LOCUS       NZ_CP023694            31190 bp    DNA     linear   CON 13-JUL-2024
DEFINITION  Streptomyces coeruleorubidus strain ATCC 13740 chromosome, complete
            genome.
ACCESSION   NZ_CP023694
VERSION     NZ_CP023694.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces coeruleorubidus
  ORGANISM  Streptomyces coeruleorubidus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 9335698)
  AUTHORS   Lee,N. and Cho,B.-K.
  TITLE     Direct Submission
  JOURNAL   Submitted (27-SEP-2017) Biological Science, KAIST, 291 Daehak-ro,
            Daejeon 34141, South Korea
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 2.3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 50X
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_008705135.1-RS_2024_04_23
            Annotation Date                   :: 04/23/2024 03:16:00
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,499
            CDSs (total)                      :: 8,405
            Genes (coding)                    :: 8,179
            CDSs (with protein)               :: 8,179
            Genes (RNA)                       :: 94
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 73
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 229
            CDSs (without protein)            :: 226
            Pseudo Genes (ambiguous residues) :: 0 of 229
            Pseudo Genes (frameshifted)       :: 96 of 229
            Pseudo Genes (incomplete)         :: 175 of 229
            Pseudo Genes (internal stop)      :: 12 of 229
            Pseudo Genes (multiple problems)  :: 53 of 229
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 14:54:21
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7513604
            Orig. end                         :: 7544794
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP023694.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria available from Korean Collection for Type Cultures.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..31190
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="NI-siderophore"
                     /region_number="29"
                     /rules="IucA_IucC"
                     /tool="antismash"
     cand_cluster    1..31190
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="IucA_IucC"
                     /kind="single"
                     /product="NI-siderophore"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..31190
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[14000:17190]"
                     /cutoff="20000"
                     /detection_rule="IucA_IucC"
                     /neighbourhood="14000"
                     /product="NI-siderophore"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      14001..17190
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="IucA_IucC"
                     /neighbourhood="14000"
                     /product="NI-siderophore"
                     /protocluster_number="1"
     gene            complement(55..948)
                     /db_xref="GeneID:91421190"
                     /locus_tag="CP976_RS34650"
                     /old_locus_tag="CP976_34665"
     CDS             complement(55..948)
                     /EC_number="1.1.1.60"
                     /GO_function="GO:0008679 - 2-hydroxy-3-oxopropionate
                     reductase activity [Evidence IEA]"
                     /GO_process="GO:0019580 - galactarate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91421190"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1100: 3-hydroxyisobutyrate dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019985031.1"
                     /locus_tag="CP976_RS34650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_34665"
                     /product="2-hydroxy-3-oxopropionate reductase"
                     /protein_id="WP_150483862.1"
                     /transl_table=11
                     /translation="MSNPLPKIAWIGLGIMGSPMSENLIKAGYDVTGFTLEREKLDRLA
                     AAGGTAAGSIAEAVRDADVVITMVPASPQVEAIAYGPDGILENAGSGALLIDMSSITPQ
                     TSVDLAKAAKDKGIRVLDAPVSGGEAGAIEAVLSIMVGGEQADFDQAEPIFEVLGKTIV
                     LCGPHGSGQTVKAANQLIVAVNIQACAEAVVFLEKSGVDLKAALDVLGGGLAGSTVLTR
                     KKDNFLGRDFKPGFRIDLHHKDMGIVTDAARNVGAALPVGAVVAQLVASLRAQGDGGLD
                     HSALLRAVERLSGARI"
     gene            complement(971..1792)
                     /db_xref="GeneID:91421191"
                     /locus_tag="CP976_RS34655"
                     /old_locus_tag="CP976_34670"
     CDS             complement(971..1792)
                     /codon_start=1
                     /db_xref="GeneID:91421191"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020125441.1"
                     /locus_tag="CP976_RS34655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_34670"
                     /product="TIM barrel protein"
                     /protein_id="WP_150483863.1"
                     /transl_table=11
                     /translation="MGFADQRFNVNLSILFTELPLLERPAAAAAAGFTAVELWWPWVDS
                     PTPEQSELDALKKAVEDAGVQLTGLNFYAGQLPGPDRGALSIPGEESERFRANIDVAAG
                     FAASLGCTALNALYGNRVEGTDPAEQDALALENLALAARAADRIGAILLIEALNQIESP
                     AYPLVSAPAAVGVVDKVNDTTGLGNARFLMDLYHLSMNGEDLPQVIERYAAKTGHVQIA
                     DNPGRGAPGTGSLPLEDLLDRLNKAGYDGWVGLEYKPGDRPSAEAFDWLPR"
     misc_feature    1817..1831
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 16.33"
                     /tool="antismash"
     misc_feature    1818..1830
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 18.7"
                     /tool="antismash"
     gene            2158..3918
                     /db_xref="GeneID:91421192"
                     /locus_tag="CP976_RS34660"
                     /old_locus_tag="CP976_34675"
     CDS             2158..3918
                     /EC_number="3.4.21.-"
                     /GO_function="GO:0004252 - serine-type endopeptidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91421192"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007384710.1"
                     /locus_tag="CP976_RS34660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_34675"
                     /product="trypsin-like serine protease"
                     /protein_id="WP_150485624.1"
                     /transl_table=11
                     /translation="MTSSAGAATAVPNPTVEPVIGSPSLPTLEKRIAGALAGDDTPGRT
                     TEKSSLSSGTSTSGIDPKIIGGSETTISTAPWMAQLWYHDDRSTPEADDDVSFFCGGAV
                     VAPTKILTAAHCLRHDNRNYDWQAHGAVVTGTAQLPTTDSTGTTDLHGGQATAVLRQWW
                     QSGYDPVDREVGRYESDLGMLTLAVPVKATPIRMVAHGDTASYAAGTQAKVYGWGRTSS
                     TSQDLSQTLRTATLTLRSDSTCAGVYDVAYVPGRMVCAGTQSGSDTGTSAACNGDSGGP
                     LVVGGRIAGVVSWGRNCVEKGYYSVFTRVSAYAGSACRQIDDTNLSTFNGRADGKADIF
                     VRESATKTGYEKDSNGSSFGARASWGNWSGVNLVLQTDLNRDGYQDLIYRVSSTGDVYW
                     EHFVLNSARTGGSWTDTKIATGWKTRTRIIVPGDVTGDYLPDLLSVDSGGTMWIYPGKG
                     NGTFGSRFSVRTGWNQYNSVRGHGDFTGDGRADLLARQSSTGDLYLYKATGKAGSEALS
                     SRIKVRSAWTGYNAFDAVGDISGDGNADFLARTPGGTLYLYKGTGKATSEIFAPRVSVG
                     TGFQQYDIWG"
     gene            4167..4418
                     /db_xref="GeneID:91421193"
                     /locus_tag="CP976_RS34665"
                     /old_locus_tag="CP976_34680"
     CDS             4167..4418
                     /codon_start=1
                     /db_xref="GeneID:91421193"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010039055.1"
                     /locus_tag="CP976_RS34665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_34680"
                     /product="thiamine-binding protein"
                     /protein_id="WP_059419634.1"
                     /transl_table=11
                     /translation="MRLRVEFTTEPFDLDEAPAHAVVAREVVEAAELDAVDVGPFGNTA
                     EGGADAVLTAVDALLRKTLEAGATRVSLQVNVIEEGEA"
     gene            4415..4783
                     /db_xref="GeneID:91421194"
                     /locus_tag="CP976_RS34670"
                     /old_locus_tag="CP976_34685"
     CDS             4415..4783
                     /codon_start=1
                     /db_xref="GeneID:91421194"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019071176.1"
                     /locus_tag="CP976_RS34670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_34685"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_150483864.1"
                     /transl_table=11
                     /translation="MSGAGDEPFIAAVKPLVDAMGGEMIPPDEAGPDDVVLSWEGTDAV
                     AVRLPQLADSLDHILAAMERRKGMPLADLDRKAKQEVVRILEARGAFSVRHGVETVASA
                     LGVSRFTVYNYLNREKGT"
     misc_feature    4848..4861
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 16.52"
                     /tool="antismash"
     misc_feature    4848..4862
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 18.84"
                     /tool="antismash"
     misc_feature    4849..4862
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.96"
                     /tool="antismash"
     misc_feature    complement(4852..4867)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.55"
                     /tool="antismash"
     gene            4944..5453
                     /db_xref="GeneID:91421195"
                     /gene="uraD"
                     /locus_tag="CP976_RS34675"
                     /old_locus_tag="CP976_34690"
     CDS             4944..5453
                     /EC_number="4.1.1.97"
                     /GO_process="GO:0019628 - urate catabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91421195"
                     /gene="uraD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003996704.1"
                     /locus_tag="CP976_RS34675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_34690"
                     /product="2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline
                     decarboxylase"
                     /protein_id="WP_150483865.1"
                     /transl_table=11
                     /translation="MTSTSTPPGLARFNALEEHAAFTALHEACASTAWAKRLLAARPYA
