LOCUS       NZ_CP023702            11320 bp    DNA     linear   CON 23-APR-2024
DEFINITION  Streptomyces nitrosporeus strain ATCC 12769 chromosome, complete
            genome.
ACCESSION   NZ_CP023702
VERSION     NZ_CP023702.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces nitrosporeus
  ORGANISM  Streptomyces nitrosporeus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7581562)
  AUTHORS   Lee,N. and Cho,B.-K.
  TITLE     Direct Submission
  JOURNAL   Submitted (27-SEP-2017) Biological Science, KAIST, 291 Daehak-ro,
            Daejeon 34141, South Korea
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 2.3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 50X
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_008704555.1-RS_2024_04_23
            Annotation Date                   :: 04/23/2024 03:20:47
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,704
            CDSs (total)                      :: 6,606
            Genes (coding)                    :: 6,461
            CDSs (with protein)               :: 6,461
            Genes (RNA)                       :: 98
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 76
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 146
            CDSs (without protein)            :: 145
            Pseudo Genes (ambiguous residues) :: 0 of 146
            Pseudo Genes (frameshifted)       :: 66 of 146
            Pseudo Genes (incomplete)         :: 106 of 146
            Pseudo Genes (internal stop)      :: 16 of 146
            Pseudo Genes (multiple problems)  :: 38 of 146
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:19:57
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1309785
            Orig. end                         :: 1321105
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP023702.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria available from Korean Collection for Type Cultures.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..11320
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="7"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11320
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11320
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6320](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..6320
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    complement(140..155)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.03"
                     /tool="antismash"
     misc_feature    941..954
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 12.7"
                     /tool="antismash"
     gene            <1081..>1176
                     /locus_tag="CP967_RS34515"
                     /old_locus_tag="CP967_05760"
                     /pseudo=""
     CDS             1081..>1176
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014153326.1"
                     /locus_tag="CP967_RS34515"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="CP967_05760"
                     /product="polysaccharide deacetylase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MAFAAVRGTGARHVVPYPRFPGGCHKDAAPRA"
     gene            complement(1243..1422)
                     /locus_tag="CP967_RS05730"
                     /old_locus_tag="CP967_05765"
     CDS             complement(1243..1422)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014049036.1"
