LOCUS       NZ_CP023694            11440 bp    DNA     linear   CON 13-JUL-2024
DEFINITION  Streptomyces coeruleorubidus strain ATCC 13740 chromosome, complete
            genome.
ACCESSION   NZ_CP023694
VERSION     NZ_CP023694.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces coeruleorubidus
  ORGANISM  Streptomyces coeruleorubidus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 9335698)
  AUTHORS   Lee,N. and Cho,B.-K.
  TITLE     Direct Submission
  JOURNAL   Submitted (27-SEP-2017) Biological Science, KAIST, 291 Daehak-ro,
            Daejeon 34141, South Korea
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 2.3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 50X
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_008705135.1-RS_2024_04_23
            Annotation Date                   :: 04/23/2024 03:16:00
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,499
            CDSs (total)                      :: 8,405
            Genes (coding)                    :: 8,179
            CDSs (with protein)               :: 8,179
            Genes (RNA)                       :: 94
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 73
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 229
            CDSs (without protein)            :: 226
            Pseudo Genes (ambiguous residues) :: 0 of 229
            Pseudo Genes (frameshifted)       :: 96 of 229
            Pseudo Genes (incomplete)         :: 175 of 229
            Pseudo Genes (internal stop)      :: 12 of 229
            Pseudo Genes (multiple problems)  :: 53 of 229
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 14:54:21
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7218427
            Orig. end                         :: 7229867
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP023694.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria available from Korean Collection for Type Cultures.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..11440
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="27"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11440
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11440
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6440](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..6440)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            430..1896
                     /db_xref="GeneID:91420933"
                     /locus_tag="CP976_RS33320"
                     /old_locus_tag="CP976_33330"
     CDS             430..1896
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91420933"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017: aldehyde dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010034047.1"
                     /locus_tag="CP976_RS33320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_33330"
                     /product="aldehyde dehydrogenase family protein"
                     /protein_id="WP_150483634.1"
                     /sec_met_domain="Aldedh (E-value: 2.3e-172, bitscore:
                     572.6, seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGELYIDGEWTQAAAGGRREVVNPYDASVVTTVDEADATDVDRAV
                     RAARRAFDEEDWANATSRHRADLLLRVRDLLLRDQEDIARTETLDTGKTLAEARIDVED
                     VANAFRYYAELAGKDGGRVVDVGPDVLSRVVYQPVGVCALIAPWNYPLLQASWKVAPAL
                     AAGNTFVLKPSETTPLTTIAMIRLIEEAGAPPGVANLVLGSGATVGAALISHPEVDLVS
                     FTGGLTTGRSIMAGAAEGPRNIALELGGKNPNIVFADADFDAAVDYALDAAFLHSGQVC
                     SAGSRLLVQDSLHDGFVEALARRAQAIRLGNGMAEGTESGPLSSAEHREKVERYIAIAQ
                     EEGARLVTGGTRPDDPALSRGFFLLPTIFADCDRSMRIVQEEVFGPVVTVERFGTEDEA
                     VELANDTRYGLAGGVWTSDASRAQRVAQRLRHGTVWINDFHPYVPQAEWGGFGRSGVGR