                     TPEALYAASDAAMAELTAQDLAEAMAGHPPIGRPKPGDPTSAREQRGMAGASDALKAEM
                     LELNLAYQEKFGHVFLICATGRTGEQMRDAVRERIGNTPEREREIVRTELGKINRIRLA
                     RLVEED"
     misc_feature    4945..4959
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.29"
                     /tool="antismash"
     gene            5461..5856
                     /db_xref="GeneID:91421196"
                     /gene="uraH"
                     /locus_tag="CP976_RS34680"
                     /old_locus_tag="CP976_34695"
     CDS             5461..5856
                     /EC_number="3.5.2.17"
                     /GO_process="GO:0019628 - urate catabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91421196"
                     /gene="uraH"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005310076.1"
                     /locus_tag="CP976_RS34680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_34695"
                     /product="hydroxyisourate hydrolase"
                     /protein_id="WP_150483866.1"
                     /transl_table=11
                     /translation="MSTSATASVSTHILDTSAGRPAEGVAVQLSARSGRAAHWQALGGS
                     ATDADGRCKDLPALPEGTTQVRLDFAVEPYFEKKQADAQQDAPANRDSGAGVFFPEVAI
                     TFAVVPGEHYHVPLLLNPFGYSVYRGS"
     gene            5863..6786
                     /db_xref="GeneID:91421197"
                     /gene="pucL"
                     /locus_tag="CP976_RS34685"
                     /old_locus_tag="CP976_34700"
     CDS             5863..6786
                     /EC_number="1.7.3.3"
                     /GO_function="GO:0004846 - urate oxidase activity [Evidence
                     IEA]"
                     /GO_process="GO:0019628 - urate catabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91421197"
                     /gene="pucL"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018514695.1"
                     /locus_tag="CP976_RS34685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_34700"
                     /product="factor-independent urate hydroxylase"
                     /protein_id="WP_150483867.1"
                     /transl_table=11
                     /translation="MPTILGQNQYGKAENRVVKITRDGATHHIKDLNVSVSLSGDMEEV
                     HYSGSNANVLPTDTTKNTVYAFAKEHGIESAEQFGIHLARHFVTSQEPIHRARIRIEEY
                     AWERIEASDANSRFIGADEVKHSFVRKGQETRLTQITYDGSSWEVISGLKDLVVMNSTN
                     SEFWGYVKDKYTTLKEAYDRILATQVSGRWRFNWTDDDQRMPKWEKSYEQTKKHMLQAF
                     AETYSLSLQQTMYQMGARIIDNRSEIDEVRFSLPNKHHFLVDLEPFGLKNDNEVYYAAD
                     RPYGLIEATILRDGCEARIPVDLTNL"
     gene            6907..8286
                     /db_xref="GeneID:91421198"
                     /locus_tag="CP976_RS34690"
                     /old_locus_tag="CP976_34705"
     CDS             6907..8286
                     /EC_number="3.5.4.32"
                     /GO_function="GO:0016810 - hydrolase activity, acting on
                     carbon-nitrogen (but not peptide) bonds [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91421198"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Amidohydro_1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015656870.1"
                     /locus_tag="CP976_RS34690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_34705"
                     /product="8-oxoguanine deaminase"
                     /protein_id="WP_150483868.1"
                     /sec_met_domain="Amidohydro_1 (E-value: 2.6e-61, bitscore:
                     206.7, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAARRIVIENCAIATVDADDTEYASGHVVLAGNRIESVGAGKAP
                     EGLENVVRRIDASGHLVTPGLINTHHHFYQWITRGLATDHNLFDWLVALYPVWARIDEP
                     MVRAAARGSLAMMARGGVTTAMDHHYVFPQGSGDLSGAIIGAARDMGVRFTLARGSMDR
                     SEKDGGLPPDFAVETLDGALAATEDTVRRHHDSSFDAMTQVAVAPCSPFSVSTELMRDG
                     AQLARRLGVRLHTHGSETVEEEKFCHELFGMGPTDYFESTGWLGEDVWMAHCVHMNDSD
                     IAAFARTRTGVAHCPSSNARLAAGIARVPDMLAAGVPVGLGVDGTASNESGELHTELRN
                     ALLINRLGAHKEAALNARQALRLGTYGGAQVLGRAAETGSLEPGKLADLVLWKLDTLAH
                     ASIADPVTALVFGAAAPVTASFVDGRQIVEDGRLLTADEDAIARSTRDEAQRLARIAAQ
                     G"
     gene            8508..9896
                     /db_xref="GeneID:91421199"
                     /locus_tag="CP976_RS34695"
                     /old_locus_tag="CP976_34710"
     CDS             8508..9896
                     /GO_function="GO:0015205 - nucleobase transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91421199"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003993977.1"
                     /locus_tag="CP976_RS34695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_34710"
                     /product="nucleobase:cation symporter-2 family protein"
                     /protein_id="WP_150483869.1"
                     /transl_table=11
                     /translation="MADHPVDEKLPALKMATTGLQHVAAMYAGVVAPPLIVGAAIGLTA
                     TDLTFLTGACLFTAGLATFLQTIGVWKIGARLPFVNGVTFAGVAPMTAIVASTEDKSDA
                     LPVIFGAVIVAGLLGFIAAPVFCKAVRFFPPVVTGTVITLIGISLLPVAFGWAQGPDPA
                     AHDYGSATNLGLAAGTLVVVLLLRRFTRGFVKQIAVLLGLVAGTLIAIPFGATDFGPVA
                     DAAVIGFPTPFHFGAPQFQLAAILSLCVVMVVSMTESTADMLALGEIVDRPADEKTIAA
                     GLRADTLGSAISPLFNGFMCSAFAQNIGLVAMTKIRSRYVVAAGGGFLVLMGLCPMAAS
                     LIAVVPRPVLGGAGVVLFGSVAASGIQTLVRAGLEKDNNVLIVAVSLAVGIIPITAPEF
                     YHAFPETARIVLDSGISTGCVAAVLLNLVFNHLGPRDRDAHDVTHPMEAGEEITGVPRT
                     PAAP"
     gene            <10083..>10613
                     /db_xref="GeneID:91422901"
                     /locus_tag="CP976_RS43940"
                     /old_locus_tag="CP976_34715"
                     /pseudo=""
     CDS             10083..>10613
                     /codon_start=1
                     /db_xref="GeneID:91422901"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014674264.1"
                     /locus_tag="CP976_RS43940"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="CP976_34715"
                     /product="serine/threonine protein kinase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MEVTVATDVFALGQTAAFAALGRPLYGDGSAVGVLYRIVHDEPDL
                     TALPEQLRPLMARCLAADPRERADLAEIVEWCRQRLGADADAGAGPAVWRDVMGPEVTV
                     PSPADLDATRVSPATLDPTRVQRQPLVVTRPQTQPPGPEERRARRRRGALITAAAVTAG
                     ALVLTGLAWTVADA"
     gene            complement(10827..11249)
                     /db_xref="GeneID:91421200"
                     /locus_tag="CP976_RS34705"
                     /old_locus_tag="CP976_34720"
     CDS             complement(10827..11249)
                     /EC_number="3.1.2.-"
                     /GO_function="GO:0016790 - thiolester hydrolase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91421200"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 4HBT_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675829.1"
                     /locus_tag="CP976_RS34705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_34720"
                     /product="acyl-CoA thioesterase"
                     /protein_id="WP_150483870.1"
                     /sec_met_domain="4HBT_2 (E-value: 6.8e-23, bitscore: 80.3,
                     seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEPFSVPVTVRGYETDVQGHLNQSVYLNYAEHARWSLLRAAGIS
                     QSALIGSGVGPVALETTIRYKRELLAGDEVEVTCAFAWGEGKTFRIEQTVRKSDGTVAA
                     EITAVGGLLDLKARKLVPGPQEYFRKLASEPGVLGL"
     misc_feature    complement(11136..11138)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(11315..11944)
                     /db_xref="GeneID:91421201"
                     /locus_tag="CP976_RS34710"
                     /old_locus_tag="CP976_34725"
     CDS             complement(11315..11944)
                     /codon_start=1
                     /db_xref="GeneID:91421201"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010039039.1"
                     /locus_tag="CP976_RS34710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_34725"
                     /product="hypothetical protein"
                     /protein_id="WP_150483871.1"
                     /transl_table=11
                     /translation="MTRPPTAAQRRVIDAADPVTGRLRGTESQLAALVKRGLAFRHPRP
                     PHDHFLTPEGHRVRQGVMQVPEPAAEAPATAGVFAASVGGEEAAQETGPARRREVHSAW
                     QGLLELRRMTNPDGAVERPCGWERTHLVQAAALALEAAGHRPAGRDDGGYRVRETPQPE
                     AVAVYEPDGEALRTCAATLEGAGWQVSEHSEPRTGTRYLLASPRRA"
     gene            complement(12027..13235)
                     /db_xref="GeneID:91421202"
                     /locus_tag="CP976_RS34715"
                     /old_locus_tag="CP976_34730"
     CDS             complement(12027..13235)
                     /EC_number="2.6.1.-"
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (33-390). E-value:
                     2.5e-52. Score: 170.1. Matches aSDomain:
                     nrpspksdomains_CP976_RS34715_Aminotran_1_2.1"
                     /codon_start=1
                     /db_xref="GeneID:91421202"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019: aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007390030.1"
                     /locus_tag="CP976_RS34715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_34730"
                     /product="pyridoxal phosphate-dependent aminotransferase"
                     /protein_id="WP_150483872.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 3.3e-50, bitscore:
                     170.2, seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 8.5e-06,
                     bitscore: 24.2, seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_5 (E-value: 1.5e-05, bitscore:
                     23.0, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEFRQSSKLSEVCYEIRGPVIEHANALEEAGHSVLRLNTGNPALF
                     GFEAPEEILQDMIRMLPQAHGYTDSRGILPARRAVAQRYQTLGLEVGVDDVFLGNGVSE
                     LVSMAVQALIEDGDEILIPAPDFPLWTAVTTLAGGKAVHYLCDEQADWYPDLDDMASKI
                     TDRTKAVVIINPNNPTGAVYPKEIVEGILDLARRHGLMVFADEIYDQILYDDAVHHSAA
