LOCUS       NZ_CP023694            24673 bp    DNA     linear   CON 13-JUL-2024
DEFINITION  Streptomyces coeruleorubidus strain ATCC 13740 chromosome, complete
            genome.
ACCESSION   NZ_CP023694
VERSION     NZ_CP023694.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces coeruleorubidus
  ORGANISM  Streptomyces coeruleorubidus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 9335698)
  AUTHORS   Lee,N. and Cho,B.-K.
  TITLE     Direct Submission
  JOURNAL   Submitted (27-SEP-2017) Biological Science, KAIST, 291 Daehak-ro,
            Daejeon 34141, South Korea
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 2.3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 50X
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_008705135.1-RS_2024_04_23
            Annotation Date                   :: 04/23/2024 03:16:00
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,499
            CDSs (total)                      :: 8,405
            Genes (coding)                    :: 8,179
            CDSs (with protein)               :: 8,179
            Genes (RNA)                       :: 94
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 73
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 229
            CDSs (without protein)            :: 226
            Pseudo Genes (ambiguous residues) :: 0 of 229
            Pseudo Genes (frameshifted)       :: 96 of 229
            Pseudo Genes (incomplete)         :: 175 of 229
            Pseudo Genes (internal stop)      :: 12 of 229
            Pseudo Genes (multiple problems)  :: 53 of 229
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 14:54:21
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5655140
            Orig. end                         :: 5679813
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP023694.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria available from Korean Collection for Type Cultures.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..24673
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="18"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..24673
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24673
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:14673](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..14673)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            1087..2346
                     /db_xref="GeneID:91419572"
                     /locus_tag="CP976_RS26290"
                     /old_locus_tag="CP976_26300"
     CDS             1087..2346
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (125-383). E-value: 6e-26.
                     Score: 83.5. Matches aSDomain:
                     nrpspksdomains_CP976_RS26290_Abhydrolase_1.1"
                     /codon_start=1
                     /db_xref="GeneID:91419572"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thioesterase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020135773.1"
                     /locus_tag="CP976_RS26290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_26300"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_150482545.1"
                     /sec_met_domain="PF00561 (E-value: 3.3e-18, bitscore: 65.2,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 2.1e-22, bitscore:
                     79.8, seeds: 455, tool: rule-based-clusters)"
                     /sec_met_domain="Thioesterase (E-value: 7.6e-07, bitscore:
                     28.5, seeds: 16, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSESSAEVVANAATAAVAASAAGAAGGWRRATGIAGVAIGVVAAG
                     AAAGVALERMTVGRGMRQKARLALDSAGPYGSLRGMPGKAFADDGTELYYEVDDLDPEA
                     APAALGPRRRRLFGRKAPAPVTVVFSHGYCLNQDSWHFQRAALRGVVRTVHWDQRSHGR
                     SGRGVAQGRDEPITIEQLGRDLKAVIDAAAPEGPIVLVGHSMGGMTVMALADQYPELVR
                     ERVVGVAFVGTSSGRLGEVNYGLPVAGVNAVRRVLPGVLKAMGQRADLVEKGRRATADL
                     FAGIIKRYSFASRDVDPAIARFAERMIESTPIDVVAEYYPAFNDHDKTEALAHFADMPV
                     LVLAGVQDLVTPSEHSEAIADLLPEAELVLVPDAGHLVMLEHPEVVTDRLADLLTRTGA
                     VPAGATVKGYGSTSSTAQPG"
     aSDomain        1462..2235
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CP976_RS26290_Abhydrolase_1.1"
                     /evalue="6.00E-26"
                     /label="CP976_RS26290_Abhydrolase_1.1"
                     /locus_tag="CP976_RS26290"
                     /protein_end="383"
                     /protein_start="125"
                     /score="83.5"
                     /tool="antismash"
                     /translation="TVVFSHGYCLNQDSWHFQRAALRGVVRTVHWDQRSHGRSGRGVAQ
                     GRDEPITIEQLGRDLKAVIDAAAPEGPIVLVGHSMGGMTVMALADQYPELVRERVVGVA
                     FVGTSSGRLGEVNYGLPVAGVNAVRRVLPGVLKAMGQRADLVEKGRRATADLFAGIIKR
                     YSFASRDVDPAIARFAERMIESTPIDVVAEYYPAFNDHDKTEALAHFADMPVLVLAGVQ
                     DLVTPSEHSEAIADLLPEAELVLVPDAGHLVMLEHP"
     CDS_motif       1666..1731
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CP976_RS26290_0001"
                     /evalue="1.60E-07"
                     /label="NRPS-te1"
                     /locus_tag="CP976_RS26290"
                     /protein_end="215"
                     /protein_start="193"
                     /score="23.8"
                     /tool="antismash"
                     /translation="PEGPIVLVGHSMGGMTVMALAD"
     gene            2312..2833
                     /db_xref="GeneID:91419573"
                     /gene="tsaE"
                     /locus_tag="CP976_RS26295"
                     /old_locus_tag="CP976_26305"
     CDS             2312..2833
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_process="GO:0006400 - tRNA modification [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91419573"
                     /gene="tsaE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010036605.1"
                     /locus_tag="CP976_RS26295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_26305"
                     /product="tRNA
                     (adenosine(37)-N6)-threonylcarbamoyltransferase complex
                     ATPase subunit type 1 TsaE"
                     /protein_id="WP_150482546.1"
                     /transl_table=11
                     /translation="MEAPAAPHNPAESGSVQIVVTSPEQMRELGRRLAKLLRAGDLVML
                     SGELGAGKTTLTRGLGEGLGVRGAVTSPTFVIARVHPSLGDGPPLLHVDAYRLSGGLDE
                     MEDLDLDVSLPESVVVVEWGEGKVEELTEDRLQVVIHRAVGDTTDEVRHMTITGVGERW
                     ASADLSVLAA"
     misc_feature    complement(2909..2919)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.1"
                     /tool="antismash"
     gene            2976..3143
                     /db_xref="GeneID:91422754"
                     /locus_tag="CP976_RS43010"
     CDS             2976..3143
                     /codon_start=1
                     /db_xref="GeneID:91422754"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010036604.1"
                     /locus_tag="CP976_RS43010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_167537420.1"
                     /transl_table=11
                     /translation="MSATESKGQPLPFAVAGVSMRDLLAAGEAAALISTPPRAPEPERT
                     EPLADHREAA"
     gene            complement(3864..4421)
                     /db_xref="GeneID:91419574"
                     /locus_tag="CP976_RS26300"
                     /old_locus_tag="CP976_26310"
     CDS             complement(3864..4421)
                     /codon_start=1
                     /db_xref="GeneID:91419574"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010036602.1"
                     /locus_tag="CP976_RS26300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_26310"
                     /product="hypothetical protein"
                     /protein_id="WP_150482547.1"
                     /transl_table=11
                     /translation="MALSSSGIVAGLTAAALATVGYLAHQASQTLPAGLGRSQAGAAPA
