LOCUS       NZ_VYTZ01000005        25258 bp    DNA     linear   CON 20-NOV-2024
DEFINITION  Microbispora cellulosiformans strain Gxj-6 Scaffold5, whole genome
            shotgun sequence.
ACCESSION   NZ_VYTZ01000005
VERSION     NZ_VYTZ01000005.1
KEYWORDS    WGS; RefSeq.
SOURCE      Microbispora cellulosiformans
  ORGANISM  Microbispora cellulosiformans
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Streptosporangiales; Streptosporangiaceae; Microbispora.
REFERENCE   1  (bases 1 to 646337)
  AUTHORS   Gong,X.
  TITLE     Screening of Novel Bioactive Compounds from Soil-Associated
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 646337)
  AUTHORS   Gong,X.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-SEP-2019) College of Land and Environment, Shenyang
            Agricultural University, No. 120, Dongling Road, Shenhe District,
            Shenyang, Liao Ning 110866, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 2.04 OR JUL-2018
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 400x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_008728085.1-RS_2024_11_18
            Annotation Date                   :: 11/18/2024 02:05:44
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,471
            CDSs (total)                      :: 7,401
            Genes (coding)                    :: 7,312
            CDSs (with protein)               :: 7,312
            Genes (RNA)                       :: 70
            rRNAs                             :: 5, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 1 (5S, 16S)
            partial rRNAs                     :: 3, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 89
            CDSs (without protein)            :: 89
            Pseudo Genes (ambiguous residues) :: 0 of 89
            Pseudo Genes (frameshifted)       :: 7 of 89
            Pseudo Genes (incomplete)         :: 80 of 89
            Pseudo Genes (internal stop)      :: 8 of 89
            Pseudo Genes (multiple problems)  :: 6 of 89
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 09:06:26
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 436502
            Orig. end                         :: 461760
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            VYTZ01000005.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..25258
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="2"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..25258
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25258
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:15258](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..15258
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    115..129
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: medium, score: 19.02"
                     /tool="antismash"
     misc_feature    complement(510..525)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 20.68"
                     /tool="antismash"
     gene            528..1445
                     /locus_tag="F5972_RS16235"
                     /old_locus_tag="F5972_16235"
     CDS             528..1445
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0006865 - amino acid transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1096: polar amino
                     acid ABC transporter, inner membrane"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012892066.1"
                     /locus_tag="F5972_RS16235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F5972_16235"
                     /product="amino acid ABC transporter permease"
                     /protein_id="WP_150934311.1"
                     /transl_table=11
                     /translation="MEVTQEKAPAAELPIDAVRPARPGRWLGAAAALLFLVWLAYTVIV
                     NENLHWDVIVAYLADGRILGGLWVTIQLTVLSMAIGLALGVLAAVMQLSDNPVLRGTSA
                     LYTWFFRGTPLLVQLIFWFNIGLVFPTFAIGVPFGGPKLIEWQANAIITPFTAALLGLA
                     INEGAYMAEIVRAGIRSVDPGQREAAESLGMSHRQVLRRVVLPQAMRVIIPPTGNQFIS
                     MLKTTSMVSVIAGAELLTVAQRIYLGNFEVIAMLVVASIWYVVLTTIASVGQHFVEKRF
                     ERGHVRLSSRVRRNLRPVTSKEPS"
     gene            1475..2227
                     /locus_tag="F5972_RS16240"
                     /old_locus_tag="F5972_16240"
     CDS             1475..2227
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020541200.1"
                     /locus_tag="F5972_RS16240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F5972_16240"
                     /product="amino acid ABC transporter ATP-binding protein"
                     /protein_id="WP_150934540.1"
                     /transl_table=11
                     /translation="MVRIRAARKRFGPLEVLKGIDLDVPAGSVVCVVGPSGSGKSTLLR
                     CVNRLETIDSGRIWVNGELMGYNERGGRLHALRPAELSRQQRGIGMVFQRFHLFPHRTA
                     IENVMEGPVTVLRTPTAQARRQAAELLERVGLADRAHHYPAQLSGGQQQRVAIARSLAM
                     RPSLMLFDEPTSALDPELVQEVLAVMRDLAASGMTMMVVTHEMSFAREVGDQLVFMDDG
                     VIVERGDPREVLAAPRHDRLRAFLGQVL"
     gene            2334..4052
                     /locus_tag="F5972_RS16245"
                     /old_locus_tag="F5972_16245"
     CDS             2334..4052
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012892064.1"
                     /locus_tag="F5972_RS16245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F5972_16245"
                     /product="amidohydrolase family protein"
                     /protein_id="WP_150934312.1"
                     /transl_table=11
                     /translation="MTGTPRFDLLVRGGLVVDGTGRPARPADVGVSGGRLTVLPRDSSP
                     GSASGSVSGSVSGSVSRSVADAAEVLDARGRVVSPGFVDVHTHSDGVALLGAPGGGDGS
                     GGVSDRVSGGDSGRELVRASVLQGVTTEICGNCGSSLFPALPERLAAMRAETRITFGGD
                     VGAYADFAGFAAAHGRVPRANHLASLVGHGTLRAGVLGPVDRPARPAELRAMCALLDAS
                     LAQGAAGLSTGLIYTPGSYAGTAEVVALAEVAARHGKPYVTHLRDEMSRVEEALEEAIE
                     ISRRSGAALHVSHHKTAGRYAWGRTERTLPRLAELRAGGMDVTCDVYPYTAGSTALAAM
                     LPPWANDGGLRALTARLGDPAQRDRMRRAIAEGVPGWENTVGNGGWDRISVACAPRHPR
                     AEGATIADLATAAGADPLDVAADLLVAEDGEVTIISHSMIEDDVRRVLAAPYAMIGSDG
                     VPKPGGRPHPRWAGTFPRVLGRYVRELGLLGLEEAVHKMTGMAAARFGLTGRGVIRDGA
                     HADLVVFDPAEVADLATFTEPLLPPTGVGAVVVGGAVVVRDGEETGARPGRVLAL"
     gene            4049..5026
                     /locus_tag="F5972_RS16250"
                     /old_locus_tag="F5972_16250"
     CDS             4049..5026
                     /GO_function="GO:0008800 - beta-lactamase activity
                     [Evidence IEA]"
                     /GO_process="GO:0030655 - beta-lactam antibiotic catabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="resistance (resist) ClassA"
                     /gene_kind="resistance"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020541198.1"
                     /locus_tag="F5972_RS16250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F5972_16250"
                     /product="serine hydrolase"
                     /protein_id="WP_225311537.1"
                     /transl_table=11
                     /translation="MNAGNAGNAGNAGNAGNAGDAVNPGGAVNAGDAIAGDGGGVPRDA
                     GPGDVSGTARGSLAELAAACPGTLAVCVPGLLGVNEDVVLPLASTGKVLLLAALAQDVA
                     AGAIDPAEPVGLLDEDYAGGSGLLTELSARRWTIGDLAVLTASVSDNTATNALLRRLGL
                     ARVDAAAAALGLAETRVHDRIREPRLPAHPPAFATGTARELAGLMRSVAYGREPWQRLL
                     LGWMACNTDRGLVPALLPHEPEDREPPRVLPYADGVWVANKTGTDAGTRADVGVIAAAR
                     WEGYAVLAHGPEGSEQALVRAVRQAGLAVAATVTATVTAAVAAQ"
     misc_feature    complement(5080..5095)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.11"
                     /tool="antismash"
     gene            5181..>6050
                     /locus_tag="F5972_RS16255"
                     /old_locus_tag="F5972_16255"
                     /pseudo=""
     CDS             5181..>6050
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF015431.5"
