LOCUS       NZ_VYTZ01000008        25123 bp    DNA     linear   CON 20-NOV-2024
DEFINITION  Microbispora cellulosiformans strain Gxj-6 Scaffold8, whole genome
            shotgun sequence.
ACCESSION   NZ_VYTZ01000008
VERSION     NZ_VYTZ01000008.1
KEYWORDS    WGS; RefSeq.
SOURCE      Microbispora cellulosiformans
  ORGANISM  Microbispora cellulosiformans
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Streptosporangiales; Streptosporangiaceae; Microbispora.
REFERENCE   1  (bases 1 to 421897)
  AUTHORS   Gong,X.
  TITLE     Screening of Novel Bioactive Compounds from Soil-Associated
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 421897)
  AUTHORS   Gong,X.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-SEP-2019) College of Land and Environment, Shenyang
            Agricultural University, No. 120, Dongling Road, Shenhe District,
            Shenyang, Liao Ning 110866, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 2.04 OR JUL-2018
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 400x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_008728085.1-RS_2024_11_18
            Annotation Date                   :: 11/18/2024 02:05:44
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,471
            CDSs (total)                      :: 7,401
            Genes (coding)                    :: 7,312
            CDSs (with protein)               :: 7,312
            Genes (RNA)                       :: 70
            rRNAs                             :: 5, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 1 (5S, 16S)
            partial rRNAs                     :: 3, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 89
            CDSs (without protein)            :: 89
            Pseudo Genes (ambiguous residues) :: 0 of 89
            Pseudo Genes (frameshifted)       :: 7 of 89
            Pseudo Genes (incomplete)         :: 80 of 89
            Pseudo Genes (internal stop)      :: 8 of 89
            Pseudo Genes (multiple problems)  :: 6 of 89
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 09:06:26
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 33422
            Orig. end                         :: 58545
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            VYTZ01000008.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..25123
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="1"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..25123
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25123
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:15123](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..15123)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    complement(472..481)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     gene            708..1319
                     /gene="casB"
                     /gene_synonym="cse2"
                     /locus_tag="F5972_RS22655"
                     /old_locus_tag="F5972_22655"
     CDS             708..1319
                     /GO_process="GO:0043571 - maintenance of CRISPR repeat
                     elements [Evidence IEA]"
                     /codon_start=1
                     /gene="casB"
                     /gene_synonym="cse2"
                     /inference="COORDINATES: protein motif:HMM:TIGR02548.2"
                     /locus_tag="F5972_RS22655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F5972_22655"
                     /product="type I-E CRISPR-associated protein Cse2/CasB"
                     /protein_id="WP_191910272.1"
                     /transl_table=11
                     /translation="MERDIAMATPYWNRAAADGTWLTDTRNRRPLGPPPGEDLAAMRAG
                     LGRGFGEVPKLWPYYTVEINDELARRGQASVEQKAEHAALALYGLHQQSKSISMHRPNV
                     RLGTALARLRASGRFSEKAIDDRVEAAATTTTPDALLIRLRGLVDLLRVVNQPLDYTEL
                     MRLIRDWHYDDGRRAARRAWALDYQLWKQTAPQGEPIAAS"
     gene            1356..2480
                     /gene="cas7e"
                     /locus_tag="F5972_RS22660"
                     /old_locus_tag="F5972_22660"
     CDS             1356..2480
                     /GO_process="GO:0043571 - maintenance of CRISPR repeat
                     elements [Evidence IEA]"
                     /codon_start=1
                     /gene="cas7e"
                     /inference="COORDINATES: protein motif:HMM:NF020902.5"
                     /locus_tag="F5972_RS22660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F5972_22660"
                     /product="type I-E CRISPR-associated protein
                     Cas7/Cse4/CasC"
                     /protein_id="WP_150935647.1"
                     /transl_table=11
                     /translation="MSKRQYVDFHIIQTVPPANLNRDDQGNPKEAQFGGARRARVSSQA
                     WKRATRQAFDDKLPKADHSTRTKRIAGQLAERVESRTGVEAEAAARIAGALLEPLGIKA
                     GKKAGDTAYLLFFGYRQLDDIVDLIADQAKTLADLDDEQLKTATKDLPVADRLKSGHPM
                     GVALFGRMVADIPSLNVDAATQVAHAISTHPVELESDYYTAVDDENEADESGAGMIGNV
                     GFNAATLYRYATVGVHQLAGNLGSVDAAIEAVGRFAEAFALSMPTGHINSFAHRTRPSL
                     VAVVVRDDQPVNLVSAFERPIRDSDGIASTSAARLAREYQRSTQQWGDTPAHVAVSHAF
                     DNDGPLTAAFGANQSVSQLLSGLNQALTASWKTN"
     gene            2465..3274
                     /gene="cas5e"
                     /locus_tag="F5972_RS22665"
                     /old_locus_tag="F5972_22665"
     CDS             2465..3274
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /GO_process="GO:0043571 - maintenance of CRISPR repeat
                     elements [Evidence IEA]"
                     /GO_process="GO:0051607 - defense response to virus
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="cas5e"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013152329.1"
                     /locus_tag="F5972_RS22665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F5972_22665"
                     /product="type I-E CRISPR-associated protein Cas5/CasD"
                     /protein_id="WP_225311746.1"
                     /transl_table=11
                     /translation="MEDELMPGPEQAVLLLRLAGPLQSWGDQSAFNRRDTRPQPTKSGV
                     IGLLAAAAGHPRHEPLGDLLGLTMGVRVDQEGTLLRDYHTVSDYQGRPLPQAGVSAKGV
                     QRPTSPAKYTHITQRFYLQDAVFVAAVAGPRPLMESLAEAVTRPAFPLALGRRSCVPSQ
                     PILLGVTSEPILDALTSQPWQAGDPARTAWERRHGRLASIDRMVTVEAVDGDQILNDEP
                     VSFDPHDRRYATRRVTHLWRSIPTGFDNPVPPADDSSAHDPFALLGW"
     gene            3282..4034
                     /gene="cas6e"
                     /locus_tag="F5972_RS22670"
                     /old_locus_tag="F5972_22670"
     CDS             3282..4034
                     /GO_process="GO:0043571 - maintenance of CRISPR repeat
                     elements [Evidence IEA]"
                     /codon_start=1
                     /gene="cas6e"
                     /inference="COORDINATES: protein motif:HMM:NF020377.5"
                     /locus_tag="F5972_RS22670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F5972_22670"
                     /product="type I-E CRISPR-associated protein
                     Cas6/Cse3/CasE"
                     /protein_id="WP_150935649.1"
                     /transl_table=11
                     /translation="MTYLSRVRINPLRAQSRTMLASPRVMHAYVCAGIPGTPDSERILW
                     RLDVDNPHRPQLFVLTQSKPDWTHIVEAAGWPDADDEHVAIGDYTPLLARIAPGREFAF
