LOCUS       NZ_CP023694            22499 bp    DNA     linear   CON 13-JUL-2024
DEFINITION  Streptomyces coeruleorubidus strain ATCC 13740 chromosome, complete
            genome.
ACCESSION   NZ_CP023694
VERSION     NZ_CP023694.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces coeruleorubidus
  ORGANISM  Streptomyces coeruleorubidus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 9335698)
  AUTHORS   Lee,N. and Cho,B.-K.
  TITLE     Direct Submission
  JOURNAL   Submitted (27-SEP-2017) Biological Science, KAIST, 291 Daehak-ro,
            Daejeon 34141, South Korea
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 2.3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 50X
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_008705135.1-RS_2024_04_23
            Annotation Date                   :: 04/23/2024 03:16:00
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,499
            CDSs (total)                      :: 8,405
            Genes (coding)                    :: 8,179
            CDSs (with protein)               :: 8,179
            Genes (RNA)                       :: 94
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 73
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 229
            CDSs (without protein)            :: 226
            Pseudo Genes (ambiguous residues) :: 0 of 229
            Pseudo Genes (frameshifted)       :: 96 of 229
            Pseudo Genes (incomplete)         :: 175 of 229
            Pseudo Genes (internal stop)      :: 12 of 229
            Pseudo Genes (multiple problems)  :: 53 of 229
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 14:54:21
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6594531
            Orig. end                         :: 6617030
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP023694.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria available from Korean Collection for Type Cultures.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22499
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="23"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..22499
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22499
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12499](-)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12499)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     misc_feature    complement(1295..1309)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.18"
                     /tool="antismash"
     gene            complement(1372..1947)
                     /db_xref="GeneID:91420405"
                     /locus_tag="CP976_RS30600"
                     /old_locus_tag="CP976_30610"
     CDS             complement(1372..1947)
                     /codon_start=1
                     /db_xref="GeneID:91420405"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018567895.1"
                     /locus_tag="CP976_RS30600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_30610"
                     /product="ATP/GTP-binding protein"
                     /protein_id="WP_003993187.1"
                     /transl_table=11
                     /translation="MDFASSDAGRSTTSAKIVVAGGFGVGKTTFVGAVSEINPLRTEAV
                     MTSASAGIDDLTHTGDKTTTTVAMDFGRITLDQDLILYLFGTPGQDRFWFMWDDLVRGA
                     IGAVVLVDTRRLADCFPAVDYFENSGLPFVIALNGFDGQQPYTPDEVREALQIGPDAPI
                     ITTDARHRADAKSALITLVEHALMARLR"
     gene            complement(1928..2323)
                     /db_xref="GeneID:91420406"
                     /locus_tag="CP976_RS30605"
                     /old_locus_tag="CP976_30615"
     CDS             complement(1928..2323)
                     /codon_start=1
                     /db_xref="GeneID:91420406"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009190816.1"
                     /locus_tag="CP976_RS30605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_30615"
                     /product="DUF742 domain-containing protein"
                     /protein_id="WP_053668780.1"
                     /transl_table=11
                     /translation="MTPPPASHDPYAEPYEDEGDQPLVRPYAMTGGRTRPRYQLAIEAL
                     ISTTADPAALMGLLPEHQRICHLCREVKSVAEVSALLNMPLGVARILVADLAEAGLVAI
                     HQPGGDDATGAPDVTLLERVLSGLRKL"
     gene            complement(2435..2848)
                     /db_xref="GeneID:91420407"
                     /locus_tag="CP976_RS30610"
                     /old_locus_tag="CP976_30620"
     CDS             complement(2435..2848)
                     /codon_start=1
                     /db_xref="GeneID:91420407"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005311457.1"
                     /locus_tag="CP976_RS30610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_30620"
                     /product="roadblock/LC7 domain-containing protein"
                     /protein_id="WP_029181510.1"
                     /transl_table=11
                     /translation="MSQAAQNLNWLITNFVDNTPGVSHTVVVSADGLLLALSEGFPRDR
                     ADQLAAVASGLTSLTAGASRIFEGGDVAQTVVEMERGFMFLMSISDGSSLAVLAHPDCD
                     IGLVGYEMALLVDRAGAVLTPDLRAELQGSLLH"
     gene            complement(2858..6694)
                     /db_xref="GeneID:91420408"
                     /locus_tag="CP976_RS30615"
                     /old_locus_tag="CP976_30625"
     CDS             complement(2858..6694)
                     /codon_start=1
                     /db_xref="GeneID:91420408"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011030302.1"
                     /locus_tag="CP976_RS30615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_30625"
                     /product="nitrate- and nitrite sensing domain-containing
                     protein"
                     /protein_id="WP_150483222.1"
                     /transl_table=11
                     /translation="MQGRFKRDGSASAEPEPHGGTNRGPSAQHAQNQGPAGDGGERPGR
                     PGASAPTGPASPAPALKPPTGPAGPGPRIALRNWRISTRLVSLLALPVVAATSLGALRI
                     NDSMDSIQQLDNMKLLTDMTKQATELSAALQEERDQSAGPLAHGGKSTDFTVKGLREKT
                     DRARKNFLDSSEQIDSASKDGNLKGVREYLIQLAGELGDLEQIRKGAYASEDNSTQTIE
                     AYHRLIENLIDLSQDMAEATSNPDMIQRTRALAAFSSAKEYSSIQRAALAAALPASNTT
                     TGKLSPNDRLYAESALESQNSEIRSFKSIYGEDAAAELLKPIEDGGNSTIKATDTYAGR
                     ALVSASGLAQQDKRSYRDWLDDSSTKIQQMKNIEHTLLEEMEQKARELRSATERDAIIS
                     GALILIVLGVSLVGAFVVARSMIRSLRRLEETATKVASDRLPELVKQLSESDPQDVDTS
                     VESVGVHSRDEIGRVAAAFDDVHREAVRLAAEQALLRGNVNAMFTNLSRRSQGLIQRQL
                     SLISELESREADPDQLSSLFKLDHLATRMRRNGENLLVLAGEEPGRRWTRPVPLVDVLR
                     AAASEVEQYERIELASVPTTEVAGRVVNDLVHLLAELLENATSFSSPQTKVKVTGHALP
                     DGRVLIEIHDTGIGLSPEDLAAINERLASPPTVDVSVSRRMGLFVVGRLSQRHGIRIQL
                     RPSDSGGTTALVMLPVDVAQGGRKPQPKQGGQPPVGGSGPAAAQAAAGAAAARRAAGAG
                     GQGGGALGAGASGGGFGGGASSGGGRLAAGQGPRAALPGRDADGGRPGGGRGPQGPDKS
                     PSLFEQSAPPAPPQGRPAPAGAGYGQAPGAPQGLQAAGTNGPQDQGQGRGRQRPGNAEQ
                     GQGRRPQLPPRGGPRAELPGGDPQPRVPSWSDENAQPPVPRASLDTPRGHEEPDVSRTS
                     QMPRIDDRQGPGSTAEIPAVPRDDDRQGPGSPADYGTGGPQHADRFGLPGTDGSQGSGQ
                     FVRPDVYGAPAGHRDPSSTTGQYPAPQSYDNGSTGQYPAPRQDNGSTGQYPAPRQDNGS
                     TGQYPSPQSYDNGSTGQYPAPRQDNGSGRPTLPGPATPADPAGTGQFERPQVNGARGGA
                     DFGAPRPPAPQARPARQEPEALPPASGPGDGRTPLYDTLETNWFHGQQEQQQSNGSAPA
