LOCUS       NZ_VYTZ01000004        21125 bp    DNA     linear   CON 20-NOV-2024
DEFINITION  Microbispora cellulosiformans strain Gxj-6 Scaffold4, whole genome
            shotgun sequence.
ACCESSION   NZ_VYTZ01000004
VERSION     NZ_VYTZ01000004.1
KEYWORDS    WGS; RefSeq.
SOURCE      Microbispora cellulosiformans
  ORGANISM  Microbispora cellulosiformans
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Streptosporangiales; Streptosporangiaceae; Microbispora.
REFERENCE   1  (bases 1 to 659004)
  AUTHORS   Gong,X.
  TITLE     Screening of Novel Bioactive Compounds from Soil-Associated
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 659004)
  AUTHORS   Gong,X.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-SEP-2019) College of Land and Environment, Shenyang
            Agricultural University, No. 120, Dongling Road, Shenhe District,
            Shenyang, Liao Ning 110866, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 2.04 OR JUL-2018
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 400x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_008728085.1-RS_2024_11_18
            Annotation Date                   :: 11/18/2024 02:05:44
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,471
            CDSs (total)                      :: 7,401
            Genes (coding)                    :: 7,312
            CDSs (with protein)               :: 7,312
            Genes (RNA)                       :: 70
            rRNAs                             :: 5, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 1 (5S, 16S)
            partial rRNAs                     :: 3, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 89
            CDSs (without protein)            :: 89
            Pseudo Genes (ambiguous residues) :: 0 of 89
            Pseudo Genes (frameshifted)       :: 7 of 89
            Pseudo Genes (incomplete)         :: 80 of 89
            Pseudo Genes (internal stop)      :: 8 of 89
            Pseudo Genes (multiple problems)  :: 6 of 89
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 09:06:26
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 631466
            Orig. end                         :: 652591
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            VYTZ01000004.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21125
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RRE-containing"
                     /region_number="2"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     cand_cluster    1..21125
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21125
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11125](-)"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11125)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     misc_feature    565..578
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.59"
                     /tool="antismash"
     gene            842..2485
                     /locus_tag="F5972_RS14155"
                     /old_locus_tag="F5972_14155"
     CDS             842..2485
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /NRPS_PKS="Domain: AMP-binding (38-448). E-value: 2.2e-72.
                     Score: 235.8. Matches aSDomain:
                     nrpspksdomains_F5972_RS14155_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012711.5"
                     /locus_tag="F5972_RS14155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F5972_14155"
                     /product="class I adenylate-forming enzyme family protein"
                     /protein_id="WP_225311462.1"
                     /sec_met_domain="AMP-binding (E-value: 1.1e-73, bitscore:
                     243.4, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHDPVAPPLPADTAEPAETETETEAEGGVFPQVLLDALRSAPGSP
                     AFEQGDRTVSRGELLDLIGRMAVAMREAGLGPGRGVAVRTGVTPEAFAAQIAAHVLGCR
                     VVAVKPGYTPRQLAHVLGPGVGAGADAGGETGVDAVVVDPASATPDVLGAAGPATVLSL
                     GPVAGVPAAVDILAAPGGGGSPIPAVTARPDDVALLTFTSGSTGEPKGCVLSYRGLGAH
                     WSWPRVWSSVEPGFADRFGRHMLFGTLASQVVLDFLAPCLLGGGTAVIPEDDGRPLFPY
                     AVERHRITSAIVTPPRLCQMLDLLREERADVGSLRMLMVAGSPVSPHRMREAADRLGPV
                     VYQGYGATEAGMIAILNPGDLGRAPDSVGRAHPSVEISVRDEEGRPVETGRTGEVHVRS
                     PFLMTGYRGQPEETRDVLRDGWLRTRDLGRLDDAGLLYLAGRTRDVVIVNAIVVYAGPI
                     ERVLAGHPDVAEAYVTGAPDERTGEAVHAFVVPVPGRAPDPAVLTALVRAELGADSVPR
                     TITMVPGVPVAASGKPDKRALLERHPPVAL"
     aSDomain        956..2185
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_F5972_RS14155_AMP-binding.1"
                     /evalue="2.20E-72"
                     /label="F5972_RS14155_AMP-binding.1"
                     /locus_tag="F5972_RS14155"
                     /protein_end="448"
                     /protein_start="38"
                     /score="235.8"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="RSAPGSPAFEQGDRTVSRGELLDLIGRMAVAMREAGLGPGRGVAV
                     RTGVTPEAFAAQIAAHVLGCRVVAVKPGYTPRQLAHVLGPGVGAGADAGGETGVDAVVV
                     DPASATPDVLGAAGPATVLSLGPVAGVPAAVDILAAPGGGGSPIPAVTARPDDVALLTF
                     TSGSTGEPKGCVLSYRGLGAHWSWPRVWSSVEPGFADRFGRHMLFGTLASQVVLDFLAP
                     CLLGGGTAVIPEDDGRPLFPYAVERHRITSAIVTPPRLCQMLDLLREERADVGSLRMLM
                     VAGSPVSPHRMREAADRLGPVVYQGYGATEAGMIAILNPGDLGRAPDSVGRAHPSVEIS
                     VRDEEGRPVETGRTGEVHVRSPFLMTGYRGQPEETRDVLRDGWLRTRDLGRLDDAGLLY
                     LAGRTRDVVIV"
     CDS_motif       1430..1486
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_F5972_RS14155_0001"
                     /evalue="6.10E-07"
                     /label="NRPS-A_a3"
                     /locus_tag="F5972_RS14155"
                     /protein_end="215"
                     /protein_start="196"
                     /score="21.9"
                     /tool="antismash"
                     /translation="ALLTFTSGSTGEPKGCVLS"
     CDS_motif       2009..2086
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_F5972_RS14155_0002"
                     /evalue="2.50E-05"
                     /label="NRPS-A_a6"
                     /locus_tag="F5972_RS14155"
                     /protein_end="415"
                     /protein_start="389"