                     AGVSKAPPRARKDPAALPGDSGMGARVVYSLGGDRVWLVGEDETVTRTFGVHPSAVDPA
                     PGNYLVTSRSNAITGSDGVPIEHVVRFTSVDGVVIGFSAAVTDPTAAPAPNVRTGGIRE
                     SREDGEAMWTFATIGRKVVVVR"
     gene            4559..5212
                     /db_xref="GeneID:91419575"
                     /gene="tsaB"
                     /locus_tag="CP976_RS26305"
                     /old_locus_tag="CP976_26315"
     CDS             4559..5212
                     /EC_number="2.3.1.234"
                     /GO_function="GO:0003725 - double-stranded RNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006400 - tRNA modification [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91419575"
                     /gene="tsaB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019527945.1"
                     /locus_tag="CP976_RS26305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_26315"
                     /product="tRNA
                     (adenosine(37)-N6)-threonylcarbamoyltransferase complex
                     dimerization subunit type 1 TsaB"
                     /protein_id="WP_150482548.1"
                     /transl_table=11
                     /translation="MLLLALDTATPAVTVALHDGRDVIASSSQVDARRHGELLLPAIDR
                     VLAGAGLKLDAVTGIVAGIGPGPYTGLRVGLMTAETFGLALGVPVHGVCTLDGLAYAAD
                     LEGPFVVATDARRKEVYWARYADSRTRVTDPAVDRPADIAEQVAGLPAVGAGALLYPDT
                     FPQAHEPEHVSAAALARLAAERLAAGEEFPAPRPLYLRRPDAQVPKNYKVVTPK"
     gene            5242..5739
                     /db_xref="GeneID:91419576"
                     /gene="rimI"
                     /locus_tag="CP976_RS26310"
                     /old_locus_tag="CP976_26320"
     CDS             5242..5739
                     /EC_number="2.3.1.266"
                     /GO_function="GO:0008999 -
                     peptide-alanine-alpha-N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_process="GO:0036211 - protein modification process
                     [Evidence IEA]"
                     /GO_process="GO:0042254 - ribosome biogenesis [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91419576"
                     /gene="rimI"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009300602.1"
                     /locus_tag="CP976_RS26310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_26320"
                     /product="ribosomal protein S18-alanine
                     N-acetyltransferase"
                     /protein_id="WP_150485514.1"
                     /transl_table=11
                     /translation="MRWWDIDPVLELERALFPDDAWSRGMFWSELAHARGPEASRKYLV
                     AEEGERIVGYAGVASSGEQADIQTIAVTREYWGTGLGGRLLTELLRAATAFECAEVMLE
                     CRVDNIRAQKLYERFGFEAIGFRRGYYQPGNVDALVMRLTTKPDSGSAAGSAPVQGTQI
                     ND"
     gene            5732..6838
                     /db_xref="GeneID:91419577"
                     /gene="tsaD"
                     /locus_tag="CP976_RS26315"
                     /old_locus_tag="CP976_26325"
     CDS             5732..6838
                     /EC_number="2.3.1.234"
                     /GO_process="GO:0006400 - tRNA modification [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91419577"
                     /gene="tsaD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011029841.1"
                     /locus_tag="CP976_RS26315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_26325"
                     /product="tRNA
                     (adenosine(37)-N6)-threonylcarbamoyltransferase complex
                     transferase subunit TsaD"
                     /protein_id="WP_150482549.1"
                     /transl_table=11
                     /translation="MTDSRDEPLVLGIETSCDETGVGIVRGTTLLADAVASSVDEHARF
                     GGVVPEVASRAHLEAMVPTIDRALKDAGVSARDLDGIAVTAGPGLAGALLVGVSAAKAY
                     AYALGKPLYGVNHLASHICVDQLEHGALPEPTMALLVSGGHSSLLLSSDITSDVRPMGA
                     TIDDAAGEAFDKIARVLNLGFPGGPVIDRYAREGDPGAIAFPRGLTGPRDPAYDFSFSG
                     LKTAVARWIEAKRAAGEEVPVRDVAASFQEAVVDVLTRKAVRACKDEGVDHLMIGGGVA
                     ANSRLRALAQERCEAAGIRLRVPRPKLCTDNGAMVAALGAEMVARNRPASSWDLPADSS
                     LPVTEPHVPGHRHDHDHVHEISKENLYS"
     gene            6835..7092
                     /db_xref="GeneID:91419578"
                     /locus_tag="CP976_RS26320"
                     /old_locus_tag="CP976_26330"
     CDS             6835..7092
                     /codon_start=1
                     /db_xref="GeneID:91419578"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010986381.1"
                     /locus_tag="CP976_RS26320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_26330"
                     /product="hypothetical protein"
                     /protein_id="WP_150482550.1"
                     /transl_table=11
                     /translation="MTVAMMWEARAVPGRGEDLLAWARAQELPRAPLRRETLRAPQDRV
                     LVITWWDAPYDAELPELPEPEGELVTRAVHRWRFESVGGA"
     gene            complement(7123..8082)
                     /db_xref="GeneID:91419579"
                     /locus_tag="CP976_RS26325"
                     /old_locus_tag="CP976_26335"
     CDS             complement(7123..8082)
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91419579"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1083: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015659220.1"
                     /locus_tag="CP976_RS26325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_26335"
                     /product="LLM class flavin-dependent oxidoreductase"
                     /protein_id="WP_150482551.1"
                     /transl_table=11
                     /translation="MTLSVMFPVMPERIEDLVRFARHVADGPCHRLWMGQTLTYETFQA
                     LAYLAGAGVRLPVGTGVALTPLRHPYEAALQARTVAQLMGHPVVAAFGTGGQEFAQDML
                     GAPYARPATAVAEYLTVARHTLAGEYFEFHGEYHRVSSGLYPVRHPGVELGAGVLRPGM
                     ARKAGATADVAVTWLTPPAYLAEVVRPALEAGARSAGRRPPRIAAVVHVAVARPGRDPR
                     RLAYLGNAGHLVTDHYVDMLRRAGLDVSADDPEKGAQALVEAGVLAYGAPARIARELEE
                     YRAAGVDEVVLSPVGVCADEGFDAALADVDDIARAVSG"
     gene            complement(8079..10004)
                     /db_xref="GeneID:91419580"
                     /locus_tag="CP976_RS26330"
                     /old_locus_tag="CP976_26340"
     CDS             complement(8079..10004)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91419580"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008741466.1"
                     /locus_tag="CP976_RS26330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_26340"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_150482552.1"
                     /transl_table=11
                     /translation="MTTGDASHHDGESAEELDEQEVNRKLSRSPSYWLRLMALFWRISP
                     ARISVLALLTWAVAVVPGLQIRLTAAAVDAVTDGVTAAGGDTARDALITALAGILSLSL
                     LAHVVGAYVQYLGAVVGLQLTARISEQVMAKGTRMDLATYEDPESYDRLQRAFQESTTG
                     RAYEIFSDLVETVKNLVTLIAISAALFSWHPWAALITLLSPLPAAVVQAAYGKREFEVE
                     YDRAQDRRRAYYFQWLTTQDHTFKEIKLFGLGPHFIRRYRELVQGFYEVDRRLAMKQEG
                     WSAAAGLIGVLGATGAMALAMLSAMDTGEVGELAGFLQAIASVSAASSGMLVGLATLYQ
                     NTLFTGNLFDYLGLPESVIKGGARPFPESLRHGIEFRDVTFVYPGTDTKALDGFSCLIP
                     AGKCCALVGQNGAGKTTIVKLLTRLYEPTSGRILIDGHPIEDYDVDQLRSGIGVIFQDF
                     IKYELPARENIGFGRVEALDDEARIARAATASGAAEVVAKLDEGYDTVLGRHFEDGAQL
                     SGGQWQKVALARAFMRQAPVLVLDEPTASIDAEAEAEVFGKLREIASGATSLVIAHRFS
                     TVRIADKIVVIEDGRLAEEGTHGELMEHDGIYAYLFNLQAAGYRAEDGPDGTGDEEEQD
                     REEALR"
     gene            complement(10001..13228)
                     /db_xref="GeneID:91419581"
                     /locus_tag="CP976_RS26335"
                     /old_locus_tag="CP976_26345"
     CDS             complement(10001..13228)
                     /codon_start=1