                     /locus_tag="F5972_RS16255"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="F5972_16255"
                     /product="LysR family transcriptional regulator"
                     /pseudo=""
                     /transl_table=11
                     /translation="MLSSHRLRVLLEVFRTGSIAGAAKTLRLSPSAVSHQLARLEEEAG
                     VGLVERAAHSLRLTAAGRRLAGRAQEVLDLIESAEKDLLAQARADAGQLRIGFFASAGY
                     RLLPMALSSFTARHPGVDLDLVLGQPHELLADVERGELDVLVVFEHALDPWKAPKGVEV
                     VHLFDEPQLLVMPLGHPAGHRPRVRLADLAGDPWITTFGTETPVSVLERASALEGFTPA
                     IRCRSDHYEVTLGLVRAGLGVALVPSLGVQGAAGVQVCQVEGPRLFRRVGAAIRPTNPN
                     PALRAFVGY"
     gene            complement(6147..6614)
                     /locus_tag="F5972_RS16260"
                     /old_locus_tag="F5972_16260"
     CDS             complement(6147..6614)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013131916.1"
                     /locus_tag="F5972_RS16260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F5972_16260"
                     /product="SPW repeat protein"
                     /protein_id="WP_150934313.1"
                     /transl_table=11
                     /translation="MVGPTGIERHPDIAELRQTYDRAGSTAPAQVLEGLSFLAGLYLAL
                     SPWIVGFFRFPGLTISNLITGLVISALALGLASAFGRTYGMGWLIPLLGVWALVSPWVV
                     RGGGEATTSTVWNNVVTGIVIFALGAAALGMAQVYRRHERGERSGHRLGNW"
     misc_feature    complement(6686..6699)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.21"
                     /tool="antismash"
     misc_feature    6720..6738
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 18.7"
                     /tool="antismash"
     gene            6827..7681
                     /locus_tag="F5972_RS16265"
                     /old_locus_tag="F5972_16265"
     CDS             6827..7681
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF038012.1"
                     /locus_tag="F5972_RS16265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F5972_16265"
                     /product="DMT family transporter"
                     /protein_id="WP_150934314.1"
                     /transl_table=11
                     /translation="MIAVVLAVLAAAANAVASVLQRRAARGMPPGEAFRLGLILHLLRS
                     SAWLGGIGALIAGFLLQAAALSSGGLALVQPLLVAELPITMLVAGWMFRARLSPMTWLA
                     IAALTAGLGGFLGAASPTPGDRLPGLLGWTISAGVTAGLVAGCVAVAIASGGATRAVLL
                     GVSAGLGFAYTAVLMKRTVEVLPDGLRALSGAWSLYAMVAAGLCSLFLLQNALHSGPLV
                     AVQPALTVTDPVASTAYGVALFGEGIRTGPWVLPELTGMALILYGSVLLSRHAPLRESV
                     GRP"
     gene            complement(7614..8954)
                     /locus_tag="F5972_RS38155"
     CDS             complement(7614..8954)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020540952.1"
                     /locus_tag="F5972_RS38155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MGDG synthase family glycosyltransferase"
                     /protein_id="WP_225311538.1"
                     /transl_table=11
                     /translation="MTPPAAKVLIVSASMGAGHDGVAAELARRLAAAGVRVAVVDVLAL
                     LPLRLGSALRWWYRTVMLRAPWLYALVYRIFFVSRRASSGRARGVSPLTVVAAAGLNRV
                     VRRLRPSLLVPVFHVAAQAAGHLRSRGRLTVPSVVVLTDFAAHRLWLHAGNDRYLCPDA
                     ATALAVTAATGRPAFRHAPIVRPGFAAGGAPGRGVHARLGLPGGDRIVLVGAGAWGVGR
                     VVRTARALCRPGPGDGSPESGRYVPVVLCGRGERLRRRLTRLFAETSGTEASGTETARA
                     GQAVGAKGVGDAAGAVEAGGTRSAPRPVGLALGWRDDLPGLLAAAYALVDNAAGLTCRE
                     AFAARTPVVTCLPIPGHGRDGVLAMARAGVSVHVRRPARLLRELDRLAPGSPARAALTT
                     RAEALFAAEPAEALLLRFARPDGAPVTVSRHSPAAARAATAARCRTG"
     misc_feature    8909..8929
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.73"
                     /tool="antismash"
     gene            9082..9792
                     /locus_tag="F5972_RS16275"
                     /old_locus_tag="F5972_16275"
     CDS             9082..9792
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1235: polysaccharide deacetylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019633007.1"
                     /locus_tag="F5972_RS16275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F5972_16275"
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="WP_150934315.1"
                     /transl_table=11
                     /translation="MRRRVAAAGAALLPVAAHVAPGAAWLPAVRRLLPALAGEGRPGHV
                     ALTFDDGPDPRSTPLFLDELARLGCRATFFMLGEMLDRHPGLGRSVARAGHEVAVHGWH
                     HVNALVARPGRVAAEMGRAARLVAEVTGARPAWYRPPYGVLSAEALLAAWRHRLRPVLW
                     TAWGEDWTRRATPESVLRTLAPGLRGGATLLLHDCDHTSAPGSWRSALGALPEVVGRCR
                     AAGLRIGPLGAHLL"
     misc_feature    9990..10004
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.84"
                     /tool="antismash"
     gene            10001..10852
                     /gene="hpnC"
                     /locus_tag="F5972_RS16280"
                     /old_locus_tag="F5972_16280"
     CDS             10001..10852
                     /EC_number="2.5.1.21"
                     /GO_function="GO:0004311 - farnesyltranstransferase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene="hpnC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019634148.1"
                     /locus_tag="F5972_RS16280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F5972_16280"
                     /product="squalene synthase HpnC"
                     /protein_id="WP_150934316.1"
                     /sec_met_domain="PT_phytoene_like (E-value: 1.5e-42,
                     bitscore: 141.0, seeds: 61, tool: rule-based-clusters)"
                     /sec_met_domain="phytoene_synt (E-value: 5.5e-40, bitscore:
                     132.5, seeds: 8, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAADVRDAARRENFPVASRLLPRGYRRDLMAVYGFARYVDDAGD
                     EADPAERPALLDAVEADLGRLYAGGVPRLPAVRALTPLVARRAVPSAPFLHLVEANRRD
                     QVVRRYDTFAQLLGYCELSANPVGRIVLHVFGLATPERARLSDLVCSALQVIEHCQDVA
                     EDHARGRVYLPADDLRRFGAGEADLAAAHASPRLRRVIALQARRAATLLDEGTPLLETL
                     RGFARAAVAGYVAGGRAQLVALERRRHDVLGGAPRARRHAVLREWARVLKEVDGDGSRR
                     DP"
     gene            10827..11981
                     /locus_tag="F5972_RS16285"
                     /old_locus_tag="F5972_16285"
     CDS             10827..11981
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020540950.1"
                     /locus_tag="F5972_RS16285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F5972_16285"
                     /product="squalene/phytoene synthase family protein"
                     /protein_id="WP_225311539.1"
                     /sec_met_domain="PT_phytoene_like (E-value: 8.9e-58,
                     bitscore: 191.0, seeds: 61, tool: rule-based-clusters)"
                     /sec_met_domain="phytoene_synt (E-value: 8.1e-37, bitscore:
                     122.1, seeds: 8, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVPGAIPDPVPEPLAGAASDLPAGRAPETGQVSTPGPVLVHVSR
                     AYGHCEHVVRTRARNFAYGIRLLPPPKRRALSTVYALARRIDDVGDEAGPVAERLERLE
                     QERRRLRALKKLPLDSAEPDFPGPDSLVPGSMAGGRMPADVAADPVMVALGDAAARFPL
                     PLEAFEELIDGCAADVAGARYRCHDDLVGYCRQVAGSIGRLSLGVFGLADGAPASGGER
                     TLRRAAARADALGVALQLTNILRDLREDRCADRIYLPADDLRRFGCTLGLSPRGDFTDP
                     PERLAGLIRFEAALALGWYAEGMRLIPLLDRRSAACTAAMAGIYRRLLGRIAADPARVL
                     AGRLSLAPWVKAMVAARALTGGAQGEPQGKSRGDAHGDAPGESR"
     gene            11978..13390
                     /gene="hpnE"
                     /locus_tag="F5972_RS16290"
                     /old_locus_tag="F5972_16290"
     CDS             11978..13390
                     /EC_number="1.17.8.1"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hpnE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020540955.1"
                     /locus_tag="F5972_RS16290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F5972_16290"