                     PQQPQGAGGPQRSAPAGWRSSPNDDLVRQAERVRQPAAGGVTTSGLPRRVPRANLVPGT
                     AQQQPQQSGPQISRAPDDVRGRLTNLRRGIAQGRQAGSTQTGSFPRPSHQQER"
     misc_feature    6689..6705
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 22.12"
                     /tool="antismash"
     misc_feature    7132..7146
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.01"
                     /tool="antismash"
     misc_feature    complement(7135..7150)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: strong, score: 18.39"
                     /tool="antismash"
     gene            7296..7487
                     /db_xref="GeneID:91420409"
                     /locus_tag="CP976_RS30620"
                     /old_locus_tag="CP976_30630"
     CDS             7296..7487
                     /codon_start=1
                     /db_xref="GeneID:91420409"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CP976_RS30620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CP976_30630"
                     /product="hypothetical protein"
                     /protein_id="WP_167537232.1"
                     /transl_table=11
                     /translation="MKTTTMFHKIANPRRTTLAHLDDADELQTPELPEHRVELPTQTAN
                     PKRTILTEVPVAAAAAAE"
     gene            7660..8436
                     /db_xref="GeneID:91420410"
                     /locus_tag="CP976_RS30625"
                     /old_locus_tag="CP976_30635"
     CDS             7660..8436
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91420410"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016432451.1"
                     /locus_tag="CP976_RS30625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_30635"
                     /product="fumarylacetoacetate hydrolase family protein"
                     /protein_id="WP_150483223.1"
                     /transl_table=11
                     /translation="MRIARFSIDGNVAFGAIEGEKQDELVLDIIKGIPFADFELSGTKV
                     PVGKVRLLPPVLPNKVVAFGRNYAEHAKELGNEVPQAPFAFFKPSTSVIGPGDEIQYPS
                     FSEEVHHEAELAVVIGRMCREVPRERVKDVIFGYTCANDITARDVQKREKQWARAKGFD
                     TSCPLGPWVETDLDPGDLTIQLTVNGQQRQLGRTSEMVHSIEDLIVNISEAMTLLPGDV
                     ILTGTPAGVGPLNVGDEVAVTIEGIGTLTNKVVKRG"
     gene            8429..9913
                     /db_xref="GeneID:91420411"
                     /gene="gltX"
                     /locus_tag="CP976_RS30630"
                     /old_locus_tag="CP976_30640"
     CDS             8429..9913
                     /EC_number="6.1.1.17"
                     /GO_component="GO:0009332 - glutamate-tRNA ligase complex
                     [Evidence IEA]"
                     /GO_function="GO:0004818 - glutamate-tRNA ligase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006424 - glutamyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91420411"
                     /gene="gltX"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004924953.1"
                     /locus_tag="CP976_RS30630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_30640"
                     /product="glutamate--tRNA ligase"
                     /protein_id="WP_150483224.1"
                     /transl_table=11
                     /translation="MASAPGTPVRVRFCPSPTGNPHVGLVRTALFNWAFAKHHQGTLVF
                     RIEDTDAARDSEESYTQLLDSMRWLGFDWDEGPEVGGPHAPYRQSQRMDLYKDVAAKLL
                     DAGHAYRCYCSQEELDTRREAARAAGKPSGYDGHCRELTDAQVAEFKAQGREPIVRFRM
                     PDETITFTDLVRGELTFTPENVPDYGIVRANGAPLYTLVNPVDDALMEITHVLRGEDLL
                     SSTPRQIALYKALIELGVAQQIPSFGHLPYVMGEGNKKLSKRDPQSSLNLYRERGFLPE
                     GLLNYLSLLGWSLSADQDVFTIDEMIAAFDIADVNPNPARFDLKKCEAINGDHIRMLDV
                     KDFTERCRPWLQAPFAPWAPEAFDEAKWQAVAPHAQTRLKVLSEITDNVDFLFLPEPVE
                     DEASWTKAMKEGSDALLRTAREKLEAADWTSAESLKEAVLAAGEAHGLKLGKAQAPVRV
                     AVTGRTVGLPLFESLEVLGKEKTLARIDAALARLTA"
     gene            complement(10001..10435)
                     /db_xref="GeneID:91420412"
                     /locus_tag="CP976_RS30635"
                     /old_locus_tag="CP976_30645"
     CDS             complement(10001..10435)
                     /codon_start=1
                     /db_xref="GeneID:91420412"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018090021.1"
                     /locus_tag="CP976_RS30635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_30645"
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_150483225.1"
                     /sec_met_domain="PF13471 (E-value: 5e-27, bitscore: 93.2,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVPVTLTEQRRLPPHRRALPLLAVALARPLADIRPARLRRVLEL
                     ARRGAKPATVGQALAAREAVVSVSLRCAGQHCLQRSIATALLCRFRGVWPTWCTGVRTQ
                     PFAAHAWVEAEDQLIGESYPKGHYKPLLTIGPAPRKHPDH"
     gene            complement(10432..10692)
                     /db_xref="GeneID:91420413"
                     /locus_tag="CP976_RS30640"
                     /old_locus_tag="CP976_30650"
     CDS             complement(10432..10692)
                     /codon_start=1
                     /db_xref="GeneID:91420413"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016640866.1"
                     /locus_tag="CP976_RS30640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_30650"
                     /product="lasso peptide biosynthesis PqqD family chaperone"
                     /protein_id="WP_167537453.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 3.4e-27,
                     bitscore: 93.2, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 4.1e-15, bitscore: 54.8,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPLHLHPDVVTTETDDGTVLLQLHTGRYWQLNTTGTSVLRRLLDG
                     CAPDDIAAELARRHEIPPEQAEQDVQAILARLSSAGLVVAS"
     aSDomain        complement(10441..10686)
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_CP976_RS30640_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="1.10E-29"
                     /identifier="RREFam002.1"
                     /label="CP976_RS30640"
                     /locus_tag="CP976_RS30640"
                     /protein_end="84"
                     /protein_start="2"
                     /score="93.2"
                     /tool="antismash"
                     /translation="LHLHPDVVTTETDDGTVLLQLHTGRYWQLNTTGTSVLRRLLDGCA
                     PDDIAAELARRHEIPPEQAEQDVQAILARLSSAGLVV"
     gene            complement(10670..12499)
                     /db_xref="GeneID:91420414"
                     /locus_tag="CP976_RS30645"
                     /old_locus_tag="CP976_30655"
     CDS             complement(10670..12499)
                     /GO_function="GO:0004066 - asparagine synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006529 - asparagine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91420414"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016640865.1"
                     /locus_tag="CP976_RS30645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_30655"
                     /product="asparagine synthase-related protein"
                     /protein_id="WP_150483226.1"
                     /sec_met_domain="Asn_synthase (E-value: 3.9e-37, bitscore:
                     127.6, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPAFVILPDTTAAAVMRTRMSFASPQVVSHVSGRPWLVGSWSDDR
                     ITVATAGPVRVAVIGDCPISQERLTELTAAVTTVADVDKLASALPGSAHLMASVDGQVR
                     AQGSISGLSRIFYTRIDGVHVASDRAHVLAEMVGAVVDEQSLAVRLASGLALAPPLSER
