LOCUS       NZ_CP023702            21044 bp    DNA     linear   CON 23-APR-2024
DEFINITION  Streptomyces nitrosporeus strain ATCC 12769 chromosome, complete
            genome.
ACCESSION   NZ_CP023702
VERSION     NZ_CP023702.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces nitrosporeus
  ORGANISM  Streptomyces nitrosporeus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7581562)
  AUTHORS   Lee,N. and Cho,B.-K.
  TITLE     Direct Submission
  JOURNAL   Submitted (27-SEP-2017) Biological Science, KAIST, 291 Daehak-ro,
            Daejeon 34141, South Korea
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 2.3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 50X
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_008704555.1-RS_2024_04_23
            Annotation Date                   :: 04/23/2024 03:20:47
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,704
            CDSs (total)                      :: 6,606
            Genes (coding)                    :: 6,461
            CDSs (with protein)               :: 6,461
            Genes (RNA)                       :: 98
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 76
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 146
            CDSs (without protein)            :: 145
            Pseudo Genes (ambiguous residues) :: 0 of 146
            Pseudo Genes (frameshifted)       :: 66 of 146
            Pseudo Genes (incomplete)         :: 106 of 146
            Pseudo Genes (internal stop)      :: 16 of 146
            Pseudo Genes (multiple problems)  :: 38 of 146
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:19:57
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2462741
            Orig. end                         :: 2483785
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP023702.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria available from Korean Collection for Type Cultures.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21044
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="14"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..21044
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21044
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11044](-)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11044)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     misc_feature    complement(309..318)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     gene            1058..1591
                     /locus_tag="CP967_RS10630"
                     /old_locus_tag="CP967_10690"
     CDS             1058..1591
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019889142.1"
                     /locus_tag="CP967_RS10630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP967_10690"
                     /product="NUDIX domain-containing protein"
                     /protein_id="WP_150487748.1"
                     /transl_table=11
                     /translation="MPNNRPDEGNPVAQQTDDQSKALKPALESMTLLVAAVIVHDKVTN
                     RVVLLQRSESAKFAQGMWDLPVGKSEPGEPITETAVRELYEETGLTVKSESLKVAHIIH
                     GAWGVEAPNGFLTVVFAAHEWTGEPENREPRKHSQVRWVDVNSIPEEFVETTDSALDRY
                     LGGGPQVSLNGWAS"
     gene            complement(1611..3317)
                     /locus_tag="CP967_RS10635"
                     /old_locus_tag="CP967_10695"
     CDS             complement(1611..3317)
                     /EC_number="2.7.11.1"
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012298.4"
                     /locus_tag="CP967_RS10635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP967_10695"
                     /product="serine/threonine-protein kinase"
                     /protein_id="WP_167535361.1"
                     /sec_met_domain="Pkinase (E-value: 3.7e-51, bitscore:
                     172.6, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPGEQDELVGGRYRFVRAIGKGGMGRVWLARDETLGRDVALKSVV
                     YVDDSEASRALQRRRFIREAEVLANLRHAGIVVVHDVLKDLEPPVMVMEYVAGSSLQQL
                     LRNEGPLSVPETVGIGLAIVDALTEVHDKEVVHRDLKPANILVAGARVVVVDFGIALVK
                     GATQLTRTGAGPGSVSYMAPERLRGHRGEAPADLWSLGVILYELVEGRRPFTGEIEEAV
                     MYAICHEDPEETERAGELAPVLAGLLAREPEARLTAEQARVGLAEIARQQRPRSASDSP
                     PTPASSAVSLAALPTVTAVPGAGAAVPPQPRERTAPDVPAQVASRAEGDEPVLDARTLG
                     GLPLVRLVPALTARWEAGERDDVHAALKRVGRDWPPAELVEVAHSLRYGKYPFLADNLM
                     RYAGRLQRPAALAYLITLLRYASRDRDADEALVAAGKGRLRKELPDVEAALWARSGQVQ
                     GRAASHIDLDVGRMRDAADGRLQPSVRGAASRAQTGPDHDQSFVPFWFAVPTERQLVAE
                     DLSPSVVACLAPGTWYLAVGPYEGGNATALIAQTQDGKRGLLWNTEGIQRG"
     gene            complement(3842..4294)
                     /locus_tag="CP967_RS10640"
                     /old_locus_tag="CP967_10700"
     CDS             complement(3842..4294)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013003783.1"
                     /locus_tag="CP967_RS10640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP967_10700"
                     /product="VOC family protein"
                     /protein_id="WP_150487750.1"
                     /transl_table=11
                     /translation="MTLSWKLVIDSANAPALADFWAAALEYEVEDPDALIGQLLAAGHI
                     GEEAVTEHRGRRTFRGYAAIRHPEDPFDETSGVGRGRRLLFQDVPEAKTGKNRLHIDVH
                     SEPGGLDALVARLEGLGATRVREVDKGPAGHWWVMRDPEGNEFCAA"
     misc_feature    complement(4303..4316)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 15.88"
                     /tool="antismash"
     gene            4316..4924
                     /locus_tag="CP967_RS10645"
                     /old_locus_tag="CP967_10705"
     CDS             4316..4924
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010041456.1"
                     /locus_tag="CP967_RS10645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP967_10705"
                     /product="CGNR zinc finger domain-containing protein"
                     /protein_id="WP_150487751.1"