                     ALAPDLVVLTFCGLSKTYRVAGFRSGWLVVTGPRQHAKDYLEGLTMLASMRLCANAPAQ
                     YAIQAALGGRQSIRDLTLPGGRLREQRDVAWEKLNEIPGVTCVKPKGALYAFPRLDPKV
                     HKIHDDEKFVLDLLLREKIQVVQGTGFNWPAPDHFRILTLPHADDLEAAIGRIGRFLGG
                     YRQ"
     aSDomain        complement(12066..13136)
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CP976_RS34715_Aminotran_1_2.1"
                     /evalue="2.50E-52"
                     /label="CP976_RS34715_Aminotran_1_2.1"
                     /locus_tag="CP976_RS34715"
                     /protein_end="390"
                     /protein_start="33"
                     /score="170.1"
                     /tool="antismash"
                     /translation="VLRLNTGNPALFGFEAPEEILQDMIRMLPQAHGYTDSRGILPARR
                     AVAQRYQTLGLEVGVDDVFLGNGVSELVSMAVQALIEDGDEILIPAPDFPLWTAVTTLA
                     GGKAVHYLCDEQADWYPDLDDMASKITDRTKAVVIINPNNPTGAVYPKEIVEGILDLAR
                     RHGLMVFADEIYDQILYDDAVHHSAAALAPDLVVLTFCGLSKTYRVAGFRSGWLVVTGP
                     RQHAKDYLEGLTMLASMRLCANAPAQYAIQAALGGRQSIRDLTLPGGRLREQRDVAWEK
                     LNEIPGVTCVKPKGALYAFPRLDPKVHKIHDDEKFVLDLLLREKIQVVQGTGFNWPAPD
                     HFRILTLPHADDLEAAI"
     gene            13322..13948
                     /db_xref="GeneID:91421203"
                     /locus_tag="CP976_RS34720"
                     /old_locus_tag="CP976_34735"
     CDS             13322..13948
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91421203"
                     /gene_functions="regulatory (smcogs) SMCOG1167:
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016431824.1"
                     /locus_tag="CP976_RS34720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_34735"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_150483873.1"
                     /transl_table=11
                     /translation="MPPRRSYDQYCSAARALDVVGDRWTLLIVRELLAGPRRYTDLHAD
                     LPGVSTDVLASRLKDMERDGLATRRRLPPPGAAFVYELTTRGRELLPVLQALGEWGRAE
                     LGDRRPTDAVRAHWFALPLLRLLDGEGLVEVRLEEGLFHLHAGAEEGPVYGDGPAPGEP
                     DARLVLDTGTCTALSRGELSLARAVREGRVEVSGEGTLAKALREA"
     gene            complement(14001..15497)
                     /db_xref="GeneID:91421204"
                     /locus_tag="CP976_RS34725"
                     /old_locus_tag="CP976_34740"
     CDS             complement(14001..15497)
                     /codon_start=1
                     /db_xref="GeneID:91421204"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NI-siderophore: IucA_IucC"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010039027.1"
                     /locus_tag="CP976_RS34725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_34740"
                     /product="IucA/IucC family siderophore biosynthesis
                     protein"
                     /protein_id="WP_150483874.1"
                     /sec_met_domain="IucA_IucC (E-value: 1.3e-32, bitscore:
                     112.2, seeds: 168, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHRSPTAEAEVADELAVVRPGLLPRYEAEVPGARAAVLSRLWRGL
                     AHDPLPWVTRREQGGDGLTLHLSDGRRLHGPRPDPYATGAYVTVLRLDEAEYDDPARLV
                     TDLAVPHSASFAAELAHSGASLALSRAGQEGRVTDGWPEHDWEWEQRIVDGHPFHPTCR
                     SRPGFSVAEQLAYGPEHRPVVELGLVPVRAEECLVTGAWPRDLRDGGRVVLPVHPWQAA
                     HVLKRVCEERRAGHPLMALRTLALPGGSHVKTSLSARLTSSVRDISLASVAASAVLSEF
                     AETPAAHTDGLLHVTRTLGAAAAGSPDFAAVLREPPEAYARDGERVLPVAALATTELPR
                     SPAWLAGFARLALTVGLRLLELGVALEAHGQNLLVILSPAGDPLRLVYRDLADIRVSPA
                     RLARHGIAVPDLPARMVTDDERTLRRKLFGSLVAGALAGTAGSGAALTAALETAVRELP
                     RTPGLAALRADPLPTKALTLMRLSPQTAGDQWAELPNPLS"
     gene            15625..17190
                     /db_xref="GeneID:91421205"
                     /locus_tag="CP976_RS34730"
                     /old_locus_tag="CP976_34745"
     CDS             15625..17190
                     /GO_process="GO:0019290 - siderophore biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91421205"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NI-siderophore: IucA_IucC"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003993985.1"
                     /locus_tag="CP976_RS34730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_34745"
                     /product="IucA/IucC family protein"
                     /protein_id="WP_150485625.1"
                     /sec_met_domain="IucA_IucC (E-value: 2.7e-40, bitscore:
                     137.4, seeds: 168, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPPPDGDDSAHGDCAHGDSAHGVSAQDDPVTDGLAERADAYAAVP
                     LLNCLLREVARPVSETGEHRVHHLPGGDRLLRVRGTRRPAQPEVRVAGGWHRVGHTELV
                     KLVAEELRRHTGLSNHELPAEMIDSRDAVAALLAARARATPPDDPYLRSEQCLLTGHTH
                     HPAPKARGGGPAAGWLPYAPEAYARFPLTLLGLREDTVVEEGDTSPLDALGTAPPGYRL
                     LPAHPWQLDLAGPELADAFADGRLVRLGTTAFGTWPTAAIRTLYAPGPDLFLKFSLDVR
                     ITNDIRRLWRHDLLALRRTDAAVRAAFETFEGPPAWLSDRGYRTADFAFEALAVLVRDG
                     FGGRLLPGATPLLAAGLVEGFDGSPLDRAADPGAWWSAYLAQVVPPAMTAFARHGVVIE
                     AHLQNTLVAVDAEGTPVQALYRDAEGVKLLPDVEREAGWERLVYCLVVNHLGEIAGALA
                     ERHPGLDPWPAARRELARHDVPEIPALLASPTLPGKTNLLLRWTGADGADARYLPLPNP
                     LRGA"
     gene            complement(17198..17926)
                     /db_xref="GeneID:91421206"
                     /locus_tag="CP976_RS34735"
                     /old_locus_tag="CP976_34750"
     CDS             complement(17198..17926)
                     /codon_start=1
                     /db_xref="GeneID:91421206"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010039014.1"
                     /locus_tag="CP976_RS34735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_34750"
                     /product="hypothetical protein"
                     /protein_id="WP_150483875.1"
                     /transl_table=11
                     /translation="MTWLLMGVATLVVGVAMTLEVRGALDREREFRAAPACASVPVKAS
                     GCRWEQEFTVRKADLNRGRRNGSPEAELLLPSGKPWYVTFRQTDPVVSELEPGERVVGL
                     IWHGQVVGVRDADGRRQQTSHGPVGWSEDRLGGALACFAFGLSALVGGAWPLFARGDRR
                     HATAGGVVRWHGVCMGVAALFTLWAQSANGWPFWAVPAIWGPLALLGLASMTAFVIAAL
                     RGDMDDEAPSAHEPSPTATA"
     gene            18185..19459
                     /db_xref="GeneID:91421207"
                     /gene="cbiE"
                     /locus_tag="CP976_RS34740"
                     /old_locus_tag="CP976_34755"
     CDS             18185..19459
                     /GO_function="GO:0046025 - precorrin-6Y
                     C5,15-methyltransferase (decarboxylating) activity
                     [Evidence IEA]"
                     /GO_process="GO:0046140 - corrin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91421207"
                     /gene="cbiE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TP_methylase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005484174.1"
                     /locus_tag="CP976_RS34740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_34755"
                     /product="precorrin-6y C5,15-methyltransferase
                     (decarboxylating) subunit CbiE"
                     /protein_id="WP_150483876.1"
                     /sec_met_domain="TP_methylase (E-value: 1.3e-20, bitscore:
                     73.2, seeds: 87, tool: rule-based-clusters)"
                     /sec_met_domain="PCMT (E-value: 3.1e-05, bitscore: 22.8,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPAPDAPTAAVTVVGLGADGWAGLPDASRTALREAEVVIGGPRQ
                     LDLLPPECTGQRLAWPSPLRPAVPGLLAAHAGRRIAVLASGDPMFYGIGRALAEETGAL
                     RVLPHPSSVSYAAARLGWPLEDVEVVTLVGRPAARLAAALHDGRRLLVLSADATTPGEV
                     AALLRDRGFGPSRMRVLEQLGGDRERTTDEATADDWPGGRQPGDPLNIVAVECRRAPDA
                     LRLGAVPGLPDEAYEHDGQLTKRHIRAATLGVLAPAPGELLWDIGGGSGSIAVEWMRTH
                     PSCRAVTVERDPARAERITRNADRLGVPGLRVVTGAAPAVLAELPPPHAVFIGGGLTAP
                     GLLDACWEALPGGGRLVANTVTLESEALLADAHRRHGGELVRLAVAHAVPVGGFTGWRQ
                     AMPVTQWAVRKTPDTSSGPSSGADR"
     gene            19456..20205
                     /db_xref="GeneID:91421208"
                     /gene="cobM"
                     /locus_tag="CP976_RS34745"
                     /old_locus_tag="CP976_34760"
     CDS             19456..20205
                     /EC_number="2.1.1.133"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0046026 - precorrin-4
                     C11-methyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0009236 - cobalamin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91421208"
                     /gene="cobM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TP_methylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008409267.1"
                     /locus_tag="CP976_RS34745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_34760"
                     /product="precorrin-4 C(11)-methyltransferase"
                     /protein_id="WP_150483877.1"
                     /sec_met_domain="TP_methylase (E-value: 9.7e-42, bitscore:
                     142.2, seeds: 87, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVYFIGAGPGAADLITVRGARTLAACRVCLYAGSLVPRELLAEC
                     PPDARLVDTAQLDLDQITAELLRAHEEGHDVARLHSGDPAVFSAVAEQMRRLDAAGVPY
                     EVVPGVPAFAAAAASLKRELTVPTVGQTVILTRVANRATAMPEGEDLATLGRSGALIVL
                     HLAAKYVDRVVEELLPHYGADCPAAVVAYASRPDELIIRGTLDEIGGKTKEAGVLRTAV
                     IMVGRTLGAEQFRDSHLYSPERERHVC"
     gene            complement(20234..21352)
                     /db_xref="GeneID:91421209"
                     /locus_tag="CP976_RS34750"
                     /old_locus_tag="CP976_34765"
     CDS             complement(20234..21352)
                     /EC_number="2.1.1.195"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_process="GO:0009236 - cobalamin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91421209"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010039004.1"