                     CLWAGISSLAPERCLVWTRDQADEKVWWNPPAPHLSLRDGAAGVREALTGAVQDRAPAQ
                     GRVSADLSGGMDSTSLCFLAARHTPALLTLRWAEADAANDDADFAGQAIQALDRAEHLV
                     VAQRELPSIFDTESIPVDAEQPMLTMRAAARLRHNAQLLAQRGSRRHLAGHGGDELFQP
                     SPGYLAPLLRHHPVLALRRLRQNRALKRWSLRPALTGLLRPGTVAGWWHDQADNLHTVR
                     PQRAPAMGWGLHAVQAQSWMTPAGVDLIRQALRLTAHQAQPLSDDLGQHQTLLAVRTTA
                     AHYRLMARIYADVGVNLDLPYYDQRVLEAVLRVRPHEHADPRRYKPLLAEAMRGIVPPA
                     ILGRATKGEFGLDLRQGLADNLPSILNLFADSALAQRGLIDADTLRNRLLAPQRDLSMV
                     FALEALLGCELWLRTAARPARQPREHDAPAPAP"
     gene            complement(12506..12607)
                     /db_xref="GeneID:91420415"
                     /locus_tag="CP976_RS30650"
                     /old_locus_tag="CP976_30660"
     CDS             complement(12506..12607)
                     /codon_start=1
                     /db_xref="GeneID:91420415"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_103143102.1"
                     /locus_tag="CP976_RS30650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_30660"
                     /product="lasso RiPP family leader peptide-containing
                     protein"
                     /protein_id="WP_150485573.1"
                     /transl_table=11
                     /translation="MYVPPMLVEVGEFSEDTLGFGGWRLDSIFGIYT"
     misc_feature    12771..12786
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.19"
                     /tool="antismash"
     misc_feature    12781..12794
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.89"
                     /tool="antismash"
     gene            12833..13564
                     /db_xref="GeneID:91420416"
                     /locus_tag="CP976_RS30655"
                     /old_locus_tag="CP976_30665"
     CDS             12833..13564
                     /EC_number="3.1.3.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91420416"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1115: HAD-superfamily hydrolase, subfamily IA,
                     variant"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019328734.1"
                     /locus_tag="CP976_RS30655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_30665"
                     /product="HAD family hydrolase"
                     /protein_id="WP_150483227.1"
                     /sec_met_domain="HAD_2 (E-value: 3.4e-18, bitscore: 65.3,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSIRAVVWDVDDTLFDYTTADRLGMRTHLTAEGLLDDYDTVEQAI
                     TRWREITDAQWARFAAGEATFEDQRRDRVRVFLGQDLTDAEADAWFRRYRAHYEAVWAL
                     FPDVLPVLDALAASHRHAVLSNSSIHVQDRKLRVLGVHDRFESILCAAELGVSKPEAGA
                     FLAACAALDLSPHQVAYVGDHPEIDGRGAADAGLLSVWIDRGGAYATIDPPVGPHRIAS
                     LAELPSLLGSDSRFGAPSTFR"
     tRNA            13655..13726
                     /anticodon=(pos:6608219..6608221,aa:Gln,seq:ctg)
                     /db_xref="GeneID:91420417"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="CP976_RS30660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="CP976_30670"
                     /product="tRNA-Gln"
     gene            13655..13726
                     /db_xref="GeneID:91420417"
                     /locus_tag="CP976_RS30660"
                     /old_locus_tag="CP976_30670"
     tRNA            13767..13839
                     /anticodon=(pos:6608332..6608334,aa:Glu,seq:ctc)
                     /db_xref="GeneID:91420418"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="CP976_RS30665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="CP976_30675"
                     /product="tRNA-Glu"
     gene            13767..13839
                     /db_xref="GeneID:91420418"
                     /locus_tag="CP976_RS30665"
                     /old_locus_tag="CP976_30675"
     tRNA            13880..13952
                     /anticodon=(pos:6608445..6608447,aa:Glu,seq:ctc)
                     /db_xref="GeneID:91420419"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="CP976_RS30670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="CP976_30680"
                     /product="tRNA-Glu"
     gene            13880..13952
                     /db_xref="GeneID:91420419"
                     /locus_tag="CP976_RS30670"
                     /old_locus_tag="CP976_30680"
     tRNA            13973..14044
                     /anticodon=(pos:6608537..6608539,aa:Gln,seq:ctg)
                     /db_xref="GeneID:91420420"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="CP976_RS30675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="CP976_30685"
                     /product="tRNA-Gln"
     gene            13973..14044
                     /db_xref="GeneID:91420420"
                     /locus_tag="CP976_RS30675"
                     /old_locus_tag="CP976_30685"
     tRNA            14073..14145
                     /anticodon=(pos:6608638..6608640,aa:Glu,seq:ctc)
                     /db_xref="GeneID:91420421"
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="CP976_RS30680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="CP976_30690"
                     /product="tRNA-Glu"
     gene            14073..14145
                     /db_xref="GeneID:91420421"
                     /locus_tag="CP976_RS30680"
                     /old_locus_tag="CP976_30690"
     gene            complement(14321..15037)
                     /db_xref="GeneID:91420422"
                     /gene="ndgR"
                     /locus_tag="CP976_RS30685"
                     /old_locus_tag="CP976_30695"
     CDS             complement(14321..15037)
                     /codon_start=1
                     /db_xref="GeneID:91420422"
                     /gene="ndgR"
                     /gene_functions="regulatory (smcogs) SMCOG1195: IclR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011030305.1"
                     /locus_tag="CP976_RS30685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_30695"
                     /product="IclR family transcriptional regulator NdgR"
                     /protein_id="WP_020270051.1"
                     /transl_table=11
                     /translation="MDNSSGVGVLDKAALVLSALESGPATLAGLVGATGLARPTAHRLA
                     VALEHHRMVARDMQGRFILGPRLAELAAAAGEDRLLATAGPVLTHLRDVTGESAQLYRR
                     QGDMRICVAAAERLSGLRDTVPVGSTLTMKAGSSAQILMAWEEPERLHRGLQGARFTAT
                     ALSGVRRRGWAQSIGEREPGVASVSAPVRGPSNRVVAAVSVSGPIERLTRHPGRMHAQA
                     VIDAAGRLSEALRRTG"
     misc_feature    15052..15066
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 19.47"
                     /tool="antismash"
     misc_feature    15063..15077
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.17"
                     /tool="antismash"
     gene            15235..16665
                     /db_xref="GeneID:91420423"
                     /gene="leuC"
                     /locus_tag="CP976_RS30690"
                     /old_locus_tag="CP976_30700"
     CDS             15235..16665
                     /EC_number="4.2.1.33"
                     /GO_component="GO:0009316 - 3-isopropylmalate dehydratase
                     complex [Evidence IEA]"
                     /GO_function="GO:0003861 - 3-isopropylmalate dehydratase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009098 - leucine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91420423"