                     /product="hydroxysqualene dehydroxylase HpnE"
                     /protein_id="WP_150934317.1"
                     /sec_met_domain="DAO (E-value: 2.4e-08, bitscore: 29.1,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGPLHGLGGAVPPVAVIGGGLAGITAALAVAEAGWPVTLYEARP
                     RLGGATHSFARGGLTADNGQHVFLRCCTAYLGLLDRLGGTGRVRLQERFDVRVLTPHGE
                     RGRLRRAALPGPFHLLPALARYRLLSPADRLRAVRGALALRGLDPAAPALDRAALGGWL
                     ATRGQRETVRRALWDLFAVAALNIAADEAALGPAAMVFRTALLGRADAADIGVPSVPLG
                     ELHGGAALTAIARAGGTVRMPAKAEAILPAPPGLPGPSVLVGGARVETSAVVVAVPHGQ
                     AARLVPAEAAPDRDAWAGLGASPIVNVHVVYDRPVTSLPFAAVVGSPVQWIFDRTAAGG
                     LTRGQYLTVSVSAARHWIDVPTAAMRAAFVPELERLLPATRTVRLLDFFITRERRATFR
                     QGPGSGALRPAAATRWPGLFLAGAWTGTGWPDTMEGAVRSGLEAARLVRLHLSHLNHLG
                     HGREPARAGWAR"
     gene            13387..15258
                     /gene="shc"
                     /locus_tag="F5972_RS16295"
                     /old_locus_tag="F5972_16295"
     CDS             13387..15258
                     /EC_number="5.4.99.17"
                     /GO_function="GO:0016866 - intramolecular transferase
                     activity [Evidence IEA]"
                     /GO_function="GO:0051007 - squalene-hopene cyclase activity
                     [Evidence IEA]"
                     /GO_process="GO:0019746 - hopanoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="shc"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T2TS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020540957.1"
                     /locus_tag="F5972_RS16295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F5972_16295"
                     /product="squalene--hopene cyclase"
                     /protein_id="WP_150934318.1"
                     /sec_met_domain="T2TS (E-value: 9.5e-150, bitscore: 494.8,
                     seeds: 58, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTALVTAASRAATALEAARDHLLALQSPEGWWKGELQTNVTMDAE
                     DLLLREFLGVRTAAETAEAARWIRSQQQAGGGWANFHDGPADLSTTVEAYVALRLAGDP
                     PSAPHLRAAAGLVRDLGGVESARVFTRMWLALFGLWRWEDLPVIPPEIVFLPPWCPLNV
                     YDWACWARQTIVPLTIVTAHRPVRPLPFGLAELRTGRRPPSPPRTSVDTAFAALDHVLH
                     RYERRPLAGLRRAALRRAAEWVVARQEADGSWGGIQPPWVYSLVALHLSGYDAGHPVMR
                     RGLAGLDRFTIREDGSRRLEACQSPVWDTALAVIALLDAGLPRDHPALDRAGEWLLREE
                     IRGPGDWAVRRPGLAPGGWAFEFDNDGYPDVDDTAEVILALGRWGRPAARDAVRRGLRW
                     MAGMASRDGGFAAFDADNTRALCLRLPFCDFGAVIDPPSADVTAHVVEALAAEGEARSP
                     AVRRAVTWLLRAQEPGGSWFGRWGANHVYGTGAVLPALAAAGVPPAAPCVRRAVAWLEA
                     HQHPGGGWGEDMRSYRDPAWIGRGEPTASQTAWALIGLLAAGERGPSVERGVAWLAGTQ
                     RPDGTWDEPHYTGTGFPGDFYINYHLYRLVFPVSALGRYLQAREGTR"
     gene            15255..16802
                     /gene="ispH"
                     /locus_tag="F5972_RS16300"
                     /old_locus_tag="F5972_16300"
     CDS             15255..16802
                     /EC_number="1.17.7.4"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0051745 - 4-hydroxy-3-methylbut-2-enyl
                     diphosphate reductase activity [Evidence IEA]"
                     /GO_process="GO:0019288 - isopentenyl diphosphate
                     biosynthetic process, methylerythritol 4-phosphate pathway
                     [Evidence IEA]"
                     /GO_process="GO:0050992 - dimethylallyl diphosphate
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="ispH"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009076659.1"
                     /locus_tag="F5972_RS16300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F5972_16300"
                     /product="4-hydroxy-3-methylbut-2-enyl diphosphate
                     reductase"
                     /protein_id="WP_150934319.1"
                     /transl_table=11
                     /translation="MTDLIVCTALGMEARAVARGLRPVRERPRVRVVRVGMGPDRAARA
                     AALLPPAGALAVTGFAGALDDGLRPGDVLVATEVRSRVRSGDRVWPCPSAPLLAGELAR
                     AGLRVVTGPLVTSPRVVAGRDRRALAAEGAVAADMESAPLAAAARGRPFAAVRVIVDTP
                     ATPLLSLGTMGGAATACRTLARIGPVLARWAAATGPRRVLLASPRSFCAGVERAVEIVE
                     RALARYGPPVYVRKQIVHNAHVVRDLERRGAVFVDELAEVPDVPGGAVTVFSAHGVSPE
                     VREEAGRRGLRVVDATCPLVAKVHAEARRFAARGDLVVLIGHAGHEEVEGVLGELPGAG
                     VLAEDEAAVEALPASLAEGRGVACLTQTTLAADEAGEVAAAVRRRFPGAEGPRGDDICY
                     ATTNRQRAVRAVAAEAGLVLVVGSANSSNARRLTEVAARSGRDEAPLARLVDGPGDIAL
                     EWLRGARTVGLTASASTPASLVDAIVAALGGLGPLKVEERRVTEEDVEFTLPKEVRP"
     gene            16802..17806
                     /gene="hpnH"
                     /locus_tag="F5972_RS16305"
                     /old_locus_tag="F5972_16305"
     CDS             16802..17806
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hpnH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QueE"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020540959.1"
                     /locus_tag="F5972_RS16305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F5972_16305"
                     /product="adenosyl-hopene transferase HpnH"
                     /protein_id="WP_150934320.1"
                     /sec_met_domain="PF04055 (E-value: 4.3e-18, bitscore: 61.4,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="QueE (E-value: 6.9e-09, bitscore: 30.7,
                     seeds: 32, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPMPLRQSLRVGGYVLRQRLRRRRRFPLLVELEPLFACNLKCAGC
                     GKIQHPAGVLRQRMPVGQAVAAVEECGAPMVSIAGGEPLMHPQIAEMVRALVARRKYVF
                     LCTNALLIPRKIDQFTPSPYFAWAVHIDGLRERHDASVCKEGVFEQAVAAVRECRRRGF
                     RVTTNTTFFAGDSPRTVIEVLDYLNDDLRVDQMMISPGYAYEKAPDQDCFLGVRQTREL
                     FRAAFAGGNRGRWRLNHSPLYLDFLEGRIDFPCTAWAIPSYSVFGWQRPCYLMADGYAG
                     TYRELADETDWSAYGRGRDPRCANCMAHCGYEPTAVFATIGSLRESLRALRSP"
     misc_feature    16814..16816
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(17803..18534)
                     /locus_tag="F5972_RS16310"
                     /old_locus_tag="F5972_16310"
     CDS             complement(17803..18534)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (7-163). E-value: 8.5e-12. Score:
                     37.3. Matches aSDomain:
                     nrpspksdomains_F5972_RS16310_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020540960.1"
                     /locus_tag="F5972_RS16310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F5972_16310"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_150934321.1"
                     /transl_table=11
                     /translation="MRLAGARVLVTGASSGIGTAIALELWARRARLVLSGRDREALAAV
                     AARTGGEVVPADLAQDGTEELAARAGPVDVLVANAGEGWSGPLTRMPGGTAERLIAVNL
                     TAHVRLTRLLLPAMIERGRGHLVYVASIAGVVGVPEEAVYAATKAGLLAFAESLRYELP
                     GIGVTTVVPGVVDTPFFARRGTPYARRRPAPVPPERVARAVAVAVERGRAEVYMPAWLR
                     LPARLHGAAPGPFRALARRFG"
     aSDomain        complement(18046..18513)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_F5972_RS16310_PKS_KR.1"
                     /evalue="8.50E-12"
                     /label="F5972_RS16310_PKS_KR.1"
                     /locus_tag="F5972_RS16310"
                     /protein_end="163"
                     /protein_start="7"
                     /score="37.3"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VLVTGASSGIGTAIALELWARRARLVLSGRDREALAAVAARTGGE
                     VVPADLAQDGTEELAARAGPVDVLVANAGEGWSGPLTRMPGGTAERLIAVNLTAHVRLT
                     RLLLPAMIERGRGHLVYVASIAGVVGVPEEAVYAATKAGLLAFAESLRYELP"
     CDS_motif       complement(18424..18510)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_F5972_RS16310_0001"
                     /evalue="4.60E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="F5972_RS16310"
                     /protein_end="37"
