LOCUS       NZ_CP023694            10399 bp    DNA     linear   CON 13-JUL-2024
DEFINITION  Streptomyces coeruleorubidus strain ATCC 13740 chromosome, complete
            genome.
ACCESSION   NZ_CP023694
VERSION     NZ_CP023694.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces coeruleorubidus
  ORGANISM  Streptomyces coeruleorubidus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 9335698)
  AUTHORS   Lee,N. and Cho,B.-K.
  TITLE     Direct Submission
  JOURNAL   Submitted (27-SEP-2017) Biological Science, KAIST, 291 Daehak-ro,
            Daejeon 34141, South Korea
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 2.3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 50X
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_008705135.1-RS_2024_04_23
            Annotation Date                   :: 04/23/2024 03:16:00
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,499
            CDSs (total)                      :: 8,405
            Genes (coding)                    :: 8,179
            CDSs (with protein)               :: 8,179
            Genes (RNA)                       :: 94
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 73
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 229
            CDSs (without protein)            :: 226
            Pseudo Genes (ambiguous residues) :: 0 of 229
            Pseudo Genes (frameshifted)       :: 96 of 229
            Pseudo Genes (incomplete)         :: 175 of 229
            Pseudo Genes (internal stop)      :: 12 of 229
            Pseudo Genes (multiple problems)  :: 53 of 229
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 14:54:21
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2257183
            Orig. end                         :: 2267582
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP023694.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria available from Korean Collection for Type Cultures.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10399
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ectoine"
                     /region_number="6"
                     /rules="ectoine_synt"
                     /tool="antismash"
     cand_cluster    1..10399
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="ectoine_synt"
                     /kind="single"
                     /product="ectoine"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10399
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5399](+)"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5399
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
     gene            877..1986
                     /db_xref="GeneID:91416526"
                     /locus_tag="CP976_RS10555"
                     /old_locus_tag="CP976_10580"
     CDS             877..1986
                     /NRPS_PKS="Domain: Aminotran_5 (73-339). E-value: 9.2e-30.
                     Score: 95.7. Matches aSDomain:
                     nrpspksdomains_CP976_RS10555_Aminotran_5.1"
                     /codon_start=1
                     /db_xref="GeneID:91416526"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139: aminotransferase class V"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019329315.1"
                     /locus_tag="CP976_RS10555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_10580"
                     /product="aminotransferase class V-fold PLP-dependent
                     enzyme"
                     /protein_id="WP_150480108.1"
                     /sec_met_domain="Aminotran_5 (E-value: 2.8e-23, bitscore:
                     81.4, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTHPFLDLAPLGADRFAAIEDRVARLLSTEQDVVIMQGEALLPLE
                     GAIRAAAGPGTTALNVITGPYGQTFGDWLRDCGATVVDLAVPFHTAVTAEQIRQAFAEH
                     PEIDFVSLVHAEAATGNTNPVAEIGEVVRAHGALFYLDAVASIGAEPVLPDAWGVDLCV