                     /gene="leuC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973442.1"
                     /locus_tag="CP976_RS30690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_30700"
                     /product="3-isopropylmalate dehydratase large subunit"
                     /protein_id="WP_150483228.1"
                     /transl_table=11
                     /translation="MGRTLAEKVWDDHVVRRAEGEPDLLFIDLHLLHEVTSPQAFDGLR
                     KSGRKVRRLDLTIATEDHNTPTLDIDKPIADPVSRIQLETLRKNAADFGVRLHPLGDVE
                     QGVVHVVGPQLGLTQPGTTVVCGDSHTSTHGAFGALAFGIGTSQVEHVLATQTLPMSRP
                     KTMAITVDGELPEGVTAKDLILAIIARIGTGGGQGYVLEYRGEAIEKLSMEARMTICNM
                     SIEAGARAGMIAPDETTFAYLKGRPHAPEGAEWDAAVEYWKTLRTDEDAEFDAEVVIDA
                     AELSPFVTWGTNPGQGAPLSASVPDPASYEDASERYAAEKALEYMGLEAGQPLRSIKVD
                     TVFVGSCTNGRIEDLRAAAELIKGRKVADGVRMLVVPGSARVGLQAVSEGLDVVFKDAG
                     AEWRHAGCSMCLGMNPDQLAPGERSASTSNRNFEGRQGKGGRTHLVSPQVAAATAVLGH
                     LASPADLADADTRTPAGV"
     gene            16671..17264
                     /db_xref="GeneID:91420424"
                     /gene="leuD"
                     /locus_tag="CP976_RS30695"
                     /old_locus_tag="CP976_30705"
     CDS             16671..17264
                     /EC_number="4.2.1.33"
                     /GO_component="GO:0009316 - 3-isopropylmalate dehydratase
                     complex [Evidence IEA]"
                     /GO_function="GO:0003861 - 3-isopropylmalate dehydratase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009098 - leucine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91420424"
                     /gene="leuD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018567905.1"
                     /locus_tag="CP976_RS30695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_30705"
                     /product="3-isopropylmalate dehydratase small subunit"
                     /protein_id="WP_059421950.1"
                     /transl_table=11
                     /translation="MEAFTTHTGRAVPLRRSNVDTDQIIPAHWLKKVTRDGFEDGLFEA
                     WRKDASFVLNQPERQGATVLVAGPDFGTGSSREHAVWALQNFGFKAVISSRFADIFRGN
                     SLKNGLLTVVLEQKIVDALWELTEKDPQAEITVDLVAREVRAEGITASFELDENARWRL
                     LNGLDDISITLQNEADIAAYEAKRPSFKPRTLPV"
     gene            17541..17771
                     /db_xref="GeneID:91420425"
                     /locus_tag="CP976_RS30700"
                     /old_locus_tag="CP976_30710"
     CDS             17541..17771
                     /codon_start=1
                     /db_xref="GeneID:91420425"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004983038.1"
                     /locus_tag="CP976_RS30700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_30710"
                     /product="hypothetical protein"
                     /protein_id="WP_020270054.1"
                     /transl_table=11
                     /translation="MEHDGQLELYTAVAGQLKEAHARVRALQVPEGVRMALTRKLLVIT
                     AAAKHDLADAARRLDRFTADLDEGRLPDEER"
     gene            17908..18543
                     /db_xref="GeneID:91420426"
                     /locus_tag="CP976_RS30705"
                     /old_locus_tag="CP976_30715"
     CDS             17908..18543
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0030261 - chromosome condensation [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91420426"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010044576.1"
                     /locus_tag="CP976_RS30705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_30715"
                     /product="HU family DNA-binding protein"
                     /protein_id="WP_150483229.1"
                     /transl_table=11
                     /translation="MNKAQLVEAIADKMGGRQQAADAVDHVLDAIVRAVVAGERVSVTG
                     FGSFEKVDRPARYARNPQTGERVRVKKTSVPRFRAGQGFKDLVSGSKKLPRGGEVSVKK
                     APKGSLTGGAGATVKKAAAKKATAKTAAAKKTTAKKAPAKKATTKTAAAKKTTAKKAPA
                     KTTTAKTTAAKKTTAKKAPAKKATAKKAPAKKSTARKTTAKKTTARKK"
     gene            complement(18615..18818)
                     /db_xref="GeneID:91420427"
                     /locus_tag="CP976_RS30710"
                     /old_locus_tag="CP976_30720"
     CDS             complement(18615..18818)
                     /codon_start=1
                     /db_xref="GeneID:91420427"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015657605.1"
                     /locus_tag="CP976_RS30710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_30720"
                     /product="hypothetical protein"
                     /protein_id="WP_150483230.1"
                     /transl_table=11
                     /translation="MQATAYTYDPESRSGQVLLDDGTPVPFDAAAFDAGGLRLLRPGQR
                     VRIEVEGPEEDFRITLVTLQTL"
     gene            complement(18828..19466)
                     /db_xref="GeneID:91420428"
                     /gene="cofC"
                     /locus_tag="CP976_RS30715"
                     /old_locus_tag="CP976_30725"
     CDS             complement(18828..19466)
                     /EC_number="2.7.7.68"
                     /GO_function="GO:0043814 - phospholactate
                     guanylyltransferase activity [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91420428"
                     /gene="cofC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019328741.1"
                     /locus_tag="CP976_RS30715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_30725"
                     /product="2-phospho-L-lactate guanylyltransferase"
                     /protein_id="WP_150483231.1"
                     /transl_table=11
                     /translation="MQWTLVVPLKPLAQAKSRLADTADDGLRPDLALAFAQDTVAAALA
                     CPAVRDVAVVTDDARAGRELAALGAAIIPDEPRSGLNAALAHAAGAVRSARPESPVAAL
                     NADLPALRPPELARVLDGAAQFPRAFLPDAAAIGTTLLAAAPGRQLSPAFGIDSRARHR
                     ASGAVELSLTAVDSVRQDVDTGDDLRTALALGVGPHTAAAAARLLIPGQ"
     gene            19624..20445
                     /db_xref="GeneID:91420429"
                     /locus_tag="CP976_RS30720"
                     /old_locus_tag="CP976_30730"
     CDS             19624..20445
                     /codon_start=1
                     /db_xref="GeneID:91420429"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1141: acyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010044570.1"
                     /locus_tag="CP976_RS30720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_30730"
                     /product="lysophospholipid acyltransferase family protein"
                     /protein_id="WP_150483232.1"
                     /transl_table=11
                     /translation="MPRRRIGFWYRFAAVICKPPLVVLLRRDWRGMEHIPAEGGFITAV
                     NHNSHIDPFAYAHFQYNTGRVPRFLAKSGLFNKGFVGAAMRGTGQIPVYRESTDALSAF
                     RAAIEAVDRGECVAFYPEGTLTRDPAGWPMTGKTGAARVALQTKCPVIPVAQWGCNELL
                     PPYEKKPHLLPRKTHRVLAGPPVDLTRFYDQEMTTELLKEATEVIMAAITRQLEEIRGE
                     KAPEMPYDPRRERIEQRRRTQAQTQRGTQQAASQVQSAQPAQSAQEEGLGK"
     gene            20442..21452
                     /db_xref="GeneID:91420430"
                     /locus_tag="CP976_RS30725"
                     /old_locus_tag="CP976_30735"
     CDS             20442..21452
                     /EC_number="1.1.1.94"
                     /GO_component="GO:0009331 - glycerol-3-phosphate