                     /score="16.7"
                     /tool="antismash"
                     /translation="GRTGEVHVRSPFLMTGYRGQPEETRD"
     misc_feature    2487..2501
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.1"
                     /tool="antismash"
     gene            2550..4118
                     /locus_tag="F5972_RS14160"
                     /old_locus_tag="F5972_14160"
     CDS             2550..4118
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="other (smcogs) SMCOG1092: hypothetical
                     protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009072637.1"
                     /locus_tag="F5972_RS14160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F5972_14160"
                     /product="NAD(P)-binding domain-containing protein"
                     /protein_id="WP_150933891.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1.2e-16, bitscore:
                     56.1, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPEETLDYLVIGAGPAGLQMGHFLHRAGRSYRILEATPAPGAFFR
                     TFPRHRKLISINKKYTGWDDPELNLRMDWNSLLSDDPRLLFTQYSDRYFPDADDMVRYL
                     EDFAATLESHITYDARVAEVARPEPGGPFTVTDERGRTYQARRVIVATGVTLPNVPPIP
                     GVETAEQYGDVSVDPADYTNKRVLIIGKANSAFETADNLIETAAVIHVAGPHSVKLAWR
                     THFVGHLRAYNNNFLDTYQLKLQNAVLDGDVRRIERRADGSYLVTVAFVRADEVTKDIP
                     YDRVIVCTGFRFDPSIFAPECRPELAINDRFPALTPAFESVNVPDLHFAGTITQSRDFK
                     RGTSGFIHGFRYGVRALHRALEARYHGVEWPGRDLPAEPGALAAAVLERVNRSSALWQQ
                     FGVLADVIVPDGRGGARYLEEVPLDLQGPPVGDQGHFAVTLEYGPGHDQVDPFDISVGR
                     ITQSDAERAHEGHYLHPVVRRFRNGVVEAVHHVTENLENDWTSEQVHLNPLRDFFQHHS
                     IPVSV"
     misc_feature    2566..2581
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.72"
                     /tool="antismash"
     gene            4115..5161
                     /locus_tag="F5972_RS14165"
                     /old_locus_tag="F5972_14165"
     CDS             4115..5161
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013253.5"
                     /locus_tag="F5972_RS14165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F5972_14165"
                     /product="alpha-hydroxy acid oxidase"
                     /protein_id="WP_225311463.1"
                     /transl_table=11
                     /translation="MTTVLTTIGEYEAAARDRLAPAHYDYFAGGAGEEITLRANETAFA
                     RLALLPRVLRGAGSPRTGVTLLGSSLAMPVLVAPTAFHRLADPEGERATARAAATAGTV
                     MIVSMASTMAVEDVASAASGVTLWFQLYLQPDMDFTEAIVRRAEAAGCAALVVTVDSPA
                     RGRRDRDARNGFDDLPDGMCCENLRDGDRVRSIVMSPEIGWEHVDLLRRMTRLPIVLKG
                     VTHPADACLALDHGVSALYVSNHGGRQLDTVPAAVDLLPAIAAAVGGAVPVLVDGGIRR
                     GTDVVKALALGASAVAVGRPVIWGLAADGERGAARVLGLLRDEIEHALALCGVASVRDL
                     GPDLVRPC"
     gene            5155..6519
                     /locus_tag="F5972_RS14170"
                     /old_locus_tag="F5972_14170"
     CDS             5155..6519
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012296.5"
                     /locus_tag="F5972_RS14170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F5972_14170"
                     /product="cytochrome P450"
                     /protein_id="WP_191910104.1"
                     /sec_met_domain="p450 (E-value: 3.8e-21, bitscore: 70.6,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLTALWAAAAALVVISLPRWLPGRVVAVRGWVFTRINGDESIPVP
                     GDLVGVDRFREVYSHPAASGRSRGAALSDLFWYWLSPGPEMHQEHLEEGERYDAVALAT
                     RRILSVPRARAEELTRRCVTRTLRDGQGRERRGVVRLRDLMMPAWAEFSYELVFGEECP
                     PYARDLIVGNADDVVTALKCCGLRHMDRRDRLTAYLVESLPRVRQELPPGLTDREQALY
                     LQGAFFNTAVVQMSEATAHVLMALAQHPEVQDRARGGDDRYLDQVISETLRVYPLFGIA
                     HRVTTGDIPLGEGSAIPAGSVLCFDYPSFHRAGFPDPERFDPERFAPGHAPVRELNHIP
                     FGMPANRPCPAWRLAPLMMRVAVRETLRAYRLDSTAAHTRSLPNRGPCLLTPLGAPRGP
                     GHRLTLLFMRFRDDWENLWRSLVQLVLGTYMVWDARRLRLCERHFADLPGDAIRS"
     gene            6539..7870
                     /locus_tag="F5972_RS14175"
                     /old_locus_tag="F5972_14175"
     CDS             6539..7870
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0015297 - antiporter activity [Evidence
                     IEA]"
                     /GO_process="GO:0006812 - monoatomic cation transport
                     [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /GO_process="GO:1902600 - proton transmembrane transport
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1117:
                     sodium/hydrogen exchanger"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF013188.5"
                     /locus_tag="F5972_RS14175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F5972_14175"
                     /product="cation:proton antiporter"
                     /protein_id="WP_191910105.1"
                     /transl_table=11
                     /translation="MFVPALSLAAAPATDHNLQLVLKVLPALAVILLAAAVCGRLATMV
                     MQPRVVGEMVAGVLLGPTLLGALFPDAQAALFPADVRPVLYVLSTIGLTLYMFLVGAGI
                     DHDARAPGELRKASVLAASGIGSPMILGVGAGLLMWGQLSRPDVGRLEFALFLGGALSL
                     TAFPMLARILYERGLQNTRVGRLTLLAASIDDAVAWCLLAALSAVHLGGGPADTLRTIA
                     LTAGFAAVMLLVVARLLRPLGRQVARTGQFGAGAVYVVVLVPLTAGFITDAIGVYSVFG
                     GFIAGLAMPREPAFRAALHSRMMDVVSTLLLPVFFAFSGLNTHLAGIAGGPALLAFAVI
                     LAAAFCGKYFGCSLATRAMGFGWRESWAVGAMMNARGLMILIFINIGLAQGMITQEVFA
                     MLVLVAVITTAGAMPLYKLALPERLERVRAAEAESVAGRERAAA"
     misc_feature    complement(7969..7983)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.51"
                     /tool="antismash"
     misc_feature    7980..7994
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.3"
                     /tool="antismash"
     gene            8062..8700
                     /locus_tag="F5972_RS14180"
                     /old_locus_tag="F5972_14180"
     CDS             8062..8700
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012301.5"
                     /locus_tag="F5972_RS14180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F5972_14180"
                     /product="response regulator transcription factor"