                     /locus_tag="CP967_RS05730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP967_05765"
                     /product="hypothetical protein"
                     /protein_id="WP_150486903.1"
                     /transl_table=11
                     /translation="MDDAYCATPERPPVPGPVEGPFAECVLCREPTEYPESAKGATLCP
                     VCAWQEAGRTACSG"
     gene            complement(1476..3179)
                     /locus_tag="CP967_RS35190"
                     /old_locus_tag="CP967_05770"
     CDS             complement(1476..3179)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015579258.1"
                     /locus_tag="CP967_RS35190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP967_05770"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_150486904.1"
                     /transl_table=11
                     /translation="MVRGADLVLPRGTLIRLQGANGTGKSTLLRLLAGIDAPTEGRAEG
                     RPRTAYVPERFPAALPFTAAGYLVHLGRVHGLGTAEAARRAERWLTRFDAAEYARTPLA
                     ELSKGSSQKVAVVQALMAEPDLLVLDEAWTGLDAAAREELDRAVGERVAAGATVVFVDH
                     DPRRLAGSVDAVYLLGGGRLTAVPAASAGAVGPAGTTGPTASAGTVGPAGAAGASRVRI
                     EATAPPGATLPPRLPGAPACQRDPDTPGRVLLTVATAHSDRLLRTLLTSGEPWHITRLT
                     PEPAPEAARTSDGPPAPDESTATAAGPAGPDGGRRGHTEAAAPAPPVRPGAPRPAGVPR
                     APGRRLGPLLRCQAALLARSQRWLAPVLLYAAFAGIGIQAGQPLLDSLGYAAAALLPAG
                     AWLARLCVTQEPPASRDVTAAAAGPGRAHLAALLTALGCTLALGVAATGLVLLTGAPVG
                     NDRTTGIPLPSAALAGLLATASCALVGTAIGALCARPVLHRRGRSLAATVLGTLLALVA
                     GGSPARSAVTDLVSGSQDGTVRLPLAASGAAMLLAVAVAWFTARLTAVRE"
     gene            complement(3224..3901)
                     /locus_tag="CP967_RS05740"
                     /old_locus_tag="CP967_05775"
     CDS             complement(3224..3901)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014153329.1"
                     /locus_tag="CP967_RS05740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP967_05775"
                     /product="AIM24 family protein"
                     /protein_id="WP_150486905.1"
                     /transl_table=11
                     /translation="MKSDLFSSEHLAEQATAPGMTLQNAKSIKYAVNGEMHARQGSMIA
                     FRGNLQFERKGQGIGGMLKRAVTGEGLPLMAVRGQGEAWFAHEAANCFIVEMEQGDVLT
                     VNGRNVLCFDAGLSYEIKTVKGAGMAGGGLFNSVFSGYGKLGLICDGHPIVIPVTAQQP
                     VYVDTDAVVGWSAQLNTSLHRSQSFGSMVRGGSGEAVQLMLQGEGFVIVRPSELKQEKA
                     SSS"
     gene            4102..4839
                     /locus_tag="CP967_RS05745"
                     /old_locus_tag="CP967_05780"
     CDS             4102..4839
                     /EC_number="3.1.1.29"
                     /GO_function="GO:0004045 - aminoacyl-tRNA hydrolase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003997025.1"
                     /locus_tag="CP967_RS05745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP967_05780"
                     /product="aminoacyl-tRNA hydrolase"
                     /protein_id="WP_150486906.1"
                     /transl_table=11
                     /translation="MSSDDVPEPLPTASADSPFRVEPAPRDEAPQFVLPLVVRLEKTDP
                     PARTDALRTAARAVLTILSDERSLGDGEWAEAVRDWQDARIRKVVRRARGAEWRKASAL
                     PGITVTGEHAEVRVFPPVPLDGWPKELAKLQVSGTELDDPEPPPVPDGSKPVLWLNPGL
                     GMSAGKTMAQAGHGAQLAWWGLSDTEREAWRAAGFPLDVAAPDEVRWRELTGSGLPVVR