                     ELGPTGLREYQEAKHIYQNLAPAPSGWFKG"
     gene            1921..3501
                     /db_xref="GeneID:91420934"
                     /locus_tag="CP976_RS33325"
                     /old_locus_tag="CP976_33335"
     CDS             1921..3501
                     /GO_function="GO:0016614 - oxidoreductase activity, acting
                     on CH-OH group of donors [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91420934"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010034049.1"
                     /locus_tag="CP976_RS33325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_33335"
                     /product="GMC oxidoreductase"
                     /protein_id="WP_150483635.1"
                     /transl_table=11
                     /translation="MAPTTAHGAESAYDYVIVGGGTAGCVLAARLSEDPDCRVCVVEGG
                     PSDVGDERILRLRNWINLLGSEFDYGYTTVEQPRGNSHILHSRARVLGGCSSHNTLISF
                     LPLPQDLDDWVNGGCTGWDPATILPYRDRLLTRIVPVAEADRNPIAKDFVTAASRALGV
                     PVVDDFNAEPFADGTGFFSLAYQPEGNLRSSASVAYLHPVLDRPNLTLLLETWAHRLLP
                     DESGRLTRVAVRGADGEPGTVRAERELLLCAGAIDTPRLLMLSGLGPADDLRGLGIDVR
                     ADLPGVGENLLDHPESVIVWETEGPLPPNSAMDSDAGLFLRRDQGQPRPDLMFHFYQVP
                     FTVNTERLGYPVPPYGVCMTPNVPRARSTGRMWLRSSDPAEHPALDFRYFTDPEGHDER
                     TIVEGLKVAREVAATAPLRDWLVREVAPGPDVVSDADLSEYGRRAAHTVYHPAGTCRMG
                     APDDPMAVCDAELRLLGVEGVRIVDASVFPTMPTINPMVTVLLAAERAADLISDRPGPT
                     EQSKQEARQ"
     gene            3498..4985
                     /db_xref="GeneID:91420935"
                     /locus_tag="CP976_RS33330"
                     /old_locus_tag="CP976_33340"
     CDS             3498..4985
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91420935"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1038: phenylalanine-specific permease"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003993750.1"
                     /locus_tag="CP976_RS33330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_33340"
                     /product="amino acid permease"
                     /protein_id="WP_150483636.1"
                     /transl_table=11
                     /translation="MTGQQPPAPAAGAPSAEPGSEFRKDMGPWANFALGFTYLSPVVGT
                     YTLFGIAIADGGPPMIWAFLVAGCGQFLVALIFGEIVAQYPIAGGVYPWARRLWGKRWA
                     WMTGWVYMWALLVTITSVAYGAGPYIAILFGFRATVHTTVLCTAVLIVVAILINYLGTK
                     ALSVAALIGFAGELIGALVVGVYLLATHRHQGLGVIFDSYGTGGDGSYLPAFLAAAIIG
                     LYQYYGFEACGDTAEEVAHPGRVIPRAMRRTIYIGGAAATFTCMSLLLSVTDFNAIISG
                     EQADPVVDVLYDAMGETGARLVMAVVLISFLSCTISLQAAAGRLIYSYARDEMIVGYRL
                     LRRFVHTRAVPSWALFVSAAVPLIIAFASLLSEDALTNIVSFAILGIYGSFQMVVLAAL
                     RARLKGWKPAGEFTLGRWGLTVNIAALAYGILAIINICWARTPEKSWWENWIVLLCGAV
                     VVGTGVLYMFTTHHYGRGDALAGDAVPKEEKEAASKG"
     gene            complement(5001..6440)
                     /db_xref="GeneID:91420936"
                     /locus_tag="CP976_RS33335"
                     /old_locus_tag="CP976_33345"
     CDS             complement(5001..6440)
                     /codon_start=1
                     /db_xref="GeneID:91420936"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010034053.1"
                     /locus_tag="CP976_RS33335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_33345"
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_150483637.1"
                     /sec_met_domain="DUF692 (E-value: 1.8e-96, bitscore: 321.4,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MERLGTGIGWRPEIADAIERMPGIDWVEAVAENVCPGHLPDSLRR
                     LRERGVTVVPHGVSLGLGGADRPDEGRLTALAERAEALGSPLVTEHIAFVRAGGALTAT
