgccgagcag
    11521 cgtcggcgtt catgaggcgc cgcatggccg ctaccgcctg gtcacgtgag gcgatggcag
    11581 gcggggtgac ggatggccgc agggagccga gcttcgccca gacgtcgccg atctcgaaag
    11641 ggtccaagcc ggccgcccgg ttcatggccg agatcagcag gatgcagcgt tcccgggcac
    11701 ctgccctgcc cgtctcggcc agggctgcgc ggctgtccgc gcagaaaacc tcatgggcga
    11761 catccatgcc ttcggggccg ccgaacgcct cgctctccgg ctcgtagaca ccgccgaccc
    11821 aaccgccggc cacttggtcg gcgacgagcc ggtccagcag gtccgcagcc gggcgctcgg
    11881 tgcgcaaccg cagcccgccg tccttgcgca ggaagtgaaa ccgctggtcg tgcagcgcgg
    11941 acgccagcgc ctgggcagcc cccaggctca cggaaccgcc tgggaacgac acactggcat
    12001 gccaccagcc ctgctcgggc gtgatcggca ggtccttatc gttcacgtcc atggtcgtgg
    12061 gcgctccttc tcagtggggg ctgggatcga atgaccggcg gggtcaggtg atcagcaggg
    12121 ccctggccca gccggtcgtg ttcgtgccgt ccagggccag ttgcgcgccg gcacggcctt
    12181 ccatgaatcc gggcttggac agccggtcca ggtcagcggc caggcgattt gtcaggtcct
    12241 cgatcagcgg cgtgtaccgg tccgggtcgg agctgtcatc ggcgacggca cgggccacgg
    12301 tcagcaggcc ggcccagccg tggcacagcg aggcatcggt gatccggctg aggcgggcct
    12361 ggtcggcgag ggcgcgcacg acggtgtcct ctgccgcgag ccggcgggcc gggtcgttca
    12421 gggcgatggc agccagctgc cgggtgcggg cgatgccgag ttctccgtag caccacgacg
    12481 ggcgcgcgac ctgcggctta ggcggctcgg gatcggacag ctggtcgcag gtgatccagt
    12541 agcagcagcc gtacctgtcc agccagcgcg cgaacacctc gatggcatca tgctgtcctg
    12601 gcacttggat gctgcgccgg gcggcgaggg acagcaccgc cagggggccg gcgatgccgt
    12661 gtgcgacacc gttgttgccg tgtccgccgg gcatctgttc atcggcgggc ccggcatccg
    12721 accaccagcc cggcagctcc cggccctgga tgcggaccgg ccggaacagg gaaaccaggt
    12781 agtccagcac ctcttccaac agtggcgagg cgtcggcgcg ggtcagcagc agcgcgccca
    12841 gcccggccaa gccccggatg aggtcgaact ccgcgagatg cggcagcgcc tcgcgggcct
    12901 gccgccgccg tgctgcggcc agtcgggcgg ccacgacgcg gtcgacggcg tcccggacgt
    12961 cgcggtcggc gcgcccggca cggctgagca cgaactccag tgccggggcg ccgtggaaca
    13021 acgacgcgtt gcctccggca ctgacaccgc ctgcaaccgc ctgcgccaag gtctttcgag
    13081 cgaatgcgag gtcaccgcgc tcgatgtgca gcagcgccac tccgagcgtg ccctcggaca
    13141 ggtcctgcgt gcggggaaga gtcgccgtca tgagcgtgcc ctcagcggga caacgaggct
    13201 gtgggcccgt ccgctgatcc agccgtcggc atccgatggt ggcgcctcgt acaggatcgc
    13261 gacaccggtc ggactggagg cgaggtgtgt gcgcagcagg tccaggtgca tgtcctggcg
    13321 cagatcaagc ggaaggtgct ggtcgtcctc ggccaggagc acgcggtccg gcaggccgaa
    13381 ccggcccatc catgcgtgca gtcgcccggt ccactcatcc agcgtcgcgg tgcgaccggg