                     DAGFTEIEPGSCTVVADHPALRR"
     gene            5001..6320
                     /locus_tag="CP967_RS05750"
                     /old_locus_tag="CP967_05785"
     CDS             5001..6320
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014153332.1"
                     /locus_tag="CP967_RS05750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP967_05785"
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_150491717.1"
                     /sec_met_domain="DUF692 (E-value: 1.1e-90, bitscore: 302.1,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGLGIGIGWRPEIADAVEELPGIDWVEAVAENLCDDHLPGPLARL
                     RERGVTVVPHGVSLGLGGAGRPDPGRLAALAARATLLGAPLVTEHIAFVRAGGPLTASP
                     GLEAGHLLPVPRTWDALDVLCENVRIAQDALPVPLALENIAALVSWPGEELTEGQFLAE
                     LVERTGVRLLIDVANLHTNHVNRGEDPVAALDELPVEAIAYVHVAGGIEKDGVWHDTHA
                     HPVTRPVLDVLAELRSRTDPPGVLLERDDDFPPAGELAGELAAIRTTLATAPPAPPPVP
                     RARAPRPAPAGGARDRVAVAQTALLSALVAGAPAPEGFDRRRLGVQSRALAAKRADVVA
                     KVAPELPEILGEGYRPAFLAYAGSRPQTGGYRRDALDFAEHLLIAGAPADGAARDMLTA
                     WWRDRASPRPPRRAARLLRAAGGTRVVRAARGVLGGRWAG"
     gene            6317..7318
                     /locus_tag="CP967_RS05755"
                     /old_locus_tag="CP967_05790"
     CDS             6317..7318
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015612179.1"
                     /locus_tag="CP967_RS05755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP967_05790"
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_190175144.1"
                     /transl_table=11
                     /translation="MTVLSALAVLLTAVVAVLCVCVLRPSRGPAGRSADASEVHDVFEA
                     AFLSGGPARTVDTALTALYADGRLEIGGPGIVAVRRAEARDAVERAVLRELAAAPSGAL
                     DALRTAVMRHPAVQEVGDGLAARGLLAAPGDDRGRRTLARVLAAGSGVALPVSIVLTVL
                     EYLLLTDFDDMPFPFAAKVLPAIMAGIVVGLIGAPSAGSRITPAGRRAAARYRNARAQE
                     DDPVLLVATRGPAALPYTELRERLSAAARTSRRHPSPLLATGGPSDGGVPPPVWCAGTD
                     PGHEGCGAGGDPGTGSSCGSGGGDGGGSSCGSGSSCGGGSSCGGGGGCGSSS"
     misc_feature    7410..7425
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 16.86"
                     /tool="antismash"
     misc_feature    7415..7435
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 20.2"
                     /tool="antismash"
     gene            7477..8262
                     /locus_tag="CP967_RS05760"
                     /old_locus_tag="CP967_05795"
     CDS             7477..8262
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014153334.1"
                     /locus_tag="CP967_RS05760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP967_05795"
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_150486907.1"
                     /transl_table=11
                     /translation="MLWVLFLLVAWGAAAVSCIRLCLVTANAAPRPGDAADGPPPRELS
                     LYETAFLAGGPHRVADLALVSMHLRRGLLLAHTGWATVVDPEGRDEVERTVIRAIGPQG
                     QSRIAPIRAAAAAADTVRALADRLVAAGLAVPHGTRTTLESAARGVRGAAVLVVVLAVA
                     TVLMPGQETGDTGPVVAWFGLPLVLTLGCLAIARVESHPYSPWASPSGQRWLDSLPAPA
                     HGADRDVLAAVAVRGAAAVPDPGLRAALLGSAHGSRTGV"
     gene            complement(8663..9376)
                     /gene="hemQ"
                     /locus_tag="CP967_RS05765"