                     /transl_table=11
                     /translation="MNSAATTGLTLYSRTGAAYRFDPGALCLELLTTGGPGPYSRYEVL
                     REPADLAAWADRSRLTPTPVLEISADEVAAARGLRDALFGVVLARTHGEPYPAGDLEAV
                     NEAAARPALAPAVTAEGERRWTGPLTGARLASTVARDAVELLTGPFAHRIRTCASENCH
                     LVYVDTSRPGRRRWCSMEHCGNLHKVRALRSRQTGAEGG"
     gene            complement(4955..5908)
                     /locus_tag="CP967_RS10650"
                     /old_locus_tag="CP967_10710"
     CDS             complement(4955..5908)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018959105.1"
                     /locus_tag="CP967_RS10650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP967_10710"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_150487752.1"
                     /transl_table=11
                     /translation="MELEVRHLRALCAIADAGSLHQAARRLGVSQPALTTQLQRIERAL
                     GAELFSRGRTGCRPTLLGRTVLSRARPLVEGMSSLVGAALAEAEAARADGPRLRIGSTA
                     SRVIGGWLRRLRVRLPGTDISLRVDVSATALLHAVAGGRLDIAFVHEVEGCPLDVPEGL
                     VQRVLVEREPQFISLARDHPAAAQPVVDLDDLAGDRWMVDPSVDGEWDGVRRVLGAAGL
                     DPPVLHGDYLTAASLVVLGEAVAPCQPTSGPRDDMAIRPLRGDPLAVRLLLVAHPDTGM
                     DAAYEELEAAYREAAQRAAAYHQWLLRHHSPLARAV"
     gene            6211..6885
                     /gene="snpA"
                     /locus_tag="CP967_RS10655"
                     /old_locus_tag="CP967_10715"
     CDS             6211..6885
                     /EC_number="3.4.24.77"
                     /codon_start=1
                     /gene="snpA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015611282.1"
                     /locus_tag="CP967_RS10655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP967_10715"
                     /product="snapalysin"
                     /protein_id="WP_190174973.1"
                     /transl_table=11
                     /translation="MGHPRTALVSAVAGLGLAATLGISPAVAATAAPSAPAASSATAEA
                     GYAAYAGSSENAAANRAFFEAVVKSVAEKRAANPGAQVVTVVYSAANAPSFRSQIAAST
                     SIWNSSVSNVKLQEGSNADFAYYEGNDSRGSYASTNGHGSGYIFLDYAQNRQYNSTRVT
                     AHETGHVLGLPDHYSGPCSELMSGGGPGTSCTNAYPNAAERSRVNTLWQYGFAAAVARA
                     AS"
     gene            complement(6962..7318)
                     /locus_tag="CP967_RS10660"
                     /old_locus_tag="CP967_10720"
     CDS             complement(6962..7318)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1136: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007458277.1"
                     /locus_tag="CP967_RS10660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP967_10720"
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_150487753.1"
                     /transl_table=11
                     /translation="MLFRVDPSSAVPLGDQIAACARRAVADGSVAAGERLPAARALADS
                     LGVNVHTVLRGYQRLREEGLIELRRGRGAVVTAGASPLRAQLLDSVRTAVAQARELGMA
                     ENDLLALVRTELNA"
     gene            complement(7321..8298)
                     /locus_tag="CP967_RS10665"
                     /old_locus_tag="CP967_10725"
     CDS             complement(7321..8298)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014048274.1"
                     /locus_tag="CP967_RS10665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP967_10725"
                     /product="DUF1648 domain-containing protein"
                     /protein_id="WP_150487754.1"
                     /transl_table=11
                     /translation="MNHRKLVYAALGALPFVLVVLTDLALVVAVGDRLPGRVASHFSFS
                     GKADGHTGRTVFLLVTVALPVLLGAVWSFLAARDTFRGGRAYDGFLVSGYAVAGFTGYL
                     TAATLLANVDTADGGPAAALSPWQMAAAAGTAVAAAALGLLANRLLPAPPDGPEGHEGA
                     GRGARIALAEGEVAGWVRGTTSWWPALGAVALAAGGVAVTVEAGPAAGLPLVVVGAFLV
                     TFSRPNVTVDRRGLTVSGLLPWPRVRIPLERVEGATSREVKALGEYGGWGYRIRPGGSG
                     VILRSGEAIVARLKGGREFTVTIDDSATGAALLNTLAGRDRGES"
     gene            complement(8441..9109)
                     /locus_tag="CP967_RS10670"
                     /old_locus_tag="CP967_10730"
     CDS             complement(8441..9109)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018489070.1"
                     /locus_tag="CP967_RS10670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP967_10730"
                     /product="DUF6304 family protein"
                     /protein_id="WP_150487755.1"
                     /transl_table=11
                     /translation="MTDESWAGWYRDRHGSEAVILTTDGRQLRVRVRGTDFEGESFDSL
                     GPVAGPPPEAGLFDLADGVLGDCVLEWDLPLPVLVAGTVRQATLSCLLSLRRADPDLYL
                     ALHLDGAVYESNRAEGDFASALATIRRILPPDMHLQICAACALSGYLPAPARRISGGLG
                     CFRDAKDAYRDAAEDTDLAALWERRTGLVQEIWSCREFDPRPTADSDPRQLGAFLPEPA
                     "
     gene            complement(9212..9808)
                     /locus_tag="CP967_RS10675"
                     /old_locus_tag="CP967_10735"
     CDS             complement(9212..9808)
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010061503.1"
                     /locus_tag="CP967_RS10675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP967_10735"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_150487756.1"
                     /transl_table=11
                     /translation="MGVRIRQADGRDRDRIVAILEEAFHHDPVSSWVFPEETHRKAVHG
                     RFLGVFADVALAEGRVDLLEDGTAAALWLPVPAGEPEGEDTTPALMRETADPDNERAEL
                     VGRLTGAVHPHDRAHEYLLMIGVLPGCQGEGIGEALIAGVLERCDREGVPAYLEASSER
                     SRGLYERLGFAFTGRTVELPGGPSMWPMWREPRGV"
     gene            complement(10001..11044)
                     /locus_tag="CP967_RS10680"
                     /old_locus_tag="CP967_10740"
     CDS             complement(10001..11044)
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018105591.1"
                     /locus_tag="CP967_RS10680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP967_10740"