    13441 caactcgtga gtcggcagct tccatcgtgc gggcaccagg atcgaacgcc ggtagtgcaa
    13501 cgccggggtg aacggaaggg tccaggccgc gccccagtcg aaccacgtca cctggggagt
    13561 ggtggcccga ctgatctcgg ccaggaaccg agccagggga ggggtgtagt tgttccacag
    13621 gaagttgatc gcggtcggtg cgagcacctc cacgtgcgtc ccggtggcgg cctcggtcag
    13681 atagaggcgg ccgtcgcgga gaccgacagc cagatcggaa gggaacagca cacccttccc
    13741 acggtgccgg aactccccga cgctgaccag ccggggcagc acctgcgggg cacgggtgag
    13801 cagatcggcc gacacgcggc cggcgtggaa ggacagctgg accagctcag cgccaggctc
    13861 gaccgtgggc aggccggcgt acgtcgcgcc ggtctgcggg aacagatgcc agaaccgccc
    13921 cgtcatcgaa ccggccgccc gagagacggt gaacacccga agacgaaagt ctccggcgtc
    13981 gagagcccgc gtcgaggccg cctgcagctg cacacacagt tcgaggtggg gcggggtgac
    14041 cgtacgcttg cccgcggcgc cctccaaccg ctcgatcacc gcgccggaca ggaccaccga
    14101 tcgactgcct gagacggctg cggtggcggc caactccaga agcagccggt cccggcgggt
    14161 catcgggcgg ggtggctcgg acacctggcc gaatccctcg gggaagccca agcccctctc
    14221 gggatccgtc accagctcca gcggcacctc gacgccctcg ccgtaccggt cggcgaactg
    14281 ctcgatgtaa cggcgccatg ccggagtccc cgtcgggtac atggcgagcc gggtcaggac
    14341 cgtcgcggcg gtctccgcct ccgtcacgac cgtcgtcggc agccacaccg tcgcgtccag
    14401 ccgcagatcc agcgccgccg tccggttccg ggtatcccgc agggcggccg gcagggcatc
    14461 ggccgggtca acgactgtgg cgggtgcacg cagcgacgac cgcagcagcc gcacccgcag
    14521 gagctccgcg agcagccccg tccgatggcg ttcgtccgta cccggaaact gggcggcgag
    14581 cttgtccgtc agagtcgagt accggatcgg cacccgggcc gcatccagcg ccagcgcgac
    14641 cgcgggcgtc agcgcgagcg agaactccga agcgccctcg gacggaacgt agacgcgccc
    14701 ggcccgctga cgtgccaggt tgttgacgca tacgtcgacg tcggccacct gctcgccgtc
    14761 cgcctcccag ccgctgaccg ccgcgtccag cgccaccggc tccggccggg caacagcctg
    14821 gtgcaactcc ccgaagcgga cctcagccac gtggccgaac tcgaccaggg cgacgcccgc
    14881 gaacaggccg aacggtgtcg agcggcgcgc gtacctgatc gcgtaccggg cggtggccag
    14941 tgccgcccgg cgcgcccggc gtaccttcac cgagagcctg ccgaggatcg cctggacctg
    15001 gcggtccaga tccgggctgg cgcaggaccc agcctgccga aaggcgtcat cggcccacac
    15061 tgccgccagc cacgaacgcc agcgctcgag gggcgctgtg ggacccggcc agggcggcag
    15121 gtccggcccg gtgaggtgca ccgcggcgcg cagcatcccc tcaccggcaa cccggtacag
    15181 gctgtgtcgt aagcgcgtca tcacccacac tccgttcttg acaggaaggg cgcgggccgg
    15241 agggaaccgt ccgtccggcc cgcgccgccg ggctggacct gggctacgag gtggtgcagg
    15301 cgctcgggca ggagctcccg cagttgtcgc cggtgctgca caacagcacc gtctcggtcg
    15361 ccggcgtgtt ctcgatgaag gtgatgtcga gctggaacgg gtcgtcggcc tcgtcgctgg