                     RLTASPVQNTNRPEKPTPAQAARIAAGDNRSFRLAHRTASAQLDWLLNRTTRNGFEIPS
                     ARTDPAIADLADDKALPAPDVRLIARDRREFSKGDRGKRITLHTATFEGRLRVTDSALL
                     TSALLQGIGPSKAYGCGLLTLAPLPSGQ"
     gene            4042..5070
                     /gene="cas1e"
                     /locus_tag="F5972_RS22675"
                     /old_locus_tag="F5972_22675"
     CDS             4042..5070
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /GO_function="GO:0004520 - DNA endonuclease activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0043571 - maintenance of CRISPR repeat
                     elements [Evidence IEA]"
                     /GO_process="GO:0051607 - defense response to virus
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="cas1e"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017558283.1"
                     /locus_tag="F5972_RS22675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F5972_22675"
                     /product="type I-E CRISPR-associated endonuclease Cas1e"
                     /protein_id="WP_150935651.1"
                     /transl_table=11
                     /translation="MADIWWKAHPHDLHRVSDRVSSVYVERSHIDRDENAVVINKRETV
                     RVPAAMVAVMLMGPGTRVTHGAINLLADSGTTVCWVGEQGVRMYAAGLGPARGAALLQR
                     QAWLVTRSKERLNVARAMYAMRFPGEDVSTATMQQLRGREGARIRRLYQAHSQRTGVTW
                     NRREYRAGDAYAAGDDLNRLLSAANAALYGICHAVIVGIGASPGLGFVHTGSAISFVLD
                     IADLYKADYTIPLAFDLAAKGLTDERDARIGLRDRIAQTRLLDRIVTDIKNLLTPGEAD
                     VLEEDVNQLWDEKHGAVSGGINWADESDLAINLGLNLVQPTMGEDHIAVVGPEFDSPGS
                     AS"
     gene            5067..5375
                     /gene="cas2e"
                     /locus_tag="F5972_RS22680"
                     /old_locus_tag="F5972_22680"
     CDS             5067..5375
                     /GO_function="GO:0004521 - RNA endonuclease activity
                     [Evidence IEA]"
                     /GO_process="GO:0043571 - maintenance of CRISPR repeat
                     elements [Evidence IEA]"
                     /codon_start=1
                     /gene="cas2e"
                     /inference="COORDINATES: protein motif:HMM:TIGR01873.1"
                     /locus_tag="F5972_RS22680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F5972_22680"
                     /product="type I-E CRISPR-associated endoribonuclease
                     Cas2e"
                     /protein_id="WP_150935654.1"
                     /transl_table=11
                     /translation="MTVVVLIAAPEGLRGHLTRWMVEVNAGVFVGNPSRRIRDRLWDLL
                     AARIGDGQAILVEPAANEQGWAVRTAGKDRWHPTDFDGLILSARRRAQPNENRPHTR"
     repeat_region   5394..8833
                     /inference="COORDINATES: alignment:crt:1.2"
                     /inference="COORDINATES: alignment:pilercr:v1.02"
                     /rpt_family="CRISPR"
                     /rpt_type=direct
                     /rpt_unit_range=38816..38843
                     /rpt_unit_seq="gtcgcccccgcgcccgcggggatgctcc"
     gene            complement(8913..10004)
                     /locus_tag="F5972_RS22685"
                     /old_locus_tag="F5972_22685"
     CDS             complement(8913..10004)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="F5972_RS22685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="F5972_22685"
                     /product="hypothetical protein"
                     /protein_id="WP_150935655.1"
                     /transl_table=11
                     /translation="MNLTETFARFPLVARPRPACAPLEGRVRGLCDLARSAERSNDRSM
                     ASAVFNQAALLASDLGLPHLARDWCHQHAALYLRMRPLDGAAARHALEPLVNLVRLRIR
                     VGDGTGAFEMLNSLYEAVTTSTDTVIDGLHVPISELTATADDDWELLQWLWTVHLADGA
                     RALTAAGRWQEALDHLRHHNGIGQRMLDGRQVAVIAHTMAGELVAARDLLEATQSGEPW
                     EDAVTTCLAALCRPGGPEGEALTVMLDRYRRLDHTAPGLVVFRTRLGLCVIDAVGGMGC
                     PEGRAVATTLITRVMASQDGYAARELLGRSGFATSLRENDAVALGHALDISGLGLGRLP
                     EALLSKLVAALASSSSLITSSSL"
     gene            complement(10001..10828)
                     /locus_tag="F5972_RS22690"
                     /old_locus_tag="F5972_22690"
     CDS             complement(10001..10828)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03891.1"
                     /locus_tag="F5972_RS22690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F5972_22690"
                     /product="thiopeptide-type bacteriocin biosynthesis
                     protein"
                     /protein_id="WP_150935657.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 6.3e-38, bitscore:
                     125.7, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDPCPWRQVNVAFPNWATAEQTAAAHLAPPMTEAETEGLITAWFF
                     IRKAPCWRLRYLPGRDAARADAHLRRRLKDLKSKRLVDDVRRVVYEPETHAFGGPEAMR
                     VAHELFHRDSRHILARTVGPFPALGRRETTILLSAVLMRAAGLDWYEQGDVWAKVAEHR
                     PGKASWPPERKAELSQAMHRLLTADVQAMCDAGGAPLAACRPWVSAFEDAGQALADLAA
                     QGRLLRGLRAVLAHHVIFHANRAGLPSSDQSTIAALALHTVFNGFSHDGDGRG"
     gene            complement(10847..12082)
                     /locus_tag="F5972_RS22695"
                     /old_locus_tag="F5972_22695"
     CDS             complement(10847..12082)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.5"
                     /locus_tag="F5972_RS22695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F5972_22695"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_225311748.1"
                     /sec_met_domain="LANC_like (E-value: 4e-40, bitscore:
                     132.3, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIGTDHEVLAVAEAVADALSDPRNAWTTASPPGGRAWPQSLAGGA
                     AGIALLHIERARAGLADWSTAHAWLSVAASGELTAAANAGLFFGAPALAFVMHTAADSS
                     SRYRRGLTTLDEAVIAITRTRLAAAHARIDRGDQPVMKEFDLIRGLTGLGIYHLRRHSD
                     HRITHDVLSYLVRLTEPLPSGTGLPPWWTNVAPNGEPNPEYPQGHANFGLSHGVGSVLA
                     LLSLAVLRNVPVAGMTDAIERICEWTDLWRQQDDAGPWWPGFITMDQVREQHVSPSLRP
                     RPSWCYGVAGTARAQQLAGMALGDTARQQTAEDAMLAALRDPAQFDLLPEIGLCHGKAG
                     LLQAAWRMAADARTPRIAAELPHQANQLAAQLARSVPDPELLDGTAGAVLALHTVGSNA
                     VASDWDAFLSLA"
     gene            complement(12079..15123)
                     /locus_tag="F5972_RS22700"
                     /old_locus_tag="F5972_22700"
     CDS             complement(12079..15123)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.5"
                     /locus_tag="F5972_RS22700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F5972_22700"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_150935659.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 4.6e-196,
                     bitscore: 647.4, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 1.2e-21,
                     bitscore: 71.9, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1e-27, bitscore:
                     92.1, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYEYLDAVVVRTAVWPVHRAPSSWPDLSEEAAGPDSWRQWLRETM
                     RMPGLLAALEQASPVLTDRVCEICEGRDVSEPAMRRAVISVMRYLLRASGRATPFGLFA
                     GVAPARIAALPTAHVGSAHRAVTKVDAGWLTEVIGRLEAGPALRPRLKVMANNLVFERD
                     GQLVLEHRPAGAAHGQPTHLSVRATAPIRTAVSMSRSPIRLGELAEKLAADFPTVPAVV