                     /db_xref="GeneID:91419581"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.4"
                     /locus_tag="CP976_RS26335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_26345"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_150482553.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 9.6e-142,
                     bitscore: 472.2, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 5.1e-13,
                     bitscore: 48.5, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.5e-34, bitscore:
                     118.9, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAPPSPYRHAGFFLLRTPALPASTFHRLTDDAALSALSGTPRVR
                     RALEVASPSLGAALREGHEPGDGKRGRRIRSGLLRYLTRMSTRPTPYGAFAAVTMGEFG
                     PRTTARLGAGAVGRQRIRADMGWLMLFVREAQQRVGAADGLALVWNALAHPSGERIVLP
                     QADAYGQGEGKAARILDTEAVRLVRERTRGPVPCPYGEVVAELSAAFPDAPAERLNALI
                     GELLDLGFLLSDLRPPLTLPHPEHHVAERLAKTAGTTAADLARELDGVAGAARHAETSD
                     TADELVALRAAQRALVPAHRGETFHLDAAADLRGGGMTAAVGEAAADAVGVLARLADAL
                     PGPDRHLAAYAEAFMERYGTGALVPLTDVLSPLTGLDAPAGYLQPPPAAPPEPGPEPVT
                     RAYERVLAEQLGGTPPGGAVELSDALEDRLVRAALRDRAEDRAAHGHGRHQGAGAGTPV
                     AAVDVYLQVHAAGADAIDRGEWRLVLNDDGLAPGGCTFGRFFDLFDDAQREGLRRYARH
                     RQELAPHAVVAELSYVPAHGRGANVAVRPLHHDFEIPVNVPPTVPEERVIALDDLYVAA
                     DHTGLFLWSRRLGREVIVAEGHMLTPAAAPNVCRFLTDVSRLRRRTVGGFTWAGLEGGP
                     YLPRVVRGRVVLRAAEWTLTAGQLAAARPTDSGARAAEPAPGATDTPETRDALARWRAQ
                     WRVPRYVYLVEHDNRLLLDLDRPGCRTELLRELRTSSAVRLQEMLPGFDGLWLRDESGD
                     AYVSELVVPLLPAGQAAQPAAPDRTSPRHAPAAVARPRHLPGDRWSCLKLYSCFDRHDE
                     ILAGPLRALADALRRDGRADRWFFIRYADPRPHLRIRFRAPGQATPAEHGALLTELLAF
                     GRDMVRRGLAGDLEIASYEPEVVRYGGPRVHDAIERLFEAGSDTALQVVDRMWGGELDM
                     RAEFVAVAVLDALYDRWGLDVRARFAVAPGAAGAEETAARSLYREHRDYLGELLAPWDL
                     RPHPRGRADHAALAPLLVTQAAAAAGAGRAVRDAAARGELWGTEEDVLASLAHMTVNRL
                     LPVDLSREERIYGVWKNVLRTIGGRPA"
     aSDomain        complement(12515..12760)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_CP976_RS26335_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="1.70E-15"
                     /identifier="RREFam001.1"
                     /label="CP976_RS26335"
                     /locus_tag="CP976_RS26335"
                     /protein_end="238"
                     /protein_start="156"
                     /score="48.5"
                     /tool="antismash"
                     /translation="GERIVLPQADAYGQGEGKAARILDTEAVRLVRERTRGPVPCPYGE
                     VVAELSAAFPDAPAERLNALIGELLDLGFLLSDLRPP"
     gene            complement(13309..14673)
                     /db_xref="GeneID:91419582"
                     /locus_tag="CP976_RS26340"
                     /old_locus_tag="CP976_26350"
     CDS             complement(13309..14673)
                     /codon_start=1
                     /db_xref="GeneID:91419582"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.4"
                     /locus_tag="CP976_RS26340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_26350"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_150482554.1"
                     /sec_met_domain="LANC_like (E-value: 7.6e-42, bitscore:
                     142.3, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPTHTRTSPSDRTSGPHWGRVALPAPLTARARQAADRVADALAGP
                     HLLPELAARAAAQSDDAVWDGSSLSHGHAGLALLHLYAARAGGGRAAYDRAFAFLRAAF
                     EHTETEPVPEPGMFGGTSGLALALADFAADEPRFRPSMDRLHERLADQVLAVDRPSGAV
                     ADHDYDAINGAAGVLAHQCTVDSPSPRMREATDRTLDFLLRLSTGDGPPYALAVAPRWY
                     PLDEYRADYPHGYLNLGLSHGVPGVAGALAAALRAGHRAPETRTALRGLVDWLLAVRLT
                     DAQGPLWARGVPLDANGRTVPNDALPHAHDQLAWCYGTAGVAVALLRAAEALGDDAAGS
                     AAADAFDAVLRRGPGRGTVLSPTLCHGMAGLVAVCAEFAASGRSPNAEAALPSLVGELL
                     AYAEDDRPLLFADQDVPGNFVDDPGLLTGAAGVALTLFAVTGRDRPRWFTAFFLS"
     gene            complement(14904..15077)
                     /db_xref="GeneID:91422755"
                     /locus_tag="CP976_RS43015"
     CDS             complement(14904..15077)
                     /codon_start=1
                     /db_xref="GeneID:91422755"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CP976_RS43015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_167537421.1"
                     /transl_table=11
                     /translation="MAVAKDPFALDARVSGSGGDAVVQGTPTITVSIVTKVSAKKCTKI
                     KTCTCKGCTFKC"
     CDS_motif       complement(15000..15077)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MAVAKDPFALDARVSGSGGDAVVQGT"
                     /locus_tag="CP976_RS43015_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(14904..14999)
                     /prepeptide="core"
                     /locus_tag="CP976_RS43015_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="-11.60"
                     /molecular_weight="3159.9"
                     /monoisotopic_mass="3157.8"
                     /core_sequence="PTITVSIVTKVSAKKCTKIKTCTCKGCTFKC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MAVAKDPFALDARVSGSGGDAVVQGT"
                     /leader_location="[14999:15077](-)"
                     /alternative_weights="3177.9"
                     /alternative_weights="3196.0"
                     /alternative_weights="3214.0"
                     /alternative_weights="3232.0"
     misc_feature    complement(15092..15107)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.52"
                     /tool="antismash"
     misc_feature    complement(15240..15249)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.19"
                     /tool="antismash"
     gene            15384..16139
                     /db_xref="GeneID:91419583"
                     /locus_tag="CP976_RS26345"
                     /old_locus_tag="CP976_26355"
     CDS             15384..16139
                     /codon_start=1
                     /db_xref="GeneID:91419583"
                     /inference="COORDINATES: protein motif:HMM:NF015649.4"
                     /locus_tag="CP976_RS26345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_26355"
                     /product="BTAD domain-containing putative transcriptional
                     regulator"
                     /protein_id="WP_167537422.1"
                     /transl_table=11
                     /translation="MQTCEDLEIRLLSGSPALASRGGVSILPASSHAARLVAFLGVHRG
                     ERVSRDRLVDLLGLSRAADPRAALRKAVWQVNNSTDGRFLRGTRTDLGLADGVRVDYQE
                     ARERCLGLLRRGFTEVATADLPARFRAQLESEVLGEFEEDWVVACRQEWQRLRLEVLHG
                     LAEAELIRGNARAAVISAEQVVRCDPLREGAWHTLLSALLASRHRAAARQRFNELVDLL
                     RDDLGVAPMFSWEELLEDPPRAPVTGLWV"
     gene            complement(16155..18467)
                     /db_xref="GeneID:91419584"
                     /locus_tag="CP976_RS26350"
                     /old_locus_tag="CP976_26360"
     CDS             complement(16155..18467)
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91419584"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010036593.1"
                     /locus_tag="CP976_RS26350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_26360"
                     /product="glycoside hydrolase family 3 N-terminal
                     domain-containing protein"
                     /protein_id="WP_150482556.1"
                     /transl_table=11
                     /translation="MTTAPWRDPALPAAARVDDLLSRMTLEEKTAQLYGVWVGASTDGD
                     GVAPHQHDMTVDYEWDELITRGLGQLTRSFGTAPVDPALGAQALARAQRRIIEAGRFGI
                     PAIAHEECLAGFTAWQATAYPVPLAWGATWDPPLVEEMARRIGDDLRSAGVHQGLAPVL
                     DVVRDPRWGRVEETIGEDPYLVGTVGAAYVRGLESAGVVATLKHFAGYASSAGARNLAP
                     VRAGIREFADVTLPPFEMALREGGARSVMAAYTERDGVPASADPELLTGLLREEWGFTG