    15421 cgtgctggcg cggttcggcg ctccgcgtga tggtctgcgt gctcattttt gctcctgatc
    15481 cttggtggta gggacctcgg tgaccgcccg atggccgggc tctggggagc cggaccgccg
    15541 tgcgatcgcg tcctcccgat gtggactccc cgaaccgcac cggttcgggg acgtgctggt
    15601 ggccggcgtc tcaggagacg gacccagcca ccaccgcccc ttgtcggcag ctacaccggc
    15661 agggacggag cctgaacgtt cgcggccaac cgctcggggt cgaactcgcc gtccttcacc
    15721 ccgttgatga atgcgtccca ttcggcgggg gtgaacagca ggacagggcc gtcctggttc
    15781 ttgctgtcgc gcacgccgac ctcgccgctc ggcaaaacgg ccacttcaac gcaggcgcag
    15841 ttgttggcgc tccggctgct cttccgccag gaaacgctgg acagcgcgaa gcagggttgc
    15901 ggcatggact atctccgatc ttcgtgtcag cgggatggga cagattccgg cccgggtgtt
    15961 ccgcgccgtg gtgcgcgcgg gccgggcgga gtgctcgacg atgcgggaga caggggacgt
    16021 gttacgccaa ctcgggcagg gggcgctcaa ctacaccgcc gagctgtcaa tggcatcgcg
    16081 acccagggcg ccctttccgg aggcgaccgg ggtccggtgg gtttatccgg atgtcgcgga
    16141 gccgcatgaa cggcgcccga gcgcgggaag ggcaaaccag acacccttgc ccgcctgcgt
    16201 gctgtgatac agccgggccg ggcgcacgcc gcagtgccct ttggtcaggg cggcgacgat
    16261 gctcaggccg aagccgcctt cgtcaaggtg ggcgatatcg gggtcgtcgg ccacagccgg
    16321 gcacacgagg gcttcggcga gccgtttggc aacgatgtcc tcctggtcgc cgacgtcagc
    16381 gatctcatag acgatgggga accccgcgta ctgaaccagt cgcagctcac acggacctcc
    16441 ggtgtgcacg aacgcgttgg tcgccagctc actgaccacg acgtccgcct catcgagcgc
    16501 ggggccgtcc acgtgctcgg cgacgtgcga acgcaacaga cgccgagcct gctgtgggcc
    16561 gccttcgcgg ctcaactgcc aggcgctaac ccggatcagg cggtcctcag cggggatctg
    16621 cactggttct tcgggtgttg gtggtggcgt ctgggtcggg gcaataagca catccatcaa
    16681 ggtctcctga gcaggcgtct tccgggagaa cgccgccccg tcgtggtgac cgtgagcgac
    16741 gagagggtct ctcatgggat tgctactgcg agcgtggccc ctgccgcgga gagagccaac
    16801 gccgttgtgt cccagccagg ccgtcgcagg ttaggccaga ttggcctacg agaaaggtga
    16861 gctggagata cgctctcccc gatccaacag cggcgcgggc accatcaaga cgacgtacat
    16921 cactggctgg cggagggccc cgatggaccc gagtgcgaac ggcgaccgcg tctgcccggc
    16981 atgccgcttc gccaagctca gccggtacaa cccggacccg ctctgcagcc cctgcctcac
    17041 ctcggcccgg gagtcgaccg gcgtcactcc cacctgggtc tgggattcgc tgcctctgcg
    17101 gcaggcactc gcccggctcg acatgggggc ggtgctggcg atcatgcgcg gagcgtcggg
    17161 gctgagccag ctcgacttcg gcaacctgct cggctggtcc caatccgtgg tgaccaaagt
    17221 cgaacgacgc cagcggtaca ccttccacga cgtacgggaa attctccgcg tctgcgacga
    17281 gctcgggatg ccccgagcgg cattgctgcc gctcatcctg ggccgggagg atgccagtct
    17341 gggaagcgac gatgaggccg gtttttgggg agtcgacgtg gacctcgacc gccgggagtt