                     IGAQKAMGGPAGVSAVSVSERAWARMAANPRAPRRSYLSLLDWKERWIGGGRKALLHAP
                     AQLEMLALEACVERIEAVGLDAVMARHASAAAATRAGAVGLGGGLEPYVYEARDAAPVA
                     TTLRAPSGVVASELVARALEADPAVPVAAGGGALAKEMIRVNHYGPDATPGAVRASLAA
                     LGAALSEAGLPVDVEGALRAAGEAWRETF"
     aSDomain        1096..1893
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CP976_RS10555_Aminotran_5.1"
                     /evalue="9.20E-30"
                     /label="CP976_RS10555_Aminotran_5.1"
                     /locus_tag="CP976_RS10555"
                     /protein_end="339"
                     /protein_start="73"
                     /score="95.7"
                     /tool="antismash"
                     /translation="LRDCGATVVDLAVPFHTAVTAEQIRQAFAEHPEIDFVSLVHAEAA
                     TGNTNPVAEIGEVVRAHGALFYLDAVASIGAEPVLPDAWGVDLCVIGAQKAMGGPAGVS
                     AVSVSERAWARMAANPRAPRRSYLSLLDWKERWIGGGRKALLHAPAQLEMLALEACVER
                     IEAVGLDAVMARHASAAAATRAGAVGLGGGLEPYVYEARDAAPVATTLRAPSGVVASEL
                     VARALEADPAVPVAAGGGALAKEMIRVNHYGPDATPGAVRASLA"
     gene            2262..2789
                     /db_xref="GeneID:91416527"
                     /locus_tag="CP976_RS10560"
                     /old_locus_tag="CP976_10585"
     CDS             2262..2789
                     /codon_start=1
                     /db_xref="GeneID:91416527"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010037835.1"
                     /locus_tag="CP976_RS10560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_10585"
                     /product="DinB family protein"
                     /protein_id="WP_150480109.1"
                     /transl_table=11
                     /translation="MTTNTPITLPDGRPVPHLTGDERAMLESWLDFHRATLALKCAGLD
                     DAQVRTAAAEPSTLTLLGLVQHLAEVERNWFQRVAAGLDVPPVYEDGTGYTLDPSRGID
                     EALGIWRREIERGRELCAGLPLDHIGRVAEGPVPGMEVSMRWVLIHMIEEYARHNGHAD
                     LLRERIDGVTGA"
     misc_feature    2842..2855
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.75"
                     /tool="antismash"
     misc_feature    complement(2957..2972)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.52"
                     /tool="antismash"
     misc_feature    3091..3103
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 17.04"
                     /tool="antismash"
     gene            3128..3634
                     /db_xref="GeneID:91416528"
                     /gene="ectA"
                     /locus_tag="CP976_RS10565"
                     /old_locus_tag="CP976_10590"
     CDS             3128..3634
                     /EC_number="2.3.1.178"
                     /GO_function="GO:0033816 - diaminobutyrate
                     acetyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0019491 - ectoine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91416528"
                     /gene="ectA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003989362.1"
                     /locus_tag="CP976_RS10565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_10590"
                     /product="diaminobutyrate acetyltransferase"
                     /protein_id="WP_059422330.1"
                     /transl_table=11
                     /translation="MTAVQADPQIDRPTVADGAALWRMAKDSKVLDLNSSYSYLLWCRD
                     FAATSAVARDEHGEPMGFITGYVRPDSPHTLLVWQVAVDEAHRGRGLAATLLDGLVART
                     VAERGVTTVETTITPGNTASERLFTSFAERHGARLEREVLFDTAVFPDGPHDPEVLYRI
                     GPLSH"
     gene            3687..4958
                     /db_xref="GeneID:91416529"
                     /gene="ectB"
                     /locus_tag="CP976_RS10570"
                     /old_locus_tag="CP976_10595"
     CDS             3687..4958
                     /EC_number="2.6.1.76"
                     /GO_function="GO:0045303 - diaminobutyrate-2-oxoglutarate