                     /protein_id="WP_225311464.1"
                     /transl_table=11
                     /translation="MEDDRELGDMLADVLTDQGYTVDLALEGQRGLHLGLSRGYDVMII
                     DRGLPVVDGLDLLRRLRRQAVTVPVLMLTGFGAVADRVTGLDAGAEDYLVKPFEIDELL
                     ARIRALHRRNLDQAALLPLGAGWLDSASFTVRLPSGEQVTLSGREYWLLHALAARPRQV
                     HTRSSLRQRVFDGASTESIVDTYVYYLRNKLGPGVVRTVRGVGYRLGEL"
     misc_feature    complement(8093..8107)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.07"
                     /tool="antismash"
     gene            8697..9998
                     /locus_tag="F5972_RS14185"
                     /old_locus_tag="F5972_14185"
     CDS             8697..9998
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF014567.5"
                     /locus_tag="F5972_RS14185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F5972_14185"
                     /product="cell wall metabolism sensor histidine kinase
                     WalK"
                     /protein_id="WP_225311465.1"
                     /transl_table=11
                     /translation="MTPRRPFDPERRLLIRARRRITLQVAGVFCLVTAVMGAVVFWAVA
                     HGQDVGARRDLAVAAQVAPISQPPPCVWLFELHGGTMRSSPGAPSILPIRATLDAVAAD
                     GRTRTGLVHLAGRDLLVHTQLRGDVPVQAVQDLRYQTAERQRLLRVLGAAEIAALLAAL
                     LIGQVLARRAIAPLGEALDRQRRFTADVSHELRSPLARLHVRAQLAARRLGREPDPVVV
                     AGDLDRLVTGIGQLGEVIEDLLLSSQLRQHRPSGPVDLAALAEESAGAEAARAGQRGVT
                     IDVRWGPGDHLVRGAQSALRRVISALLDNALRHTSAGGHIWVTICSGPDVVQLSVRDDG
                     VGLDPREGERLFARHAGAPHSGGLGIGLALVSEVVDAHGGTVHVDGRPGAGAVFTISLP
                     RTAAEPVPSEPRLLLPQQARSGPSLPARDGPAGR"
     gene            complement(10001..11125)
                     /locus_tag="F5972_RS14190"
                     /old_locus_tag="F5972_14190"
     CDS             complement(10001..11125)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Pantocin_Microcin_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ThiF"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF013094.5"
                     /locus_tag="F5972_RS14190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F5972_14190"
                     /product="ThiF family adenylyltransferase"
                     /protein_id="WP_225311466.1"
                     /sec_met_domain="Pantocin_Microcin_RRE (E-value: 8e-13,
                     bitscore: 43.7, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="ThiF (E-value: 1.2e-44, bitscore: 147.8,
                     seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKAQHRPHRYGTDRIRIGAPTYGATAEISDPGGHAWAALNAMDGT
                     RTPEEIATRLVRAFPGLSETEAAGVVRLLLDSGYVEDAAGPRPEEFGLPELERYSRNAA
                     YFRGADLVPRDIPRDGPRDHGWEAQVRLKRSRVLVLGLGGTGSHTAWALAACGVGEIHC
                     VDRDVVELSDLTRQALYREADVGSPKVDVAAARLAEVNSSVRVTGETRAAECEEDMLDL
                     VRGFDAVAMCADEPAGRGGIRVWANRACLAERIPWALGGYNGPLVSVAAFVPGGPCYEC
                     LTASVDASLAPGIPVGLGGPGVIAPSAGVSGHLTAQAVIAFLTGIPAVLGSHVTGINLV
                     SPDQHVYSRPPAAPDCPACAPHTLPAEPLRSVAG"
     aSDomain        complement(10871..11122)
                     /aSDomain="Pantocin_Microcin_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing E1-like protein in a
                     pantocin/microcin cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_F5972_RS14190_Pantocin_Microcin_RRE.1
                     "
                     /evalue="3.50E-14"
                     /identifier="RREFam017.1"
                     /label="F5972_RS14190"
                     /locus_tag="F5972_RS14190"
                     /protein_end="85"
                     /protein_start="1"
                     /score="43.7"
                     /tool="antismash"
                     /translation="KAQHRPHRYGTDRIRIGAPTYGATAEISDPGGHAWAALNAMDGTR
                     TPEEIATRLVRAFPGLSETEAAGVVRLLLDSGYVEDAAG"
     misc_feature    11185..11199
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.16"
                     /tool="antismash"
     gene            complement(11268..12614)
                     /locus_tag="F5972_RS14195"
                     /old_locus_tag="F5972_14195"
     CDS             complement(11268..12614)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="F5972_RS14195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="F5972_14195"
                     /product="cytochrome P450"
                     /protein_id="WP_150933894.1"
                     /transl_table=11
                     /translation="MPLESLLTREYQADPARVHERLRAAYGPVAPIELHGVPVWFAFGY
                     DEVRYIMQNPDDFWSKHVGHWRAFAEGRIPADWPLIPLLSADNSGFHDGDRHRGLRGAW
                     IAGLREFQEPGGEHTQKLERAILKYCDDLIGVMTEGTPTGWADLAAQYGRPLPLMVANH
                     LLGVTLDRGEEMIMDQWRLLDGPDAAGAYQRLNTALLELATTKRHRPGHDLPSAMFAAA
                     PALTPEEVARELFMLSGFLDFTGSLICNVIVEAVGNPDLRTSVTSGQIEELVNRVALLN
                     PALANLTFRYARTAVKLGRFTIAAGDPVMLSISGAHADPLFASALNRDTVRSTRAHLAW
                     GAGPHRCPSQRLATQMCTIAVRRLLDRISALTLATPPEQLPWRPSPFVRALRSLPVRFE
                     VNPNAVPVSRPGPATAGQEPPPEETDADGWRPPARSGFWTFLRKLRRAP"
     gene            complement(12905..15361)
                     /locus_tag="F5972_RS14200"
                     /old_locus_tag="F5972_14200"
     CDS             complement(12905..15361)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020541804.1"
                     /locus_tag="F5972_RS14200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F5972_14200"
                     /product="ExeM/NucH family extracellular endonuclease"
                     /protein_id="WP_150933895.1"
                     /transl_table=11
                     /translation="MRATPRALAILVTAGLAAGSIAALSPAPAAAAPGTVVISQVYGGG
                     GNSGAPLTNDYVELFNRTGASVSLSGWSVQYTSATGTGNFSANKTDLSGTLAPGQYHLV
                     QLAAGTTPSGSLPTPDDVGGVNMSGTAGKLALVRSTTGLACNGSTVPCTDEQLALVADL
                     VGYGTANFFEGTPAPGLTNGTAAIRRGGGCTDTDDNGADFEAAAPAPRNSASTAAPCAG
                     PDPSPSPSATPSESPSPSASPSASPSESPSPSPSASPSPSASPSPSATPSPSPTCDTPV
                     THRIAQVQGDGDVSPVAGQDVRVEGVVTGSFQGAGQLGGFYVQDPKPDKDPATSEGVFV
                     FSSSPVKAGDRVLVSGKAVEYNGLTEISPATAVNVCGTGTIKPVEVNLPLKEGATFERY