                     IDRLLADLVAQRLLVTSLRPPMTAIDPLGHLLSEIEEMAAGEFAEVAETVERLRRIVQQ
                     LTQHDDAPTSAIARSRRARLAADMAAVAPVKGSALGVDLRMDLDLAVPDSVAAEAAKAA
                     GVLIRLARRSDLGSGWVAWHSRFLERYGPRALVPVLDAADPDIGLGYPAGYLGAPSPPS
                     SPLSERDVKLLALAQRAALRGQREILLDESTVADLEAADSEAPIQPTTELTIRVHASSV
                     HSLSDGEFTLAIVGVSRTTGTTTGRFLHLFDDEERARMSALYSELPTAVRGALRAQISC
                     PALHIETENIARAPRVATHLLSPGEYHDGGEGLIALDDLALTADIHRLYLVSRSQRRPV
                     EPVVLNAVEPIKRTHPLVRFLAEVPNALSVPCASFDWGAAAGLPFLPALRYGRTILSPA
                     RWLLTAADLREGPEWEAALAAWRDEVGVPQRVYLGDGDQRLSLDLSEPAHRALLRAQLD
                     RTGTAVLRATSDADAAGWIGGHVHEIVVPLGSARKPARAPEWLHRAEEVNRDHGYLPGC
                     DGRFYLKLYGHPDRQSRVLIHHLPRLLEELGEQAQWWFLRYQDPEEHLRLRLTVPADSF
                     ALVGDWTRTLRRAGLIGRVQWDTDFPETARFGGQAALAAAETYFATDSAAALAQLAASS
                     QKGGPDVRALTAASMLDIVTAMIGDTAESLRWLIEHAVSEPSAPPRALYDQALALANPH
                     DHQNLAAHPGGAQVVSCWSRRREALTAYRRVLNETSSHMGVLLPELLHLHHVRMAGTSL
                     ENERACLHLTRAAALSWTARARRGS"
     aSDomain        complement(14395..14667)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_F5972_RS22700_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="8.10E-23"
                     /identifier="RREFam001.1"
                     /label="F5972_RS22700"
                     /locus_tag="F5972_RS22700"
                     /protein_end="243"
                     /protein_start="152"
                     /score="71.9"
                     /tool="antismash"
                     /translation="VMANNLVFERDGQLVLEHRPAGAAHGQPTHLSVRATAPIRTAVSM
                     SRSPIRLGELAEKLAADFPTVPAVVIDRLLADLVAQRLLVTSLRPP"
     gene            complement(15199..15375)
                     /locus_tag="F5972_RS22705"
                     /old_locus_tag="F5972_22705"
     CDS             complement(15199..15375)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR04363.1"
                     /locus_tag="F5972_RS22705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F5972_22705"
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_150935661.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 2.4e-18, bitscore:
                     60.5, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSIQIENAPATQAGEEDFGEWDLDVSIVESGPAADKLIRMTDDGC
                     GTSCQSACPATCP"
     CDS_motif       complement(15271..15375)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MSIQIENAPATQAGEEDFGEWDLDVSIVESGPAAD"
                     /locus_tag="F5972_RS22705_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(15199..15270)
                     /prepeptide="core"
                     /locus_tag="F5972_RS22705_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="-4.70"
                     /molecular_weight="2268.6"
                     /monoisotopic_mass="2267.0"
                     /core_sequence="KLIRMTDDGCGTSCQSACPATCP"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSIQIENAPATQAGEEDFGEWDLDVSIVESGPAAD"
                     /leader_location="[15270:15375](-)"
                     /alternative_weights="2286.6"
     misc_feature    15356..15370
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 16.98"
                     /tool="antismash"
     gene            complement(15435..16643)
                     /gene="fxlM"
                     /locus_tag="F5972_RS22710"
                     /old_locus_tag="F5972_22710"
     CDS             complement(15435..16643)
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR04364.1"
                     /locus_tag="F5972_RS22710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F5972_22710"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_150935663.1"
                     /sec_met_domain="PCMT (E-value: 4e-45, bitscore: 148.8,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTPHMDAADIAASLRAAMVRELREMDAVTSEPVAAVLATVPRHL
                     FAVGEPLEAAYAANSALVIKRDASGLALSSLSAAHIQAVMLEQAEIEPGMRVLEVGSGG
                     YNAALIQELVGAEGKVVSVDIDPDIVERARNCLKAAGYDRVEVVLADAENGMPEEAPYD
                     RIIVTAGAWDIPPAWVDQLSEAGRIVVPLRMKGLTRTIAFEPSGDVLVSRSYCLSGFVP
                     MQGSGSFSEHVVPLAEGVALRVDEEPQRFDIEALRQALDSPRLERWSGAAFDLPDELEL
                     FLLTNMPQVAMLHASEELVAQGRFAPSVTRGVLALIRGGSFAYRTKRPNEETGGFESGV
                     FAHGPEAEAVAAEYVELLRRWASDHRRRGAARIQYVPKAARTALPSRGLIRKRHGVVVV
                     SWL"
     misc_feature    complement(16883..16902)
                     /note="TFBS match to DosR, Hypoxia stress response
                     regulator, confidence: weak, score: 23.13"
                     /tool="antismash"
     gene            complement(16912..17157)
                     /locus_tag="F5972_RS22715"
                     /old_locus_tag="F5972_22715"
     CDS             complement(16912..17157)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="F5972_RS22715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="F5972_22715"
                     /product="hypothetical protein"
                     /protein_id="WP_150935665.1"
                     /transl_table=11
                     /translation="MGADGQPQEYRLSIADTGAHERWTQGDDVLHDEAAFMDDLPTQWC
                     DLRVQELTSTGWEFAGVNVDIASISSQAPTSRISTS"
     misc_feature    17213..17233
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 20.54"
                     /tool="antismash"
     gene            complement(17244..17567)
                     /locus_tag="F5972_RS22720"
                     /old_locus_tag="F5972_22720"
     CDS             complement(17244..17567)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="F5972_RS22720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="F5972_22720"
                     /product="hypothetical protein"
                     /protein_id="WP_150935667.1"
                     /transl_table=11
                     /translation="MTYLTASRPPSREESAARQVDAHLSATHNIRGGQIRTYRGVALLR
                     LGDVSVWFRAGKISWSTGELGTDGKPKITVILLHETAQAAAKIAQRYRELRGHVGLHAV
                     RIG"
     gene            18359..19246
                     /locus_tag="F5972_RS22730"
                     /old_locus_tag="F5972_22730"
     CDS             18359..19246
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017583293.1"
                     /locus_tag="F5972_RS22730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F5972_22730"
                     /product="phosphotransferase family protein"
                     /protein_id="WP_225311750.1"
                     /sec_met_domain="APH (E-value: 8.8e-22, bitscore: 72.8,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRQPLLFADIAIEAAGEAARHAGVGDQDPEILRIGDRAVLRLAEG
                     RIIARVARSLDRLDSSRREVEVARWLTDEGLTVTRPLEGEQPCIAAGTVVSLWHAVEGD
                     WTVPADLAVVLRRLHALRPPPDLTLPELEPFERLGEQIESAPALTAADRLTLRTLMRTL
                     REELADVTYELPRAVIHGDANIGNVLKTASGEVVLFDLEGLCWGPPEWDLAITAVYRDL
                     GWHTDAEYERFCEVYGFDVTRLPRYQVLRTIRELRMTCWLAQKAGDSEDIAAEVRRRIA
                     DLREPDRPRHWHPH"
     gene            19248..19868
                     /locus_tag="F5972_RS22735"
                     /old_locus_tag="F5972_22735"
     CDS             19248..19868
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="F5972_RS22735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="F5972_22735"