                     dehydrogenase complex [Evidence IEA]"
                     /GO_function="GO:0047952 - glycerol-3-phosphate
                     dehydrogenase [NAD(P)+] activity [Evidence IEA]"
                     /GO_function="GO:0051287 - NAD binding [Evidence IEA]"
                     /GO_process="GO:0046167 - glycerol-3-phosphate biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91420430"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016432440.1"
                     /locus_tag="CP976_RS30725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_30735"
                     /product="NAD(P)H-dependent glycerol-3-phosphate
                     dehydrogenase"
                     /protein_id="WP_150483233.1"
                     /transl_table=11
                     /translation="MSKPVKAAVLSAGSWGTAFGMVLADAGCEVTLWGRRPQVVEAINS
                     TRTNPDYFPGVELPENVRATTDPAEAAADADFTVLSVPSQTLRGNLADWAPLLAPGTVL
                     VSLMKGVELGSAMRMSEVIDDVAKVGPDRIAVVTGPNLAREIAARMPAAAVVACTDEAV
                     AQRLQVACHTPYFRPYTNTDVVGCELGGAVKNVIGLAVGIADGMGLGDNAKGSLITRGL
                     AETTRLGIALGADPLTFSGLAGLGDLVATCSSPLSRNHTFGTNLGKGMTLQETIAVTKQ
                     TAEGVKSCESVLDLARRHGVDMPITETVVGIVHEGKPPVVALKELMSRSAKPERR"
ORIGIN
        1 gctcgggtcc gtggtctgga gcgtcgcgat ggccgcgacc atcgtctccg gcttggaggg
       61 cggggggacg tagtccgggt ccttggcctt ggcttcccgg gccatcgcgg ccccgtcggt
      121 cttgagcttg gcctctgccg ccctgagctt ggccgcgtcc tgctcggtac cgccgccgat
      181 gtactcctgc acggcgatgc gctcgaggta ggcgtacgag gacagggcga tgcgctggct
      241 ggccaggttg ccgtcgtccg ggcccggctt ggtcaggatg tgcatgccga tggagcgctg
      301 gagcgacgat gccgccttgg tgagctcgat ggcgtacacg gtccggccgt agctggtgat
      361 gttgccggtg ccgaggccca gctcgttggc gaactccgtc agcgggtggg cgatctcgac
      421 gtagccctct tcggtctgta cgcccttgag cttggaggtg tacgcgacct ggcgcagggt
      481 ctgcagcttg ggctccgcct tgcggaacag gtccagacgg cgctccaggc cgggcttggc
      541 cggcatgttc tgggccgcgg cgtcgaaggc gtcggccgcc tcgtcggtgg tcttgcggac
      601 ctgggtgacg gtcgccttgt cctgggaggt ctgggcgctg cccttcagca ggggtgccgc
      661 ggaggtgtcg cgctcgttgt agagggcgtt ggcgtacagc agggaggccc gcaccagacg
      721 cgcggtgttc tccgcgtcct cggcctcctg ccaggtgtcg atcgagctct tcacctggaa
      781 gccgcccatg acgaggccga ccagcacggg tatgagcagg atggcgttga gcctggtcgc
      841 cactcgccag ttgcgcgggg agagacggcc gccgctctcg gcgggcgcgg ccgatggttc
      901 cgaacccggc acgggggcgg gcgccgctgt gcgcggcggc ggggtgaagt tgccccgggc
      961 cgacggctcg ggactgttct tgcttcgcct cactcgacca acaacctctc ggcggtcggc
     1021 accaacgttg tgccgcagtt tctcagagcc cggtgatgcc atcgactgac gtgtacgtca
     1081 ttgactattg ggcagttcag gcattccagc acgacgacct gcgctcttcc aaacagtccg
     1141 aggtggggat tccgagggat gtaagcccca gataaaacgg tcataaagaa cgagccccgc
     1201 caaaaggcgg ggcgattgtg cgcgcagcga gaccggatgt gcgcgacgcg tggccgtacc
     1261 accagattcc tctgccgaaa cgttatgaac accttggccg accgtgtcaa aggacacagt
     1321 cggctccggt gcatctacga caactgccgt attgcgcttc tgaattgggt gctacctcag
     1381 tcgtgccatc agagcgtgct cgaccagcgt gatcagggca ctcttcgcgt cggcccggtg
     1441 ccgggcgtcc gtcgtgatga tgggggcgtc cggaccgatc tggagagctt cccgcacctc
     1501 atcgggggtg tagggctgct ggccgtcgaa gccgttgagg gcgatgacga agggcaggcc
     1561 gctgttctcg aagtagtcga ccgcggggaa gcagtcggcg agacggcggg tgtccaccag
     1621 caccacggcg ccgatcgcgc cgcgcaccag atcgtcccac atgaaccaga agcggtcctg
     1681 gcccggcgta ccgaagaggt acaggatcag gtcctggtcc agggtgatac ggccgaagtc
     1741 catggccacc gtggtggtgg tcttgtcccc ggtgtgcgtg aggtcgtcga tgcccgcgct
     1801 ggcggaggtc atcacggcct ccgtgcgcag cgggttgatc tccgagacgg cgccgacgaa
     1861 cgtggtcttg cccacgccga agccgcccgc caccacgatc ttcgcggagg tggtcgaacg
     1921 acccgcgtca gagcttgcga agtccactga gcaccctttc gagcagtgtc acgtccggtg
     1981 cgccggtggc atcgtcgccg cccggctggt ggatcgcgac gagaccggcc tccgcgaggt
     2041 ccgcgaccag gatccgcgcc acacccagcg gcatgttgag cagggccgag acctcggcga
     2101 ccgacttcac ctcacggcac aggtggcaga tgcgctggtg ctccgggagc aaccccatga
     2161 gcgccgcggg atcggcggtc gtgctgatca gtgcctcgat ggccagttgg taacgcggcc
     2221 gcgtccggcc gcccgtcatg gcgtatggcc ggaccagcgg ctggtcgccc tcgtcctcgt
     2281 acggctccgc gtacggatca tgagaggcgg ggggcggggt catgggtcct ccgggcggga
     2341 cagcaagtcg gtcagtcgag ccgtctgacg aggcctgtgt ggggtgtgtg gcggccggac
     2401 ggtgatgtgg tgagacgggt ggtgccgggg ccgatcaatg gagcagactg ccttggagct
     2461 cagctcgcag gtcgggggtg aggaccgcgc ccgcgcggtc gaccaggagc gccatctcgt
     2521 agccgacgag gccgatgtcg cagtcggggt gggcgaggac cgccagcgac gagccgtccg
     2581 agatggacat gaggaacatg aatccccgct ccatctccac gaccgtctgc gcgacatcgc
     2641 ccccctcgaa gatccgggag gcacccgccg tcagggacgt caggccggag gcgacagccg
     2701 cgagctggtc cgcgcggtcg cgcgggaagc cctccgacag cgccaggagg agaccgtcgg
     2761 cggacacgac gacggtgtgg gacaccccgg gggtgttgtc cacgaagttg gtgatcaacc
     2821 agttcaggtt ctgtgccgcc tggctcatcg gactcaacta acgctcctgc tggtgagagg
     2881 gccgagggaa gctgccggtc tgggtggacc cggcttgacg accctgtgca ataccgcggc
     2941 ggagattggt cagccgaccg cggacgtcat cgggggcacg agagatctgc ggaccgctct
     3001 gctgtggttg ctgctgagcc gtgcccggaa cgaggttcgc ccggggcacc cggcgcggca
     3061 ggccggaggt ggtgacaccg ccggcggcgg gctggcggac gcgctcggcc tggcggacga
     3121 ggtcgtcgtt cggcgagctg cgccagccgg cgggggcgga ccgctgcgga ccgccggctc
     3181 cctgcggctg ctgcggggcg ggagccgagc cgttgctctg ctgctgctcc tgctggccgt
     3241 ggaaccagtt ggtctcgagc gtgtcgtaca gcggcgtacg cccgtcgccc ggaccggacg
     3301 ccggcggcag ggcctcgggc tcctgccgtg cgggccgtgc ctgcggggcg ggcggacgcg
     3361 gggcaccgaa gtcggctccg ccccgggcgc cgttgacctg cggccgctcg aactggcccg
     3421 tgcccgccgg gtcggccggg gtggccggac cggggagggt gggccggccg gagccgttgt
     3481 cctggcgcgg tgcggggtac tgaccggtcg agccgttgtc gtaggactgc ggagacgggt
     3541 actggcccgt ggagccgttg tcctggcgcg gcgcggggta ctgaccggtc gagccgttgt
     3601 cctgccgggg cgccgggtac tggcccgtgg agccgttgtc gtaggactgc ggagccgggt
     3661 actggcccgt cgtggacgac gggtcgcggt ggccggccgg ggcgccgtag acgtccgggc
     3721 ggacgaactg gcccgaaccc tgtgaaccgt ccgtgccggg aaggccgaaa cggtccgcgt
     3781 gctgggggcc gcccgtgccg tagtcggccg gagagccggg gccctgccgg tcgtcgtcgc
     3841 gcggcacggc ggggatctcc gccgtcgaac ccgggccctg gcggtcgtcg atccgcggca
     3901 tctgagaggt acgggagaca tccggctcct cgtgcccgcg cggggtgtcc agcgaggcac
     3961 gcggcaccgg cggctgggcg ttctcgtcgc tccagctcgg cacgcggggc tgcgggtcac
     4021 cgccgggcag ctcggcccgc ggaccgccgc gcggcggcag ctgcggccga cggccctgac
     4081 cctgctcggc gttgcccggg cgctgccggc ccctgccctg gccctggtcc tgcggtccgt
     4141 tcgtacccgc ggcctgcaga ccctgcggag cacccggcgc ctgaccgtac ccggcaccgg
     4201 caggtgccgg acggccctgc ggcggcgcgg gcggagcgct ctgctcgaac aacgacgggg
     4261 acttgtcggg accctgcggt ccgcgcccac cgcccggacg gccaccgtcc gcgtcccgcc
     4321 cgggcagcgc ggcccgcgga ccctggccgg cggcgagccg gccaccgccc gacgacgcac
     4381 cgccaccgaa gccgccaccg gaagcaccgg ctccgagggc gccaccgccc tggccgccgg
     4441 caccggcggc acgccgggcc gcggccgcac cggccgcggc ctgcgcggcg gccggaccgc
     4501 taccgccgac cggcggctga ccgccctgct tgggctgggg cttcctgccg ccctgggcga
     4561 cgtcgacggg gagcatgacc agcgcggtcg taccaccgga gtcggacggg cgcagctgga
     4621 tgcggatgcc gtgccgctgc gacagccggc cgaccacgaa cagacccatg cggcgggaga
     4681 cggagacgtc caccgtcggg ggagaggcga gccgctcgtt gatcgccgcc aggtcctccg
     4741 gcgacagacc gataccggtg tcgtggatct cgatcaggac gcggccgtcg ggcagggcgt
     4801 gaccggtgac cttgaccttg gtctgcggcg aggagaacga agtcgcgttc tccagcagct