    17401 cggcgccgtg acctcgggat tagtcgtggc cgcgctgctg ccccctcccg agcgggtcga
    17461 tcgcgcgcac gtccgctatc tgcaggccgt cctgtcgcgg ctgcgcaccc aggaccgcac
    17521 catcggcggc gccggcctgc tgcgccaggc catgaagacc ttcacccgag tacgggcgat
    17581 gctggacgag tccgactaca ccgatcaggt cggcaggcag ctgctggtca cgaccgccga
    17641 cctcggcatc gtcactgcct ggctcgccta cgactccggc aaccagcccc ttgcccgcac
    17701 cttgtacggt caggccgcgc tgctggccgg cagctccggc gacaccgagc tgatcgtgca
    17761 cgtgtatgtg aacatggccc agcaggcgac ccatctggcc aggatcaccg gccgccgggg
    17821 caccgcgcgc gaggcgctgc ggttcgccga ccgcgcggcc gatgccgccc ggcacgcccg
    17881 ttccgccacc ctgcacgcgc tgatcgcgct tcgccaggca ctcgcccacg cccagctcga
    17941 cgacgaggtg gccttccgtg ccgcgatctg ccgggcccgc aacgagctcg accgcggcgc
    18001 ccacgacacc gaccacccct ggagcacctt cgtcacccag tcggaaatag ccggctacga
    18061 ggcgatgggc aggatcgcac tcggcgaccc cgggcgcgcc gcccgcctgt atcggtcggt
    18121 tctcggcgac ccggcccgct cgccccgtga ccgcgcttac taccgcgccc ggctcgctgc
    18181 ggccacctcc gcagccgggg accaccggac cgccgtcaag gagggcatgc agctccttcc
    18241 ggatctggga gaacggctga cctccgtccg ggtgctcaat gaactgcggc ccgtccggca
    18301 cgaggcggag ggtttcgacg aggagttctg cgaacgcttc gaccaggccg cccgtgcgct
    18361 ggccctcgtc tgatcctgag aacccggagg aacagcatga ccgaacctgt gatcttcaag
    18421 cggttcgacg ccgccggcgc ccgcgagcag cgtgaggtcg tgtcactgat ccaccgcgac
    18481 gcctacgccg agcggatcgc cactggtgac gcattcgcca gtgaccaggc cttcatgacc
    18541 cgcttcgacg cctacaccag ccgggacggc ttcgacctcg tcatggcgta cgcgggtgac
    18601 gagccggtgg gccaggcatg gggctggcct ctgcctcctg aaacgcggtg gtggaacggg
    18661 ctggaagctg aacccgagcc gggtttcatc gtcgaggacg gcacccgtac cttcgccctt
    18721 tcggagatca tggtgcggcg ggcctggact ggacagggga tcgcgcatgc cttgcacgat
    18781 gagctcctgg ccggccgcgg cgaacgacgc gccacactgc tggttcggcc ggacaacacc
    18841 acggcctacg ccgcctacgt ccgatggggt tggcagcctg tcgcccgtct ctgcccaggc
    18901 tggcccgacg cgcccctgat ggacgtgctg attcttcagc ttcccctggc acagtaaacc
    18961 tcgacgccgc ctgccggagt cgcgagcagg tcacacggtc gggtggcggc tcggtgtgat
    19021 cgggctcgag cggcccgggc gcggagacag gccaccggtg gggcacgtgc gaagcgagcc
    19081 gccaaccgag gtgaaggcgg cgccgaaggc cgcggtaatc gagctgatgc tgcgcccggc
    19141 ctaccgcggg cacggctgtc ctactgtcgc atccgcaggt agcggcgcac gcgccgtatg
    19201 agcggtgggg ctggcgggtc gtcgggacgg tgcagtcggc gccgacgcgc cggtgctggg
    19261 ccgccgcacg aacgagctca aacgcgctct gctcgatgag ggactcttcg caccctgcgc