                     /locus_tag="CP976_RS34750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_34765"
                     /product="cobalt-precorrin-5B (C(1))-methyltransferase"
                     /protein_id="WP_150483878.1"
                     /transl_table=11
                     /translation="MSSEVKGGRRAQLEHTGLRPGWTTGACATAATTAAYTALLTGEFP
                     DPVTITLPKGQTPSFALAVEELGDGHAMAGVVKDAGDDPDVTHGALVRVTVRRLPAGTG
                     VVFKAGPGVGTVTRPGLPLPVGEPAVNPVPRQMMRDHVAEVAARHGGPGDVEITVSVDH
                     GEEIARSTWNPRLGILGGLSILGTTGIVVPYSCSAWIDSIRRGVDVARAAGRTHVAGCT
                     GSTSEKTVVAEYGLPEDALLDMGDFAGAVLKYIRRHPVERLTICGGFAKLSKLAAGHLD
                     LHSARSQVDKGFLAELARRGGADEVLAAQVADANTGLAALQSCLAAGVPLGDLVATTAR
                     DEALTVLRGAPVVVDVICIDRAGTVVGRSAPA"
     gene            21371..22135
                     /db_xref="GeneID:91421210"
                     /locus_tag="CP976_RS34755"
                     /old_locus_tag="CP976_34770"
     CDS             21371..22135
                     /EC_number="1.3.1.106"
                     /GO_function="GO:0016994 - precorrin-6A reductase activity
                     [Evidence IEA]"
                     /GO_process="GO:0009236 - cobalamin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91421210"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010039002.1"
                     /locus_tag="CP976_RS34755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_34770"
                     /product="cobalt-precorrin-6A reductase"
                     /protein_id="WP_150483879.1"
                     /transl_table=11
                     /translation="MRVLILGGTTEARRLAELLHDTPGLTLTSSLAGRVASPRLPPGEV
                     RIGGFGGAEGLAAWLREHRVDVLIDATHPFAGTISFHAARAAATAHVPLLALRRPGWVP
                     VEGDDWHDAGSLEEAARLLPALGRRVFLTTGRMGLAAFAGLDDLWFLVRSVDAPEAPHP
                     ARMEVLLDRGPFTLDGERELLRRHRVDVVVTKDSGGAATAPKLTAAREAGLPVLVIRRP
                     PVPEGVPVVTGPEEAARWVGEWFQGRGLPAGG"
     gene            complement(22314..23822)
                     /db_xref="GeneID:91421211"
                     /locus_tag="CP976_RS34760"
                     /old_locus_tag="CP976_34775"
     CDS             complement(22314..23822)
                     /EC_number="2.1.1.130"
                     /GO_function="GO:0030788 - precorrin-2
                     C20-methyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0009236 - cobalamin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91421211"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TP_methylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010038998.1"
                     /locus_tag="CP976_RS34760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_34775"
                     /product="precorrin-2 C(20)-methyltransferase"
                     /protein_id="WP_150483880.1"
                     /sec_met_domain="TP_methylase (E-value: 1.3e-49, bitscore:
                     167.9, seeds: 87, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSGKQSTTGRLYGVGLGPGDPSLMTVRAVEVIAEADVIAYHSARH
                     GRSIARSIAAKHIRADHIEERLVYPVTTETTDHPGGYQGAMEEFYAEASARLAAHLDAG
                     RTVAVLAEGDPLFYGSYMHMHKRLAHRYDTEVIPGVTSVSAAAARLGTPLAEGEEVLTI
                     LPGTLPEEELTARLASTDAAVVMKLGRTFTKVRGALEASGRLGDARYVERATMAGERLA
                     ELAEVDAESVPYFSVAVLPSQVDTERPQARERGEVVVVGTGPAGPLWLTPETRGALAAA
                     DDLIGYTTYLDRVPRRPGQVRHGSDNRVESERAEFALDLARRGRRVAVVSGGDPGVFAM
                     ATAVLEAASHEEYADVPVRVLPGVTAANAAAARAGAPLGHDYATISLSDRLKPWEVIAE
                     RLHAAASADLVLALYNPGSRSRTWQVGKARELLLEHRAPDTPVVVARDVGGTGERVRIV
                     RLADLDPAEVDMRTILLVGSSQTRAVRRGDGEEIVWTPRRYPEA"
     gene            complement(23819..24493)
                     /db_xref="GeneID:91421212"
                     /locus_tag="CP976_RS34765"
                     /old_locus_tag="CP976_34780"
     CDS             complement(23819..24493)
                     /EC_number="5.4.99.61"
                     /GO_function="GO:0016993 - precorrin-8X methylmutase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009236 - cobalamin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91421212"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010038994.1"
                     /locus_tag="CP976_RS34765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_34780"
                     /product="precorrin-8X methylmutase"
                     /protein_id="WP_190146823.1"
                     /transl_table=11
                     /translation="MTTPTTTESSEKTTVTTYDYEKDGAAIYRQSFATIRAEADLAALP
                     ADVSQVAVRMIHACGMVDLVRDLAYTPAVVARARAALRAGAPIFTDVQMVASGVTRKRL
                     PAGNDVLCTLSDPSVPELAAKLGTTRSAAAMELWRDRLEGSVVAVGNAPTALFRLLEMI
                     EEGAPRPAAVIGVPVGFVGAAESKDALAAHPSGLEHLVVRGRRGGSAIAAAALNAIASE
                     EE"
     gene            complement(24490..25776)
                     /db_xref="GeneID:91421213"
                     /gene="cobG"
                     /locus_tag="CP976_RS34770"
                     /old_locus_tag="CP976_34785"
     CDS             complement(24490..25776)
                     /EC_number="1.14.13.83"
                     /GO_function="GO:0016709 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen, NAD(P)H as one donor, and incorporation
                     of one atom of oxygen [Evidence IEA]"
                     /GO_process="GO:0019250 - aerobic cobalamin biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91421213"
                     /gene="cobG"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010038992.1"
                     /locus_tag="CP976_RS34770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_34785"
                     /product="precorrin-3B synthase"
                     /protein_id="WP_190146844.1"
                     /transl_table=11
                     /translation="MLAAMSTPALRSSPQATAVSRDRGDACPGTLRLHAADDGALARVR
                     VPGGVLTVRQARALADVAERLGDGDLHLTSRGNVQLRGLDGGCAGELAGLLDAAGLLPS
                     RGHERVRNIVASPLSGLDGRGALDVRPWLTALDAALCASEAAQALSGRFLFALDDGRGD
                     VAGLGADVTVRATADGGARLGLGAAGDALHVTAGEAARAALLAAETFLEAARASGAQVW
                     RVEELALADGELLDAVGRRLTAEGIRHERRGRETGRADGPPPGVVGDGLSVHVPLGRLS
                     VRQWRELTHVAAGELRLTPWRGVVLPTPRTRADESLARLAATGLVTDPGSPWLRVGACV
                     GRPGCAKSQADVRTDAAGTLGAIAPHGLPLYWSGCERRCGHPRGDRVDVVAAPDGGYRL
                     STAVRGEEPRTSTMNDPARLAAALAEITS"
     misc_feature    25840..25854
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.75"
                     /tool="antismash"
     regulatory      25878..25954
                     /bound_moiety="adenosylcobalamin"
                     /db_xref="RFAM:RF00174"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00174"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="cobalamin riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     gene            26011..29637
                     /db_xref="GeneID:91421214"
                     /gene="cobN"
                     /locus_tag="CP976_RS34775"
                     /old_locus_tag="CP976_34790"
     CDS             26011..29637
                     /EC_number="6.6.1.2"
                     /GO_function="GO:0051116 - cobaltochelatase activity
                     [Evidence IEA]"
                     /GO_process="GO:0009236 - cobalamin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91421214"
                     /gene="cobN"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1263: cobaltochelatase subunit CobN"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010038990.1"
                     /locus_tag="CP976_RS34775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_34790"
                     /product="cobaltochelatase subunit CobN"
                     /protein_id="WP_150483882.1"
                     /transl_table=11
                     /translation="MLHSSGERLPNPRILLLSTSDTDLLSARAAAGPVPYRFANPSRLA
                     LDDLPALLDGVGLVVVRLLGGIRAWQDGLDLLLADGRPVVVLTGEQAPDAQLMASSTVP
                     IGIAAEAHAYLAHGGPANLEQLARFLSDTVLLTGHGFEAPEAAPTWGPLPREGRDTDGP
                     TVAVLYYRAHHMSGNTAFAGALCDAIEDAGGRPLPLYVASLRAPEPELIEELRAADAIV
                     TTVLAAGGTKPAEASAGGDDESWDAGALTALDVPILQALCLTGSRTDWADNDEGVSPLD
                     AASQIAVPEFDGRLITVPFSFKEIDADGLPAYVADPERAARVAGIAVRHARLRHIRPAD
                     KRLALVLSAYPTKHSRIGNAVGLDTPASAIALLRRLRDEGYDFGTDAEVPGLASGDGDE
                     LIRALIEAGGHDQDWLTEEQLARNPVRIPAADYRRWFATLPGELRTAVEEHWGPAPGEM
                     FVDRSRDPEGDIVLAALRFGNLLILIQPPRGFGENPIAIYHDPDLPPSHHYLAAYRWIA
                     ARTEDGGFGADAMIHLGKHGNLEWLPGKNAGLSAACGPDAALGDLPLIYPFLVNDPGEG
                     TQAKRRVHATLVDHLVPPMARADSYGDIARLEQLLDEYAQISSMDPAKLPAIRAQIWTL
                     IQAARLDHDLGLEDRPDDDGFDDFLLHVDGWLCEVKDAQIRDGLHVLGNPPQGADRVNL
                     VLAILRARQIWGGATALPGLREALGLDESAATRTTADEAEEQARALVQAMEDAGWDPAA
                     VPTEHGEQVAAILRFAAREVVPRLAATTAEVDHTVHALAGGFVPAGPSGSPLRGLVNVL
                     PTGRNFYSVDPKAVPSRLAWETGQALADSLLERYRADNGDWPTSVGLSLWGTSAMRTAG
                     DDVAEALALLGIRPVWDDASRRVTGLEPVPYEELGRPRIDVTLRISGFFRDAFPHTIGL
                     LDDAVRLAASLDEPAEANHVRAHVQADVASHGDERRATTRIFGSRPGTYGAGLLQLIDS
                     RDWRTDADLAEVYTVWGGYAYGRELDGRPAREEMETAYKRIEVAAKNTDTREHDIADSD
                     DYFQYHGGMVATVRALRGTAPEAYIGDSTRPETVRTRTLVEETSRVFRARVVNPKWIEA
                     MRRHGYKGAFELAATVDYLFGYDATTGVIADWMYDKLTETYVLDPANREFLQEANPWAL
                     HGIAERLLEAESRGMWEKPDPAVLEGLRQVYLETEGDLEGDG"
     gene            complement(29651..30340)
                     /db_xref="GeneID:91421215"
                     /locus_tag="CP976_RS34780"
                     /old_locus_tag="CP976_34795"
     CDS             complement(29651..30340)
                     /GO_function="GO:0000287 - magnesium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0050532 - 2-phosphosulfolactate
                     phosphatase activity [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91421215"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007451589.1"