                     /product="family 2 encapsulin nanocompartment cargo protein
                     polyprenyl transferase"
                     /protein_id="WP_150491788.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 2.8e-60, bitscore:
                     202.4, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSTGTATEGHEAAALLERTRDAVGPHLRAAVETLPGAIRRVALY
                     HFGWQDADGTPTAGPSGKAIRPALVLAAARALGGDAESAMRAAVAVELVHNFTLLHDDV
                     IDEDTTRRHRPTAWALFGVPDAVIAGDALLALAQRLLAEDPHPAAMEAAARLSACVIEL
                     CAGQQADCALEEREPRDVTLDECLAMATAKTGALLGCACALGALYAGADGGTVRSMDGF
                     GRESGLAFQFIDDLIGIWGDTGRTGKPVGADLAAHKKSLPVVAALTSGTPAAGELAALY
                     GGPMNTPGEVGRAAEVIERAGGRDWAQECAADRMARAVHHLSRAVPDPATAEELLALAE
                     FVTRRTH"
     gene            complement(11172..12575)
                     /locus_tag="CP967_RS10685"
                     /old_locus_tag="CP967_10745"
     CDS             complement(11172..12575)
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010061505.1"
                     /locus_tag="CP967_RS10685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP967_10745"
                     /product="family 2B encapsulin nanocompartment shell
                     protein"
                     /protein_id="WP_150487757.1"
                     /transl_table=11
                     /translation="MSVGEEVRNTQPPQQSLGTAAARNLATTTKSAPQMQEITSRWLLR
                     MLPWVQVQGGTYRVNRRLSYSVGDGRVTFVQTGDRVAVIPAELGELPALRDFEDEEVLA
                     ELARRCEQRDVAAGEVLATAGDAADRVYLLAHGKVEKTGTGLYGDETVLGVLADGAYFG
                     DRALIDGDASWEYTTRAVTACTLLTLSRADVLNLAERADSLRTHLAGLLNIPQQRTNHY
                     GEAAIDLSAGHVGESVIPHTFVDYEAAPREYELSVAQTVLKVHSRVADLYNQPMNQTEQ
                     QLRLTVEALRERQEHEIINNREFGLLNNCDYGQRIQPHDGVPGPDDMDELLSRRRGSKL
                     FLAHPRAIAAFGRECSKRGLVPESVDVGGHHVPAWRGVPIFPCSKIPVSEARTSSIICM
                     RTGEADQGVIGLQQSGIPDEIEPSLSVRFMGIDEQAIISYLVTAYYSAAILVPDALGVL
                     ENVEVSRWR"
     misc_feature    complement(12608..12622)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.32"
                     /tool="antismash"
     misc_feature    12715..12731
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 25.06"
                     /tool="antismash"
     misc_feature    12726..12742
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.6"
                     /tool="antismash"
     gene            12751..13200
                     /locus_tag="CP967_RS10690"
                     /old_locus_tag="CP967_10750"
     CDS             12751..13200
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014154133.1"
                     /locus_tag="CP967_RS10690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP967_10750"
                     /product="Rrf2 family transcriptional regulator"
                     /protein_id="WP_150487758.1"
                     /transl_table=11
                     /translation="MRLTRFTDVALRVLMRLAVTTESGDLPTTREVAATMQVPYTHAAK
                     VVARLQHLGLVDARRGRGGGLALTSAGRSASIGGLVRELEGPGEVVDCEGSSPCPLRSA
                     CRLRSALRLAEDAFYATLDPLTVGDLTSSPTGPVLVGISSGPAPG"
     gene            13347..14543
                     /locus_tag="CP967_RS10695"
                     /old_locus_tag="CP967_10755"
     CDS             13347..14543
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1094: ferredoxin"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008741535.1"
                     /locus_tag="CP967_RS10695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP967_10755"
                     /product="globin domain-containing protein"
                     /protein_id="WP_150487759.1"
                     /transl_table=11
                     /translation="MLSETSTATVKATLPAVGAAIGDIADLFYRKLFDAHPELLRDLFN
                     RGNQASGTQRQALAGSIAAFATHLVEHPDTRPDVMLSRIANKHASLGITAPQYEIVHTH
                     LFAAIAEVLGDAVTPEVAAAWDEVYWLMANALIALEERLYAQRGVAAGDVWHEWTVVSR
                     TEDTEDVATFRITPADGTPAPAFRPGQYVSVQVELADGAHQIRQYSLTGAPGAELRSFS
                     VKRVRDEGSPEGEVSRHLHTRLREGDRLRVSVPYGDLVLEDTGAPLLLASAGIGCTPIL
                     AMLEQLVAEEHRSPVTVVHGDRSPAGHALRAGHLALAGELPDATAHFWYEHPEPGQPAQ
                     RSGLVDLSDVPLSPGTHAYLCGPLPFMRAVRGQLLAKGVAASDIHYEVFGPDLWLAQG"
     gene            14690..15280
                     /locus_tag="CP967_RS10700"
                     /old_locus_tag="CP967_10760"
     CDS             14690..15280
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014154135.1"
                     /locus_tag="CP967_RS10700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP967_10760"
                     /product="N-acetylmuramoyl-L-alanine amidase"
                     /protein_id="WP_190174972.1"
                     /transl_table=11
                     /translation="MSSPMSASKFLKALKNEGLTVVQVGDWRTHNRNHKGPWGPVHGVM
                     LHHTATKGTSRTVDICRKGYAGLPGPLCHGVITKDGRVHLVGYGRANHAGLGDDDVLRA
                     VIAEKRLPTDNESNTDGNRHFYGFECENLGDGDDPWPDAQLEAIERAAAAVCRFHRWDA
                     PSVIGHREWQPGKVDPRGFSMTAMRARIHDRLK"
     gene            complement(16133..17272)
                     /locus_tag="CP967_RS10715"
                     /old_locus_tag="CP967_10775"
     CDS             complement(16133..17272)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1087: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014150744.1"
                     /locus_tag="CP967_RS10715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP967_10775"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_167535362.1"
                     /transl_table=11
                     /translation="MGTHHPIAIIGGGLGGLTAARVLYVNGIEAAVFELEPSREARTQG
                     GMLDIHEENGQKALHAAGLHDGFLKIIHEGGQAMRLLGPDGTVHVAEEDDGTGGRPEVD
                     RGDLRDLLLDSLPDGTVHWGRKVTGARAQEGGRHEVTFADGSTITTDLLIGADGAWSRV
                     RPLLSEAVPAYTGISFVETDLLEAETRHPRSVAVVGSGFFICLGGERGFLAHKETDGSV