                     /product="SMI1/KNR4 family protein"
                     /protein_id="WP_150935669.1"
                     /transl_table=11
                     /translation="MDGDEDGMRSEVSLAQLGNELAQLTNLSAIPALSEKEVQALEGVV
                     GAPLPEEFRSFLLQFGPGVRPGPVLNLEWITDETLREQQMFAEEPESAVSVLASFPISR
                     AHVSRLPQLAAEGTKPILWFDKPMPGTMFLCGHGCTWISMLAMNGDLAGTVWMTEIGWA
                     ENMYWWPSAPWLNHDRWGFPHSGWTEPVPFLDWYSRWTRSLQH"
     misc_feature    19536..19538
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(20134..21531)
                     /locus_tag="F5972_RS22740"
                     /old_locus_tag="F5972_22740"
     CDS             complement(20134..21531)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="F5972_RS22740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="F5972_22740"
                     /product="hypothetical protein"
                     /protein_id="WP_150935671.1"
                     /transl_table=11
                     /translation="MERQPNARLADVVDQAGVSHLGLASRIGQVAKEWRVPVRPSHTQI
                     ARWIEGQKPRGITAALIAEALSRKLGRRVTLADIGLEGTTVSPEIGLNFSDVPADLVDT
                     LAQLVTADAQRREFLRSTVDVGALTQAAFGWLLSSPAQLPDGSAGRRVGMSDVEAIRST
                     TAMFADLDNRFGGAHARSAALQYLLDQIVPLLNGTYASAVGRSLFSAVAEFCLSVAWMA
                     YDSGWHGLARRYFLQALSLAHHADDRMLGASVLSAMSHQATYLGEYREALHLARAAQRD
                     LKGRAPALLRAQFAAMEARAAANLPDGAGECLKALDTAARAFNEHRPGEEPEWIAYFDE
                     SELADEHAHCFRDLGDARESYRQATRCLSVAEASPAAGGYARSRIFSRIVLATSLVDQG
                     DVEQACHIAVRVLPRIQETASIRCTTYLRDLHNRMRSHSDHPSVIDFTEQARPVLQGRQ
                     AISLPKR"
     misc_feature    complement(21621..21635)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 22.41"
                     /tool="antismash"
     misc_feature    21622..21636
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: medium, score: 23.61"
                     /tool="antismash"
     misc_feature    complement(21762..21777)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 16.04"
                     /tool="antismash"
     misc_feature    complement(21763..21776)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.32"
                     /tool="antismash"
     misc_feature    complement(21781..21798)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.2"
                     /tool="antismash"
     tRNA            complement(21858..21931)
                     /anticodon=(pos:complement(55317..55319),aa:Pro,seq:cgg)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="F5972_RS22745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="F5972_22745"
                     /product="tRNA-Pro"
     gene            complement(21858..21931)
                     /locus_tag="F5972_RS22745"
                     /old_locus_tag="F5972_22745"
     gene            complement(21967..22899)
                     /locus_tag="F5972_RS22750"
                     /old_locus_tag="F5972_22750"
     CDS             complement(21967..22899)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Metallophos_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012887230.1"
                     /locus_tag="F5972_RS22750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F5972_22750"
                     /product="metallophosphoesterase"
                     /protein_id="WP_150935673.1"
                     /sec_met_domain="Metallophos_2 (E-value: 9.5e-09, bitscore:
                     30.2, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRKAAAIPLSVLGLGVAGAGYAAVIERNWFRLRRFDVPVLAPGQR
                     PVRILQISDLHLTPRRDRLIRWVRSLASLNPDLVVNTGDTLAHPDAVEAYMRAVDPLLD
                     RPGLFVYGSNDLYAPRPKNPVRYLWRTSKGDSEQHVPSLPWEELGAAMREAGWLDMNNT
                     TARLKVADLDVHVGGIDDSHIDRDRYDEIAGPAPSDADLRLGVMHSPEPRNMSRFAEDG
                     YQLLLAGHTHGGQLCIPFYGALVTNCGIDRARVKGLSRHESSWLHVSAGLGTSPYAPAR
                     FACPPEATLLTLVPRRPVASDGTSGRKVR"
     misc_feature    22853..22868
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.27"
                     /tool="antismash"
     gene            22981..23436
                     /locus_tag="F5972_RS22755"
                     /old_locus_tag="F5972_22755"
     CDS             22981..23436
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017621627.1"
                     /locus_tag="F5972_RS22755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F5972_22755"
                     /product="GatB/YqeY domain-containing protein"
                     /protein_id="WP_111700472.1"
                     /transl_table=11
                     /translation="MSALKDKLKADLAASMKARDEVRLRTIRMALAAVNVEEVAGKEAR
                     ELSDDEVVKILTREAKKRREASEAFAGAGRAEQAQAELDEQAVLEEYLPAQLSDDELNA
                     LVDEAIAESGAQGPKAMGQVMKVLNPKVAGRAEGGRVAQAVRARLSA"
ORIGIN
        1 tggcctggag gccctgctgt ccgtccaccg tattgacctg gacagcgggt cggtggagac
       61 gagcagcctg ctgaggcagg ccgccgacct tcgggtggtt ggagcgctcc aggaggacta
      121 cccgttgcgg gtcgaggcgt tcgggatcat gtacggcaac cagtcggccg tcatcgagga
      181 cgtctaccac gatcggatcc cgttgccggt ggccgcgctg caggccgacg ctgagctgta
      241 tggcgcgctg gtggagatga ccagccaggc ggagcggctt tcccgggcgg tcaactactt
      301 gtcggcggac ctgcggcggg ctgcggggct ggacccgatc ccctgggaca aggggcagcg
      361 ccccggggag cagttgcttc accgcctgga tcccgtggtg cgccgtgtcc ttggacacgt
      421 gggcgggctc gacgacgaac gactggaagc ggcgctgctg gcctgggaac aggccgcctt
      481 ccgggccacc cgtcagatcg ccgatgacgt gttcgccgcg gtgccggagt cggtgttcgc
      541 cccgcgccgc agcagcggcg atcaggaggc gtcggctgtt aagcccgggc tcggccatgt
      601 cgagggcaaa ctgcgacgtg acctcgcggt catcttgccg cgtgccgccg agcagcggcg
      661 agccgacaga gccgtcccct cgaaaaccct tccccctact caggctgttg gagcgtgata
      721 tcgcgatggc gaccccgtac tggaaccgtg cagccgcgga cgggacctgg ctgactgaca
      781 cgcgaaatcg gcggccgctc ggcccgccgc cgggggagga cctggccgcg atgcgggccg
      841 gtcttggccg cggctttggc gaggtgccga agctgtggcc gtactacacg gtggagatca
      901 acgatgagct ggcgcgtcgc ggccaggcat cggtcgagca gaaggccgag cacgccgcgc
      961 tcgccctgta tgggctgcac cagcagtcca agagcatctc gatgcaccgc ccgaacgtac
     1021 ggctcggcac ggccctggca cggctgcgcg ccagcggcag gttcagcgag aaggcgatcg
     1081 acgatcgggt ggaagccgcg gccacgacca ctacccccga cgcgctgctg atccggctac
     1141 gcgggctggt cgacctgctc cgcgtcgtca accagccgct cgactacacc gagttgatgc
     1201 ggctgatccg cgactggcac tacgacgacg gccgccgagc cgcacgccgc gcctgggccc
     1261 tggactacca gctgtggaag cagaccgcgc cgcaaggcga gcccatagcg gcgtcctgac
     1321 ccttcccccc aaaaccggaa tgatcggaga caacgatgtc taagcgccag tacgtcgact
     1381 tccacatcat ccagacggtt ccccccgcga acctgaaccg ggacgaccag ggcaacccga
     1441 aagaggccca gttcggcggg gctcgccgtg cccgggtgtc gtctcaggca tggaagcgcg
     1501 ccacccggca ggccttcgac gacaagctgc ccaaggccga ccacagcacc cgcaccaagc
     1561 gcatcgccgg acagctggcc gagcgcgtcg aatctcgtac cggtgtcgag gctgaggcgg
     1621 cggcgcgtat cgccggcgcc ctgctggaac cgctgggcat caaggccggc aagaaagccg
     1681 gtgacaccgc ctatctgctg ttcttcggct atcggcagct ggacgacatc gttgacctga
     1741 tcgccgacca ggccaagacc ctcgcggacc tggacgacga gcagctgaag acggcgacga
     1801 aggacctgcc ggtggccgac cggctcaaga gcggccaccc gatgggtgtg gcactgttcg
     1861 ggaggatggt cgccgacatc ccctccctga acgtggacgc cgccacccag gtcgcccacg
     1921 ccatctccac ccacccggtg gaactcgaat ccgactacta caccgccgtc gacgacgaga