                     TVVADYFGIGFLQTLHRVAGTPAEAAHAALEAGIDVELPSLKCYGDPLVDAVRSGEIPE
                     ELVDRAARRVLLQKCELGLLDEDWAPEPAAPVELDSTRNRILARRLAEESVVLLDNPDG
                     LLPLAPDTRIAVIGPRAADALAMLGCYSFPSHVLTHHPGVPTGIEIPTVLDALRTELPD
                     AKVTFAPGCDVTDPDTSGFEEAVARTAEADVCVAVLGDRAGLFGRGTSGEGCDATDLAL
                     PGAQGELLDALVATGVPVVLVLLTGRPYALGRWHGRLGAVVQAFFPGEEGGPAVAGVLS
                     GRVNPSGRLPVSVPQVPGGQPWTYLQPPLGLAGEVSNLDPTPLYAFGHGRSYTTFVWED
                     GTGGEEPAEIGTDGTYDVSVTVRNTGDREGAEVVQLYLHDPVASVTRPDVRLIGYQRVA
                     AAPGEAVRVTFRFHADLSAFTDRSGRRVVEPGALELRLAASSADVRHTARLTLTGPVRV
                     LGADRRLRCETEVSELP"
     gene            18631..19695
                     /db_xref="GeneID:91419585"
                     /locus_tag="CP976_RS26355"
                     /old_locus_tag="CP976_26365"
     CDS             18631..19695
                     /codon_start=1
                     /db_xref="GeneID:91419585"
                     /gene_functions="regulatory (smcogs) SMCOG1078: LacI family
                     transcription regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010036592.1"
                     /locus_tag="CP976_RS26355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_26365"
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="WP_150482557.1"
                     /transl_table=11
                     /translation="MTSPEPVESRTQNRTQGRSAQTATLAEIAREAGVSAPTVSKVLNG
                     RADVAPATRARVEDLLRAHGYRRRRAEATRSPLIDLVFHELESAWALEVIRGVENVARD
                     AGLSVVLSESAGRLTPGRTWADQVAARRPHGVVLVLSGLDESQRALLTSRAIPFVVMDP
                     AGDPGADVPSIGATNWQGGLAATRHLVELGHRRIGAISGPTQMMCSRARVDGYRAALET
                     AGLPVDPGLIANGDFHHEAGYRLGLELLRRPDRPTAVFAGNDLQALGLYEAARELGLRI
                     PEDLSVVGFDDLPVAPLVGPPLTTVRQPLTEMAEAAAKLVLDLGREAGTPAATRVELAT
                     SLVVRSSTAAPAGG"
     misc_feature    complement(19778..19796)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 20.19"
                     /tool="antismash"
     gene            19795..21144
                     /db_xref="GeneID:91419586"
                     /locus_tag="CP976_RS26360"
                     /old_locus_tag="CP976_26370"
     CDS             19795..21144
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91419586"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010036591.1"
                     /locus_tag="CP976_RS26360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_26370"
                     /product="endo-1,4-beta-xylanase"
                     /protein_id="WP_190146878.1"
                     /transl_table=11
                     /translation="MRSLRSGLLASLLAGVVTAGSLLLAAPVSHAADVPLRDLAEAKDK
                     VMGTAVTGSKLTGTYGEIAGREFNWLTPGNAMKWGSVEPSRGSYDWAEADQIVDFAEAH
                     DQQVRGHTLLWHQQNPGWLTNGSWTRDQLSAIVQDHIATEVGRYKGRLAAWDVVNEPFN
                     EDGTYRRTLFHDTLGQDYIAQALTWARAADPGARLYINDYNVEGVNAKSTALYNLVKSL
                     KERGVPIDGVGLQAHLIVGQVPSTMQQNIQRFADLGVDVAITELDIRMQLPATQAKLTQ
                     QAADYKAVMNACVAVARCSGVTVWGFTDSDSWIPDTFPGQGAATPYDENYQPKPAYHAI
                     AEALGGTTTPPTGACSATYSVTSQWSTGYTGQVRIACSGASLSSWKANWTFGAGQRIAQ
                     AWNASCTQSGAAVSCVNASYNGSVPDGGSVTFGFNGSWSGSNPVPVVTLG"
     misc_feature    19816..19818
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(21155..21169)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.58"
                     /tool="antismash"
     misc_feature    complement(21165..21179)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.6"
                     /tool="antismash"
     misc_feature    21166..21179
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.14"
                     /tool="antismash"
     misc_feature    complement(21166..21180)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.05"
                     /tool="antismash"
     misc_feature    21167..21180
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.24"
                     /tool="antismash"
     misc_feature    complement(21168..21181)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.52"
                     /tool="antismash"
     misc_feature    complement(21199..21212)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.87"
                     /tool="antismash"
     misc_feature    21210..21223
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 17.73"
                     /tool="antismash"
     gene            21229..22272
                     /db_xref="GeneID:91419587"
                     /locus_tag="CP976_RS26365"
                     /old_locus_tag="CP976_26375"
     CDS             21229..22272
                     /GO_process="GO:0070726 - cell wall assembly [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91419587"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003998767.1"
                     /locus_tag="CP976_RS26365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_26375"
                     /product="LCP family protein"
                     /protein_id="WP_229875512.1"
                     /transl_table=11
                     /translation="MTGRDGSGDAGRAVGRRSRALRIAGFSLAGALVLGIGAAGWAYRH
                     LSDNITSVDIDNALGDNRPPKPEVTPSSSAAALPSEALNILVLGSDSRSGEENRRLGGG
                     DSSGARSDTAMVVHLDAGRTGATVVSIPRDTLVTRPSCPRPSGGSTAVAHHSMFNNAYA
                     VGGPVCAVKTVEAVTGVRMDHYIEIDFSGFAKLVDALGGVTVTTDEDIADDDSHLRLKA
                     GTHHLDGTRALALARTRHGIGDGSDLGRIGLQQKLVKALLEQIAARDLLTDPAKLYRVA
                     DAVTAGLTTDTGLDSLAELTRLGQSLKDLSASAVRTVTMPVVRAPSDPNRVVAEEPEAR
                     ELWESLR"
     misc_feature    complement(22295..22309)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.3"
                     /tool="antismash"
     misc_feature    22296..22309
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.93"
                     /tool="antismash"
     gene            22402..22758
                     /db_xref="GeneID:91419588"
                     /locus_tag="CP976_RS26370"
                     /old_locus_tag="CP976_26380"
     CDS             22402..22758
                     /codon_start=1
                     /db_xref="GeneID:91419588"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010986392.1"
                     /locus_tag="CP976_RS26370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_26380"
                     /product="YciI family protein"
                     /protein_id="WP_086600897.1"
                     /transl_table=11
                     /translation="MPRFLTLIRIDEKNAPAEGPSPELQERMGKLLEEITKAGVMLDTA
                     GLTPTADGSRVTWEDGKLSVTDGPFTESKEVIGGYSISQCKDKAEAIEWTKRFLSLHED
                     YWTITAEVRQIAEG"
     misc_feature    complement(22420..22433)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.57"
                     /tool="antismash"
     gene            22998..24221
                     /db_xref="GeneID:91419589"
                     /locus_tag="CP976_RS26375"
                     /old_locus_tag="CP976_26385"
     CDS             22998..24221
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91419589"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010036581.1"
                     /locus_tag="CP976_RS26375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_26385"
                     /product="RNA polymerase sigma factor"
                     /protein_id="WP_190146896.1"
                     /transl_table=11
                     /translation="METVFRIESPRIIAGVARVVRDVGIAEELAQDALVAALEQWPRDG
                     VPDNPGAWLMATARNRAVDLVRRRENYARKLAEIGRDLSTVSPPEEPADPDDIDDDLLR
                     LVFTACHPVLSTEARTALTLRLLGGLTTAEIARAFLVPEPTVAQRIVRAKRTLATRNIA
                     FEVPYGPDREARLGSVLDVIYLVFNEGYAATAGDDWLRPSLCEDALRLARVLSALMPKE
                     PEVHGLTALLEFQASRTAARTGPSGEPVLLKDQNRARWNRMLIGRGITALGRAEAASSG
