LOCUS       NZ_CP023694            22700 bp    DNA     linear   CON 13-JUL-2024
DEFINITION  Streptomyces coeruleorubidus strain ATCC 13740 chromosome, complete
            genome.
ACCESSION   NZ_CP023694
VERSION     NZ_CP023694.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces coeruleorubidus
  ORGANISM  Streptomyces coeruleorubidus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 9335698)
  AUTHORS   Lee,N. and Cho,B.-K.
  TITLE     Direct Submission
  JOURNAL   Submitted (27-SEP-2017) Biological Science, KAIST, 291 Daehak-ro,
            Daejeon 34141, South Korea
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 2.3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 50X
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_008705135.1-RS_2024_04_23
            Annotation Date                   :: 04/23/2024 03:16:00
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,499
            CDSs (total)                      :: 8,405
            Genes (coding)                    :: 8,179
            CDSs (with protein)               :: 8,179
            Genes (RNA)                       :: 94
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 73
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 229
            CDSs (without protein)            :: 226
            Pseudo Genes (ambiguous residues) :: 0 of 229
            Pseudo Genes (frameshifted)       :: 96 of 229
            Pseudo Genes (incomplete)         :: 175 of 229
            Pseudo Genes (internal stop)      :: 12 of 229
            Pseudo Genes (multiple problems)  :: 53 of 229
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 14:54:21
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3183592
            Orig. end                         :: 3206292
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP023694.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria available from Korean Collection for Type Cultures.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22700
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="10"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..22700
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22700
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12700](+)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12700
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     gene            complement(461..1675)
                     /db_xref="GeneID:91417324"
                     /locus_tag="CP976_RS14685"
                     /old_locus_tag="CP976_14725"
     CDS             complement(461..1675)
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91417324"
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010042107.1"
                     /locus_tag="CP976_RS14685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_14725"
                     /product="sensor histidine kinase"
                     /protein_id="WP_150480769.1"
                     /transl_table=11
                     /translation="MRSVQVPTTGNRIMAVINRDPLTAPHAVRNDALLAVVAAVLAVGL
                     ALFVDDGRRPDALGWTLLLACHVPLAWRRRRPLLVLLAIVACVAPYHALDNTHTAPTPA
                     TYIALYTVAVTGRPLRTVLVGVGVITLSTSVMLTVSMHEALKVLQISGWVVAVLFCGAD
                     VRFYRQYVASIVERAERAERTREEEARRRVAEERLRIARDLHDLLAHSITLIGVQTSVA
                     AHVLSADPERLDRETVAKALDDIAETCRSARGELRTTLEVLREHDSPDARGPLPGLDGL
                     TDLAEAARLAGARVEQTVRIRQAPPAVGAAAYRIVQEALTNAVRHAGPEPAVRVDLDER
                     QGALHLTVSDDGTGPAPGGTPGFGLVGMRERARSVGGTLDAGPRTGGGFEVTAVLPLTT
                     GERAG"
     gene            complement(1725..3815)
                     /db_xref="GeneID:91417325"
                     /locus_tag="CP976_RS14690"
                     /old_locus_tag="CP976_14730"
     CDS             complement(1725..3815)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91417325"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1035: MMPL domain-containing transport protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003990124.1"
                     /locus_tag="CP976_RS14690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_14730"
                     /product="MMPL family transporter"
                     /protein_id="WP_167537339.1"
                     /transl_table=11
                     /translation="MGDTRNTARRRAVPWAVVGLWLAALVLVGPLAGKFAGIQQNRAVD
                     YLPDSADSTQVARIQDRLPGGESTDLVLVYHRDGGLTDADRRTAAEQIAEVRGAYDVTG
                     EPRGVPSEDGSTLMYPVSSTQPGQDEEARNAFVDGVREVAEGSGGLSVEVGGPGALNTD
                     MGKVFETIDGTLLLATLAVVTVLLILIYRSPFLWLVPLAVAGVAATTAMAAGYGLHELF
                     DVTVTGQSGGVMTVLVLGAGTDYALLLIARYREELRRHERPYDAMRTALRGCGPAILAS
                     SGTVAAGLLCLLAADLNSSSGMGPVGTVGVLAALVAMTTLLPAVLVLLGRRVFWPLIPA
                     FGSEPKARRSLFAAMGTSATRRPVTVLVGGGVLLGALALGTLNLSGSIKQEDSFTERPE
                     SITAMQTLAREYPERSSRPVTVIAPDERTDVVLDRARETEGVAEAVPGRSGSGWTEIAV
                     FTAASPETPAETRTIEALRTGLDTAGAYVGGPSAQQIDLADSESRDRKVIVPLVLGAVF
                     VILVGLLRSLVAPLLLLAAVVAVWGAALGIGGLVFEPVFGFGGTDPGLGLLSFVFLVAL
                     GVDYGIFLMHRMREESVKGAEPEAAALTALRTTGGVIASAGVVLAATFAVLTTLPLVGL
                     VELGFVITVGVLLDTFLVRTYLVTTASVLLKRRMWWPGRLSRAPEQPAGAEQGRVRSPA
                     SR"
     gene            complement(3988..4686)
                     /db_xref="GeneID:91417326"
                     /locus_tag="CP976_RS14695"
                     /old_locus_tag="CP976_14735"
     CDS             complement(3988..4686)
                     /codon_start=1
                     /db_xref="GeneID:91417326"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003990125.1"
                     /locus_tag="CP976_RS14695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_14735"
                     /product="TerB family tellurite resistance protein"
                     /protein_id="WP_150480770.1"
                     /transl_table=11
                     /translation="MLPGRGRNGHAARLSGILGTRTAWTPAGDGEFFCPGCGGDRNYQR
                     LTGQRRFTLLGLPVLPRGETGPVVECAACRRHFGMDVLDHPTTTRFSAMLRDAVHTVAL
                     AVLAAGGAGSRTALESAVLAVRAAGFDDCTEEQLAALVEALEADTGRITGEPCGAGLAI
                     ELHEALDPLAPHLATVGRESILLQGARIALADGPYTPAERDVLATVGAALTICSDDVTR
                     VMAAAARTPS"
     misc_feature    complement(4773..4788)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: strong,
                     score: 18.33"
                     /tool="antismash"
     gene            complement(4873..6594)
                     /db_xref="GeneID:91417327"
                     /gene="leuA"
                     /locus_tag="CP976_RS14700"
                     /old_locus_tag="CP976_14740"
     CDS             complement(4873..6594)
                     /EC_number="2.3.3.13"
                     /GO_function="GO:0003852 - 2-isopropylmalate synthase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009098 - leucine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91417327"
                     /gene="leuA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HMGL-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1271: 2-isopropylmalate synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015660485.1"