                     /locus_tag="CP976_RS34780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_34795"
                     /product="2-phosphosulfolactate phosphatase"
                     /protein_id="WP_150483883.1"
                     /transl_table=11
                     /translation="MIGTDTRFLGIPELVEAPSVAVVVDVMRAFTVAAWAFGQGAEKIV
                     LAESLDDALALKARHPDWAALKDGPPAPGFDLVNSPGLLRSADLGGRTVVQKTTAGTVG
                     ALAVKEASLVLCAGFVVAEATARVLRTRESDGVTFVVTGEDGQADEDLACAQYIARRTT
                     EDATDAAGFVRRAAASRAAAELAQGVRQGVHSDDVALCLEVDRFPFAMVAALEGSLMVL
                     RPAHPAG"
     misc_feature    complement(30315..30329)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.83"
                     /tool="antismash"
     misc_feature    30431..30445
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.29"
                     /tool="antismash"
ORIGIN
        1 gcccggggta ggagggaccc tcgggccatg agggccgacg agggtctgcg acggtcagat
       61 ccgggcgccg gagagccgct ccacggcccg cagcagcgcc gagtggtcca ggcctccgtc
      121 gccctgcgcg cgcagggacg cgaccagctg ggcgaccacg gcgccgacgg gcagggccgc
      181 gccgacgttg cgggcggcgt ccgtgacgat gcccatgtcc ttgtggtgca ggtcgatccg
      241 gaagcccggc ttgaagtccc ggccgaggaa gttgtccttc ttgcgggtca gtacggtcga
      301 gcccgcgagg ccgccgccca ggacgtccag ggccgccttc aggtccacgc cggacttctc
      361 caggaagacc acggcctcgg cgcacgcctg gatgttcacg gcgacgatca gctggttggc
      421 ggccttcacg gtctggccgg agccgtgcgg gccgcacagc acgatggtct tgcccagcac
      481 ctcgaagatc ggctcggcct ggtcgaagtc ggcctgctcg ccgccgacca tgatcgacag
      541 cacggcctcg atcgcaccgg cctcaccgcc ggacaccggg gcgtccagga cgcggatgcc
      601 cttgtccttc gccgccttcg ccaggtcgac cgaggtctgc ggggtgatcg aggacatgtc
      661 gatcaggagg gcgccggacc cggcgttctc caggatgccg tcggggccgt aggcgatggc
      721 ctcgacctgc ggggaggcgg gcaccatcgt gatgacgacg tcggcgtccc gcacggcctc
      781 ggcgatcgaa ccggcggccg tgccaccggc ggcggcgagg cggtccagct tctcccgctc
      841 cagggtgaat ccggtgacgt cgtagcccgc cttgatcagg ttctcggaca tgggggagcc
      901 catgatgccg aggccgatcc aggcgatctt gggcagtggg ttgctcatgg tgtgcctttc
      961 ggtgcggggg tcagcggggc agccagtcga aggcctcggc gctggggcgg tcgcccggct
     1021 tgtactcgag gccgacccag ccgtcgtaac ccgccttgtt cagccggtcg aggaggtctt
     1081 cgaggggcag cgagcccgtc ccgggggcgc cgcggccggg gttgtcggcg atctggacgt
     1141 ggccggtctt cgcggcgtac cgctcgatca cctgcggcag gtcctcgccg ttcatggaca
     1201 ggtggtagag gtccatgagg aagcgggcgt tgcccagtcc cgtcgtgtcg ttgaccttgt
     1261 cgacgacgcc gacggcggcc ggtgccgaca ccagcggata cgccggcgac tcgatctggt
     1321 tcagcgcctc gatcagcagg atcgcgccga tccggtcggc ggcccgggcc gcgagcgcca
     1381 ggttctccag cgcgagcgcg tcctgctcgg ccgggtccgt gccctcgacg cggttgccgt
     1441 acagggcgtt gagcgccgtg cagcccaggg aggcggcgaa gccggccgcc acgtcgatgt
     1501 tggcgcggaa cctctccgac tcctcgcccg ggatcgacag ggcgccacgg tcggggccgg
     1561 gcagttgacc ggcgtagaag ttgaggcccg tgagctggac gccggcgtcc tcgacggcct
     1621 tcttcagcgc gtcgagctcc gactgttcag gggtgggcga gtcgacccag ggccaccaca
     1681 gctcgaccgc cgtgaagccg gccgcggcgg cggccgcggg acgctccagg agcgggagtt
     1741 ccgtgaagag gatcgacagg ttgacgttga agcgctggtc tgcgaatccc atcgggccgc
     1801 gctcccttcc gctagtttcg cattatggaa gttgctttct gcttaccgga agactgccgc
     1861 cgggcgtcgt ggcttgtcaa ggggcgggag ctgcgttggg tcgtgatccc gtggcctgga
     1921 catgtgtgag gtccaccgtc ctgggcggcg cgaggtcgcg gctcggcggg agagtgacgg
     1981 aggccggcct ttcggcgctg agcaggaggg acgcgactcg cgtccctcct gtctcatgtt
     2041 cctctggggg ggactccttt gatcacgaca ccgtccggcg gccgtcacag acgccggata
     2101 cgcatcgccc tgcccgtcgt cgccgccggc gtcgccgcgg ccgtcgccgc cgcgctgatg
     2161 acctcatccg ccggtgcggc caccgccgtg ccgaacccga cggtcgagcc ggtcatcggc
     2221 tcgccctcgc tccccaccct ggaaaagcgc atcgcgggcg ccctcgccgg cgacgacacc
     2281 ccggggcgga cgaccgagaa gtcgtcgctc agctccggca cgagcacgtc gggcatcgac
     2341 ccgaagatca tcggtggcag cgagaccacc atcagcacgg ccccgtggat ggcccagctc
     2401 tggtaccacg acgacaggag cacccccgag gccgacgacg acgtgagctt cttctgcggt
     2461 ggcgcggtcg tggcaccgac gaagatcctt accgccgccc actgcctcag gcacgacaac
     2521 aggaactacg actggcaggc ccacggcgcc gtcgtcacgg gtaccgctca actgcccacc
     2581 accgactcca ccggcaccac cgacctgcac ggcggccagg ccacggccgt gctgcgccag
     2641 tggtggcaat cggggtacga cccggtggac agggaggtgg ggaggtacga gagcgacctc
     2701 ggcatgctca ccctggccgt cccggtcaag gccaccccga tccgcatggt cgcccacggc
     2761 gacaccgcct cgtacgccgc cggcacccag gccaaggtct acggctgggg ccgtaccagc
     2821 tccaccagcc aggacctgtc ccagacgctg cggacggcca cgctgaccct gcgctccgac
     2881 agcacctgcg ccggcgtcta cgacgtggcc tacgtcccgg ggcgcatggt ctgcgcgggc
     2941 acgcagagcg ggagcgacac cggtaccagc gcggcgtgca acggagactc cggcggcccg
     3001 ctcgtggtgg gcggcaggat cgccggagtg gtctcctggg gcaggaactg cgtggagaag
     3061 ggctactaca gcgtcttcac cagagtgagt gcctacgccg gctccgcctg caggcagatc
     3121 gacgacacga acctgagcac cttcaacggc agggccgacg gaaaggccga catcttcgtc
     3181 cgggagtccg ccacgaagac cggctacgag aaggactcca acggcagctc cttcggcgcc
     3241 cgcgcctcct ggggcaactg gagcggcgtc aacctggtcc ttcagacgga cctcaaccgg
     3301 gacggctacc aggacctgat ctaccgggtc agctccaccg gtgacgtgta ctgggaacac
     3361 ttcgtgctca acagcgcccg cacgggcggc tcgtggaccg acacgaagat cgccaccggc
     3421 tggaagaccc gtacccggat catcgtgccg ggcgacgtca ccggcgacta cctgcccgac
     3481 ctgctgtcgg tggactccgg cgggaccatg tggatctacc cgggcaaggg caacggcacc
     3541 ttcggctcgc gcttctcggt ccgcaccggc tggaaccagt acaactccgt gcgcggccac
     3601 ggcgacttca ccggtgacgg cagagccgat ctgctcgccc gccagtccag caccggcgac
     3661 ctgtacctgt acaaggccac cggcaaggcc ggctccgagg ccctctcctc ccggatcaag
     3721 gtgcgcagcg cctggaccgg ctacaacgcc ttcgacgcgg tcggcgacat cagcggtgac
     3781 ggcaacgccg acttcctggc ccgcaccccc ggcggcacgc tctacctcta caagggcacc
     3841 gggaaggcga cctccgagat cttcgctcct cgggtctcgg tcggcaccgg tttccagcag
     3901 tacgacatct ggggctgaaa ccgcaggtga gcgaggctca ccccgccggt aacggtcaca
     3961 cacggcgccc atcgccgccc gcggtgggcg ctgggcgccg tgtgcccagc cctccccttc
     4021 ccggccacga ctcccggcgg tggaggacga tggagaccga tggaggacgg gtgcccgcgc
     4081 gcggaacgcg gagtgcccgc gcagccggtc cggtccgccc cggggtcggc tagggtcgca
     4141 caggtcacaa cggttctggg ggcagtatgc gactgagagt ggagttcacc accgagccct
     4201 tcgacctcga tgaggcgccc gcgcacgcgg tggtcgcccg cgaggtcgtg gaggccgccg
     4261 aactggacgc agtggacgtg ggcccgttcg gcaacaccgc cgagggcggc gccgacgcgg
     4321 tgctcaccgc cgtggacgcc ctgctccgca agaccctgga ggcgggcgcc acccgggtct
     4381 cgctccaggt caacgtgatc gaggagggcg aggcatgagc ggcgccgggg acgagccgtt
     4441 catcgcggcg gtgaagcccc tggtcgacgc catgggcggc gagatgatcc cgcccgacga
     4501 ggcaggcccc gacgacgtcg tcctgtcctg ggagggcacc gacgccgtcg ccgtacggct
     4561 gccgcagctc gccgactccc tcgaccacat cctcgccgcc atggagcgcc gcaagggcat
     4621 gccgctggcc gacctggacc gcaaggccaa gcaggaggtc gtacggatac tcgaggcgcg
     4681 cggcgccttc tccgtacggc acggggtgga gaccgtggcg agcgccctgg gcgtcagccg
     4741 cttcaccgtc tacaactacc tcaaccgcga gaagggcacc tgaccgggcc catgccctga
     4801 ccgggctcat gcccggtttc gccgcctcgc cgggtttcga cacacggaat tttcaacaaa
     4861 ctgttgacgt gctgtcgcgg gagggcgtta gctatcggca cgcccgttca gcacgaaggc
     4921 cgtacccggc cacggaggct cccgtgactt ccacttccac gccgccgggc ctggcccggt
     4981 tcaacgccct cgaggagcac gcggccttca ccgcgctcca cgaggcgtgc gcctccacgg
     5041 cgtgggcgaa gcggctgctc gccgcccgtc cctacgccac ccccgaggcg ctgtacgccg
     5101 cgagcgacgc cgccatggcg gagctgacgg cgcaggacct cgcggaggcg atggccggcc
     5161 acccgcccat cggccgcccg aaacccggcg acccgacctc ggccagggag cagcgcggca
     5221 tggccggcgc ctccgacgca ctcaaggccg agatgctgga gctgaacctc gcctaccagg
     5281 agaagttcgg ccacgtcttc ctgatctgcg ccaccggccg gaccggcgag cagatgcggg
     5341 acgcggtcag ggagcggatc ggcaacacgc cggagcggga gcgggagatc gtccgcaccg
     5401 aactggggaa gatcaaccgc atccgcctgg cccgactcgt cgaagaggac tgacagcagc
     5461 atgagcacct ccgccaccgc gtccgtgtcc acgcacatcc tggacaccag cgccggccgc
     5521 cccgccgagg gcgtcgccgt ccagctctcc gcccgcagcg ggcgcgcggc ccactggcag
     5581 gcgctcggcg gctccgcgac cgacgcggac ggccggtgca aggacctccc ggccctgccg
     5641 gaggggacca cccaggtacg gctcgacttc gcggtggagc cgtacttcga gaagaagcaa
     5701 gccgatgcgc agcaggacgc ccccgcgaat cgggacagcg gcgccggggt gttcttcccg
     5761 gaggtggcga tcacgttcgc cgtcgtaccg ggcgagcact accacgtacc gctgctgctc
     5821 aacccgttcg gctactccgt ataccgaggg agctagctac tcatgcccac cattctggga
     5881 cagaaccagt acggcaaggc cgagaaccga gtcgtcaaga tcacgcggga cggcgccacc
     5941 caccacatca aggacctgaa cgtctccgtg tcgctgagcg gcgacatgga agaggtccac
     6001 tactccggct cgaacgccaa cgtcctgccc accgacacca ccaagaacac ggtgtacgcg
     6061 ttcgccaagg agcacggcat cgagtccgcc gagcagttcg gcatccacct cgcccgtcac
     6121 ttcgtcacca gccaggagcc gatccaccgg gcccggatcc gcatcgagga gtacgcctgg
     6181 gagcggatcg aggcctccga cgccaactcg cggttcatcg gcgccgacga ggtcaagcac
     6241 tccttcgtac gcaagggcca ggagacccgg ctcacccaga tcacctacga cggctcgtcg
     6301 tgggaggtga tctcgggtct gaaggacctc gtcgtgatga actcgaccaa ctccgagttc
     6361 tggggctacg tcaaggacaa gtacacgacg ctgaaggagg cctacgaccg catcctggcc
     6421 acccaggtct ccggccgctg gcggttcaac tggaccgacg acgaccagcg catgcccaag
     6481 tgggagaagt cctacgagca gacgaagaag cacatgctcc aggccttcgc cgagacgtac
     6541 tcgctctcgc tccagcagac gatgtaccag atgggcgcgc ggatcatcga caaccgcagc
     6601 gagatcgacg aggtccgctt ctccctcccg aacaagcacc acttcctggt cgacctggag
     6661 ccgttcgggc tgaagaacga caacgaggtg tactacgccg ccgaccgccc ctacggcctg
     6721 atcgaggcga cgatcctgcg ggacggctgc gaggcgagga tccccgtgga cctgaccaac
     6781 ctctgacgcc cctcccgacg ttccctcttt cggcacccgt ggccggggaa cccttctcct
     6841 cggccacggc actcaaactc ccagggtcct gccgtgcccc ctccaaccca gcgcaaagga
     6901 cgaaccatgg cagcagcccg gcgcatcgtc atcgagaact gtgcgatcgc gaccgtcgac
     6961 gccgacgaca ccgagtacgc ctccgggcac gtcgtcctcg ccggcaaccg catcgagtcg
     7021 gtcggcgcgg gcaaagcccc cgagggcctg gagaacgtcg tacgccgtat cgacgcctcc
     7081 ggtcacctcg tcacccccgg actgatcaac acccaccacc acttctacca gtggatcacc
     7141 cggggtctgg ccacggacca caacctcttc gactggctgg tcgcgctgta tcccgtctgg
     7201 gcccgcatcg acgagccgat ggtgcgcgcg gcggcccggg gctcgctcgc gatgatggcc