     1981 acgaggccga cgagtccggc gctggaatga tcggcaacgt cggattcaac gccgccaccc
     2041 tgtaccggta cgccacggtc ggcgttcacc agctcgccgg caacctcggc agtgtggacg
     2101 ccgcgatcga ggcggtcggg cggttcgccg aggcgttcgc gctgtcgatg ccgaccgggc
     2161 acatcaactc cttcgcccat cgcacccgcc ccagcctggt cgcggtggtg gtccgcgacg
     2221 accagccggt caacctggtg tccgccttcg aacggcccat ccgcgacagc gacgggatcg
     2281 cctccacctc tgccgcccgc ctggcgcggg agtaccagcg ctccacccag cagtggggcg
     2341 acactcccgc gcatgtcgcg gtctcccacg ccttcgacaa tgacggcccc ctcactgcgg
     2401 cgttcggcgc caaccagagc gtcagccagt tgctgtccgg tctgaaccag gccctgaccg
     2461 cgtcgtggaa gacgaactga tgcccggccc cgagcaggcc gttttgctgc tgcggctggc
     2521 cgggccgctg cagtcatggg gcgaccagag cgccttcaac cggcgcgaca cccggcccca
     2581 gccgaccaag tccggcgtca tcgggctgct cgccgccgcc gcgggccacc cccgtcacga
     2641 acccctcggc gacctgctcg gcctgaccat gggcgtgcgg gtcgaccagg agggcacgct
     2701 gctgcgggac taccacaccg tcagcgacta ccagggccgt ccgctgcccc aggcgggggt
     2761 gtcggccaaa ggtgtgcaga ggccgacctc acccgccaag tacacccaca tcacccagcg
     2821 cttctacctc caggacgcgg tgttcgtcgc cgccgtcgcc ggcccccgac cgctgatgga
     2881 gtctctggcc gaggccgtga cccgtcccgc gttcccgctg gcgctgggcc ggcgctcctg
     2941 cgtcccctcc cagcccatcc tgctcggcgt caccagcgag ccgatcctgg acgcgctgac
     3001 cagccagccg tggcaggccg gcgaccccgc ccgcaccgcc tgggaacggc ggcacgggcg
     3061 gctggcgtcc atcgaccgga tggtcaccgt cgaagccgtc gacggtgacc agatcctcaa
     3121 cgacgagccg gtgtcattcg acccgcacga ccgccgctac gccacccgcc gcgtcaccca
     3181 cctgtggcgt tccatcccca ccgggttcga caacccggtc ccaccggctg atgactcctc
     3241 cgcccacgat ccgttcgctc tgctgggctg gtgaccatcc gatgacctac ctgtcccgcg
     3301 tcagaatcaa cccgctgcgc gcccaaagcc ggaccatgct ggccagcccc cgcgtcatgc
     3361 acgcctacgt ctgcgccgga atccccggca cccccgacag cgaacggatc ttgtggcggc
     3421 tggacgtcga caacccgcac cggcctcagc tgttcgtcct cacccagtcc aaacccgact
     3481 ggacccacat cgtcgaggcc gccggctggc ccgacgccga cgacgaacac gtcgccatcg
     3541 gtgactacac ccccctgctc gcccgcattg ccccgggccg cgagttcgcc ttccggctca
     3601 ccgccagccc cgtccagaac accaaccgcc ccgaaaaacc cacccccgcc caggccgcgc
     3661 ggatcgccgc cggagacaac cgctcgttcc ggctcgccca ccgcaccgcg agcgcccaac
     3721 tcgactggct gctgaaccgc accacccgga acggcttcga gatcccctcg gcgcgtaccg
     3781 accccgccat cgccgacctc gccgacgaca aggccctacc cgcaccggat gtgcggctca
     3841 tcgcccgcga ccgccgcgag ttcagcaagg gcgaccgggg caagcgcatc accctgcaca
     3901 ccgccacctt cgaaggacgc ctccgcgtca ccgacagcgc tctgctcacc agcgcactac
     3961 tgcagggcat cggcccgtcc aaggcctacg ggtgcgggct gctcaccctc gcccccctgc
     4021 ccagcggcca gtgaggggcc gatggcggac atctggtgga aagcccaccc ccatgacctg
     4081 catcgcgtct ccgaccgcgt ctccagcgtc tacgtcgaac gcagccacat cgaccgggac
     4141 gagaacgccg tggtcatcaa caagcgcgag acggtccgtg tccccgccgc gatggtcgcg
     4201 gtcatgctga tgggacccgg cacccgcgtc acccacggcg cgatcaacct gctcgccgac
     4261 tccggcacca ccgtgtgctg ggtcggcgag caaggcgtac gcatgtacgc cgccggtctc
     4321 ggccccgcac gaggcgccgc cctcctgcag cgccaagcct ggctcgtcac ccgtagcaag
     4381 gaacgcctca acgtcgcccg cgccatgtac gcgatgcgct ttcccggcga ggatgtctcc
     4441 accgccacca tgcagcagct ccgcggtcgc gaaggagcac gcatccgcag gctctaccag
     4501 gcacactccc agcgcaccgg cgtcacctgg aaccgccgcg aataccgcgc cggcgacgct
     4561 tacgccgccg gcgacgatct caaccggctc ctatcggccg ccaacgccgc tctctacggc
     4621 atctgccacg ccgtcatcgt cggcatcggc gcgagccctg gcctcggctt cgtccacacc
     4681 ggatccgcca tctccttcgt cttggacatc gccgacctct acaaagccga ctacaccatt
     4741 cccctggcct tcgacctcgc agccaaaggc ctcaccgacg aacgcgacgc ccgcatcggc
     4801 cttcgcgacc gcatcgccca gacccgcctc ctggaccgca tcgtcaccga catcaaaaac
     4861 ctcctcaccc ccggagaagc agacgtactg gaagaggacg tgaaccagct ctgggacgaa
     4921 aaacacggcg ccgtatcggg cggcatcaac tgggccgatg aatccgacct ggccatcaac
     4981 ctcggcctga acctcgtcca gccgaccatg ggcgaggatc acatcgccgt cgtcggcccc
     5041 gaattcgaca gccccggctc cgcatcatga ccgtcgtcgt cctcatcgcc gctcccgaag
     5101 ggctacgcgg tcacctgacc cgctggatgg tcgaagtcaa cgccggagtc ttcgtcggca
     5161 accccagccg ccgaatccgc gaccgtctgt gggatctgct cgccgcccgg atcggagacg
     5221 gccaagccat cctcgtcgaa cccgccgcca acgaacaagg ctgggccgtc cgcaccgcag
     5281 gcaaagaccg ctggcacccc accgacttcg acggcctcat cctctcggcc cgccgccgag
     5341 cccaaccgaa tgaaaaccgc ccccacaccc gataaaccag cagctcagca agtgtcgccc
     5401 ccgcgcccgc ggggatgctc ccgatccacc tgacacgcgc actgttcatc cgaggtcgcc
     5461 cccgcgcccg cggggatgct cctcacgtac aggaggggga caccgacggt gcccggtcgc
     5521 ccccgcgccc gcggggatgc tcccccgatc gacccggacg ccgagttgcc ggacgtgtcg
     5581 cccccgcgcc cgcggggatg ctcccgatcc acctgacacg cgcactgttc atccgaggtc
     5641 gcccccgcgc ccgcggggat gctccgcgga agaccgccga ccggtgcccg accccgccgt
     5701 cgcccccgcg cccgcgggga tgctccctcg ggccgttcga cgtggccgcg tacggctacg
     5761 tcgcccccgc gcccgcgggg atgctccgag actccactgc cagcactgtc cataagggcc
     5821 gtcgcccccg cgcccgcggg gatgctcccc gtccccctca gttcgccgtt ttccgccctc
     5881 agtcgccccc gcgcccgcgg ggatgctccg accgacttcg ccgatgccct tgtcgccgtg
     5941 gggtcgcccc cgcgcccgcg gggatgctcc tctgtcctgc tcatcgatgc tgacccggaa
     6001 caggtcgccc ccgcgcccgc ggggatgctc ccatgccgta ggcgatgccg ccgtcgccca
     6061 cggagtcgcc cccgcgcccg cggggatgct cccaccatcg gggtggacat cgacgacgac
     6121 gggatgtcgc ccccgcgccc gcggggatgc tccagctcgc cgggggcctg cccttcgacg
     6181 tggagggtcg cccccgcgcc cgcggggatg ctcctcggca catcagacac aacggtcggt
     6241 ggcgccaagt cgcccccgcg cccgcgggga tgctccgcgc ttggctggcg tgctcagccc
     6301 ggagtggcgg tcgcccccgc gcccgcgggg atgctccgcg cttggctggc gtgctcagcc
     6361 cggagtggcg gtcgcccccg cgcccgcggg gatgctccac gtaccggccg ttgaccatcg
     6421 cggagctgta cgtcgccccc gcgcccgcgg ggatgctccc gtcaaggccc ggcagatgcg
     6481 gcacggccgg cggtcgcccc cgcgcccgcg gggatgctcc gtggtccggt gacgggctcg
     6541 ccgacggtac gccgtcgccc ccgcgcccgc ggggatgctc ccagccccac caggaccacg
     6601 ggcagggtca gcgtgtcgcc cccgcgcccg cggggatgct ccctacatca agggccggta
     6661 cggcgacccc gaggggtcgc ccccgcgccc gcggggatgc tccgcgtgcc ctggccaggg
     6721 aaggcgcggc gatcacgtcg cccccgcgcc cgcggggatg ctcccgcccg cagtggcggc
     6781 ctggccggat tcgaaacgtc gcccccgcgc ccgcggggat gctcccctca cccgtgacga
     6841 tcatcgttgg taggtacggt cgcccccgcg cccgcgggga tgctcccccc gggctgaggt
     6901 ggtagcccag catgctcgcg tcgcccccgc gcccgcgggg tcctcaagag cactccgatg
     6961 tgcaggtctg caacggtcgc ccccgcgccc gcggggatgc tcccgtcacg accaccgcga
     7021 ccgcccccgt caccaagtcg cccccgcgcc cgcggggatg ctcctgcggg catagccgcg
     7081 taggtgtccc cggggtcgtc gcccccgcgc ccgcggggat gctccctgcg agagatcgcg
     7141 gcaacggtgg atgttgcggt cgcccccgcg cccgcgggga tgctccgccg ccgtgagccc
     7201 gcggatattc ctgctcatgg tcgcccccgc gcccgcgggg atgctccggg aaccaccgtg
     7261 ttccccgatc tgagccgccc gtcgcccccg cgcccgcggg gatgctccgt ggctcgcggc
     7321 caccggcaag gacatcgtga cgtcgccccc gcgcccgcgg ggatgctccc tgggtcagtc
     7381 gcgtcagctc ggcgtggtcg tcgtcgcccc cgcgcccgcg gggatgctcc tcgggattgt
     7441 tacccgattc cctgagactc cctgtcgccc ccgcgcccgc ggggatggtc cccaacgcga
     7501 tgaggccctg caccggcacc ggcagtcgcc cccgcgcccg cggggatggt cccttcaagg
     7561 ccgtgttcgg tggtggcacg gtgacgtcgc ccccgcgccc gcggggatgg tccctgctcg
     7621 ccgtagattc cgcccaactt ggaggcgtcg cgcccgcgcc tgcggggatg gtccctggag
     7681 cggctccgcg aggtgctcgc gtccgccgtc gcccccgcgc ccgcggggat ggtccgcgca
     7741 agcacgcgcg gacgccgccg atcggcgcgt cgcccccgcg cccgcgggga tggtccccgc