                     /locus_tag="CP976_RS14700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_14740"
                     /product="2-isopropylmalate synthase"
                     /protein_id="WP_150480771.1"
                     /sec_met_domain="HMGL-like (E-value: 2e-73, bitscore:
                     246.2, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MANRQQPSSMPIHKYGRYEQVDIPDRTWPDKRITTAPRWLSTDLR
                     DGNQALIDPMSPARKRAMFDLLVKMGYKEIEVGFPASGQTDFDFVRSIIEEPGAIPDDV
                     TISVLTQAREDLIERTVESLKGARRATVHLYNATAPVFRRVVFRGSKDDIKQIAVDGTR
                     LVMEYAEKLLGPETEFGYQYSPEIFTDTELDFALEVCEAVMDVWQPGPGREIILNLPAT
                     VERSTPSTHADRFEWMGRNLSRREHVCLSIHPHNDRGTAVAAAELALMAGADRVEGCLF
                     GQGERTGNVDLVTLGMNLFSQGVDPQIDFSDIDEIRRTWEYCNQMEVHPRHPYVGDLVY
                     TSFSGSHQDAIKKGFDAMEADAAAKGVTVDDIEWAVPYLPIDPKDVGRSYEAVIRVNSQ
                     SGKGGIAYVLKNDHKLELPRRMQIEFSKLIQAKTDAEGGEVTPKDIWAAFRDEYLPNPE
                     NPWGRIQVKNNQSTTDTDGVDTLTVEATVDGQDTVLTGSGNGPISAFFDALQSVGIDVR
                     LLDYQEHTMSEGASAQAASYIECAIGDKVLWGIGIDANTTRASLKAVVSAVNRATR"
     misc_feature    complement(6871..6889)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 17.54"
                     /tool="antismash"
     misc_feature    complement(6880..6895)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.94"
                     /tool="antismash"
     gene            6916..7986
                     /db_xref="GeneID:91417328"
                     /locus_tag="CP976_RS14710"
                     /old_locus_tag="CP976_14750"
     CDS             6916..7986
                     /codon_start=1
                     /db_xref="GeneID:91417328"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003990128.1"
                     /locus_tag="CP976_RS14710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_14750"
                     /product="M4 family metallopeptidase"
                     /protein_id="WP_150480772.1"
                     /transl_table=11
                     /translation="MTTHGGFEPVFCTIVPPHVLDKLSQAEDPALAGPARRTLERDALE
                     RTHRRLTTVVGAPSVAPPAGAEPARPHRTVHDARHGTDLPGHKVRGEGDKPGKDATVNR
                     AYAGLGATFELLLKAYRRDSIDGNGLPLDATVHYDREYNNAFWNGEQMVFGDGDGEIFL
                     DFTIPIDVIGHELVHGVTQYTANLTYFGQPGALNESVSDVFGSLIKQYTLGQTAAEADW
                     LIGAGLLAPRVTGKALRSMKEPGTAYDDDVLGKDPQPATMDDFVRTGRDNGGVHINSGI
                     PNHAFYLAATALGGHAWERAGLIWYDVLTGGELKQQAMFADFATLTVKAARERFGDGEE
                     LEAVSKAWEQVGVRTL"
     gene            8007..8273
                     /db_xref="GeneID:91417329"
                     /locus_tag="CP976_RS14715"
                     /old_locus_tag="CP976_14755"
     CDS             8007..8273
                     /codon_start=1
                     /db_xref="GeneID:91417329"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020116275.1"
                     /locus_tag="CP976_RS14715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_14755"
                     /product="protealysin inhibitor emfourin"
                     /protein_id="WP_059414081.1"
                     /transl_table=11
                     /translation="MRIQVRRTGGFAGIERHAEVDTSGRPDAPEWHALAEQAVAAGRST
                     PPIGVPDGFSYQITVDGKTVYAADPRLTDEQRKLISRVLKEGA"
     gene            8332..9669
                     /db_xref="GeneID:91417330"
                     /locus_tag="CP976_RS14720"
                     /old_locus_tag="CP976_14760"
     CDS             8332..9669
                     /EC_number="3.2.1.21"
                     /GO_function="GO:0008422 - beta-glucosidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0030245 - cellulose catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91417330"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010042098.1"
                     /locus_tag="CP976_RS14720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_14760"
                     /product="GH1 family beta-glucosidase"
                     /protein_id="WP_150480773.1"
                     /transl_table=11
                     /translation="MATDAGNPIPRFPAGFLWGVSTSAHQIEGAADERESSVWDAFTAE
                     PGRVKDGSTAAVACDHYHRHREDVALLAGLGVNAYRFSVSWPRVRSEKGLDFYDRLVDD
                     LCAAGVRPVPTLFHWDLPADLDWLERDTAARFAEYVSLVAGRLGDRVTKWITLNEPAEH
                     TLLGHALGVHAPGRQLLFDALPAAHHQLLAHGLAVGALRASGATDIGIANSHGPTWAAS
                     TEAPDVEAAEFYDLLLNRLFADPLLLGRYPDGIGELMPGDVEADLKVIAEPLDWYGVNY
                     YAPTRVGAPQGTEIEFGGVRMPAELPFSVREIEGHPVTDFGWPVVPEGLTELLTTFHDR
                     YGDRLPPVVITENGCSYPGVDDRDRITYLDGHLRALHRAMEAGVDVRGYFVWSLLDNFE
                     WAEGYARRFGLVHVDFQTLERTPKASYAWFRDVLHAQTLRNATEES"
     misc_feature    9699..9714
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.45"
                     /tool="antismash"
     misc_feature    9705..9725
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 18.94"
                     /tool="antismash"
     gene            9778..9891
                     /db_xref="GeneID:91417331"
                     /locus_tag="CP976_RS14725"
                     /old_locus_tag="CP976_14765"
     CDS             9778..9891
                     /codon_start=1
                     /db_xref="GeneID:91417331"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF039305.3"
                     /locus_tag="CP976_RS14725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_14765"
                     /product="keywimysin-related RiPP"
                     /protein_id="WP_107092234.1"
                     /transl_table=11
                     /translation="MRTYERPTLTAVGSFRKTGLGFRAGPERFWFFRRRFF"
     CDS_motif       9778..9837
                     /prepeptide="leader"
                     /note="peptide class: lassopeptide"
                     /note="predicted sequence: MRTYERPTLTAVGSFRKTGL"
                     /locus_tag="CP976_RS14725_lassopeptide"
                     /aSTool="lassopeptides"
                     /tool="antismash"
     CDS_motif       9838..9891
                     /prepeptide="core"
                     /locus_tag="CP976_RS14725_lassopeptide"
                     /peptide="lassopeptide"
                     /predicted_class="Class II"
                     /score="-7.70"
                     /molecular_weight="2261.6"
                     /monoisotopic_mass="2260.2"
                     /core_sequence="GFRAGPERFWFFRRRFF"
                     /aSTool="lassopeptides"
                     /tool="antismash"
                     /leader_sequence="MRTYERPTLTAVGSFRKTGL"
                     /leader_location="[9777:9837](+)"
     gene            10001..11836
                     /db_xref="GeneID:91417332"
                     /locus_tag="CP976_RS14730"
                     /old_locus_tag="CP976_14770"
     CDS             10001..11836
                     /codon_start=1
                     /db_xref="GeneID:91417332"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010042088.1"
                     /locus_tag="CP976_RS14730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_14770"
                     /product="lasso peptide isopeptide bond-forming cyclase"
                     /protein_id="WP_150480774.1"