                     HVYTALKADEGWLDTVDFTDPPAAKQAVLAHFEGWDETLRGLIADADTMTPRRIHALPV
                     GHRWDRAPGVTLLGDAAHVMSPFAGEGANLAMLDGAELASAVATHPGDTEAALTAYEEA
                     LFPRSEASAADSAQSLETMFGPQGLEEMTALFTTGPAAR"
     misc_feature    complement(17344..17360)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 15.96"
                     /tool="antismash"
     gene            complement(17441..18136)
                     /locus_tag="CP967_RS10720"
                     /old_locus_tag="CP967_10780"
     CDS             complement(17441..18136)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1239: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014049123.1"
                     /locus_tag="CP967_RS10720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP967_10780"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_150487761.1"
                     /transl_table=11
                     /translation="MTAKREPISRRERPAKPALTRWGIVDAAVRVMRSEGLEKVTMRRL
                     AQELDTGPASLYVYVANTAELHAAVLDALLGEVELSTDRPGTGWREDLVAVLTSYTRLL
                     FEHPQLARSALVARPSGANYLDLVERLLLLLSRSGAPREQVAWGVDSLLQYATATAAEH
                     ATQEHEPMSQGDWDALTRAAHGVDEAGHPMIKAHLPTLLSGTQDARLSWGLNVVINGII
                     HTPVPDTTG"
     gene            <18503..18722
                     /locus_tag="CP967_RS34555"
                     /old_locus_tag="CP967_10790"
                     /pseudo=""
     CDS             <18503..18722
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018845368.1"
                     /locus_tag="CP967_RS34555"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="CP967_10790"
                     /product="XRE family transcriptional regulator"
                     /pseudo=""
                     /transl_table=11
                     /translation="METRFSHAEDAVNHVSLAVFRFDHDALVTPHLARLVGHDSPLLHL
                     RRQGRRRDVRPLRRACGGAVGPGPPAPV"
     misc_feature    complement(18504..18518)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.29"
                     /tool="antismash"
     gene            18757..19701
                     /locus_tag="CP967_RS10735"
                     /old_locus_tag="CP967_10795"
     CDS             18757..19701
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PALP"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012379092.1"
                     /locus_tag="CP967_RS10735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP967_10795"
                     /product="pyridoxal-phosphate dependent enzyme"
                     /protein_id="WP_229888181.1"
                     /sec_met_domain="PALP (E-value: 8e-18, bitscore: 63.4,
                     seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNRPVDPALALRPRLPSPLEEIRDERFTRYGVALLLKRDDLIHPD
                     LPGNKWRKLAPNLRAAAGRTVLTFGGAYSNHLRATAAAGRLLGFPTIGVVRGDELAHRP
                     LNPSLARCAEDGMRLHFVDRAAYRAKGSPEVLDGLLDLFGDCAVVPEGGSNAAAARGCA
                     ELGRELSGQTGRAGQAAGTVAVACGTGGTLAGLAAGLGSGQRALGIPVLRGGFLGAAVR
                     GLQREAFGGPAGRWSLDERFHFGGYARTTPELHAFAEDFEDRHGLPVERLYVAKLLYAL
                     TTLAAEGAFAPGSAVAAVITGRPGPLQDPSVSR"
ORIGIN
        1 gtcaccgacc tgggccgcgc cgacgtcgaa cgccgccgct tcctcgccat cgcagccttc
       61 accaccgccg gcgtcgccat gccgctcagc cacgaccacg aagccaccgc ccgcatgctc
      121 cgcgcccgca ccggcacgtc cctcgtcggc gcggaggacg tggacgtcgt acgccagatc
      181 accaccgcct tcagcgccgc cgacgaacgc ctcggcggcg ggcacggcct gaccaccgtc
      241 tgcgcctacc tcgccgacac agccgccccc atgctgcgcg gacgcttccc cagcgaaatc
      301 ttacgtcggg ccgccttcgg agccgtcgcc gaactcgcct acctggcgga gtggaagcac
      361 cacgacctcg atcaggaagg cgccgcccag cgctactacc aggtcggcta ccagctcgcc
      421 tgcgaagccg acccccaagg ccacgccgcc tggatgatgc gtgccctcgc ccaccaagcg
      481 ctgagcctca agcagcccca tcactgcgtc gatctcgtcg aaggcgccct acgcctgggc
      541 ctcggccacg tcgacggcca gacggaagct ctcctccaca tcacacatgc ccgcgcctac
      601 gcggccacag aggagagcgc atcagccgca cgcgccctgc tcgccgccga ggatgccctc
      661 ctacgcgacg acggccccca gcccagctac tcccgcgtga gcggccccgc cgccggcacc
      721 gtggccagcc acaccgcccg caccctgacc gacctcgccg accacatcgg caccgagcag
      781 cagcaccgcg acgccctcac ccgctgggac cccgtgaagt acaagcgcgt ccacgctctc
      841 acccacgccg acctcggcga cagtctcgcc gcccaggttc gcgccgacga agccgtcgcc
      901 gcctggaccc aggccctgag cctcatggag ggcatgacct ccgaccggac gcgcaaggcc
      961 atctcctcga tccgctccac cctcgcggtc taccagcacc ggcgagtccc cggcgtggcc
     1021 gatctcgccc gccgagcccg cgaagccctc gcctaacatg cccaacaacc gccccgacga
     1081 agggaacccc gtggcccagc agaccgacga ccagtcgaag gcgttgaagc cggcgctcga
     1141 atcgatgacc ctgctggtcg ccgccgtcat cgtccacgac aaggtcacca accgcgtcgt
     1201 tctcctccag cgcagcgaaa gcgccaagtt cgcccaggga atgtgggacc tccccgtcgg
     1261 caagagcgaa ccgggcgaac ccatcacgga gaccgcggtc cgcgagctct acgaggagac
     1321 gggcctcacg gtgaagtccg agtccctcaa ggtcgcccac atcatccacg gcgcatgggg
     1381 cgtggaggcc cccaacggct tcctcacggt cgtcttcgcc gcccacgaat ggaccggcga
     1441 acccgaaaac cgcgaacccc gcaagcactc ccaggtccgg tgggtcgacg tcaactccat
     1501 ccccgaagaa ttcgtggaga ccaccgacag cgccctcgac cgctacctcg gaggcgggcc
     1561 gcaggtctcg ctgaacggct gggctagcta accagagccc gaaaaaggac ttacccacgc
     1621 tggatgccct cggtgttcca gaggaggccg cgcttcccgt cctgtgtctg ggcgatcagc
     1681 gcggtcgcat tgcctccctc atacggccct acggccaggt accaggtgcc aggtgccagg
     1741 caggcaacta cgcttggcga caaatcctcg gcgaccagct gccgctccgt gggtactgca
     1801 aaccagaatg ggacgaacga ctggtcatgg tcgggccccg tctgcgctcg cgaggcagcg
     1861 cccctgacac ttggctggag ccgtccgtcc gccgcatctc tcatccgccc gacgtcaagg
     1921 tcgatatggg acgcggctcg tccctgcacc tgtccgctcc gtgcccacaa agctgcctcg
     1981 acatcaggca gttcctttcg gagtctgccc tttccagctg ccacgagagc ctcgtcggcg
     2041 tcgcgatcgc gtgacgcgta gcgcagaagg gtaatgaggt acgcgagggc agcgggccgc
     2101 tggagtcggc ccgcgtatcg catcaggttg tccgccagga acgggtactt gccgtaccgc
     2161 aaggagtgcg ccacttctac gagctctgcc ggaggccagt cacgtccgac acgtttcagc