                     transaminase activity [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_3 (29-366). E-value: 7.9e-74.
                     Score: 240.6. Matches aSDomain:
                     nrpspksdomains_CP976_RS10570_Aminotran_3.1"
                     /codon_start=1
                     /db_xref="GeneID:91416529"
                     /gene="ectB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007448159.1"
                     /locus_tag="CP976_RS10570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_10595"
                     /product="diaminobutyrate--2-oxoglutarate transaminase"
                     /protein_id="WP_059422331.1"
                     /sec_met_domain="Aminotran_3 (E-value: 2.2e-78, bitscore:
                     262.6, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTITQPDLSVFETVESEVRSYCRGWPTVFDRAVGSRMYDEDGHEY
                     LDFFAGAGSLNYGHNNPVLKRALIDYLERDGVTHGLDMSTTAKRTFLEAFQNLLLRPRD
                     LPYKVMFPGPTGTNAVEAALKLARKVKGRESIVSFTNAFHGMSLGSLAVTGNAFKRAGA
                     GIPLVHGTPMPFDNYFDGTVEDFLWFERLLEDQGSGLNKPAAVIVETVQGEGGINVARP
                     EWLRALSELCERQDMLLIVDDIQMGCGRTGAFFSFEEAGITPDIVTVSKSISGYGLPMS
                     LCLFKPELDVWEPGEHNGTFRGNNPAFVTATAALEAYWADGSAMEKQTRKRGEQVEQAL
                     ISITEENLADVKEYRGRGLVWGMEFHDKDRAGKIAKRAFELGLLIETSGPESEVVKLLP
                     ALTITPEELDEGLSTLARAVRETA"
     aSDomain        3774..4784
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CP976_RS10570_Aminotran_3.1"
                     /evalue="7.90E-74"
                     /label="CP976_RS10570_Aminotran_3.1"
                     /locus_tag="CP976_RS10570"
                     /protein_end="366"
                     /protein_start="29"
                     /score="240.6"
                     /tool="antismash"
                     /translation="DRAVGSRMYDEDGHEYLDFFAGAGSLNYGHNNPVLKRALIDYLER
                     DGVTHGLDMSTTAKRTFLEAFQNLLLRPRDLPYKVMFPGPTGTNAVEAALKLARKVKGR
                     ESIVSFTNAFHGMSLGSLAVTGNAFKRAGAGIPLVHGTPMPFDNYFDGTVEDFLWFERL
                     LEDQGSGLNKPAAVIVETVQGEGGINVARPEWLRALSELCERQDMLLIVDDIQMGCGRT
                     GAFFSFEEAGITPDIVTVSKSISGYGLPMSLCLFKPELDVWEPGEHNGTFRGNNPAFVT
                     ATAALEAYWADGSAMEKQTRKRGEQVEQALISITEENLADVKEYRGRGLVWGMEFH"
     gene            5001..5399
                     /db_xref="GeneID:91416530"
                     /locus_tag="CP976_RS10575"
                     /old_locus_tag="CP976_10600"
     CDS             5001..5399
                     /codon_start=1
                     /db_xref="GeneID:91416530"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ectoine: ectoine_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009337952.1"
                     /locus_tag="CP976_RS10575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_10600"
                     /product="ectoine synthase"
                     /protein_id="WP_059422332.1"
                     /sec_met_domain="ectoine_synt (E-value: 1.7e-54, bitscore:
                     181.9, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIVRSFKEIEGTDRHVKSASGTWESKRIVLAKEKVGFSLHETILY
                     AGTETSMWYANHIEAVVCVEGEAELTDRETGKSYTITPGTMYLLDGHEKHTLRIKKDFR
                     CLCVFNPPVTGREDHDENGVYPLLTEEV"
     gene            5415..6314
                     /db_xref="GeneID:91416531"
                     /gene="thpD"
                     /locus_tag="CP976_RS10580"
                     /old_locus_tag="CP976_10605"
     CDS             5415..6314
                     /EC_number="1.14.11.55"
                     /codon_start=1
                     /db_xref="GeneID:91416531"
                     /gene="thpD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PhyH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003976953.1"