                     /old_locus_tag="CP967_05800"
     CDS             complement(8663..9376)
                     /EC_number="1.3.98.5"
                     /codon_start=1
                     /gene="hemQ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018888541.1"
                     /locus_tag="CP967_RS05765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP967_05800"
                     /product="hydrogen peroxide-dependent heme synthase"
                     /protein_id="WP_150486908.1"
                     /transl_table=11
                     /translation="MSAPEKLPNAGKKAKDLNEVIRYTLWSVFKLRDVLPEDRTGYADE
                     VQELFDQLAAEDVTVRGTYDVSGLRADADLMIWWHAETSDALQEAYNLFRRTRLGRALE
                     PVWSNMALHRPAEFNKSHIPAFLADETPRNYVSVYPFVRSYDWYLLPDEDRRRMLADHG
                     KMARGFPDVRANTVPAFSLGDYEWMLAFEADELHRIVDLMRHLRGSEARLHVREEVPFY
                     TGRRKSVADLVAGLA"
     gene            complement(9455..10888)
                     /gene="hemG"
                     /locus_tag="CP967_RS05770"
                     /old_locus_tag="CP967_05805"
     CDS             complement(9455..10888)
                     /EC_number="1.3.3.4"
                     /GO_function="GO:0004729 - oxygen-dependent
                     protoporphyrinogen oxidase activity [Evidence IEA]"
                     /GO_process="GO:0006779 - porphyrin-containing compound
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="hemG"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015579252.1"
                     /locus_tag="CP967_RS05770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CP967_05805"
                     /product="protoporphyrinogen oxidase"
                     /protein_id="WP_150486909.1"
                     /sec_met_domain="DAO (E-value: 2.3e-10, bitscore: 39.1,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQRSLQRDTSRTGHVVVIGGGIAGLAAAHRLLAGGLGVTLLEATG
                     RLGGKLMTGEVAGVRVDLGAESMLARRPEAVELATAAGLGGRLQPPATATASVWTRDAL
                     RPMPKGHVMGVPGDPAALGGVLSPEGLARIAEERGLAPTAVGDDVAVGAYVAGRLGREV
                     VDRLVEPLLGGVYAGDAYRISMRAAVPQLFEAAKEGGSLLDGVLRIQERAAARQQTGPV
                     FQGVAGGIGTLPDAVADAVRRGGAEIRTSTPVLGLTRTRDGWDVRTDTGVIAADGVVLA
                     APAWSASTLLAAECPAASALLAAVEYASMALITMAFRRSDLAGTKALRDRSGFLVPPVD
                     GRTIKAATFSSNKWRWVADAAPDLFVLRTSVGRYGEEDHLHREDGELVDVSLGDLAEAT
                     GLAARPVDTVVTRWTGGLPQYPVGHLTRVARIREEVAKLPGLRVCGAVYDGVGIPACVA
                     SARRAADEITRDLDAASTA"
ORIGIN
        1 ctccaggctg ggctcgtcga cagtcaggga ttcggcgtgc aggccggcgg aggccagggt
       61 gagcagcgtc tcgccgtcgg ctccgggacg ggtgagccgg atacccaccg tgagcggggc
      121 ggcttcggcc acgtggagct gttcgcccct ggcggcgagc agctcacggg cccggccggc
      181 ggcggaggcg tcacagaaac gcagggtcag gacacggtcg ccggcctccc ccttgaggac
      241 gtgcggggcg gcggaggcga tgaggcgtcc ggcgcggagg atgccgacac ggtcgcagag
      301 ctggtccgcc tcctccaggt actgggtggt cagcaggacg gtgacgccgt ggcccgcggc
      361 cagggcgcgg atctcgtccc acaggccccg gcggctggcc gggtcgagtc ccgtggtggg
      421 ttcgtccagg aagaggacgt ccgggcgctg gaccagagcg acggcgaggt cgacccggcg
      481 gcgctggccc ccgctgagct tgcccaccgg ggtgtccgcg aacgcttggg agtcgaaggc
      541 ggtgagaagt tcggcgcagc gcacgcgggc ctgccgggag gtgagcgact ggagccgtcc
      601 ttgcaggcgc agcagttcgc gggcggacat gagggggtcg agggcggtgc cctggaggac