     7801 ctgcccatct tcggcgggtc gctactcgtg tcgcccccgc gcccgcgggg atggtccacg
     7861 ggactttctc ctcgttctac cggtccagcc gtcgcccccg cgcccgcggg gatggtcccc
     7921 tgaggaaggg gatggacgcg acgtacccga cgtcgccccc gcgcccgcgg ggatggtcct
     7981 acacggcgtc gcctggtcac tgagctgccc ccgtcgcccc cgcgcccgcg gggatggtcc
     8041 agcacatgtc acacgactct gacgtgatca ccgtcgcttc cgcgcccgcg gggatggtcc
     8101 cgccggtcag ctcccgatac cgcgcgagga cgtgtcgccc ccgcgcccac ggggatggtc
     8161 ctacttctga gcgatcttgg acaggttgtc accggtcgcc cccgcgcccg cggggatggt
     8221 cccgtctcgt gaccggaggg cttggcgtct acggagtcgc ccccgcgccc gcgggatggt
     8281 ccgaccaggg tcggccaggt catcaaggtg aagaccgtcg cccccgcgcc cgcgggggtg
     8341 gtcccccgcc gaaggtgccg acgtacggga tctcgacgtc gcccccgcgc ccgcggggat
     8401 ggtcccagcc acgggttgcg ctcgatcatc ggcgtgaggt cgcccccgcg cccgcgggga
     8461 tggtcctccg attccccccg agctgcgcgc cgcggtggag tcgcccccgc gcccgcgggg
     8521 gatggtcccc cggtcctcct ggccacggtc gcgagctgct tgtcgccccc gcgcccgcgg
     8581 ggatggtccg cacagtcccg gacttgccgt catcttcccc tggtcgcccc cgcgcccacg
     8641 gggatggtcc ctacggcggc gcggacctca cgagccaggc attgtcgccc ccgcgcccgc
     8701 ggggatgctc ccctcgtcta ccagctgacc cccaagtcgg ccgagtcgcc ccctcgcccg
     8761 aggggatgct ccttacgagc gcgagatccg cgaggcctgg gcgaagtcgc cctcgcgtcc
     8821 gcggggatgg tccctttggg ccgagattca aggctgctta ttgaagacgc ccccgcctgc
     8881 tgcggtgacc cgattaccaa agtcaggcgt gactatagtg agctgctcgt aatcaatgag
     8941 ctactgctag ccagcgcggc tacgagcttg ctcaggagtg cctctggcag ccgtccgagt
     9001 cccagcccgc tgatgtcgag tgcgtgcccg agagcgacgg cgtcattctc tctcagcgac
     9061 gtcgcgaatc cggaacgtcc gagaagttcc cgggcggcgt agccgtcctg ggacgccatc
     9121 acccgcgtga tcagtgtggt ggccaccgcg cgtccctctg ggcatcccat gccgccgacg
     9181 gcgtcgatta cgcacaagcc cagccgggtc cggaacacca ccagaccggg tgcagtgtgg
     9241 tcgagcctcc ggtagcggtc cagcatcacg gtgagagcct cgccttccgg gcctccgggt
     9301 cggcagagtg cggccaggca cgtggttacg gcgtcctccc atggctcgcc agactgggtg
     9361 gcctccagca ggtccctcgc tgcgacgagt tcgccggcca tggtgtgcgc gatgaccgcg
     9421 acttggcggc cgtcgagcat gcgctggccg atgccgttgt ggtggcgcag gtgatcgagg
     9481 gcctcctgcc atcggcctgc ggccgtcaag gcgcgtgcgc cgtcggcgag atggacggtc
     9541 cacagccact ggaggagttc ccagtcatcg tccgcggtgg cggtgagctc ggatatgggc
     9601 acgtgcagcc catcgatgac ggtgtcggtg ctcgtcgtga cagcttcata caggctgttg
     9661 agcatctcga acgcgccagt accgtcgccg acgcggatgc gtagacggac gaggttcacg
     9721 agtggttcga gggcatggcg ggcagcagcg ccgtcgagag ggcgcatgcg caggtagagg
     9781 gcggcatgct gatggcacca gtccctggcc aggtggggca ggccgaggtc gctggccagg
     9841 agggcggcct ggttgaagac ggccgaggcc atcgatcgat cgttgctgcg ttcggctgag
     9901 cgggccagat cgcacaggcc acgtacgcgt ccttcgagtg gggcgcatgc cgggcgtggc
     9961 cgggcgacga gcggaaaccg agcgaaggtc tcagtgagat tcatccgcgc ccatccccat
    10021 cgtgggaaaa cccgttgaac accgtgtgga gcgcgagcgc ggcgatggtc gattgatcgc
    10081 tgctcggtag gcccgcccgg ttggcgtgga agatcacatg gtgggcgaga acagcgcgga
    10141 ggccgcgcag cagccgaccc tgagcggcga ggtcggccag ggcttggccg gcatcctcga
    10201 aggcggacac ccatgggcgg caggcggcca gcggagcgcc cccggcgtca cacatcgctt
    10261 gcacgtccgc ggtcagtaga cggtgcatgg cctgggacag ttcggccttg cgctccggcg
    10321 gccaggacgc tttaccgggc cggtgctcgg cgaccttggc ccagacgtcg ccctgctcat
    10381 accagtcgag gccggcggcg cgcatcagta cggcggacag cagaatcgtc gtctccctgc
    10441 gtccgagcgc gggaaagggc ccgacagtgc gggccagtat gtggcggctg tcgcggtgga
    10501 aaagctcgtg ggcgacccgc atggcctctg ggccgccgaa ggcatgcgtt tccggctcgt
    10561 aaacgacgcg cctgacgtcg tctacgagcc gcttgctctt gaggtcttta aggcgacgac
    10621 gcaggtgggc atcggcccga gcagcgtcac ggccgggcag gtagcgcagg cgccagcagg
    10681 gcgccttgcg gatgaagaac caggcggtga taagtccttc ggtctcggcc tcggtcatcg
    10741 ggggagcgag gtgtgccgcg gcggtctgct cggccgtggc ccagttaggg aaggcgacgt
    10801 tgacctgacg ccaggggcag gggtccatgg gggttggctc cagtgttcag gccagcgaga
    10861 ggaaggcgtc ccagtccgat gccacggcgt tgctgccgac ggtgtgcagg gcgagtacgg
    10921 ccccagcggt gccgtccagg agttccgggt cgggcacgga gcgggccagc tgtgcggcaa
    10981 gctggttcgc ctggtggggg agttcggcag cgatgcgtgg ggtgcgggcg tcggcagcca
    11041 tccgccaggc ggcttgaagc agtccggcct tcccgtggca gagtccgatc tcggggagca
    11101 ggtcgaattg tgcgggatca cgcagcgcgg cgagcatcgc gtcctccgct gtctgctgtc
    11161 gcgcggtgtc tccgagcgcc atgccggcca gttgctgagc gcgggccgta ccggcgacgc
    11221 cgtagcacca tgagggccgg ggccgcagcg acggactgac gtgctgctcg cggacttggt
    11281 ccatggtgat gaagccgggc caccacggtc ccgcgtcgtc ctgctgtcgc cagagatcgg
    11341 tccactcgca gatccgctcg atcgcgtcgg tcatccccgc cacgggaacg ttgcgcagca
    11401 cggctagcga cagcagggcc aggaccgagc cgacgccgtg ggacaggccg aagtttgcgt
    11461 gtccctgcgg gtattccggg tttggctcgc cattgggcgc gacgttcgtc caccacggcg
    11521 gaagcccggt ccccgagggc agcggttcgg tcaggcgcac caggtaggac agcacgtcgt
    11581 gggtgattcg gtggtccgag tggcgtcgca gatggtagat gcccaggccg gtcagtccgc
    11641 gtatcaggtc gaactccttc atcacgggct ggtcgcctcg gtcgatgcgt gcgtgcgccg
    11701 cagcaaggcg tgtacgggta atggcgatga ccgcctcgtc cagagtggtc agcccgcggc
    11761 ggtatctgct ggaggagtcg gcggctgtgt gcatgacgaa ggcgagggcc ggggcgccga
    11821 agaacaggcc cgcgttggcc gccgcggtca gctcgccgga ggcggccacc gacagccatg
    11881 cgtgggcggt gctccagtcg gcaaggccgg cgcgagcgcg ttcgatgtgc agcagggcga
    11941 tgcccgccgc gccgccggcc agtgactgtg gccacgcccg ccccccaggc ggcgatgcag
    12001 tggtccacgc gtttcgcgga tctgacagtg cgtcggcgac ggcctcggct acggccaaca
    12061 cttcatggtc ggtaccgatc acgatcctct ccttgctcgc gccgtccagc tcagtgcggc
    12121 ggcacgggtc agatgcaggc aggcgcgctc gttttccaac gaggtcccgg ccatgcggac
    12181 gtggtgcaga tgcagcagct cgggaagcag aacgcccata tggctgctgg tctcattgag
    12241 tacgcgccgg taggcggtca gtgcttcccg cctccgggac cagcaggaga cgacctgtgc
    12301 gcctccgggg tgggcggcca ggttctggtg atcgtgaggg ttggccagcg cgagggcctg
    12361 gtcgtagagc gcgcggggcg gggcagaggg ctcggacacg gcgtgttcga tcagccagcg
    12421 cagcgactcc gcggtgtctc cgatcatggc ggtgacgatg tcgagcatgc tcgccgcggt
    12481 cagcgcgcgt acgtcggggc cgcctttctg gctgctggcg gcgagttgcg cgagggccgc
    12541 ggccgagtcc gtggcgaagt acgtctctgc tgcggccagt gccgcctgac cgccgaagcg
    12601 ggccgtctcc gggaagtcgg tgtcccactg cacgcgcccg atcagaccgg cgcggcgaag
    12661 cgtacgggtc cagtccccta caagcgcgaa gctgtcggcg ggcaccgtca gccgcagacg
    12721 cagatgctct tcagggtcct ggtagcgcag gaaccaccat tgggcctgct cacccagctc
    12781 ttcaagcagg cgcggcaggt ggtggatgag gactctgctt tgccggtccg gatggccgta
    12841 cagcttgagg tagaagcgcc cgtcgcagcc aggcaggtat ccgtggtcgc ggttgacctc
    12901 ctctgctctg tgcagccatt ccggcgccct cgcgggcttc cgagccgagc ccaacggcac
    12961 gacgatctcg tggacgtgcc cgccgatcca tcccgccgcg tcagcgtcgg aggtggcgcg
    13021 tagcactgcg gtgccggttc tatccagctg ggcacgcagc agtgcccggt gggcgggttc
    13081 ggacaaatcc aggctgaggc gttggtcccc atcgccgagg tagaccctct gcggcacgcc
    13141 gacctcgtcc cgccaggcgg ccagagccgc ctcccactcc ggcccttcgc gcaggtcggc
    13201 ggctgtgagc agccaccggg cgggagacag gatcgtacgt ccgtagcgca gcgctgggag
    13261 gaacggcagg ccggcggcgg ctccccagtc gaacgaggcg cacggaacgc tgagggcgtt
    13321 cgggacctcg gccaggaacc ggaccagcgg atgagtgcgc ttgatgggtt ccaccgcgtt
    13381 gagcacgacg ggttcgaccg gtcggcgctg ggagcgagag acaaggtaga ggcgatggat
    13441 gtccgcggtg agggcgaggt cgtccagcgc tatgagccct tcgccgccgt cgtggtactc
    13501 acccggagaa agcaggtgtg tcgcgacccg aggggcgcgg gcgatgttct ccgtctctat