                     /sec_met_domain="Asn_synthase (E-value: 1.4e-38, bitscore:
                     132.5, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVDFPDSGEGPGWFVVLPDCASAGRVSAALRTRKVQEVTHPSGRP
                     WLLGRWSPGAMSVGEAGRAKVAVVGEHAMTADRLTRAAGRISAIAGLDGLARGMAGSSH
                     LVASISGRVRVQGSLTGFRRVFHARIGDTAVAADRADVLAALLDAEADEQWLAARLLNP
                     CAPHPLAGEPVWRDVSALGIGHYLALDADGRGRPVAWWAPPEPVVPMAEGASALREALS
                     AAVEVRVRGRDVVSCDLGGLDSTSVCALAAGGTAKVIAYTADGLDPLCDDVPWARRTVA
                     GLGGVDHHIIAGDQLPMVYEGLRDVDERFDEPCPAMMHPSRCLVIPRLAAAQGSGMHLT
                     GFGGDELFAGSPAHLHTLIRTHPRTALQRLRGFAAQGPWPYRETLRQLWDNTSYRAWLA
                     RAGDLLTAAPPPLEAPALDWGTPPRLPPWATPDAVEAVRELIRTAARTAEPLAERRGQH
                     IELEALGNNSRMVRQVGQLATRAGLTLAAPYYDDRVIEAGLAVRPQERITPWRYKPLIV
                     EAMRGIVPDESLTRHTKDEGSYEAEVGMREQRAELLALCEDSRLARLGLIDAKVLREMC
                     GGPLPPTLPFDALYQTVVCEMWLRTLETATTAVPG"
     aSDomain        11850..12095
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_CP976_RS14735_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="5.10E-21"
                     /identifier="RREFam002.1"
                     /label="CP976_RS14735"
                     /locus_tag="CP976_RS14735"
                     /protein_end="82"
                     /protein_start="0"
                     /score="65.5"
                     /tool="antismash"
                     /translation="MTFKLREGVFTAETDYGITLLDEERDQYWTLNPSAAIALRTLLHG
                     GTEADAARTLSEEYAVDIATAHRDVHELVGGLHSAGL"
     gene            11850..12230
                     /db_xref="GeneID:91417333"
                     /locus_tag="CP976_RS14735"
                     /old_locus_tag="CP976_14775"
     CDS             11850..12230
                     /codon_start=1
                     /db_xref="GeneID:91417333"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003990136.1"
                     /locus_tag="CP976_RS14735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_14775"
                     /product="lasso peptide biosynthesis PqqD family chaperone"
                     /protein_id="WP_150480775.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 1.5e-18,
                     bitscore: 65.5, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 2.1e-12, bitscore: 46.1,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTFKLREGVFTAETDYGITLLDEERDQYWTLNPSAAIALRTLLHG
                     GTEADAARTLSEEYAVDIATAHRDVHELVGGLHSAGLGEENTGGPEERAGTQRAPAPRP
                     GRRRAHGRWPRVLGRRPGRKSR"
     gene            12227..12700
                     /db_xref="GeneID:91417334"
                     /locus_tag="CP976_RS14740"
                     /old_locus_tag="CP976_14780"
     CDS             12227..12700
                     /codon_start=1
                     /db_xref="GeneID:91417334"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010042084.1"
                     /locus_tag="CP976_RS14740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_14780"
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_150480776.1"
                     /sec_met_domain="PF13471 (E-value: 1.2e-25, bitscore: 88.8,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSPEAIFHDPRSVPLRRRIPVRLAVGAARLLARRRPRRIRVVLE
                     WLRRGARPATLEQTRAARDSVVAVSLACGGREGCLPRSLATILLCRLHGQWPTWCVGAR
                     RLPPFGAHAWVEAEGVPVGETHPPDYFRPLFTVPCAPGPVSREAVIHEARSDG"
     gene            12678..14504
                     /db_xref="GeneID:91417335"
                     /locus_tag="CP976_RS14745"
                     /old_locus_tag="CP976_14785"
     CDS             12678..14504
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91417335"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003990138.1"
                     /locus_tag="CP976_RS14745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_14785"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_150480777.1"
                     /transl_table=11
                     /translation="MKPEATDETDERRRTAPWDFLRLLHGHRRWVALAVLLTLGASALS
                     LAQPLLVKQVIEATASGSAIGPALALLVVLFLAQALVQGLAQFVLARTGEGIVLGIRLG
                     LIKHVLRLPMAVYDRHRIGDLISRTSTDSTTLRLLVAEGFTEAVTGAIGLIGIVVLMVW
                     LDWLMFLVVLGMVAIATVIVVSVLHGIEVASLSTQRATGAMTADLERALGAIRTVRASR
                     AEQRETDRIAGGARSAYVGSVRMAKLDAVVAPAIQLAVKGSFVVVLLIGGIRVADRQGS
                     IADLAAFLLYMIYLVEPIGMLFQSLSTMEQGVGAYRRVTEVLELPTEQDAVPGAGAPAS
                     RPARGGEGRPRAAALEFRDVWFGYEPSRPVLRGVTFEAPEHCHVALIGSSGVGKSTVFA
                     LIERFYDPDRGHILFDGGDIQVIGRAEHRARVGLVEQHAPVLYGTLRENLTYSVPDAGP
                     EELDRVVELAHLTDLIARLPRGLDTDAGEHGMALSGGERQRIAIARALLARPRLLLLDE
                     PTAHLDAVSEAALRRSMRETARECTLLVIAHRMSTIRAADLIVVLDAGRVVATGSHGDL
                     LDSSEHYRSLIRAQQTGDLRVPRTAGLKGATG"
     gene            complement(14548..15510)
                     /db_xref="GeneID:91417336"
                     /gene="era"
                     /locus_tag="CP976_RS14750"
                     /old_locus_tag="CP976_14790"
     CDS             complement(14548..15510)
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91417336"
                     /gene="era"
                     /gene_functions="other (smcogs) SMCOG1227: ribosome
                     biogenesis GTP-binding protein YsxC"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003976264.1"
                     /locus_tag="CP976_RS14750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_14790"
                     /product="GTPase Era"
                     /protein_id="WP_150480778.1"
                     /transl_table=11
                     /translation="MGAMSVRTQSSEKPAEAVHRAGFACFVGRPNAGKSTLTNALVGQK
                     VAITANQPQTTRHTVRGIVHRSDAQLILVDTPGLHKPRTLLGERLNDIVRTTWAEVDVI
                     GFCLPANEKLGPGDRFIAKELASIKKTPKIAIVTKTDLVDSKTLAEQLIAIDQLGKELG
                     FEWAEIVPVSAVGDKQVGLLADLIVPLLPEGPALYPEGDLTDEPEQVMIAELIREAALE
                     GVRDELPHSIAVVVEEMLPREDRPADKPLLDIHAFVYIERPSQKGIIIGPKGKRLKEVG
                     IKSRKQIEALLGTPVFLDLHVKVAKDWQRDPRQLRKLGF"
     gene            15692..16030
                     /db_xref="GeneID:91417337"
                     /locus_tag="CP976_RS14755"
                     /old_locus_tag="CP976_14795"
     CDS             15692..16030
                     /codon_start=1
                     /db_xref="GeneID:91417337"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018850023.1"
                     /locus_tag="CP976_RS14755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_14795"
                     /product="P-II family nitrogen regulator"
                     /protein_id="WP_086847395.1"
                     /transl_table=11
                     /translation="MKLITAIVKPYRLDEIKNALQELGVHGLTVSEASGYGRQRGHTEV
                     YRGAEYQVDLVPKIRIEVVVDDADAEAVIDAVVKAAHTGKIGDGKVWALPVDTVVRVRT
                     GERGPDAL"
     gene            complement(16052..16528)
                     /db_xref="GeneID:91417338"
                     /locus_tag="CP976_RS14760"
                     /old_locus_tag="CP976_14800"
     CDS             complement(16052..16528)
                     /codon_start=1