                     ENMLVTFKDDMAASEIYNLGRYGEITLAEGGRLWQPTDRKGVDTGKDARRSILLDDGSN
                     AQNPPTLPYHTEGSNTVRIGDEVKNLTGVLTYGFGVYRVEPTQPVVFRPENPRPAEPKR
                     VGGNVRVASLNTLNWFTTLKSRGATTAAERDRQLAKLVANILALDPDVAGLMEIERNNN
                     VALNALVDALNAAAGAGTYKAITHPNPGTDLIQTALIYKPAKVTPIGGPQSSADPIFSR
                     PPLVQTFGRANGKGEIFTILVNHFKSKGCTDGPDSIPATGADADQGDGQSCFNAKRVKQ
                     AQAVLALIDSLKLRNTLVVGDINAYGEEDPIHTFEDAGLVSLSKKHVKKEDRYSYLFEG
                     LSGELDHALADKKLNRLVTGATIWHVNADEGRFMDYNTEFNPPYLYAPDAYRSSDHDPL
                     LIGLGL"
     misc_feature    15540..15557
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 16.19"
                     /tool="antismash"
     misc_feature    complement(15548..15561)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.51"
                     /tool="antismash"
     gene            15736..19686
                     /locus_tag="F5972_RS14205"
                     /old_locus_tag="F5972_14205"
     CDS             15736..19686
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012376.5"
                     /locus_tag="F5972_RS14205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F5972_14205"
                     /product="metallophosphoesterase"
                     /protein_id="WP_191910106.1"
                     /transl_table=11
                     /translation="MRRRGRLAAAVVIAMVATLLAGAVVTAAHADPGPAKAGQGRPSPA
                     PTGSPTPPTLSPAGGSYLEGMVKVAAVPAAAGDSVTKLAVDGGALNATRTVGVSRLRFD
                     VGSNSTEARYHNYVLVNGAYRTDIGDLVNERATIEIPNEHLVKGENTIEIFAGTVQSSC
                     GTNYDDFVLSDVGLELLGEVADGEDNPYTLSFGDGNCGSNTALLKQAALKFFVKGDPQG
                     TTGLAADLDTTTLANGEHAITATTASGATVKNAVTVNNAPAGAPRLTPTDGTLVAGTTP
                     VSATVPAVGAGGVSALTVDGAEPAGKATLGDGAAKFSFDVGADAIEDKYDDFLLVNGKR
                     VDLGGSWVNQRVTVAVPARLLVPGDNVIKVMTGDWKASCGVDRDDFTIANLGLALDGAT
                     VTGRDVKPSYDMGDGTCGSGQTTLREVELRYTIDAPGVRVVRTLGSGDATLSFTVGSNS
                     IEARYQNHLLVNGRKVVLDGDFVSRRVDFTFPNEYLVPGWNTIDFVTGTYPTSCGNNRD
                     DFAISNIALTPVRGTASGQMLKGSYSMGDGNCGDNVNLLTEIDLEFLVDAPAAGLRADL
                     DTTAIKDGRHTLAATSTTGEKATRTLVTDNTAPKVAASVPAAGEKITASVVLDVTLEDA
                     SGVVSGPDVTLDGQAIALGAQVGPGLSPGRHTLAVTGADSLGNTATREIAFESAGIPDV
                     PAELTPASGTADVPGTVTLSAKVAEPGGGKVKATFSEADILTPNQAYQGVVDAVPTTLQ
                     VPGEKKLKATGLEPADGATLDAPAGRDVTYQRYDIQVKGHVDAPVLRWEGVIDPERLVS
                     LRAWNTKARAWDLLTSARGSAEGQTALTAVVGDRYVDGQQVHVMVTGEDPFADDIDPGD
                     PNGFADPSTYDFSIVHFTDTQYLSEGAVEQETAEERAVWESAYAGIVNWIKGNRDQRKI
                     SYVAHTGDIIENNIRKPADEATQREVTGELEVSSKQQKVLDDAGIPNGVIAGNHDNQSG
                     TEDGPEAIYNKYYGPGRYQTAAQGWQHAEYGGPWKEGDNQNHYDLFSAGGLDFVVVGLS
                     YGVTREEAEWADSVFKRFPGRNGILLSHDYLVPSTNPDGRGAGFSAPDGSMLYKTVVEK
                     NPNVFLILAGHEHGVGTNVKPKVGQVGNGVVELLADYQFYTVSADRLGLTQVGGYNPDD
                     QLQFGASFFRLLQFNVKRAELTVDTYSPLLNDFGAGEFDPLRRYDGREDNMVLPVDLTT
                     RTTSFATDSLAIYKPTRVIGTSTVESGQVASVTWNRLKGDTAYAWFVTARSTGGGVTAS
                     EPSVFVTRDEHGRPGKWGPDSPLYRWFQHKKG"
     misc_feature    19765..19783
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 19.32"
                     /tool="antismash"
     gene            19781..20917
                     /locus_tag="F5972_RS14210"
                     /old_locus_tag="F5972_14210"
     CDS             19781..20917
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025167.5"
                     /locus_tag="F5972_RS14210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="F5972_14210"
                     /product="HupE/UreJ family protein"
                     /protein_id="WP_150933897.1"
                     /transl_table=11
                     /translation="MSRRRRLSAAVLALACAVACALGVLAAAPASAHDATTKAHATVTG
                     TGADVRVVLDLEYDLLMKSAWLYAEAYDAKERAEQLRQLKKNHAAVVDYITRRFAVAYG
                     DSPCTPTPVGDADVRTRDGVAFAVVTLAYRCAGDGDGGHTVSSAIFPDAESFVHSTQTI
                     VGYTLDGTTGSAVLTAANPTLRVGEHRASHQVGEFFLLGAEHLLSGLDHVFFLLALLIG
                     ARRARDVVVTASAFTAAHSITFLLAALGIVHVPAGIVEPVIAVSIIVVAVANLLGRDED
                     RLGGWRLPIVFAFGLVHGLGFASALDIEEKGSWELLLSLLSFNAGIEATQLLIIAVLFP
                     LLALLRRTSAAHWMTAAMSVPIVAVSLYWCVDRIALPL"
ORIGIN
        1 aggccgtgga tctcgaaccc tgcccgggcc gtccagtcct cgcgggccag ccgcacccgt
       61 tgctgctgag ccgccccgtc ccggcgccgg tgcacttcaa tgccgtcgtc gcggtagccg
      121 agcttgcgcg acacggcgag cgatcggggg ttgtcgacga aggccgacga cgtcgcgtgg
      181 cgcgccccga gcccggcgaa cgcgaggtgc aggacggcgg cgcgcatctc ggtgccgatg
      241 cccttgtcct ggaagcgcag gcccagccag gaaccggtgg agatctcccg ggtgtacgcg
      301 aagtcgcggc ccgccatctc ctgcgtgccg acgatccggc cctcccaggc gacgacgaag
      361 ctgcaactcc agtcgtcggg cgaccaggcg ccccactgcc ggaagtgaat ctggacggtc
      421 gagcgggcgc gctcgtccgg cggggcgtcc gtccacggca cgccgaacgg catccccccg
      481 ggctcgtgga cgccttccgc cgcgcggtcg gcgagcgcgt cgaggtcgtc cagggtcggc
      541 agccggagtt ccagccgggg agtcgtcacc ctgagcgcga agagcggcca gtgtcgcatg
      601 cgccgatcct gacaagaccg tgcgcctcgc cgcaccccga tttccacgaa cggccttcca
      661 cgggcctcgg agtgatcgcg accgccgcgg acccggaacg aggcgctctg attcggctct
      721 gatgcggctc tgatgtgcgc ctcctaccgt cggcgggcgt gaggccggtg gcacaccggc
      781 acccgcgccg cggccgacgg cgtcgccgcg gcagggcgcc cgcgagacga aggagccgga
      841 cgtgcacgat cccgtcgcac cccccttgcc cgccgacacc gccgagcccg ccgagaccga
      901 gaccgagacc gaggcagagg gcggggtgtt tccgcaggtc ctcctggacg cgctgcggag
      961 cgcgcccggc agcccggcct tcgaacaggg ggacaggacc gtctcccggg gtgagctgct
     1021 ggacctcatc gggcgcatgg ccgtggcgat gcgggaggcg ggcctcggcc ccggccgggg
     1081 cgtcgccgta cggaccgggg tgacgccgga ggcgttcgcc gcccagatcg ccgcgcacgt
     1141 gctgggctgc cgcgtcgtgg cggtgaagcc cggatacacg ccccgccagc tcgcgcacgt
     1201 cctcgggccg ggagtcgggg cgggagccga cgcgggaggc gaaacgggag tcgacgcggt
     1261 ggtcgtcgac ccggcgtccg cgaccccgga cgtgctgggc gcggccgggc cggccacggt
     1321 gctgtcgctc ggtcccgtcg ccggtgtgcc cgccgccgtc gacatcctcg ccgcaccagg
     1381 aggaggcggc agcccgatcc ccgccgtcac ggcgcgtccg gacgacgtgg ccctgctgac