                     /protein_start="8"
                     /score="16.1"
                     /tool="antismash"
                     /translation="LVTGASSGIGTAIALELWARRARLVLSGR"
     gene            18711..19298
                     /locus_tag="F5972_RS16315"
                     /old_locus_tag="F5972_16315"
     CDS             18711..19298
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012893363.1"
                     /locus_tag="F5972_RS16315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F5972_16315"
                     /product="hypothetical protein"
                     /protein_id="WP_150934322.1"
                     /transl_table=11
                     /translation="MATGTASTLRSPGLLPALNTRHHRAALGVFAFVVVAHWAEHIAQA
                     VQVYVLGWPLPEARGVLGLPFPWLVTSEWMHYGYALLMLAGLLMLRRGFTGRARTWWNV
                     ALGIQVWHHFEHLLLLVQATTGDNLLGRPVPTSIIQLLVPRMELHLFYNTLVTIPMVVA
                     MILHRRPTTAERAAMRCSCAPRPAARPREAMA"
     gene            19295..19831
                     /locus_tag="F5972_RS37275"
     CDS             19295..19831
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="F5972_RS37275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_191910154.1"
                     /transl_table=11
                     /translation="MTAGPGPRRGSPAFTAALTLFALFLLFLAVPGIGPAVRAARADGV
                     PGTFTARSVACVEHPGHESCTWNGDFRSDDGAVRRDGVELYGADHDMLREGQETRAVDV
                     GRPSRVYGPGGSMEWVFTALLLLAAGGILLVAYGGPVRRLLHARTSGRAGAHSGAHSGA
                     PSGAPDSGGVPSHSR"
     gene            19828..20559
                     /locus_tag="F5972_RS16320"
                     /old_locus_tag="F5972_16320"
     CDS             19828..20559
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024863.5"
                     /locus_tag="F5972_RS16320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F5972_16320"
                     /product="GDSL-type esterase/lipase family protein"
                     /protein_id="WP_191910155.1"
                     /transl_table=11
                     /translation="MTQPTSRPMTCPATIMVVGDSLSHGSDGDYTWRYRLARHFAARGA
                     PVRFTGPWTGTRAPPRAHRSPPHAHRSPVGGYRPGIGFPGDRHYARWGRLMEEARRNIA
                     DAVAAHRPGHLLVALGFNDLAWGVSGPDRLLAHVAEFVDRARAVRPDLRFLVADVVHRT
                     PLPSLSHLPGITEAYNARLPGLLAALSTPRSPVVPVGLAAVYDPYADTYDGLHPGLAGE
                     FTIAKAFAGAFLPALVAGRAG"
     gene            complement(20495..21022)
                     /locus_tag="F5972_RS16325"
                     /old_locus_tag="F5972_16325"
     CDS             complement(20495..21022)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015925.5"
                     /locus_tag="F5972_RS16325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F5972_16325"
                     /product="antibiotic biosynthesis monooxygenase"
                     /protein_id="WP_191910156.1"
                     /transl_table=11
                     /translation="MLVGAPPAHRAVTVGIAHRVTRSAEPAFLRWQEKVRKVREKFPGF
                     LGFELFRPVPGLQGDWVSVFRFDTREHLESWLGSQARRTLLDEGRGIIASYDVRRIDSA
                     FSGWFRFTGDSARGAGPPGWKQAMSVILGLYPVLIVLGSPAGRPGGAEDRLSRPARRRG
                     RGGTRPRRPSRS"
     misc_feature    complement(21158..21173)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.36"
                     /tool="antismash"
     misc_feature    21170..21183
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 12.54"
                     /tool="antismash"
     gene            21531..21764
                     /locus_tag="F5972_RS16335"
                     /old_locus_tag="F5972_16335"
     CDS             21531..21764
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="F5972_RS16335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="F5972_16335"
                     /product="hypothetical protein"
                     /protein_id="WP_117410272.1"
                     /transl_table=11
                     /translation="MTKKITISLPDELADEAQASGNASAYIAAALRERRRVQGDLAIMA
                     DLWGPGWQDGITDDDSARAARLMGGDAKADAA"
     misc_feature    21669..21671
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            21761..22210
                     /locus_tag="F5972_RS16340"
                     /old_locus_tag="F5972_16340"
     CDS             21761..22210
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="F5972_RS16340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="F5972_16340"
                     /product="type II toxin-antitoxin system VapC family toxin"
                     /protein_id="WP_150934326.1"
                     /transl_table=11
                     /translation="MTDPVPPAGVLSGHVLDLDAVVHLIEGKSMYGRAVVRQSSAHGVT
                     LLVPALAVQVLSLGPIQPRLERFLRMSMVVTGALSPDDAVEGGPYAQAIRASLRRHRPA
                     AADARLADVLVAAHAVVHATRRDWRIITPSPYLYEGLDVRLEILP"
     gene            complement(22207..22803)
                     /locus_tag="F5972_RS16345"
                     /old_locus_tag="F5972_16345"
     CDS             complement(22207..22803)
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020545579.1"
                     /locus_tag="F5972_RS16345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F5972_16345"
                     /product="response regulator transcription factor"
                     /protein_id="WP_150934327.1"
                     /transl_table=11
                     /translation="MIVDDHPVVRDGLRGMFDHVADIEVVAEASDGFEALALARSARPH
                     VVLMDLRMPGLDGVGAIQRLRESHPEIKVVVLTTYDTDADVARAMAAGVAGYLLKDAPR
                     EELHRAVRTAAAGGAVLAPSVASALMSRPAAPDPSPRELEVLRLVARGSANKEIARTLL
                     ISETTVKTHLKHVFAKLGVESRAAAVVVAMERGLI"
     gene            complement(22803..23900)
                     /locus_tag="F5972_RS16350"
                     /old_locus_tag="F5972_16350"
     CDS             complement(22803..23900)
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020545580.1"
                     /locus_tag="F5972_RS16350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F5972_16350"
                     /product="sensor histidine kinase"
                     /protein_id="WP_150934328.1"
                     /transl_table=11
                     /translation="MNVWEARWLRAFHLLYYACLALGLILSYGDGTGGGTGPGPLTPAI
                     VALMAGWHGFFVVRRPRLLGRLNPMAFHLAVVCALYILLVSRDRSFDVVVFGLMPQPYL
                     MLASPWSYVGAVATVLSTFAARGYLDGPDVLWGLVGSSGLVVAIGLFVDYVSRQSAQNR
                     TFGVLEERARLAREIHDTLAQGLSGIVTQLEAAEQAMPDLRVVQERIALAKELARDNLQ
                     EARRSVDALRPGPLAGAGLEAALAEVAARWSRTSGVAPVVSVEGTPRPLSGEVGATLLR
                     TAQEGLANAAKHAKAGRVAITLTYMDDEVTLDVFDDGVGFDPDVRGAGYGLAAMRERAG
                     GVGGTLTVESAPGEGTALCLRIPSN"
     gene            complement(23905..24594)
                     /locus_tag="F5972_RS16355"
                     /old_locus_tag="F5972_16355"
     CDS             complement(23905..24594)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1065: ABC-2 type
                     transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020545581.1"
                     /locus_tag="F5972_RS16355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F5972_16355"
                     /product="ABC transporter permease"
                     /protein_id="WP_150934329.1"
                     /transl_table=11
                     /translation="MKAFTALAAAELRLLSRDPASLFFMVAFPLMLLVLKRGDSGAVPG
                     YLAMIAAIGGMGALPGLLASYRERKVLKRLATTPISPVLLLGAQLVAQVAAGLAGSVLL
                     VVVTIAVFGARAPGDVFLLTAAFLLCSVMACALGFVIAAVVRTARGASLIGMLVMFPMI
                     FLSGAAVPRRALPGSLRQIGDFLPLTPAVEALGGAWSGTAASFPLLILAGIIVAATAAG
                     AALFRWE"
     misc_feature    complement(25153..25168)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.68"
                     /tool="antismash"
ORIGIN
        1 gacatcgtga tgtcctcgat gagcgacacc gaggagcggc gcgcggccgt cgacttcgtc
       61 gactacttca acgccggcgg cgcgatcatg gtcaagaagg gcaaccccga ggggatcaag