                     TPGPYLLQAAIAACHAHAYTYEETDWSRIATLYGVLAARSPSPVVELNRAVAVSMAEGP
                     APALAIVDSLLADPALRDYHLLPSVRGDLLSRLGRTAEARAEFERAASLTRNERERELL
                     SRRAAEQT"
     misc_feature    24545..24559
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.92"
                     /tool="antismash"
ORIGIN
        1 gcgacgcccg aggaggccct cgccctgcgg gccgccgggc tgccgggccg catcatgtgc
       61 tggctgtgga cgccgggcgg gccctggcgc gaggcgatcg aggcggacct cgacgtgtcc
      121 gtcagcggga tgtgggccct ggccgaggtc accgaggcgg cccggctcgc cgggcggccc
      181 gcccgggtgc agctcaaggc cgacacgggg ctcgggcggg gcggctgcca gcccggggac
      241 gactgggccg ggctggtccg ggaggcgctg cgcgccgagg ccgaggggct cctgcgcgtc
      301 acggggctct ggtcgcactt cgcctgtgcc gacgaacccg gccatccctc catcgccgcc
      361 cagctcggcc gcttccggga gatggtcgcg tacgccgagg agcagggcgc ccgccccgag
      421 gtccggcaca tcgccaactc gccggccacg ctcacgctcc ccgagagcca cttcgacctg
      481 gtccgcaccg gcatcgccac ctacggcatc tcgcccagcc ccgagctcgg caccccggcc
      541 gacttcggac tgcgcccggt gatgacgctg tccgcctcac tcgccctggt caagcacgtg
      601 ccgggcgggc acggcgtcag ctacggccac cggtacgtga cgtccggtga gaccaccctc
      661 ggcctcgtcc cgctgggcta cgccgacggc atcccgcggc acgcctcctc ggccgggccc
      721 gtcctggtcg agggcaagtg gcgcacgatc gcggggcggg tcgccatgga ccagttcgtg
      781 gtcgacctgg gcggcgacga gcccgcgccg ggcgccgagg cggtcctctt cgggcccggc
      841 gatcgcggcg agcccaccgc cgaggactgg gcccaggcgg ccggaaccat cgcctacgag
      901 atcgtgaccc ggatcggaac gcgcgttcct cgcgtctatg tgaatgagga acaggacggg
      961 taactcgcac agaggaccgg tcacgcgaag aacaacgggc accctggcaa cacaagcacc
     1021 agtaccaggc accctgacca gcaccatgag catccacaga agcaccccgg cgaagaggag
     1081 cggtacgtga gcgagagcag cgcggaggtc gtcgcgaacg ccgccaccgc ggccgtcgcg
     1141 gcctccgccg cgggggcggc gggaggctgg cgccgggcga ccggcatcgc cggcgtcgcg
     1201 ataggcgtgg tggccgcggg cgcggccgcc ggtgtcgccc tggagcggat gacggtcggc
     1261 cggggcatgc gccagaaggc ccggctcgcc ctcgactccg cgggacccta cggctcgctg
     1321 cgcggcatgc ccggcaaggc gttcgcggac gacggcacgg agctgtacta cgaggtcgac
     1381 gacctcgacc cggaggccgc ccccgccgcc ctcggcccgc gccgccgccg gctcttcggc
     1441 cgcaaggccc ccgcccccgt caccgtcgtc ttcagccacg gctactgcct caaccaggac
     1501 tcctggcact tccagcgggc ggcgctcaga ggcgtcgtac ggaccgtcca ctgggaccag
     1561 cgcagccacg gccggtccgg gcggggcgtg gcccaggggc gggacgagcc gatcaccatc
     1621 gagcagctcg gccgcgacct caaggccgtc atcgacgcgg ccgcgcccga ggggccgata
     1681 gtgctggtcg ggcactcgat gggcggcatg acggtgatgg cgctggccga ccagtacccc
     1741 gagctggtcc gggagcgggt cgtcggggtg gccttcgtgg ggacgtcgtc ggggcggctc
     1801 ggcgaggtca actacgggct tccggtggcc ggcgtcaacg cggtgcggcg ggtgctgccc
     1861 ggcgtgctga aggcgatggg gcagcgggcc gacctggtgg agaaggggcg ccgggcgacc
     1921 gcggacctgt tcgccgggat catcaagcgg tactccttcg cctcccggga cgtcgacccg
     1981 gccatcgccc ggttcgccga gcggatgatc gagagcacgc ccatcgacgt ggtcgccgag
     2041 tactacccgg cgttcaacga ccacgacaag accgaggcgc tcgcccactt cgccgacatg
     2101 ccggtcctcg tcctggccgg ggtgcaggat ctggtcacgc cgagtgagca cagcgaggcg
     2161 atcgccgatc tgctgccgga ggccgagctg gtgctggtgc cggacgccgg gcacctggtg
     2221 atgctggaac acccggaagt ggtcaccgac cgcctcgccg acctgctcac ccgcacgggt
     2281 gccgtgcccg caggagctac cgtgaagggt tatggaagca ccagcagcac cgcacaaccc
     2341 ggctgagtcc ggatccgtcc agatcgtcgt cacgtccccc gagcagatgc gggagctggg
     2401 ccgccggctc gcgaaactgc tgcgcgcggg tgacctggtg atgctcagcg gagagctcgg
     2461 ggcgggcaag acgacactga cgcgtgggct gggcgagggg ctcggcgtgc gcggggccgt
     2521 cacctcgccg acgttcgtga tcgcccgggt gcatccctcg ctgggcgacg ggccgccgct
     2581 gctccatgtc gacgcgtacc ggctgtccgg cggtcttgac gagatggagg acctcgatct
     2641 cgacgtctcg ctgcccgagt ccgtggtcgt cgtggagtgg ggcgagggca aggtggagga
     2701 gctgaccgag gaccggctcc aggtggtcat ccaccgcgcg gtgggcgaca cgaccgacga
     2761 ggtccggcac atgacgatca ccggtgtggg ggaacgctgg gcttcggcgg acctgagcgt
     2821 gctcgcggcg tagctcccgc cgcgtggtgt tttgatgaac gttccgacaa ggcgtcggca
     2881 aaatgttgcg ttcggcgtct tgtgcgtggt cacatggtat ccagtccgta gttaggtgta
     2941 cctaactacg tccgccccgc cttcgggagg cgtccatgtc ggctacagag agcaaggggc
     3001 agccgctgcc gttcgcggtc gccggggtgt ccatgcggga cctgctggcg gcgggcgagg
     3061 cggcggcact gatctccacg ccaccgcggg ctcccgagcc ggagcgcact gagccactgg
     3121 cggaccaccg cgaagcggcc tagcggccgg ccatggcccg gtggcccggc ggcccggcgg
     3181 ccgatcaggg cctcgcggcc ttgcggcctt gcggccttgc ggccttgcgg ccttgcggcc
     3241 ttgcggcctt gcggccttgc ggccttgcgg gctgcggctt agcggacggt cacgaactgg
     3301 ggcctggcgg cccagtggct tagcggacga tcacggccca gcggcccagc ggcctggcgc
     3361 tcttgcgcct tggcgggcca ccgtggagcg gcctagcggc cgaccatgac cttgcggccc
     3421 ggtggcccgg cggcctagcg atcgaatggc cttgcggcct tgcagtccgg cggcccagtg
     3481 gcccagcgga cgatcacgac ctgggacctc gcagcccggt ggcctggcgg cccaatggcc
     3541 tggcggacga tcacggtctt gcggcccagt ggcccggcgc ccttgcgtcc tggcgggcca
     3601 ccgtggagcg gcctagcggc cgaccatgac cgtgcggccc ggtggcccgg cggcccgggg
     3661 ccgaccatgg cattgaggtc ttgcgggcta cggctgagcg gacgatcacg gccttgcggc
     3721 ctagcagtcc ggcatcccag tcgcccaggg gacgatcacg accggggcct agcagtccgg
     3781 ccgccttgca gttcggcggc ctggtggccc ggtggcaccg cgggcttgcg ccctggcgga
     3841 gcactgcgga gcggtgtcgt ggcctagcgg acgaccacga ccttgcggcc gatcgtcgcg
     3901 aaggtccaca tcgcctcgcc gtcctcgcgt gactcgcgga tgccgcccgt gcgtacgttc
     3961 ggggccggtg cggcggtcgg gtcggtgacg gccgcgctga agccgatgac cacgccgtcc
     4021 acgctggtga aacgtacgac gtgctcgatg gggacgccgt cggagccggt gatggcgttc
     4081 gagcgggacg tgaccaagta gtttcccggg gcggggtcca ccgcgctcgg gtggaccccg
     4141 aacgtacggg tgaccgtctc gtcctcgccg accagccaca cccggtcgcc gcccagggag
     4201 tacacgaccc gtgcgcccat gccggaatcg ccgggcagtg cggcggggtc cttcctggcc
     4261 cggggcggcg ccttcgagac gcccgccgcc ggtgcggcgc ccgcctgtga cctgcccaga
     4321 ccggccggga gggtctgcga cgcctggtgg gcgaggtagc cgaccgtcgc gagggccgcg
     4381 gcggtgagcc cggccacgat ccccgagctg ctgagtgcca ccggctccca cctccgtgtc
     4441 gtacgtccct gtcgcgcacg gtgcgtatgc cgcgccgtga cggtaggtga cggtagcagc
     4501 aggtgacggc ccgccaggta cgtccgacac gggccccggg gagccgtagg ctgtttgcgt
     4561 gctcttgctc gctctggata ccgccacacc cgccgtcacc gtcgcgctgc acgacggccg
     4621 ggacgtcatc gcctcgtcga gtcaggtgga cgcgcgccgg cacggggaac tgctgctgcc
     4681 cgcgatcgac cgggtgctcg ccggggccgg tctgaagctc gacgccgtca ccgggatcgt
     4741 cgccggcatc ggtccgggcc cgtacaccgg gctgcgcgtc ggactgatga ccgccgagac
     4801 cttcgggctc gcgctcggcg tccccgtgca cggcgtgtgc acgctggacg gcctcgccta
     4861 cgccgccgac ctggagggcc cgttcgtcgt ggcgaccgac gcccgccgca aggaggtgta
     4921 ctgggcgcgc tacgccgact cccgcacccg cgtcaccgac ccggccgtcg accggcccgc
     4981 cgacatcgcc gagcaggtcg cggggttgcc cgcggtcggc gcgggcgcgc tgctgtaccc
     5041 ggacaccttc ccccaggcgc acgagcccga gcacgtgtcc gccgccgcgc tagccaggct
     5101 ggccgcggag aggctggcgg cgggtgagga attccccgcg ccccggccgc tgtacctgcg
     5161 ccgccccgac gcccaggtcc ccaagaacta caaggtggtc acgcccaagt gaccgagtcc
     5221 gagacgtgtg tgctgcgcga gatgcgctgg tgggacatcg accccgtgct ggagctggag
     5281 cgtgccctgt tccccgacga cgcctggtcg cggggcatgt tctggtccga gctggcccat
     5341 gcgcgcgggc cggaggcgag ccggaagtac ctcgtggccg aggaggggga gcggatcgtc
     5401 gggtacgccg gtgtcgcctc ctccggcgag caggccgaca tccagaccat cgccgtcacc
     5461 cgggagtact gggggacggg gctgggcggc cggctcctca ccgaactgct gcgggccgcg
     5521 accgccttcg agtgcgccga agtgatgctg gagtgccggg tggacaacat ccgcgcgcag
     5581 aagctgtacg agcgcttcgg cttcgaggcc atcggcttca ggcgcggcta ctaccagccg
     5641 gggaacgtgg acgccctggt gatgcgactg accacgaaac ccgacagcgg ctccgccgcg
     5701 ggttcggctc ccgtacaagg aacccagatc aatgactgac tcacgcgacg agcctctcgt
     5761 tctcggcatc gagacctcct gcgacgagac cggcgtcggc atcgtccgcg gcaccaccct
     5821 gctcgccgac gccgtcgcct ccagcgtcga cgagcacgcc cgcttcggcg gtgtcgtgcc
     5881 cgaggtcgcc tcccgggcgc acctggaggc gatggtcccg accatcgacc gcgcgctgaa
     5941 ggatgcggga gtcagcgccc gcgacctcga cggcatcgcc gtcaccgccg gccccggcct