     1441 cttcaccagc ggcagcaccg gcgagccgaa gggctgcgtg ctcagctatc gcggcctcgg
     1501 cgcgcactgg tcctggccac gcgtctggtc gtcggtcgag cccggcttcg ccgacaggtt
     1561 cgggcggcac atgctgttcg gcaccctggc cagccaggtg gtgctggact tcctcgcgcc
     1621 gtgcctgctc ggcgggggca ccgcggtcat cccggaggac gacggccggc cgctgttccc
     1681 gtacgcggtc gagcgtcacc gcatcaccag cgccatcgtg accccgcccc ggctgtgcca
     1741 gatgctcgac ctgctccgcg aggagcgggc cgacgtcggc agcctgcgca tgctgatggt
     1801 cgccggatcg cccgtcagcc cgcaccggat gcgggaggcg gcggaccggc tcggccccgt
     1861 cgtctaccag gggtacggcg cgaccgaggc cgggatgatc gcgatcctca accccggcga
     1921 cctcggccgc gcgccggact ccgtcggccg tgcccacccc agcgtcgaga tcagcgtgcg
     1981 cgacgaggag ggccgcccgg tcgagacggg acgcaccggt gaggtccacg tgcgcagccc
     2041 cttcctgatg acgggctacc ggggacagcc ggaggagacc cgcgacgtgc tgcgggacgg
     2101 ctggctgcgc acccgcgacc tcggccgcct cgacgacgcg ggcctgctct atctggccgg
     2161 ccggaccagg gacgtcgtca tcgtcaacgc gatcgtcgtc tacgcggggc ccatcgagcg
     2221 ggtgctggcc gggcacccgg acgtggccga ggcgtacgtg accggcgcgc cggacgagcg
     2281 gaccggggag gccgtccacg ccttcgtcgt ccccgtgccc ggccgcgcgc cggaccccgc
     2341 cgtcctcacc gccctggtcc gcgccgaact cggcgcggac agcgtgcccc ggacgatcac
     2401 gatggtgccc ggcgtaccgg tcgcggcgag cggcaaaccg gacaagcgcg ccctgctgga
     2461 gcggcacccg ccggtagcgc tctgagagat ttctgagaat cccccgccaa cactggtgaa
     2521 acttcaacca cccagcgagg gaggcggcag tgccggaaga gacccttgac tacctggtga
     2581 tcggcgccgg accggcgggc ctgcagatgg gccatttcct gcaccgggcg gggcggagct
     2641 accggatcct ggaggcgacg cccgcgccgg gcgcgttctt ccggaccttc ccccgccacc
     2701 ggaagctgat ctccatcaac aagaagtaca ccggctggga cgacccggag ctcaacctcc
     2761 ggatggactg gaactcgctg ctgtccgacg acccccggct cctgttcacc caatacagcg
     2821 accgctactt ccccgacgcc gacgacatgg ttcgctacct ggaggacttc gccgccaccc
     2881 tggagtcgca catcacgtac gacgcgcggg tcgccgaggt cgcgcgcccg gagcccggcg
     2941 gcccgttcac ggtgaccgac gagcgcggcc ggacgtacca ggcccggcgg gtgatcgtcg
     3001 cgacgggggt caccctgccc aacgtcccgc cgatccccgg cgtcgagacc gccgaacagt
     3061 acggcgacgt ctccgtcgat cccgccgact acacgaacaa gcgggtgctg atcatcggca
     3121 aggccaactc ggccttcgag accgccgaca acctcatcga gacggccgcg gtcatccacg
     3181 tggccgggcc gcactcggtc aagctggcct ggcggacgca cttcgtcggg cacctgcgcg
     3241 cgtacaacaa caacttcctc gacacctacc agctcaagct gcagaacgcc gtgctggacg
     3301 gcgacgtccg gcgcatcgag cgccgggccg acggctccta cctggtgacc gtggcgttcg
     3361 tccgggccga cgaggtcacc aaggacatcc cgtacgaccg ggtgatcgtc tgcaccggat
     3421 tccggttcga cccctcgatc ttcgctcccg aatgccggcc ggagctggcg atcaacgaca
     3481 ggttcccggc gctgaccccg gcgttcgagt cggtcaacgt gccggatctc cacttcgccg
     3541 ggacgatcac ccagtcgcgc gacttcaagc gggggaccag cgggttcatc cacgggttcc
     3601 ggtacggcgt gcgcgccctg caccgggccc tggaggcgcg gtaccacggc gtggagtggc
     3661 cgggtcgcga cctgcccgcc gagcccggcg cgctcgcggc ggccgtgctc gaacgggtca
     3721 accgcagttc ggcgctgtgg cagcagttcg gggtgctggc cgacgtcatc gtgcccgacg
     3781 gccgcggcgg cgcgcgctac ctggaggagg tgccgctcga cctgcagggg ccaccggtcg
     3841 gcgaccaggg tcacttcgcc gtcacgctgg agtacggccc cggccacgac caggtggacc
     3901 ccttcgacat ctcggtgggg cggatcaccc agagcgacgc ggagcgcgcg cacgagggcc
     3961 actacctcca ccccgtggtg cgccgcttcc ggaacggcgt ggtggaggcg gtccaccacg
     4021 tcaccgagaa cctggagaac gactggacgt ccgagcaggt gcatctcaac ccgctgcggg
     4081 acttcttcca gcaccacagc atcccggtct cggtgtgacg accgtgctca cgaccatcgg
     4141 ggagtacgag gcggcggccc gcgaccgcct cgcccccgcc cactacgact acttcgccgg
     4201 cggggccggc gaggagatca ccctgcgggc caacgagacg gcgttcgccc ggctcgcgct
     4261 gctgccgcgc gtgctgcgcg gcgcggggag cccccggacc ggggtcaccc tgctcggcag
     4321 ctccctggcc atgcccgtgc tggtggcgcc gaccgcgttc caccggctgg ccgatcccga
     4381 gggcgagcgg gccacggccc gtgcggcggc caccgcgggc accgtcatga tcgtgagcat
     4441 ggcctcgacc atggccgtcg aggacgtcgc gtccgccgcg tcgggcgtca ccctgtggtt
     4501 ccagctctac ctccagccgg acatggactt caccgaggcg atcgtccggc gggcggaggc
     4561 ggccggctgc gcggcgctgg tcgtcacggt cgactcccca gcccgggggc ggcgggaccg
     4621 ggacgcccgc aacggcttcg acgacctgcc cgacggcatg tgctgcgaga acctgcgcga
     4681 cggcgaccgg gtgcggtcca tcgtcatgtc gccggagatc ggctgggagc acgtcgacct
     4741 gctgcggcgg atgacccggc tgccgatcgt gctcaagggc gtcacccacc ccgccgacgc
     4801 ctgcctcgcc ctcgaccacg gcgtgtcggc gctgtacgtg tcgaaccacg gcggacggca
     4861 gctcgacacc gtcccggccg ccgtcgacct gctgccggcg atcgccgccg ccgtcggcgg
     4921 cgccgtaccc gtgctggtgg acggggggat ccggcgcggc accgacgtgg tgaaggcgct
     4981 ggcactcggc gcgtccgccg tcgcggtggg ccgtccggtg atctggggcc tcgcggcgga
     5041 cggcgagcgc ggcgcggcgc gcgtgctcgg gctgctccgc gacgagatcg agcacgcgct
     5101 cgccctgtgc ggcgtcgcct ccgtacggga cctcggaccc gacctggtgc ggccgtgctg
     5161 accgcgctgt gggcggcggc cgcggccctc gtcgtgatca gcctgccccg gtggctcccc
     5221 gggcgggtcg tcgcggtgcg cgggtgggtc ttcacccgga tcaacggcga cgagagcatc
     5281 ccggtcccgg gagacctcgt cggcgtcgat cggttcaggg aggtctactc ccacccggcg
     5341 gcctccggcc gcagcagggg cgccgccctg tcggacctgt tctggtactg gctgtcgccg
     5401 gggcccgaga tgcaccagga acatctggag gagggagagc gctacgacgc cgtcgccctg
     5461 gccacccgcc ggatcctgtc cgtgccgcgg gcgcgggcgg aggagctcac ccgccgctgc
     5521 gtcacccgta cgctgcggga tgggcagggg cgggagaggc gcggcgtggt ccggctgcgt
     5581 gacctgatga tgccggcgtg ggccgagttc tcctacgagc tcgtcttcgg cgaggagtgc
     5641 ccgccgtacg cccgcgacct gatcgtcggc aacgcggacg acgtcgtcac cgccctgaag
     5701 tgctgcggcc tgcggcacat ggaccggcgc gaccggctga ccgcgtatct cgtcgagtcg
     5761 ctgccacggg tgcggcagga actcccgccc ggcctgacgg accgggagca ggcgctgtat
     5821 ctccagggcg ccttcttcaa caccgccgtg gtgcagatgt cggaggccac ggcgcacgtg
     5881 ctgatggccc tcgcgcagca tccggaggtc caggacaggg cgcggggcgg cgacgaccgc
     5941 tacctcgacc aggtgatctc ggagacgctg cgggtctatc cgctcttcgg catcgcgcac
     6001 cgcgtcacca ccggcgacat ccccctcggg gaggggtccg cgatcccggc cggctcggtg
     6061 ctgtgcttcg actacccctc cttccaccgc gccggtttcc ccgatccgga gcgcttcgat
     6121 ccggagcgct tcgcccccgg ccacgccccg gtccgggagc tcaaccacat cccgttcggc
     6181 atgccggcga accgcccctg cccggcctgg cggctcgccc ccctgatgat gcgggtcgcg
     6241 gtgcgggaga ccctccgggc gtaccggctc gactccaccg ccgcccacac ccggtccctg
     6301 cccaaccggg gaccctgcct tctcaccccc ctgggggccc cgcgcgggcc cggacaccgc