                     /locus_tag="CP976_RS10580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_10605"
                     /product="ectoine hydroxylase"
                     /protein_id="WP_190146946.1"
                     /sec_met_domain="PhyH (E-value: 9.7e-39, bitscore: 132.7,
                     seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDTTTGIPDLYPSRGATEVLTPRQDPVVWGAPDAPGPVAPADLL
                     SFERDGFLAIDELITDDEVAVYRNELNRLVNDPDIRADERSIVEPLSKEIRSVFEVHKI
                     SEVFAKLVRDERVVGRARQILGSDVYVHQSRINVKPGFGASGFYWHSDFETWHAEDGLP
                     RMRTVSVSIALTENYDTNGGLMIMPGSHKTFLGCAGATPKDNYKKSLQMQDAGTPSDDA
                     LTLLASQHGIKLFTGKAGSATWFDCNCMHGSGDNITPFPRSNVFIVFNSVENTAVEPFA
                     APVRRPEFIGARDFTPVR"
     gene            complement(6525..7577)
                     /db_xref="GeneID:91416532"
                     /locus_tag="CP976_RS10585"
                     /old_locus_tag="CP976_10610"
     CDS             complement(6525..7577)
                     /NRPS_PKS="Domain: Aminotran_5 (17-344). E-value: 1.5e-23.
                     Score: 75.2. Matches aSDomain:
                     nrpspksdomains_CP976_RS10585_Aminotran_5.1"
                     /codon_start=1
                     /db_xref="GeneID:91416532"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139: aminotransferase class V"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010037842.1"
                     /locus_tag="CP976_RS10585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_10610"
                     /product="aminotransferase class V-fold PLP-dependent
                     enzyme"
                     /protein_id="WP_190146936.1"
                     /sec_met_domain="Aminotran_5 (E-value: 1.1e-17, bitscore:
                     63.0, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="METFENLVRAEFAPKHTYLNTASNGLLPARTVTAVQQAVRMRAEG
                     TPLGPLYEDVEAARACFARLAGVPAERVATGASVAEYGGLIAASLPAGAEVLTAEADFA
                     SLVNPFHARGDLKVRAVPLERLAESVRPGTALVAVSTAQSADGRLADLPAVREAARAHG
                     ARTYVDASQSAGWLPMEADADDFLAAVGFKWLLGPHGAAFFVTPQDFGGLTPLLAGWVA
                     GEVPWESCYGPVEELAHSARRFDISPSLFTYAGLRASLELLEEIGVDVVHAHDVALADR
                     FRVGLAELGHAPVPAPGSAIVSVPGLGHRQQELSRAGIQVSDRAGNLRAAFHLYNTPAD
                     VDRLLEVLAA"
     aSDomain        complement(6546..7526)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CP976_RS10585_Aminotran_5.1"
                     /evalue="1.50E-23"
                     /label="CP976_RS10585_Aminotran_5.1"
                     /locus_tag="CP976_RS10585"
                     /protein_end="344"
                     /protein_start="17"
                     /score="75.2"
                     /tool="antismash"
                     /translation="YLNTASNGLLPARTVTAVQQAVRMRAEGTPLGPLYEDVEAARACF
                     ARLAGVPAERVATGASVAEYGGLIAASLPAGAEVLTAEADFASLVNPFHARGDLKVRAV
                     PLERLAESVRPGTALVAVSTAQSADGRLADLPAVREAARAHGARTYVDASQSAGWLPME
                     ADADDFLAAVGFKWLLGPHGAAFFVTPQDFGGLTPLLAGWVAGEVPWESCYGPVEELAH
                     SARRFDISPSLFTYAGLRASLELLEEIGVDVVHAHDVALADRFRVGLAELGHAPVPAPG
                     SAIVSVPGLGHRQQELSRAGIQVSDRAGNLRAAFHLYNTPADVDRL"
     gene            complement(7673..8386)
                     /db_xref="GeneID:91416533"
                     /locus_tag="CP976_RS10590"
                     /old_locus_tag="CP976_10615"
     CDS             complement(7673..8386)
                     /codon_start=1
                     /db_xref="GeneID:91416533"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003976951.1"
                     /locus_tag="CP976_RS10590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_10615"
                     /product="DsbA family oxidoreductase"
                     /protein_id="WP_150485299.1"
                     /transl_table=11