      121 accctcgatg acctgtgcgg ccgtacggtc gtgctggcca agggcagctc caacctcgcc
      181 atcggcgaga agcagaacga gaagtgcgcc accaagatga agatcatgca gagcgaggac
      241 gcgcccaccg gcctgctctc gatcgactcc gggcgcgcca ccgcgaccat cgtggactac
      301 cccgtcgccg tcatgtacgc caaggacacc ggcaagtacg acgtgctgtc cgagcagtac
      361 gacgccgggc cgtggggcat cgcgatcgac aagcgcaaga ccgcgctgcg cgacgcggtc
      421 gccaaggcca tggaggagct tcaggccgac ggcggctaca aggccgtgct ggacagctac
      481 ggcgtgacgg ccaacgccgt cgacggcgta ctggtcaaca ccaagccgtg gaagtgacgc
      541 aggagaaggc gcccgccgcc gaactgccga tcgacgccgt gcgccccgcg cggcccggcc
      601 ggtggctcgg cgcggcggcc gccctgctct tcctcgtgtg gctggcctac acggtcatcg
      661 tcaacgagaa cctgcactgg gacgtcatcg tcgcctacct ggccgacggc aggatcctcg
      721 gcggcctgtg ggtgaccatc cagctcaccg tgctgtccat ggccatcggc ctcgcgctgg
      781 gcgtgctcgc cgccgtcatg cagctgtcgg acaaccccgt gctgcgcggc acctccgcgc
      841 tctacacgtg gttcttccgc ggcacgccgc tgctggtgca gctgatcttc tggttcaaca
      901 tcgggctggt cttccccacc ttcgcgatcg gcgtcccgtt cggcgggccc aagctgatcg
      961 agtggcaggc gaacgcgatc atcacgccgt tcaccgcggc gctgctcggc ctggcgatca
     1021 acgagggcgc gtacatggcg gagatcgtcc gcgccggcat ccgctcggtg gacccgggcc
     1081 agcgggaggc cgccgagtcg ctcggcatgt cgcaccggca ggtgctgcgc cgcgtggtgc
     1141 tgccgcaggc catgcgggtg atcatcccgc cgaccggcaa ccagttcatc tccatgctga
     1201 agaccacgtc gatggtctcg gtcatcgccg gggccgagct gctcaccgtg gcgcagcgca
     1261 tctacctcgg caacttcgag gtcatcgcga tgctcgtcgt cgcgtcgatc tggtatgtcg
     1321 tgctcaccac gatcgcgagc gtcggccagc acttcgtcga gaagcggttc gagcgcggcc
     1381 acgtgcggct gtcctcccgc gtacgccgca acctgcggcc cgtgacgtcc aaggagccct
     1441 cgtgagcacg cccgaagcac cggccgaccg gccgatggtg cggatccgcg ccgcgcgcaa
     1501 gcggttcggc ccgctggagg tgctcaaggg catcgacctc gacgtccccg ccggctcggt
     1561 ggtctgcgtc gtcgggccgt ccgggtcggg caagtcgacg ctgctgcgct gcgtcaaccg
     1621 cctggagacg atcgactccg gccgcatctg ggtgaacggc gagctgatgg gctacaacga
     1681 gcgcggcggg cggctgcacg cgctgcgccc ggccgagctg tcccgccagc agcgcggcat
     1741 cggcatggtg ttccagcggt tccacctgtt cccgcaccgc accgcgatcg agaacgtcat
     1801 ggaggggccc gtcaccgtgc tccgcacgcc caccgcgcag gcccggcggc aggcggcgga
     1861 actgctggag cgggtcggcc tggccgaccg cgcgcaccac tacccggcgc agctgtcggg
     1921 cggccagcag cagcgcgtgg cgatcgcccg cagcctggcc atgcggccca gcctgatgct
     1981 gttcgacgag ccgaccagcg cgctcgaccc cgagctcgtg caggaggtgc tcgccgtcat
     2041 gcgggacctc gcggccagcg gcatgacgat gatggtcgtc acccacgaga tgagcttcgc
     2101 ccgcgaggtc ggcgaccagc tcgtcttcat ggacgacggc gtcatcgtgg agcggggcga
     2161 cccgcgcgag gtgctcgcgg cgccccggca cgaccggctg cgcgccttcc tgggacaggt
     2221 cctgtgagcc cggccgcggc cgctcgtacg ggacggcccg ccgggcggcg tgccgcggcc
     2281 ccggagatct cggggacagg ggcggggacg gatcgggtga cgaggaggct tccgtgacgg
     2341 ggacgccccg cttcgacctc ctcgtccggg gcgggctggt ggtcgacggc accggccgcc
     2401 cggcccggcc cgccgacgtc ggggtctccg gcgggcggct gaccgtgctt ccccgggact
     2461 cgtcgccggg ttcggcgtcg ggctctgttt cgggctctgt ttcgggctct gtgtcgcgct
     2521 ctgtggccga cgccgccgag gtgctcgacg cgcgcgggcg ggtcgtctcc cccggcttcg
     2581 tcgacgtcca cacgcactcc gacggcgtcg ccctgctcgg cgcgcccggc ggcggcgacg
     2641 ggtccggcgg cgtttccgac agggtttccg gcggtgattc cggccgggag ctggtgcggg
     2701 cctcggtgct gcagggggtc accaccgaga tctgcggcaa ctgcgggtcg agcctgttcc
     2761 cggccctgcc ggagcggctg gccgccatgc gggccgagac ccggatcacc ttcggcggcg
     2821 acgtcggcgc gtacgccgac ttcgcggggt tcgccgccgc gcacggccgg gtgccccggg
     2881 ccaaccacct ggcctcgctc gtcggccacg gcacgctccg ggcgggcgtg ctcggcccgg
     2941 tggaccggcc cgcccggccc gcggagctgc gcgcgatgtg cgcgctgctc gacgcgtccc
     3001 tggcgcaggg cgccgccggc ctgtccaccg gcctcatcta cacccccggc tcgtacgccg
     3061 gcaccgccga ggtggtggcg ctggcggagg tggccgcccg gcacggcaag ccgtacgtga
     3121 cccacctgcg agacgagatg tcacgcgtgg aggaggcgct ggaggaggcg atcgagatct
     3181 cccggcgcag cggcgcggcg ctgcacgtgt cgcaccacaa gaccgccggg cggtacgcct
     3241 ggggccgcac cgagcgcacg ctgccgcgcc tcgcggaact gcgtgcgggc ggcatggacg
     3301 tcacctgcga cgtctacccc tacacggcgg gcagcacggc gctggccgcg atgctgccgc
     3361 cgtgggcgaa cgacggcggg ctccgcgccc tgaccgcgag gctcggcgac cccgcccagc
     3421 gcgaccggat gcgccgggcc atcgccgagg gcgtgcccgg ctgggagaac acggtcggca
     3481 acggcggctg ggaccggatc tcggtggcct gcgcgccccg tcatccgcgg gccgagggcg
     3541 cgacgatcgc cgacctcgcc accgccgcgg gggccgatcc cctcgatgtg gccgccgacc
     3601 tgctggtcgc cgaggacggc gaggtgacga tcatcagtca ttccatgatc gaggatgacg
     3661 tgcggcgggt gctggccgcg ccgtacgcga tgatcggctc cgacggcgtg ccgaagcccg
     3721 gcgggcgccc gcacccgcgc tgggccggga ccttcccccg ggtgctcggc cggtacgtac
     3781 gcgagctcgg gctgctcggc ctggaggagg cggtgcacaa gatgaccggg atggcggcgg
     3841 cccgcttcgg cctgaccggg cggggcgtga tccgcgacgg cgcgcacgcc gacctggtgg
     3901 tgttcgaccc ggcggaggtc gccgacctgg ccaccttcac cgagccgctg ctgccgccca
     3961 cgggcgtcgg cgcggtggtg gtcggcggcg cggtcgtggt gcgcgacggc gaggagacgg
     4021 gcgcccgccc gggacgggtg ctggcgctgt gaacgccggg aacgccggga acgccgggaa
     4081 cgccgggaac gcggggaacg ccggagacgc tgtgaaccct gggggcgcgg tgaacgccgg
     4141 ggacgcgatc gccggggacg ggggcggggt cccccgcgac gccgggccgg gggacgtctc
     4201 cggcaccgcg cgcggctcgc tggcggagct ggcggcggcc tgccccggga cgctggccgt
     4261 gtgcgtcccc ggcctgctcg gggtgaacga ggacgtggtg ctgccgctgg ccagcaccgg
     4321 caaggtgctg ctgctcgcgg cgctcgcgca ggacgtcgcg gccggcgcga tcgacccggc
     4381 cgagccggtc gggctgctcg acgaggacta cgcggggggt tcgggcctgc tcaccgagct
     4441 gtcggcccgc cgctggacca tcggcgacct cgccgtgctg accgcgtccg tcagcgacaa
     4501 cacggcgacg aacgcgctgc tgcggcggct cgggctcgcc cgggtggacg ccgctgccgc
     4561 cgcgctcggg ctggccgaaa cccgcgtcca cgacaggatc cgggagccgc gactgcccgc
     4621 gcacccgccc gcgttcgcca ccgggacggc ccgcgagctc gccggcctca tgcggtccgt
     4681 ggcgtacggc cgggagccgt ggcagcggct gctgctcggc tggatggcct gcaacacgga
     4741 ccgcggcctg gtcccggcgc tgctgccgca cgagccggag gaccgcgagc cgccgcgcgt
     4801 gctgccgtac gccgacgggg tgtgggtggc gaacaagacc ggcacggacg ccgggacgcg
     4861 ggccgacgtc ggcgtgatcg cggcggcccg gtgggagggc tacgcggtgc tcgcgcacgg
     4921 gccggaaggc tccgagcagg ccctcgtgcg ggccgtgcga caggccggcc tcgccgtggc
     4981 cgccacggtg accgccacgg tgaccgccgc agtggccgcc cagtgaccgc caccgcggcc
     5041 gcgaccgccg ccgccacgat gaccggcccg gaacccaccg ggaccggcgg gtgaccggca
     5101 ggaccggcac tgcgccggct gggtgatcgc cgcctccgct cgggcgtgac cagcgcggac
     5161 gcggcccgat actggggggc atgctcagca gccaccgcct cagggtgctc ctggaggtct
     5221 tcaggaccgg gagcatcgcc ggagccgcca agaccctgcg gctgtcgccg tccgccgtct
     5281 cgcaccagct cgcccggctg gaggaggagg cgggggtcgg gctggtggag cgggccgcgc
     5341 acagcctgcg gctgaccgcc gccggccgcc gcctggccgg gcgggcccag gaggtgctcg
     5401 atctcatcga gtccgccgag aaggacctgc tcgcgcaggc gcgggcggac gccgggcagc
     5461 tccggatcgg gttcttcgcc tcggccggct accggctgct gccgatggcg ctgtcgtcgt
     5521 tcacggcccg ccaccccggc gtcgatctcg acctcgtgct cgggcagccg cacgagctgc
     5581 tagccgatgt ggagcgcggt gagctcgacg tgctggtcgt gttcgagcac gcgctcgacc
     5641 cctggaaggc gccgaagggc gtggaggtcg tccacctctt cgacgagccg cagcttttgg
     5701 tcatgccgct gggccatccc gccggacacc ggccccgcgt acggctggcc gacctcgccg
     5761 gcgatccgtg gatcaccacg ttcggcaccg agaccccggt gtcggtgctg gagcgggcca
     5821 gcgccctgga gggcttcacc cccgcgatcc gctgccgcag cgaccactac gaggtgacgc
     5881 tcggcctggt gcgggccggg ctgggggtgg ccctggtgcc gagcctcggt gtgcagggcg
     5941 cggcgggcgt ccaggtgtgc caggtggagg gcccccggct cttccgccgg gtcggcgccg
     6001 cgatccggcc gaccaatccc aaccccgccc tgcgggcctt cgtcggctat ctcagggacg
     6061 cctcggcccg cctcagcgtg acgctccgcc agaccacgac gtccgagcgg cccgccgcgc
     6121 ggagcggcgg gccgccggac ggccggtcac cagttgccga gccggtgccc gctccgctcg
     6181 ccccgctcgt gccggcggta gacctgcgcc atgcccagcg cggcggcgcc gagcgcgaag
     6241 atcacgatgc cggtcacgac gttgttccag acggtgctgg tggtggcctc gcctcccccg
     6301 cgcaccaccc agggcgagac cagcgcccac acgccgagta gcgggatcag ccaccccatg
     6361 ccgtaggtgc gtccgaaggc ggacgcgagc ccgagggcca gggcactgat cacgaggccc