                     /db_xref="GeneID:91417338"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010042073.1"
                     /locus_tag="CP976_RS14760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_14800"
                     /product="hypothetical protein"
                     /protein_id="WP_150480779.1"
                     /transl_table=11
                     /translation="MRCKRTGAGAALAAGALAVTGLAFAPAALAVTPQTATISADCGTF
                     GSGEATLTATQDGTAATLTVKSSAITAPIALGEDSIASTLSLVKAGGGTVDFTGTQNPA
                     MAAGAPVEVGPLSGTVASGDSLEAFGGSLKMTVFGITITCTATGPQSPGPFVFD"
     gene            complement(16700..17053)
                     /db_xref="GeneID:91417339"
                     /locus_tag="CP976_RS14765"
                     /old_locus_tag="CP976_14805"
     CDS             complement(16700..17053)
                     /codon_start=1
                     /db_xref="GeneID:91417339"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007381927.1"
                     /locus_tag="CP976_RS14765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_14805"
                     /product="cytidine deaminase"
                     /protein_id="WP_150480780.1"
                     /transl_table=11
                     /translation="MTDSSALDPEDRKIVTLARSARARNGVPEGAAVRDETGRTYVAGT
                     VALDSLKLTALQTAVAMAVASGAKSLEAAAVVTEAETASDEDRAAVRDLGGAQTPVLVA
                     GPDGTVRTTVTAG"
     gene            complement(17074..17433)
                     /db_xref="GeneID:91417340"
                     /locus_tag="CP976_RS14770"
                     /old_locus_tag="CP976_14810"
     CDS             complement(17074..17433)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91417340"
                     /gene_functions="other (smcogs) SMCOG1198: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014672631.1"
                     /locus_tag="CP976_RS14770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_14810"
                     /product="MmcQ/YjbR family DNA-binding protein"
                     /protein_id="WP_150480781.1"
                     /transl_table=11
                     /translation="MTPQELRAFCLSFNAAVEDFPFSPEISVFKVQGKLFALSHLDARP
                     LKVNLKCDPDDAIRLRHEHEGLIVPGWHMNKRHWNTVTCDGGLPDRLVRELVEDSYDLV
                     VAGLPRADRLRLDRP"
     gene            complement(17430..18734)
                     /db_xref="GeneID:91417341"
                     /locus_tag="CP976_RS14775"
                     /old_locus_tag="CP976_14815"
     CDS             complement(17430..18734)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91417341"
                     /gene_functions="other (smcogs) SMCOG1273: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003990145.1"
                     /locus_tag="CP976_RS14775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_14815"
                     /product="hemolysin family protein"
                     /protein_id="WP_150480782.1"
                     /transl_table=11
                     /translation="MSPQLALGAVALVVVAWLFACAEAGLARVSSFRAEEAVRSGRRGS
                     AKLSQVAADPTRYLNVALLVRVACEMAAAALITYGCLMEFDNTTEALLIAIAVMVLVSY
                     VAVGVSPRTIGRQHPLNTATVSAYVLVPLARVMGPIPSLLILIGNALTPGKGFRRGPFA
                     SEAELRALVDLAEKESLIEDDERRMVHSVFELGDTLVREVMVPRTDLVVIERYKTIRQA
                     LTLALRSGFSRIPVTGESEDDIVGIVYLKDLVRKTHISRDAESEQVSTAMRPAFFVPDT
                     KNAGDLLREMQKERNHVAVAVDEYGGTAGIVTIEDILEEIVGEITDEYDRELPPVEDLG
                     KDRYRVTARLDIGDLGELYGLEAFDDEDVETVGGLLAKALGRVPIAGASSVVELPDGRE
                     LRLTAEAAAGRRNKIVTVLAEPVDPADPVEEEKPE"
     gene            complement(18743..19240)
                     /db_xref="GeneID:91417342"
                     /gene="ybeY"
                     /locus_tag="CP976_RS14780"
                     /old_locus_tag="CP976_14820"
     CDS             complement(18743..19240)
                     /GO_function="GO:0004540 - RNA nuclease activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0042254 - ribosome biogenesis [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91417342"
                     /gene="ybeY"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003957737.1"
                     /locus_tag="CP976_RS14780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_14820"
                     /product="rRNA maturation RNase YbeY"
                     /protein_id="WP_150480783.1"
                     /transl_table=11
                     /translation="MSIDVNNESGTEVDEQAILDIARYALARMRIHPLSELSVIVVDAA
                     AMEQLHIQWMDLPGPTDVMSFPMDELRPPSKDDDEPPQGLLGDIVLCPEVAQKQGKEAD
                     TQHSMDEELQLLTVHGVLHLLGYDHEEPDEKAEMFGLQAAIVDGWRAERGLTGPSPAPT
                     VS"
     gene            complement(19254..20321)
                     /db_xref="GeneID:91417343"
                     /locus_tag="CP976_RS14785"
                     /old_locus_tag="CP976_14825"
     CDS             complement(19254..20321)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91417343"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004988313.1"
                     /locus_tag="CP976_RS14785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_14825"
                     /product="PhoH family protein"
                     /protein_id="WP_150480784.1"
                     /transl_table=11
                     /translation="MTQTPTAHTPAQEQARAQFTVPAQHPMVTVLGSGDALLRVIEKAF
                     PAADIHVRGNEISAVGDPVDVALIARVFDEMMLVLRTGQPMTEDAVERSIAMLKASENG
                     ESDGQETPAQVLTQNILSSRGRTIRPKTLNQKRYVDAIDKHTIVFGIGPAGTGKTYLAM
                     AKAVQALQSKQVNRIILTRPAVEAGERLGFLPGTLYEKIDPYLRPLYDALHDMLDPDSI
                     PRLMAAGTIEVAPLAYMRGRTLNDAFIILDEAQNTSPEQMKMFLTRLGFDSKIVITGDV
                     TQVDLPEGTKSGLRQVQDILDGVEDVHFSRLSSHDVVRHKLVGRIVDAYEQYDTKHGTQ
                     NGAHKGRGKSGHKGK"
     gene            complement(20499..21635)
                     /db_xref="GeneID:91417344"
                     /locus_tag="CP976_RS14790"
                     /old_locus_tag="CP976_14830"
     CDS             complement(20499..21635)
                     /codon_start=1
                     /db_xref="GeneID:91417344"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1276: PfkB domain protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010042061.1"
                     /locus_tag="CP976_RS14790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_14830"
                     /product="PfkB family carbohydrate kinase"
                     /protein_id="WP_150480785.1"
                     /transl_table=11
                     /translation="MIASTAPAGKGPAGKGSHRQTQVDPLAPLRAPDDPPWDVYLTGTV
                     FLDIIFTGLDSAPVRGTESWARGMGSSPGGVANMATALARLGLRTSLAAAFGDDHYGDY
                     CWDALEHGEGIDLSPSRTVPGWHSPVTVSMAYEGERTMVSHGHEPPPEEPAPECPPRAR
                     AAVASLAPGVSAPWIAQAASKGTRVFGDVGWDDTGAWDLAALPDLRHCEAFLPNAEEAM
                     RYTGADCPRAAAHALTEHVPLAVVTLGADGAYAVDRRTGETAEVPAIEVEALDPTGAGD
                     VFVAGFVTGTLADWPLADRLAFAGLTAALSVQEFGGSLSAPGWSEIAAWWRRVQSVEGQ
                     SAVALERYGFLADLVSEELVRPWPLRRAVPTIGFRRSA"
     misc_feature    complement(21691..21706)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.38"