                     PHLEAGHLLPVPRTRDALDVLCENVRIAQEALPVPLAVENIAALFSWPGEEMTEGQFLY
                     ELADRTGVRLLIDVANLHTNHVNRAEDPAKALAELPLEAIAYVHVAGGFERDGVWHDSH
                     AHPVPRPVLDVLTDLASRVSPPGVLLERDENFPEPAELEAELASIRRAVEAGAVERVKA
                     EVRAAGHAVAAGRPEAAAGGWSEVRADVPARGYGATPQGHQTGAAGATRGASGRPEHTG
                     VDEARQRLGLAQAALLSALVAGTPVPEGFDRARVGVQARALAAKRADVVAKVAPELPEI
                     LGVDYRTAFLAYAQTQPMTGGYRRDALTFAERLLSAGRPGDVAARRELREWWLDRSGPA
                     PRSRRPVRRLARATRKVLLRR"
     misc_feature    6539..6557
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 22.73"
                     /tool="antismash"
     gene            6648..7187
                     /db_xref="GeneID:91420937"
                     /locus_tag="CP976_RS33340"
                     /old_locus_tag="CP976_33350"
     CDS             6648..7187
                     /GO_function="GO:0005267 - potassium channel activity
                     [Evidence IEA]"
                     /GO_process="GO:0034220 - monoatomic ion transmembrane
                     transport [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91420937"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010034054.1"
                     /locus_tag="CP976_RS33340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_33350"
                     /product="potassium channel family protein"
                     /protein_id="WP_150483638.1"
                     /transl_table=11
                     /translation="MSDGSEQAAPVSTRRLWAGAGGLVVVVGTAYFLLPLEGLGADRPW
                     LGWPLFALCLGLLAALLLRQVRDVVLEKPHTRPGVMIPLLMCLAVLVFSSGYYALAQRP
                     GQFTGLNTRVDALYFTVVTLATVGYGDITPSGQEARLVAVAQILYAFVFLTAAATALSR
                     RLHAVVAARDRRPPPS"
     gene            complement(7221..7676)
                     /db_xref="GeneID:91420938"
                     /locus_tag="CP976_RS33345"
                     /old_locus_tag="CP976_33355"
     CDS             complement(7221..7676)
                     /codon_start=1
                     /db_xref="GeneID:91420938"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010034057.1"
                     /locus_tag="CP976_RS33345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_33355"
                     /product="hypothetical protein"
                     /protein_id="WP_150483639.1"
                     /transl_table=11
                     /translation="MSSAAPPPPAPPAPDDRTPGGPGGSGDPLATGGLALGGTLMVVYG
                     LFAVLQGITAIADDEVYTSFGEYVFEFDLTAWGWIHLIVGVLVVAAGFGLFTGAGWARV
                     VGAVVVGLALIANFMWLPYQPFWSIIMILTGLFVLWSLFNYRSTRSA"
     gene            complement(7747..8508)
                     /db_xref="GeneID:91420939"
                     /locus_tag="CP976_RS33350"
                     /old_locus_tag="CP976_33360"
     CDS             complement(7747..8508)
                     /EC_number="3.1.1.29"
                     /GO_function="GO:0004045 - aminoacyl-tRNA hydrolase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91420939"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010034059.1"
                     /locus_tag="CP976_RS33350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_33360"
                     /product="aminoacyl-tRNA hydrolase"
                     /protein_id="WP_167537470.1"
                     /transl_table=11
                     /translation="MSEDPTPVSDSPFRSEHSDRDTAPQFVLPLVVRIERADPPARTDA
                     LETAARAVLTILGDERSAGDGAWAEAMRDWQDTRIRKVVRRARGAEWRRAEALPGITIT
                     GKAAEVRVFPPVPLDGWPKDLARLQVSGTDLDDPEPPVDADPTAAVLWLNPDLGMSAGK
                     AMAQAGHAAQLAWWELPDEERAAWQDAGFPLSVRTADPARWPGLTRSGLPLVRDAGFTE
                     IAPGSCTVVADHPALRREPYAPGGPAPTRSE"