     6421 gtgatcaggt tgctgatggt cagcccgggg aagcgaaaga acccgacgat ccagggcgag
     6481 agcgccagat aaagacccgc caggaaggac agcccttcca gtacctgcgc gggagccgtc
     6541 gaacccgccc ggtcgtaggt ctggcgcagt tcggcgatgt cggggtgacg ctcgatgccg
     6601 gtaggtccaa ccatgactgg tcccgccttt cctgctggtt gcgtttgcgc ggacggccat
     6661 acccccacaa atcgcacaat tctccatttt gcgtaatatc tcgctgattg tttgctttta
     6721 gcaggataaa ttgccattcg gggattcgct ggaagatagc ggcagattcg gccggggagg
     6781 gtaccgatga ggtccggccg agggtgcgca gacggggagg ggggtcatga tcgctgttgt
     6841 ccttgccgtg cttgccgcgg cggccaacgc cgtcgcgtcg gtgctgcagc gccgggccgc
     6901 ccgcggcatg ccccccggcg aggccttccg gctggggctg atcctgcacc tgctgcgcag
     6961 ttccgcctgg ctgggcggca tcggggcgct gatcgcgggg ttcctgctgc aggccgccgc
     7021 gctctcgtcc ggagggctcg ccctcgtgca gcccctgctc gtcgcggaac tgccgatcac
     7081 gatgctggtg gcgggctgga tgttccgggc ccgcctctcc ccgatgacgt ggctggccat
     7141 cgcggcgctc acggcagggc tgggcgggtt cctgggggcg gcctccccca ctccgggcga
     7201 ccgcctgccg ggcctgctgg gctggacgat ctcggccggt gtgaccgccg ggctcgtggc
     7261 cggctgcgtg gcggtcgcga tcgcctccgg cggcgccacc cgcgccgtgc tgctcggggt
     7321 ctccgccggg ctcgggttcg cctacaccgc cgtgctgatg aagcgcaccg tcgaggtgct
     7381 gcccgacggg ctgcgggccc tgtccggcgc ctggtcgctg tacgccatgg tggccgccgg
     7441 cctgtgcagc ctgttcctgc tgcagaacgc cctgcacagc ggccctctcg tcgccgtgca
     7501 gccggcgctg accgtgaccg accccgtcgc cagcacggcg tacggcgtgg ccctgttcgg
     7561 cgagggcatc cgcaccggcc cgtgggtgct gccggagctg accggtatgg ccctcatcct
     7621 gtacggcagc gtgctgctgt cgcggcacgc gccgctgcgg gagagtgtcg ggagaccgtg
     7681 acgggcgcgc cgtccggccg cgcgaagcgg agcagcaggg cctccgccgg ctcggcggcg
     7741 aacagcgcct ccgcgcgggt ggtcagcgcg gcccgggcgg gcgagccggg ggcgagccgg
     7801 tcgagttccc ggagcagccg ggcgggacgg cgcacgtgga cgctcacccc ggcgcgggcc
     7861 atcgcgagca ccccgtccct gccgtgaccg gggatcggca ggcaggtcac gacgggcgtc
     7921 cgcgcggcga acgcctcccg gcaggtcagc ccggcggcgt tgtccaccag cgcgtacgcc
     7981 gcggcgagca ggccgggcag gtcgtcgcgc cacccgaggg cgagccccac cggccgcggc
     8041 gccgaccgcg ttccgccggc ctccacggct ccggcggcat cgcccacgcc tttcgcacct
     8101 accgcctgtc cggccctcgc cgtctccgtc ccgctcgcct ctgtcccgct cgtctccgcg
     8161 aacaggcgcg tcaggcggcg gcgtagccgc tcgccccgcc cgcacagcac gacgggcacg
     8221 taccgcccgc tctccggcga gccgtctcca ggtccggggc ggcacagggc gcgggccgtc
     8281 cgcacgaccc ggccgactcc ccacgcgccc gcgccgacca gcacgatccg gtcgccgccg
     8341 ggcagtccca gccgggcgtg gacgcctcgt cccggcgctc ccccggcggc gaacccgggc
     8401 cgcacgatcg gggcgtgccg gaaggccgga cggccggtgg cggcagtcac ggcgagggcg
     8461 gtggccgcgt ccgggcacag gtaccggtcg ttgcccgcgt gcagccagag gcggtgcgcg
     8521 gcgaagtcgg tcagcacgac cacgctgggg accgtcagcc gcccccggga ccgcaggtgc
     8581 cccgcggcct gggcggcgac gtggaagacc ggcaccagca gcgagggccg caggcggcgc
     8641 accacccggt tcagcccggc cgccgccacg accgtcagcg gcgagacccc gcgagcccgc
     8701 ccagaggacg cgcgccgcga cacgaagaag atccggtaga cgagggcgta cagccatggg
     8761 gcccggagca tcacggtgcg gtaccaccag cgcagggccg accccagccg cagcggcagc
     8821 agagcgagca cgtccacgac cgccacccgg acaccggcgg cggcgaggcg gcgggccagt
     8881 tcggcggcca cgccgtcgtg accggccccc atcgacgcgc tgacgatcag caccttcgcc
     8941 gccggcggtg tcatgggccc ctcccagcga gtggacgacg acgcggcgag gcgccggacg
     9001 ccgtctcctg ctctcgttcc cggcccggcg actccggaca ccgaggcata tatagattca
     9061 gatcgggcga taatggaccc gatgagacgt cgcgtggccg ccgccggagc ggcgctgctg
     9121 cccgtcgcgg cgcacgtcgc gccgggcgcg gcctggctgc ccgccgtccg ccgcctgctg
     9181 cccgccctcg cgggcgaggg gcgtcccggg cacgtcgcgc tgaccttcga tgacgggccc
     9241 gatccccggt cgactccgct gttcctcgac gaactcgcgc ggctcggctg ccgggcgacg
     9301 ttcttcatgc tgggcgagat gctcgaccgc catcccggcc tcgggcggag cgtcgcgcgg
     9361 gccgggcacg aggtggccgt gcacggctgg caccacgtga acgccctggt cgcccggccg
     9421 ggccgggtcg cggcggagat gggccgcgcc gcacgccttg tcgccgaggt caccggcgcg
     9481 cggcccgcct ggtaccgccc gccgtacggc gtgctgagcg ccgaggcgct gctggcggcg
     9541 tggcggcacc gcctgcgccc ggtgctgtgg acggcgtggg gcgaggactg gacgcgccgg
     9601 gccacgccgg agtcggtgct gcggaccctg gcgcccggcc tgcggggcgg cgccacgctg
     9661 ctgctgcacg actgcgacca cacctccgcc cccgggtcgt ggcgctcggc gctcggcgcg
     9721 ctgcccgagg tggtcggccg ctgccgcgcc gccggtctgc ggatcgggcc gctcggcgcc
     9781 cacctcctgt gatccttcgg aagagctttg ccggcggccg gaagcgccaa cggcgggcaa
     9841 cggttccgcc ggtccccgac ggctcctccg ggcgtttctt tggcccgcct ttccgtccgc
     9901 cctcgtccgt gtacgccggg ttgcccgtcc ggtcacccac gcaaagccgc cgcccgatct
     9961 gtcgggtttt ggggggattt tcgatggaga ttctccagac atgtccgcag cggacgtacg
    10021 cgacgccgca cgccgggaga acttcccggt ggcctcccgg ctgctgccgc gcgggtaccg
    10081 ccgcgacctc atggcggtgt acgggttcgc ccgatacgtg gacgacgccg gtgacgaggc
    10141 ggacccggcg gagcggcccg ccctgctcga cgccgtcgag gccgacctcg gccgcctgta
    10201 cgcgggcggc gtcccgcgcc tgccggccgt acgcgcgctg acgccgctgg tcgcccgccg
    10261 ggccgtgccg agcgctccgt tcctgcacct ggtcgaggcg aaccggcgtg accaggtggt
    10321 gcggcgctac gacacgttcg cccagctgct gggctactgc gagctgtcgg ccaacccggt
    10381 cggccggatc gtgctgcacg tgttcgggct ggcgacgccc gagcgggcac ggctgtccga
    10441 cctcgtctgc tcggcgctcc aggtgatcga gcactgccag gacgtggccg aggaccacgc
    10501 ccgcggccgc gtctacctcc cggcggacga cctgcgcagg ttcggcgccg gagaggccga
    10561 cctggccgcc gcgcacgcct ccccgcggct gcgccgggtc atcgccctgc aggcccgccg
    10621 cgcggccacc ctgctcgacg aggggacgcc gctgctggag accctgcgcg ggttcgcgcg
    10681 cgcggcggtg gccggctacg tcgcgggtgg ccgggcgcag ctcgtggcgc tcgaacgccg
    10741 ccggcacgac gtgctgggcg gcgccccgcg tgcccgccgc cacgcggtgc tgcgggagtg
    10801 ggcgcgtgtg ctgaaggagg tggacggtga cggttcccgg cgcgatccct gatcccgtcc
    10861 ccgagcccct ggccggcgcg gcgtcggacc ttccggccgg gcgggcgccg gagaccggtc
    10921 aagtgtcgac gccggggccg gtgctggtgc acgtgtcgcg ggcctacggg cactgcgagc
    10981 acgtcgtccg cacccgggcg cggaacttcg cgtacggcat ccgcctgctg cccccgccga
    11041 agcggcgcgc gctcagcacc gtctacgcgc tcgcccggcg gatcgacgac gtcggcgacg
    11101 aggccgggcc cgtggccgaa cgactggagc ggctggagca ggagcgcagg cggctgcgcg
    11161 ccctcaaaaa gctgcctctc gattccgcgg agcccgattt cccgggccct gattccctgg
    11221 tgcctggttc gatggccggc ggacgcatgc ccgccgacgt ggcggccgat cccgtgatgg
    11281 tggcgctggg cgacgccgcg gcgcgcttcc cccttcccct tgaggcgttc gaggagctca
    11341 tcgacggatg cgccgccgac gtcgccgggg cgcgttaccg atgccacgac gacctggtgg
    11401 gctactgccg gcaggtggcc gggtcgatcg ggcggctgtc gctcggcgtg ttcggcctcg
    11461 ccgacggcgc gcccgcgagc ggcggcgagc ggacgctgcg gcgcgcggcg gcccgggcgg
    11521 acgccctcgg cgtggcgctg cagctcacca acatcctcag ggacctgcgg gaggaccgct
    11581 gcgccgaccg catctacctg cccgccgacg acctgcgcag gttcggctgc acactcgggc
    11641 tgagcccgag gggagacttc acggacccgc ccgagcggct ggccgggctg atccggttcg
    11701 aggccgcact ggcgctcggc tggtacgccg agggcatgcg gctgatcccg ctgctcgacc
    11761 ggcgcagcgc cgcctgcacc gcggcgatgg ccggcatcta ccggcgcctg ctggggcgga
    11821 tcgccgccga tccggcccgg gtcctggccg ggcggctgtc gctcgcgccg tgggtcaagg
    11881 cgatggtcgc ggcccgcgcc ctcacgggcg gggcccaggg agagccgcag gggaagtcac
    11941 ggggagacgc acacggggac gcacccggag agtcccgatg acgggccccc tgcacggcct
    12001 gggcggcgcg gtcccgcccg tggcggtgat cggcggcggc ctcgccggga tcaccgcggc
    12061 cctggccgtc gcggaggccg gctggccggt gaccctgtac gaggcccggc cccggctcgg
    12121 cggggccacc cactccttcg cccgcggcgg cctgacggcc gacaacggcc agcacgtctt
    12181 cctgcgctgc tgcacggcgt acctcggcct gctcgaccgg ctcggcggga ccgggagggt
    12241 gcgcctgcag gagcgcttcg acgtgcgcgt gctgactccg cacggcgagc gggggcggct
    12301 gcgccgggcc gcgctgcccg ggccgttcca cctgctcccc gcgctcgcgc gctaccggct
    12361 gctgtccccc gccgaccgcc tgcgggcggt gcgcggcgcg ctggcgctgc gcgggctcga
    12421 cccggccgcg cccgcgctgg accgggccgc gctcggcggc tggctggcca cccggggcca
    12481 gcgggagacc gtgcggcgcg ccctgtggga cctgttcgcg gtggccgcgc tcaacatcgc
    12541 cgccgacgag gcggcgctcg ggcccgcggc catggtgttc cgtacggccc tgctcggccg
    12601 cgccgacgcc gcggacatcg gcgtgccgtc cgtgccgctc ggggaactgc acggcggcgc