      661 gaccccggtg cggcggcgga ccgccccggg gtcgcgcgtg atgtcggccc cggcgacctg
      721 ggcgctgccc cgggaggggc ggagcatcgt ggtgagcatc cggacggtgg tgctcttgcc
      781 cgaaccgttg gggccgagca gcccgtagac ctccccgggg ttcacttcca gatcgagccg
      841 gtccaccgcg gtgcgatcgg cgaagtcccg gcccagcccg agggcacgga tggacggagt
      901 ggcggtgtta ctcataccta aaacctacct atcgataggt aggttttgca agaatctctc
      961 ttccgggact ccatccgccg aaaagccggg gtcaacggtg ccgcaggcac ggcaccggca
     1021 ggaagaggtg cccggcgccc gcgcctgccc gccggggagc cggccggcac cggtaccggc
     1081 cgggcgttcg cggccgtccg cgggacgggt gcgcgtcacg tggtgccgta cccccgcttc
     1141 ccgggcggct gtcacaagga cgcggcgccg agggcacggc gctgaggacg cggcgccgag
     1201 ggcgccggcc ccggcggggt ggcggtggcg gggcccggcc ggtcagccgg agcaggccgt
     1261 gcggccggcc tcctgccacg cgcagaccgg gcacagggtg gcgcccttcg ccgactcggg
     1321 gtactcggtc ggctcccggc acagcacgca ctccgcgaac ggcccctcca cgggtccggg
     1381 tacgggcggt cgctcgggtg tggcgcagta ggcgtcgtcc atgtgcacga gcgtactcac
     1441 cgtcccgcgg gcgtactcgc tgtccgcagg cgtactcact cgcgcacggc ggtgagccgc
     1501 gccgtgaacc aggccaccgc cacggccagg agcatcgccg ctcccgaggc cgccaggggc
     1561 aggcgcacgg tgccgtcctg tgatccggag accaggtccg tcacggcgga gcgcgcgggc
     1621 gaaccgccgg ccacgagggc gagcagggtg ccgagcacgg tggcggcgag cgaccgtcca
     1681 cggcggtgca ggaccggacg ggcgcagagc gccccgatgg cggtgcccac cagtgcgcag
     1741 gaggccgtgg cgagcagccc ggcgagcgcg gcggacggga gcgggatgcc ggtggtgcgg
     1801 tcgttgccga ccggcgcgcc ggtcagcagg acgagcccgg tggccgcgac gcccagcgcc
     1861 agggtgcagc cgagggcggt gagcagggcg gccagatggg cccggcccgg tcccgcggcg
     1921 gccgcggtga cgtcccggga ggcgggcggc tcctgggtca cgcagagacg ggccagccag
     1981 gccccggcgg gcagcagggc ggcggccgcg tatccgaggg agtccagcag cggctgcccg
     2041 gcctggatgc cgatcccggc gaaggccgcg tacaggagga cgggcgcgag ccatcgctgt
     2101 gagcgggcga gcagggcggc ctggcagcgc agcagggggc cgagccggcg gccgggtgcc
     2161 cgggggacac cggcgggccg tggggcaccc ggccgtacgg gcggggccgg ggcggccgct
     2221 tcggtgtgcc ccctccggcc gccgtccggc ccggccgggc ccgcggccgt cgccgtgctc
     2281 tcgtcaggcg ccgggggccc gtcggacgtc cgtgccgctt ccggtgccgg ctccggggtg
     2341 agccgggtga tgtgccaggg ctcgcccgag gtcagcaggg tgcgcagcag tcggtccgag
     2401 tgtgccgtgg cgaccgtgag gaggacccgg ccgggggtgt ccgggtcccg ttggcaggcc
     2461 ggtgcgccgg gcagccgggg cggaagcgtc gcgccgggcg gggccgtcgc ctcgatccgg
     2521 acccgggagg cccccgcggc cccggcaggc cctacggtcc cggcggaagc ggtcggcccg
     2581 gtggtcccgg caggccctac ggccccggcg gaagcggccg gtacggctgt gagccggccg
     2641 ccgcccagca ggtacacggc gtcgaccgag cccgccagac ggcgtggatc gtggtcgacg
     2701 aagaccacgg tggctccggc ggcgacccgt tccccgacgg cccggtcgag ttcctcgcgg
     2761 gccgccgcgt ccagcccggt ccacgcctcg tccaggacca gcaggtccgg ttccgccatg
     2821 agcgcctgga cgacggcgac cttctggctg ctgcccttgg acagttccgc caagggcgtg
     2881 cgggcgtact cggccgcgtc gaacctggtc agccaccgtt cggcccgccg ggccgcctcc
     2941 gcggtgccca gaccgtgcac cctgcccagg tggaccaggt agccggccgc ggtgaacggc
     3001 agggcggccg ggaagcgttc ggggacgtac gccgtgcgcg ggcgcccctc ggcccgcccc
     3061 tcggtcggcg cgtcgatacc ggcgagcagc cggagcaggg tggacttccc ggtgccgttg
     3121 gcgccctgga gccgtatcag ggtgccgcgc ggcagcacca ggtcggcccc gcgcaccacc
     3181 caggcgcccc gaaggccgta acggcggccg gccccgcgca ggttcagctc gacgacgcct
     3241 tctcctgctt gagttcgctc ggccgtacga tcacgaagcc ctcgccctgg agcatcagct
     3301 ggaccgcctc gccggaacca ccgcgcacca tggacccgaa gctctgcgag cggtgcagcg