                     /tool="antismash"
     misc_feature    complement(22223..22236)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.11"
                     /tool="antismash"
ORIGIN
        1 aggcattccg ggccgccggt ctccggtgcc gagggactgc gcaggaaccg ctcgatcagc
       61 cgtgccgtgg gcccgggcga cagcagggac tccccggccg cgaccgtacg gatggcgtcg
      121 aggagttcgg ccggcctggt gtccttcacc aggaacccgg aggccccggc gcgcagcgcg
      181 tccacgatgt tctcgtcggt gtcgtaggtg gtgagcacca ggacgcggac gcccgcgagg
      241 tcctcgtcgg ccgcgatgag ccgggtcgcc tcgatgccgt ccaggtcggg catgcggatg
      301 tccatcacca cgaggtcggc gcgctcgctg cgggccagcc gcacggcctg ccggccggtg
      361 gcggcctggc cgacgacctt catgtcccgg gccgactcca cgagcatcgc gaacgcctcc
      421 cgcaccagcg tctggtcgtc cgcgagcagc actcggatgg tcatccggct ctctcccccg
      481 tcgtcagcgg caggaccgcg gtcacctcga acccgccccc ggtgcgcggt ccggcgtcga
      541 gtgtgccacc gacgctgcgg gcccgctccc gcattccgac gagcccgaac cccggggtgc
      601 cgcccggtgc cggtccggtg ccgtcgtcgc tgaccgtcag gtgcagagca ccctgccgct
      661 cgtccaggtc gacacggacg gccggttcgg gtcccgcgtg ccgtaccgcg ttggtcagcg
      721 cctcctgcac gatgcggtag gcggcggcac cgacggcggg cggtgcctgc cgtatccgta
      781 cggtctgctc gacccgggca ccggcgagcc gcgcggcctc cgccaggtcg gtcagaccgt
      841 cgaggccggg cagcggacct cgggcatccg gggaatcgtg ctcgcgcagc acctccagcg
      901 tcgtacggag ttcgccccgg gcgctgcgac aggtctcggc gatgtcgtcc agcgccttgg
      961 ccaccgtctc ccggtcgagc cgctcggggt cggcggacag cacgtgggcg gcgacggaag
     1021 tctgcacgcc gatgagggtg atgctgtgcg cgagcaggtc gtgcaggtcc cgggcgatcc
     1081 gcaaccgctc ctcggcgacc cgccgccggg cctcctcctc gcgggtgcgc tcggcacgtt
     1141 cggcgcgttc cacgatggag gcgacgtact ggcggtagaa gcgcacgtcc gcaccgcaga
     1201 acagcacggc gacgacccac ccggagatct ggagcacctt cagcgcctcg tgcatgctca
     1261 cggtgagcat cacgctcgtc gagagggtga tgacgccgac gccgaccagg acggtacgca
     1321 gcggccgtcc ggtgacggcg acggtgtaga gggcgatgta ggtggccggg gtcggcgccg
     1381 tgtgggtgtt gtcgagggcg tggtagggcg cgacgcaggc cacgatcgcg agcagcacga
     1441 gcagcggacg gcggcgccgc cacgccagcg gcacgtggca ggcgagcagc agcgtccagc
     1501 cgagcgcgtc gggccggcgg ccgtcgtcga cgaacagcgc gagtccgacc gccagtacgg
     1561 cggcgacgac agcgagcagc gcgtcgttgc gcacggcgtg cggagcggtc agcggatcac
     1621 ggttgatcac cgccatgatc cgattacctg tcgtgggcac ctgcacggac ctcatcctcg
     1681 tccaggaatg cgcccctccg ggaggggagg ggcgcttgat ctgctcagcg cgacgcaggg
     1741 ctgcgcaccc gcccctgttc ggctccggca ggctgctccg gtgcacgcga gagccgaccc
     1801 ggccaccaca tccgccgctt cagcagcaca ctcgccgtgg tgaccaagta cgtccgcaca
     1861 aggaaggtgt ccagcagcac ccccaccgtg atgacgaacc cgagctcgac gagcccgacc
     1921 aacggcagcg tcgtcagtac cgcgaacgtc gccgcgagca ccacccccgc cgaggcgatg
     1981 accccaccgg tcgtacgcaa cgcggtcagc gccgcggcct ccggttcggc acccttcacc
     2041 gactcctccc gcatccggtg catgaggaag atgccgtagt cgaccccgag ggcgaccagg
     2101 aacacgaacg acagcagccc cagtccggga tccgtaccgc cgaagccgaa caccggctcg
     2161 aacaccagcc ccccgatgcc gagggccgca ccccacaccg ccaccacggc cgccagcagc
     2221 agcaacggcg cgacgagact ccgcaacagg ccgaccagga tgacgaacac ggcgcccagc
     2281 accagcggca cgatcacctt gcggtcccgc gactcgctgt cggccaggtc gatctgctgc
     2341 gcgctgggcc cgccgacgta ggcgcccgcg gtgtcgagcc cggtacgcag ggcttcgatg
     2401 gtccgcgtct cggccggagt ctcgggcgag gcagccgtga agaccgcgat ctcggtccac
     2461 cccgagccac tgcgcccggg aaccgcctcg gcgacaccct cggtctcacg ggcccggtcc
     2521 aacaccacgt cggtccgctc gtcgggggcg atgacggtca ccggccggct gctgcgctcc
     2581 ggatactccc gcgccagcgt ctgcatggcg gtgatggact cgggccgttc ggtgaaggag
     2641 tcctcctgct tgatgctgcc ggacaggttg agcgtgccca gcgcgagcgc accgagcagg
     2701 acgccgccac cgacgagcac ggtgacgggc cggcgcgtcg ccgaggtccc catcgcggcg
     2761 aacagcgacc gccgggcctt gggctcactg ccgaaggcgg ggatcagcgg ccagaagacc
     2821 cgccgcccga gcagcacgag cacggcgggc agcagggtcg tcatggcgac cagcgccgcg
     2881 agtacgccga ccgtgccgac cggccccatg ccgctgctgc tgttgagatc ggcggcgagc
     2941 aggcacagca gcccggccgc gacggtcccg gaggaggcga ggatggccgg tccgcagccg
     3001 cgcagagcgg tgcgcatggc gtcgtacggc cgctcgtggc gccgtagttc ctcgcggtag
     3061 cgggcgatga gcagcagcgc gtagtcggtg ccggcgccga ggacgagcac ggtcatcacg
     3121 ccgccgctct ggccggtgac ggtgacgtcg aacagttcgt ggagtccata cccggcggcc
     3181 atggccgtgg tggcggcgac gcccgcgacg gcgagcggca ccagccacag gaacgggctg
     3241 cggtagatca ggatcagcag gacggtgacg acggcgagcg tggccagcag cagggtgccg
     3301 tcgatcgtct cgaacacctt gcccatgtcg gtgttcagcg cccccggccc gccgacctcg
     3361 acgctcagcc cgccgctccc ctcggcgacc tcgcgcacgc cgtccacgaa ggcgttccgg
     3421 gcctcctcgt cctggcccgg ctgggtgctg gacaccgggt acatcagggt ggagccgtcc
     3481 tcggacggca cgccccgcgg ctcgccggtc acgtcgtagg cgccgcgcac ctcggcgatc
     3541 tgctcggcgg ccgtgcgccg gtcggcgtcg gtcaggccgc cgtcccggtg gtacacgagc
     3601 accaggtcgg tggactcgcc ccccgggagc cggtcctgga tccgcgcgac ctgcgtggag
     3661 tcggcgctgt cgggcaggta gtcgaccgcg cggttctgct ggatgccggc gaacttcccg
     3721 gcgagcggcc cgaccagtac gagggcggcg agccacagcc cgaccaccgc ccagggcacg
     3781 gctcgccgcc gtgcggtgtt ccttgtgtcc cccactgttc gggctccctc cggtccgggt
     3841 gtctggaacg gtctccagac tcccggcgca cgggggcgga ttcgtcgggc tcgaggccga
     3901 gtcgggggtt actgcacagg gcggcacggg ctgcggatta ctccccgggg agtaacggcc
     3961 ccgggtcggc cgggaagggg ctgcgcccta cgacggcgtg cgcgccgccg ccgccatcac
     4021 ccgtgtcacg tcgtccgaac agatggtgag cgccgccccc accgtggcga gcacgtcccg
     4081 ctcggccggg gtgtacggcc cgtccgccag ggcgatgcgc gccccctgga gcaggatcga
     4141 ttcgcggccg accgtggcga ggtgcggggc gagcgggtcc agcgcctcgt gcagctctat
     4201 ggccagcccc gcaccgcagg gctccccggt gatccggccg gtgtccgcct ccagcgcctc
     4261 cacgagggcg gccagttgct cctccgtgca gtcgtcgaag ccggccgcgc gcacggcgag
     4321 caccgcggac tccagcgccg tacgggaacc ggcgccgccc gcggccagca cggcgagggc
     4381 gacggtgtgc acggcgtcgc ggagcatcgc ggagaagcgg gtggtggtcg gatggtcgag
     4441 gacgtccatg ccgaagtggc ggcggcaggc ggcgcactcc acgaccgggc cggtctcgcc
     4501 gcgcggcagc acgggcaggc cgagcagggt gaagcggcgt tgtccggtca gccgctggta
     4561 gttgcggtcg ccgccgcagc cggggcagaa gaactctccg tcaccggcgg gcgtccacgc
     4621 ggtacgggtg cccaggatgc ccgacaacct ggcggcatgg ccgtttcgtc cccgtcctgg
     4681 cagcacgtcg cacctccgtc atgccgcacg gcagcgtcgc cgcgcttgcg tgatgttagc
     4741 cacatccatg aggaggagtc agcaccccgg aggagacctt tccgtgaccc tcacagggat
     4801 tggccggtat gcgacggggc tccgaccgcc ggacatcagc ggacggagcc ctcaaaccgc
     4861 ctacggggct ggtcagcgag tcgcgcggtt gacggccgag acgaccgcct tcagcgaggc
     4921 gcgcgtggtg ttcgcgtcga ttccgatccc ccacaggacc ttgtcgccga tcgcgcattc
     4981 gatgtaggag gcggcctgcg cggaggcacc ctcgctcatc gtgtgctcct ggtagtccag
     5041 caggcgtacg tcgatgccga cggactggag cgcgtcgaag aaggccgaga tcggaccgtt
     5101 gccggaaccg gtcaggacgg tgtcctggcc gtcgaccgtg gcctcgaccg tcagcgtgtc
     5161 cactccgtcg gtgtcggtcg tcgactggtt gttcttgacc tggatccggc cccacgggtt
     5221 ctcggggttg ggcaggtact cgtcccggaa ggccgcccag atgtccttcg gcgtgacctc
     5281 gccgccctcg gcgtcggtct tcgcctggat gagcttggag aactcgatct gcatccggcg
     5341 gggcagttcc agcttgtggt cgttcttcag gacgtacgcg atgccgccct tgccggactg
     5401 cgagttgacc cggatgacgg cctcgtagga gcggccgacg tccttggggt cgatcggcag
     5461 gtacgggacc gcccactcga tgtcgtcgac ggtgacgccc ttggcggccg cgtcggcctc
     5521 catcgcgtcg aagcccttct tgatggcgtc ctggtgggag ccggagaagg acgtgtagac