    12661 ggcgctgacc gccatcgcgc gggccggcgg cacggtgcgg atgccggcga aggccgaggc
    12721 gatcctgccg gccccgcccg gcctgccggg gccgtcggtc ctcgtcggcg gcgcacgggt
    12781 ggagacctcc gccgtcgtcg tcgccgtccc ccacgggcag gccgcgcggc tcgtgccggc
    12841 cgaggcggcg ccggaccgcg acgcgtgggc ggggctcggg gcgagcccga tcgtcaacgt
    12901 gcacgtcgtc tacgaccggc cggtcaccag cctgccgttc gccgcggtcg tcggctctcc
    12961 ggtgcagtgg atcttcgacc ggacggcggc gggcgggctg acccggggtc agtacctgac
    13021 ggtgtcggtg tcggcggccc ggcactggat cgacgtgccc acggccgcga tgcgcgccgc
    13081 gttcgtgccg gagctggagc ggctgctccc ggccacgcgg acggtgcggc tgctcgactt
    13141 cttcatcacc agggaacggc gggcgacctt ccgccagggc ccggggagcg gcgcgctgcg
    13201 ccccgcggcg gccacccggt ggccggggct gttcctggcc ggcgcctgga ccggcaccgg
    13261 ctggcccgac acgatggagg gcgccgtgcg cagcggcctg gaggcggccc gcctggtgcg
    13321 gctgcacctc agccatctca accacctcgg ccacggcagg gagcccgcgc gagcggggtg
    13381 ggcgcgatga ccgcactcgt caccgccgcg tcccgcgccg cgaccgcgct cgaagcggcc
    13441 cgcgaccacc tgctcgccct gcagtcgccg gagggctggt ggaagggcga gctccagacc
    13501 aacgtgacca tggacgccga ggacctcctg ctccgcgagt tcctcggcgt gcggaccgcg
    13561 gccgagacgg ccgaggccgc ccggtggatc aggtcgcagc agcaggcggg cggcggctgg
    13621 gccaacttcc acgacggtcc ggccgacctg agcaccaccg tcgaggcgta cgtcgcgctg
    13681 cggctcgcgg gcgacccgcc gtccgcgccg cacctgcgcg ccgcggcggg cctcgtacgc
    13741 gatctgggcg gcgtcgagtc ggcccgggtc ttcacccgga tgtggctcgc gctgttcggc
    13801 ctgtggcggt gggaggacct gccggtgatc cccccggaga tcgtgttcct gcccccgtgg
    13861 tgcccgctga acgtgtacga ctgggcctgc tgggcgcggc agacgatcgt gccgctgacg
    13921 atcgtgaccg cgcaccggcc ggtccgcccg ctgccgttcg gcctggcgga actgcgcacc
    13981 gggcggcgcc cgccgtcgcc cccgcgtacg agcgtggaca cggcgttcgc ggcgctcgac
    14041 cacgtgctgc accgctacga acggcggccg ctcgccgggc tccgccgcgc cgcgctccgg
    14101 cgggcggccg agtgggtcgt cgcccggcag gaggccgacg ggtcgtgggg cggcatccag
    14161 ccgccctggg tctactcgct ggtcgcgctg cacctctccg ggtacgacgc cgggcacccc
    14221 gtcatgcgcc gggggctggc cgggctggac cggttcacga tcagggagga cggctcgcgc
    14281 aggctggagg cgtgccagtc gccggtctgg gacaccgcgc tcgccgtgat cgccctcctg
    14341 gacgccggcc tgccgcgcga tcacccggcg ctggaccggg cgggtgagtg gctgctccgc
    14401 gaggagatcc gggggcccgg cgactgggcc gtgcgtcgcc cggggctcgc ccccggcggc
    14461 tgggcgttcg agttcgacaa cgacggctat cccgacgtcg acgacacggc ggaggtgatc
    14521 ctcgcgctgg gccggtgggg ccgtccggcc gcccgggacg ccgtacggcg gggcctgcgc
    14581 tggatggccg ggatggcctc ccgcgacggc ggcttcgccg cgttcgacgc cgacaacaca
    14641 cgcgcgctgt gcctgcgact gccgttctgt gacttcggcg cggtcatcga cccgccgtcg
    14701 gccgacgtga cggcgcacgt ggtcgaggcc ctcgccgccg agggcgaggc ccgctccccc
    14761 gccgtacggc gggccgtgac gtggctgctg cgggcgcagg agcccggcgg ctcgtggttc
    14821 ggcaggtggg gggcgaacca cgtgtacggc accggggcgg tgctgcccgc cctcgccgcc
    14881 gccggggtgc cgcccgccgc gccctgcgta cggcgcgcgg tcgcctggct ggaggcgcac
    14941 cagcaccccg gcggcggctg gggcgaggac atgcgctcct accgcgaccc cgcctggatc
    15001 gggcggggcg agccgaccgc ctcgcagacc gcctgggcgc tcatcggcct gctggccgcc
    15061 ggagagcggg gcccgtccgt cgagcgcggc gtcgcctggc tggccggcac gcagcgcccg
    15121 gacggcacct gggacgagcc gcactacacc gggaccggct tccccggcga cttctacatc
    15181 aactaccacc tctaccggct cgtgttcccg gtcagcgcgc tcggccgcta cctacaggcc
    15241 cgggagggga ctcgatgacg gatctgatcg tgtgcaccgc gctcggcatg gaggcccggg
    15301 ccgtggcccg ggggctgcgg ccggtgcggg agcgtccccg cgtccgggtc gtccgggtcg
    15361 gcatggggcc cgaccgggcg gcgcgcgcgg cggccctgct cccgcccgcc ggcgccctcg
    15421 ccgtcaccgg cttcgcgggc gccctggacg acgggctgcg ccccggggac gtgctcgtcg
    15481 ccaccgaggt ccgctccagg gtccgctccg gggaccgcgt gtggccgtgc ccctccgccc
    15541 cgctgctcgc cggcgaactg gcccgcgccg ggctgcgcgt cgtcaccggc ccgctcgtga
    15601 cctcccctcg cgtcgtcgcg ggccgcgacc gccgcgcgct tgccgccgag ggggcggtcg
    15661 cggccgacat ggagagcgcg ccgctggccg ccgccgcgcg ggggcggccc ttcgccgccg
    15721 tacgcgtgat cgtggacacc cccgccaccc ccctgctgag cctcgggaca atgggcggtg
    15781 cggccacggc gtgccggacg cttgcccgga tcggcccggt gctggcgcgg tgggcggcgg
    15841 ccacgggccc ccggcgggtg ctgctcgcct ccccccgctc gttctgcgcg ggggtcgagc
    15901 gcgccgtcga gatcgtggag cgggcgctcg cccggtacgg cccgccggtg tacgtgcgca
    15961 agcagatcgt gcacaacgcc cacgtcgtac gggacctgga gcggcgcgga gcggtgttcg
    16021 tggacgagct ggccgaggtg cccgacgtgc ccgggggcgc ggtgaccgtg ttctccgcac
    16081 acggggtgtc ccccgaggtg cgtgaggagg ccgggcggcg cggcctgcgg gtggtcgacg
    16141 cgacgtgccc gctggtcgcg aaggtccacg cggaggcccg ccggttcgcc gcccggggcg
    16201 acctcgtcgt gctgatcggc cacgccgggc acgaggaggt ggagggcgtg ctcggcgagc
    16261 tgcccggcgc gggggtgctg gccgaggacg aggccgcggt cgaggccctg cccgcgtcgc
    16321 tcgccgaggg gcgcggggtc gcctgcctga cacagaccac gctggccgcc gacgaggccg
    16381 gggaggtcgc ggcggcggtc cggcggcgct tccccggggc ggaagggccg cgaggcgacg
    16441 acatctgcta cgcgacgacc aaccggcagc gcgcggtgcg ggcggtggcc gccgaggccg
    16501 ggctggtcct ggtcgtcggg tcggcgaact cgtccaacgc ccggcggctg accgaggtcg
    16561 ccgcccgttc gggtcgtgat gaggctcccc tcgcccggct ggtcgacggc ccgggcgaca
    16621 tcgcgctgga gtggctgcgc ggcgcgcgga cggtcgggct gaccgcgagc gcgtccaccc
    16681 ccgcctcgct ggtggacgcc atcgtggcgg ccctcggcgg gctcgggccg ctgaaggtgg
    16741 aggaacggcg ggtgaccgag gaggacgtcg agttcacact gccgaaggag gtgcggccct
    16801 gatgccgatg cccttacgtc agagccttcg cgtgggcggg tacgtcctgc gccagcggtt
    16861 gcggcggcgc agacggttcc cgctgctggt ggagctggag ccgttgttcg cctgcaacct
    16921 caagtgcgcg ggctgcggga agatccagca cccggccggc gtgctcaggc agcgcatgcc
    16981 ggtcggccag gcggtcgccg ccgtcgagga gtgcggcgcg ccgatggtgt ccatcgccgg
    17041 cggggagccg ctcatgcacc cccagatcgc ggagatggtc cgggcgctgg tggcccggcg
    17101 gaagtacgtc ttcctgtgca ccaacgccct gctgatcccg cgcaagatcg accagttcac
    17161 gccctcgccg tacttcgcct gggcggtgca catcgacggg ctgcgcgagc ggcacgacgc
    17221 gtcggtgtgc aaggagggcg tgttcgaaca ggcggtcgcg gcggtgcggg agtgccggcg
    17281 gcgcggcttc cgcgtcacca ccaacaccac cttcttcgcc ggggacagcc cgcgcacggt
    17341 gatcgaggtg ctcgactacc tgaacgacga cctgcgggtc gaccagatga tgatctcgcc
    17401 ggggtacgcg tacgagaagg cccccgacca ggactgcttc ctcggggtgc ggcagacccg
    17461 cgagctgttc cgcgcggcct tcgccggagg caaccggggg cgctggcggc tgaaccactc
    17521 gccgctctac ctggacttcc tggaggggag gatcgacttc ccctgcacgg cctgggccat
    17581 cccgtcgtac tcggtcttcg gctggcagcg gccctgctat ctgatggcgg acgggtacgc
    17641 cgggacctac cgggagctgg ccgacgagac cgactggagc gcctacgggc ggggccgcga
    17701 cccgcgctgc gccaactgca tggcgcactg cggctacgag ccgacggcgg tcttcgccac
    17761 catcggctcg ctgcgcgagt ccctgcgcgc gctgcgcagc ccctagccga agcggcgggc
    17821 gagggcgcgg aacgggccgg gcgcggcgcc gtgcaggcgg gcgggcagcc gcagccaggc
    17881 cggcatgtac acctcggcgc ggccgcgctc gacggcgacc gcgacggccc gcgccacccg
    17941 ctccggcggc acgggcgccg gccggcggcg cgcgtacggc gtgccgcgcc gcgcgaagaa
    18001 cggcgtgtcg accaccccgg gcaccacggt ggtcaccccg atcccgggca gctcgtagcg
    18061 caggctctcg gcgaaggcca gcaggcccgc cttggtcgcg gcgtagaccg cctcctccgg
    18121 gacccccacc acccccgcga tcgaggcgac gtagacgagg tgcccgcgcc cgcgctcgat
    18181 catcgcgggc agcagcagcc gggtgagccg cacgtgggcc gtcaggttga ccgcgatcag
    18241 gcgttccgct gtgccgcccg gcatccgcgt cagcggcccg ctccagccct cgcccgcgtt
    18301 cgcgaccagc acgtccaccg gcccggcgcg cgccgccagt tcctcggtcc cgtcctgtgc
    18361 gaggtcggcg gggacgacct cgccgccggt ccgggcggcg acggcggcga gcgcctcccg
    18421 gtcgcgcccg gacagcacca ggcgggcgcg gcgggcccac agttcgagcg cgatcgccgt
    18481 gccgatgccc gacgacgcgc ccgtgacgag cacccgtgcc cccgccagcc gcatccgtcc
    18541 tccccccttc tgtggctgta cccgcggacg cggcgtccca cggctgcaga agacgccgca
    18601 cggcgggaga agcggcccgc ggccgccgga tcgcaccatg ggacgtacgg gctcgcgatc
    18661 cgtaccgggc cctcaggtca ggtcacaggc tcccggatcg aggttctcgc atggcgaccg
    18721 gaacggcttc cacactgcga tcgcccggcc tgctgccggc gctcaacacc cgccaccatc
    18781 gcgccgctct cggggtcttc gcgttcgtcg tcgtggccca ctgggccgag cacatcgccc
    18841 aggcggtgca ggtctacgtg ctcggctggc cgctccccga ggcgcgcggc gtgctcggcc
    18901 tgccgttccc atggctggtg acgtccgaat ggatgcacta cggctacgcg ctgctgatgc