     6361 ctgacgttgc tgttcatgcg gttccgggac gactgggaga acctctggcg cagtcttgtg
     6421 cagctcgtcc tcggcaccta catggtctgg gacgcgcgga ggctgcgact gtgcgagcgc
     6481 cacttcgccg atcttcccgg cgacgccatc cgatcatgag ctgctgagga gcatgtgcat
     6541 gttcgttccg gccctttccc tggcggccgc ccccgccacc gaccacaacc tccaactggt
     6601 cctcaaggtg ctgccggccc tggccgtcat cctgctggcc gcggcggtgt gcggccgcct
     6661 ggccaccatg gtcatgcagc cgcgcgtcgt cggcgagatg gtcgccggtg tcctgctcgg
     6721 gccgacgctg ctcggcgcgc tgttccccga cgcccaggcg gcgttgttcc ccgccgacgt
     6781 ccgacccgtc ctgtacgtgc tcagcaccat cggcctgacg ttgtacatgt tcctcgtcgg
     6841 agccgggatc gaccacgacg cccgcgcccc gggcgagctg cgcaaggcga gcgtgctggc
     6901 ggcgtcgggg atcggctccc cgatgatcct cggcgtcggc gccgggctcc tcatgtgggg
     6961 ccagctctcc cgccccgacg tcggccggct ggagttcgcc ctgttcctcg ggggagcgct
     7021 gtcgctcacc gcgttcccca tgctcgcgcg gatcctgtac gagcgcgggc tgcagaacac
     7081 gcgggtcggc cggctcaccc tgctggccgc ctccatcgac gacgccgtgg cgtggtgcct
     7141 gctcgcggcg ctgtcggcgg tgcatctggg cggcggcccg gccgacacgc tgcgcaccat
     7201 cgccctgacg gcggggttcg cggccgtgat gctcctggtg gtggcccggc tgctgcgtcc
     7261 gctgggccgc caggtcgccc gcaccgggca gttcggcgcg ggcgccgtct acgtggtcgt
     7321 cctggtgccg ctcaccgccg ggttcatcac cgacgcgatc ggcgtctact cggtgttcgg
     7381 cggcttcatc gccgggctcg ccatgccgcg cgagccggcg ttccgcgccg ccctgcacag
     7441 ccggatgatg gacgtcgtct cgaccctgct gctccccgtc ttcttcgcgt tctccgggct
     7501 gaacacccat ctcgcgggca tcgcaggagg tcccgcgctc ctggccttcg cggtgatcct
     7561 ggcggcggcc ttctgcggga agtacttcgg ctgctccctc gcgacgaggg cgatgggctt
     7621 cggctggcgc gagtcctggg cggtgggcgc gatgatgaac gcccgcgggc tgatgatcct
     7681 catcttcatc aacatcggcc tggcccaggg catgatcacg caggaggtct tcgcgatgct
     7741 cgtcctcgtg gccgtgatca ccaccgcggg cgccatgccg ctctacaaac tggcgcttcc
     7801 ggagcgcctg gagcgggtgc gcgcggcgga ggcggagagc gtggccgggc gcgagcgggc
     7861 ggccgcctga gaccggtttc agctactttc acgtttcggt cgcgaggcgg ccgggggaaa
     7921 cctgctgaaa ccgcagaacg caggcgacgg gagccggaag cgcgatccaa aagtctggat
     7981 atttcccgat attggtgcca cggtattgca gtggcacgga tatcggggac atccgaaccg
     8041 cgctctcgtc gcctgctgct cgtggaggac gaccgcgagc tgggagacat gctggccgat
     8101 gtgctcaccg accagggata cacggtcgac ctggcactgg aggggcagcg gggcctgcat
     8161 ttgggactga gccgcggcta cgacgtcatg atcatcgacc gcgggcttcc cgtggtcgac
     8221 gggctcgacc tgctgagacg cctgcgccgc caggcggtca ccgtgccggt gctgatgctc
     8281 accggcttcg gcgccgtcgc cgaccgggtc accgggctcg acgccggcgc cgaggactat
     8341 ctggtcaagc cgttcgagat cgacgaactg ctggccagga tccgcgccct gcaccgcagg
     8401 aacctggacc aggccgcgct gctgccgctc ggcgccggct ggctcgactc cgcgtccttc
     8461 accgtacggc tgccgtccgg agagcaggtg acgctgtcgg gccgggaata ctggctgctt
     8521 cacgcgctgg cggcccgccc ccggcaggtg cacacgcgct cctcgctgcg gcagcgggtc
     8581 ttcgacgggg ccagcaccga gtcgatcgtg gacacctacg tctactatct gcgcaacaag
     8641 ctgggcccgg gcgtcgtacg caccgtgcgc ggcgtcggat accgcctggg cgagctgtga
     8701 cgccccgacg gcccttcgat ccggagcgcc gcctgctgat ccgcgcccgc cgccggatca
     8761 ccctgcaggt cgcgggcgtc ttctgcctgg tgacggcggt gatgggcgcg gtcgtcttct
     8821 gggcggtggc gcacgggcag gacgtcggtg cccggcggga cctcgccgtc gcggcgcagg
     8881 tggccccgat ctcccagccc ccgccctgcg tctggctctt cgaactgcac ggcggcacca
     8941 tgcggagctc gcccggggcg ccgtcgatcc tgccgatccg cgcgacgctg gacgcggtcg
     9001 ccgccgacgg gaggacgcgg accggcctcg tccacctcgc cgggcgcgac ctgctggtcc
     9061 acacccagct tcgcggcgac gtgccggtgc aggcggtgca ggacctgcgc taccagaccg
     9121 ccgagcggca gcggctgctg cgggtcctcg gtgccgccga gatcgcggct ctcctggcgg
     9181 cgctgctgat cggccaggtc ctcgcccgcc gggcgatcgc gccgctgggc gaggcactcg
     9241 accggcagcg ccggttcacc gccgacgtca gtcacgagct gcgcagcccg ctggcccgcc
     9301 tgcacgtccg cgcccagctc gccgcccggc gcctgggccg ggaaccggat cccgtcgtcg
     9361 tcgccggcga cctcgaccgg ctggtcacgg gcatcgggca gctcggcgag gtgatcgagg
     9421 acctgctgct gtcgagccag ctcaggcagc accggccgtc cgggccggtc gacctggccg
     9481 ccctcgccga ggagtcggcc ggagccgagg cggcccgcgc cggccagcgc ggggtgacga
     9541 tcgacgtgcg gtgggggccg ggcgaccacc tcgtgcgggg agcgcagtcc gcgctccgcc
     9601 gggtgatctc cgcgctcctc gacaacgcgc tccggcacac ctccgcgggc ggccacatct
     9661 gggtgacgat ctgttcgggg cccgacgtgg tccagctcag cgtgcgggac gacggggtgg
     9721 ggctggaccc gcgcgagggc gagcggttgt tcgcccggca cgccggggcg ccccacagcg
     9781 gaggtctcgg catcggcctg gctctcgtga gcgaggtggt ggacgcccac ggcggcacgg
     9841 tgcacgtcga cgggcggccg ggggccgggg ccgtcttcac catcagcctg ccccgtacgg
     9901 cggcggaacc ggtgccgagc gagccccggc tcctgctgcc gcaacaggcg cggagcgggc
     9961 cctccctgcc cgcccgggac gggccggcgg gccggtgacc tcagcccgcg acgctgcgga
    10021 ggggttcggc gggcagcgtg tgcggggcgc aggccgggca gtccggcgcc gccggagggc
    10081 gggagtagac gtgctggtcg ggggagacga ggttgatccc ggtgacgtgg ctgcccagga
    10141 ccgcggggat cccggtcagg aacgcgatga cggcctgggc ggtcaggtgc cccgacaccc
    10201 cggccgaggg tgcgatcacg cccggcccgc cgaggccgac cgggattccg ggggccagtg
    10261 aggcgtcgac gctcgcggtc aggcactcgt agcaggggcc gccggggacg aacgcggcca
    10321 cgctgaccag cgggccgttg tagccgccga gcgcccaggg gatccgctcc gccaggcagg
    10381 cgcggttggc ccagacgcgg atgccgcccc ggccggcggg ctcgtcggcg cacatcgcca
    10441 cggcgtcgaa gccgcggacg aggtcgagca tgtcctcctc gcactcggcc gcgcgggtct
    10501 ccccggtcac ccgtacggag gagttgacct cggcgagccg ggcggcggcc acgtccacct
    10561 tggggctgcc gacgtcggcc tcgcggtaga gggcctgccg ggtgaggtcg gacagttcga
    10621 ccacgtcgcg gtcgacgcag tggatctcgc cgacgccgca cgcggcgagc gcccaggcgg
    10681 tgtggctgcc cgtcccgccc agcccgagga cgaggacacg cgagcgcttg aggcgcacct
    10741 gcgcctccca gccgtgatca cgggggccgt cgcgggggat gtcgcggggc acgaggtcgg
    10801 cgccgcggaa gtacgccgcg ttgcgtgagt accgttcgag ctcgggcagg ccgaactcct
    10861 cgggccgcgg gcccgcggcg tcctcgacgt accccgagtc gagcaggaga cggacgacgc
    10921 cggccgcctc ggtctcggac agtccgggga aggcgcggac cagacgggtg gcgatctcct
    10981 cgggggtccg cgtgccgtcc atcgcgttca gcgccgccca ggcgtggccg ccgggatcgc
    11041 tgatctccgc cgtcgcgccg taggtcggtg cgcctatccg gatccggtcc gtcccgtatc
    11101 tgtgcggacg gtgctgggct ttcacacggg gcaaccgcac ggcgacctct cggcatcgcg
    11161 agcatgacca tcatcgacag gtggatcttt ctggaagtgt ccaggtctgt caaggacgat
    11221 gcccaagtcg catcggcggg cttacggggc cggctcactg ggccggctca gggggcgcgg