     5581 caggtcgccc acgtacgggt ggcgcgggtg gacctccatc tggttgcagt actcccacgt
     5641 gcggcggatc tcgtcgatgt cggagaagtc gatctgcggg tcgacgccct gggagaagag
     5701 gttcatgccc agggtgacca ggtcgacgtt gccggtgcgc tcgccctgcc cgaacaggca
     5761 gccctcgaca cggtcggcgc cggccatcag ggccagctcg gcggcggcga cggccgtgcc
     5821 gcggtcgttg tgcgggtgga tcgacaggca gacgtgctcg cggcgggaga ggttgcggcc
     5881 catccactcg aagcggtccg cgtgggtcga cggggtcgaa cgctccaccg tggcgggcag
     5941 gttgaggatg atctcgcgac ccgggccggg ctgccagacg tccatgaccg cctcgcagac
     6001 ctccagcgcg aagtccagct cggtgtcggt gaagatctcc ggcgagtact ggtagccgaa
     6061 ctccgtctcc gggcccagca gtttctccgc gtactccatg accagccgcg tgccgtcgac
     6121 ggcgatctgc ttgatgtcgt ccttggagcc ccggaagacg acccggcgga agacgggggc
     6181 ggtggcgttg tagaggtgga cggtcgcgcg cctggcgccc ttcagcgact ccaccgtgcg
     6241 ctcgatcagg tcctcgcggg cctgggtcag tacggagatg gtgacgtcgt cggggatggc
     6301 accgggctct tcgatgatgg agcgtacgaa gtcgaagtcg gtctggccgg aggccgggaa
     6361 gccgacctcg atctccttgt agcccatctt gaccagcagg tcgaacatcg cgcgcttgcg
     6421 ggcgggcgac atggggtcga tcagggcctg gttgccgtcg cgcaggtcgg tggagagcca
     6481 gcggggggcg gtggtgatgc gcttgtccgg ccacgtgcgg tccgggatgt cgacctgctc
     6541 gtagcggccg tacttgtgga tcggcatgga actgggctgc tggcggttcg ccataatgcg
     6601 ggggctcctc aggaggtgtc cggaaggacg gccgacgacg cagcaccaag ctccgcgggg
     6661 agggagtcgg cctcgactac aggccctcgc cgcggcagct aaggagaagc agcccgaaac
     6721 gcatgatgcg cagcatgcta gtcgagactc tccgtgtgcg cggatccgta tcagtatgcg
     6781 ggaccggacg cgcaaacggg acaaaaagtg cgctatacca cttcgccacg gagggtgaag
     6841 gtccttgtcc cggtatttca ccaatcatgg tggctactgg tgacagtctc gtcacgcagt
     6901 gcaaaggtgc cgggcatgac gactcacggg ggcttcgagc ccgtcttctg caccatcgtt
     6961 ccgccccacg tcctcgacaa gctctcccag gccgaggacc ccgcactcgc cgggcccgcc
     7021 cgccggacac tggagcgcga cgccctggag cgcacccacc gccgcctgac cacggtcgtc
     7081 ggcgccccgt ccgtggcccc gcccgccggg gccgagcccg ccaggccgca ccgcacggtc
     7141 cacgacgccc ggcacggcac ggacctgccc ggacacaagg tgcggggcga gggcgacaag
     7201 cccggcaagg acgccaccgt caaccgcgcc tacgccggcc tcggcgccac cttcgagctg
     7261 ctcctgaagg cgtaccggcg cgactcgatc gacggcaacg gtcttcccct ggacgcgacc
     7321 gtgcactacg accgcgagta caacaacgcc ttctggaacg gcgagcagat ggtcttcggc
     7381 gacggggacg gcgagatctt cctcgacttc accatcccga tcgacgtcat cggccacgaa
     7441 ctcgtccacg gcgtcacgca gtacacggcc aacctcacct acttcggcca gcccggcgcg
     7501 ctgaacgagt ccgtgtcgga cgtcttcggc tcgctcatca agcagtacac gctcggccag
     7561 accgccgccg aggccgactg gctgatcggc gcgggcctgc tcgccccgcg ggtgacgggc
     7621 aaggcactgc gctccatgaa ggagccgggc acggcgtacg acgacgacgt cctgggcaag
     7681 gacccccagc cggcgacgat ggacgacttc gtccgcaccg gccgcgacaa cggcggcgtc
     7741 cacatcaact cgggcatccc gaaccacgcc ttctacctgg cggccacggc cctcggcggc
     7801 cacgcctggg agcgcgcggg actgatctgg tacgacgtgc tgaccggcgg cgagctgaag
     7861 cagcaggcga tgttcgccga cttcgccacg ctcaccgtca aggccgcgcg ggagcggttc
     7921 ggcgacgggg aggagctgga ggccgtgtcg aaggcctggg agcaggtcgg ggtgcggacc
     7981 ctgtagttcc gtactagaca ggtgccatgc gtattcaggt gaggcgcacg ggcgggttcg
     8041 cgggcatcga gcggcatgcc gaggtggaca cctccggccg ccccgatgcc cccgaatggc
     8101 acgcgctggc cgagcaggcg gtcgccgccg gccggagcac gccgccgatc ggggttccgg
     8161 acgggttcag ctaccagatc accgtggacg ggaagacggt gtacgcggcc gacccgcgac
     8221 tgacggacga gcagcggaag ctgatctcgc gggtgctgaa ggaaggtgct taacaggtct
     8281 tccgcagcgg cctgttgact tccgttaccg gcggtacgga tgatccagcg catggcgact
     8341 gacgcaggca atccgatccc ccgcttcccg gccggcttcc tctggggcgt gtcgacctcg
     8401 gcgcaccaga tcgagggggc cgcggacgag cgcgagtcgt ccgtgtggga cgccttcacc
     8461 gccgagccgg gccgggtgaa ggacggctcg acggcggcgg tggcctgcga ccactaccac
     8521 cgccaccgcg aggacgtggc cctgctcgcc ggcctcggcg tgaacgccta ccgcttctcg
     8581 gtctcctggc cccgggtgcg ctccgagaag ggcctggact tctacgaccg gctggtggac
     8641 gacctgtgcg cggcgggcgt ccgcccggtg ccgaccctgt tccactggga cctgccggcg
     8701 gacctcgact ggctggagcg ggacacggcc gcgcgcttcg ccgagtacgt ctcgctggtc
     8761 gccggccgcc tcggggaccg ggtgaccaag tggatcaccc tcaacgagcc cgccgaacac
     8821 accctgctgg gccacgccct gggcgtccac gcaccgggca ggcaactgct gttcgacgcg
     8881 ctcccggccg cccaccacca gctgctggcc cacggcttgg ccgttggggc cctgcgcgcc
     8941 tccggcgcca cggacatcgg catcgccaac tcgcacggcc cgacctgggc ggcgtccacc
     9001 gaggcgccgg acgtggaggc ggccgagttc tacgacctgc tgctgaaccg cctgttcgcg
     9061 gacccgctgc tgctgggccg gtacccggac ggcatcggcg agctgatgcc cggggacgtc
     9121 gaggccgacc tgaaggtgat cgccgagccg ctcgactggt acggcgtcaa ctactacgcc
     9181 ccgacccggg tgggcgcccc gcagggcacg gagatcgagt tcggcggtgt ccgcatgccc
     9241 gccgaactcc ccttctccgt acgggagatc gagggccacc cggtcacgga cttcggctgg
     9301 cccgtcgttc ccgagggcct caccgaactc ctcaccacct tccacgaccg ctacggcgac
     9361 cgcctcccgc ccgtcgtcat caccgagaac ggctgctcgt acccgggcgt cgacgaccgg
     9421 gaccgcatca cctacctgga cggccatctc cgggccctgc accgggcgat ggaggcgggc
     9481 gtcgacgtgc gcggttactt cgtgtggtcc ctgctcgaca acttcgagtg ggcggagggc
     9541 tacgcacgcc gcttcggact ggtgcacgtc gacttccaga cgctggagcg gactcctaag
     9601 gcgtcgtacg catggttccg cgatgtactg cacgcacaaa ccctgcgaaa tgccactgaa
     9661 gaatcctaaa tattgaacca ataaccatat ctcacctttt gggcatttgg tcgattcggc
     9721 gtctactgtg gaagagacaa ccgatagcga cgcgcgcagt tcaggaggtg caacgacatg
     9781 cgcacctacg agcgtccgac gctgactgcg gtcggctcct tccgcaagac cggtctgggc
     9841 ttcagggctg gaccggagag gttctggttc ttccggagga ggttcttctg atccgccggt
     9901 tgtctcaccg gcgcgggacc tccagatggc ggcagggcgc aggtcctgcc gcccctatgt
     9961 cttgatcacc tcgtggctgg gcgtacggga agggaccggc atggtcgatt ttcctgattc
    10021 cggcgagggg ccgggctggt tcgtcgtcct tccggactgt gcttcggcgg gccgggtgtc
    10081 cgccgcactg cgcacccgga aggtccagga ggtcacccac ccgtcaggac ggccgtggct
    10141 gctcggccgc tggtctcccg gtgccatgtc cgtcggcgag gccggccggg cgaaggtcgc
    10201 ggtcgtcggt gaacacgcca tgaccgccga ccggctcacc cgggcggccg gccggatcag
    10261 tgcgatcgcc ggtctggacg gtctggcccg tggcatggcc gggagttctc atctggtcgc
    10321 ctcgatcagc ggacgggtgc gtgtccaggg gagcctcacc ggctttcggc gggtgttcca
    10381 cgccaggatc ggtgataccg ccgtggccgc ggaccgggcc gacgtcctgg ccgctctgct
    10441 cgacgcggag gccgacgagc agtggttggc ggcccgcctg ctgaatccgt gcgcgcccca
    10501 cccgctggcc ggcgagccgg tctggcgcga cgtgagcgcc ctggggatcg gccactacct
    10561 ggcgctcgac gccgacggcc ggggacggcc cgtggcgtgg tgggcgcctc cggagccggt
    10621 ggtgccgatg gccgagggcg cgtcggcgtt gcgggaggca ctgtcggcgg cggtggaggt
    10681 ccgcgtccgg ggccgggacg tggtgagctg cgatctgggc gggctggact cgacctcggt
    10741 gtgtgctctg gccgcaggcg gcacggcgaa ggtcatcgcc tacaccgccg acggcctcga
    10801 ccccctgtgc gacgacgtgc cctgggctcg ccggacggtt gcgggactcg gcggcgtcga
    10861 tcaccacatc atcgccggcg accagttgcc gatggtgtac gagggccttc gggacgtgga
    10921 cgagcgcttc gacgagccgt gcccggccat gatgcatccc agccgctgcc tggtcattcc
    10981 acggttggcc gcggcacagg gctccggtat gcacctgacg ggcttcggcg gggacgagct
    11041 gttcgccggt tcgccggcgc atctgcacac gctgatacgc acacacccca gaaccgcgtt
    11101 gcagcgcctg cgtggcttcg ccgcccaggg tccgtggccg taccgggaaa cgctgcggca
    11161 gctgtgggac aacacctcct accgggcgtg gctggcccgg gccggcgacc tgctcaccgc
    11221 cgcaccgccc cccttggagg cgcccgcgct ggactggggg acgccaccgc ggctccctcc