     3361 aggtgttcag ctgggcactc cagccgacga ccgcgtccgt gtcgacgtac accggctgct
     3421 gggcggtgac cgggatgacg atggggtggc cgtcacagat caggcccagc ttcccgtaac
     3481 cgctgaagac gctgttgaag agcccgccgc cggccatccc ggcgcccttg accgtcttga
     3541 tctcgtagga gaggccggcg tcgaagcaga ggacgttgcg gccgttgacg gtcaggacgt
     3601 cgccctgctc catctccacg atgaagcagt tcgccgcctc gtgggcgaac cacgcctcgc
     3661 cctgtccccg gaccgccatg agcggcagcc cctccccggt gaccgcgcgc ttgagcatgc
     3721 cgccgatgcc ctggcccttg cgctcgaact ggaggttgcc gcggaaggcg atcatcgagc
     3781 cctggcgggc gtgcatctcg ccgttgacgg cgtacttgat ggacttggcg ttctgcaggg
     3841 tcatcccggg ggcggtggcc tgctcggcca ggtgctcgct ggaaaagagg tcgctcttca
     3901 tccgggcatc ctcacccgga gcaccgcctt ccgccaagag gctcctcccg ctcgccggaa
     3961 ggggcctccg ccggaaggga ccgctccgcc ggaaggcgcc tttgcaggaa gggccccgcc
     4021 ggcaggggcc tccccgccgc ccggtgtgct gcccggttcc cgcccgggag ggggacacgg
     4081 cggcctggca gactggagcc cgtgagcagc gacgacgttc ccgaacccct tcccaccgct
     4141 tccgcggaca gtcccttccg ggtggagccg gccccccgcg acgaggcacc gcagttcgtg
     4201 cttccgctgg tggtgcgtct ggagaagacc gatcccccgg cgcgtaccga cgccctgcgg
     4261 acggcggcgc gcgcggtgct cacgatcctg tcggacgagc ggtctctcgg ggacggcgag
     4321 tgggccgagg ccgtgcggga ctggcaggac gcccggatcc gcaaggtggt gcggcgggcg
     4381 cgcggggcgg agtggcgcaa ggcgtccgcg ctgccgggca tcacggtcac cggcgagcac
     4441 gccgaggtgc gggtgttccc gccggtgccg ctggacggct ggcccaagga gctggccaag
     4501 ctccaggtgt ccgggaccga actggacgac ccggagcccc cgccggtgcc ggacgggtcg
     4561 aagcccgtgc tgtggctcaa ccccgggctg ggcatgtccg cgggcaagac gatggcccag
     4621 gccgggcacg gcgcgcagct ggcgtggtgg gggctgtcgg acaccgagcg cgaggcgtgg
     4681 cgcgcggccg ggttccccct cgacgtggcc gccccggacg aggtccgctg gcgtgaactc
     4741 accgggagcg ggctgccggt ggtacgggac gccggcttca ccgagatcga gccgggttcc
     4801 tgcacggtcg tcgcggacca ccccgcgctg cgccgctgag aggaaggcgt tccgcgggcg
     4861 ggcccggcgg ctcgccggac gccgcaccga gggcgggccc ggccccggaa cctcaaatca
     4921 tgctctgaac gtccccgttc acgggttcgg cgctccggca cggggccatg acccctgcac
     4981 aaggcatgga gggggacgtc atggggctgg gaatcggaat cggctggcgc ccggagatcg
     5041 cggacgccgt cgaggagctg ccggggatcg actgggtcga ggccgtcgcg gagaacctct
     5101 gcgacgacca cctccccggt ccgctcgcac ggctgcggga gcgcggggtc accgtcgtcc
     5161 cgcacggggt gtcgctgggc ctgggcgggg ccgggcgccc cgaccccggc cgtctcgccg
     5221 cgctcgccgc gcgggccacg ctgctcggtg ctccgctggt gacggaacac atcgcgttcg
     5281 tacgggccgg agggccgctc accgcttctc ccggactgga ggcgggtcat ctgctgcccg
     5341 tcccccgtac ctgggacgcg ctggacgtgc tgtgcgagaa cgtccggatc gcccaggacg
     5401 cgctgcccgt gccgctcgcg ctggagaaca tcgcggcgct ggtctcctgg ccgggcgagg
     5461 agctgaccga ggggcagttc ctcgccgagc tggtcgaacg caccggggta cggctgctga
     5521 tcgacgtggc caatctgcac accaaccacg tcaaccgggg cgaggacccc gtggcggccc
     5581 tcgacgagct ccccgtggag gcgatcgcct acgtccatgt ggcgggcggg atcgagaagg
     5641 acggtgtctg gcacgacacc cacgcccacc cggtgacccg gccggtcctg gacgtgctgg
     5701 cggaactgcg ctcgcggacc gatccgccgg gtgtgctgct ggaacgggac gacgacttcc
     5761 cgcccgccgg ggagctggcc ggtgaactgg ccgcgatccg caccaccctc gcgaccgccc
     5821 cgcccgcgcc gccgcccgtg ccccgtgccc gggcgccgcg ccccgctccg gccgggggcg
     5881 cccgggaccg ggtcgcggtc gcccagaccg cgctgctgtc cgcgctggtc gcgggcgccc
     5941 cggcgccgga ggggttcgac cggcggcggc tcggggtgca gagccgcgca ctggccgcca