     4861 cggcgagcag gtgcacgagg tcgttgacca cgcggccggc gacctcggtg gtcggcaccg
     4921 aggccagctc gatgcgctcg tactgctcca cctcggaggc ggcggcacgc agcacgtcga
     4981 ccagcgggac cgggcgggtc caccggcggc cgggctcctc acccgcgaga accagcaggt
     5041 tctcaccgtt acggcgcata cgcgtggcga ggtggtcgag cttgaacagc gaggacagct
     5101 ggtccgggtc ggcctcgcgg gactccagtt cggagatcag cgaaagctgg cgctggatca
     5161 gaccctggga gcggcgcgag aggttggtga acatcgcgtt gacgttgccc cgcagcaggg
     5221 cctgctcggc ggcgaggcgg accgcctcgc ggtgcacgtc gtcgaaggcc gcggccaccc
     5281 ggccgatctc gtcccgggag tgcacaccga ccgactccac ggacgtgtcg acgtcctgcg
     5341 ggtcggactc ggagagctgc ttgaccagct cgggcagccg gtcggaggcg accttggtcg
     5401 cggtctcctc caggcggcgc agcgagcgga tcatggagcg ggccacgacg aaggcgccga
     5461 ccagcgagac accgagcacg atgaggatca gggcaccgga gatgatcgcg tcgcgctcgg
     5521 tggcgctgcg cagctcgcgg gccttctgtt ccatctcctc gagcagggtg tgctcgatgt
     5581 tcttcatctg ctggatcttg gtggagctgt cgtccagcca gtcgcggtag gaccgcttgt
     5641 cctgctgggc gagaccgctc gcggagacca gggcccggcc cgcgtaggtg tcggtcgcct
     5701 tgatcgtgga gttgccgccg tcctcgatgg gcttgagcag ctcggcggcg gcgtcctcgc
     5761 cgtaaatgct cttgaagctg cggatctcgg aattctggct ctccagggcc gactcggcgt
     5821 agagccggtc gttcggcgag agcttgccgg tggtggtgtt gctcgcgggc agtgccgccg
     5881 ccagggccgc acgctggatc gaggagtact ccttggcgga ggagaacgcc gcgagcgcac
     5941 gcgtgcgctg gatcatgtcc gggttgctgg tcgcctcggc catgtcttgg gagaggtcga
     6001 tcaggttctc gatcagacgg tggtacgcct cgatcgtctg cgtggagttg tcctcggagg
     6061 cgtaggcacc cttgcggatc tgctccaggt cgcccagctc gccggcgagc tggatgaggt
     6121 actcgcggac gcccttgagg ttgccgtcct tgctggcgct gtcgatctgc tccgaactgt
     6181 cgaggaagtt cttcctcgcc cggtcggtct tctcgcgcag gcccttgacc gtgaagtcag
     6241 tcgacttgcc accgtgcgcc agcgggccgg ccgactggtc gcgctcctcc tggagggcgg
     6301 cggacagctc ggtggcctgc ttggtcatgt ccgtcagcag cttcatgttg tcgagctgct
     6361 gaatgctgtc catggagtcg ttgatgcgca gcgcgccgag cgaggtggcc gcgaccaccg
     6421 ggagggcgag cagcgagacc agacgggtgg agatgcgcca gttgcgcaga gctattcgcg
     6481 ggccggggcc ggccgggccc gtcggcggct tcagggccgg ggccgggctc gcgggccccg
     6541 tgggggccga cgcgccgggg cgcccggggc gttccccgcc gtcacccgcc gggccctggt
     6601 tctgggcgtg ctgggccgag ggacctcggt tggtcccgcc gtgcggctcc ggctccgccg
     6661 aagcgctgcc atccctcttg aaacgtccct gcactagcgt cgcaacctct ggaccaggcg
     6721 ccccatcgcg tgaacggtgg ggcacggtgt cggcgttctg gggacgccct gagtacgccc
     6781 ccgtggtggt cgtgagtgac cggcgctggc tcccccttct caccgccact cggcgcgtct
     6841 gtgcgccccc tgtgcgccgg ctcgatcctg cggcggtccg tggcattcca gcacagcaca
     6901 ggatctccaa caaggctcgt atgccaggcc gtgacatagg tgacaccacg tgagtgccga
     6961 atcaccggac gtagagagtg agttcgccca tttcgggcgt atgcccgcga gtcgccgagg
     7021 cctcatgggt gtcccagtcg ccatgatcag cagcggaatg agggcttcag ggggtcaatg
     7081 tccgtttcgt tgaggtcgga cgcgagcccg gattgaccga tttgccccct gattcgtgag
     7141 aaaactcaca tgctgatcat gaagtcctcg cgattacgcc gggaatccca tgtttagcct
     7201 gacgctttac agagatggca aaaccgacaa cccgcgcccg tgcgagggtc ctcgcgctct
     7261 cccggcgcct gtcacagaac aggatcaagt aaacagtgaa gacgacgacg atgttccaca
     7321 agatcgccaa cccgcgacgc acgacgctgg cgcacctgga cgacgccgac gaactgcaga
     7381 cgccggaact gccggagcac cgcgtcgaac tccccaccca gactgccaac cccaagcgca
     7441 ccatcctcac cgaggtcccc gtcgcggccg ccgctgccgc ggagtgacac cagggagtac
     7501 gcacaccggc cgccggatgc tcacggcggc gggacacaag catcgaaggg gcgtcccggc
     7561 gacggagcgc cccttcgtga tgcgcgcggc gcggaccctt ccccgcgtta gcctggagcg
     7621 tcagactcca gccgcttcag tcaaggggcc aagcatcccg tgcgcatcgc cagattctcc
     7681 atcgacggga acgtcgcctt cggcgccatc gagggcgaga agcaggacga actcgtcctg
     7741 gacatcatca agggcatccc gttcgcggac ttcgagctct ccggcacgaa ggtgccggtc
     7801 ggcaaggtga ggctgctgcc gccggtgctg cccaacaagg tcgtggcctt cggccgcaac
     7861 tacgccgagc acgcgaagga actgggcaac gaggtcccgc aggcaccctt cgccttcttc
     7921 aagccgtcca cctcggtgat cggtcccggc gacgagatcc agtacccctc cttctccgag
     7981 gaggtgcacc acgaggccga gctggccgtg gtcatcggcc ggatgtgccg cgaggtcccg
     8041 cgcgagcgcg tcaaggacgt gatcttcggc tacacctgcg ccaacgacat caccgcccgc
     8101 gacgtccaga agcgcgagaa gcagtgggca cgggccaagg gcttcgacac ctcctgcccg
     8161 ctcggcccct gggtggagac ggacctggac ccgggcgacc tgaccatcca gctcacggtc
     8221 aacggccagc agcgccagct cggccgcacc agcgagatgg tccactccat cgaggacctg
     8281 atcgtcaaca tctccgaggc catgacgctg ctccccggcg acgtgatcct cacgggcacc
     8341 ccggctgggg tcggccccct gaacgtcggc gacgaggtcg ccgtcaccat cgaaggcatc
     8401 ggcactctca ccaacaaggt tgtcaagcgt ggctagcgca cccggcactc ccgtacgcgt
     8461 ccgtttctgc ccgtcgccca ccggtaaccc ccacgtgggc ctggtgcgca ccgccctgtt
     8521 caactgggcg ttcgccaagc accaccaggg cacgctggtc ttccgcatcg aggacaccga
     8581 cgcggcccgc gactccgagg agtcgtacac ccagctcctc gactcgatgc gctggctggg
     8641 cttcgactgg gacgagggcc ccgaggtcgg cggcccgcac gcgccgtacc gccagtcgca
     8701 gcgcatggac ctgtacaagg acgtcgcggc caagctcctg gacgccggcc acgcctaccg
     8761 ctgctactgc tcccaggagg agctggacac ccgccgcgag gcggcccgcg ccgccggcaa
     8821 gccctccggc tacgacggcc actgccgtga gctgaccgac gcccaggtcg ccgagttcaa
     8881 ggcccagggc cgggagccga tcgtccgctt ccgcatgccc gacgagacga tcaccttcac
     8941 ggacctggtc cgcggcgagc tgaccttcac cccggagaac gtcccggact acggcatcgt
     9001 ccgcgccaac ggcgccccgc tctacacgct ggtcaacccg gtcgacgacg ccctgatgga
     9061 gatcacccac gtcctgcgcg gcgaggacct gctctcctcc accccgcgcc agatcgccct
     9121 gtacaaggcg ctgatcgagc tgggcgtcgc ccagcagatc ccgtccttcg ggcacctgcc
     9181 gtacgtgatg ggcgagggca acaagaagct ctccaagcgc gacccgcagt cgtccctgaa
     9241 cctctaccgc gagcggggct tcctccccga gggcctgctc aactacctct cgctgctcgg
     9301 ctggtccctc tcggccgacc aggacgtgtt cacgatcgac gagatgatcg cggccttcga
     9361 catcgcggac gtcaacccca acccggcccg cttcgacctg aagaagtgcg aggccatcaa
     9421 cggcgaccac atccgcatgc tcgacgtgaa ggacttcacg gagcgctgcc gcccatggct
     9481 ccaggcgccg ttcgccccct gggccccgga ggccttcgac gaggccaagt ggcaggccgt
     9541 cgccccgcac gcccagaccc gcctcaaggt gctctccgag atcaccgaca acgtcgactt
     9601 cctgttcctg ccggagccgg tggaggacga ggccagctgg acgaaggcca tgaaggaagg
     9661 ctctgacgcc ctgctgcgca ccgcccggga gaagctggag gcggccgact ggacctccgc
     9721 cgagtcgctc aaggaggccg tcctggccgc cggcgaggcc cacggcctca agctcggcaa
     9781 ggcccaggcc ccggtccgtg tcgccgtcac cggccgtacg gtcggcctgc cgctgttcga
     9841 gtcgctggag gtcctgggca aggagaagac cctggcccgg atcgacgcgg cgctggcgcg
     9901 gctgacggcc tgactcgtac atgggcaagg ggcggcagcc gtgtagcggc tgccgcccct
     9961 tatcgcgcgg ctacggtacc ggcgacgttg aacaccgtgc tcagtggtcg gggtgcttgc
    10021 ggggtgctgg gccgatggtc agaagcggtt tgtagtggcc tttcgggtaa ctctcaccga
    10081 tgagttgatc ttcggcttcg acccaggcat gggcggcgaa gggctgagtg cgcacccctg
    10141 tgcaccaggt cggccacaca ccgcggaacc ggcagagcag ggcggtggcg atggagcgtt
    10201 gcaggcagtg ctgcccggcg cagcgcaggc tgaccgacac caccgcttcg cgtgcggcga
    10261 gtgcctggcc gacggtggca ggcttggcgc cgcggcgggc aagctcgagg acccggcgca
    10321 gccgtgccgg ccggatgtcg gccagagggc gggcaagagc gacggccagc agcggtagcg
    10381 cacgtcggtg cgggggaagc cgtcgctgtt cggtcagggt gacaggcacg ctcacgaggc
    10441 caccaccagg cccgccgaac tcaaccgggc gaggatggct tgcacatcct gttctgcctg
    10501 ctcgggcgga atctcgtgac gacgggcgag ttcggcggcg atgtcgtcgg gcgcgcagcc
    10561 gtcgagcagc cgccgcagca cgctcgtgcc ggtggtgttg agttgccagt agcggccggt
    10621 gtgcagctgc aacaggacgg tgccgtcgtc ggtttcggtg gtgactacgt cagggtgcag
    10681 gtgcaggggc atcgtgttcc ctaggctgtc gggcggggcg cgcggcagtg cgcagccaga