                     /translation="MRVEIWSDIACPWCYVGKARFEKALRDFPHRDDVEVVHRSFELDP
                     GRAKDDIQPVITMLTGKYGMSRAQAEAGEDNLGAQAAAEGLDYRTRGRDHGSTFDMHRL
                     LHFAKEQGRQEQLLDLLYRANFAEERSVFNDDERLVELAVSAGLDAEAVRAVLADAGAY
                     ADDVRADEREAAQLGASGVPFFVLDRTYGVSGAQPAEVFAQALTQAYGERSPLKLVDSG
                     DADACGPDGCAVPQH"
     gene            complement(8463..8957)
                     /db_xref="GeneID:91416534"
                     /locus_tag="CP976_RS10595"
                     /old_locus_tag="CP976_10620"
     CDS             complement(8463..8957)
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:91416534"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003989368.1"
                     /locus_tag="CP976_RS10595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_10620"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_190146937.1"
                     /transl_table=11
                     /translation="MIKNRVTPDRVIRTALPAEVADVVALHARARATYYPDGLPQDGTD
                     WLAIWESALARPEGRVLCVVEAGRIVGLASFRTPEGAPADTVKLFQFHVDPDHWRGGIG
                     TALHAACVEEWQADGRRTAVLDVHVDNLRAQGFYRRQGWVPEPAEPGDHHLTMRLSLAA
                     E"
     gene            complement(9004..9612)
                     /db_xref="GeneID:91416535"
                     /locus_tag="CP976_RS10600"
                     /old_locus_tag="CP976_10625"
     CDS             complement(9004..9612)
                     /codon_start=1
                     /db_xref="GeneID:91416535"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016436202.1"
                     /locus_tag="CP976_RS10600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP976_10625"
                     /product="DUF1349 domain-containing protein"
                     /protein_id="WP_150480112.1"
                     /transl_table=11
                     /translation="MDLEIPELPFPLRSYGPEAHWSYEDGVLTGWAGARQDRFVPPTGE
                     GLDPASDAPRLLGAPEGDFQLIARVTVGFGAAFDAGVLYVNVGERAWAKLCLEYSPDVP
                     TVCTVVTRGHSDDANSFAVDGSSVWLRVSRTGRAFAFHASRDGERWTFVRLFTLGDEKE
                     TGAALIGFMTQSPMGEGCVVTYDRVEFRPHWPNDLRDGS"
     misc_feature    complement(9582..9595)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.06"
                     /tool="antismash"
ORIGIN
        1 acgacctcga aggcgtcggc gttggccttg tccttcagcc agccctggac gaccgggtag
       61 tcgatgacga cggcctggac ctggccggtg cgcagaccgt tgaggacggc gtcggaggac
      121 tcgaaggaga ccgggtcgag gcccttgctc ttggcgtagt cctcaccggt cgtctgtgcc
      181 tgggcgccga gcttcttgcc cttgaggccg gcgaaggagg agatgccgct cttcttgtcg
      241 accagcacgg cctgggtggc gttgaagtac gggtcggaga agtcgacgtt cttcttgcgc
      301 tcctcggtga tggtcatgcc ggccgcggcg aggtcgcact cgccggagtt gaggaacgcg
      361 ccggtcttga agttctcgaa gggcgtgtcg aggatgtcct gctgcacgcc caggtccttg
      421 gcgaccaggt cgatcagcgc gacgtcgaag ccctgcacct tgccgtcgat ctccgactgg
      481 aacggcggat acggcaggtg ggtgcaggtg gtgagcttgc ccgccttgac gacttcgacg
      541 ccgcccgcgg ccgtcttcga gccgctgccg ccgtcgtcgg tggaggtgca gccggccacg
      601 agcagcagcc cggccgtcgc ggtggtggcg gccaggatgc gggcccggtg cccggggtgc
      661 gtgttcacgg cgagcctcct gtgagtgaac tgtgggttcc gatcataagg agaagtttga
      721 gtggctcaaa acaatccgat ggccgcgagg gcgtcgggcc tgcgaagtca ccggtcgtag
      781 ggggctgggg cgcggtcgta gcgggctggg gcgcggcggt tacgctcgtt cccgttgttc
      841 ccgcgagtag tccccgcacg tgaagagagt gccaccgtga cgcatccgtt tctggacctg
      901 gccccgctcg gggcggaccg tttcgccgcg atcgaggacc gtgtggcgcg gctgctgagc
      961 accgagcagg acgtcgtgat catgcagggt gaggcgctgc tgccgctgga gggcgcgatc
     1021 cgcgccgcgg ccggtccggg caccacggcc ctgaacgtca tcacggggcc gtacgggcag
     1081 accttcggcg actggctgcg cgactgcggg gcgacggtgg tcgacctggc ggtgcccttc
     1141 cacacggcgg tcacggccga gcagatccgg caggccttcg ccgagcaccc ggagatcgac
     1201 ttcgtgtccc tggtgcacgc ggaggcggcg accgggaaca ccaatccggt cgcggagatc