    18961 tggccggcct gctcatgctg cggcgcggct tcaccggccg ggcccgcacc tggtggaacg
    19021 tcgcgctcgg catccaggtc tggcaccact tcgagcacct gctgctgctc gtgcaggcga
    19081 cgacgggcga caacctgctg ggccggcccg tgccgaccag catcatccag cttctggtgc
    19141 cgcgcatgga actgcacctg ttctacaaca ccctcgtcac gatcccgatg gtggtcgcga
    19201 tgatcctgca ccgccgtccc accaccgccg agcgggccgc gatgcgctgc tcctgcgccc
    19261 cgcgccccgc ggcgcggcca cgagaggcca tggcgtgacg gcgggccccg ggccgcgccg
    19321 cggctccccc gccttcaccg ccgcgctcac gcttttcgcc ctcttcctgc tcttcctggc
    19381 cgtgcccggc atcggaccgg ccgtacgggc cgcccgcgca gacggcgtcc ccggcacctt
    19441 caccgcccgc tcggtcgcct gcgtggagca ccccggccac gaatcctgca cctggaacgg
    19501 cgacttccgc tccgacgacg gcgccgtacg gcgcgacggc gtcgaactgt acggcgccga
    19561 ccacgacatg ctgcgggagg ggcaggagac ccgggccgtg gacgtggggc ggccgagccg
    19621 ggtctacggc cccggtggtt ccatggaatg ggtgttcacc gcgctgctgc tgctcgccgc
    19681 gggcggcatc ctgctcgtcg cgtacggcgg accggtgcgg cgcctgctcc acgcccgcac
    19741 gagcggccga gctggggctc acagtggggc tcacagtggg gctcccagcg gggcgccgga
    19801 ctccggaggc gtgccatccc acagccgatg acgcagccga cgtcgcggcc gatgacgtgc
    19861 ccggccacca tcatggtggt gggcgactcg ctcagccacg gctcggacgg cgactacacg
    19921 tggcggtacc ggctcgcccg ccacttcgcc gcgcgcggcg cgccggtgcg cttcaccggg
    19981 ccgtggacgg gcacccgcgc cccgccccgt gcgcaccgct ccccgcctca tgcgcaccgc
    20041 tccccggtgg gcggctaccg cccggggatc ggcttccccg gcgaccggca ctacgcccgc
    20101 tggggccgcc tcatggagga ggccaggcgg aacatcgcgg acgccgtcgc cgcgcaccgg
    20161 cccggccacc tattggtcgc gctcggcttc aacgacctgg cctggggcgt gagcggcccc
    20221 gaccgcctgc tcgcccacgt cgcggagttc gtggaccggg cccgcgccgt gcggccggac
    20281 ctgcggttcc tcgtggccga cgtggtccat cgcacgccgc tgccctccct gtcgcatctg
    20341 ccggggatca ccgaggcgta caacgcccgg ctgcccggcc tcctggccgc cctgtccacg
    20401 ccgcgctccc ccgtcgtccc cgtggggctg gccgccgtct acgacccgta cgccgacacc
    20461 tacgacggcc tgcaccccgg cctcgccggc gagttcacga tcgcgaaggc cttcgcgggc
    20521 gcgttcctcc ccgccctcgt cgccgggcgg gccggctgag ccggtcttca gcgccgcccg
    20581 gccgtccagc cggcgatccg agcacgatga gcaccggata gagcccgagg atcaccgaca
    20641 tggcctgttt ccagccgggc gggccggcgc ctcgcgccga atctccggtg aaccggaacc
    20701 agccgctgaa cgccgaatcg attcggcgca catcgtagga ggcgatgatt ccgcggccct
    20761 cgtcgagcag cgtcctcctc gcctgggagc cgagccagct ctccaggtgt tcccgcgtgt
    20821 cgaagcggaa gacggagacc cagtcgccct ggagccccgg caccggccgg aagagctcga
    20881 accccaggaa accggggaac ttctcccgca ccttccgcac cttctcctgc cagcggagaa
    20941 acgccggttc cgcactccgg gtgacgcgat gggcgatccc caccgtcacc gcccgatgcg
    21001 ccggaggcgc gccgaccagc acctcctggt cctcgggccg ggcgagcagg ccccttccct
    21061 cctccagcag ccgcctccgc cggggcgcag gcttcgggct gttccgttct cgcgaaacgg
    21121 aaaacgacca cccattctcc cgccatgccg tcgccgggcg gataaatctc tttgtccatg
    21181 aaaccggcaa aacctcgcgc cagcccggtc aattcttcct gccaacgccg gtagtcgctc
    21241 tcacgccctt tcgcactttc tgcgtgatga gaacggtccc gctttcatcc ccgtggtgtg
    21301 gaagcggtga tcaccctgcc ggagggcgcg gagatgaccg cccgggacgg agcggccggc
    21361 ccggcggaga ctggcagcag tacctcgcga acccgctcga cgagatcaag gcggaactcc
    21421 gcgcgctcag cgagcggatc gcgaatctgg agagcaggaa ggtctgagcc gcgcggcttt
    21481 tcccgcgaac cggtggacca ccgacggtat gactcagtag ccttccgagt atgaccaaga
    21541 agattacgat ctctttgccg gacgaactgg ccgacgaggc gcaggcgtcc ggcaacgcct
    21601 cggcctacat cgccgcggcg ctgcgcgagc ggcggcgcgt ccagggcgac ctggccatca
    21661 tggccgattt atggggtccg ggctggcagg acggcatcac cgacgacgac agcgcccgcg
    21721 cggcccgcct catgggcggg gacgccaagg cggacgccgc gtgaccgacc ccgtcccacc
    21781 ggccggcgtc ctgtccggcc acgtgctgga cctcgacgcc gtcgtccacc tgatcgaggg
    21841 caagagcatg tacggcaggg cggtcgtgcg gcagtcctcc gcgcacggcg tcaccctcct
    21901 cgttcccgcg ctcgccgtcc aggtcctctc gctgggcccc atccagcccc gcctcgaacg
    21961 cttcctgcgc atgtcgatgg tcgtcaccgg cgcgctgtcg cccgacgacg ccgtcgaggg
    22021 cgggccgtac gcacaggcga tcagggcgag cctgcgccgg caccggcccg cggcggccga
    22081 cgcgcgcctg gccgacgtgc tcgtggccgc acacgccgtc gtccacgcca cccgccgcga
    22141 ctggcggatc atcaccccgt ccccctacct gtacgagggc ctggacgtcc gcctggagat
    22201 cctcccctag atgagccctc gctccatggc cacgacgacg gccgcggccc tgctctcgac
    22261 accgagtttg gcgaagacgt gcttgagatg cgtcttcacc gtcgtctcgc tgatcagtag
    22321 ggtcctggcg atctccttgt tcgccgaccc ccgcgccacc aggcgcagca cctccagctc
    22381 gcgcgggctc ggatccgggg ccgcgggcct gctcatcagg gcggacgcga ccgacggcgc
    22441 caggaccgct ccgccggcgg cggccgtacg gaccgctctg tgcagttcct cgcgtggcgc
    22501 gtccttcagg aggtagcccg ccaccccggc ggccatggcc cgggccacgt ccgcatccgt
    22561 gtcgtaggtg gtcagcacga ccaccttgat ctccgggtgg ctctcccgga gccgttggat
    22621 cgccccgaca ccgtccagac cgggcatgcg aaggtccatc agcaccacgt gcggccgcgc
    22681 gctcctggcc agggccagcg cctcgaaccc gtcggacgcc tccgccacca cctcgatgtc
    22741 cgccacgtgg tcgaacatgc cgcgcagtcc gtcgcggacc accggatggt catcgacgat
    22801 catcaatttg aggggatgcg caggcacagg gccgtcccct cccccggtgc ggactccacg
    22861 gtcagcgttc ccccgacgcc gccggcccgc tcccgcatgg ccgccagccc gtagcccgcg
    22921 ccacgcacgt ccggatcgaa acccaccccg tcgtcgaaca cgtcgagcgt cacctcatcg
    22981 tccatgtagg tcagcgtgat cgcgaccctg cccgccttgg catgcttggc cgcgttcgcc
    23041 agcccttcct gcgccgtacg caggagcgtc gctcccacct cgccggacag cggccggggc
    23101 gtcccctcca ccgacacgac cggcgccacc cccgacgtcc gcgaccaccg tgcggccacc
    23161 tccgcgagcg ccgcctccag ccccgcgccg gcgagagggc ccggccgcag cgcgtcgacc
    23221 gagcgccgcg cctcctggag gttgtcgcgt gccagctcct tggccagcgc gatcctctct
    23281 tgcacgacgc gcaggtcggg catcgcctgc tcggccgcct ccaactgggt gacgatgccg
    23341 ctcaacccct gcgcgagggt gtcgtggatc tccctggcca gcctcgcccg ctcctccagc
    23401 accccgaagg tccggttctg cgcgctctgc cgggacacgt agtccacaaa cagtccgatc
    23461 gccacgacga gaccggagct cccgacgagc ccccacagga cgtcgggacc gtccagatag
    23521 cctctggcgg cgaacgtgct gaggaccgtc gccaccgccc ccacgtacga ccaggggctc
    23581 gccagcatca ggtacggctg gggcatcagc ccgaagacga ccacgtcgaa ggaccggtcc
    23641 cgcgacacca gcagaatgta gagcgcgcag acgaccgcca ggtggaacgc catggggttc
    23701 agccgcccga gcagccgcgg ccgccgtacg acgaagaagc cgtgccatcc ggccatgagc
    23761 gccacgattg ccggtgtgag cgggccgggg cccgtgcccc cgcccgtgcc gtccccgtac
    23821 gagaggatca gcccgagcgc cagacaggcg tagtacaaca ggtggaaggc gcgcaaccag
    23881 cgcgcctccc agacgttcac gtcatcactc ccatcggaac agcgcggcgc cggcggccgt
    23941 ggccgccacg attatcccgg ccaggatcag cagggggaag gacgccgcgg tgcccgacca
    24001 ggcgcctccc agggcttcca cggccggggt caggggcagg aagtcgccga tctgacgcaa
    24061 cgagccgggc agggccctcc tgggcacggc cgcgccggac aggaagatca tcgggaacat
    24121 gaccagcatg ccgatcaggc tcgcgcctct cgcggtgcgc acgacggcgg cgatcacgaa
    24181 gcccagcgcg caggccatca ccgagcagag caggaaggcg gcggtcagca ggaaaacgtc
    24241 gccgggtgcc cgcgcgccga acaccgcgat cgtcacgacc accagcagca cggagcccgc
    24301 caggcccgcg gcgacctggg ccaccagctg ggcgccgagc agcagaaccg gggagatcgg
    24361 cgtggtggcc agccgcttga gcaccttgcg ctcgcggtag gaggccagca ggcccggcag
    24421 cgcacccatc ccgccgatgg cggcgatcat cgcgaggtag ccggggaccg cgccgctgtc
    24481 gccgcgtttg agcaccagca gcatgagggg gaacgccacc atgaagaaca acgaggcggg
    24541 gtcgcgcgac agcagcctga gctcggcggc cgccagagcc gtgaacgcct tcatcggtcc
    24601 gttccctcca gggcgaggta ggcctcttcc agcgaggcgg ttccggtccg ggcgacgagc
    24661 tcgcccgtgg tgcccgccgc cgccacccgg ccgcgggcga agacggcgac ccggtcgcag
    24721 agcgcctcta tctcgtcgaa gtagtggctg accagcacca cggtggtgcc cgccgtcttc
    24781 aggtcgtgga ccagccgcca ggtctcgcgg cgcgcgatcg ggtcgagacc cgtggtcagc
    24841 tcgtcgagca cgaccatctc ggggtcgccg accagggcca gcgcgagcat cagccgctgt
    24901 ctctgcccgc ccgacagatc gccgaacgcc tttcccgcca gcggccgcag accccagcgc
    24961 tccatcaccc ccctccagcc ggacccgtcc cggtagaacg agccgaacat gcgcagcgcc
    25021 tcggccaccg tgatccgctc gggtagggag ctgtcctgca gttgcacgcc gagacggtga
    25081 gccagggctc tccgcctgcg cgccggatcc tcgccgagca cgcggaccgt gcccgcgtcg
    25141 gctcgcctga gtccgatcag gcactcgacg gtcgtggtct tcccggcgcc gttgcggccg
    25201 atgatcccga acgtctcacc ggaccggacc gtgaacgtca ccccgtccac ggcgcggg
//