     gene            8551..9417
                     /db_xref="GeneID:91420940"
                     /locus_tag="CP976_RS33355"
                     /old_locus_tag="CP976_33365"
     CDS             8551..9417
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91420940"
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003993754.1"
                     /locus_tag="CP976_RS33355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_33365"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_150483641.1"
                     /transl_table=11
                     /translation="MRPDLCLENAGRRYGLRGPWVLRGVDLTVAPGRLVRVEGGNGTGK
                     STLLRLLAGIDAPSEGRITGRPRTAYVPERFPPALPFTAAGYLTHLGTVHGLTRAAATR
                     AAAEWLERLGAAAYADTPLARLSKGSSQKVAVAQALLGEPELLVLDEAWTGLDTDARAE
                     LERAVAERTAAGGSVVFVDHDPRRLAGLPDATYTVRDGSLAERAGPGPLPSGPQVTVEV
                     QGPPDGRLPDDVRRTVTAAEETAPGSHRLTVPAPHSDVLLRALLTAHPPWHVVRVERQA
                     DAPGSRR"
     misc_feature    8614..8616
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            9414..10085
                     /db_xref="GeneID:91420941"
                     /locus_tag="CP976_RS33360"
                     /old_locus_tag="CP976_33370"
     CDS             9414..10085
                     /codon_start=1
                     /db_xref="GeneID:91420941"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003997023.1"
                     /locus_tag="CP976_RS33360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_33370"
                     /product="ABC transporter"
                     /protein_id="WP_150483642.1"
                     /transl_table=11
                     /translation="MTALLRYHAALLLRSQRWLPPFLLYAAFLAVSVQAGQPVLDSLGY
                     SAAALLPVAAWLARICATAEPQAARGCVAAAVGPARAHVACLLVALSGAAALGTVATLG
                     VTLLSAPVASDHRTPVPLAPACGAGLLAALACALLGTAVGALTSRPLLRSRGRAVLAML
                     LAALLSLVATGSPAQAAVQGLVTGSRSGTVPLPLLPLAAAALLTAAALALAGALAARRS
                     P"
     gene            complement(10077..10256)
                     /db_xref="GeneID:91420942"
                     /locus_tag="CP976_RS33365"
                     /old_locus_tag="CP976_33375"
     CDS             complement(10077..10256)
                     /codon_start=1
                     /db_xref="GeneID:91420942"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675663.1"
                     /locus_tag="CP976_RS33365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_33375"
                     /product="hypothetical protein"
                     /protein_id="WP_150483643.1"
                     /transl_table=11
                     /translation="MSENDYCLIDATRPPRAEGPPYAECVLCREPTEYPESYKGITLCP
                     VCEWQEAQRTACSG"
     gene            complement(10275..11126)
                     /db_xref="GeneID:91420943"
                     /locus_tag="CP976_RS33370"
                     /old_locus_tag="CP976_33380"
     CDS             complement(10275..11126)
                     /GO_function="GO:0016810 - hydrolase activity, acting on
                     carbon-nitrogen (but not peptide) bonds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91420943"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1235: polysaccharide deacetylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010034067.1"
                     /locus_tag="CP976_RS33370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_33380"
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="WP_150483644.1"
                     /transl_table=11
                     /translation="MIILLRRVAAVCALSAVLAACGTGRPPRAAPPASAPPSRPPTLVP
                     GPAGLTPVFEHGPRTRGRTVALTFDADMTAGQGARAAAGERFDHPRLISTLRALKVPAT