     1261 ggcgaggtgg tgcgcgcgca cggggccctg ttctacctgg acgcggtggc gtcgatcggt
     1321 gccgagccgg tgctgccgga cgcgtggggc gtggatctgt gcgtgatcgg ggcgcagaag
     1381 gcgatgggcg gcccggccgg tgtgtcggcc gtgtcggtga gcgagcgggc ctgggcccgg
     1441 atggcggcga acccgcgggc gccgcgccgg tcgtatctgt cgctgctcga ctggaaggaa
     1501 cggtggatcg gcggcggccg caaggcgctg ctgcacgctc cggcgcagct ggagatgctg
     1561 gcgctggagg cgtgtgtgga gcggatcgag gcggtggggc tcgacgcggt gatggcccgg
     1621 cacgcgtcgg ccgcggcggc cacccgggcc ggggcggtcg ggctcggtgg cgggctggag
     1681 ccgtatgtgt acgaggcgcg ggacgcggcg cccgtcgcca cgacgctccg ggcgccgtcc
     1741 ggggtggtgg cgtcggagct ggtggccagg gcgctggagg cggatccggc ggtgccggtc
     1801 gccgccggcg ggggtgcgtt ggccaaggag atgatccggg tcaaccacta cgggcccgat
     1861 gcgacgccgg gggccgtgcg ggcgagtctg gcggcgctgg gcgccgcgct ctcggaggcg
     1921 gggctgccgg tggacgtgga gggggcgctg cgggcggccg gggaggcgtg gcgggaaacc
     1981 ttctaggggg tgtccgcaaa gtcccgtcgt ccgcccggag ggcgggcccg gcggcgtccg
     2041 gtgcgtgctc tgggggtccc cccggccgaa ggctggggga gtgccgggcg gacgcccgcg
     2101 tactggttgt acgcgggtgt tcgaccggtg cggcgagtgg gggcacctcc cacgccctta
     2161 aggcagtggg ggagcgtgcc gggcgtcgca gggcaggcgg gactttgcgg acacccccta
     2221 ggggcccgcc cgttgtcggt ggcccgtgcc aagctccccc catgaccacc aacaccccca
     2281 tcacccttcc cgacggccgt cccgtcccgc atctgaccgg tgacgaacgg gccatgctcg
     2341 agagctggct ggacttccac cgggccacgc tggcgctgaa gtgcgccggg ctggacgacg
     2401 cgcaggtgcg gaccgcggcg gccgagccgt ccacgctgac gctgctcggg ctggtgcagc
     2461 acctcgccga ggtcgagcgg aactggttcc agcgggtggc cgccgggctc gacgtgccgc
     2521 cggtgtacga ggacggcacc ggctacacgc tggacccgtc gcgcggtatc gacgaggcgc
     2581 tcgggatctg gcggcgggag atcgagcggg ggcgggagct gtgtgcgggg ctgccgctgg
     2641 accacatcgg gcgggtcgcc gaggggccgg tgcccgggat ggaggtcagc atgcgctggg
     2701 tgctgatcca catgatcgag gagtacgccc ggcacaacgg tcacgccgat ctcctgcggg
     2761 aacgtatcga cggagtgacc ggggcttgaa ttaaacgtgt ttccgggacg acccacatgt
     2821 aagctggcac acaattagga attctttcaa gaacagcttc ccgtattctt ctgcccgctt
     2881 ttcctgatcc taaacccaaa gattttgagg acacctggag aaggaattcg ggcagatctc
     2941 gtggtgatta cacggctgtg acgcgttaca caccgtgact gctttgcccg gtattacccg
     3001 gacaatatcg ggcatacctc tgcccttttg cgcgaaccct cgcgcccgcg tgataacaca
     3061 ggcctggctc atacgtaacc cctatcggcg atgcaatttt gaatttcgct gggtaagttc
     3121 aattcgcatg actgccgtac aagcagatcc gcaaatcgac cgcccaacgg tggctgacgg
     3181 agccgcgctc tggcggatgg cgaaggactc gaaggttctc gacctgaact cgtcctacag
     3241 ctatctgctg tggtgccgcg acttcgcggc cacgtcggcc gtggcgcgtg acgagcacgg
     3301 cgagccgatg ggtttcatca ccgggtacgt gcggccggac agcccgcaca ccctgctggt
     3361 ctggcaggtg gcggtggacg aggcacaccg cgggcgcggg ctggccgcca cgctgctcga
     3421 cggtctggtc gcccggaccg tcgccgagcg cggggtgacg acggtggaga ccaccatcac
     3481 cccgggcaac accgcctcgg agcgcctgtt cacgtcgttc gccgagcgtc acggcgcccg
     3541 gctggagcgc gaggtgctct tcgacacggc cgtgttcccc gacgggccgc acgaccccga
     3601 ggtcctgtac cgcatcggcc cgctgtccca ctgacttcct gccggactcc cgcagacttc
     3661 ccccacgtac cgaggagcga ttcgtcgtga ccatcaccca gcccgacctg agtgtcttcg
     3721 agaccgttga gtccgaggtg cgcagctact gccgcggctg gcccaccgtc ttcgaccgtg
     3781 cggtgggcag ccgtatgtac gacgaggacg gccatgagta cctcgacttc ttcgccggag
     3841 ccgggtcact gaactacggg cacaacaacc ccgtcctgaa acgcgccctg atcgactacc
     3901 tggagcggga cggcgtcacg cacgggctcg acatgtcgac caccgccaag cgcacgttcc
     3961 tggaggcctt ccagaacctg ctgctgcggc cgcgcgacct gccgtacaag gtcatgttcc
     4021 ccggcccgac cggcaccaac gccgtggagg ccgcgctgaa gctggcgcga aaggtgaagg
     4081 ggcgcgagtc catcgtgtcc ttcaccaacg ccttccacgg catgtcgctg ggctcgctgg
     4141 ccgtgaccgg caacgccttc aagcgggccg gtgccggtat cccgctggtg cacggcacgc
     4201 ccatgccgtt cgacaactac ttcgacggca cggtcgagga cttcctgtgg ttcgagcggc
     4261 tgctggagga ccagggctcc ggcctgaaca agccggccgc cgtgatcgtc gagaccgtgc