     7261 cgcggcggcg tcaccaccgc catggaccac cactacgtct tcccgcaggg ctccggcgac
     7321 ctgtccggcg cgatcatcgg cgccgcccgc gacatgggcg tccgcttcac cctcgcccgc
     7381 ggctccatgg accgcagcga gaaggacggc ggcctgcccc cggacttcgc cgtcgagacc
     7441 ctcgacgggg cgctggccgc caccgaggac accgtccggc ggcaccacga ctcctccttc
     7501 gacgccatga cccaggtcgc cgtcgcgccc tgctcgccct tctccgtctc caccgaactg
     7561 atgcgggacg gcgcccagct cgcccgccgc ctcggcgtac ggctccacac ccacggctcg
     7621 gagaccgtgg aggaggagaa gttctgccac gaactgttcg gcatgggacc gaccgactac
     7681 ttcgagtcca ccggctggct cggcgaggac gtgtggatgg cgcactgcgt ccacatgaac
     7741 gactccgaca tcgccgcctt cgcccgcacg aggaccggcg tcgcgcactg cccgtcgtcc
     7801 aacgcccgcc tcgcggccgg tatcgcccgc gtccccgaca tgctcgcggc cggcgtcccg
     7861 gtcggcctcg gcgtcgacgg caccgcctcc aacgagtccg gcgaactcca caccgagctg
     7921 cgcaacgccc tcctcatcaa ccgactcggc gcgcacaagg aggccgccct gaacgcccgc
     7981 caggcgctgc gcctcggcac gtacggcggc gcccaggtgc tgggccgggc ggcggagacc
     8041 ggctccctgg agccgggcaa gctcgccgac ctggtcctgt ggaagctgga cacgctcgcc
     8101 cacgcctcca tcgccgaccc ggtgaccgcc ctggtcttcg gcgcggcggc cccggtcacc
     8161 gcctccttcg tggacggccg gcagatcgtc gaggacgggc ggctgctcac ggccgacgag
     8221 gacgccatcg cccgctccac gcgggacgag gcccagcggc tggcgaggat cgccgcgcag
     8281 ggctgaacac ccggatgact ccggccggga gggacggctc ccggtcggtg gccgcggacc
     8341 cgagcggggt ccacggcggt cgtctccggg gcgcgcgtac acgcgtgcgc cccggaacgg
     8401 ccacccccgt cccgcacgtc cggtcccgca cgaccacccg caccacctcc ttgacaccca
     8461 cggccgtcat ccggcgcagc cgtgtaaccg accggaggga agccgccgtg gccgaccacc
     8521 ccgttgacga aaaactcccc gcgctcaaga tggcgacgac cggcctccag catgtggccg
     8581 cgatgtacgc gggagtcgtc gccccacccc tgatcgtcgg cgcggccatc ggcctgaccg
     8641 ccaccgacct gaccttcctc accggcgcct gcctgttcac cgcgggcctc gccacgttcc
     8701 tgcagaccat cggcgtctgg aagatcggcg cccggctgcc gttcgtcaac ggcgtcacct
     8761 tcgccggtgt cgccccgatg accgcgatcg tcgcctccac cgaggacaag tccgacgccc
     8821 tgccggtcat cttcggcgcc gtcatcgtcg ccgggctcct cggcttcata gccgcccccg
     8881 tcttctgcaa ggcggtccgc ttcttcccgc cggtggtgac gggcacggtc atcaccctga
     8941 tcggcatctc gttgctcccg gtcgccttcg gctgggcgca gggccccgac ccggcggcgc
     9001 acgactacgg ttcggcgacc aacctcgggc tggccgccgg caccctcgtc gtcgtcctgc
     9061 tgctgcggcg cttcacccgg ggcttcgtca agcagatcgc ggtgctgctc ggcctggtcg
     9121 cgggcacact gatcgcgatc ccgttcggcg ccacggactt cggcccggtc gccgacgccg
     9181 cggtcatcgg cttcccgacc cccttccact tcggcgcccc gcagttccag ctcgccgcga
     9241 tcctctccct gtgcgtggtg atggtggtgt cgatgaccga gtcgaccgcc gacatgctgg
     9301 cgctgggtga gatcgtcgac cgcccggccg acgagaagac catcgcggcc ggcctgcgcg
     9361 ccgacaccct cggctccgcg atcagcccgc tcttcaacgg cttcatgtgc agcgccttcg
     9421 cacagaacat cggcctggtc gcgatgacga agatccgcag ccggtacgtc gtcgcggccg
     9481 gcggcggctt cctggtgctg atgggcctgt gcccgatggc cgcctcgctg atcgccgtcg
     9541 taccgcgccc ggtgctcggc ggggcgggcg tggtcctgtt cggctcggtc gcggccagcg
     9601 gcatccagac cctggtccgg gccggcctgg agaaggacaa caacgtcctg atcgtggccg
     9661 tctccctggc cgtcggcatc atccccatca cggcgccgga gttctaccac gccttcccgg
     9721 agacggcgcg gatcgtcctg gactcgggca tctcgacggg ctgtgtcgcg gcggtcctgc
     9781 tgaacctggt cttcaaccac ctgggcccgc gcgaccggga cgcccacgac gtgacccacc
     9841 cgatggaggc gggcgaggag atcacgggcg tcccccggac cccggcagca ccatgagatc
     9901 ggccagaaca gctcccaact ccgcttaggc ttctgcctcg gtcaactcac cgttgaccgg
     9961 gggacagggg acaggggacg agggggagac ggaccgatga accacgcgtc cgaggtgttc
    10021 cggccgttgc aggcggacga tccgcccacg gtggccggat accgcctggc cgcccggctc
    10081 ggggtgaggt cacggtggcg accgacgtct tcgcgctggg ccagacggcg gcgttcgcgg
    10141 cgctgggccg accgctgtac ggggacggct ccgcggtcgg ggtgctgtac cggatcgtgc
    10201 acgacgaacc cgacctgacc gcgctgcccg agcagctccg tccgttgatg gcccggtgtc
    10261 tggccgccga cccgcgggag cgggcggact tggccgagat cgtcgagtgg tgccggcagc
    10321 ggctgggcgc ggacgccgac gcgggggcgg gcccggccgt ctggcgggac gtcatggggc
    10381 cggaggtgac ggttccctcc ccggcggacc tcgacgccac ccgggtctcc ccggcgaccc
    10441 tcgacccgac gcgggtgcag aggcagccac tggtcgtcac gcggccacag acgcaaccgc
    10501 cggggccgga ggagagacgg gcgcgcagac ggcgtggcgc actgatcacg gccgcggccg
    10561 tgacggcggg ggcgctggtg ctgaccggcc tggcgtggac ggtcgcggac gcgggggaca
    10621 gattccgcga ctgggtggcg ggcgcaccct cgacgcccgg cccggagaag tccggacggt
    10681 cgtccgcgcc ggagtcgtcg acgggggcgc cctcggcatc cgggcctgcg tcgggggcgg
    10741 gtggcgggac accggaagcg tcccgtccga ccccggccgc gaccagcctc cctcatggtg
    10801 gacatgacca tctggaagaa ggcggcctag agtcccaaca cccccggctc cgacgccagc
    10861 ttcctgaagt actcctgggg gcccgggacc agcttgcggg ccttcaggtc cagcaggccg
    10921 ccgaccgccg tgatctcggc cgccaccgtg ccgtcggact tgcggaccgt ctgctcgatg
    10981 cggaacgtct tgccctcgcc ccaggcgaag gcacaggtca cctcgacctc gtcgcccgcg
    11041 agcagctcgc gtttgtagcg gatggtggtc tccagggcga ccgggcccac gccgctgccg
    11101 atgagggcgg actggctgat ccccgcggcc cgcagtaacg accagcgggc gtgttccgcg
    11161 tagttcagat acacgctctg gttgagatga ccctgcacgt cggtctcgta accgcggacg
    11221 gtcaccggga cggaaaacgg ctcgctcatg ggcttccctt ctcgcaccgg acactcgtgg
    11281 cgtacgcaac gatccactga tcttggcatg cccatcacgc tcggcgcggc gaggccagga
    11341 ggtaacgggt cccggtgcgc ggctcgctgt gctcgctcac ctgccagcct gccccctcca
    11401 aggtggccgc gcaggtccgc agcgcctcgc cgtccggctc gtacacggcg acggcctccg
    11461 gctgcggggt ctcccgcacc cggtagcccc cgtcgtcccg cccggccggg cggtgtccgg
    11521 ccgcctccag cgccagtgcg gcggcctgca cgagatgcgt gcgctcccag ccgcacggcc
    11581 gctccacggc accgtccggg ttggtcatcc ggcgcagctc cagcagcccc tgccaggcgc
    11641 tgtgcacctc acggcgccgg gcgggccctg tctcttgcgc cgcctcctcg ccgccgacgc
    11701 tcgcggcgaa cacaccggcg gtggcggggg cctcggccgc gggctcgggc acctgcatga
    11761 cgccctgccg cacccggtgg ccttccggcg tcaggaagtg gtcgtgcggc ggccgggggt
    11821 gccggaaggc gagcccccgc ttcaccagcg ccgcgagctg tgactccgta ccccgcagcc
    11881 ggcctgtcac cggatcggcg gcgtcgatga cccgccgctg cgcggcggtc ggcggtcgcg
    11941 tcacggcgtg ctcctttccg agcccggccg tccggtcccc tcggacggcc cactgcaacg
    12001 ctacgacccg cctctgacat ccgcccctac tgccggtatc cgcccaggaa ccgcccgatg
    12061 cgcccgatcg ccgcctccag gtcatcggcg tggggaaggg tcaggatgcg gaagtgatcg
    12121 ggggccggcc agttgaagcc cgtgccctgc accacctgga tcttctcccg cagcagcagg
    12181 tccaggacga acttctcgtc gtcgtggatc ttgtgcacct tggggtcgag gcgcgggaag
    12241 gcgtacagcg cccccttcgg cttcacgcag gtcacgccgg gaatctcgtt cagcttctcc
    12301 caggccacgt cgcgctgttc gcgcaggcgg ccgcccggca gggtgaggtc gcggatggac
    12361 tgccggccgc cgagcgcggc ctggatggcg tactgggcgg gggcattggc gcacagccgc
    12421 atggaggcca gcatcgtgag gccctccagg tagtccttcg cgtgctgcct cggaccggtg
    12481 accaccagcc agcccgaacg gaagcccgcc acgcggtacg tcttggacag gccgcagaag
    12541 gtgagcacca ccaggtcggg ggcgagcgcg gcggccgagt ggtgcacggc gtcgtcgtag
    12601 aggatctggt cgtagatctc gtcggcgaac accatcaggc cgtgccgccg ggcgaggtcc
    12661 aggatgccct cgacgatctc cttcgggtag accgcgccgg tggggttgtt ggggttgatg
    12721 atgaccacgg ccttcgtgcg gtccgtgatc ttcgacgcca tgtcgtccag gtccgggtac
    12781 cagtccgcct gctcgtcgca gaggtagtgg accgccttgc cgcccgcgag ggtcgtcacg
    12841 gccgtccaga gggggaagtc cggggcgggg atgaggatct cgtcgccgtc ctcgatcagt
    12901 gcctggaccg ccatcgacac cagttcggac acgccgttgc cgaggaagac gtcgtcgacc
    12961 ccgacctcca ggcccagtgt ctggtagcgc tgggcgaccg cgcggcgggc ggggaggatg
    13021 ccgcgcgagt ccgtgtagcc gtgcgcctgc ggcagcatcc ggatcatgtc ctggaggatc
    13081 tcctccggcg cctcgaaccc gaagagcgcg gggttgccgg tgttcaggcg cagcacgctg
    13141 tgaccggcct cctccagcgc gttggcgtgc tctatcaccg ggccgcggat ctcgtaacag
    13201 acctcgctca gtttgctcga ctgccggaac tccatgcgcc gcttcccctc gccgacttgt
    13261 gttgcttggt tttaccaagt agccgcttgg aaagtccaac aacttgtcta gactgcgtcg
    13321 catgccacct cgccgaagct acgaccagta ctgttccgcc gcccgcgccc tcgacgtcgt
    13381 cggcgaccgc tggaccctgc tgatcgtccg ggagctcctc gccggtcccc gccgctacac
    13441 cgacctgcac gcggacctgc ccggtgtcag cacggacgta ctcgcctcgc ggctgaagga
    13501 catggagcgc gacggcctcg cgacccgccg ccggctgccc ccgcccggcg cggccttcgt
    13561 gtacgaactc accacccggg gacgcgagtt gctgcccgtg ctccaggcgc tgggggagtg
    13621 gggccgggcg gaactcgggg accggcggcc gacggacgcg gtacgggcgc actggttcgc
    13681 cctgccgctg ctgcgcctgc tggacgggga ggggctcgtc gaagtccgcc tggaggaggg
    13741 gctgttccat ctgcacgccg gtgccgagga ggggcccgtg tacggcgacg ggcccgcccc
    13801 cggggagccg gacgcccggc tggtcctgga caccggcacg tgcacggcgc tcagccgggg
    13861 ggagctgagc ctggcccggg ccgtgcggga gggccgggtc gaggtgagcg gcgagggcac
    13921 gctggcgaag gcgctccgcg aggcatgaga gaaggcccgt gtgacgcgag ccttctgatg
    13981 gcatatcggg cacttgggcc tcaggaaagg gggttgggca gttccgccca ctggtccccg
    14041 gccgtctgcg gcgagagccg catcagcgtc agcgccttgg tgggcagcgg gtccgcgcgc
    14101 agcgccgcga ggcccggagt gcggggcagc tcccgtacgg ccgtctccag cgccgccgtg
    14161 agcgccgccc ccgaccccgc cgtgccggcc agcgctcccg ccaccagcga gccgaacagc
    14221 ttgcgccgga gcgtgcgttc gtcgtccgtg accatgcggg cgggcaggtc gggcaccgcg
    14281 atgccgtgcc gggcgagacg ggccgggctg acgcggatgt cggccaggtc gcggtagacc
    14341 agccgcagcg gatcgcccgc gggcgacagg atcaccagga ggttctggcc gtgcgcctcc
    14401 agggccacgc ccagctccag cagccgcaga ccgacggtga gggcgaggcg cgcgaagccc
    14461 gccagccagg cgggggagcg gggcagttcg gtggtggcga gcgccgccac gggcaggacc
    14521 cgttcgccgt ccctcgcgta ggcctccggc ggctcccgca gaacggccgc gaagtcgggg
    14581 gagccggccg ccgccgcgcc cagggtgcgg gtcacgtgca gaagcccgtc ggtgtgtgcc
    14641 gccggcgtct cggcgaactc cgacagcacc gcggacgccg cgaccgaggc cagcgagatg
    14701 tcccgcaccg acgacgtcag ccgggcactg agcgaggtct tgacgtgcga ccccccgggc
    14761 agcgccagcg tccgcagcgc catcagggga tgcccggcgc gccgctcctc gcacacccgc
    14821 ttcagcacgt gcgccgcctg ccacgggtgc accggcagca ccacccgccc cccgtcccgc
    14881 agatcccgcg gccacgcgcc cgtcaccagg cactcctccg cccgcaccgg caccagcccc
    14941 agctccacca ccggccggtg ctcgggcccg taggcgagct gctcggccac cgagaaaccg
    15001 ggccgggacc ggcaggtggg gtggaacgga tgcccgtcga cgatccgctg ctcccactcc
    15061 cagtcgtgct ccggccaccc gtccgtgacg cgcccctcct gccccgccct cgacagcgcc
    15121 aacgaggcgc cgctgtgcgc gagttcggcg gcgaaggacg cggagtgcgg tacggcgagg
    15181 tccgtcacca gccgggccgg atcgtcgtac tccgcctcgt cgagccgcag gacggtgacg