    19321 ccagggccct gcggcgtcat gggttttccg gctctgacgg catgccccag tcgctgtatg
    19381 tggtcgttat cggtatgtcc gagccctcga aaaccgggat ggactgaatt acccgggtgg
    19441 gggcaaggtt ttgatccata acaattgtga attttacact acgattcttc gagaaggtgg
    19501 ataggaacct gtagagcggc cccacagtgg cggactttgc catcttcgac atcggggcgc
    19561 tccccttgag aaaaatctgc cctccgatca cactcttctt gacgttggaa gatgcagcca
    19621 caagatcttg gacggtgaac ggcgaactcg cccaacgaac tcggcgggct gtcatgaagg
    19681 gctcggggag attctcgtcg gcgacgcctg ctccaatatc ggcatccgtc ggattctcgg
    19741 acgcggtgtc gaaaccacgg ttgccgataa gtgttatatt tgctatggat gacttattct
    19801 cgtcgttgcc gaaatagctc agatccatcc ggtagcgggt ggcagcaggc gggtggaatg
    19861 ccagctcccc atcagcatcg aaccccatct cgtcccaccc cgacgacttc aagctgaacc
    19921 ttgccgttcc catagcctcg gctacagcga gagaagcacg ggcgacttct aggggagttg
    19981 tcggcttcgt gttggatggg gacgatttac tgggtgcagt gggcgctgcg actactaccg
    20041 gctgcgctgt tggagaaacg ctcggatctt gccgaatctt ggaatctggt tcaacgccac
    20101 cgaactgtga agtttcatga agtagtaccg gaactccaac accgactgct atagcagttg
    20161 caattccgct gaacagccag attcgtttac gtcgcttctc ttgctcgcgg ccccattggg
    20221 gcagcggttc ggtccaggat ttcacctgaa gattcaaggt caactcggtg gtttgatccg
    20281 tggtcgtctc cgagtccgga ataagtaacc taaccagttc atcagccgtc ggacgctctg
    20341 ccggctcctt cttcagagca gtagcgacaa tcgactggag atctttgggc aagccatcaa
    20401 ggttcggaac ttcattacgg agacggaaga ccacagcctc cagtggaccg gagccatacg
    20461 gtggattacc cgtcccggcc aacaccaccg tacaggccca cgcgaagacg tccgcaggtg
    20521 gacctccccg cccttcgaac tgttctgggg ccatgtatcc ggcagacccc acaacgaccc
    20581 cggtgcgcgt gatcgatgtg gcatcgagtg cctgagcgat tccgaagtca atgaccttgg
    20641 ggccagcggc ggaaagcagg atgttgctgg gcttgaggtc gcgatgcact acccccgctg
    20701 tatggatcga ccggagtgct tcagcgagtc caatcgcaat cttgcgggtg gcctcagcct
    20761 ctaaaggccc ttcttgagct atgtaatcag aaagagatgg gccatcgacg tactcggtga
    20821 cgaggtaagg agggctggcc tctaggttca tctcgatgat gcggcttgtg aagctgcctc
    20881 ctacaaggag gagtgttgtt gcctcacggc ggaaacgcgc caggaagctg tcgtcgttgg
    20941 ctagttctgg gcgcacgacc ttgatggcta caggcggccc gttcctagcc cgtcctaggt
    21001 agaccctccc cataccccca gtacccagtt gggcgagcaa tcggtaacgt ccgatgcgct
    21061 tcgggtcaat tgacgtcaac tcgctacgag ccacaggagc gcactctcac tcttggaacg
    21121 atctactggg tgagagagca tatatctcaa cccggcaatg tggaagatca gatttgtgag
    21181 acgccgactg cgtaagacag gacggcaagt cgcacaggtc gttcgtgcgc cctgcggcaa
    21241 tccgtgccac agctgcgctc gtcatgtctg gtcaagttag cttcgagggc ctggcgctct