     6001 agcgcgccga cgtcgtcgcc aaggtcgcgc cggagctccc ggagatcctg ggtgaggggt
     6061 accgccccgc gttcctcgcc tacgccggga gccgtccgca gaccgggggt taccggcgcg
     6121 acgcgctgga cttcgcggaa cacctgctga tcgcgggggc cccggccgac ggtgcggccc
     6181 gggacatgct gaccgcgtgg tggcgggacc gggcgtcgcc ccgcccgccg cgccgcgccg
     6241 cccggctcct ccgggcggcg ggcggcacac gcgtggtgcg ggccgctcgc ggtgttctcg
     6301 gcgggcggtg ggcgggatga ccgtgctgag cgctctcgcc gtcctgctga ccgccgtggt
     6361 ggcggtgctc tgcgtatgcg tactgcgtcc gtcccgcggg ccggccgggc ggtccgcgga
     6421 cgcctcggag gtccacgacg tcttcgaggc cgccttcctg agcgggggtc cggcccggac
     6481 ggtggacacc gcgctcaccg cgctgtacgc ggacggccgg ctggagatcg gcggccccgg
     6541 catcgtggcc gtacgccgtg ccgaggcgcg cgacgcggtg gagcgtgccg tcctgcggga
     6601 actggccgcc gcgccgagcg gcgccctgga cgccctgcgg acggcggtga tgcggcatcc
     6661 ggcggtgcag gaggtcggtg acggcctcgc ggcccggggg ctgctggccg caccggggga
     6721 cgaccgcggc cggcggaccc tggcacgggt gctggcggcc gggtcgggcg tcgccctccc
     6781 ggtgagtatc gtcctgacgg tcctggagta cctcctgctc accgacttcg acgacatgcc
     6841 gttcccgttc gccgccaagg tgctgcccgc gatcatggcc gggatcgtcg tcggtctgat
     6901 cggcgccccg tcggccggat cacggatcac cccggccggc cgccgggccg ccgcccggta
     6961 ccggaacgct cgtgcccagg aggacgaccc cgtcctcctg gtggccaccc ggggaccggc
     7021 cgcactgccg tacacggagc tgcgggagcg gttgtcggcc gccgcccgga cctcccggcg
     7081 gcatccctcc ccgctcctgg ccaccggcgg tccgtccgac gggggcgtgc cgccgccggt
     7141 gtggtgcgcg gggacggatc ccggccacga gggctgcggt gcgggcggtg acccggggac
     7201 gggctcctcg tgcggttccg gaggcggcga cggcggcggg tcgagctgcg ggagcggatc
     7261 gagctgcggc ggcgggtcga gctgcggggg cggcgggggg tgcggcagca gctcctgacg
     7321 ggctccggct cctgcggagc cccggcccgg gcaccggcac cggcaccggc accggagcgt
     7381 cccgatccag ccactgatga ccgactacga ccactttttg tccacatcac gaacaaggta
     7441 tggcgcttct gtgcccttct cgcatagaaa tcggccatgc tctgggttct cttcctcctg
     7501 gtcgcatggg gcgcggcagc cgtctcctgc atccggctct gtcttgtcac cgcgaacgcc
     7561 gcgccacggc cgggcgatgc cgccgatggc ccgccgccgc gtgaactgag cctttacgag
     7621 acggcgttcc tggccggcgg cccccatcgg gtcgccgatc tggcactggt ctcgatgcat
     7681 ctgcggcggg gactgctgct ggcccacacc ggctgggcga cggtcgtcga cccggagggc
     7741 cgggacgagg tggagcgcac cgtgatccgg gcgatcggcc cgcaggggca gtcgcggata
     7801 gcgccgatac gggcggcggc ggccgccgcc gacaccgtgc gggccctggc cgaccggctc
     7861 gtggcggccg gcctcgccgt gccgcacggg acgcggacca ctctggagtc ggcggcgcgg
     7921 ggggtgcggg gagcagcggt gctggtggtg gtgctggccg tggcgaccgt gctgatgccg
     7981 ggtcaggaga ccggggacac gggcccggtg gtggcgtggt tcgggctgcc gctggtgctg
     8041 acgctggggt gcctggccat cgcccgggtg gagagccatc cgtacagtcc gtgggcctcg
     8101 ccgtccggac agcggtggct ggactcgctg cccgcccccg cgcacggggc cgaccgcgac
     8161 gtgctggcgg cggtggccgt gcggggagcg gcggccgtac cggacccggg gctgcgggcc
     8221 gctctgctcg gcagcgcaca cggttcccgt accggggtct gagggacgac ggctggtgag
     8281 gcggcgaggc gcggtaccgg ctgccgcggc ccggccggag cgcccggctt cgccggaccg
     8341 tgcggccgcg gtgtgcggcc cccggcacgg cgggcctgac acggggtcag cgggtccgcc
     8401 gtaccggggg gccgttcggc ccgggacaca catcggccgt acccggcacg ggcggcggcc
     8461 cgcggggagg aatggctgac tcccccgcgg gtcaccgcac atcgccggcc ggagccgatg
     8521 tgctcccgga accggacccg gtgtcgctgg aacgacgggc ggcgtcacac acgccgttgc
     8581 ccgccaactg atcttccggg tccgggcggc cggtacacgc tggctgtgcg ggtccggcca