     6001 cgccggtgcc ctgctggtcg gcgtctcggc ggcgaaggcg tacgcgtacg ccctcggcaa
     6061 gcccctgtac ggcgtcaacc acctcgcctc gcacatctgc gtcgaccagc tggagcacgg
     6121 cgcgctgccc gagccgacca tggccctgct ggtgtcgggc ggccactcct cgctgctgct
     6181 gtcctcggac atcacctccg acgtccgccc gatgggcgcg accatcgacg acgcggccgg
     6241 tgaggccttc gacaagatcg cccgcgtgct gaacctgggc ttcccgggcg gcccggtcat
     6301 cgaccggtac gcacgcgagg gcgacccggg cgcgatcgcc ttcccgcgcg ggctgaccgg
     6361 tccgcgtgac ccggcctacg acttctcctt ctccgggctg aagacggccg tggcgcgctg
     6421 gatcgaggcc aagcgggcgg cgggggagga ggtcccggtg cgggacgtgg cggcctcctt
     6481 ccaggaggcg gtcgtggacg tgctgacccg caaggccgtc cgggcctgca aggacgaggg
     6541 cgtcgaccac ctgatgatcg gcggcggtgt ggccgccaac tcccggctgc gcgccctggc
     6601 gcaggagcgc tgcgaggcgg ccgggatccg gctgcgggtg ccgcggccca agctgtgcac
     6661 ggacaacggc gcgatggtcg ccgcgctcgg cgccgagatg gtggcccgga accggcccgc
     6721 gtcgagctgg gacctgccgg cggactcctc gctgccggtg acggagccgc acgtgccggg
     6781 ccaccggcac gaccacgacc atgtgcacga gatcagcaag gagaacctct actcgtgacg
     6841 gtcgccatga tgtgggaggc acgggcggtg cccggccggg gcgaggacct gctggcctgg
     6901 gcccgggcgc aggagctgcc ccgcgcaccc ctgcgccggg agaccctgcg cgctccccag
     6961 gaccgggtcc tcgtcatcac ctggtgggac gccccctacg acgccgagct gccagaactg
     7021 ccggagccgg agggggagtt ggtcacacgg gccgtgcacc ggtggcggtt cgagtcggtc
     7081 ggcggcgcct gactccgggc cggccggaaa gcggacggtg gatcatccgg acactgcccg
     7141 cgcgatgtcg tccacgtcgg cgagggccgc gtcgaatccc tcgtcagcgc acacaccgac
     7201 cgggctgagc accacctcgt ccaccccggc cgcgcggtac tcctccagtt cgcgcgcgat
     7261 gcgggccggg gcgccgtatg ccaggacacc ggcctcgacc agcgcttgcg cgcccttctc
     7321 cgggtcgtcg gcgctgacgt cgaggcccgc ccggcgcagc atgtccacgt agtggtcggt
     7381 gaccagatgg cccgcgttgc ccagataggc cagccggcgc ggatcgcggc ccggccgggc
     7441 gaccgccacg tgcaccaccg cggcgatgcg cggagggcgc cggcccgctg agcgcgcccc
     7501 cgcctccagg gcgggccgga ccacctcggc caggtacgcc ggaggggtca gccaggtcac
     7561 cgccacatcg gcggtcgcgc ccgccttgcg ggccatgccg gggcgcagca cgcccgcgcc
     7621 cagctccacc cccggatgcc gcaccgggta gaggccggag gacacccggt ggtactcgcc
     7681 gtggaactcg aagtactcgc cggccagcgt gtggcgggcc accgtcaggt actcggcgac
     7741 cgcggtcgcc gggcgggcgt agggcgcgcc gagcatgtcc tgggcgaact cctgccctcc
     7801 ggtgccgaac gcggcgacca cggggtgtcc catgagctgg gccaccgtgc gggcctggag
     7861 ggccgcctcg tacgggtggc gcagcggggt gagcgccact ccggtcccca ccggcagccg
     7921 cactcccgcg ccggccaggt aggcgagcgc ctggaaggtc tcgtacgtca gcgtctggcc
     7981 catccacagc cggtggcagg ggccgtcggc cacatggcgg gcgaagcgga ccaggtcctc
     8041 gatgcgctcc ggcatgacgg ggaacatcac ggacagcgtc atcgcagcgc ctcctcccgg
     8101 tcctgctcct cctcgtcgcc ggtgccgtcc gggccgtcct cggcccggta gccggccgcc
     8161 tggaggttga acaggtaggc gtagatgccg tcgtgctcca tcagctcgcc gtgggtgccc
     8221 tcctccgcca gccggccgtc ctcgatcacg acgatcttgt ccgcgatccg caccgtcgag
     8281 aaccggtggg cgatcaccag cgacgtggcc ccggaggcga tctcgcgcag cttgccgaac
     8341 acctccgcct cggcctcggc gtcgatggac gcggtcggct cgtccagcac cagcacgggc
     8401 gcctgccgca tgaacgcgcg ggccagtgcc accttctgcc actggccgcc ggagagctgg
     8461 gccccgtcct cgaagtgccg cccgaggacg gtgtcgtagc cctcgtccag tttcgcgacg
     8521 acctccgcgg cgccgctcgc ggtggccgcg cgggcgatcc gcgcctcgtc gtccagggcc
     8581 tcgacccggc cgaagccgat gttctcgcgg gcgggcagct cgtacttgat gaagtcctgg
     8641 aagatcacgc cgatgccgga ccgcaactgg tccacgtcgt agtcctcgat gggatgcccg
     8701 tcgatgagga tccgccccga cgtcggctcg tacagccggg tcagcagttt gacgatggtg
     8761 gtcttgcccg cgccgttctg tcccaccagg gcacagcact tgcccgcggg gatcaggcac
     8821 gagaagccgt cgagcgcctt ggtgtccgtg ccggggtaga cgaacgtgac gtcccggaac
     8881 tcgatgccgt gccgcaggct ctccgggaag ggacgcgcgc cgcccttgat gacggactcc
     8941 ggcaggccga ggtagtcgaa gaggttcccc gtgaacaggg tgttctggta cagcgtggcc
     9001 aggccgacga gcatccccga actggccgcg ctcaccgagg cgatggcctg gaggaagccc
     9061 gccagctcgc ccacctcgcc ggtgtccatc gcggacagca tggccagtgc catggcgccg
     9121 gtcgcgccga ggacgccgat caggccggcc gccgcgctcc agccctcctg cttcatcgcc
     9181 agcctgcggt ccacctcgta gaagccctgg accagttcgc ggtagcggcg gatgaagtgc
     9241 gggccgagac cgaagagctt gatctccttg aaggtgtggt cctgggtggt gagccactgg
     9301 aagtagtacg cccgccgccg gtcctgggcg cggtcgtact ccacctcgaa ctcccgcttg
     9361 ccgtaggcgg cctggacgac cgccgcgggc agcggcgaca gcagggtgat cagcgcggcc
     9421 cacgggtgcc aggagaagag cgccgcgctg atggcgatca gggtgacgag gttcttcacc
     9481 gtctcgacga ggtcgctgaa gatctcgtac gcccgtccgg tggtgctctc ctggaaggcc
     9541 cgctgcagcc ggtcgtagga ctccgggtcc tcataggtcg cgaggtccat gcgggtgccc
     9601 ttggccatga cctgttcgct gatccgcgcg gtcagctgga gccccacgac cgccccgagg
     9661 tactgcacgt acgcaccgac cacatgggcc agcagggaca ggctcagaat gccggcgagc
     9721 gccgtgatca gcgcgtcgcg ggcggtgtcg ccgccggcgg ccgtgacacc gtcggtgacg
     9781 gcgtcgaccg ccgccgcggt gagccggatc tgcaggccgg ggacgaccgc cacggcccag
     9841 gtcagcaggg cgaggacgga tatccgggcg gggctgatgc gccagaacag ggccatcagc
     9901 cgcagccagt aggaggggct gcgcgacagc ttgcggttca cctcctgctc gtcgagctcc
     9961 tcggcgcttt ccccgtcgtg gtggctggcg tcaccggtgg tcatgccggt cggcctccga
    10021 tcgttctcag tacgttcttc cagaccccgt agatccgctc ctcacgggag aggtccacgg
    10081 gcaacaggcg gttcaccgtc atgtgcgcca gactcgcgag gacgtcctcc tcggtccccc
    10141 acagctcgcc ccgcgccgcc gcgtcgcgca ccgcccggcc cgccccggcc gcggcggccg
    10201 cctgcgtgac gagcaggggc gccagcgcgg cgtggtcggc gcggccccgg gggtgcggcc
    10261 gcagatccca cggggcgagc aactccccca ggtagtcgcg gtgctcccgg tacagcgaac
    10321 gcgccgccgt ctcctccgcg ccggccgcac cgggcgccac ggcgaagcgg gcccgcacgt
    10381 ccaggcccca gcggtcgtac agggcgtcga gcacggcgac ggcgacgaac tcggccctca
    10441 tgtcgagctc cccgccccac atccggtcga cgacctggag cgcggtgtca ctgcccgcct
    10501 cgaagagccg ctcgatcgcg tcgtggacgc gcgggccacc gtagcggacg acctccggtt
    10561 cgtacgaggc gatttcgagg tcgccggcga gcccgcgccg caccatgtcc cgcccgaagg
    10621 cgaggagttc ggtgagcagc gcgccgtgct ccgccggcgt cgcctgcccg ggggcgcgga
    10681 aacggatccg cagatggggg cggggatcgg cgtaccggat gaagaaccac cggtcggcgc
    10741 gtccgtcgcg gcgcagggcg tcggcgaggg cgcgcagcgg gccggccagg atctcgtcgt
    10801 gccggtcgaa gcaggagtag agcttcaggc acgaccaccg gtccccgggc aggtgccggg
    10861 gacgcgcgac ggcggccggg gcgtggcgcg gcgaggtccg gtcgggagcg gccggttgtg
    10921 cggcctggcc ggccggcagc agcgggacga ccagttcgct cacgtacgcg tcgccgctct
    10981 cgtcacgcag ccacagcccg tcgaagccgg gcagcatctc ctggagccgg acggcggagg
    11041 acgtgcgcag ctcacgcagg agttccgtcc ggcacccggg ccggtcgagg tcgagcagca
    11101 gccggttgtc gtgctcgacg aggtacacgt accggggaac ccgccactgg gcgcgccagc
    11161 gggccagcgc gtcccgcgtc tcgggggtgt ccgtggcgcc gggcgcgggt tccgctgccc
    11221 gcgcaccgct gtcggtgggc cgggcggcgg ccagttgccc ggcggtgagg gtccactcgg
    11281 ccgcgcgcag gacgacacgg ccgcgcacga cgcgcggcag atacggtccg ccctccagcc
    11341 ccgcccaggt gaagccgccg accgtgcgcc gccgcagccg cgagacgtcg gtgaggaaac
    11401 ggcagacgtt gggcgcggcg gccggggtga gcatgtgccc ctcggccacg atcacctcac
    11461 gtcccagccg gcgcgaccac aggaacagcc ccgtgtggtc ggcggcgacg tacaggtcgt
    11521 cgagggcgat cacccgttcc tcggggaccg tcggcggcac gttcaccggt atctcgaagt
    11581 cgtggtgcag cggccgtacg gccacgttcg caccgcggcc gtgcgcgggc acgtagctca
    11641 gttcggcgac caccgcgtgc ggtgcgagct cctgccggtg ccgcgcgtac cggcgcaggc
    11701 cctcccgctg tgcgtcgtcg aacaggtcga agaaccggcc gaaggtgcag ccgcccggtg
    11761 cgagcccgtc gtcgttgagc accagccgcc actcaccccg gtcgatcgcg tcggcgccgg
    11821 cggcgtgcac ctggagatag acgtccacgg cggccacggg ggtgccggcc ccggccccct
    11881 ggtgccgtcc gtgcccgtga gcggcccggt cctcggcccg gtcgcgcagc gcggcccgga
    11941 ccagccggtc ctccagggcg tcggacagtt ccacggcgcc gcccggcggt gtgcccccga
    12001 gctgctcggc cagtacgcgt tcgtaggcac gggtgaccgg ttcgggcccc ggctcggggg
    12061 gtgcggcggg cggcggctgg aggtagccgg caggggcgtc gaggccggtg agagggctga
    12121 gcacatcggt gagcgggacg agggctcccg tgccgtagcg ctccatgaac gcctccgcgt
    12181 aggccgccag gtgacggtcc gggccgggca gggcgtcggc gagccgggcc aggacgccca
