LOCUS       NZ_RDBM01000035        11293 bp    DNA     linear   CON 01-JAN-2025
DEFINITION  Streptomyces sp. gb1(2016) Scaffold_35, whole genome shotgun
            sequence.
ACCESSION   NZ_RDBM01000035
VERSION     NZ_RDBM01000035.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. gb1(2016)
  ORGANISM  Streptomyces sp. gb1(2016)
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 2333361)
  AUTHORS   Hariharan,J., Choudoir,M.J., Diebold,P., Panke-Buisse,K.,
            Campbell,A.N. and Buckley,D.H.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-OCT-2018) Soil and Crop Sciences, Cornell University,
            306 Tower Road, Ithaca, NY 14850, USA
REFERENCE   2  (bases 1 to 2333361)
  AUTHORS   Hariharan,J., Choudoir,M.J., Diebold,P., Panke-Buisse,K.,
            Campbell,A.N. and Buckley,D.H.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-OCT-2018) Soil and Crop Sciences, Cornell University,
            306 Tower Road, Ithaca, NY 14850, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2018
            Assembly Method                   :: A5+MeDuSa v. JUNE-2018
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 66x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_008042065.1-RS_2025_01_01
            Annotation Date                   :: 01/01/2025 02:23:01
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,414
            CDSs (total)                      :: 7,333
            Genes (coding)                    :: 6,887
            CDSs (with protein)               :: 6,887
            Genes (RNA)                       :: 81
            rRNAs                             :: 6, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 447
            CDSs (without protein)            :: 446
            Pseudo Genes (ambiguous residues) :: 0 of 447
            Pseudo Genes (frameshifted)       :: 94 of 447
            Pseudo Genes (incomplete)         :: 395 of 447
            Pseudo Genes (internal stop)      :: 7 of 447
            Pseudo Genes (multiple problems)  :: 48 of 447
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:17:57
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1905379
            Orig. end                         :: 1916672
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            RDBM01000035.1.
            Annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (released 2013). Information about the Pipeline can be
            found here: https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..11293
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="6"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11293
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11293
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6293](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..6293)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    complement(532..547)
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 22.24"
                     /tool="antismash"
     gene            596..2083
                     /gene="hemG"
                     /locus_tag="EAO74_RS18935"
                     /old_locus_tag="EAO74_18955"
     CDS             596..2083
                     /EC_number="1.3.3.4"
                     /GO_function="GO:0004729 - oxygen-dependent
                     protoporphyrinogen oxidase activity [Evidence IEA]"
                     /GO_process="GO:0006779 - porphyrin-containing compound
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="hemG"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015612176.1"
                     /locus_tag="EAO74_RS18935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EAO74_18955"