    13561 gtgcagagcc ggacaagaga tctgcgctct gagcgcgccg cggaccgcgg tgggcagctc
    13621 tgaatagagc gcggacatcc gcgcgcgttc ctcgtcgtcg aacaggtgca ggaaccgccc
    13681 ggtcgtggtg ccggtcgtac gtgacacccc gacgatcgcg agggtgaact ccccatcgct
    13741 cagagaatga acgctggacg cgtggacacg aatggtcagt tcggtggtgg gctggatcgg
    13801 cgcctctgaa tccgcggcct ccagatctgc caccgtcgat tcatccagca ggatctcgcg
    13861 ctggccgcgc agcgcggccc tctgcgccag cgccagcagc ttcacgtccc gctcggacag
    13921 tgggctcgaa ggcggcgacg gtgcgccgag gtagccggcc ggatagccga gcccgatgtc
    13981 gggatcggcg gcgtcgagga ccggcaccag ggcccgcggc ccgtagcgct ccaggaagcg
    14041 gctatgccag gcgacccagc cggagccgag gtctgagcga cgggcgagcc gtatgagcac
    14101 gcccgcggct ttcgccgcct cggcggctac cgagtccgga accgcaaggt ccaggtccat
    14161 ccgcagatcg acgccgagcg cggacccctt caccggggcg acggcggcca tgtcggcggc
    14221 aaggcgcgca cgacggctac gcgctatcgc cgaggtggga gcgtcgtcgt gctgggtcaa
    14281 ttgctgaacg atccggcgta gacgctcgac agtctcggcc acctcagcga actccccggc
    14341 tgccatctcc tcgatttccg acaggagatg accgagggga tcgattgcgg tcatcggagg
    14401 gcgcaggctg gtgacgagca ggcgttgcgc caccaggtcc gccagcagcc ggtctatgac
    14461 aacggcagga acggtcggga agtcggccgc gagcttctcc gccagctctc ccagccggat
    14521 cgggctgcgg gacatgctca cagccgtccg gatcggtgcg gtggcccgta cgctcaaatg
    14581 cgtcggctgg ccgtgagccg ctccggcggg acggtgctcc aacaccagct ggccatcacg
    14641 ctcgaacacg aggttgttgg ccatcacctt caaacgcggt cgcagcgccg ggccggcttc
    14701 caggcgcccg atcacctccg tgagccaccc ggcgtcgacc ttggtcacgg cgcgatgggc
    14761 gctaccgacg tgggccgtgg gcagggcggc gatccgagcc ggggcgacac cggcgaacag
    14821 gccgaacggc gtcgcccgtc ctgaggcacg aagcaggtag cgcatgaccg agatcaccgc
    14881 ccggcgcatc gccggctcag agacgtcccg tccctcacag atttcgcaga ctcggtcggt
    14941 caggaccggg ctggcctgct ccaacgcggc cagcaagcca ggcatccgca tggtctcccg
    15001 cagccactgc cgccaggaat ccggtccggc cgcttcctcg ctcaggtccg gccacgaact
    15061 gggcgcccgg tgcaccggcc agacggccgt tcgcaccacg acagcatcga gatactcgta
    15121 catgtgccgc tcccggagac ggaaagcgcc cggccggcgc ggcgaccggg cgcgttcaaa
    15181 gggccgaggc gtcagcgcct acgggcaggt ggcggggcag gcggactgac acgacgtccc
    15241 gcagccgtcg tcggtcattc ggatgagctt gtccgccgcc ggaccggact cgacgatcga
    15301 gacgtccagg tcccactccc cgaagtcctc ctccccggcc tgcgtagccg gtgcgttctc
    15361 gatctgaatg gacatgagaa cctccttggt ggtggtgcag ggtccccggt tctccctgtt
    15421 gggagccggg cgcttcagag ccaggagacg acgacgactc cgtgccgttt cctgatcagc
    15481 cctcgggaag ggagggccgt tcgggcggcc ttcgggacgt actgaatgcg cgcggcgccg
    15541 cggcgccggt ggtcgctcgc ccaccgccgt agcagttcca cgtactccgc cgcgacggcc
    15601 tcggcttcgg ggccgtgagc gaagaccccg ctctcgaaac cgccggtctc ctcgttcggc
    15661 cgcttcgtcc ggtaggcgaa actgccgcca cggatcaggg caagaacgcc cctcgtcacc
    15721 gacggagcga aacgcccctg tgcgaccagt tcctcgctcg cgtgcagcat ggcgacctgc
    15781 ggcatgttgg tgaggaggaa cagctcaagc tcgtcgggca ggtcgaaggc cgcccctgac
    15841 cagcgttcca gcctggggga gtccagtgcc tgccgcagcg cctcgatgtc gaaccgctgc
    15901 ggctcttcat cgacccgcag cgcaactcct tcggcgagcg gcacgacgtg ctcgctgaac
    15961 gaaccggacc cctgcatcgg cacgaagccc gacaggcagt agctgcggct caccaggacg
    16021 tcgccgctgg gctcgaaggc gatcgtgcgg gtcagccctt tcattcgcaa cgggacgacg
    16081 atcctgccgg cttcggagag ctggtcgacc caggctgggg ggatgtccca ggctccggcc
    16141 gtgacgatga tccggtcgta cggcgcttcc tccggcatgc cgttctcggc gtcggccagc
    16201 accacctcga cacggtcgta gccggctgcc ttgaggcagt tgcgagcgcg ctcgacgatg
    16261 tcggggtcga tgtcgaccga gacgaccttt ccctccgcgc cgacgagctc ctgaatcaga
    16321 gcggcgttgt aaccacccga gccgacctcc aggacccgca tgccgggttc gatctcggcc
    16381 tgctccaaca tcaccgcctg gatgtgggcg gccgacagag agctcagcgc caggccgctc
    16441 gcgtcccgct tgatcaccag ggcgctgttc gcggcgtacg cagcctccag cggctccccc
    16501 acagcgaaca ggtgcctggg tacggtggcg aggaccgcgg ccacgggctc ggatgtgacc
    16561 gcgtccatct cgcgcagctc gcgcaccatc gcggcccgca gcgaggctgc aatatcggcc
    16621 gcgtccatgt gcggtgtagt catcagcgct tccttcggag gttgacgggg cggcggggtc
    16681 gccgcctcgg tgatcgtggt ccctcggcag aggccgtgtg gcctcctcgt caaactttgc
    16741 ggtcgtatac ggccggtctt gtggggttgc cagtacgagc tgacttcgcg tcgtcagcgg
    16801 cccggcccag gcgttgcatg cggtacgtcc tgggccaggc cggatgctcg acggtgcggg
    16861 agtcgggggc cgcccctgtg ggcgaggggc actcgaccac gccgccgagg gctatgaggt
    16921 ggagatccgg ctcgtcggtg cttggctgga tatcgacgcg atgtcgacgt tcacgccggc
    16981 gaactcccag ccagtgctgg tcagctcctg cacgcgcagg tcacaccact gcgtcgggag
    17041 gtcgtccatg aaggcggctt cgtcatggag tacgtcgtcg ccctgtgtcc atcgttcatg
    17101 tgcgccggta tcggcgatgc tcagccggta ttcctgcggt tggccgtcgg ctcccactcg
    17161 tcggaacctc agggtcgtgg tggcacccgc ccggggtggc cagatgccct tcaggcacag
    17221 cacaagccat agcagcgaca cggtcacccg atccgtaccg cgtgaaggcc gacgtgccca
    17281 cggagttccc ggtagcgttg ggcgatcttg gcggccgcct gtgcggtctc gtgcaggaga
    17341 atgacggtta tcttcggctt gccgtccgtg ccgagctctc cagtgctcca ggagatcttc
    17401 cccgcacgga accagacgga cacgtcgccg aggcggagca gcgcgacccc tcgatacgta
    17461 cggatctgcc caccacggat gttgtgcgtg gccgagaggt gggcgtctac ctgccgagcg
    17521 gcggactctt cacgactcgg tggtctcgag gcggtcaggt atgtcatgtg gttctcctgg
    17581 acaggaacgg gtgggtgagg cggggacttc gggggcgtcg gctcctggcg tgccgccggt
    17641 gttccggccg acttcggcga ggacgcgttc gatgcgatcg gccgctgtgg ggatgtcgtc
    17701 gacagcggcg atgagcgtcg gccacgggaa ccagtagtgc caggctccgt ccgaatcggg
    17761 cttggcgaga acctgctccg taagcgccgg agctgcgggg ttcatcacct gcagttgggg
    17821 gatgcgattg agaggggtga cgatccgggt ggagaagttc cggcttcgca gctcctcagc
    17881 aagcgtctcc aggggttccg tcgcggggtg ggatgttgac atagacgatc tccggatgca
    17941 cgtgtcagcc aggggcaggc tttgctcccg tcaggtcggg gggcggatgg cgacgggccg
    18001 ggggagcccg ccgcgaggac agcaggagcg gcgcctcgcc gttctcgtcc agtagcgagc
    18061 tgctgtgcat gctgtccatg accgatagcc aaccgctcgg gaacggcgtc cgggagcgct
    18121 cagcggctct gcatctgtgc aaacccctgt gcattccgat ttgctcgtca ccatggcctt
    18181 actgcaggga tggagcccca actacgctgc ggcgtatggg ccgtcagtcc aacgctcgga
    18241 ctcgccgacg tcatcgagca ggccggtgtc tctcacctcg acttggtcgg ccgcttcagt
    18301 cgagtggtgc ggtgaatcga tggccggcgc gtgaagaccg agcgaaggaa agcacttgat
    18361 gcgtcagccc ctgctgttcg ctgatatcgc tatcgaggct gccggtgagg ctgcgcggca
    18421 tgctggcgtt ggcgatcagg atccggaaat tctgcgtatc ggggaccgcg ccgtgttgcg
    18481 gctggccgag gggcgcatca tcgcccgcgt tgccaggagc cttgatcggc tggattcgtc
    18541 tcgccgtgag gtcgaggtcg ctcggtggct gacggatgaa gggctcacgg ttactcggcc
    18601 cttggagggt gagcaaccgt gcatcgcagc cggaacggtg gtgtctctgt ggcacgcggt
    18661 ggagggcgat tggactgtcc cggctgacct cgccgtggtg ttgcgacgcc tacacgccct
    18721 ccggcctccg cccgacctca cgttgcccga gctggagcca ttcgagcgac tgggtgagca
    18781 aatagagtcc gcacctgcgc tgacggcagc tgatcggctg acattgcgga cgctgatgcg
    18841 tactctgcgc gaggagcttg ccgatgtgac ttacgagctg ccgcgagcgg tgatccacgg
    18901 tgacgccaac atcggcaacg tgctgaagac agcctccggt gaggtggtgc tgttcgacct
    18961 ggaagggttg tgctgggggc cgcccgaatg ggatctggcg atcacggcgg tctaccggga
    19021 tctggggtgg cacaccgacg ccgagtacga gcggttctgc gaggtttacg gattcgacgt
    19081 gacgcgactg cctcgctacc aggtgctgcg cacgatccgg gaactgcgca tgacctgctg
    19141 gctggcgcag aaggccggcg acagcgagga catcgctgct gaggtgcgcc gcaggatcgc
    19201 cgacctgagg gagccggaca ggccgcggca ctggcaccct cactgacgtg gacggagacg
    19261 aggatggcat gcgatccgag gtcagtttgg cccagctggg caacgaactc gcccagctca