    11281 cgcagcttcc gcaggaacgt ccagaagccg gaccgggcgg gcggccgcca gccgtcggcg
    11341 tccgtctcct ccggcggcgg ctcctggccg gcggtcgccg gacccgggcg ggacacgggc
    11401 acggcgttgg ggttgacctc gaaccgcacg ggcagggagc gcagcgcgcg gacgaacggg
    11461 gagggccgcc agggcaactg ctcgggcggg gtcgccaggg tgagcgccga gatccggtcg
    11521 agcagccggc gtacggcgat cgtgcacatc tgggtggcca gccgctggct ggggcacctg
    11581 tgcgggccgg cgccccaggc gagatgggcc cgggtgctgc gtacggtgtc gcggttcagg
    11641 gcggaggcga acaggggatc ggcgtgcgca cccgagatgg acagcatgac cgggtctccg
    11701 gcggcgatcg tgaagcgccc gagcttcacg gccgtcctgg cgtagcggaa ggtcaggttg
    11761 gccagcgcgg ggttgagcag ggcgacgcgg ttgaccagct cctcgatctg ccccgacgtc
    11821 accgacgtcc gcaggtccgg gttgccgacg gcctcgacga tgacgttgca gatcaggctg
    11881 ccggtgaagt cgaggaagcc ggacagcatg aacagctcgc gcgccacctc ctcgggggtg
    11941 agggcggggg cggccgcgaa catggcggag ggcaggtcgt gaccgggccg gtggcgcttg
    12001 gtcgtcgcca gttccaggag ggcggtgttc aggcgctggt aggccccggc ggcgtcggga
    12061 ccgtccagca ggcgccactg atccatgatc atttcttcgc cgcggtcgag ggtgacgccg
    12121 aggaggtggt tggcgaccat gaggggcagc ggccgcccgt actgcgcggc caggtccgcc
    12181 catccggtgg gcgtgccttc cgtcatgacg ccgatgaggt cgtcgcagta cttcagaatg
    12241 gcgcgttcca acttctgggt gtgctcccca ccgggctcct ggaactcccg caggccggcg
    12301 atccacgcgc cccggagacc gcggtgccgg tccccgtcgt ggaagcccga gttgtcggcg
    12361 gacaggaggg ggatcagcgg ccagtcggcg gggatccggc cctcggcgaa cgccctccag
    12421 tggccgacgt gcttgctcca gaaatcgtcc gggttctgca tgatgtagcg cacctcgtcg
    12481 tacccgaagg cgaaccacac cggcacaccg tgcagctcga tcggggccac cgggccgtac
    12541 gcggcgcgga ggcgttcgtg cacgcgtgcg ggatccgctt ggtactccct cgtcagcagg
    12601 gattccaggg gcatcgacga cagatcttcc gcggccggtg ccggccatat gtcgggggtc
    12661 aaggaatcgc ccgcctttcc ggtcgcccgg acggcgccga ttgcgcgacg cccgggtctg
    12721 ggcggcgatc ttagagtgcc cggccgcgtc tgtcagcggc ccgcgggtcc aggaggcggc
    12781 actgttcctt tctcgtgatc gagcacgcgt tgccggttgt ccggcgacgt gtgccgtcgc
    12841 ggcggtgggg ccatggcggg acgctccgcc atggccccgg ccccctgtgg ggggacgtgc
    12901 tccgtcagag gccgagcccg atcagcagcg gatcgtggtc ggaggagcgg taggcgtccg
    12961 gcgcgtacag gtagggcggg ttgaactcgg tgttgtagtc catgaacctg ccctcatcgg
    13021 cgttgacgtg ccagatggtg gcgccggtca ccagcctgtt cagcttcttg tcggccaggg
    13081 cgtggtcgag ctcgcccgac aggccctcga agaggtagct gtagcggtcc tccttcttga
    13141 cgtgcttctt gctcaggctg accagcccgg cgtcctcgaa ggtgtggatg gggtcctcct
    13201 cgccgtaggc gttgatgtcg ccgacgacga gcgtgttccg cagcttgagg ctgtcgatca
    13261 gggcgagtac ggcctgggcc tgcttgaccc gcttggcgtt gaagcagctc tggccgtccc
    13321 cctggtcggc gtcggcgccg gtggcgggaa tcgagtcggg cccgtcggtg cagcccttgg
    13381 acttgaagtg gttgaccagg atcgtgaaga tctcgccctt gccgttcgcc ctgccgaagg
    13441 tctgcaccag cggcggacgg ctgaagatcg gatcggcgga ggactgcggc ccgccgatcg
    13501 gggtgacctt ggccggcttg tagatcagtg cggtctggat gaggtcggtg cccgggttcg
    13561 ggtgggtgat cgccttgtac gtgcccgcgc ccgccgcggc gttcaacgcg tcgaccaggg
    13621 cgttcagcgc gacgttgttg ttgcgctcga tctccatcag gccggccacg tcggggtcga
    13681 gagcgaggat gttggcgacc agcttcgcga gctggcggtc ccgctcggcg gcggtggtcg
    13741 cgccccggga cttcagggtg gtgaaccagt tgagcgtgtt gaggctggcc acccggacgt
    13801 tgccgccgac cctcttcggc tccgcgggcc gcgggttctc cggccggaag acgaccggct
    13861 gggtcggctc gacgcggtag acgccgaagc cgtaggtgag caccccggtc aggttcttca
    13921 cctcgtcgcc gatccggact gtgttggatc cctcggtgtg gtacggcagg gtcggcgggt
    13981 tctgcgcgtt ggagccgtcg tcgagcagga tcgaacgccg cgcgtccttc ccggtgtcca
    14041 cgcccttgcg gtcggtcggc tgccacaggc ggccgccctc ggcgagggtg atctcgccgt
    14101 accggccgag gttgtagatc tcggaggcgg ccatgtcgtc cttgaaggtg acgagcatgt
    14161 tctcgtaccg ctcgaaggtg gcgccctcct tgagcggcag attcacctca accggcttga
    14221 tcgtgccggt gccgcacacg ttcaccgccg tggccggcga gatctccgtg aggccgttgt
    14281 actcgaccgc cttgccggag acgaggacgc ggtcgccggc cttgaccggc gaggaggaga
    14341 acacgaacac gccctcggag gtcgccgggt ccttgtccgg cttggggtcc tggacgtaga
    14401 agccgccgag ctggccggcg ccctggaagg agccggtgac gacgccctcg acccggacgt
    14461 cctggccggc gacggggctg acgtcgccgt cgccctgcac ctgcgcgatc cggtgggtga
    14521 ccggcgtgtc gcacgtgggc gacgggctcg gggtggcgga gggagacggg ctcgcgctcg
    14581 gggaggggga ggcggacggc gacgggctcg ggctctcgct cggggaggcg gagggagagg
    14641 cggacgggct cgggctctcg ctcggagtgg ccgagggaga cggggacgga tccgggccgg
    14701 cgcagggggc cgccgtgctg gcgctgttgc gcggcgcggg cgccgcggcc tcgaagtcgg
    14761 cgccgttgtc gtcggtgtcg gtgcagccgc cgcccctgcg gatcgcggcg gtgccgttgg
    14821 tgagcccggg cgcgggggtg ccctcgaaga agttcgcggt gccgtagccg accaggtccg
    14881 cgacgagcgc gagctgctca tcggtgcagg gaacggtgga gccgttgcag gccaggccgg
    14941 tggtggagcg taccagcgcg agcttgcccg ccgtgccgct catgttgacg ccgccgacgt
    15001 cgtcgggcgt cggcagggag ccgctgggcg tggtgcccgc cgcgagctgg accaggtggt
    15061 actgccccgg ggcgagggtg ccactgaggt cggtcttgtt ggcggagaag ttcccggttc
    15121 cggtcgcact ggtgtactgc accgaccagc cgctcagcga gacggaggcg ccggtgcggt
    15181 tgaagagttc gacgtagtcg ttggtgaggg gggcgccgga gtttccgcct cccccgtaga
    15241 cctggctgat cactactgtt cccggcgccg cggcggcggg agcgggcgag agggcggcga
    15301 tcgagccggc ggcgaggccg gcggtgacga ggatcgcgag tgcccgaggt gttgcgcgca
    15361 tggcctgaga gtaaagccgc cttaatcagc acagaccatc ttttctatgt atgaagggtg
    15421 aacgcctgat gggcggcggc acgcacggcc cggagccccg ctgccgacaa atcgcccaaa
    15481 cgggatgaaa gttcgcccag agctatcgcc ttctgccggt tgcgtgtgct gtggcctatt
    15541 tgttggctat ttgtgacata tgcccagaat gaggcgatag ttcgcctttg cttcagcctc
    15601 ttcacgcacg tcgttcactc ctgaaatcca ctgtggccgc tcgaagacca cgccgtttta
    15661 tcggcgtctt atcgaacctg atggaaggga ctgcaccaga tgcagccagt ggcagcgaga
    15721 aagctgctgg gaggcgtgag gagacgaggg cgtctcgccg cggccgtcgt gatcgccatg
    15781 gtcgcgacgc tgctcgccgg cgccgtcgtg accgcggcgc acgccgaccc cggccccgcg
    15841 aaagcgggcc aaggacgtcc cagcccggcg ccgaccggtt cccccacccc gccgacgctc
    15901 agccccgccg gtggttcgta cctcgaaggc atggtgaagg tcgcggcggt ccccgccgcg
    15961 gccggcgaca gtgtgacgaa actggccgtc gacggcggcg cgctgaacgc cacccgtacg
    16021 gtgggcgtgt ccaggctccg tttcgacgtc ggctcgaact cgacggaggc gcggtaccac
    16081 aactacgtgc tcgtcaacgg cgcgtaccgg accgacatcg gcgacctcgt gaacgagcgg
    16141 gcgaccatcg agatcccgaa cgaacacctc gtcaagggcg agaacacgat cgagatcttc