    21301 ctgtcgcgga acctcgccgc gaactcgcag gtagtcttca gggccccaat tctgcatccc
    21361 agaggacaat gcgaacgggc tcacaccatt gggggacggc cagcgaaggt cagccgcagc
    21421 acgggtaaac caggacgtcg gccggcgctg accataccca tccttcatgc cttcccacag
    21481 accggcgaac cagacgccga ggcggtagaa gggggcgtgc cgggcgaggt cggttgccgg
    21541 atggtggacg gcgacgccgg gggcgaacca acctgtgcat ccgaagtccg acaacctcca
    21601 gctcagatcg atgccttcgt ggaagaggaa gaagtgaccg ggccagcgcc agcccgctcg
    21661 tagccgactt ggcggacgag gaccacaact tcggccatga cgctgacggt gccgggacgg
    21721 acggtgccgc cagtgggacc cagcggctca ggggcccgcc agcgtgcgcg ccatcgcctt
    21781 gaggagggtg tcgccgatcg ttaacgtcga gggtggttct ggggctggtc atcgtgtctt
    21841 ccgtacgggt gcgggcctcg aggcgttggg agccgtgtca cctgctggga gacgagcgag
    21901 gcgcatcgtc atgacgggct tccgtcatcc tgatccggcc caggctggcg gcgttcagcc
    21961 gaaaccgcgc tggatacagc ggccattccg ctaacgtcgg gcgagtgacc gccgacgctc
    22021 gttcaccgca gtccgccgat cgcctgcgca ccgagctggt caccgcgctc agggagtggg
    22081 gttcgatccg ctcccctgag gtcgccgccg ccttcgcgaa ggtccctcga gaaaggttcg
    22141 caccggaagc gccgctcgac gccgcctact ccgcccagga tgtcgtcgtc accaaacgcg
    22201 accccgacgg caaggcgacc agttccatca gtgcgccctg gctgcaagcc gagatgctgg
    22261 aggccgcccg gctgacccgc ggcgcgcgag tcctggagat cggctccggc ggctacaacg
    22321 ccgcgctcat cgccgagatc atcggcccag acggcttcgt ggtcactgtg gacatcgatc
    22381 cctgggtcac cgagcgggcg gcccgcttcc tggccgacac cgaatatcca aaggtcaagg
    22441 tcgttctcgg cgacgccgag cacgctgcca acgagtacgg cccgttcgac gccatcctcg
    22501 tgaccgccgg cgcctgggac tgcccctggg ggcggctcct tgccccggag ggccggatgg
    22561 tggttcccct acgcttcgcc accatcacca ggtccatcac cttcgtccgc gacggcgacc
    22621 ggctccaggg cctggacccc accgtgtgcg ggttcatccc catgcaaggg gccggggcgc
    22681 acaaggacca agaagccgtc ctcgctggtg gagccgtcaa gctgacgatc gaagacggcc
    22741 ccgagctcga catcggcgct ctcgaccggg cgctggtcga accccgcacc gagctgtgca
    22801 ccggcgtcga ggtcggcaga ggggaaccgt tcgacaccct caacctgtgg ctggccacag
    22861 tcgaggacag gttcggcatg atctggcagg accccgatcg tgaccgcgat ctcgtccaga
    22921 ccgccctgcg ctggtactgc ccggctctca tcacccccca cagcttcgcc tacctcaccc
    22981 ttcgcgacgc ccagccacgt gcgactgcgg cggtgcacta cgagctcggg gtgtacggac
    23041 acggccacta cggcgccgag ctcgctctcc ggctccatga ccagatcaag gtctgggatc
    23101 acgcctggcg ccaccatcct gagccaacct tcagcctcta ccccgccgac gccacagtgc
    23161 cgaatccaac tgtcggccgg atcttccgca agcggcacac acaactggtc atggcctggg
    23221 cctgagccct gcactatcag caggggttgt acgtcagtgc cgagacgccg atggatgagg