                     VFMTGRWAEQYPDQARSIGRDPLFEVANHSYSHYAYTRDCYGLPTVPEGRMRSDVERAY
                     AAFRKAGVTDPMPYFRFPGGCYDRRALKALTPAGVTAVQWDVVGGDAFESDPDVVARQV
                     LDGVRPGSVVVLHCTRSAAPATERAVRAIVPELRREGYRFVKVSELIGAADSGARTRPE
                     AR"
     misc_feature    complement(11115..11130)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 18.09"
                     /tool="antismash"
ORIGIN
        1 gccgctgacg atgcctcggc ccttgacggg gggtcgcggt cgcatggtgg tgcctcctgg
       61 tacggcaccg cacgctagtg cgcttcgggg ccggagttga catgttactg cggggtctac
      121 gtcaactgcc gtacgagggc gaagggttgt atcgggggca gggcgggacg attgggggag
      181 gcggaacagg ggactcgccg gggcaaagag gcttaaaaca ttccatggtt ccaggcgggc
      241 gtgacccggg tgttagcccc ggcacactcg cgtgcgcacg ggcgaggccg ggtgactagc
      301 ccacccgggt cctctgggcc accgggacgc cgccggggcg gtgcgccccg tggccgccgc
      361 ccgcccgatg ggccatgttg ctgaccgtcg agccgatcgg caccggccgg atgcgaagga
      421 ggccccgcgg tgggcgagct gtacatcgac ggcgagtgga cccaggcggc ggccggtggc
      481 cggcgggagg tggtcaaccc ctacgacgcg tccgtcgtca ccaccgtcga cgaggccgac
      541 gccaccgacg tggaccgcgc cgtgcgcgcc gcccggcgcg ccttcgacga ggaggactgg
      601 gcgaacgcca cctcccgcca ccgggccgac ctcctgctgc gcgtccgcga cctgctgctg
      661 cgcgaccagg aggacatcgc ccgcaccgag accctcgaca ccggcaagac gctggccgag
      721 gcccgcatcg acgtggagga cgtggcgaac gccttccgct actacgccga actcgcgggc
      781 aaggacggcg gccgggtcgt ggacgtcggc ccggacgtcc tcagccgcgt cgtctaccag
      841 ccggtcggcg tctgcgcgct catcgccccc tggaactacc cgctgctcca ggcctcctgg
      901 aaggtcgccc cggcgctggc cgccggcaac accttcgtcc tcaagcccag cgagaccaca
      961 ccgctcacca cgatcgccat gatccggctc atcgaggagg ccggcgcacc gcccggcgtc
     1021 gccaacctgg tgctgggctc cggggcgacc gtaggcgcgg ccctgatcag ccaccccgag
     1081 gtcgacctgg tgtccttcac cggcggcctg accaccgggc ggtccatcat ggccggcgcc
     1141 gccgagggcc cgcgcaacat cgcgctcgaa ctcggcggca agaaccccaa catcgtcttc
     1201 gcggacgccg acttcgacgc cgccgtggac tacgcgctgg acgccgcctt cctgcattcc
     1261 gggcaggtct gctcggccgg ttcgcgcctg ctggtccagg actcgctgca cgacgggttc
     1321 gtcgaggccc tcgcccgccg cgcccaggcc atccggctcg gcaacggcat ggcggagggc
     1381 accgagagcg gcccgctcag ctccgccgag caccgcgaga aggtcgagcg ctacatcgcc
     1441 atcgcccagg aggagggcgc ccgcctcgtc accggcggca cccgccccga cgaccccgcc
     1501 ctgagccgcg gcttcttcct gctgccgacg atcttcgccg actgcgaccg gtcgatgcgg
     1561 atcgtccagg aggaggtctt cggcccggtg gtcaccgtcg agcgcttcgg caccgaggac
     1621 gaggcggtgg aactggccaa cgacacgcgc tacggcctgg ccggcggggt gtggacctcc
     1681 gacgcgagcc gcgcccagcg cgtcgcccag cggctgcggc acggcaccgt ctggatcaac
     1741 gacttccacc cctacgtgcc gcaggcggag tggggcggct tcggccgctc cggcgtcgga
     1801 cgcgaactcg gccccaccgg gctgcgcgag taccaggagg ccaagcacat ctaccagaac
     1861 ctcgcccccg ccccctccgg ctggttcaag ggctgaacga cacagaaagc agggcaccgc
     1921 atggccccca ccaccgcgca cggcgccgag tccgcctacg actacgtcat cgtcggcggc
     1981 ggcaccgccg gctgcgtgct cgccgcccgc ctgagcgagg accccgactg ccgcgtctgc
     2041 gtcgtcgagg gcggccccag cgacgtcggc gacgagcgca tcctgcgcct gcgcaactgg
     2101 atcaacctgc tgggctcgga gttcgactac ggctacacca ccgtcgagca gccgcgcggc
     2161 aactcccaca tcctgcactc acgggcccgc gtcctcggcg gctgctcctc gcacaacacc
     2221 ctgatcagct tcctgccgct gccgcaggac ctcgacgact gggtgaacgg gggctgcacc
     2281 ggctgggacc cggcgacgat cctcccctac cgcgaccggc tgctcacccg gatcgtcccg
     2341 gtggccgagg ccgaccgcaa tcccatcgcc aaggacttcg tcaccgccgc ctcccgcgcc
     2401 ctcggcgtcc ccgtcgtcga cgacttcaac gccgagccct tcgccgacgg caccggcttc
     2461 ttctccctgg cctaccagcc cgagggcaac ctgcgctcct ccgcgtccgt cgcctacctc
     2521 caccccgtcc tggaccggcc caacctcacc ctcctgctgg agacctgggc gcaccggctg
     2581 ctccccgacg agtcgggccg gctgacccgc gtcgccgtcc gtggcgccga cggcgaaccc