    16201 gccgggacgg tccagagctc gtgcggcacc aactacgacg acttcgtcct gtccgacgtg
    16261 ggcctcgaac tgctcggcga ggtcgcggac ggggaggaca acccgtacac cctctccttc
    16321 ggcgacggca actgcggctc gaacaccgcg ctgctcaagc aggccgcgct gaagttcttc
    16381 gtcaagggcg acccgcaggg gacgaccggt ctcgcggcgg acctggacac cacgacgctg
    16441 gcgaacggcg agcacgccat caccgccacg accgcgtccg gggccaccgt caagaacgcc
    16501 gtgaccgtga acaacgcccc ggccggggcg ccccggctga cgcccacgga cggcacgctg
    16561 gtggcgggca ccacgccggt gtccgcgacc gtgcccgccg tgggcgcggg cggcgtctcg
    16621 gccctcaccg tcgacggcgc cgaacccgcc ggcaaggcca cactgggcga cggcgcggcg
    16681 aagttcagct tcgacgtggg cgcggacgcg atcgaggaca agtacgacga cttcctgctc
    16741 gtcaacggca agcgcgtcga cctgggcgga tcctgggtca accagcgcgt caccgtcgcg
    16801 gtcccggccc ggctcctggt gcccggcgac aacgtgatca aggtcatgac cggcgactgg
    16861 aaggcgtcct gcggcgtcga tcgcgacgac ttcaccatcg cgaacctcgg cctcgccctc
    16921 gacggcgcca ccgtgaccgg ccgtgacgtc aagccgtcgt acgacatggg cgacggcacc
    16981 tgcggcagcg gccagacgac cctccgcgag gtcgaactgc gctacacgat cgacgccccg
    17041 ggcgtccgcg tcgtccggac gctcggctcg ggcgacgcga cgctcagctt caccgtgggc
    17101 agcaactcga tcgaggcgcg ctaccagaac cacctgctcg tcaacgggcg gaaggtcgtg
    17161 ctcgacggcg acttcgtgag ccggcgcgtc gacttcacct tcccgaacga gtatctcgtg
    17221 cccggctgga acacgatcga cttcgtgacc ggcacctatc cgacgtcgtg tggcaacaac
    17281 cgcgacgact tcgcgatctc gaacatcgcg ctcacgccgg tgcggggcac ggcgagcggc
    17341 cagatgctca agggctccta cagcatgggc gacggcaact gcggcgacaa cgtgaacctg
    17401 ctgaccgaga tcgacctcga gttcctcgtg gacgcgcccg cggccggcct gcgtgcggac
    17461 ctcgacacca ccgcgatcaa ggacggcagg cacactctcg ccgcgacctc gaccacgggg
    17521 gagaaggcca cccgcacgct ggtcaccgac aacacggcgc ccaaggtcgc cgcgagcgtc
    17581 cccgccgcgg gcgagaagat caccgcctcc gtcgtgctgg acgtcacgct ggaggacgcc
    17641 tccggcgtcg tgtccgggcc ggacgtcacg ctcgacgggc aggcgatcgc gctgggcgcc
    17701 caggtgggcc ccggcctgtc gcccggcagg cacaccctcg ccgtgaccgg cgccgactcg
    17761 ctcggcaaca ccgccacccg tgagatcgcg ttcgagtccg ccggcatccc ggacgtcccc
    17821 gccgagctca ccccggcgtc cgggaccgcc gacgtgccgg gcaccgtcac gctctcggcg
    17881 aaggtcgccg agcccggcgg aggaaaggtc aaggcgacct tctccgaagc cgacattctg
    17941 accccgaacc aggcgtacca gggcgtcgtc gacgctgtcc ccacgaccct ccaggtgccg
    18001 ggcgagaaga agctcaaggc caccgggctg gagcccgccg acggcgccac gctcgacgcg
    18061 cccgccggcc gggacgtcac ctaccagcgg tacgacatcc aggtgaaggg ccatgtggac
    18121 gccccggtcc tgcgctggga gggcgtcatc gaccccgagc gcctggtgtc gctgcgggcc
    18181 tggaacacca aggcccgggc gtgggacctg ctgacgagcg cccgcggctc cgccgagggc
    18241 cagaccgccc tcaccgccgt ggtcggcgac cggtacgtcg acgggcagca ggtccacgtg
    18301 atggtgacgg gtgaggaccc gttcgccgac gacatcgacc ccggtgaccc gaacggcttc
    18361 gccgacccct ccacgtacga cttctcgatc gtccacttca ccgacacgca gtatctgtcg
    18421 gagggcgcgg tggagcagga gaccgccgag gagcgcgcgg tgtgggagtc cgcgtacgcc
    18481 gggatcgtca actggatcaa gggcaacagg gaccagcgga agatctcgta cgtcgcgcac
    18541 accggcgaca tcatcgagaa caacatcagg aagcccgccg acgaggccac ccagcgggag
    18601 gtcaccggcg agctggaggt gtcgtccaag cagcagaagg tgctggacga cgcgggcatc
    18661 cccaacggcg tgatcgccgg caaccacgac aaccagtcgg gcaccgagga cgggccggag
    18721 gcgatctaca acaagtacta cggccccggc cgctaccaga cggcggcgca gggctggcag
    18781 cacgcggagt acggcgggcc gtggaaggag ggcgacaacc agaaccacta cgacctgttc
    18841 tccgcgggcg gactggactt cgtcgtggtc ggcctgtcgt acggcgtcac gcgggaggag
    18901 gccgagtggg ccgactccgt cttcaagcgg ttccccggcc gcaacggcat cctgctctcg
    18961 cacgactacc tcgtgccgag caccaacccc gacggacggg gcgcgggatt ctcggcgccc
    19021 gacggctcga tgctctacaa gacggtggtc gagaagaacc cgaacgtctt cctcatcctc
    19081 gccgggcacg agcacggcgt ggggacgaac gtgaagccga aggtgggcca ggtcggcaac
    19141 ggcgtcgtcg aactgctggc cgactaccag ttctacacgg tctcggccga ccgcctcggg
    19201 ctcacccagg tcggcgggta caacccggac gaccagctcc agttcggcgc gagcttcttc
    19261 cgcctgctgc agttcaacgt caagcgggcg gagctgaccg tggacaccta ctcgcccctg
    19321 ctgaacgact tcggcgcggg cgagttcgac ccgctgcgcc ggtacgacgg gcgcgaggac
    19381 aacatggtgc tcccggtcga tctcaccacc cgtacgacga gcttcgccac cgactcgctg
    19441 gccatctaca agcccacccg ggtcatcggc acgagcacgg tcgaatcggg tcaggtcgcc
    19501 tcggtgacct ggaaccgcct caagggcgac acggcgtacg cctggttcgt caccgcacgc
    19561 tccaccggcg gcggcgtgac cgcctccgaa ccgagcgtgt tcgtcaccag ggacgagcac
    19621 ggccgtcccg gcaagtgggg accggactcg cctctctacc gctggttcca gcacaagaag
    19681 ggctgagcag tccgtgaccg ccgccccggg ccccgctgtc acggcggagc gcccggggcg
    19741 gctttccccc tcgaatcact cgaatcctgg agaaacagac atgtcccgta ggcgccggct
    19801 gtccgcggcc gtcctcgctc tcgcctgtgc cgtcgcctgt gccctcggtg tgctggccgc
    19861 cgccccggcg tcggcccacg acgcgaccac gaaggcgcac gccacggtga ccggaacggg
    19921 cgcggacgtc agagtcgtgc tcgacctgga gtacgacctc ctcatgaagt cggcctggct
    19981 gtacgccgag gcgtacgacg cgaaggagcg ggccgagcag ctccgccagc tgaagaagaa
    20041 ccacgccgcg gtcgtcgact acatcacccg ccggttcgcc gtcgcgtacg gcgactcgcc
    20101 gtgcacgccc acacccgtgg gcgacgcgga cgtgcgcacc cgcgacgggg tggccttcgc
    20161 ggtggtgacc ctcgcctacc gctgcgcggg cgacggagac ggtgggcaca ccgtctccag
    20221 cgcgatcttc cccgacgccg agagcttcgt gcacagcacg cagacgatcg tcggatacac
    20281 gctcgacggc acgacgggct ccgcggtgct gaccgccgcg aacccgacgc tgcgggtcgg
    20341 cgagcaccgg gcctcccacc aggtggggga gttcttcctg ctcggcgccg agcacctgct
    20401 gtccggcctc gaccacgtct tcttcctgct cgccctgctc atcggcgccc gccgcgcgcg
    20461 cgacgtcgtc gtcacggcct ccgccttcac ggccgcccac agcatcacgt tcctcctggc
    20521 ggcactcggg atcgtgcacg tgcccgcggg gatcgtcgag ccggtcatcg cggtgtcgat
    20581 catcgtcgtg gccgtcgcca acctcctcgg ccgcgacgag gacagactgg gcggatggcg
    20641 gctgccgatc gtcttcgcct tcggcctggt gcacgggctg ggcttcgcga gcgcgctgga
    20701 catcgaggag aaggggtcgt gggagctgct cctgtcgctg ctcagcttca acgccggcat
    20761 cgaggcgacc cagctcctga tcatcgccgt gctcttcccg ctgctggcgc tgctgcgtcg
    20821 tacctccgcc gcccactgga tgacagccgc gatgtcggtc cccatcgtgg cggtgagcct
    20881 ctactggtgc gtcgaccgga tcgcgctgcc cctctgacgc gcaggtcagc cggtggggcg
    20941 ggggacctgg gcgaacgtcg acagcctgaa ccaccggggc agggcgcggc gggccgcctc
    21001 cgggccctgc acctcgacgg cgccggagcg cagcgcgccg gaccaggtga ggtcgccacg
    21061 ccagatctcg gtcatccgcc gcaggccggc gatcacgctc accgtcggcg gatagccggg
    21121 gtcgt
//