    19321 ccaacctgtc ggctatcccg gccctgtccg agaaagaagt gcaggcactc gaaggcgtcg
    19381 tgggggcacc tctaccagag gagttccgct cgttcctgct ccagttcgga cccggcgtcc
    19441 ggcctggccc ggtgctcaat ctggagtgga tcaccgacga aactctgcgc gagcagcaaa
    19501 tgttcgcgga ggaaccggaa tccgcagtct ccgtattagc ttctttcccg atcagtcgcg
    19561 cccacgtgtc ccgcctgcca cagctcgcgg ccgagggcac caaacccatc ctctggttcg
    19621 ataagccgat gcccgggacc atgttcctct gtggccacgg ctgcacgtgg atcagcatgc
    19681 tggcgatgaa cggtgacctt gccggcacgg tgtggatgac ggagatcggc tgggccgaga
    19741 acatgtactg gtggccgtcc gcaccttggc tcaatcacga tcggtggggc ttcccgcaca
    19801 gcggatggac ggagccggtg cccttcctcg actggtactc cagatggact cgaagtctcc
    19861 agcactaact tctgtgctca gcagcgatag agcggaaaaa gtcggtctgt aggccgggtt
    19921 ccaattccgc acactcctta cctgcggcga aatgtcctac ttcaggagct acctgcggga
    19981 cacttccgtt cgtttcatcg cttgccagcg tttctcgacc gcatgtgccc cggtattccc
    20041 tctcccgctt cccttctctc cttactgtct gcgtcactct catggtctcc aggttcttcg
    20101 gcgttgtggt gccgctcgtg gcctacaacc cgttcacctc ttggggagag agatcgcttg
    20161 acgtccttgg agcacgggcc gggcctgttc agtgaagtcg atgaccgatg gatggtcgct
    20221 gtgcgatctc atgcggttgt gcaggtcacg aaggtacgtg gtacagcgga tcgacgcggt
    20281 ttcttggatc cggggcagga cccgtacggc gatgtggcat gcctgttcca catcaccctg
    20341 atcgacgagg ctggtggcga gcacgatccg cgagaagatc cggctgcgtg cgtagcctcc
    20401 tgcggccgga ctggcctcgg caactgacag gcagcgggtg gcctggcggt atgactccct
    20461 ggcgtcaccc aggtcccgga agcagtgcgc gtgctcgtcc gccagctcgg actcgtcgaa
    20521 gtacgcgatc cactccggct cctcaccagg cctgtgctcg ttgaacgccc gcgcggcggt
    20581 atcgagagcc ttgaggcact ctccggctcc gtcggggagg ttggcggcgg cgcgggcttc
    20641 catcgcggcg aactgcgctc tgagcagtgc cggagctcga cctttcagat ctcgctgcgc
    20701 ggcgcgagca agatggagag cctcgcggta ttcccctagg taagtggcct gatgggacat
    20761 cgccgaaagc acactggcgc cgagcatcct gtcgtccgca tgatgggcca gagaaagcgc
    20821 ctgcaggaag tagcggcggg cgagaccgtg ccagccgctg tcgtaggcca tccaggccac
    20881 agacaggcag aactcggcaa ccgcgctgaa cagcgaccgc ccgacggccg aggcgtacgt
    20941 gccgttcagc agcgggacga tctggtccag caggtattga agggcggccg agcgagcgtg
    21001 cgcaccaccg aaacggttgt ccagatcggc gaacatggcc gtggtggagc ggattgcttc
    21061 gacgtcgctc atccccaccc tgcgacccgc cgatccatcc ggaagctggg ccggactgga
    21121 cagcagccat ccgaaggccg cttgcgtgag ggcccctaca tccaccgtgc ttcgcaggaa
    21181 ttctcgccgc tgcgcgtcag cggtgaccaa ctgagccaac gtgtcgacga gatcggcggg
    21241 gacatcagag aagttgagcc cgatctcggg tgagacagtg gtgccctcca gcccgatgtc
    21301 cgccagggtg acccggcgac cgagcttgcg gctgagtgct tcagcgatca gagcagcggt
    21361 gatacctcgc ggcttctggc cttcgatcca ccgtgcgatc tgcgtatgcg agggccgcac
    21421 aggcacgcgc cattccttgg cgacctggcc gatgcggctg gccaggccga ggtgggagac
    21481 accggcctgg tcgacgacgt cggcgagccg ggcgttgggc tgacgctcca tatagcgcag
    21541 cgtagttgcg cgccgcctct gcggtaaggc catgacggtg agcagggcgg aatgcacagg
    21601 ggtttgcaca gatgcagacc cagtgagcgc tcccatctgc tgtggtgcgg cgatgtctac
    21661 ggcgtgatct ccttgacttc agcaacgcgg gctgagggcc gaggttcaat cgggtgccag
    21721 agcgggtgat ctttagggct gcctggggtt gctaacggtt acgtgatcgg gttcaaacca
    21781 ctaacgccac gctaacgaac gatcaagggc ctgatcgctg tctccagcga tcaggccctt
    21841 gacctgcaat ttccgagtcg gggtggcggg atttgaaccc acggcctctt cgtcccgaac
    21901 gaagcgcgct gccaagctgc gctacacccc ggtcgcttgg acttttcgtc ctgcgcctcg
    21961 gcaagtctag cggactttgc ggccgcttgt gccatcagac gcgaccggcc ggcgggggac
    22021 gagggtcagg agggtcgcct cgggtgggca ggcgaaacgc gcgggcgcgt acggggaggt
    22081 gccgaggccg gccgagacgt gcagccagga gctctcgtgc ctgctcagcc ccttgacgcg
    22141 ggcgcggtcg atgccgcagt tggtgaccag ggcgccgtag aacgggatgc agagctggcc
    22201 gccgtgggtg tggccggcca ggagcagttg gtacccgtcc tcggcgaagc gcgacatgtt
    22261 gcgcggctcg ggcgagtgca tgacgcccag ccgcaggtcg gcgtcggagg gggccggtcc
    22321 ggcgatctcg tcgtagcggt cccggtcgat gtgtgagtcg tcgatcccgc cgacgtggac
    22381 gtcgaggtcg gccaccttca ggcgggccgt cgtgttgttc atgtccagcc agccggcctc
    22441 ccgcatcgcg gcgcccagct cctcccaggg caggctcggc acgtgctgct cggagtctcc
    22501 cttcgacgta cgccagaggt agcgcacagg gttcttcggc cggggggcgt agaggtcgtt
    22561 ggagccgtag acgaacaggc ccggccggtc gagcagcgga tccacggcac gcatgtacgc
    22621 ctcgaccgcg tcggggtgcg ccagcgtgtc gccggtgttc acgacgagat cggggttgag
    22681 cgacgccaac gaccgaaccc acctgatcag ccggtcgcga cggggggtga gatgcaggtc
    22741 ggagatctgc aggatccgga ccggccgctg cccgggagcg agaacgggga cgtcgaaccg
    22801 gcgcagccgg aaccagttcc gctcgatcac ggcggcgtaa ccggcaccgg cgacgccgag
    22861 gccgagcact gacaggggaa tcgcggcggc tttcctcaca cagccatgat gcccgacctt
    22921 cgcgccgcct cccgcataac ctggcgaaga ccgggccccc ggcacggcaa gatgggacgc
    22981 atgagtgcgt tgaaggacaa gctgaaggcc gacctcgcgg cctcgatgaa ggctcgtgac
    23041 gaggtgcgcc tccggacgat ccggatggcg ctggcggcgg tgaacgtcga ggaggtcgcc
    23101 ggcaaggagg cccgcgagct cagcgacgac gaggtggtca agatcctgac ccgcgaggcc
    23161 aagaagcgcc gcgaggcctc cgaggcgttc gcgggcgccg gccgggccga gcaggcgcag
    23221 gcggagctgg acgagcaggc ggtgctggag gagtaccttc ccgcccagct cagcgatgac
    23281 gagctgaacg cgctcgtcga cgaggcgatc gcggagagcg gcgcgcaggg ccccaaggcg
    23341 atgggtcagg tcatgaaggt cctgaacccg aaggtcgcgg gccgggccga gggcggccgc
    23401 gtcgcccagg ccgtacgcgc ccgtctctcc gcctgaccac cgggacgccg ggaccggtgg
    23461 cctccgccgg agtgtcctgg agactggagt gtcttgggag gccggagggc ccctgtacgc
    23521 cgatgggcca cgcctcggac agaggagcgg cccaccggag gggacgccgg tcgagggcct
    23581 ccatcggagg cctcgaccgg ccgagcctca gttgaagggg tcgaacggct ggtttccgaa
    23641 cggccggtcg cccggcccgc ggccaccgcc acggccgccg tccccgccac cggggccacc
    23701 gccgtggccg ccgccgaagc cgcccggctc cggcttgggc ttgggcggcg gcgcgcactg
    23761 gtgggcgcag ccgccgaacc gcgacatgtc cggcttggtg aacgacgacg gatccacacc
    23821 cttgagcgcc gacaggaacg tcgccttcca gatcgggccg gggatggtgg cgccgaagac
    23881 cgagctgtac gtccggcctc ccatcacctg gccggggagc ggataccgca tcgggccgcg
    23941 cgggtcgccg aggctgaccg cgcccgcgag gtcgggagtg aagccggcga accagacggt
    24001 gcgggactgg tcgccggtgc cggtcttgcc cgcggcgtcc cggccgatgc cgccgacgcc
    24061 cgacatggtg cccttggtga acacgcccga caggatgtgg gtgaccgcgt ccgcgacctc
    24121 ggtctcgatg gcctgcttgc aggacggctt gaacgaggtc accttgttga agcggtcggt
    24181 gatctcggtg atagccatgg gcttgcagta cttgccgcgc gccccgatgg ccgcgtaggc
    24241 gctggcgacg gtcaccgggt ccatctcgtt gaagccgagc gtgaacgtct ggaactcgcg
    24301 cagcttgtcg ccgtcggccc gcttgatgcc gaggtccttg gcggtcttga cgacgtcaca
    24361 gagcccgacg cgctgctcca gggccatgaa gaaggtgttg accgacttcc aggtgcccga
    24421 ctgcagggtc aggaacccgc cgctgccgcc ctcggagttg tgctggatgc cccgggggtc
    24481 gccaacgagg ttcccgtcgc agtccttgaa ggccgaaggg ccgctcgcct ggaaggtcgc
    24541 gccggtgttg atgccgtcgt tgaacttgta gccctccttc agcgcggtga tcagcgtgaa
    24601 gaccttgaac gtcgatcccg cctggaagcc ggcgccgccg ccgtgcagcg cgtcggccac
    24661 gacgttgatc gacatctcgt tcttcttctt gctggtgccg aacttccggc tggcggccat
    24721 cgccttgatg gcgcccgtgc ccggctcgac gagcgcctcg gaggcgaccg gcttgtcgga
    24781 ggggtggacg tacttcttga tcgccttctc ggcggccttc tgcatcttcc ggctcagggt
    24841 ggtcctgatc gtcaggcccc ctcgtgccag gaagtcctgc cgggccttct tggacttgcc
    24901 gaactgcgcg tcgttgagga tctcgttgcg cacgtagagg cagaagtacg ggtagtcgct
    24961 ctcctcgcag ccgccgggga tctccttgtc cttccacccc agcttcttct tcttggccgc
    25021 gtcgcgctcg gcctctgtga cgatcttcaa ctcggccatc cggtcgagca ccacgttgcg
    25081 ccgggccatc agcctgtcgc ggaacgtctt gccccggttg ggg
//