                     /product="protoporphyrinogen oxidase"
                     /protein_id="WP_147984166.1"
                     /sec_met_domain="DAO (E-value: 3e-12, bitscore: 43.7,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQRSLQRDTTRTGHAVVIGGGIAGLAAAHRLLASGLRVTVLEATE
                     RLGGKLMTGEIAGTQVDLGAESMLARRTEGVELATAAGLGDRLQPPATATASVWTRDAL
                     RPMPKGHVMGVPGDPSALSGVLSPEGLARIAEERDLTPTAVGDDVAVGSYVADRLGREV
                     VDRLVEPLLGGVYAGDAYRISMRAAVPQLFEAVKEGGPLLDGVQRIQERAAARQRTGPV
                     FQGLEGGIGTLPGAVADAVRAGGAEILVETPVLGLTRAAGGWDVRTDSGVIAADALVLA
                     TPAWSASTLLAAECPAASVELAAVEYASMALVTMAFRRSDVEGNEALQGRSGFLVPPVD
                     GRRIKAATFSSNKWRWVADAAPDLFVLRTSLGRYGEEEHLHREDSELVAASLGDLADAA
                     GLTARPVDTQVTRWIGGLPQYPVGHLTRVARIREEVAKLPGLRVCGAVYDGVGIPACIA
                     SARRAADEIVHDLTGAGAGEIDNTPTRVRGTGSEAGQ"
     gene            2088..2801
                     /gene="hemQ"
                     /locus_tag="EAO74_RS18940"
                     /old_locus_tag="EAO74_18960"
     CDS             2088..2801
                     /EC_number="1.3.98.5"
                     /codon_start=1
                     /gene="hemQ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003965515.1"
                     /locus_tag="EAO74_RS18940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EAO74_18960"
                     /product="hydrogen peroxide-dependent heme synthase"
                     /protein_id="WP_099174898.1"
                     /transl_table=11
                     /translation="MSAPEKLPNAGKKAKDLNEVIRYTLWSVFRLKDVLPVDRAGYADE
                     VQELFDQLGAKDITVRGTYDVSGLRADADLMIWWHAETSDELQEAYNLFRRTKLGRALE
                     PVWSNMALHRPAEFNKSHVPAFLADETPRDYISVYPFVRSYDWYLLPDEDRRRMLADHG
                     KMARGYPDVRANTVASFSLGDYEWVLAFEADELYRIVDLMRHLRASEARLHVREEVPFY
                     TGRRKSVAELVTGLA"
     gene            complement(3085..3861)
                     /locus_tag="EAO74_RS18945"
                     /old_locus_tag="EAO74_18965"
     CDS             complement(3085..3861)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014153334.1"
                     /locus_tag="EAO74_RS18945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EAO74_18965"
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_147984167.1"
                     /transl_table=11
                     /translation="MLWVLLLLVAWGAAAVSCIRLCLVTAGAAPLPSGAARAPVSPELN
                     LYETAFLAGGPQRVADLALVSMHLRRRLLLARTGWATVVDPEGRDEVERTVIRAIGPEG
                     QSRIAPIRAAAAAADAVRSLADRLVAAGLAVPHGARTDLESAARAVRGAAVLVVVLAAT
                     AMLMPGQETGYAGPVAAWFGLPLVLTLGCLAIARVENHPYSPWASPSGQRWLDSLPAPV
                     RGADRDLLAAVAVRGVGAVEDPDLRAALLSGARTAG"
     gene            complement(3980..4993)
                     /locus_tag="EAO74_RS18950"
                     /old_locus_tag="EAO74_18970"
     CDS             complement(3980..4993)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014153333.1"
                     /locus_tag="EAO74_RS18950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EAO74_18970"
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_124275366.1"
                     /transl_table=11
                     /translation="MNALALLLTLAVAVACTLLTVATQRARLRGDDTAAYVHDLSEAAF
                     LSGGPARVVDTALTRMHADGRLAVGGPGIVAVQRDEARDAVERAVLQELAGAPSGALHT
                     LREAVMRHPAVQEIGDGLAARGLLVAPGESRTRRSWGLVLGIWCILGFPGAIVVTVVQY
                     ATLDAYADLPFPFVVKVLPAIVAGSVVGLVTAASARTRLTRSGRRAADGYRAANAHLTD
                     PAHLVATRGLSALPDPELQAQLVAAARQRPAGRRSSTSTTSAATAAVLTPVVWCAGASP