     4321 agggcgaggg cggcatcaac gtggcccggc ccgagtggct gcgcgccctg tccgagctgt
     4381 gcgagcggca ggacatgctg ctgatcgtcg acgacatcca gatgggctgc ggccgcaccg
     4441 gcgccttctt ctccttcgag gaggcgggca tcacgccgga catcgtcacc gtctcgaagt
     4501 cgatcagcgg ctacggcctg ccgatgtcgc tgtgcctgtt caagccggag ctcgacgtgt
     4561 gggagcccgg cgagcacaac ggcaccttcc gcggcaacaa ccccgccttc gtcacggcga
     4621 ccgcggccct ggaggcgtac tgggccgacg gctccgcgat ggagaagcag acccgcaagc
     4681 gcggtgagca ggtcgagcag gcgctgatct ccatcaccga ggagaacctg gccgacgtga
     4741 aggagtaccg gggccgcggc ctggtgtggg gcatggagtt ccacgacaag gaccgcgcgg
     4801 gcaagatcgc caagcgcgcc ttcgaactcg gcctgctcat cgagacgtcc gggccggaga
     4861 gcgaggtcgt gaaactgctc cccgccctga ccatcacgcc cgaggaactg gacgagggcc
     4921 tgtcgacact ggcccgcgcc gtccgcgaga ccgcctgacc gagcaaccgg caccacccat
     4981 ttaggaggca tcgcagcacc gtgattgtcc gttcgttcaa ggagatcgaa ggtaccgacc
     5041 ggcacgtgaa gtcggcgtcc ggcacgtggg agagcaaacg catcgtcctc gccaaggaga
     5101 aggtcggctt ctccctgcac gagacgatcc tgtacgcggg tacggagacg tcgatgtggt
     5161 atgcgaacca catcgaggcc gtcgtctgcg tggagggcga ggccgagctg accgaccgcg
     5221 agaccgggaa gtcgtacacc atcacgcccg ggaccatgta cctcctggac gggcacgaga
     5281 agcacacgct gcggatcaag aaggacttcc gctgcctctg cgtcttcaat ccgcccgtga
     5341 ccggacggga ggaccacgac gagaacggcg tttacccgct gctcaccgag gaggtgtgac
     5401 gtttcatgac cgccatcacc gacaccacca ccggtatccc cgacctctat cccagtcggg
     5461 gcgccaccga ggtgctcacc ccgcgccagg acccggtcgt ctggggcgcc cccgacgcgc
     5521 ccggtccggt cgcgccggcc gatctgctgt ccttcgagcg tgacggcttc ctcgccatcg
     5581 acgagctgat caccgacgac gaggtcgccg tctaccggaa cgagctcaac cggctggtga
     5641 acgacccgga catccgtgcc gacgagcggt cgatcgtcga gccgctgtcc aaggagatcc
     5701 gctcggtctt cgaggtgcac aagatcagcg aggtgttcgc caagctggtg cgggacgagc
     5761 gggtcgtcgg ccgggcgcgg cagatcctcg gctcggacgt ctacgtccac cagtcgcgga
     5821 tcaacgtcaa gccggggttc ggggccagtg gcttctactg gcactcggac ttcgagacgt
     5881 ggcacgccga ggacggtctg ccgcggatgc gcacggtgtc ggtctcgatc gcgctgaccg
     5941 agaactacga caccaacggc gggctcatga tcatgccggg gtcgcacaag acgtttctcg
     6001 ggtgcgctgg ggccacgccg aaggacaact acaagaagtc gttgcagatg caggacgcgg
     6061 gcacgccgtc ggacgacgcg ctgaccctgc tggcctcgca gcacggcatc aagttgttca
     6121 cgggcaaggc cggttcggcg acgtggttcg actgcaactg catgcacggc tccggcgaca
     6181 acatcacgcc gttcccgcgc agcaacgtgt tcatcgtgtt caacagcgtg gagaacacgg
     6241 cggtggaacc gttcgcggcg ccggtgcgac gaccggagtt catcggggcg cgggacttca
     6301 cgccggtgcg gtgaacgacc ccccggccgg gggtccgggg gttggccccc ggagaacaca
     6361 gcatcggggc gcgggacttc acgccggtgc ggtgaccgct ggtcgccggt gaagtgaccg
     6421 ctgcgcgccg gtgaagtgac cgctggtcgc cggtgaagtg accggatgac acagctgccg
     6481 ggtggggcct cctcgtgtgg gacgggaggc cccgcccggt tttgtcatgc ggccaggacc
     6541 tccagcagac ggtcgacgtc cgccggggtg ttgtagaggt ggaacgccgc ccgcaggttc
     6601 cccgcccggt cggacacctg gatgcccgcg cggctcagct cttgctgccg gtggccgagc
     6661 cccgggacgg acacgatcgc cgagcccggc gcgggcaccg gcgcgtggcc cagctcggcg
     6721 agcccgacgc ggaagcggtc cgcgagggcg acgtcgtggg cgtgcacgac gtcgacgccg
     6781 atctcctcca gcagctccag ggaggcgcgc agcccggcgt aggtgaagag tgaggggctg
     6841 atgtcgaagc gccgtgcgga gtgggcgagt tcctcgaccg ggccgtagca gctctcccag
     6901 gggacctcgc cggcgaccca gccggcgagc agcggcgtga gtccgccgaa gtcctgcggg
     6961 gtgacgaaga acgcggcccc gtgcggcccg agcagccact tgaagccgac ggcggccagg
     7021 aagtcgtcgg cgtcggcctc catcggcagc cagccggccg actgggaggc gtcgacgtag
     7081 gttcgggcgc cgtgcgcccg ggccgcctcg cgcacggccg gcaggtcggc gagccggccg
     7141 tcggcggact gggcggtgct gaccgcgacg agcgcagtgc cggggcggac ggactcggcg
     7201 agccgctcca ggggaacggc gcgcaccttg aggtcgccgc gcgcgtggaa ggggttcacc
     7261 agggaggcga agtcggcctc cgcggtgagg acttcggcgc ccgcgggcag cgaggcggcg
     7321 atcagcccgc cgtactcggc gaccgaggcg ccggtggcga cccgctcggc cggcacgccg