     2641 ggcaccgtgc gcgccgagcg tgaactcctc ctgtgcgcgg gtgccatcga caccccgcgc
     2701 ctgctgatgc tctccggact cggcccggcc gacgacctgc gcggcctggg catcgacgtc
     2761 cgggccgacc tgcccggcgt gggcgagaac ctgctggacc accccgagtc cgtgatcgtc
     2821 tgggagacgg aggggccgct gccgcccaac tccgcgatgg actccgacgc cggcctgttc
     2881 ctgcgccgcg accagggcca gccgcgcccc gacctgatgt tccacttcta ccaggtgccg
     2941 ttcaccgtca acaccgagcg cctgggctac cccgtgccgc cgtacggggt gtgcatgacg
     3001 cccaacgtgc cgcgcgcccg ctccaccggc cgcatgtggc tgcgcagctc cgaccccgcc
     3061 gagcatcccg ccctggactt ccggtacttc accgaccccg aggggcacga cgaacgcacc
     3121 atcgtggagg ggctgaaggt cgcccgcgag gtcgccgcca ccgccccgct gcgcgactgg
     3181 ctcgtccgcg aggtggcgcc cggcccggac gtcgtctccg acgccgacct ctcggagtac
     3241 ggccgccgcg cggcgcacac cgtctaccac ccggcgggca cctgccgcat gggcgcaccg
     3301 gacgacccga tggccgtgtg cgacgcggag ttgagactgc tcggcgtcga gggcgtgcgg
     3361 atcgtcgacg cgtcggtgtt cccgacgatg cccaccatca acccgatggt gaccgtcctg
     3421 ctcgccgccg aacgcgccgc cgatctgatc agcgaccgcc ccggccccac ggaacagtcg
     3481 aaacaggagg cccgccagtg accggtcaac agccccccgc accggcggcc ggggccccct
     3541 cggccgagcc cggctcggag ttccgcaagg acatgggccc ctgggccaac ttcgccctcg
     3601 gcttcaccta tctctccccg gtggtgggca cctacaccct cttcggcatc gcgatcgccg
     3661 acggcggacc gccgatgatc tgggcgttcc tggtcgccgg ctgcggccag ttcctcgtcg
     3721 cgctgatctt cggcgagatc gtcgcccagt acccgatcgc gggcggtgtc tacccctggg
     3781 cccggcggct gtggggcaag cgctgggcgt ggatgaccgg ctgggtgtac atgtgggcgc
     3841 tgctggtgac catcacctcc gtcgcctacg gcgccggccc ctacatcgcc atcctcttcg
     3901 gcttcagagc caccgtgcac accaccgtgc tgtgcaccgc cgtgctcatc gtcgtcgcca
     3961 tcctcatcaa ctacctgggc accaaggcgt tgtcggtggc ggcgctcatc ggtttcgccg
     4021 gcgagctcat cggcgccctc gtcgtcggcg tctacctgct ggccacccac cgtcaccagg
     4081 gcctcggcgt catcttcgac tcctacggca ccgggggaga cggctcctac ctgccggcgt
     4141 tcctggcagc cgccatcatc ggcctctacc agtactacgg cttcgaggcg tgcggcgaca
     4201 ccgccgagga ggtcgcccac cccggccggg tcatcccccg cgcgatgcgc cgcaccatct
     4261 acatcggcgg cgcggcggcc acgttcacct gtatgtcgct gctgctgtcg gtcacggact
     4321 tcaacgcgat catctcaggc gagcaggccg acccggtggt ggacgtgctg tacgacgcca
     4381 tgggcgagac cggggcgcgg ctggtgatgg ccgtggtgct gatctccttc ctgtcctgca
     4441 cgatcagcct ccaggccgcg gccgggcggc tcatctactc ctacgcccgt gacgagatga
     4501 tcgtcgggta ccggctgctg cggcggttcg tccacacccg cgccgtgccg agctgggcgc
     4561 tgttcgtgtc cgcggcggtg ccgctgatca tcgccttcgc ctcgctgctc tccgaggacg
     4621 ccctcaccaa catcgtctcg ttcgcgatcc tcggcatcta cggctcgttc cagatggtgg
     4681 tcctggccgc gctgcgcgcc cggctcaagg gctggaaacc ggcgggggag ttcaccctgg
     4741 gccgctgggg actcacggtg aacatcgccg cgctggccta cggcatcctc gccatcatca
     4801 acatctgctg ggcccgcacc ccggagaagt cctggtggga gaactggatc gtcctgctgt
     4861 gcggagcggt ggtggtgggt accggcgtgc tgtacatgtt caccactcac cactacggcc
     4921 gcggcgacgc acttgccggt gacgcggtgc cgaaggagga gaaggaggcc gcgtcgaagg
     4981 gctgacgggc ggtccccgcg tcaacgccgc agcagtacct tccgggtggc gcgggccagc
     5041 cggcggaccg ggcgtcgcga tcgcggcgcc ggtcccgacc ggtccagcca ccactcccgg
     5101 agttcccggc gcgccgcgac gtccccgggc cgcccggcgg acaggaggcg ctcggcgaag
     5161 gtgagggcgt cgcgccggta gccgccggtc atcggctggg tctgggcgta cgcgaggaag
     5221 gccgtacggt agtccacccc gaggatctcc ggcagttcgg gcgcgacctt cgccacgaca
     5281 tccgcccgct tggcggccag ggcccgcgcc tgtacgccga cccgcgcccg gtcgaacccc
     5341 tcgggcacgg gcgtccccgc gaccagcgcg gacagcagtg cggcctgcgc gagcccgagc
     5401 cgctgccggg cctcgtcgac gcccgtgtgt tcgggccggc cggaggcgcc ccgtgtcgcc
     5461 ccggccgccc cggtctgatg gccctgcggc gtcgccccgt agccgcgcgc gggaacgtcg
     5521 gcgcggacct cgctccagcc tccggccgcc gcctccggtc gccccgcggc gaccgcatgg