    12241 cggcgtcggc ggcggcctca cccacggcgg cggtcatccc gccgccgcgc aggtcggccg
    12301 ccgcgtccag gtggaacgtc tcgccccggt gggcggggac gagggcgcgc tgcgccgcgc
    12361 gcagggcgac cagttcgtcg gcggtgtccg aggtctcggc gtggcgggcg gcgcctgcca
    12421 cgccgtccag ctcccgggcc agatcggcgg ccgtggtccc ggcggtcttc gccagtcgct
    12481 cggccacgtg gtgctcggga tgcggcaggg tgagcggcgg acgcaggtcg gagagcagga
    12541 acccgaggtc gagcagttcc ccgatcagcg cgttcagccg ctcggccggg gcgtccggga
    12601 acgcggcgga gagttcggcg acgacttcgc cgtacgggca ggggacgggc ccgcgcgtgc
    12661 gctcgcgcac caggcgtacc gcctccgtgt cgaggatccg ggccgccttg ccctcgccct
    12721 gcccgtaggc gtccgcctgg gggagcacga tccgttcgcc cgacgggtgc gccagggcgt
    12781 tccacaccag ggcgagaccg tcggccgcgc cgacgcgctg ctgtgcctcc cggacgaaca
    12841 gcatcagcca gcccatgtcc gcccgtatcc gctgccgtcc gacggccccg gcaccgagcc
    12901 gggcggtggt acgcggcccg aactcgccca tcgtcacagc cgcgaaggcg ccgtaggggg
    12961 tcggccgggt gctcatccgg gtcagatagc gcaggaggcc ggagcggatg cggcgccccc
    13021 gcttgccgtc gccgggctcg tgcccctccc gcagcgcggc acccaggctg gggctcgcga
    13081 cctccagtgc ccggcgcacg cgcggggtgc cggacagcgc gctcagggcg gcgtcgtcgg
    13141 tgagccggtg gaaggtggac gcgggcaggg ccggggtgcg caggaggaag aacccggcgt
    13201 gccggtaggg ggacgggggt gcggccatgg cttcaaccac ctcggctggg aagggaacgt
    13261 gctgcgggaa ggggcggtgg cccggctggc ggatcctccg gcgggcgctc aggacaggaa
    13321 gaacgcggtg aaccagcggg gccggtcgcg acccgtgacc gcgaacaggg tgagcgcgac
    13381 gccggcggcg ccggtgagca gcccggggtc gtccacgaag ttgccgggta cgtcctggtc
    13441 ggcgaagagc agcggccggt cgtcctcggc gtacgcgagg agctcgccga ccagcgaggg
    13501 gagcgcggcc tcggcgttcg gggagcgccc ggaggcggcg aactcggcgc agacggccac
    13561 cagtcccgcc atgccgtggc acagcgtggg ggacaggacg gtgccgcggc ccgggccgcg
    13621 ccgcagcacg gcgtcgaacg cgtccgcggc ggcggaaccg gccgcgtcgt cgccgagcgc
    13681 ctcggcggcc cgcagcagtg cgacggcgac accggcggtg ccgtagcacc aggccagctg
    13741 gtcgtgtgcg tggggcagcg cgtcgttcgg aacggtacgg ccgttcgcgt cgagcggcac
    13801 cccgcgcgcc cacagcggcc cctgcgcgtc ggtcagccgt acggccagca gccagtccac
    13861 gaggccgcgc agtgccgtgc gggtctccgg ggcgcggtgc ccggcgcgca gagcggcggc
    13921 gagcgcgccg gccacgccgg ggacgccgtg ggagaggccg aggttcagat agccgtgcgg
    13981 gtagtcggcg cggtactcgt cgagcgggta ccagcggggc gcgacggcca gggcgtacgg
    14041 cggaccgtcc ccggtgctca gccgcagcag gaagtccagt gtccgatccg tggcctcgcg
    14101 catccgcggg ctcggcgagt cgaccgtgca ctggtgggcc agcacgccgg ccgcgccgtt
    14161 gatggcgtcg tagtcgtggt cggccacggc gcccgagggc cggtccacgg ccaggacctg
    14221 gtcggccaga cgctcgtgca gccggtccat gctcggccgg aagcggggct cgtcggccgc
    14281 gaagtcggcg agggcgagcg cgagtccgct ggtgccgccg aacatcccgg gttcgggcac
    14341 gggctcggtc tcggtgtgct cgaacgccgc cctgaggaag gcgaaggccc ggtcgtacgc
    14401 ggccctgcca ccgccggcgc gggccgcgta caggtggagc agggccagtc ccgcgtgccc
    14461 gtggctgagg gaactgccgt cccacacggc gtcgtcggac tgggccgccg cccgtgcggc
    14521 cagttcgggc agcaggtggg gtccggcgag cgcgtcggcg acccggtcgg cggcctgccg
    14581 ggcccgggcg gtgagcgggg cgggcagcgc gacgcggccc cagtggggtc cggaggtccg
    14641 gtcggagggg ctggtacggg tgtgcgtggg catggtccct ggctcgctgg gcaggcggac
    14701 aatacggacg gtggtgagat cccgggaggc cggaagaggg cgggcccgga ggcggtaggc
    14761 gccggtaggg tgcgacgggg tgggggctgt cgtgaattgg cctcacgaca gcccccgcct
    14821 tcaccgcggc atcgctcgac cggtcggcgt gtgccggccg gccacgtcat ggcgcgccgt
    14881 gtgaaggctc agtgcacgcg gattcagcac ttgaaggtgc agcccttgca ggtgcaggtc
    14941 ttgatcttcg tgcacttctt ggccgagacc ttggtcacga tgctgaccgt gatggtgggc
    15001 gtcccctgga cgacggcgtc cccaccggaa ccgctgacgc gggcgtccag ggcgaacgga
    15061 tccttcgcaa cagccatgtt ggcttcctct ctgtgacatc gaacacaccg ccaggggtct
    15121 gacggagagc cgtcactgtg gcgcacaccc gttcttgaac cgttccagga gcgtccttgt
    15181 ctcgttcttt acctttgtgc cggtcgggac ttcgcagaag acacatgtct gtcaggaagt
    15241 caaaaagcgc tacggtgctg actcgcggcc gaaaccggcg tgatctcacc cggtcgacgg
    15301 ccgtggccgt ccgaccgaca ctcgccgtga cgggggagct gaccactccc cggtgatcca
    15361 cggcgcaaca gggggagatt cacgtgcaga cgtgcgagga cttggagatc agactgctgt
    15421 cggggtcgcc ggccctggcg agtcgtggcg gagtcagcat cctgcccgcg tcgtcccacg
    15481 cggcccggct ggtggccttt ctgggggtcc atcgcgggga gcgcgtcagc cgggacaggc
    15541 tcgtcgacct tctcggcctg tcgcgggcgg cagacccccg cgccgcgctc cgcaaggcgg
    15601 tctggcaggt gaacaacagc acggacggaa ggttcctgcg cggcacgcgc acggacctcg
    15661 gtctcgccga cggcgtccgt gtcgactacc aggaggcccg ggaacgctgt ctgggcctgc
    15721 tgcgtcgcgg gttcaccgag gtcgccacgg ccgatctgcc ggctcgtttc cgcgcccagc
    15781 tcgagagcga ggtgctcggg gagttcgagg aggactgggt ggtcgcctgc cggcaggagt
    15841 ggcagcggct gcggctggaa gtgctgcacg ggctggccga ggcggagctg atccggggca
    15901 acgcgcgtgc cgccgtgatc agtgccgaac aggtcgtgcg gtgcgacccg ttgcgggagg
    15961 gggcctggca caccctgctg agcgcgctgc tggccagccg tcaccgggcc gcggcacgac
    16021 agcggttcaa cgaactcgtc gacctgctcc gggacgacct cggcgtggca ccgatgttct
    16081 cctgggagga gctgctggag gacccgccgc gagcgcccgt caccggcctt tgggtctgac
    16141 cggcctcacg tgcctcacgg cagctccgag acctccgtct cgcagcgcag ccgccggtcg
    16201 gcgccgagca cccggaccgg gcccgtgagg gtgaggcgcg cggtgtggcg tacgtccgcg
    16261 ctggacgccg ccagccgcag ctccagggcg ccgggttcga ccacgcgcct gcccgagcgg
    16321 tcggtgaacg ccgacaggtc cgcgtggaag cggaacgtca cccgcaccgc ctcgcccggg
    16381 gccgccgcca cgcgctggta gccgatcagc cgtacgtcgg gccgggtcac cgacgccacc
    16441 ggatcgtgca gatacagctg cacgacctcc gccccttcgc ggtcgccggt gttgcggacg
    16501 gtcaccgaga cgtcgtacgt cccgtcggtg ccgatctccg ccggctcctc gccgcccgtg
    16561 ccgtcctccc agacgaacgt cgtgtacgag cgaccgtgcc cgaaggcgta cagcggggtc
    16621 gggtcgaggt tgctgacctc gcccgcgagg ccgaggggcg gctggaggta cgtccagggc
    16681 tggccgccgg ggacctgcgg gacgctcacg gggaggcgac ccgacgggtt cacgcggccc
    16741 gacagcactc ccgccaccgc cgggccgccc tcctcccccg ggaagaacgc ctggacgacc
    16801 gcgcccaggc ggccgtgcca gcggccgaga gcgtagggac ggccggtcag cagcaccagc
    16861 accacgggga cgcccgtggc gaccagcgcg tccagcagct cgccctgggc gcccggcagg
    16921 gcgaggtccg tcgcgtcgca gccctcgccc gaggtgccgc ggccgaacag ccccgcccgg
    16981 tcgccgagga ccgccacgca cacgtccgcc tcggcggtgc gggcgacggc ctcctcgaag
    17041 ccggaggtgt ccgggtccgt cacgtcgcag cccggcgcga acgtcacctt ggcgtcgggg
    17101 agttcggtgc gcagggcgtc gaggaccgtc gggatctcga tgccggtcgg gacgcccggg
    17161 tggtgggtga ggacgtggga cgggaaggag tagcagccca gcatggccag ggcgtcggcc
    17221 gcgcgggggc cgatcaccgc gatccgggtg tcgggggcga gcgggagcag gccgtcgggg
    17281 ttgtcgagca ggacgaccga ctcctcggcc aggcggcggg ccaggatgcg gttgcgcgtc
    17341 gagtcgagct cgaccggggc ggccggctcg ggggcccagt cctcgtccag caggcccagt
    17401 tcgcacttct ggagcaggac gcggcgggcc gcgcggtcca ccagctcctc ggggatctcg
    17461 cccgagcgga ccgcgtccac cagcggatcg ccgtagcact tgaggctcgg cagttcgacg
    17521 tcgatgccgg cctccagggc cgcgtgggcc gcctcggccg gggtgccggc cacccggtgg
    17581 agggtctgga ggaagccgat gccgaagtag tccgcgacga ccgtgccggt gaagccccac
    17641 tcctcgcgca ggagtccggt cagcagctcg gggtccgccg aggccggcac gccgtcccgc
    17701 tccgtgtacg cggccatcac cgaacgggcc ccgccctcgc gcagcgccat ctcgaagggc
    17761 gggagtgtga cgtccgcgaa ctcgcggatg ccggcccgta cgggtgccag gttgcgggcg
    17821 cccgccgagg aggcgtaccc ggcgaaatgc ttcagcgtgg cgacgacccc ggccgactcc
    17881 aggccccgca cataggccgc gccgaccgtg ccgaccaggt acgggtcctc gccgatcgtc
    17941 tcctccacgc ggccccagcg cggatcgcgt acgacgtcca ggacgggcgc gaggccctgg
    18001 tgcacgccgg ccgagcgcag gtcgtcgccg atgcggcggg ccatctcctc gaccagcggg
    18061 ggatcccagg tcgctcccca ggccagcggg accgggtagg ccgtggcctg ccaggcggtg
    18121 aagccggcca ggcactcctc gtgcgcgatc gccgggatgc cgaagcggcc ggcctcgatg
    18181 atgcggcgct gggcgcgggc cagtgcctgc gcgcccagcg ccgggtccac gggggcggtg
    18241 ccgaaggagc gcgtgagctg gcccaggccg cgggtgatca gctcgtccca ctcgtagtcc
    18301 acagtcatgt cgtgctggtg cggagcgact ccgtcgccgt ccgtcgaagc gcccacccac
    18361 acgccgtaca gctgggcggt cttctcctcc agggtcatcc gggagagcag gtcgtcgacg
    18421 cgggcggcgg cgggcagggc ggggtcacgc cagggcgcgg tggtcatgaa gctcctgtcg