     7381 gccagccggg cgaaacaagc gcgggcggcc tcgacgtcct cgtacagggg acccaggggc
     7441 gtgccctccg cgcgcatccg caccgcctgc tgtacggcgg tgacggtacg ggcgggcagg
     7501 agcccgttgc tcgcggtgtt gaggtaggtg tgcttcgggg cgaactcggc acggacgagg
     7561 ttctcgaagg tctccatgga accactctgc gtcccctgga tctccccgtc cattgccgat
     7621 ttctgcgtga tgccgctaag gagcgcttat aaatacgccc cgacctgcgg tttcagtgct
     7681 ggggcaccgc gcagccgtcc gggccgcacg cgtccgcgtc cccgctgtcc acgagcttca
     7741 gcggcgagcg ctcgccgtac gcctgggtca gcgcctgggc gaagacctcc gcgggctggg
     7801 caccggagac gccgtacgtg cggtcgagca cgaagaacgg cacaccgctc gcgccgagct
     7861 gcgcggcctc gcgctcgtcg gcgcgtacgt catcggcgta cgccccggca tcggcgagca
     7921 ccgcgcggac ggcctccgcg tccagcccgg cggacacggc gagctccacc agccgctcgt
     7981 cgtcgttgaa cacggagcgc tcctcggcga agttcgcccg gtacagcagg tcgaggagct
     8041 gctcctggcg cccctgctcc ttggcgaagt ggagcaggcg gtgcatgtcg aaggtgctgc
     8101 cgtggtcgcg cccccgggtg cggtagtcca gcccctcggc ggcggcctgt gcgcccaggt
     8161 tgtcctcacc ggcctcggcc tgcgcccggc tcatcccgta cttcccggtg agcatcgtga
     8221 tcacgggctg gatgtcgtcc ttggcgcggc ccgggtccag ctcgaaggag cggtgcacca
     8281 cctcgacgtc gtcacggtgc gggaagtccc gcagcgcctt ctcgaagcgg gctttgccca
     8341 cgtagcacca ggggcaggcg atgtcgctcc agatctcgac gcgcatgtct tcggctctct
     8401 ccagctcgta cggggtgcgg aggccccctc cgccgagttg gtgaacgttc aagcagccga
     8461 tttcattccg cggccaggga gagccgcatc gtcagatggt ggtccccggg ctcggccggt
     8521 tccggcaccc acccctgccg ccggtagaac ccctgcgccc gcaggttgtc gacatgcacg
     8581 tcgagaacgg cggtccgccg gccgtcggcc tgccactcct cgacgcaggc cgcgtgcagg
     8641 gcggtgccga tgccgccgcg ccagtggtcg gggtcgacgt ggaactggaa cagcttcacc
     8701 gtgtccgccg gggcgccctc gggagtccgg aaggaggcca ggccgacgat gcgccctgcc
     8761 tccaccacgc acaacacccg cccctccggc cgcgcgaggg cgctctccca gatggcgagc
     8821 cagtcggtgc cgtcctgtgg cagcccgtcg gggtagtacg tcgcccgggc acgcgcgtgc
     8881 agcgcgacga cgtccgccac ctcggcgggc aaggcggtac ggatcactct gtcgggggtc
     8941 actcggttct tgatcatgca gcggaggacg tcccccggcc gggacgtggt tccccgacag
     9001 gcttcagctg ccgtcgcgca ggtcgttcgg ccagtgcggc ctgaactcaa cgcggtcgta
     9061 cgtcaccacg cagccctccc ccatcggcga ctgggtcatg aagccgatca gggccgcgcc
     9121 cgtctccttc tcgtcgccca gcgtgaagag gcggacgaac gtccaccgtt caccgtcgcg
     9181 ggaggcgtgg aaggcgaagg cgcggccggt gcggctcacc cggagccaga cggaactgcc
     9241 gtcgacggcg aaggagttgg cgtcgtcgga gtggccccgg gtgaccaccg tgcagacggt
     9301 gggcacgtcc ggggagtact ccaggcagag cttggcccag gcgcgctcgc cgacattgac
     9361 gtagagcacc ccggcgtcga aggccgcacc gaacccgacg gtgacccggg cgatcagctg
     9421 gaagtcccct tcgggcgccc cgagcagccg aggcgcgtcg gacgcggggt ccagcccttc
     9481 cccggtgggc ggcacgaacc gatcctgccg agccccggcc cacccggtca gcaccccgtc
     9541 ctcgtaggac caatgggcct cgggcccgta ggagcgcagg gggaacggaa gttcgggaat
     9601 ctcgagatcc attcaaccga gtctttcagg tccggccctc aggggcgcgg ggaactgcgc
     9661 gatcaaccac aacgaacccg cagcccaccc gcacccctac ggcgtcaacg ctccagctgc
     9721 ccgttgaacc gccgcggcag tcccaacgga ttctcgtccc gcagctcggc cggaagcagc
     9781 gcctccggag cgttctggta gacaaccggc cgcaaccacc gctcgatcgc cgtcccgccc
     9841 accgacgtgg acgtggacgt cgtcgccggg tacggcccgc cgtgatgctg agccggcgcg
     9901 acggcgaccc ccgtcggcca gccgttcacc agcacgcgcc cggccagcgg cgtcagctcc
     9961 tggagaagct ccgcgccccg gccctggccg gcggcctcct cgtcggacag ctgcaccgtc
    10021 gccgtgaggt tgcccggcag ccgcgacagc acggccttca cctcggtctc gtcctcgtag
    10081 cgggccacca cggtgaccgg cccgaagcac tcctccagga gcaggtcgtg ctccccctcc
    10141 gccgccagcc tgctcgccgg aacggtcagg aatcccgcgc tgacggtgtg ctcgccgccc
    10201 gcgcccgggg tgaccgggga gtcgacgtcg ggcagctcgg cccgctcggc gacgccggcg
    10261 acgaagttgt cgcgcatgcg gtggtcgagc aggacccccg cgtcggtgtc gctgaccgcg
    10321 tcggtcagcg acttcagcag ggcgtcaccg gcggcgccgg ccggcgccag gacgaggccc
    10381 ggcttcacac agaactggc
//