     2221 gcagcatgga catcgtccct ctcccccgcc tcccatcggg cagtgagggc tggcaccaac
     2281 cgcacaagcg gcagccctcc aagggtgcgc gcatcgagga caggttcatc gccctcggcc
     2341 cttgaggcga cttgggctgg cacgtccggg gcagtccgtt cccgaggctg cggcgggacc
     2401 gcggcccctg ccccagggac agccgtgacc gtgggcagcg ccgcgaggga caccgccgag
     2461 gaggcaggcg tcggaggcga gtctgaggca ctccgcggcc tctgctgccg agcgatctcc
     2521 gcgaggccca ctcgcgcttg ctcggcggtg agtcgcgcct caggctcgcg ggcgagcagt
     2581 ccagccagaa caggagccag ttcacctgct cgctcggtct cctccggatc ctcgtgacag
     2641 atcgcgtaca tgaccgcttc ctcgatctct cctgtgaagg gacgtcgtcc ctcgacaagc
     2701 tcgtacagga tcaccccgag agaccagagg tctgccgggg cctcaccccg gtgcccgcgc
     2761 aggcgctcgg gagccatgta gctcaccgat cccggccctg cgccggtcct cgtcagctgt
     2821 gtggcgccct tgacgagggc gatcccgaag tcgacgacca ccacacgcgc accagccacg
     2881 aggatgttgg cgggtttaag atcccggtgc acgacctcct tgtcgtgcac ctcggtcaac
     2941 gcgtccacga tcgcgagccc tatcccgacg gtctctggga ccgacagcgg cccctcgttt
     3001 cgcagcagtt gctgcagcga ggagcccgca acgtattcca tgaccatgac aggtggctcg
     3061 aggtctttga ggacgtcgtg gacgacgacg atcccggcgt ggcggaggtt agctagcacc
     3121 tcagcctcgc ggatgaagcg tctccgctgg agagcccggc tcgcttcgct atcgtcgacg
     3181 tacacgacgc tcttgagggc gacatcgcgc ccgagcgtct catcacgggc cagccagacc
     3241 ctgcccatgc caccttttcc gatggctctg acgaagcgat atcgcccacc gaccagctcg
     3301 tcctgctccc caggcatggt cagcatccta gccccgaacg agatggaagc ccgcctgaac
     3361 cgaagccgcc accagtagct ccagcaggca tcgcagatcg tcggcgctct cgcccacgca
     3421 gcgcctcagc tccaagtgct gaggcgccga cacctcacag ccagagcgaa gcagtccgca
     3481 cacagtccgc aggacgcccg ctcaggaccg tcgcacccca tcgccagcca acagcaaaag
     3541 gccaggtcag cgccccacag ggaaaatccc cgcaggtcac cgacccggcc ccttactagg
     3601 agaccaagca tgcctggcct ccggccggac catgcgcccc gcgatccagc gggccgcgcc
     3661 gtccgcccac ccgcgcccgg cccccgggcc gccggacacg gcggtcgcgg cggccgggcg
     3721 cggtcgtctt cgcccctccg gttccggtgg taccgcgctt gcgcggcggg ccggtgcggc
     3781 aggggcgttc cgttgtcgcc cgcggactgc cgccccgcag gcgggacttc cggggcgcgc
     3841 cctacgccgc gcagaactcg ttgccctccg ggtcccgcat gacccaccag tggccggccg
     3901 ggcccttgtc cacctcccgt acccgggtcg cccccaggcc ctccagcctc gccaccagcg
     3961 cgtcgaggcc gccgggttcg ctgtggacgt cgatgtgcag gcggttcttg cccgtcttgg
     4021 cctcgggtac gtcctggaag aggagccgcc gcccgcggcc gacgccgctg gtctcgtcga
     4081 aggggtcctc ggggtggcgg atcgcggcgt agccgcggaa ggtcctgcgg ccgcggtgct
     4141 cggtgaccgc ttcctcgccg atgtgtccgg cggccagcag ttgcccgatg agggcgtcgg
     4201 ggtcctccac ctcgtactcc agggccgcgg cccagaagtc cgcgagggcg ggggcgttcg
     4261 cgctgtcgat gaccagcttc caactcaacg tcatgtaacc agttatattg gttacatgaa
     4321 ctccgccgca actaccgggc tgacgctgta ctcccgtacc ggtgccgcct accggttcga
     4381 ccccggcgcg ctgtgcctgg agctgctgac caccggcggc cccggcccct acagccggta
     4441 cgaggtcctg cgcgagcccg ccgacctggc cgcctgggcg gaccggtcgc ggctgacccc
     4501 gacgcccgtg ctggagatct cggcggacga ggtggccgcg gcgcgcgggc tgcgtgacgc
     4561 gttgttcggg gtggttctcg cccgtacgca cggtgagccg tacccggccg gtgacctgga
     4621 ggccgtcaac gaggcggccg cccgtccggc cctggcaccc gccgtcacgg cggaggggga
     4681 gcggcggtgg accgggcccc tcaccggcgc ccgcctggcg tccaccgtcg cccgcgatgc
     4741 cgtcgagctc ctgaccggcc ctttcgcgca ccgcatacgc acctgcgcct ccgagaactg
     4801 ccacctcgtc tacgtcgaca cctcgcgccc cggacgccgt cgctggtgct ccatggagca
     4861 ctgcggcaac ctccacaagg tcagggcgct gcgttcccgc cagaccgggg ccgagggagg
     4921 ctgaccgccc cgcccgcggg gccggcccgg cccgtcagac cgcccgtgcc agcgggctgt
     4981 ggtgtctcag cagccactgg tggtaggcgg ccgcccgctg ggccgcctcg cggtaggccg
     5041 cctccagctc ctcgtaggcc gcgtccatgc cggtgtccgg gtgtgccacc agcaggagcc
     5101 gtaccgcgag cgggtcgccg cgcagggggc ggatcgccat gtcgtcgcgg gggccggagg
     5161 tgggctggca gggggcgacc gcctcgccga ggacgacgag tgacgccgcc gtgaggtagt
     5221 cgccgtgcag gaccggcggg tccaggccgg ccgcgcccag tacccggcgg accccgtccc
     5281 actcgccgtc gaccgagggg tcgaccatcc agcggtcccc ggccaggtcg tccaggtcca
     5341 ccacgggctg cgcggccgcg gggtggtcac gcgcgaggga gatgaactgc ggctcgcgct
     5401 ccacgagtac gcgttgtaca agcccttccg gtacgtccag ggggcacccc tcgacctcgt
     5461 gcacgaacgc gatgtcgagc cggcccccgg ccaccgcgtg cagcagcgcg gtggcggaga
     5521 catcgaccct gagggagatg tcggtaccgg gcagccgtac ccgcaggcgg cgcagccagc
     5581 cgccgatgac ccggctcgcg gtggagccga tgcgcagccg ggggccgtcc gcgcgggccg
     5641 cctcggcttc ggcgagtgcg gcgccgacca gcgaggacat gccctcgacg agggggcggg
     5701 cccggctgag cacggtgcgt ccgagcaggg tcggccggca gcccgtacgt ccgcggctga
     5761 acagctccgc tcccagggcc ctctcgatcc gctggagttg ggtggtcagc gcgggctggc
     5821 tgacgcccag ccgccgtgcc gcctggtgca ggctgcccgc gtcggcgatg gcgcagagcg
     5881 ccctgaggtg acgcacctcg agctccatgc cgatgagcgt agggccgttc gtacgcccgg
     5941 cgccagatgc ccctcccgcc cgcgccccgc gcacaacgcg cttcgagcca ggggcggttg
     6001 gccctccgct tcaccccggg gggggcgccg gaccggccac acgggtgcgg gcccgcgccg
     6061 accgtggccg ggggccggtg atagggccgc gctatcgcct gctgacatca tccgcggcgg
     6121 cccgggcggg cccacactct ctgcgtacct ccacccccca ccgtccgttc accggacggt
     6181 gatccaccgg acaggcagga gaaacccccc atgggacacc cccgaaccgc cctggtgtcg
     6241 gccgtcgccg gactcggact cgccgcgacg ctcggcatct cacccgcggt cgccgccacc
     6301 gcggccccgt cggcgcccgc cgcgtcctcg gccaccgccg aggcgggtta cgccgcgtac
     6361 gccggatcga gcgagaacgc cgccgcgaac cgggcgttct tcgaggccgt ggtgaagtcg
     6421 gtcgccgaga agcgcgccgc caaccccggc gcccaggtgg tcaccgtggt ctacagcgcg
     6481 gcgaacgccc ccagtttccg cagccagata gcggccagta ccagcatctg gaacagctcg
     6541 gtcagcaacg tgaagctcca ggagggctcg aacgcggact tcgcctacta cgagggcaac
     6601 gactcccgtg gctcctacgc cagcaccaac ggccacggca gcggttacat cttcctggac
     6661 tacgcccaga accggcagta caactccacc cgggtcaccg cgcacgagac gggccacgtc
     6721 ctcgggctgc ccgaccacta cagcggcccg tgcagcgagc tgatgtcggg cggcggcccc
     6781 ggcacgtcct gcaccaacgc ctacccgaac gcggccgagc gctcccgggt caacaccctc
     6841 tggcagtacg gcttcgcggc ggccgtggcc cgcgccgcct cctgaccgga accaggcacc
     6901 ccggcgcacg gggccgctcc gcgacgtcgc ggagcggccc cgtgcccata tcgcctaccg