    15241 tacgcgccgg tcgcgtacgg atccggccgc gggccgtgca gccggcggcc gtcggacagg
    15301 tgcagcgtca gcccgtcccc gccctgctca cggcgggtga cccagggcag cggatcgtgg
    15361 gcgagaccgc gccacagacg ggacagcacg gccgcccggg caccgggcac ttccgcctcg
    15421 taccgcggca ggagaccggg ccgtacgacg gccagttcgt cggcgacctc ggcctcggcg
    15481 gtgggggaac ggtgcacggg cgggctcctc gggtacgaat agggcgtcac ggcgggatga
    15541 cgacggcacg catactgatc atctccgccc ggaagtccgg aaatccttca aggaccgcag
    15601 ggaacgagtg gaagcgtgga cctcatgccc ccgcccgacg gcgacgactc cgcccacggt
    15661 gactgtgccc atggtgactc cgcacacggt gtctccgccc aggacgaccc ggtcaccgac
    15721 ggcctcgccg aacgggccga cgcgtacgcc gccgtgccgc tgctgaactg cctgctgcgg
    15781 gaggtggcgc ggccggtgag cgagacgggc gagcaccggg tgcaccacct gcccggcggg
    15841 gaccgcctgc tgcgtgtgcg cggcacgcgg cggcccgccc agccggaggt ccgtgtagcc
    15901 ggcggctggc accgggtcgg ccacaccgag ctggtcaaac tcgtcgccga ggaactgcgc
    15961 cggcacaccg ggctgtccaa ccacgaactg cccgccgaga tgatcgacag ccgggacgcc
    16021 gtggccgcgc tgctggccgc ccgcgcacgg gccaccccgc ccgacgaccc ctatctgcgc
    16081 tccgagcagt gcctcctcac cggccacacc caccacccgg cccccaaggc acgcggcggc
    16141 ggccccgccg ccggctggct gccgtacgcg cccgaggcgt acgcccgttt cccgctgacc
    16201 ctgctcgggc tgcgcgagga caccgtcgtc gaggagggcg acacctcgcc cctcgacgcc
    16261 ctcggtacgg ccccgcccgg ctaccggctg ctgcccgccc acccctggca gctcgacctg
    16321 gccggtccgg agctcgccga cgccttcgcg gacggcagac tcgtccggct cggcacgacc
    16381 gccttcggca cctggccgac ggccgccatc cgcacgctct acgcgcccgg gcccgacctc
    16441 ttcctgaagt tcagcctgga cgtacgcatc accaacgaca tccgccggct gtggcgtcac
    16501 gacctgctcg ccctgcgccg gaccgacgcg gccgtgcgcg ccgccttcga gacgttcgaa
    16561 ggccccccgg cctggctcag cgaccgggga taccgcaccg ccgacttcgc cttcgaggcc
    16621 ctggccgtcc tcgtccggga cggcttcgga ggccgtctcc tgcccggtgc gaccccgctg
    16681 ctcgccgccg gtctcgtcga gggcttcgac ggcagcccgc tcgaccgggc cgccgacccc
    16741 ggggcgtggt ggtccgcgta cctggcgcag gtggtgcccc cggccatgac tgccttcgcc
    16801 cgccatggtg tcgtcatcga ggcgcacctc cagaacaccc tggtcgccgt ggacgccgaa
    16861 ggcacacccg tgcaggcgct gtaccgggac gccgagggcg tgaaactcct gccggacgtg
    16921 gagcgggaag ccggctggga gcggctcgtg tactgcctgg tcgtcaacca cctcggcgag
    16981 atcgccggcg ccctcgcgga acgccacccc ggcctcgacc cctggcccgc cgcccgccgc
    17041 gaactcgccc gccacgacgt ccctgagatt cccgccctgc tcgcctcacc caccctcccc
    17101 ggcaagacga acctgctgct ccgctggacg ggcgcggacg gcgcggacgc gcgctacctg
    17161 ccgctgccca acccgctgcg cggcgcctga gggcagttca cgccgtcgcc gtcgggctcg
    17221 gctcgtgcgc ggacggggcc tcgtcgtcca tgtccccgcg cagggcggcg atgacgaagg
    17281 ccgtcatgga ggccaggccg agcagcgcga gcggtcccca gatcgccggg accgcccaga
    17341 acggccagcc gttggcggac tgcgcccaca gggtgaagag ggccgcgacg cccatgcaga
    17401 cgccgtgcca ccgcaccacg cctcctgccg tcgcgtgccg ccggtcaccc cgcgcgaaca
    17461 gcggccacgc cccgccgacc agggcggaca gaccgaacgc gaaacaggcg agcgcaccgc
    17521 cgaggcggtc ctcggaccag cccacgggcc cgtgggacgt ctgctgccgc cgcccgtcgg
    17581 cgtcccgtac cccgacgacc tgcccgtgcc agatcaggcc gacgaccctc tcgcccggct
    17641 ccagctccga cacgaccgga tcggtctgcc ggaacgtcac gtaccagggc ttgccggagg
    17701 gcagcagcag ctccgcctcc ggcgagccgt tccgccgccc gcggttcagg tcggccttcc
    17761 ggacggtgaa ctcctgctcc caccggcacc ccgacgcctt cacggggacg gaggcacagg
    17821 ccggcgcggc acggaactcc cgctcccggt ccagcgcccc gcggacctcc agcgtcatgg
    17881 ccactccgac gacgagcgtc gcgacaccca tcaggagcca cgtcacgttc cccggccctt
    17941 gccatccgcc cgaccccatc gtgccccccg cctcgccgga ttccgcccga acggtatccg
    18001 aacctgtcgg gaccgagccc ctggcagacg gcgcccgggc gggtcatgac cggtccggca
    18061 cacgagcacg gggagccggg cgggcagccg ggaccgggcg cgatggcgta cccgagcaca
    18121 ggcgcgctgg tcagcgccca gtagagtgcg cctctgttgc ccccgaaccc cgaggtaccg
    18181 cgcagtgacc cccgcacctg acgcaccgac cgccgccgtg accgtcgtcg ggctcggggc
    18241 cgacggctgg gccggactgc ccgacgcctc ccgcaccgcg ctgcgcgagg ccgaggtcgt
    18301 gatcggcgga ccccggcagc tggacctgct gcccccggag tgcaccgggc agcgcctcgc
    18361 ctggccctcg ccgctgcgcc ccgccgtccc cggcctgctc gccgcgcacg ccgggcgccg
    18421 gatcgccgta ctggccagcg gggaccccat gttctacggc atcggccgcg ccctcgccga
    18481 ggagaccggc gccctgcgcg tcctgccgca cccctcctcc gtctcctacg ccgccgcccg
    18541 gctcggctgg ccgctggagg acgtggaggt cgtcacgctc gtcggccggc ccgccgcccg
    18601 cctggccgcc gccctgcacg acggccggcg gctgctcgtc ctcagcgcgg acgccaccac
    18661 tcccggcgag gtcgccgccc tgctgcgcga ccggggcttc gggcccagcc ggatgcgcgt
    18721 cctcgaacag ctcggcggcg acagggaacg cacgaccgac gaggccaccg ccgacgactg
    18781 gcccgggggc cggcagcccg gtgatccgct gaacatcgtc gccgtggagt gccgccgcgc
    18841 cccggacgcc ctgcggctcg gcgccgtgcc cgggctcccg gacgaggcct atgagcacga
    18901 cgggcagctc accaaacggc acatccgcgc ggccacgctc ggtgtgctcg cccccgcgcc
    18961 cggcgaactg ctgtgggaca tcggcggcgg ctccggctcg atcgccgtcg agtggatgcg
    19021 cacccacccc tcgtgccgcg cggtcaccgt ggagcgggac ccggcgcgcg ccgagcggat
    19081 cacccgcaac gccgaccggc tcggcgtgcc cggactgcgc gtcgtcaccg gcgccgcgcc
    19141 cgccgtcctc gccgaactcc cgccacccca cgccgtgttc atcggcggcg gtctcaccgc
    19201 gcccggcctc ctcgacgcgt gctgggaggc gctgcccggc ggcgggcggc tggtcgccaa
    19261 caccgtgacg ctggagtccg aggcgctgct cgccgacgcc caccggcgcc acggcggcga
    19321 actggtgcgg ctcgccgtgg cacatgccgt gccggtggga ggcttcaccg ggtggcggca
    19381 ggcgatgccg gtgacccagt gggccgtacg gaaaacgccc gacacctctt caggaccttc
    19441 ttcaggagca gacagatgac cgtgtacttc atcggtgccg gccccggcgc cgccgacctg
    19501 atcacggtgc gcggcgcccg cacgctcgcc gcctgccggg tctgtctgta cgcgggcagc
    19561 ctggtcccgc gggaactgct cgccgaatgc ccgccggacg cccggctggt ggacaccgcg
    19621 cagctcgacc tggaccagat caccgccgag ctgctgcgcg cccacgagga ggggcacgac
    19681 gtggcccggc tgcactccgg ggaccccgcc gtgttcagcg cggtcgccga gcagatgcgg
    19741 cggctggacg cggccggggt gccctacgag gtcgtcccgg gcgtccccgc cttcgccgcc
    19801 gcggccgctt ccctgaagcg ggaactgacc gtaccgaccg tcggccagac cgtgatcctc
    19861 acccgcgtcg ccaaccgggc caccgccatg cccgagggcg aggacctggc caccctcggc
    19921 cgcagcggcg cgctgatcgt gctgcacctg gccgccaagt acgtggaccg cgtggtggag
    19981 gaactcctcc cgcactacgg cgccgactgc cccgccgcgg tcgtcgccta cgcctcccgc
    20041 ccggacgagc tgatcatccg cggcaccctc gacgagatcg gggggaagac gaaggaggcc
    20101 ggtgtgctgc gcacggccgt gatcatggtg gggcggacgc tcggggcgga acagttccgg
    20161 gacagccacc tgtactcgcc ggagcgggaa cgccacgtgt gctgacagcg gtgaacgtgt
    20221 acggcccgcg ccgtcaggcc ggcgcgctgc gcccgaccac cgtccccgcc cggtcgatgc
    20281 agatcacgtc gaccacgacc ggcgccccgc gcagcacggt cagggcctcg tcgcgggcgg
    20341 tcgtggcgac caggtcgccg agcggcaccc cggcggccag gcacgactgg agcgcggcga
    20401 gcccggtgtt ggcatccgcc acctgtgcgg ccagcacctc gtccgcgccg ccgcgccgag
    20461 ccagctcggc gaggaagccc ttgtcgacct gggaacgggc cgagtgcagg tcgaggtgcc
    20521 cggcggcgag cttggagagc ttggcgaaac cgccgcagat cgtcaggcgt tcgacggggt
    20581 ggcggcggat gtacttcagc acggcgcccg cgaagtcgcc catgtcgagc agcgcgtcct
    20641 cgggcagccc gtactcggcc acgaccgtct tctccgacgt cgacccggtg cacccggcga
    20701 catgggtacg ccccgccgcc cgcgcgacgt ccacgccccg ccggatggag tcgatccacg
    20761 ccgagcagga gtacgggacg acgatgccgg tcgtgcccag gatggacagg ccgcccagga
    20821 tgccgagccg ggggttccag gtggagcggg cgatctcctc gccgtggtcg acggagacgg
    20881 tgatctcgac gtcgcccggg ccgccgtgcc gggcggcgac ctcggcgacg tggtcgcgca
    20941 tcatctggcg ggggaccgga ttgacggccg gttcgccgac gggcaggggc aggcccgggc
    21001 gggtgacggt gccgaccccg gggcctgcct tgaacacgac cccggttccg gcgggcagcc
    21061 gccgtaccgt gacccggacc agcgcgccgt gcgtgacgtc cgggtcgtct ccggcgtcct
    21121 tcacgacccc cgccatcgcg tgcccgtcgc ccagctcctc gacggccagc gcgaacgacg
    21181 gcgtctgccc cttcggcagg gtgatcgtca cggggtcggg aaactcgccg gtcagcaggg
    21241 cggtgtacgc cgccgtcgtg gccgccgtcg cacaggcgcc ggtggtccag ccgggccgca
    21301 ggccggtgtg ctccagctgg gccctgcggc cgcccttcac ttcgctgctc atgaacggac
    21361 ctggacttcc atgcgcgtac tgattctcgg cggcaccacg gaagcccgcc gtcttgccga
    21421 actgctccac gacacgcccg gcctgacctt gaccagttcc ctcgccgggc gggtggccag
    21481 cccccgcctg ccgccggggg aggtccggat cggcggtttc ggcggggcgg aggggctggc
    21541 cgcgtggctg cgcgagcacc gggtggacgt gctcatcgac gccacccacc ctttcgccgg
    21601 gacgatcagt ttccacgcgg cgcgggccgc cgccaccgcc catgttcccc tgctcgccct
    21661 gcggcgcccc ggctgggtcc ccgtcgaggg cgacgactgg cacgacgccg gctccctcga
    21721 agaggccgcg aggctgctgc ccgcgctcgg caggcgcgtg ttcctcacga ccggccgtat
    21781 gggcctggcc gcgttcgccg ggctggacga cctgtggttc ctcgtccggt ccgtggacgc
    21841 gcccgaggcc ccgcacccgg cccgcatgga ggtgctgctc gaccgaggcc ccttcacact
    21901 cgacggcgag cgcgaactgc tgcgccggca ccgcgtcgac gtcgtggtga ccaaggacag
    21961 cgggggagcg gccaccgcac cgaaactcac ggcggcccgg gaggccggcc tgccggtcct
    22021 cgtgatccgc cgccccccgg tccccgaggg cgtcccggtc gtgaccggtc ctgaggaagc
    22081 ggcccggtgg gtcggcgagt ggttccaggg gcgcgggttg ccggccggcg gctgagaacc
    22141 ggcgtggtcc ggggccgggc cggccgcggt cgtccgctgc gcggccctgc ctcccgccgc
    22201 gtccctgccc agggctgtcc ggccgcggtt gcccggtacg cggtctcgcc tcgcgccggg
    22261 tccgtgaccg gccccgttct gcgagccggc ggcgagcccg ccgccgcgcc ccctcacgcc
    22321 tccggatagc gccgcggagt ccacacgatc tcctcgccgt ccccgcgccg tacggcccgg
    22381 gtctgggagg agccgaccag caggatcgtg cgcatgtcga cctcggccgg gtccagatcg
    22441 gccagccgta cgatccggac gcgttcgccg gtgccgccca cgtcccgggc caccacgacc
    22501 ggggtgtccg gcgcccggtg ctccagcagc agctcgcgtg ccttgcccac ctgccaggtg
    22561 cggctgcggg agccggggtt gtacagggcg aggaccaggt ccgccgaggc cgccgcgtgc
    22621 agccgttcgg cgatgacctc ccagggcttg agccggtcgg agagcgagat ggtggcgtag
    22681 tcgtggccga gcggggcgcc cgcgcgggcc gctgccgcgt tggcggcggt cacgcccggc
    22741 agcacccgca ccgggacgtc cgcgtactcc tcgtgggacg cggcctccag gacggccgtc
    22801 gccatggcga agacgcccgg gtcgccgccg gagacgaccg cgacccgccg cccgcgccgg
    22861 gccaggtcga gggcgaactc ggcgcgctcc gactcgaccc ggttgtccga gccgtgccgg
    22921 acctgcccgg gccgccgcgg cacccggtcg aggtaggtcg tgtagccgat caggtcgtcg
    22981 gcggcggcga gcgcaccccg ggtctcgggc gtcagccaca gcggaccggc cggcccggtc
    23041 ccgaccacga cgacctcgcc ccgctcccgg gcctgaggcc gctcggtgtc cacctggctc
    23101 ggcagcacgg ccaccgagaa gtagggcacc gactccgcgt ccacctcggc cagttcggcg
    23161 agccgctccc cggccatcgt tgcccgctcg acgtaccggg cgtcgcccag ccgtcccgaa