     5581 cccgccgcgc gcacctccgc cttcacccgc tcgacggccc ccgcctccac ggcccgccgg
     5641 atcgaggcca gctcggcctc cagctccgcc ggttccggga agttctcgtc gcgttccagc
     5701 aggacccccg gaggggagac gcgggatgcg aggtcggtca ggacgtccag gaccggacgg
     5761 gggacggggt gggcgtgact gtcgtgccag acgccgtcgc gttcgaagcc gccggcgaca
     5821 tggacgtagg cgatggcctc caggggcagc tcggcgaggg ccttggccgg gtcctcggcg
     5881 cggttgacgt ggttggtgtg caggttggcc acgtcgatga ggagccggac gcccgtgcgg
     5941 tcggccagct cgtacaggaa ctggccctcc gtcatctcct cgccgggcca ggagaacagc
     6001 gcggcgatgt tctcgacggc cagcggcacc ggcagcgcct cctgcgcgat gcgcacgttc
     6061 tcgcacagca cgtcgagcgc gtcccgggtc cgggggacgg gcagcagatg gcccgcctcc
     6121 aggtgcgggg tcgccgtcag agcaccgccg gcccgtacga acgcgatgtg ctcggtgacc
     6181 agcggcgagc cgagtgcctc tgcccgttcg gccagcgcgg tcagacggcc ttcgtcgggg
     6241 cggtccgcac ctccgaggcc gagcgagacg ccgtgcggca ccacggtgac gccgcgctcg
     6301 cgcagccgcc gcagcgagtc gggcagatgg ccggggcaga cgttctcggc cacggcctcg
     6361 acccagtcga tgcccggcat gcgctctatg gcgtccgcga tctccggtcg ccacccgatg
     6421 cccgtcccca gtcgctccat cgtcccctcc tccgcaccgc cggttcctcg aacgtgaggg
     6481 gggtatggcc cagccgcccg tccccgaacc ccgccacggg caccttcaga ggaacatttg
     6541 aggttcggcc caccgacgga tcaccgacgg atcactgacg gatctccggc tccaccgtcg
     6601 gaggcgccgg ggtcgcgcca ccccctgatg cgtcgtagac cggacgcatg agcgacggca
     6661 gcgaacaggc ggccccggtc tcgacgcggc ggctgtgggc cggggccggg ggactggtgg
     6721 tggtcgtcgg cacggcctat ttcctgctcc cgctggaggg gctcggcgcc gaccgcccct
     6781 ggctgggctg gccgttgttc gcattgtgcc tggggttgct ggccgcgctg ctgctgcgcc
     6841 aggtgcgcga cgtcgtgctg gagaagccgc atacccggcc gggcgtgatg atcccgctgc
     6901 tgatgtgcct ggccgtgctg gtcttctcgt cggggtacta cgccctcgcc cagcggccgg
     6961 gccagttcac cggcctgaac acccgcgtgg acgcgctgta cttcaccgtc gtcacgctcg
     7021 cgaccgtcgg ctacggggac atcaccccga gcgggcagga ggcccgcctg gtggccgtcg
     7081 cccagatcct ttacgcgttc gtcttcctca cggcggcggc caccgcgctg tcgcgccggc
     7141 tgcacgcggt ggtcgccgcg cgcgaccggc gcccgccgcc ctcctgaccc ggggcggccg
     7201 gggacggcag ggcgcggcgc ctacgccgag cgggtggagc ggtagttgaa cagcgaccac
     7261 agcacgaaca ggccggtcag gatcatgatg atcgaccaga acggctggta gggcagccac
     7321 atgaagttcg cgatcagcgc cagtccgacc acgaccgcgc ccacgacccg ggcccagccg
     7381 gccccggtga acaggccgaa cccggccgcc accacgagca caccgacgat caggtggatc
     7441 cagccccacg cggtcaggtc gaactcgaag acgtactcgc cgaagctcgt gtacacctcg
     7501 tcgtcggcga tggccgtgat gccctggagc accgcgaaca ggccgtagac gaccatcagg
     7561 gtgccgccga gagcgagacc cccggtcgcc agggggtcgc cggaaccgcc ggggccgccg
     7621 ggcgtccggt cgtcgggggc gggcggggcg gggggagggg gcgcggcgct ggacatggct
     7681 gcctcctggg tcggggttgt ctggtaaccc cactggagca cccgcccgcc accggcgcgc
     7741 ctgcggctac tccgaacggg tgggcgccgg accgccgggc gcgtacggtt cccggcgcag
     7801 cgccgggtgg tccgcgacca ccgtgcacga gccgggcgcg atctccgtga accccgcgtc
     7861 gcggaccaac ggcaggccgc tgcgcgtcag tccgggccag cgggccgggt cggccgtgcg
     7921 tacggagagc gggaagcccg cgtcctgcca ggcggcccgc tcctcgtcgg gcagctccca
     7981 ccaggccagt tgcgcggcgt gcccggcctg cgccatcgcc ttgccggccg acatgccgag
     8041 gtcggggttc agccacagca cggcggcggt ggggtccgcg tccaccggcg gttccgggtc
     8101 gtccaggtcg gtgccggaga cctggagccg ggccaggtcc ttgggccagc cgtccagcgg
     8161 gaccggcggg aagacccgca cctcggccgc cttgccggtg atcgtgatgc cgggcagggc
     8221 ctccgcccgc cgccattcgg cgccgcgggc ccgtcgcacc accttgcgga tccgggtgtc
     8281 ctgccagtcc cgcatcgcct cggcccacgc gccgtcgccg gccgaccgct cgtcgccgag
     8341 gatcgtcagc acggcccgcg cggccgtctc cagcgcgtcc gtacgcgccg gcgggtccgc
     8401 ccgctcgatc cgcacgacca ggggcagcac gaactgcggt gccgtgtcgc ggtccgagtg
     8461 ctcggaacgg aaggggctgt cactcacggg cgtcgggtct tcgctcacga atcccagtgt