     6961 ctcaggcgtt cagctcggta cggaccaggg ccagcagatc gttctccgcc atgcccagct
     7021 ccctggcctg ggcgacggcc gtacggaccg agtccagcag ctgtgcccgg aggggggagg
     7081 cccccgcggt gaccaccgcg ccccggcctc tgcgcagttc gatcagtcct tcctcgcgca
     7141 gccgctggta gccgcgcagc acggtgtgga cgttgacccc cagggagtcc gcgagcgcgc
     7201 gggccgccgg caggcgctcg ccggccgcca ccgagccgtc ggccacggcg cggcgggcac
     7261 aggcggcgat ctggtcgccg agcggtaccg cggacgaggg atcgacccgg aagagcacgg
     7321 tcagctctcc cctcggtcgc ggccggccag ggtgttcagc agcgcggccc cggtggcgga
     7381 gtcgtcgatc gtgacggtga actcccggcc gcccttcagc ctggccacga tggcctcacc
     7441 ggaccggagg atgacgcccg agcccccggg ccggatgcgg tatccccacc ctccgtactc
     7501 gccgagggcc ttgacctcgc ggctcgtggc gccctcgacc cgctccagcg gtatgcgtac
     7561 ccggggccag gggagcagtc ccgagacggt gagtccacgc cggtccaccg tgacgttcgg
     7621 gcggctgaag gtcacgagga acgcgcccac cacgaccagg ggcagccccg ccgccggtcc
     7681 cgcctccacc gtcacggcga ccccgccggc cgcgagcgcg acggcaccca gcgccggcca
     7741 ccaggaggtg gtgccccgga cccagcccgc gacctcgccc tcggccagcg cgatacgggc
     7801 cccgcgcccg gccccctcgt gtccctccgg gccgtccggc ggggcgggca gcagccggtt
     7861 cgccagcagt cccagcgcgg cggcggcgac cgccgtgccg gcggcggcgg ccatctgcca
     7921 gggggagagg gcggcggccg gtccgccgtc ggccgtgtcg acgttggcca gcagggtggc
     7981 ggccgtcaga tagccggtga aaccggccac ggcgtatccg ctgacgagga agccgtcgta
     8041 cgcccggccc ccgcggaagg tgtcacgggc ggccaggaag gaccacacgg cgccgagcag
     8101 gaccggcagt gccaccgtga cgaggaggaa caccgtccgg ccggtgtgcc cgtcggcctt
     8161 cccggagaac gagaagtgac tggcgacccg gccggggagc cggtcgccga ccgcgacgac
     8221 aagggcgagg tcggtgagga cgacgaggac gaacggcagg gcgccgagag ccgcgtacac
     8281 gagtttccga tggttcatgc atacctccgt tgttcgcatg ctagtagaac aatgcgaaca
     8341 agacaacgaa ccttccgccg gcacacgaag acgccccgcc accggtgttc cggtgacggg
     8401 gcgtcagggg ccaggagccg gcttcccggg ccctcgcgct tcaggccggt tcgggcagga
     8461 aggcgcccag ctgccgggga tcgctgtcgg ccgtcgggcg ggggtcgaac tcccggcagc
     8521 tccatatctc ctggaccagt ccggtgcgcc gctcccacag ggccgcgagg tcggtgtcct
     8581 cggccgcgtc ccggtaggcg tccttcgcgt cacggaagca gccgagccct ccggagatcc
     8641 gccgggccgg cgccggcaag tagccggaca gggcgcaggc cgcgcatatc tgcagatgca
     8701 tgtccggggg caggatgcgc cggatcgtgg ccagggccga ggcgaagtcg ccctccgccc
     8761 tgttggattc atacaccgct ccgtccaggt ggagggcgag gtacaggtcc gggtcggcgc
     8821 ggcgcagcga cagcaggcag ctgagcgtgg cctgccggac cgtgccggcc accaggaccg
     8881 gcagcggcag gtcccactcc agtacgcagt ccccgaggac cccgtccgcc aggtcgaaca
     8941 gtcccgcttc gggcggcggt ccggccaccg ggccgaggct gtcgaagctc tccccctcga
     9001 agtccgtccc ccggacccgg acgcggagct gccgtccgtc tgtggtgagg atgacggcct
     9061 cggaaccgtg acggtcccgg taccagcctg cccacgactc atctgtcatg agcagggact
     9121 gtagccgctt cccccgcccc gccccctgcc gccctcccct cccgtcggcc gccccgggcc
     9181 cgtacggcga aacgcctggt aggagcggta gtcagacacc gcggggttca cgccacatgg
     9241 gccacatcga aggtccgccg ggaagctcca ccgtccggcc cgtgaaggcg aagccgagac
     9301 gttcgtagag cccgcggctg cgctcgctgc tcgcctccag ataggcgggg acgccctccc
     9361 ggtcgcagcg ttccaggact ccggcgatca gcgcctcccc gatgccttcg ccctggcacc
     9421 cgggaaggac gccgatcatc agcaggtact catgggcacg gtcgtgcggg tggacggcac
     9481 cggtcagcct gcccaccagt tcggcccgct cgttgtcggg gtcggcggtc tcccgcatca
     9541 gcgcgggcgt ggtgtcctcc ccctcgggct cacccgccgg caccggaagc cagagggcgg
     9601 cggccgtgcc gtcctccagc aggtcgaccc gcccctcggc cagcgcgacg tcggcgaaga
     9661 caccgaggaa cctgccgtgc accgccttcc ggtgcgtctc ctcgggaaac acccagctgc
     9721 tcaccgggtc gtggtggaac gcctcctcca ggatcgccac gatccggtcc ctgtcccgcc
     9781 cgtccgcctg ccgtatccgt acgcccatga ccggccccgc ccctcagtac cctcgtgatg
     9841 atctcaactg gcatacgaga tcctagggtt ggcgacggaa gccggtcatc ggcgccgccc
     9901 tgcgggaggg ggggcatctg ttcccggtgc gcaccgggaa cagatgcccc actccctcag
     9961 cgcgtcctcg gtgcgccttc agccggtgtc cggccggcct tcagtgcgtc ctgcgcgtca
    10021 cgaactccgc cagggccagc agctcctcgg cggtggccgg atcgggcacg gcgcgggaga
    10081 ggtggtgcac ggcccgcgcc atccggtcgg ccgcgcactc ctgtgcccag tcccggccgc
    10141 cggcccgctc gatcacctcc gccgcccggc cgacctcgcc gggcgtgttc atggggcccc
    10201 cgtagagcgc ggccagttca ccggcggccg gtgtacccga ggtgagcgcg gccaccaccg
    10261 gcagggattt cttgtgggcg gcgaggtccg cgccgaccgg tttgccggtg cggccggtgt
    10321 ccccccagat gccgatcagg tcgtcgatga actggaaggc cagaccggac tcccggccga
    10381 aaccgtccat gctcctgacc gtccccccgt cggccccggc gtacagggcg ccgagagcgc
    10441 aggcgcagcc gagcagggcg cccgtcttgg cggtggccat cgcgaggcac tcgtcgaggg
    10501 tgacgtcgcg gggttcgcgc tcctccagcg cgcagtcggc ctgctgcccg gcgcacagtt
    10561 cgatcacgca ggcggagagc cgggccgccg cctccatggc cgcggggtgc gggtcctccg
    10621 ccagcagccg ctgcgcgagg gcgagcaggg cgtcacccgc gatgaccgcg tcgggcactc
    10681 cgaacagggc ccatgccgtg ggccggtgcc tccgggtggt gtcctcgtcg atgacgtcgt
    10741 cgtggagcag agtgaagttg tggacgagct ccaccgccac ggccgcccgc atcgccgact
    10801 ccgcgtcacc gcccagcgcc cgggcggcgg cgaggacgag cgcgggtctg atggccttgc
    10861 cggacggccc cgcggtgggt gtgccgtccg cgtcctgcca gccgaagtgg tagagggcga
    10921 ccctgcggat cgctccgggc agcgtctcca ccgccgctct gaggtgcggg ccgacggcat
    10981 cgcgggtgcg ctccaggagc gccgccgcct cgtgcccttc cgtcgcggtg cccgtactgg
    11041 tcatggacac ggtcagtcct tcctggcgcc tcacgggcgc cgtggtcgcg gccggacgcg
    11101 gcctgcgccg cacacggccc cggggcgggc ggggcgggca ccgccctggt ccaccccggg
    11161 gccgccgggg gtcaacgcca gcggctcacc tcgacgttct ccagtacgcc gagggcgtcc
    11221 ggcaccagga tcgcggcgga gtagtaggcg gtcaccaggt aggagatgat cgcctgctcg
    11281 tcgatgccca tgaagcggac cgacaggctc ggctcgatct cgtccgggat gccgctctgc
    11341 tggagcccga tgaccccctg gtccgcctcc ccggtcctca tgcagatgat cgaggacgtg
    11401 cgggcctcgg acaccgggat cttgctgcac gggaagatcg gtacgccgcg ccaggcgggc
    11461 acgtgatggc cgccgacgtc cacgctctcc ggcaccagcc cgcgcttgct gcactcccgc
    11521 ccgaaggcgg cgatggcgcg cgggtgggcg aggaacagct tggagccgcg ccggcgggag
    11581 aggagctcgt ccatgtcgtc gggaccggga accccgtcgt gcggctggat cctctgcccg