    18481 ggtggacgga cggccctctc acgaacggtg ctcacgagcg tctctcacgc ccgcttccac
    18541 gaatgtttcg gtaagtatgt cgaatgttcc gggaacctat ggcgccccgg ggacttcgtc
    18601 aagggggccc gcagggatac gatcgccgcc atgacatccc cggagccggt ggaaagccgg
    18661 acgcaaaacc ggacgcaggg gcgcagcgcg cagaccgcga cgctcgccga gatcgcccgt
    18721 gaggccggtg tgtcggcgcc gactgtttcg aaggtcctca acggccgcgc cgacgtcgcc
    18781 cccgcgaccc gggcccgtgt cgaggatctg ctgcgggccc acggctaccg gcgccgccgg
    18841 gccgaggcga cccgctcacc cctgatcgac ctggtcttcc acgagctgga gagcgcctgg
    18901 gcgctggagg tcatccgggg tgtggagaac gtggcccggg acgcggggct cagcgtggtg
    18961 ctgtcggaga gcgcggggcg gctcaccccc gggcggacct gggccgacca ggtcgccgcg
    19021 cgccgcccgc acggcgtggt cctggtcctg tccgggctcg acgagtcgca gcgggcgctg
    19081 ctgaccagcc gcgccatccc gttcgtggtg atggacccgg ccggcgaccc gggcgccgac
    19141 gtgccgtcca tcggcgcgac caactggcag ggcggtctcg cggccacccg gcatctggtc
    19201 gagctggggc accgcaggat cggcgcgatc agcgggccga cgcagatgat gtgcagccgc
    19261 gcccgggtcg acggctaccg ggccgcgctg gagacggccg ggctgccggt cgaccccggg
    19321 ctgatcgcga acggcgactt ccaccacgag gccggctacc ggctgggtct ggagctgctg
    19381 cgccgcccgg accggccgac cgccgtcttc gccgggaacg acctccaggc gctcgggctg
    19441 tacgaggccg cgcgcgagct ggggctgcgc atccccgagg acctgagcgt ggtcgggttc
    19501 gacgatctgc cggtggcgcc cctggtcggg ccgccgctga cgaccgtacg gcagccgctg
    19561 acggagatgg ccgaggccgc ggccaagctg gtcctcgacc tcggccgtga ggcgggcacc
    19621 ccggctgcca cccgggtgga gctggcgacg agcctggtgg tgcgcagcag tacggcggcg
    19681 ccagcgggcg gctgaccgct gaccgctgtt gccgtattga cgggtgttcc gagcgtctcc
    19741 acactgcacc gaagccaatc ggttgcacca ccgaaacttt cggaggcacc cgcaatgaga
    19801 tcgctgagat cgggcttact cgcatccctg ctggccggag tcgtcacggc cggctccctg
    19861 ctgctcgcgg cccccgtgtc gcacgccgcc gacgtcccgc tgcgcgacct cgccgaagcc
    19921 aaggacaagg tcatgggcac ggcggtcacc ggctcgaaac tcaccggcac ctacggcgag
    19981 atcgccgggc gcgagttcaa ctggctcacc cccggcaacg ccatgaagtg ggggtccgtc
    20041 gagccgagcc ggggcagcta cgactgggcc gaggccgacc agatcgtgga cttcgccgag
    20101 gcccacgacc agcaggtgcg cggccacacc ctgctctggc accagcagaa cccgggctgg
    20161 ctgacgaacg gaagctggac ccgggaccag ctcagcgcca tcgtccagga ccacatcgcc
    20221 accgaggtcg gccgctacaa gggccggctg gccgcctggg acgtggtgaa cgagcccttc
    20281 aacgaggacg gcacctaccg ccggaccctc ttccacgaca ccctcggcca ggactacatc
    20341 gcgcaggccc tcacctgggc ccgggccgcc gaccccggcg ccaggctgta catcaacgac
    20401 tacaacgtcg agggcgtcaa cgcgaagagc acggccctct acaacctggt caagtcgctg
    20461 aaggagcgcg gcgtcccgat cgacggagtc gggctccagg cccatctcat cgtcggccag
    20521 gtgccctcga cgatgcagca gaacatccag cgcttcgccg acctgggcgt cgacgtggcg
    20581 atcaccgagc tggacatccg gatgcagctt ccggcgacgc aggcgaagct gacccagcag
    20641 gccgccgact acaaggcggt catgaacgcc tgcgtggcgg tcgcgcgctg ttccggcgtc
    20701 accgtctggg gcttcaccga ctccgactcc tggatcccgg acaccttccc cggccagggc
    20761 gcggccacgc cgtacgacga gaactaccag ccgaaaccgg cgtaccacgc catcgccgag
    20821 gcgctcggcg ggacgacgac cccgcccacg ggcgcctgct cggcgacgta cagcgtcacc
    20881 agccagtgga gcacgggcta tacgggccag gtgcggatcg cctgctcggg ggcctcgctg
    20941 tcgtcgtgga aggcgaactg gacgttcggc gccgggcagc ggatcgcgca ggcctggaac
    21001 gcgagctgca cgcagtcggg tgcggcggtg agttgcgtga acgcctccta caacgggtct
    21061 gtgccggacg gtggttcggt cacgttcggc ttcaacggct catggagcgg gagcaacccg
    21121 gtgcccgtgg tgactctggg gtgagaccgg acggagaagt ctgagaattt ccgaagaaaa
    21181 tcgccctggg ggtcctgctc gtaataattc ggacttacgt tcctgcccgt gacaggacgc
    21241 gacgggagcg gggacgcggg cagagcagtg ggccggcggt ccagagcgct gcggatcgcc
    21301 ggcttctccc tcgcgggtgc gctggtgctg ggcatcgggg cggcgggctg ggcctaccgg
    21361 catctcagcg acaacatcac cagcgtcgac atcgacaacg cgctgggcga caaccgcccg
    21421 ccgaagccgg aggtcacgcc ctcctcctcc gcagcggccc tgcccagcga ggcgctcaac
    21481 atcctggtcc tgggctcgga ctcgcgcagc ggcgaggaga accgcaggct cggcggcggc
    21541 gacagctccg gtgcgcgctc cgacacggcg atggtcgtcc acctcgacgc cgggcgcacc
    21601 ggcgcgacgg tggtgagcat cccgcgcgac accctggtca cccgcccctc ctgcccgcgc
    21661 ccgtccggcg ggtcgacggc cgtcgcgcac cactccatgt tcaacaacgc ctacgcggtg
    21721 ggcggtccgg tctgtgcggt caaaacggtc gaggcggtca ccggcgtccg catggaccac
    21781 tacatcgaga tcgacttctc cggcttcgcg aagctcgtcg acgcgctcgg cggcgtcacc
    21841 gtcaccacgg acgaggacat cgccgacgac gacagccatc tgcgtctcaa ggcgggcacc
    21901 caccacctgg acggcacccg ggccctcgcc ctggcccgca cccggcacgg cataggagac
    21961 ggcagcgacc tgggccgcat aggcctccag cagaagctgg tgaaggcgct gctggaacag
    22021 atcgccgcgc gggacctgct caccgacccg gcgaagctgt accgggtcgc ggacgccgtg
    22081 accgccggcc tcaccaccga caccggcctg gactccctcg ccgagctgac ccggctcggg
    22141 cagagcctga aggacctgtc ggcgagcgcg gtacggacgg tgacgatgcc ggtggtgcgg
    22201 gcgccgtcgg atcccaaccg ggtggtggcc gaggagcccg aggcgcggga gctgtgggag
    22261 tcactgcgct gacctgtaca aacgcgctcg gaaaaattct tggagaaaag tccggcgagc
    22321 gtgtcgatcc ggacgtctcc cgatcgacgc aggggtgaga gcggggaaag gcctcgctcc
    22381 gcagagcccc gaggagtcac catgccgcgc tttctcaccc tgatccgcat cgacgagaag
    22441 aacgcccccg ccgagggccc gagccccgaa ctccaggagc ggatgggcaa gctcctggag
    22501 gagatcacca aggccggggt catgctcgac acggccgggc tcaccccgac cgcggacggc
    22561 agccgggtga cctgggagga cgggaagctg tccgtcaccg acgggccgtt cacggagtcc
    22621 aaggaggtca tcggcggcta ctcgatcagc cagtgcaagg acaaggccga ggcgatcgag
    22681 tggaccaagc ggttcctgtc cctgcacgag gactactgga cgatcaccgc ggaggtccgg
    22741 cagatcgccg agggctgacc ggtcctcctt ggccggaagg cgccacgggt gtctgatggt
    22801 gggctgtgac cccgcagccc accgccgacc cgagcggcac cacggccgat ccgagccgca
    22861 ccaccgccgg tccgagcggc gctacggccg gcccgagcgg caccgcggct gatccgagcc
    22921 gcacaacggc cggtccgagc ggcgctacgg ccgacccgag ccgcaccact accgacccga
    22981 gccgcaccca cacagccatc gaaacagtct tccgcatcga gtcgccccgc atcatcgccg
    23041 gcgtcgcccg ggtcgtccgg gacgtcggca tcgcggagga actcgcgcag gacgcgctgg
    23101 tcgccgcgct ggagcagtgg ccccgggacg gggtgcccga caacccgggc gcctggctca
    23161 tggccaccgc ccgcaaccgc gccgtcgacc tggtccgccg ccgcgagaac tacgcccgca
    23221 agctggcgga gatcggccgg gacctgtcga cggtgtctcc cccggaagag cccgccgacc
    23281 cggacgacat cgacgacgac ctgctccgcc tggtcttcac cgcctgccac ccggtcctgt
    23341 ccaccgaggc ccgcaccgcc ctcacgctgc gcctcctcgg cggcctcacc acggccgaga
    23401 tcgcccgcgc gttcctggtc cccgagccga ccgtcgccca gcgcatcgtc cgcgccaagc
    23461 gcaccctggc gacgcggaac atcgccttcg aggtgcccta cggccccgac cgcgaggccc
    23521 gcctcggctc ggtcctcgac gtcatctacc tcgtcttcaa cgagggatac gccgccacgg
    23581 ccggcgacga ctggctccgc ccgtccctgt gcgaggacgc cctgcgcctg gcccgggtgc
    23641 tctcggccct catgccgaag gaacccgagg tgcacggcct gaccgcgctc ctggagttcc
    23701 aggcgtcccg cacggcagcc cgcacgggcc cctccggcga acccgtcctc ctcaaggacc
    23761 agaaccgcgc ccgctggaac cgcatgctca tcggccgcgg catcaccgcg ctgggcaggg
    23821 ccgaggccgc ctcctccggc accccgggcc cgtacctcct ccaggccgcc atcgccgcct
    23881 gccacgcgca cgcgtacacc tacgaggaga ccgactggtc ccgcatcgcc actctgtacg
    23941 gcgtcctggc cgcccgctcc ccgtcgccgg tagtcgaact gaaccgcgcg gtggccgtct
    24001 cgatggccga gggcccggcc cccgccctgg ccatcgtcga ctccctgctg gccgaccccg
    24061 ccctgcggga ctaccacctg ctgcccagcg tgcgaggtga cctcctgtcc cgcctgggcc
    24121 gcacggcgga ggcccgggcg gagttcgaac gggcggcgtc gctgacgcgc aacgagcggg
    24181 aaagggaact gctgtcgcgg cgggcggcgg agcagacctg acggctcctg cccacgcggg
    24241 gtgccggctc ccgcctacgc ggggtgcccg atgagcatcg ccggtgctcc cgccacccgc
    24301 gtcaggaaca ccgtggccga gtgccggccc tgaggcttca ccttcctgcg gagctcctcc
    24361 ggctcgaccg ccgagccccg cttcttcacc gtgaggttgc cgacctcccg ctcccgcagc
    24421 agggccttca gcttcttgac gttgaaaggg agatggtcgg tgatctcgta ggcggtggcg
    24481 tacggggtcg ggtgcagtgc gtcggccgtg acgtacgcga tggtcgcgtc gagcagtccg
    24541 ccgccgacct cgtcggccac ctcggcgacc agatgggccc ggatgacggc cccgtcgggc
    24601 tcgtagaggt agcggccggg cgggcggacc gccgggtcgg gcaggccgcg ggagagcagc
    24661 gtgcgcgggc ccg
//