                     GGGSCGGSSGGGGDSGSGSACSSGSSCGSSGSSCGGGSSCSSGSSCGGGSSCGSSS"
     gene            complement(5001..6293)
                     /locus_tag="EAO74_RS18955"
                     /old_locus_tag="EAO74_18975"
     CDS             complement(5001..6293)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014153332.1"
                     /locus_tag="EAO74_RS18955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EAO74_18975"
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_147984168.1"
                     /sec_met_domain="DUF692 (E-value: 1.8e-92, bitscore: 306.3,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLGIGIGWRPEIADAVEALPGIDWVEAVAENLCADHLPDSLVRL
                     RERGVTVVPHGVSLGLGGADRPDPGRLAGLAARAELLGTPLVTEHIAFVRAGGPLTASP
                     VLEAGHLLPVPRTWDALEALCENVRIAQDSLPVPLALENIAALISWPGEELTEGQFLAE
                     LVERTGVRLLIDVANLHTNHVNRGEDPATALDELPVEAIAYVHVAGGVEKDGVWHDTHA
                     HPVTRPVLDVLAELRSRVDPPGVLLERDDDFPPAGELAGELTAIRTTLAAAAPASGASR
                     NRAARPPEPAARPAGARDRTAVAQTALLSALVAGTPAPDGFDHRRLRVQSRALAAKRAD
                     VVAKVAPELPGILGDGYRPAFLAYARNRPMSAGYRRDALDFAERLLIQGRPADDAARRR
                     LTRWWQERAAARPPRRGARLVHAARTALLGK"
     misc_feature    6523..6536
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: strong, score: 24.25"
                     /tool="antismash"
     gene            6609..7958
                     /locus_tag="EAO74_RS18960"
                     /old_locus_tag="EAO74_18980"
     CDS             6609..7958
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004921391.1"
                     /locus_tag="EAO74_RS18960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EAO74_18980"
                     /product="family 43 glycosylhydrolase"
                     /protein_id="WP_147984169.1"
                     /transl_table=11
                     /translation="MTGTENRPPLGRRSLLTRAAGVGAAAALPVAAAPAQASAAPAAPA
                     RAGAKRRYPANWPDPEPYGRADIRQDLWPREDNSFVLPLELRPRDKERGVVWMRDTYVN
                     CFVVDGRPLYVATGTTRVPGLEAAGPWNDGIFVWVARSLKGPWKLADTTGIRPGAEKGK
                     VWSPEFTDENRPGRTVVAPWQEYWHDEQFGKRGQAWAPELHRFRGKWYIVACMGDHSRK
                     VGSFMLVSEGGVEGPYRLVEGNLEKPFGESFIGGPSFIEPGAYHHIDGSLYSEGRDAWL
                     VLHNNLYAKFRDDMEDIVTPVDLPLFRQTPYTPEPYLEGAYVFKHGGRYFLLHAAWDRT
                     SIDADGTARQGYDPAGTGRVQYQYDAVAAVSAHFEGPYSERWTVGVGAGHNNFFEDADG
                     DLWATFFRNPNFGHWSNPSRLPDAAVPGVVRVEWTGPKGNRLYVRRRDAD"
     gene            complement(7965..8717)
                     /locus_tag="EAO74_RS18965"
                     /old_locus_tag="EAO74_18985"
     CDS             complement(7965..8717)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014153331.1"
                     /locus_tag="EAO74_RS18965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EAO74_18985"
                     /product="DUF4142 domain-containing protein"
                     /protein_id="WP_187281894.1"
                     /transl_table=11
                     /translation="MRRINGTALIIAALVATLGALAFPVWSYADRSGTGEANLNASSVA
                     TQWGPLSATDRDFLVKVRLAGLWELPAGQQAIERAPSEGVKLAGDHLVVGHTDLDRRAR
                     DVAAKLGVELPNQPTEQQQGWLRELTAASGQEYEQKFANLLRAAHGKVFALIAQVRHTT
                     RNSLIRQLASDANQTVLDHITMLERTGFVDFDGLAREAAGASTASPSGPPMPSGGDVPQ
                     VPVPVTPSGDQSFTSRPVPPTMDPLPQP"
     gene            complement(8876..9640)
                     /locus_tag="EAO74_RS18970"
                     /old_locus_tag="EAO74_18990"
     CDS             complement(8876..9640)
                     /GO_function="GO:0004045 - aminoacyl-tRNA hydrolase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003997025.1"