    11641 tagtcgcagt tgttgagcag tccgaactcg cggttgttga tgatctcgtg ttcctggcgc
    11701 tcgcgcagcg cctcgaccgt gagccgcaac tgctgctcgg tctggttcat cggctggttg
    11761 tagaggtcgg cgacccggct gtgcaccttc agcacggtct gcgcgacgct cagttcgtac
    11821 tcccggggcg ccgcctcgta gtcgacgaac gtgtgcggga tgacgctctc ccccacgtgc
    11881 ccggccgaca ggtcgatcgc cgcctcgccg tagtggttgg tccgctgctg cgggatgttc
    11941 agcagtccgg cgagatgggt gcggagcgaa tccgcgcgtt cggcgaggtt gagcacgtcc
    12001 gcacggctga gggtcagcaa ggtgcaggcg gtgacggcgc gcgtggtgta ctcccacgag
    12061 gcgtccccgt cgatcagggc gcggtcaccg aaataggcac cgtcggcgag gaccccgagc
    12121 accgtctcgt cgccgtagag gccggtgccg gtcttctcca ccttgccgtg tgccagcagg
    12181 tagacgcggt ccgccgcgtc ccccgccgtc gcgagcacct cgccggcggc cacatcgcgc
    12241 tgttcgcacc tgcgggccag ctcggcgagc acctcctcgt cctcgaagtc ccgcagagcg
    12301 ggaagttcgc cgagctccgc ggggatgacg gcgacccggt cgccggtctg gacgaaggtc
    12361 acccgcccgt ccccgaccga atagctcagc cgccggttca cccggtaggt cccgccctgt
    12421 acctgcaccc acggcagcat gcgcagcagc caccgggagg tgatctcctg catctgcggg
    12481 gcggacttgg tcgtcgtcgc gaggttccgc gcggccgccg tgccgagact ctgctgcggc
    12541 ggctgcgtgt tgcgaacctc ttcaccaacg gacatccgac atcctctcaa tcatgggctg
    12601 acctgcgtga agaagccttt cagcaggggg tgccacgcgc tattacacaa aagagtgcga
    12661 ttaatcagct tcgaactggg caggctgccg gcgtcgctgt ccgcgcgcct taagttgcat
    12721 aggagatgca agttatctac tgtgaccccc atgcggctga ccagattcac cgacgtggcg
    12781 ctccgggtgc tcatgcgcct ggccgtcacc acggagagcg gggacctgcc gaccacccgg
    12841 gaggtggcgg ccaccatgca ggtgccgtac acccacgcgg ccaaggtcgt cgcccgcctc
    12901 cagcacctcg gcctggtcga cgcacgccgc ggccgcggcg ggggcctggc cctcacgtcc
    12961 gccggccggt ccgcctccat cggcggcctg gtgcgcgaac tggaaggacc gggagaggtc
    13021 gtcgactgcg aaggcagctc cccctgcccc ctgcgctcag cctgccgcct ccgctccgcc
    13081 ctgcgcctgg ccgaggacgc cttctacgcc accctcgacc cgctcacggt cggggacctc
    13141 acctcctccc ccaccggccc ggtcctcgtc ggcatcagca gcggccccgc acccggctga
    13201 tccgccccgg ccccctccac gcgcgcccca ccgcgcaccg gttccaccac gggccggttc
    13261 cgccgcccaa aaatacgcat ttcacatacc aattagagtc cggccgccac ggccggcccg
    13321 cccactcgca accgaggagt cacccgatgc tctccgagac gtcgaccgcc accgtcaaag
    13381 ccaccctccc cgcagtcgga gcggccatcg gtgacatcgc cgacctcttc taccggaagc
    13441 tgttcgacgc ccacccggag ctgctccggg acctgttcaa ccggggcaac caggcgtccg
    13501 gcacccagcg ccaggcgctg gccggctcca tagccgcctt cgccacgcac ctcgtggagc
    13561 acccggacac ccgcccggac gtgatgctga gccggatagc caacaagcac gcctccctgg
    13621 gcatcaccgc cccgcagtac gagatcgtgc acacccacct cttcgcggcg atcgccgagg
    13681 tcctcggcga cgcggtcacc cccgaggtcg ccgccgcctg ggacgaggtc tactggctga
    13741 tggccaacgc cctgatcgcc ctggaggaac gcctctacgc ccagcggggc gtggccgccg
    13801 gcgacgtgtg gcacgagtgg accgtggtct cccgcaccga ggacaccgag gacgtggcca
    13861 ccttccggat cacccccgcc gacgggaccc cggcccccgc cttccgcccc ggccagtacg
    13921 tctccgtcca ggtggaactc gccgacggcg cccaccagat acgccagtac agcctcaccg
    13981 gcgcccccgg cgccgaactc cgctccttca gcgtcaagcg ggtccgcgac gagggctcgc
    14041 ccgagggcga ggtctcccgg cacctgcaca cccggctgcg cgagggcgac cggctgcgcg
    14101 tctcggtacc gtacggcgac ctggtgctgg aggacaccgg cgcaccgctg ctcctcgcct
    14161 ccgccggcat cggctgcacc ccgatcctcg ccatgctcga acagctcgtg gccgaggaac
    14221 accgctcgcc tgtcaccgtc gtacacggcg accggtctcc cgccgggcac gccctgcggg
    14281 ccggccacct ggccctcgcc ggcgaactcc ccgacgccac cgcccacttc tggtacgagc
    14341 accccgagcc cggccagccg gcgcagcgct ccggcctcgt cgacctgagc gacgtccccc
    14401 tctcccccgg cacccacgcc tacctctgcg gccccctgcc cttcatgcgc gcggtccgcg
    14461 gccagctgct ggccaagggt gtcgcggcct cggacatcca ctacgaggtc ttcggccccg
    14521 acctgtggct ggcccagggc tgaccccctc cgtacgcccg gacgctcgcg ggctgtccgg
    14581 atcggctcgc acacggcttc gcacagaacg cgaccctgta gcccggagag cggcattccg
    14641 gtacaagcgg tatagagggc acactcccca cgtaccgaag gagccggcca tgtcgtcacc
    14701 catgtccgcg agcaagttcc tcaaggccct gaagaacgaa ggactcaccg tcgtccaggt
    14761 gggcgactgg cgcacccaca accgcaacca caaagggccc tggggcccgg tacacggggt
    14821 gatgctccat cacaccgcca ccaagggcac ctcccgtacc gtcgacatct gccgcaaggg
    14881 gtacgcgggc ctgccgggcc ccctctgcca cggcgtgatc accaaggacg gccgggtcca
    14941 cctggtcggt tacggacgcg ccaaccacgc cggtctcggc gacgacgacg tcctgcgcgc
    15001 cgtcatcgcc gagaagcggc tgcccaccga caacgagagc aacaccgacg ggaaccgcca
    15061 cttctacggg ttcgagtgcg agaacctcgg cgacggcgac gacccgtggc ccgacgccca
    15121 gctggaggcc atcgagcggg ccgccgccgc cgtctgccgc ttccaccgct gggacgcccc
    15181 ctcggtgatc ggccaccggg agtggcagcc cggcaaggtg gacccgcgcg gcttctcgat
    15241 gaccgcgatg cgcgcccgca tccacgaccg gctgaagtga ccccggaccg ccgccccggc
    15301 cgggggcgtg ccccgacccc tgcgaggggg cgcgccccgg ccggggcgac aatggccggg
    15361 tgaaccggcc cgtggacccc gcccccgtac tccgcccccg gctcccctcc ccgctggagg
    15421 aggtccccga cgagcgtttc acccggtacg ggcgcatccc cgggtaagtg gagaagagcg
    15481 ggaccggccg gccccgccct cctttgccgc tgtcccttcc ggcgccggat gagcacgcag
    15541 ggccatctgg agccgtcagg gcctccgtca ggcagagagc catcctggga tgccgttaac
    15601 gagcggcgaa ccaggtgaca agtaacccgc aagtagcttc ctggtcgggt tttcacttct
    15661 ctgggtggct tgtccggctg atgggtgtgc tgctggtccg gcgccacggc ttctcgtact
    15721 tgccgccgca cacccggcac cgggggaggc agcggggccc atctgatcgc tgggctccgc
    15781 ggggtacccg gcattctgga ttctcgcgac gagatgcggg gtcgtgcagg tgcagatgtg
    15841 cacgctcgac gagatgcgcg ggcaggatcc ggcagggcct gggggcgggg cgtcgacgaa
    15901 gccggtccgg ctggggaaga acaggggagg ccggccagga gccggaaggc gcggccgcgt
    15961 acccacccgg ggccgcggcc ggtgcgggtg caggtgctgc tgagaatgat cgcggtcttc
    16021 ggcaacgtga ctcctgtggg cgagagcttt ccgggcgggg ggagagccgc gtgcggcggg
    16081 cgcaccggcg ccgtggggaa ggccggcggg cccgccgctg cgtggccggg ggtcaccggg
    16141 ccgccggtcc ggtggtgaag agcgccgtca tctcctccag gccctgcggg ccgaacatcg
    16201 tctccaggct ctgggcggag tcggcggcgg aggcttcgct gcgcgggaag agggcttcct
    16261 cgtaggcggt cagggcggcc tcggtgtcgc cggggtgggt ggcgacggcc gaggcgagtt