    10741 gttcgcagcc gagcagggct tccaacgcga agaccatgct caggtcgcgt tggggagcca
    10801 agaggcggtt gcgcagtgtg tcggcgtcga tgagcccgcg ctgggccagt gcggagtcgg
    10861 cgaagaggtt caggatcgag gggaggttgt cggcgagtcc ctggcgcagg tccagaccga
    10921 actcgccctt ggtggcccgg cccaggatcg ccggcggtac gatgccgcgc atcgcctcgg
    10981 ccagcagtgg tttgtagcgc cgtggatcag cgtgctcatg gggccgaacc cgcagaactg
    11041 cttcgagtac gcgctggtcg tagtagggca ggtccaggtt gacgccgacg tcggcgtaga
    11101 tccgcgccat caaccggtag tgggctgcag tggtacgcac cgcaagcagg gtctgatgct
    11161 gtccgaggtc atcactgagc ggttgggcct gatgggcggt gagcctcaac gcctggcgga
    11221 tcaggtcgac gcccgcaggg gtcatccagg attgtgcctg tacggcgtgc aggccccagc
    11281 ccatggccgg tgcccgctgc ggccggaccg tgtgaaggtt gtccgcttgg tcatgccacc
    11341 acccggccac ggttcccggg cgcagcaacc ccgtcagcgc cggacgcagt gaccagcgct
    11401 tgagcgcccg gttctgacgc agccgtcgga gcgcgagcac ggggtggtgc cgcaacagcg
    11461 gggccaggta gcccggggag ggctggaaca gttcatcgcc gccgtggcct gccagatgcc
    11521 gacgagagcc ccgttgggcc agcagttgcg cgttgtggcg caagcgggcc gccgcgcgca
    11581 tggtgagcat gggctgttcg gcgtcgaccg ggatgctctc ggtgtcgaag atcgacggaa
    11641 gctcgcgctg tgcgaccacg aggtgttcgg cacggtccag tgcctgtatg gcctggcccg
    11701 cgaaatctgc gtcatcgttg gccgcatcgg cctcggccca gcgcaacgtc aacaaggccg
    11761 gtgtgtggcg ggcagccaga aaacacagcg acgtcgaatc cataccgccg gacagatcag
    11821 cactgacacg cccctgggcc ggggcacgat cctgtaccgc tccagtgagc gcctctcgca
    11881 ccccggctgc gccgtcgcgc aacgacagat gcggcgcagg agggttccac cacactttct
    11941 cgtcggcctg atcccgggtc cacaccaggc accgctcggg cgccagtgac gagattcccg
    12001 cccagagaca ccgctcgctc agaggaggcg ccagagcaag gccgctggcc agccgcacgg
    12061 ccagggattg ctcgtcgacc acggcgccga ccatctcggc aagcacatgg gcccggtcgg
    12121 acgccacgtg tacgccgtcg atacgcgtgt agaagatccg gctcagcccg ctgatgctgc
    12181 cctgcgcacg tacctgccca tccaccgacg ccatcagatg ggcggagccc gggagcgctg
    12241 aggccagttt gtccacgtcc gcgacggtcg tgaccgccgc cgtcagttcg gtgagccgct
    12301 cctggctgat cgggcagtcg ccgatcaccg ctacgcgtac cgggcccgcc gtggccaccg
    12361 tgatccggtc gtccgaccag gaacccacca gccatggtcg acccgatacg tgtgaaacca
    12421 cctgcggtga tgcgaacgac atccgcgtcc gcatcaccgc agcggcggtc gtgtccggca
    12481 ggatcacaaa cgccggcatc gtcgatcagg tgtagatgcc gaagatcgag tcgagccgcc
    12541 agccgccgaa cccgagcgtg tcttcgctga actcgccgac ctcgaccagc atcggaggaa
    12601 cgtacatttc ggcctgcgtt tcggccttct gctcttccac agaacctcct tcggaacgtc
    12661 aacttccgtg tgcaggctac aagttggcca gtccgcgatc aaccgttcat cgaacaactg
    12721 aagtgacctc caggagctcc gcaccggcgc tcaccttgcg gaaccggccg tgtaaccctc
    12781 gtcacgctct gtgtcaggcg acacgtcggc gcgccacggt taccgtcggg tcatgagtat
    12841 tcgcgccgtg gtctgggacg tcgacgacac cctcttcgac tacaccaccg ccgaccgcct
    12901 cggcatgcgc acccacctga cggccgaagg cctgctcgac gactacgaca ccgtcgagca
    12961 ggccatcacc cgctggcggg agatcaccga cgcgcaatgg gcgcgcttcg cggccggtga
    13021 ggccaccttc gaggaccagc ggcgcgaccg cgtacgggtg ttcctcggcc aggacctcac
    13081 cgacgccgag gccgacgcgt ggttcaggcg gtaccgcgcc cactacgagg cggtctgggc
    13141 cctcttcccg gacgtcctgc ccgtcctcga cgccctcgcc gccagccacc ggcacgccgt
    13201 gctgtccaac tccagcatcc acgtccagga ccgcaagctg cgcgtcctcg gcgtccacga
    13261 ccgcttcgag agcatcctgt gcgcggccga gctcggcgtc tcgaaacccg aggccggggc
    13321 gttcctggcg gcctgcgccg ccctcgacct gtcgccgcac caggtcgcct acgtcggcga
    13381 ccacccggag atcgacggac ggggtgccgc cgacgccggg ctgctgtcgg tgtggatcga
    13441 ccgcgggggc gcgtatgcca cgatcgaccc gcccgtcggg ccgcaccgca tcgcctccct
    13501 cgccgaactg ccgtctttgc tcggctcgga tagtcgtttt ggagccccgt ccaccttcag
    13561 gtaatgttct tcctgcgccg cggggagcgg gccggaaggc aggatcccca ggcgcactac
    13621 tagaacaaga tcccctccag ggcttgcgtt ccagtggcct atggtgtaat tggcagcacg
    13681 actgattctg gttcagttag tcttggttcg agtccaggta ggccagctcg cagagctcat
    13741 ctgcaccagc ggattccgat ccgcaagccc ccgttgtgta gcggcctagc acgctgccct
    13801 ctcaaggcag tagcgccggt tcgaatccgg tcgggggtac tggttccgaa agatcgacga
    13861 tcatttcggg actgctaggg cccccgttgt gtagcggcct agcacgccgc cctctcaagg
    13921 cggtagcgcc ggttcgaatc cggtcggggg tactgactgg tctaaaccac attggtctat
    13981 ggtgtaattg gcagcacgac tgattctggt tcagttagtc ttggttcgag tccaggtaga
    14041 ccagctcgga cctgcggaaa cgcagagtcc aggcccccgt tgtgtagcgg cctagcacgc
    14101 cgccctctca aggcggtagc gccggttcga atccggtcgg gggtacacac agggaaggcc
    14161 ctccacttcg gtggggggcc tttttcgtac gtccctcacg ggcgcgggga actgcgaaca
    14221 accaccgacg gcccgcacgg gacgacgaaa ccgtccctgt catggcgctc ggccggggaa
    14281 agcctgccgc ggcgttgagg ccgaccctcc ccgaacatgt tcagccggtg cgccgcaacg
    14341 cctcggagag gcgccctgcc gcatcgatca cagcctgcgc gtgcatccgg cccgggtgcc
    14401 gcgtcagccg ctcgatgggc ccggacaccg acaccgcggc gaccacacgg ttggaagggc
    14461 cccgcaccgg cgcggagacc gacgcgaccc ccggctcgcg ctcgccgatc gactgggccc
    14521 agccccggcg acgtacgccc gacagggccg tcgctgtgaa gcgcgcgccc tggaggccgc
    14581 ggtgcagccg ctccggctcc tcccaggcca tcaggatctg cgccgacgag ccggccttca
    14641 tcgtgagcgt cgagccgacc gggaccgtgt cccgcaggcc ggacagacgc tccgccgcgg
    14701 cgacgcagat gcgcatgtcg ccctggcgac ggtagagctg cgcgctctcg cccgtgacgt
    14761 cacggaggtg ggtgagcacc gggcccgcgg tggcgaggag acggtcctca cccgcggccg
    14821 cggccagttc tgccaggcga gggccgagaa tgaaacggcc ctgcatgtcg cgcgccacca
    14881 tgcggtggtg ttccagcgcc acggccaggc ggtgggccgt gggtcgtgcc agtccggtgg
    14941 cgccgaccag gcccgcgagg gtggccggac cggactccag agcgctcagg acgagggccg
    15001 ccttgtccag aacgccgacg ccgctactgt tgtccatgaa acgatactcg cgtctcactc
    15061 tgtgaaacgc aagttcaaat tctcgtggaa cccgccactc tggaagacac gaagtcacag
    15121 cggcccgtga cgtacaggcc tggcggcggt tgcccggaaa cgcaggggcg cgggcccgcc
    15181 tcttcaagat ctctagttgg gtcggcggat cgtcgtcgac cggagggaac agcgatgggt
    15241 aggacactcg cggagaaagt ctgggacgac catgtcgtcc ggcgcgcgga gggcgagccc
    15301 gaccttctct tcatcgatct gcacctgctg cacgaggtga ccagcccgca ggccttcgac
    15361 ggcctgcgca agagcggccg caaggtccgg cgcctcgacc tcaccatcgc gaccgaggac
    15421 cacaacaccc ccaccctcga catcgacaag ccgatcgcgg acccggtctc ccggatccag
    15481 ctggagacgc tgcgcaagaa cgccgccgac ttcggcgtgc ggctgcaccc gctgggcgac
    15541 gtcgagcagg gcgtcgtgca cgtcgtcggc ccgcagctgg gcctgaccca gccgggcacc
    15601 accgtcgtct gcggcgactc ccacacctcc acgcacggtg ccttcggcgc tctggcgttc
    15661 ggcatcggca cctcccaggt ggagcacgtg ctggccaccc agacgctgcc gatgtcccgc
    15721 ccgaagacca tggcgatcac cgtcgacggc gaactgcccg agggtgtcac ggccaaggac
    15781 ctgatcctgg cgatcatcgc ccggatcggc accggcggcg gccagggcta cgtcctggag
    15841 taccgcggcg aggccatcga gaagctgtcg atggaagcgc gcatgaccat ctgcaacatg
    15901 tcgatcgagg ccggcgcccg cgcgggcatg atcgccccgg acgagaccac cttcgcgtac
    15961 ctcaagggcc gtccgcacgc ccccgagggc gcggagtggg acgcggccgt cgagtactgg
    16021 aagacgctca ggacggacga ggacgccgag ttcgacgccg aggtcgtcat cgacgccgcc
    16081 gaactgtcgc cgttcgtcac ctggggcacc aaccccggcc agggcgcacc gctttcggcg
    16141 tccgtccccg accccgcttc gtacgaagac gcatcggagc gctacgccgc cgaaaaggcc
    16201 ctggaataca tggggttgga ggccggccag ccgctgcgct ccatcaaggt ggacaccgtc
    16261 ttcgtaggct cctgcaccaa cggccgcatc gaggacctgc gcgccgccgc cgagctgatc
    16321 aagggccgca aagtcgccga cggcgtacgg atgctggtcg tcccgggctc cgcgcgggtg
    16381 ggtctccagg ccgtctccga ggggctggac gtcgtcttca aggacgccgg cgccgagtgg
    16441 cggcacgcgg gctgctcgat gtgtctgggc atgaaccccg accagctcgc cccgggggag
    16501 cgctccgcgt ccacctccaa ccgcaacttc gagggccggc agggcaaggg cggtcgtacg
    16561 cacctggtgt cgccgcaggt cgcggccgcc accgccgtcc ttggccacct ggcctccccg