    23281 agttgcttgc tgcagcaggt cccgtctctt gcgtaagcca gggcgaatgc tgcgcgaagt
    23341 gcttgccgtt ctgaaccggc agcgctccgc gccgtttcca gaggcgatga ccgttcagat
    23401 gaccaatgac aagccagtgg gcagccgatt gagagcggct gacggcaggg cagcgaaacc
    23461 ccaggtcagg gatgtagaac cccagccact cggcggcccg actgactgac agacaccacc
    23521 tatcagagga ccgacggggg ccggcgcggt aattctgttt ctattattgg attccagggg
    23581 cgtcggaata tatatttttc gatttcccgt atcgcctatg aggtcaatta aagctcactc
    23641 tcaatctggc tgacctcctg tctccggctt gcttgatttc tcaaccctct ctccgagtgt
    23701 catttccttg ccaatccgat tccttgcctg gccaggctat cattggccaa atagggtaaa
    23761 gaaacgccga atgtcgttga gttggacgcc gttctgagat tgaattgaac cgatcaaagg
    23821 cagtgggggc gcgaaaggcg cgctcctata gaagagatcg gagatagaag atgtccaacg
    23881 gggtggctcc tggaaagtgt gttcccacca acgttcccgg ggagacgctt acgccggaag
    23941 acatggcaag ggtgacgtcg gaagattggg cggaaatccg gcggctggca cgcggctatt
    24001 gccggacggt cgacgcgacg cgatcccgta agcgcatgga cggaagcgcc acgatagtta
    24061 agcagggaca cgcgccgtac ggcaccgatg acgtttcgga tgacgtcacg caggatgcgg
    24121 ttcttctctt cgcccagcgg atccgagaca taatcgcttc ctgccgtacc gctcctgaag
    24181 gcacggcagg gtcccccgca tgggtctacg tccggcgcga tggcggtgag atgacaatca
    24241 cgcggaccac tttgcagagg tgggcggttc gcgatgctgc cgcccggaac ggataccgca
    24301 tcgatgttcc tccgagcgag gtcgacgcca cacccggcgc tcagctcatg cgtggattgc
    24361 cacacgctga gaacgtctca cgggcggccg tagctttctg cactgcgcag aacagtgccg
    24421 tcatcttccg tcaggcgttc ggagacggtc aggacttccc aaccatcaca gatgtgatgg
    24481 aggtagcggg tcaggccgat gatctgggcc gtgcgggggt cctgaacaag gtagctcaga
    24541 agcgctacgg gggcgcgtac ggctctcgcc ggaacgtgat ccgggtgcgt gatgccgcac
    24601 gcgcggagtg gcgcgaactg tcggagcgtc ttgacgacgc caggagcgcg atggtgcacg
    24661 gcggaaccaa cagcgcagag gactgacgca accggctgag aagggcctca gagagccttc
    24721 tgaggccctt tttcatgccc tcaggatgcc cgccttgatt gagagtccaa aagtagccgg
    24781 gcaagtacgg acgcttgggc tgcctcaact cccgtattca agggagaacg aaactcgccg
    24841 tgtgcacctt cacgtattcg gcgcgatgtt cgctcgtatg gtgctgtcct acggcttggt
    24901 ttcgtgccgt agagcggtaa gcctcctgac cgttcgtata gtgcgcggtg acattggtaa
    24961 aacgtcgcgg ggtgcggacg gtcgagccga tccggtcacc gtatttagat gagagcgaaa
    25021 tccgcctcac atgttgttct gtggctcacg tagccgtagc cgcaggacgg cacggtgccg
    25081 gaacggtcgg ccgtcggtgc ggcgtgcgcg gcaatgctgc gtaattgttg ccgagtgcgg
    25141 acggtcgggc cgttccggcc accgtattta agtgagcaca attcgcgacg cgagagcgcc
    25201 g
//