    11281 ctgggcgacg ccggatgccg tcgaggccgt acgggagctg atccgcacgg cggcgcgtac
    11341 cgccgaacca ctggccgagc ggcgcggaca gcacatcgag ctggaagccc tgggaaacaa
    11401 ttcccgcatg gtccggcagg tgggtcagct ggccacccgc gccgggctca ccctcgccgc
    11461 cccctactac gacgaccgcg tgatcgaagc gggcctggcc gtgcggccgc aggaaaggat
    11521 cacgccctgg cggtacaagc cgctcatcgt cgaggcgatg cgcggcatcg ttcccgacga
    11581 gagcctgacc cgccacacca aggacgaggg ttcctacgag gcggaagtcg ggatgcggga
    11641 gcagcgtgcc gagttgctgg ccctgtgcga ggactcccgg ctggcccgcc tgggtctgat
    11701 cgacgcgaag gtgctgcgcg agatgtgcgg tgggccgctg cccccgaccc tgccgttcga
    11761 cgcgctgtac cagaccgtgg tgtgcgagat gtggctccgc acgctggaaa ccgccaccac
    11821 cgccgttccg ggctgaaggg agagggccga tgaccttcaa gctgcgtgag ggtgtgttca
    11881 cggccgagac ggactacggg atcacgctcc tcgacgagga gcgcgaccag tactggacgc
    11941 tcaatcccag cgccgccatc gccctgcgaa cgctgctgca cggcggcacg gaagccgatg
    12001 ccgcgcggac gctcagcgag gagtacgcgg tggacatcgc caccgcgcac cgggacgtcc
    12061 atgaactggt cggcggactg cactcggcgg gcctgggcga ggagaacacc ggcgggccgg
    12121 aggagcgcgc cggaactcag cgggccccag cgccgcggcc ggggcggcgc cgggcgcacg
    12181 gccgatggcc gcgcgtactc ggccggcggc cggggaggaa gagccgatga cctcaccgga
    12241 ggcgatcttc cacgaccctc gctcggtgcc cctgcggcgc cggatcccgg tccggctcgc
    12301 cgtgggcgcc gcacggcttc tggcccgccg gcgcccccgg cgcatccggg tcgtactgga
    12361 gtggctgcgc cggggcgccc gtccggccac cctcgaacag acccgggccg cccgggactc
    12421 cgtggtcgcg gtcagcctgg cgtgcggggg acgggagggg tgcctgcccc ggtccctggc
    12481 cacgatcctg ctgtgccgcc tgcacggcca gtggcccacc tggtgcgtgg gcgcacggcg
    12541 cctgccgccc ttcggtgcgc acgcgtgggt ggaggcggag ggggtgccgg tgggagagac
    12601 ccacccgccc gactacttcc gccccctgtt caccgtgccc tgcgctcctg gtcccgtcag
    12661 ccgtgaggcc gtgatccatg aagcccgaag cgacggatga gaccgacgag cggcgccgga
    12721 ccgccccgtg ggacttcctg cgcctgctgc acggccaccg gcggtgggtc gccctcgccg
    12781 tcctgctgac gctgggagcc tctgccctga gcctggccca gccgctgctg gtcaagcagg
    12841 tgatcgaggc gaccgcgtcc ggcagcgcga tcgggcccgc cctggcgttg ctcgtcgtcc
    12901 tcttcctggc ccaggcactg gtgcagggcc tcgcccagtt cgtgctggcc cgcacgggcg
    12961 aagggatcgt gctggggatc cggctcggcc tgatcaagca cgttctgcgg ctgcccatgg
    13021 ccgtctacga ccgccaccgc atcggcgatc tgatctcgcg caccagcacc gacagcacga
    13081 ccttgcggct gctcgtcgcg gagggcttca ccgaagcggt gaccggggcc atcgggctga
    13141 tcggcatcgt ggtgctgatg gtctggctcg actggctgat gtttctcgtc gtgctgggca
    13201 tggtggcgat cgccaccgtg atcgtcgtct cggtgctgca cggcatcgag gtggcgtcgc
    13261 tgtccacgca gcgggcgacg ggcgcgatga ccgctgatct ggagcgcgcg ctcggtgcca
    13321 tccgcaccgt ccgggccagc cgcgccgagc agcgtgagac cgaccgcatc gcggggggcg
    13381 ccaggtcggc ctacgtgggc agcgtgcgga tggcgaagct ggacgccgtg gtggcaccgg
    13441 cgatccagct ggccgtcaag ggatcgttcg tcgtcgtgct gctcatcggc ggcatacggg
    13501 tcgccgaccg gcaggggtcg atcgccgatc tcgcggcctt cctgctgtac atgatctacc
    13561 tggtggagcc gatcggcatg ctgttccagt ccctcagcac catggagcag ggcgtgggcg
    13621 cgtaccgcag ggtcacggaa gtgctggagc tgcccacgga gcaggacgcc gtgccgggcg
    13681 ccggggctcc ggcgtcccgc ccagcgcgtg gcggcgaagg caggccacgg gcggccgcgc
    13741 tggagttccg cgacgtgtgg ttcggctacg aaccgtcacg ccccgtcctg cgcggcgtga
    13801 ccttcgaggc gccggagcac tgccatgtcg ccctgatcgg cagctcggga gtcggcaagt
    13861 ccaccgtctt cgcgctgatc gagcggttct acgacccgga ccgcggccac atcctcttcg
    13921 acggcggtga catacaggtg atcggccgag ccgaacaccg ggcccgggtc ggcctggtgg
    13981 aacagcatgc cccggtgctg tacggcacgc tgcgggagaa tctgacctac tccgtcccgg
    14041 acgccgggcc ggaggagctg gaccgggtgg tcgagctggc acacctcacg gacctgatcg
    14101 cccgtctgcc tcgggggctg gacaccgacg ccggtgagca cggtatggcg ctctccggtg
    14161 gcgagcggca gcggatcgcg atcgcccgtg ccctgctggc ccggccgcgc ctgctcctgc
    14221 tggacgagcc gaccgcccat ctggacgcgg tcagcgaagc ggcgctgcgc aggtcgatgc
    14281 gggagaccgc gcgggagtgc acgctgctcg tgatcgcgca ccgcatgtcg accatccgcg
    14341 cagcagacct gatcgtcgtc ctcgacgccg gccgggtcgt ggccacgggc agccacgggg
    14401 atctcctcga cagcagtgag cactaccggt cgctcatccg cgctcagcag accggcgatc
    14461 tccgtgtgcc gcgaacggcc ggcctgaagg gcgcgaccgg gtgaccctcc gcacgcgtcg
    14521 cgtcccccgg cacgaggagc cggctcctca gaatcccagc ttgcgcaact gcctcggatc
    14581 ccgctgccag tccttcgcga ccttcacgtg caggtcgagg aagaccggcg tgcccagcag
    14641 ggcctcgatc tgtttgcggg acttgatgcc gacctccttc aggcgcttgc ccttggggcc
    14701 gatgatgatg cccttctggc tggggcgctc gatgtagacg aaggcgtgga tgtcgagcag
    14761 gggcttgtcg gcggggcggt cctcgcgggg gagcatctcc tcgacgacca cggcgatgga
    14821 gtgcgggagc tcgtcgcgga cgccctccag cgcggcctcc cggatcagtt ccgcgatcat
    14881 gacctgctcg ggctcgtcgg tcaggtcgcc ctcggggtag agcgccgggc cctccggcag
    14941 gagggggacg atcaggtcgg ccagcaggcc cacctgcttg tcgccgaccg ccgacaccgg
    15001 gacgatctcg gcccactcga agccgagttc cttgccgagc tggtcgatcg cgatgagctg
    15061 ctcggcgagt gtcttgctgt ccaccaggtc ggtcttggtg acgatggcga tcttcggcgt
    15121 cttcttgatg gacgccagtt ccttcgcgat gaagcggtcg ccggggccga gcttctcgtt
    15181 cgccggcagg cagaagccga tcacgtccac ctcggcccac gtggtgcgca cgatgtcgtt
    15241 cagccgctcg cccagcagcg tgcgcggctt gtgcagcccc ggggtgtcga ccaggatcag
    15301 ctgggcgtcc gagcggtgca cgatgccccg cacggtgtgc cgcgtggtct gcggctggtt
    15361 cgccgtgatc gccaccttct ggccgaccag agcattcgtg agggtggact tgcccgcgtt
    15421 gggacggccc acgaagcagg cgaagccagc ccggtggaca gcttcggccg gcttttcgga
    15481 tgactgggta cgaacgctca tggcgcccat tctccctgat ccacagagcc ctgccgcaca
    15541 ggcgcccgaa cctcccgccc cgtgccgccg gccgcagtcc ggcctggacc ttacggtgca
    15601 ctgcgggacg gcctacgatc acggcatcct gggccacggc gccccggtct ccccctccgt
    15661 cgtctccccc gcgcagaagg tcaccccagg catgaagctc atcaccgcga tcgtcaagcc
    15721 gtaccgcctc gacgagatca agaacgcctt gcaggagctc ggcgtgcacg gcctgaccgt
    15781 gagcgaggcc agcggctacg gccggcagcg cggccacacc gaggtgtacc gcggcgccga
    15841 gtaccaggtc gacctggtgc cgaagatccg catcgaggtc gtcgtcgacg acgcggacgc
    15901 cgaggccgtc atcgacgcgg tcgtgaaggc cgcgcacacc ggcaagatcg gcgacggcaa
    15961 ggtgtgggcg ctgccggtgg acacggtcgt gcgggtgcgg acgggcgagc gcgggccgga
    16021 cgcgctgtag gtcgcgcccg gcccgccggg atcagtcgaa gacgaacggg cccggcgact
    16081 ggggcccggt cgccgtgcag gtgatggtga tgccgaagac ggtcatcttc agcgagccgc
    16141 cgaaggcctc caggctgtcg ccggaggcca cggtgccgct gagggggccg acctcgacgg
    16201 gggcgccggc ggccatcgcc ggattctgag tgccggtgaa gtcgacggtg ccgccgccgg
    16261 ccttcaccag actgagcgtg gacgcgatcg agtcctcgcc gagggcgatc ggcgcggtga
    16321 tcgcggacga cttgacggtg agggtggcgg cggtgccgtc ctgcgtggcc gtgagcgtgg
    16381 cctcgccact gccgaaggtg ccgcagtcgg cgctgatcgt cgccgtctgg ggggtgacgg
    16441 cgagtgcggc gggggcgaag gcgagcccgg tgaccgcgag ggccccggcc gccagggccg
    16501 cgcctgctcc tgtgcgcttg catctcatgg gattccggct ccgtttccgt gtggggggac
    16561 gctcggcaga tgagtgcggg cacgtcacgc gagcgccgaa cctgacggtc cgtcggaatg
    16621 tacggatccc attgatgcgc gtggggcaga cggcggcaag gttgaattcg cgcctaatta
    16681 ccgccggtta cagcggactt cagccggcgg tcacggtcgt ccgcaccgtc ccgtcgggcc
    16741 cggccaccaa caccggcgtc tgcgcgccac cgagatcccg caccgccgcc cggtcctcgt
    16801 cggacgcggt ctccgcctcc gtcaccacgg ccgcggcctc cagggacttc gcgcccgagg
    16861 ccaccgccat cgccacggct gtctgcaggg cagtgagctt cagggagtcc agggccacgg
    16921 ttcccgcgac atacgtacgt ccggtctcgt cccgcacggc cgccccctcg ggcacgccgt