    23221 gcctccagcg cgccgcgcac cttggtgaag gtccgcccca gtttcatcac cacggccgcg
    23281 tcggtcgagg cgagccgtgc ggtcagctcc tcctcgggca gggtgcccgg gaggatcgtc
    23341 agcacctcct cgccctcggc gagcggcgtg cccagccgcg cggcggcggc ggagacggac
    23401 gtgacgccgg ggatcacctc ggtgtcgtag cggtgggcca gccgcttgtg catgtgcatg
    23461 taggagccgt agaagagcgg atccccctcg gcgaggaccg cgaccgtccg ccccgcgtcc
    23521 aggtgcgcgg cgagccgggc cgacgcctcg gcgtagaact cctccatcgc accctggtag
    23581 ccgccgggat ggtcggtggt ctcggtcgtg accgggtaga ccagccgctc ctcgatgtgg
    23641 tcggcgcgga tgtgcttcgc cgcgatcgag cgggcgatgg aacggccgtg ccgggcgctg
    23701 tggtacgcga tcacgtccgc ctcggcgatg acctccacgg cccgtacggt catcagggac
    23761 gggtcaccgg ggccgagccc gaccccgtac agccgccccg ttgtggactg cttgccgctc
    23821 actcttcctc actcgcgatc gcgttgagcg cggcggcggc gatggcgctg cccccgcgac
    23881 ggccgcgcac gaccaggtgc tccaggccgg acggatgcgc ggccagggcg tccttggact
    23941 cggcggcccc gacgaagccg accggcacac cgatcacggc ggccgggcgc ggagccccct
    24001 cctcgatcat ctccagcagc cggaacagcg cggtcggcgc gttgccgacg gccaccaccg
    24061 agccctccag ccggtcccgc cacagctcca tcgcggcggc gctgcgcgtg gtgcccagct
    24121 tcgcggccag ctccggcacg gacgggtcgg agagcgtgca gagcacgtcg ttgccggccg
    24181 gcagccgctt gcgcgtcacc ccgctggcca ccatctgcac atcggtgaag atgggcgcgc
    24241 ccgcgcgcag ggccgcacgg gcccgggcca ccacggccgg cgtgtaggcc aggtcccgta
    24301 cgaggtcgac catcccgcag gcgtggatca tccggaccgc gacctggctg acgtcggcgg
    24361 gcagggccgc gaggtccgcc tccgcgcgga tggtggcgaa ggactggcgg tagatggccg
    24421 cgccgtcctt ctcgtagtcg tacgtggtca cggtggtctt ctcgctgctc tcggtcgtcg
    24481 taggggtggt catgaggtga tctccgccag ggcggcggcg agtcgggcgg ggtcgttcat
    24541 cgtgctggtc cggggctcct cgccgcgtac ggcggtggag agccggtagc cgccgtccgg
    24601 agcggcgacc acgtccacgc ggtcgccccg ggggtgcccg cagcggcgtt cgcagccgga
    24661 ccagtacagg ggcaggccgt gcggggcgat cgcgccgagg gttccggccg cgtcggtccg
    24721 tacgtccgcc tgcgacttgg cgcatcccgg cctgccgacg caggcgccga cgcgcagcca
    24781 gggggagccc gggtcggtga cgaggccggt ggcggcgagg cgggcgaggg actcgtcggc
    24841 gcgggtccgc ggtgtgggaa gaaccacacc gcgccacggc gtcagacgca gctcaccggc
    24901 ggcgacatgc gtcagttccc gccattggcg caccgagagc cggcccagcg gtacgtgcac
    24961 ggagaggccg tcaccgacga ctcccggggg cggtccgtcc gcgcggccgg tctcccggcc
    25021 ccgccgctcg tggcggatgc cctcggcggt caggcgccgg ccgaccgcat cgagcaactc
    25081 gccgtcagca agggcgagtt cctccacgcg ccagacctgt gccccgctcg cccgggccgc
    25141 ctccaggaag gtctccgcgg ccagcagcgc ggcccgcgcc gcctccccgg cggtgacgtg
    25201 cagcgcatcg ccggccgctc cgaggccgag ccgcgcaccg ccgtccgccg tcgcccgtac
    25261 cgtcacatcg gcaccgagac cggccacgtc cccgcgtccg tcgtcgagcg cgaacaggaa
    25321 acgccccgag agggcctgtg ccgcctcgct cgcgcacagc gccgcgtcga gggccgtcag
    25381 ccaggggcgt acgtccagcg cgccccgccc gtcgagaccg gacagcggcg aggccacgat
    25441 gttgcgcacc cgctcgtgcc cgcgcgaggg cagcagcccg gcggcgtcca gcagcccggc
    25501 caactccccg gcgcagccgc cgtccagacc ccggagctgc acgttgccgc gcgaggtcag
    25561 atgcaggtca ccgtcgccca gccgctccgc cacgtcggcg agcgcccgcg cctgccgcac
    25621 ggtcaggacc ccgccgggga cccggacacg ggccagcgcg ccgtcgtccg ccgcgtgcag
    25681 ccgcagcgtc cccgggcatg cgtcaccgcg gtcccgggag accgctgtgg cctggggcga
    25741 tgaacggagg gcaggcgtgg acatggcggc gagcatacct accatcacac ccggtgtatg
    25801 ccccgccctt ttcccccgac ccttactatg ctcctcggtg gatcatccgg tccgccgacg
    25861 ccacgacggc gacaggggag gaagcccggt gcgagtccgg cgcggtcccg ccactgtgag
    25921 cccggcccac acgggccggg cgagccagga actcccgccg tcccaccacc cgcccggggc
    25981 gcggacaccc cgaggaaggc cagccgccgc atgctgcact catccgggga acgactcccg
    26041 aacccccgca tcctgctcct gtcgacctcc gacaccgacc tgctcagcgc ccgcgcggcc
    26101 gccggcccgg tcccgtaccg cttcgccaac ccctcccgcc tcgccctcga cgacctcccc
    26161 gcgctcctcg acggcgtcgg cctggtcgtc gtacgcctcc tcggcggcat ccgggcctgg
    26221 caggacggac tcgacctgct cctcgccgac ggccgcccgg tcgtcgtcct caccggcgaa
    26281 caggcccccg acgcccagct gatggcgtcc tccacggtcc ccatcggcat cgccgccgag
    26341 gcacacgcct acctcgcgca cggcggcccg gccaacctgg agcagctcgc ccgcttcctc
    26401 tccgacacgg tcctgctcac cggccacggc ttcgaggccc cggaagccgc ccccacctgg
    26461 ggcccgctgc cccgggaggg ccgggacacc gacggcccga ccgtcgccgt gctctactac
    26521 cgggcccacc acatgagcgg caacaccgcc ttcgccggcg ccctgtgcga cgcgatcgag
    26581 gacgcgggcg gccggcccct gcccctgtac gtggcctccc tgcgcgcccc cgagcccgag
    26641 ctgatcgagg aactccgcgc cgccgacgcc atcgtcacca ccgtcctcgc cgccggcggc
    26701 accaagcccg ccgaagcgtc ggccggcggc gacgacgagt cctgggacgc gggcgcgctc
    26761 acggccctcg acgtaccgat cctccaggcc ctgtgcctca ccggctcacg gaccgactgg
    26821 gcggacaacg acgagggcgt ctccccgctc gacgcggcca gccagatcgc cgtccccgag
    26881 ttcgacggcc gcctcatcac cgtcccgttc tccttcaagg agatcgacgc cgacggcctc
    26941 ccggcctacg tcgccgaccc cgagcgcgcc gcccgggtcg ccggaatcgc cgtacgccac
    27001 gcccggctcc gccacatccg gcccgccgac aagcgcctcg cgctggtcct ctccgcctac
    27061 ccgaccaagc actcccgcat cggcaacgcg gtcggcctgg acacccccgc cagcgccatc
    27121 gccctgctgc gccggctccg cgacgagggc tacgacttcg gaacggacgc ggaggtgccc
    27181 ggcctggcct ccggtgacgg ggacgagctg atccgcgcgc tgatcgaggc gggcggccac
    27241 gaccaggact ggctcaccga ggagcaactg gcccgcaacc cggtgcggat cccggcggcc
    27301 gactaccgcc gctggttcgc cacgctcccc ggggaactgc gcacggcggt ggaggagcac
    27361 tggggcccgg cccccggcga gatgttcgtc gaccgcagcc gtgacccgga gggcgacatc
    27421 gtcctcgcgg ccctgcgctt cggcaacctg ctgatcctca tccagccccc gcgcggcttc
    27481 ggcgagaacc cgatcgcgat ctaccacgac ccggacctgc cgccctccca ccactacctg
    27541 gccgcctacc gctggatcgc cgcccggacc gaggacggcg gcttcggcgc cgacgcgatg
    27601 atccacctcg gcaagcacgg caacctggag tggctgcccg gcaagaacgc cggcctgtcc
    27661 gccgcctgcg gccccgacgc cgccctcggc gacctccccc tgatctaccc gttcctggtc
    27721 aacgaccccg gcgagggcac ccaggccaag cgccgcgtcc acgccaccct cgtcgaccac
    27781 ctcgtcccgc ccatggcccg cgccgactcc tacggcgaca tcgcgcgcct ggagcaactc
    27841 ctcgacgagt acgcccagat ctcctccatg gaccccgcca agctcccggc gatccgcgcc
    27901 cagatctgga ccctcatcca ggccgcccgg ctcgaccacg acctcggcct ggaggaccgc
    27961 ccggacgacg acggcttcga cgacttcctc ctgcacgtcg acggctggct ctgcgaggtc
    28021 aaggacgccc agatccgcga cggcctgcac gtcctcggca atccgcccca gggcgcggac
    28081 cgcgtcaacc tcgtcctcgc catcctccgc gcccgccaga tctggggcgg cgccacggcc
    28141 ctgcccggcc tgcgcgaggc gctcggcctg gacgagtccg ccgcgacccg cacgaccgcc
    28201 gacgaggccg aggagcaggc ccgcgccctg gtccaggcca tggaggacgc gggctgggac
    28261 ccggccgcgg tccccaccga acacggtgaa caggtcgccg ccatccttcg gttcgcggcc
    28321 cgcgaggtcg tgccccgcct cgccgcgacc accgccgagg tcgaccacac cgtgcacgcg
    28381 ctggcgggcg gcttcgtccc ggcgggcccc tcggggtcac ccctgcgggg cctggtcaac
    28441 gtcctcccga cgggccgcaa cttctactcg gtcgacccca aggcggtccc ctcccgcctc
    28501 gcctgggaga ccggccaggc gctcgccgac tccctcctgg agcgctaccg cgccgacaac
    28561 ggcgactggc ccacctccgt cggcctctcc ctgtggggta ccagcgccat gcgcacggcg
    28621 ggcgacgacg tggcggaagc cctcgccctg ctcggcatcc gccccgtctg ggacgacgcc
    28681 tcccgccggg tgacgggcct ggagcccgtc ccgtacgagg agctgggccg cccccgtatc
    28741 gacgtcaccc tccgcatctc gggcttcttc cgggacgcct tcccgcacac catcggcctg
    28801 ctggacgacg ccgtacgcct ggccgcctcg ctggacgagc cggccgaggc caaccacgta
    28861 cgggcccacg tccaggcgga cgtggcgtcc cacggcgacg aacgccgcgc caccacgcgc
    28921 atcttcggct cgcgccccgg cacctacggc gccggcctgc tccagctcat cgactcccgc
    28981 gactggcgca ccgacgccga cctcgccgag gtctacacgg tctggggcgg ctacgcctac
    29041 ggccgtgaac tcgacggccg cccggcccgc gaggagatgg agaccgcgta caagcgcatc
    29101 gaggtcgccg cgaagaacac ggacacgcgc gagcacgaca tcgccgactc cgacgactac
    29161 ttccagtacc acggcggcat ggtggcgacg gtccgggcgc tgcgcggcac ggctcccgag
    29221 gcgtacatcg gcgactccac gcgccccgag acggtccgca cccgcaccct cgtcgaggag
    29281 acctcccggg tcttccgggc ccgcgtggtc aaccccaagt ggatcgaggc gatgcgccgc
    29341 cacggctaca agggcgcctt cgaactcgcc gccaccgtcg actacctctt cggctacgac
    29401 gccaccaccg gcgtgatcgc cgactggatg tacgacaagc tcaccgagac ctacgtcctg
    29461 gacccggcca accgcgagtt cctccaggag gccaacccct gggccctgca cggcatcgcc
    29521 gaacgcctgc tggaggcgga gtcccgcggc atgtgggaga agccggaccc ggccgtgctg
    29581 gagggtctgc ggcaggtgta cctggagacg gagggggacc tggaaggcga cgggtgatcg
    29641 ttccgcaccg tcacccggcg gggtgcgcag gcctcaggac catgagcgag ccttccaagg
    29701 ccgccaccat ggcgaaaggg aaccggtcga cctcgagaca gagtgcgacg tcatcggaat
    29761 ggactccttg acgcaccccc tgcgccaact cggcggcggc acgcgacgcg gcggcgcggc
    29821 ggacgaaccc ggcggcgtcc gtcgcgtcct ccgtggtcct gcgagcgatg tactgagcac
    29881 acgccagatc ctcgtcggcc tgcccgtctt cgccggtgac cacgaacgtg acgccgtcgc
    29941 tctcgcgcgt ccgcaggacc cgggccgtcg cctccgccac cacgaagccg gcgcacagca
    30001 ccagcgacgc ctccttgacc gcgagggcgc cgaccgtgcc tgccgtggtc ttctgcacga
    30061 cggtccgtcc gccgaggtcg gcagaccgca gcagtcccgg cgagttgacc aggtcgaacc
    30121 cgggcgcggg cggaccgtcc ttgagcgccg cccagtccgg gtggcgagcc ttgagggcca
    30181 gggcatcgtc cagcgactca gcgagaacga tcttctccgc tccctggccg aacgcccaag
    30241 ccgccacggt gaaagcacgc atcacgtcga ccacgaccgc caccgacggg gcttcgacga
    30301 gctctggtat gccaaggaaa cgagtgtccg taccgatcat gatcgcggat gcccgttcag
    30361 ccgtccttgc cccggtcgaa ccacatcgtc gccaccgtcg gcagcagacc ggcccagaac
    30421 agcacctgcg ggaccgtgcg ttccgtccac gggatctggg tgatcagcag ggcgcagacc
    30481 atggcccacg ccgcctgggc cagggcgaca cggggccagg tgcgtcggtg gagcagcgag
    30541 cgcagattga cctggacgcc ggcgcgcagc ctccggtacc tcagcagggc gcccagggcc
    30601 cagaccacgg ccatggggac gaggtcccag agccgctggc ccagcggcag cggcagctcc
    30661 cgctgggtct cgccctcggt cgcgaacagg tcgatgccca caccggcgag agccaggcag
    30721 agcagggccg gccagcggat gccgcgcagc agacggtagg aggcgtcgtc caggccgctg
    30781 cgcatcgggg cggagtccgg ggcggtggcc agcgcgtcgg cgtacagggt cgcggcctcc
    30841 gccgccttga cgccgggagc ggtcgccgcc ttcttcgtcc gccgggccag tgcctgctcg
    30901 tgctgcgggt cgagccggag gatggcctcg tccaattggc cggcgacggt ccggttgccc
    30961 gccatgtcgg cgatcagcca cgccacctcg taggcgaaca cctcctccgg gcccaacctc
    31021 atggcctcct gggcgagttc gccggcctcc cgcagggcgg cgtcctggtc ctcgcgccgg
    31081 acctggccgc cgttggcccg cccggagcgg atcgccctga tgcgccagag ccagttggcg
    31141 agcagcgcgt agccgtacca gttctcgggg gcgaggcgga tcacctcgcg
//