    16621 gccgacctgg ccgacgccga cacccgtacg cccgctggag tctgagaatc atggaagcct
    16681 tcaccaccca caccggccgg gccgttccgc tgcgccgcag caacgtcgac accgaccaga
    16741 tcatccccgc ccactggctc aagaaggtca cgcgggacgg gttcgaggac gggctgttcg
    16801 aggcctggcg caaggacgcg tcgttcgtgc tcaaccagcc cgagcggcag ggcgcgaccg
    16861 tcctggtcgc cggccccgac ttcggcaccg gctcgtcccg cgagcacgcc gtctgggcgc
    16921 ttcagaactt cggcttcaag gccgtgatct cctcccgctt cgccgacatc ttccggggca
    16981 actcgctcaa gaacggcctg ctcacggtcg ttctggagca gaagatcgtg gacgcgctgt
    17041 gggagctcac cgagaaggac ccgcaggccg agatcaccgt cgacctggtc gcccgcgagg
    17101 tccgcgccga gggcatcacc gcctccttcg agctggacga gaacgcccgc tggcggctgc
    17161 tgaacggcct cgacgacatc tcgatcaccc tccagaacga ggcggacatc gccgcgtacg
    17221 aggcgaagcg cccgtcgttc aagccgcgga cgctgccggt ctgatccgga gcacgacccg
    17281 ccgcccctga acaaggcgac tttcggccac cgcaacaccc ctctgtaccc ctgatcagcc
    17341 cgatcggggg tacagccttt tctgcacccg aacggccctg cccaccctga acccggcagt
    17401 caacttccca cgttaagccg gtggttgttg gggtacgcga gatgtacagc cgtgacttcc
    17461 gtgtgcgccc ggaagaccgt ttgaggcggc agttgtcccc tgcgcaggcg acaactcgcc
    17521 ccagatggca caatctgtgc atggaacacg acggccaact cgagctctat acggcagtcg
    17581 cgggccaact caaggaagcg cacgcaaggg tgcgcgcact gcaagtcccg gagggcgtac
    17641 ggatggcgct gacccggaag ctgctggtca ttacggccgc ggccaagcac gatctcgccg
    17701 acgcggcaag gcggctggat cggttcaccg cggacctcga cgagggacgt ctccccgacg
    17761 aggaacgctg aaccggacga caccgccgag ttcgttgcgg cacaagggtg ataagcccgt
    17821 ttcgtgtttg atttgcggta tatatctgcc taacgtgcga aaaagcttga acactttcgt
    17881 tctggcgatg tctccgaagg ggaagacgtg aacaaggcgc agctcgtaga agcgattgcc
    17941 gacaagatgg gcggccgaca gcaggccgcc gatgctgtcg accatgtact ggacgccatc
    18001 gtccgcgcgg tcgtcgctgg tgagagggtc tccgtcaccg gcttcggttc cttcgaaaag
    18061 gtcgaccgtc cggcccgcta cgcccgtaac ccccagacgg gcgagcgggt tcgggtcaag
    18121 aagacctccg ttccgcgctt ccgcgcgggc cagggcttca aggacctggt cagcggctcg
    18181 aagaagctgc cgcgcggcgg cgaggtctcc gtcaagaagg ctccgaaggg cagcctgacc
    18241 ggcggcgccg gcgcgacggt caagaaggcc gccgctaaga aggcgaccgc caagacggcc
    18301 gccgcgaaga agacaacggc caagaaggct ccggcgaaga aggccaccac caagacggcg
    18361 gccgcgaaga agaccacggc caagaaggct ccggccaaga ccacgacggc caagaccacc
    18421 gccgcgaaga agaccaccgc caagaaggca ccggcgaaga aggcgaccgc caagaaggcg
    18481 cccgccaaga agtcgacggc gcgcaagacc accgcgaaga agaccaccgc ccgcaagaag
    18541 taggggcgct ggggcactca cgcgccgggc cggactccgt acggagtccg gcccgcggtg
    18601 tgttcaggga gtggtcagag ggtctggagg gtcaccagag tgatccggaa gtcctcctcc
    18661 gggccttcca cctcgatccg cacccgctgt cccgggcgca gcagcctcaa gccgcccgcg
    18721 tcgaacgccg ccgcgtcgaa gggcaccggg gtgccgtcgt ccaggagcac ctgcccgctg
    18781 cggctttcgg ggtcgtacgt gtacgcggtc gcctgcatgg ccgcagccta ctgcccgggt
    18841 atcagcaacc gcgcggcggc cgcggccgta tgagggccga ctcccagggc cagcgcggtg
    18901 cgcaggtcgt cgccggtgtc cacgtcctgg cgtacggaat ccacggcggt gagcgacagt
    18961 tccacggccc cggacgctcg gtgccgggcc cgggaatcga taccgaaagc cggggacaat
    19021 tgccggcccg gggcggcggc cagcagagtc gtaccgattg cggccgcgtc cgggagaaaa
    19081 gcgcgcggga attgagcggc gccgtcgagt acccgggcca attccggcgg gcgcagcgcc
    19141 ggcaggtcgg cgttgagcgc ggccaccggg ctttcgggac gtgcggaccg tacggctccc
    19201 gccgcgtgtg cgagggcggc gttgaggccg cttcgcggct cgtcggggat gatcgcggcg
    19261 cccagtgcgg ccagctcgcg gccggcccgg gcgtcgtccg tgacgactgc cacatcccgt
    19321 accgccgggc acgccagcgc ggccgccacc gtgtcctgcg cgaaggcgag cgccaggtcc
    19381 ggccgcagcc cgtcgtcagc ggtgtccgca agcctgctct tggcctgggc caggggcttc
    19441 aggggtacga ccaaggtcca ctgcacagat gttccgtccc tctcttgtcg cggtcattgt
    19501 cacccggggc cgacggcgcc cggcgtgtcg gggcgtacgg tgttctcgac agaccggcgg
    19561 cctggggcga cacttgtgcg gccccccgtg gcccccgatc aggcccaaga ggaaggtgtc
    19621 cgcgtgcccc gccgcagaat cggcttctgg taccgcttcg ccgcggtgat ctgcaaaccg
    19681 ccgctggtgg ttctgctcag gcgggactgg cgaggaatgg agcacattcc ggccgagggc
    19741 ggatttatca ccgcggtgaa ccataattcg catatcgacc ccttcgctta cgcgcacttt
    19801 cagtacaaca ccgggcgcgt cccgcgattc ctcgcgaaga gcgggctttt caacaaggga
    19861 ttcgtcggcg ccgcgatgcg cggcaccggg cagattcccg tctaccgcga gagcacggac
    19921 gcgctgagtg ccttccgggc cgcgatcgaa gccgtggacc gcggggaatg cgtcgccttc
    19981 tatcccgagg gcaccctcac ccgcgacccg gcgggctggc ccatgaccgg caagaccggg
    20041 gccgcccgcg tcgccctcca gaccaagtgc ccggtgatcc ccgtcgccca gtggggctgc
    20101 aacgaactcc tgccgccgta cgagaagaag ccgcaccttc tgccgcgcaa gacgcaccgc
    20161 gtgctcgccg gaccgccggt ggacctcacg cggttctacg accaggagat gaccacggag
    20221 ctcctgaagg aggccaccga ggtcatcatg gccgccatca cccggcagct tgaggagatc
    20281 cgcggcgaga aggcgcccga gatgccctac gacccgcgcc gggagcggat cgaacagcgg
    20341 cgccgcaccc aggcgcagac acagcggggc acacagcagg cggcatcgca ggtgcagtcg
    20401 gcacagccgg cacagtcggc acaggaagag gggctgggca agtgagcaag ccggtcaagg
    20461 cggcggtcct gagcgccggt tcgtggggca cggccttcgg catggtgctc gccgacgccg
    20521 ggtgcgaggt caccctgtgg gggcgccgcc ctcaggtcgt ggaggcgatc aactccaccc
    20581 gcaccaatcc cgactacttc ccgggcgtcg agctcccgga gaacgtgcgg gccaccacgg
    20641 atcccgcgga agcggccgcg gacgcggact tcacggtcct ctcggtcccc tcgcagaccc
    20701 tgcgcggcaa cctcgccgac tgggccccgc tgctggcccc cggcacggtc ctcgtgtcgc
    20761 tgatgaaggg cgtcgaactc ggctccgcga tgcgcatgag cgaggtcatc gacgacgtcg
    20821 ccaaggtcgg cccggaccgc atcgccgtgg tcaccggacc caacctggcc cgcgagatcg
    20881 ccgcgcggat gccggccgcc gccgtggtcg cctgcaccga cgaggccgtc gcccagcggc
    20941 tccaggtcgc ctgccacacg ccgtacttcc gcccgtacac caacaccgac gtcgtcggct
    21001 gtgaactcgg cggcgcggtc aagaacgtca tcggcctggc cgtcggcatc gcggacggca
    21061 tggggctcgg cgacaacgcc aagggctcgc tcatcacccg cggcctcgcc gagaccaccc
    21121 ggctcggcat cgccctcggc gccgacccgc tgaccttctc cggactcgcg ggcctgggcg
    21181 acctggtggc gacctgttcc tcgccgctgt cccgcaacca caccttcggc accaacctcg
    21241 gcaagggcat gacgctccag gagaccatcg cggtcaccaa gcagaccgcc gagggcgtca
    21301 agtcctgcga atcggtgctg gatctggccc gccggcacgg cgtcgacatg cccatcacgg
    21361 agacggtcgt cggcatcgtg cacgagggca agcctccggt ggtggctctc aaggagctga
    21421 tgtcgcgcag cgcgaagccg gaacgacgct gagcgacgcg ggtccggggg cgctgtatcc
    21481 cggccttacc aacgggtact ctcaacgcga tatgagcacc gagaacctcc cccagagccc
    21541 cgagcagccg tctcgtaagc cgcgtgtggc cgtcgtgttc ggcgggcgca gctccgaaca
    21601 cgggatctcc gtggtcaccg ccggcgccgt cctcaaggcc atcgaccgga cgaagtacga
    21661 cgtcctgccg atcggcatca cccaggacgg ccgctgggcg ctcacggcgg acgaaccgga
    21721 gcggatggcg atcatcgacc ggcgccagcc gagcgtcgac ctgctcgccg agtccggcga
    21781 gggcggagtg atcctcccgg tcgaccccgc cagccgcgaa gtcgtctaca gcgagccggg
    21841 atcggtcccc aaggcgctcg gcgaggtcga cgtggtcttc ccggtgctgc acggccccta
    21901 cggcgaggac ggcacactcc agggcctcct ggagctctcc ggcgtcccgt acgtgggctc
    21961 gggcgtgctc gcctcggccg tgggccagga caaggagtac atgaagcggg tgttcacctc
    22021 gttcgggctg aaggtgggcc cgtacctggt gatccggccc cgtgagtggc agcaggacga
    22081 gccggccgcc cgcaagaaga tcgtcgactt cgccggggag cacggctggc ccctgttcgt
    22141 gaagcccgcg cgcgccggtt cgtcgatcgg catcaccaag gtcgacggcc tctccggcct
    22201 cgacgaggcg atcgccgagg cccagcggca cgacccgaag atcctcgtgg aggccgcgct
    22261 gcgcggccgc gagatcgagt gcggcgtcct ggagttcgag gacggccccc gggcctccgc
    22321 ccccgccgag atcccctcgc cggatgcgca cgcgtactac gacttcgagg ccaagtacat
    22381 cgactccacg ccggggatcg tgccggcgcc cctgacgccc gaggagacgg ccgaggtcca
    22441 gcgcctggcg gtcgacgcct tcgaggcggc ctcctgcgag ggcctggtcc gcgcggact
//