    16981 tgcgggcccg tgcggaacgg gccagggtga cgatcttgcg gtcctcgggg tcgagcgcgc
    17041 tgctgtcggt catgatccga gcatacggaa gcgtcagggc cggtcgaggc ggaggcggtc
    17101 agctcgcggc aggcccgcga cgacgaggtc gtaggagtcc tcgacgagct cacggaccaa
    17161 ccggtccggg agtcccccgt cgcacgtgac cgtgttccag tgccgcttgt tcatgtgcca
    17221 gcccgggacg atcaggccct cgtgctcgtg gcgcagccgg atcgcgtcgt ccgggtcgca
    17281 cttgaggttg accttcaggg ggcgcgcgtc gaggtgcgac agggcgaaca gcttgccctg
    17341 gaccttgaag accgagatct ccgggctgaa cgggaagtcc tcgacggccg cgttgaagga
    17401 caggcagaac gcgcgcagtt cctgcggggt cattccggct tctcctcctc cacgggatcc
    17461 gccgggtcca ccggctccgc cagcaccgtg acgatcttgt tccggcggcc cgccgcggcc
    17521 tccgcggtca ggcgcagttc ccggccgtcg gggagttcca cgacggagga cgcgccggcg
    17581 atggggaccc ggcccagcgc cttcgcgagc agaccgccga ccgtctcgac gtcctcgtcg
    17641 tcgaacgcct ccaggccgta cagctcgccc aggtctccga tgtccaggcg ggcggtgacc
    17701 cggtagcggt ccttgccgag gtcctccacc ggcggcagtt cgcggtcgta ctcgtcggtg
    17761 atctcgccga cgatctcctc caggatgtcc tcgatggtga cgatgccggc ggtgccgccg
    17821 tactcgtcga cggcgacggc gacgtggttg cgctccttct gcatctcgcg cagcaggtcg
    17881 cccgcgttct tggtgtcggg cacgaagaac gccgggcgca tcgccgtgga cacctgctcg
    17941 gactcggcgt cgcggctgat gtgcgtcttg cggaccaggt ccttcaggta cacgatcccg
    18001 acgatgtcgt cctcgctctc gccggtcacc gggatccggg agaaaccgga gcgcagggcg
    18061 agggtgaggg cctggcggat ggtcttgtag cgctcgatga ccaccaggtc cgtgcgcggg
    18121 accatgacct cgcggacgag ggtgtcgccc agctcgaaga ccgagtgcac catgcggcgc
    18181 tcgtcgtcct cgatgagcga ctccttctcg gccaggtcga ccagcgcgcg cagctccgcc
    18241 tcggaggcga agggaccgcg ccggaagccc ttgccggggg tgagcgcgtt gccgatgagg
    18301 atcagcagcg acgggatcgg gcccatgacc cgggccagcg gcaccaggac gtacgccgag
    18361 accgtcgccg tgttcagcgg gtgctggcgg ccgatggtgc gcggggagac gccgacggcg
    18421 acgtacgaca cgaggaccat gaccgcgatg gcgatcagga gggcctcggt cgtgttgtcg
    18481 aactccatca ggcagccgta cgtgatcagc gcggcggcgg ccatctcgca ggcgacgcgc
    18541 accagcagcg ccacgttcag gtagcgggtc gggtcggcgg cgacctggga cagcttggcg
    18601 ctgccccggc ggccggagcg cacggcctcc tcggcgcgga agctggagac ccgcgcgagg
    18661 cccgcctccg cgcaggcgaa gagccaggcc acgacgacca gggcgaccgc gcccagggcg
    18721 agttgcggac tcatcggcgg cgctacgaga ccgtcggcgc cggggacggg ccggtcaggc
    18781 cccgctccgc gcgccagccg tccacgatgg ccgcctggag gccgaacatc tcggccttct
    18841 cgtccggttc ctcgtggtcg tagcccagca ggtgcagcac tccgtggacg gtgagcagtt
    18901 ggagctcctc gtccatggag tgctgcgtgt cggcttcctt gccctgcttc tgagcgacct
    18961 cggggcacag cacgatgtcg ccgagcagcc cctgcggcgg ctcgtcgtcg tccttggagg
    19021 gcgggcgcag ctcgtccatc gggaaggaca tgacatccgt cgggcccggc aggtccatcc
    19081 actggatgtg cagctgctcc atggcggcgg cgtccacgac gatcaccgag agctcggaga
    19141 gcgggtggat gcgcatccgc gcgagcgcgt aacgggcgat gtcgaggatc gcctgctcgt
    19201 cgacctcggt accggactcg ttgttgacgt cgatcgacat ggtgctgtgt gtgctacttc
    19261 cccttgtgcc cggacttgcc gcggcccttg tgcgcgccgt tctgggtgcc gtgcttggtg
    19321 tcgtactgct cgtacgcgtc gacgatacgg cccaccagct tgtgccggac gacgtcgtgg
    19381 gacgacaggc gggagaagtg gacgtcctcg acgccgtcca ggatgtcctg gacctgccgc
    19441 agaccgctct tcgtcccctc cgggaggtcg acctgcgtca cgtcgcccgt gatcacgatc
    19501 ttcgagtcga agccgaggcg ggtgaggaac atcttcatct gctcggggct cgtgttctgg
    19561 gcctcgtcca ggatgatgaa ggcgtcgttg agcgtgcggc cgcgcatgta ggcgagcggc
    19621 gcgacctcga tcgtgcccgc cgccatcagc cgcgggatcg agtccgggtc gagcatgtcg
    19681 tgcagcgcgt cgtaaagcgg gcgcaggtac gggtcgatct tctcgtagag cgtgcccggg
    19741 aggaatccga gccgctctcc ggcctcgacc gccgggcggg tcaggatgat gcggttgacc
    19801 tgcttggact ggagggcctg gacggccttg gccatggcca ggtacgtctt gccggtaccc
    19861 gccgggccga tgccgaagac gatcgtgtgc ttgtcgatcg cgtccacgta gcgcttctgg
    19921 ttgagcgtct tggggcggat cgtgcggcct cgcgaggaca ggatgttctg cgtgagcacc
    19981 tgggcagggg tctcctggcc gtcgctctcc ccgttctcgc tcgccttgag catggcgatc
    20041 gagcgttcca ctgcgtcctc cgtcatcggc tgtccggtgc ggagcaccag catcatctcg
    20101 tcgaacacgc gggcgatgag ggcgacgtcc acagggtcgc cgaccgcgct gatctcattg
    20161 ccccggacgt ggatgtcggc cgccgggaag gccttctcga tcacgcgcag gagggcgtcg
    20221 ccggacccca gcaccgtcac catcgggtgc tgggcgggga cggtgaactg tgctctcgcc
    20281 tgctcctgcg cgggggtgtg agctgtgggt gtctgagtca tgggccggcg ctgaaggcct
    20341 gcggttcctc ctcttcacgg ccgcgtagct gagggcggcc tcgcgattcc cagggtacga
    20401 cggtggactg acaacgccgt aggggttttg ggggtggggt ttgcaaccgg ggacgacagc
    20461 ggctcttgac cgggcgattc ccctgggcgg ccagggcgtc acgccgagcg ccgaaagccg
    20521 atcgtaggta cggcgcgccg caacggccag ggcctgacca gctcctcgga caccaggtcg
    20581 gccaggaacc cgtacctctc caacgccacc gccgactgcc cctccaccga ctgcacccgc
    20641 cgccaccacg ccgcgatctc cgaccacccc ggcgccgaca acgacccccc gaactcctgc
    20701 accgacagcg ccgcggtcag cccggcgaag gccagccggt ccgccagcgg ccagtccgcc
    20761 agcgtccccg tcacgaaccc ggcgacgaac acgtcccccg cccccgtcgg atcgagcgcc
    20821 tcgacctcga tcgccggcac ctccgccgtc tcccccgtac gccggtccac cgcatacgcc
    20881 ccgtccgccc cgagcgtgac caccgcgagc ggcacgtgct cggtcagcgc gtgcgccgcc
    20941 gccctggggc agtccgcgcc cgtgtaccgc atggcctcct ccgcgttcgg caggaacgcc
    21001 tcgcagtgcc gcaggtcggg cagcgccgcc aggtcccacg cgccggtgtc gtcccagccg
    21061 acgtcgccga agacccgcgt gcccttgctc gcggcctggg cgatccaggg cgcgctcacg
    21121 ccgggggcga gggaggcgac ggcggcacgc gcgcggggcg ggcactcggg ggcgggctcc
    21181 tccgggggcg gctcgtggcc gtgcgagacc atggtgcgct ccccctcgta ggccatggag
    21241 accgtcaccg gggagtgcca gccgggcacc gtgcgcgacg gggagaggtc gatgccctca
    21301 ccgtgctcca gggcgtccca gcagtagtcg ccgtagtggt cgtcgccgaa ggccgccgcg
    21361 agggacgtac gcaggccgag gcgggccagg gcggtggcca tgttggcgac gccgccgggg
    21421 ctcgacccca tcccgcgcgc ccaggactcg gtcccgcgca ccggggcgga gtcgagcccg
    21481 gtgaagatga tgtcgaggaa gacggtgccg gtgagataga cgtcccaggg cgggtcgtcc
    21541 ggcgcgcgca gcggggcgag gggatcgacc tgggtctggc ggtgcgatcc ctttccggcc
    21601 gggccctttc ctgccggggc ggtggacgcg atcacgatgc gctccctgac gtggtgcgga
    21661 tcaggccagt ctgcaccaca tcactgacaa cgtgacgccg atcacgccag acccactcgt
    21721 tccgtcagct cacgcccgcc cccgcgcgcc ccttggccgg ccggagaacc gggcctacca
    21781 gcggggcacc gagggcgtca cccactccgg gtcggcgacc cgcatggccg ccgcgtcgtc
    21841 gcggtcccgc agcgccccgt cgtcgtccag ccaccgccgg tgcagcacgg ccagccgctc
    21901 acggtcgagc tccacgccga gcccgggcgc gtcggacacg ggcaccttgc cgccctcgaa
    21961 ggcgagccgc tcggtgagca cgtcctccga ctgccagggg tagtgggagt cgcaggcgtg
    22021 gtggaggttc gggacggtgg ccgccacgtg ggtcatcgcg gcgagcgaga tgcccaggtg
    22081 ggtgttggag tgcatcgaca ctccgacgcc gaaggtgcgg cagacggcgg cgagctgctg
    22141 ggtgttgcgc agtccgcccc agtagtggtg gtcggagagc accacctgga cagcgccgcc
    22201 ggcgcccgtg gtgaacgcct ccttgatctc ggcgaaggtc gtcacgcaca tgttggtggc
    22261 gagcggcacc ccggtccgct cggcgacctc ggccatggcg gggatgccga gggtcgggtc
    22321 ctccaggtac tccaggacgt ccccgagctc ccgcgccacc ttcagcgagg tctccaggga
    22381 ccaggcgccg ttgggatcga gccgcagcgg gtgcccgggg aacgcctcgg cgagcgcccg
    22441 tacggccgcg atctcctcgt cgggcgggaa gacgccgccc ttgagcttga aggaggtgaa
    22501 gccgtaccgc tcggtgaacc ggcgggcctg ttccaccact ccggccgggt cgacggctgc
    22561 cccccagtcg tccttctcgc aggcgacgcc ctccgggtgg ccggcccact tgtagaacag
    22621 gtaggcgctg tactcgacgg cgtcgcgcac cttgccgccg agcagcgcgt gcacgggcag
    22681 tccgagggtc ttgccgaggg
//