    16321 cggcgccgtc gagcatggcg aggttcgcgc cctctccggc gaagggcgac atcacgtgag
    16381 cggcgtcgcc gagcagggtc acacccggcg cgcgatccca gcggtggccc accggcagtg
    16441 cgtggatacg gcgcggggtc atggtgtccg cgtcggcgat caggccgcgc agggtctcgt
    16501 cccagccctc gaagtgggcg agcacggcct gcttggcggc cggcggatcg gtgaagtcga
    16561 ccgtgtccag ccagccctcg tccgctttga gggcggtata gacgtggaca ctgccgtcgg
    16621 tctccttgtg ggcgaggaag ccgcgctcgc cgccgaggca gatgaagaac ccgctgccga
    16681 cgacggccac gctgcgcggg tggcgggtct cggcctccag caggtcggtc tccacgaagg
    16741 agatgccggt gtaggcgggc acagcctcgg agagcagggg acggacgcgt gaccaggcgc
    16801 cgtcggcgcc gatcagcagg tcggtggtga tggtggagcc gtcggcgaag gtcacctcgt
    16861 ggcgtccgcc ctcctgggcg cgggctccgg tgaccttcct gccccagtgg actgtgccgt
    16921 cgggcaggga gtcgaggagc aggtcgcgca ggtcgccgcg gtcgacctcg ggccggccgc
    16981 cggtaccgtc gtcctcttcc gcgacgtgga cggtgccgtc ggggccgagc aggcgcatgg
    17041 cctggccgcc ctcgtggatg atcttgagga agccgtcatg gaggccggcg gcgtgcaggg
    17101 ccttctggcc gttctcctcg tggatgtcga gcatgccgcc ctgggtgcgg gcctccctgg
    17161 acggctccag ctcgaagacg gccgcctcga tgccgttcac gtacagaacg cgggcggcgg
    17221 tgaggccacc gaggcctccg ccgatgatcg cgatggggtg gtgcgtgccc atgggaggcc
    17281 tcctgggggt gggggacgat gccgcaggcg ccctcatcag cctgcccctc caccgtaacg
    17341 aacatgttcg ttacgaacaa gttcttcagt gggtgtgccg cgacccctcc cgcggccttc
    17401 gcgcgcggac cgtctgccgg cagcgggaat ccgcgagagc tcagccggtg gtatccggta
    17461 ccggggtgtg gatgatcccg ttgatcacga cgttgaggcc ccaggacagg cgggcgtcct
    17521 gggtgccgga cagcagtgtc ggcaggtgcg ccttgatcat cgggtgcccg gcctcgtcca
    17581 ccccgtgcgc ggcacgggtg agcgcgtccc agtcgccctg gctcatcggc tcgtgttcct
    17641 gcgtagcgtg ctccgccgcg gtcgcggtcg cgtactgcag gaggctgtcc acgccccagg
    17701 cgacctgctc gcgtggggcg ccgctgcggg agagcaacag cagaaggcgt tcgaccaggt
    17761 cgaggtagtt cgcgccgctg gggcgtgcga ccagggcgga gcgggccagc tgaggatgct
    17821 cgaagagcag acgggtgtag gaggtgagga ccgcgacgag atcctcacgc cagccggtcc
    17881 caggccggtc ggtggacagc tccacctcgc ccaggagcgc gtccagcacc gccgcgtgca
    17941 gctcggcggt gttggccacg tagacgtaga gcgaggccgg gccggtgtcc aactcctggg
    18001 ccaggcgccg catggtcacc ttctccagcc cctcggaccg catgacccgc accgccgcat
    18061 cgacgatccc ccaccgcgtc agggccggct tcgcggggcg ctcacgccgg ctgatcggtt
    18121 ctcgcttcgc agtcatacct cgatcgtaac gaacatgttc gtcgccccga ggggtgcgga
    18181 atcgcgtctc accccgaaaa ccccgcggag ccggcgccct gggcgggctc cttcatcgcg
    18241 ggagcaccgg accggtacgc ccgtcaggcc accggccggg caagggcgag caccgccagt
    18301 gccaccggca ccacggtgcc gaacccctcc gggtcccgca cccccggggc cgccgccagg
    18361 acgcccacga ccactagcgc cggcccgacc gctcccaagg tccagcgccg cggccagcgc
    18421 tccgcccgct cctccgcacg gcccgcttct ggtcgatctc gacctggagc gcctcacggc
    18481 tgacgcgcac catgactgcc atatggagac gcgtttcagc catgccgagg acgcggtgaa
    18541 ccatgtatcc ctggctgtgt tccgcttcga tcacgacgca ctcgtcacac ctcatctggc
    18601 ccggctcgtc ggacacgact ccccactcct ccacctgcgc cgccagggga gacggcggga
    18661 tgtccgaccg cttcgccgag catgcggagg agctgtgggg ccggggcccc cggcccctgt
    18721 gagggggcgc gccccggccg gggcgacaat ggccgggtga accggcccgt ggatcccgcc
    18781 ctcgcactcc gcccccggct cccctccccg ctggaggaga tccgcgacga gcgtttcacc
    18841 cggtacgggg tggctctgct gctgaaacgg gacgacctga tccacccgga tctgccgggc
    18901 aacaagtggc gcaaactcgc ccccaatctg cgggccgccg cggggcgtac cgtgctgacc
    18961 ttcggcgggg cctactccaa ccacctgcgg gccaccgccg cggccgggcg gctcctcggc
    19021 ttccccacca tcggtgtcgt acggggggac gagctggcgc accgcccgct gaacccgtcc
    19081 ctcgcccggt gcgccgagga cgggatgcgc ctgcacttcg tggaccgggc ggcctaccgc
    19141 gcgaagggct cccccgaggt cctggacggc ctgctggacc tcttcgggga ctgcgcggtc
    19201 gtcccggagg gcggcagcaa cgccgccgcc gcgcggggct gcgcggagct cggccgcgag
    19261 ctgtccggac agaccgggcg ggccgggcag gccgccggta cggtcgcggt ggcctgcggc
    19321 accggcggca ccctggccgg gctggccgca gggctcgggt ccgggcagcg cgccctgggc
    19381 ataccggtgc tgcggggcgg tttcctcggg gccgccgtgc gcggcctcca gcgggaggcg
    19441 ttcggcgggc ccgccgggcg gtggtcgctg gacgagcgct tccacttcgg cggctacgcc
    19501 cgtacgacac cggaactgca cgccttcgcc gaggacttcg aggaccggca cggactgccc
    19561 gtcgaacgcc tctacgtcgc caaactgctg tacgcgctga ccacgctggc cgccgagggc
    19621 gccttcgcgc cgggatcggc ggtcgccgcg gtgatcacgg ggaggcccgg cccccttcag
    19681 gacccgtccg tctcccggta ggccgcggcc tcctccaggt ccagccggcg cagcagggtc
    19741 cgcagcatct cgtcgtcgat ccgccgttcg tccctgagcc ggacgaagac ctcgcgctcg
    19801 gccccgatca tctcgcgtgc cagacgccgg taggtgtcgt ccgccgactc gccggtgacc
    19861 gggtcgaacg ccccgagccg ctcccacacg gcgttgcggc gccgttccat gacggtgcgc
    19921 agccggtccg cgaggggtcc gggcagctgg ttgcgcgggt cggccagcag ggcgtccagc
    19981 cgggcctcgg cggcggtgga cgcctcgctc tgcgcctgcg cctcggccag tgtctcggcc
    20041 gtcgggtcgc gtcccggcag cttcagcacc cgcaccagga cgggcagggt gagcccctgg
    20101 acgaccagcg tgccgatgac ggtggtgaag gtcaggaaca gcacgaggct gcgggccggg
    20161 aagggctccc cgtcgtgcgt ggccatcggg acggagaagg cgatggcgag cgagacgacc
    20221 ccgcgcatcc cggcccagct gacgatcagc ggcgaggtcc acggcatcgc gggctcgcgc
    20281 tccctgatcc gcctcaggag ccggcgcggg aggtaggtcg ccgggtagac ccagacgaag
    20341 cgcaccacga ccaccgcggc gaacaccgcg accgcgtaac cggccgcctc ggtgacgccg
    20401 tacgcgccga gttcccgcag cacgaagggc agctggaggc cgatgagcgc gaacaccgag
    20461 gactccagga cgaaggcgac catcttccag accgccgcct cctggagccg ggtcgcgaag
    20521 tccacctgcc aggagcggtg ccccaggtac agcgcgacga cgaccacggc gagcaccccc
    20581 gaggcgtgca cccgctccgc cgccgcgtac gcgacgaagg ggatcagcag cgacagggtg
    20641 ttctggagca gcgcctccct gaggtgggtg cgcagccagt gcagcggcac catcaggacc
    20701 agtccgacgc cgactccccc gccggccgcc agcaggaact cgccgatgcc ggcgccccag
    20761 ctcatgccct cgccgacggc ggcggccagg gcgaccttga aggcggtgat cgcggtggcg
    20821 tcgttcacca gggactcgcc ctggaggatc gtggtgacac gggcgggcag tccgaccctg
    20881 cgggcgatgg cggcggccgt caccgcgtcg ggcggggcca cgatcgcgcc gagcaccagg
    20941 gcggcggtca ggggcaggcc gggcacgacg aggtgggcca gccaccccac ggcgacggtc
    21001 gcgaacagca cgtagccgac ggagagcagg gcgaccggcc gcac
//