     8521 gccagccgga agatcgtgga ggatgggccc atgcgacccg acctgtgcct ggagaacgcg
     8581 ggccgccgct acggcctgcg cggcccctgg gtgttacgtg gtgtcgacct gaccgtggca
     8641 cccggccggc tcgtccgcgt cgagggcggc aacggcaccg gcaagtccac cctcctgcgg
     8701 ctgctcgccg gcatcgacgc ccccagcgag ggccggatca ccggccgccc gcgcaccgcg
     8761 tacgtccccg agcggttccc gccggccctg ccgttcaccg ccgccggcta cctcacccac
     8821 ctcggcaccg tgcacggcct gacccgcgcg gcggccaccc gcgccgccgc cgagtggctg
     8881 gagcgcctcg gcgccgccgc ctacgccgat acgccgctgg cacggctgtc gaagggcagc
     8941 agccagaagg tcgcggtcgc ccaggccctg ctcggggagc cggagctgct ggtgctggac
     9001 gaggcgtgga ccggcctgga caccgacgcc cgtgccgagc tggagcgggc ggtcgccgag
     9061 cgtacggcgg ccggcggatc cgtggtgttc gtcgatcacg acccgcgccg cctcgcgggc
     9121 ctgcccgacg cgacgtacac cgtgcgcgac gggagcctcg ccgagcgcgc cgggccggga
     9181 ccgctgccgt ccggaccaca ggtcacggtc gaggtccagg gcccgccgga cggacggctt
     9241 cccgacgacg tgcggcggac cgtcaccgcc gccgaggaga ccgcgccggg cagccaccgc
     9301 ctcaccgtcc ccgccccgca ctccgacgtc ctgctccgcg ccctgctcac ggcccacccg
     9361 ccctggcacg tggtgcgtgt ggagcggcag gctgacgccc ccgggagccg ccggtgaccg
     9421 ccctgctgcg ctaccacgcc gccctgctgc tgcgctccca gcgctggctg ccgccgttcc
     9481 tgctgtacgc cgccttcctc gccgtcagcg tccaggccgg acagccggtg ctcgactcgc
     9541 tcggctactc cgccgccgcg ctgctgcccg tcgccgcctg gctggcgcgg atctgcgcca
     9601 cggccgagcc gcaggccgcg cgcggctgcg tggcggcggc cgtcgggccc gcgcgcgccc
     9661 atgtggcctg cctgctggtg gcgttgtccg gtgcggcggc gctcggcacg gtcgcgaccc
     9721 tcggcgtgac gctgctgagc gctccggtcg cctcggacca ccgcaccccg gtgccgctcg
     9781 cccccgcctg cggggccggg ctgctcgccg ccctggcctg cgccctgctg ggcacggccg
     9841 tcggcgcgct caccagccgg ccactgctgc ggtcgcgggg ccgtgccgtc ctggcgatgc
     9901 tgctcgcggc gctgctgtcc ctcgtcgcga cgggctcccc ggcgcaggcg gcggtgcagg
     9961 gcctggtgac cggctcacgg tcgggcaccg tccccctgcc gctgctgccc ctggccgcgg
    10021 cagccctgct cacggccgcc gcgctggccc tggccggtgc gctcgccgcc cgcaggtcac
    10081 cctgagcagg cggtgcgctg cgcctcctgc cactcgcaga ccgggcagag ggtgatgccc
    10141 ttgtacgact ccggatactc cgtcggctcc cggcacagca cgcactccgc gtacggcggc
    10201 ccctccgccc ggggcggcct ggtcgcgtcg atcaggcagt agtcgttctc gctcatacct
    10261 ccagcgtagg ccggtcagcg tgcctccggg cgggtccgcg caccgctgtc cgccgccccg
    10321 atcagctcgg acaccttcac gaacctgtag ccctcgcggc gcagctcggg cacgatcgcg
    10381 cgtaccgccc gttcggtcgc cggggcggcg ctgcgcgtgc agtgcagcac caccacggac
    10441 cccggccgca ccccgtccag cacctgccgg gcgaccacgt ccgggtccga ctcgaacgcg
    10501 tcgccgccga ccacgtccca ctgcacggcg gtcacgccgg ccggtgtcag cgccttcagg
    10561 gcccgccggt cgtaacagcc tccggggaaa cggaagtacg gcatcggatc cgtcacgccg
    10621 gccttccgga aggcggcgta cgcccgctcc acgtccgacc gcatccgccc ctcgggcacg
    10681 gtcggcaggc cgtagcagtc ccgtgtgtag gcgtagtggc tgtaggagtg gttggcgacc
    10741 tcgaagagcg ggtcccggcc gatggaacgg gcctggtccg ggtactgctc ggcccaccgc
    10801 ccggtcatga acacggtggc gggcaccttc agcgcgcgca gcgtggagat caggcgcgga
    10861 tggtcgaacc gctcacccgc cgccgcccgt gccccctgcc cggcggtcat gtcggcgtcg
    10921 aaggtgagcg cgacggtcct gccgcgggtg cggggaccgt gttcgaagac gggggtcagg
    10981 ccggcggggc cgggcacgag ggtcggaggg cgcgagggtg gtgcggacgc cggcggggcc
    11041 gcccgcgggg gccggccggt cccgcaggcg gcgaggaccg cgctcagggc gcacacggcg
    11101 gcgacacggc ggaggagaat gatcaccgta tgaagatatg aacgggatcg tcctcttatg
    11161 cgcgtcggct gcgggcgtca cccggccgtc agaggtcccg ctgctccaag ggcttggtcg
    11221 ccgggccctg gatcaccttg ccgtccgtgt cgaagcggga gccgtggcag gggcactccc
    11281 aggcgcgttc ggcggagttg aaggcgacca ggcagcccag gtgggtgcag cgggcggaga
    11341 aggagtgcag gttgccgtcc tcgtcccggt agaccgcgag gcggtggtgg ccgtcggcgc
    11401 ggaccacggc cccctcgccg ggcggcaggg actccaccgg
//