     8641 ccaggtcttc tgtacgcgcc ggttacgcga gccctgccac caggtccgcg accgacttcc
     8701 tgcgccccgt gtagaacggg acctcctcac gcacgtgcag ccgcgcctcg gagccgcgca
     8761 gatgacgcat caggtcgacg atgcggtgca gctcgtccgc ctcgaaggcc agcatccact
     8821 cgtagtcgcc gagcgagaac gcggggacgg tgttggcgcg gacgtccggg aagccccggg
     8881 ccatcttgcc gtggtccgcg agcatacgac ggcggtcctc gtccggcagc aggtaccagt
     8941 cgtaactgcg tacgaagggg tagacgctga cgtagttccg cggggtctcg tcggcgagga
     9001 aggccgggat gtgcgacttg ttgaactcgg cgggccggtg cagggccatg ttcgaccaga
     9061 ccggttccag ggcccggccg agccgggtgc gccggaagag gttgtacgcc tcctggagcg
     9121 cgtccgaggt ctctgcgtgc caccagatca tcaggtcggc gtcggcccgc agaccggaga
     9181 cgtcgtaggt gccgcggacg gtgacgtcct cggcggcgag ctggtcgaac agctcctgga
     9241 cctcgtcggc gtagccggtc cggtcctcgg gaagcacatc gcgcagtttg aagaccgacc
     9301 acagcgtgta gcggatgacc tcgttgaggt ccttggcctt cttaccggcg ttcggaagct
     9361 tttctggcgc actcatacgg ctattgtccc gcctcgctcg aatcgccctg aacccgggtc
     9421 gtcctcccgg ccgccgggcc gttctccccg gtgatcacgc ggtggacgcg gcgtcgaggt
     9481 cccgggtgat ctcgtccgcg gcgcgccggg cgctggcgac gcaggcgggg atgccgaccc
     9541 cgtcgtacac cgctccgcag acccgcagcc ccggcagttt cgcgacctcc tcgcggatcc
     9601 gggcgaccct ggtcaggtgg cccaccgggt actgcggcag accgccggtc caccgggtga
     9661 ccacggtgtc caccggccgt gcggccagcc cggtcgcctc cgcgaggtcc ccgagcgaca
     9721 cgtcgacgag ttcgccgtcc tcccggtgca gatggtcctc ctcgccgtac cggccgaccg
     9781 aggtacgcag cacgaagagg tcgggagcgg cgtccgcgac ccaccgccac ttgttgctgg
     9841 agaaggtcgc cgccttgatg gtgcgcccgt cgacgggggg tacgaggaaa ccggagcggt
     9901 cccgcagcgc ctttgtgccg gcgaggtcgg agcgccggaa ggccatggtg atcagcgcca
     9961 tcgaggcgta ctccacggcg gccagcaggg cggacgcggc cgggcactcg gcggccagca
    10021 gggtggaggc cgaccaggcg ggcgccgcca gcacgacccc gtccgcggcg atcaccccgg
    10081 tgtcggtgcg cacgtcccag ccgtcccggg tccgggtcag gccgaggacg ggggtggagg
    10141 tgcggatctc ggcgccgccc cggcgtacgg cgtcggccac cgcgtccggg agggtgccga
    10201 tcccgccggc gaccccctgg aagaccggac cggtctgctg ccgggccgcc gcccgttcct
    10261 ggatgcggag caccccgtcg aggagcgagc cgccctcctt cgccgcctcg aagagctgcg
    10321 gcacggcggc ccgcatcgag atccggtagg cgtcgcccgc gtacaccccg ccgagcagcg
    10381 gctccaccag ccggtcgacc acctcgcggc cgagccggcc ggccacgtag gcaccgaccg
    10441 cgacgtcgtc gccgacggcg gtcggggcga ggccgcgctc ctcggcgatc ctggccagcc
    10501 cctcgggcga gagcaccccg ccgagcgccg ccgggtcccc cggtacgccc atgacgtggc
    10561 ccttgggcat cgggcgcagg gcgtcacggg tccagaccga ggcggtggcg gtggcgggcg
    10621 gctggaggcg cccgccgagc ccggccgcgg tggccagctc gaccgcctcg gggcggcgcg
    10681 ccagcatcga ctcggcgccc aggtcgaccc gcacgcccgc gacctcaccg gtcatcagct
    10741 tgccgccgag ccgcccggtc gcctccagga gggtgacccc gagcccgccg gccaggagcc
    10801 ggtgggcggc ggcgagtccg gcgatcccgc cgccgatgac gacgacatgg cccgtacgcg
    10861 aggtgtcgcg ctgaagagaa cgctgcatgg gtccactctc tcaaacccgt aacgagtccc
    10921 gaacgtgacc gcttcgaaac cgctcaccgg caacccgctc gcgggccccc acgtcgaaag
    10981 ggcaccaacg gcaacagtcc tggggggaca tgtcatgcac ctcgaccggc acagcggcac
    11041 ccgtccgtcc gcgcatcccg tacgccgccg cttccgcgcg ccggcggcgg ccgcgctcct
    11101 cgtcctgctg ctcggcaccg gagcgtgcgg agcggccgac agctcgtccg acagcgacaa
    11161 gggggtggcc gccgccgcag acgcgaaggg cccggcgccc gaagcggagg gggctcccgg
    11221 cgcggagggc gcgggccggg cggagggtgc cgggaaggac ggcacctcct cgtcggagtc
    11281 cggacccggt acggcggtgg ccgtccacgt cgtccgtacg
//