                     /locus_tag="EAO74_RS18970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EAO74_18990"
                     /product="peptidyl-tRNA hydrolase"
                     /protein_id="WP_124275370.1"
                     /transl_table=11
                     /translation="MSTESIPEPLPASPQAPAGSPFRTEPTARDEAPQFVLPLVVHLEK
                     TDPPARNDALVTAARAVLTILSDPRSLGEDEGGAEGEWAQVMRDWQDARIRKVVRRARG
                     AEWRKASALPGITVTGEHAEVRVFPPVPLDGWPKELAKLQVSGTDLDDPEAPPAPDPSG
                     PVLWMNPDVAMSAGKAMAQAGHGAQLAWWELSETERKAWREAGFPLSVATPDAARWREL
                     TASGLPVVRDAGFTEVAPGSCTVVADHPALRR"
     gene            9715..10392
                     /locus_tag="EAO74_RS18975"
                     /old_locus_tag="EAO74_18995"
     CDS             9715..10392
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014153329.1"
                     /locus_tag="EAO74_RS18975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EAO74_18995"
                     /product="AIM24 family protein"
                     /protein_id="WP_124275371.1"
                     /transl_table=11
                     /translation="MKSDLFSSEHMAQQATAPGMTLQNAKSIKYAVNGEMHARQGSMIA
                     FRGDLRFERKGQGIGGMLKRAVTGEGLALMAVTGRGEAWFAHEAANCFIVEMEQGDVLT
                     INGRNVLCFDATLSYEIKTVKGAGMTGGGLFNSVFSGYGKLGLICEGHPIVIPVTPQQP
                     VYVDTDAVVGWSAQLSTSLHRSQSFGSMVRGGSGEAVQLKLEGEGFVIVRPSELKPEKP
                     SAH"
ORIGIN
        1 ccgacccggt gaggccgcgc agcacctcgt cgtaccgggc ctgcggcacg cgcagcacga
       61 gacgggacat gtcgtgggtg tcgtcgaccc gttccgtggt ctcgtccgcc acgagtccgc
      121 cggcgtcctc cgcggtgctc cgggccgccg cgaccgcctt cggcacgctc ccgacctcga
      181 tggccagggt ggccgtgcga atgacgtgga ccgcgaccgc ggagcccggg tcgggcgccg
      241 aggacgcgcc ggcggccggc ttcggcgccg cctccccggc tccggcgccg ggtgccgggc
      301 ccgccttgct gtcggccgcc gacctgaacc cctccccgcc gctgtcggag gcaccgccgc
      361 acgcaccggt ggccaggagc accacgagaa gtccggcggc cgccggtacg cgtgagcggc
      421 ggcgggtgcg agcgggtgga tgactgtccg tgtgccggtc gaaatgcatg agcgtccccc
      481 cagggccgtt gtcgatggtg ccggttcgac gtacggggcc cgtgtgcggg tttcccgcca
      541 ggggtttcga agcggtcacg ttcaggactc gggacgggtt tgagagagtg gacccatgca
      601 gcgttctctt cagcgcgaca ccacacgtac gggccacgcc gtcgtcatcg gcggcggcat
      661 cgccggactc gccgccgcgc accggctgtt ggcctccggc ctccgggtca ccgtcctgga
      721 ggcgaccgag cggctcggcg gcaagctgat gaccggcgag atcgcgggca cccaggtcga
      781 cctcggtgcc gagtcgatgc tcgcgcgccg gaccgaaggg gtcgagctgg ccactgcggc
      841 cgggctcggc gaccggctcc agccgcccgc caccgccacc gcctcggtct ggacccgcga
      901 cgccctgcgt cccatgccca agggccatgt gatgggcgta ccgggcgatc cgtcggcgct
      961 cagcggggtg ctctcgcccg agggcctggc caggatcgcc gaggagcgcg acctcacccc
     1021 gaccgccgtc ggcgacgacg tcgcggtcgg cagttacgtc gccgaccggc tcggccgcga
     1081 ggtcgtcgac cggctcgtgg agccgctgct cggcggggtg tacgccgggg acgcctacag
     1141 gatctcgatg cgcgccgccg tgccccagct cttcgaggcc gtgaaggagg gcggcccgct
     1201 cctcgacggc gtccagcgca tccaggagag ggccgcggcc cggcagcgga ccggcccggt
     1261 cttccagggc ctggaggggg gcatcggcac cctgccgggc gccgtggccg acgccgtacg
     1321 ggccgggggc gccgagatcc tcgtggagac ccccgtgctc ggcctgaccc gcgccgccgg
     1381 gggctgggac gtacgcaccg acagcggggt gatcgccgcc gacgccctcg tcctggccac
     1441 ccccgcctgg tccgcgtcga cgctgctcgc cgccgagtgc ccggccgcct cggtcgagct
     1501 ggccgccgtc gagtacgcct cgatggccct ggtcaccatg gccttccggc gctccgacgt
     1561 cgaggggaac gaggcgctcc aggggcgttc cggcttcctc gtaccacccg tcgacggccg
     1621 caggatcaag gccgccacct tctccagcaa caagtggcgg tgggtcgccg acgcggcccc
     1681 cgacctcttc gtgctgcgca cctccctcgg ccgctacggc gaggaggagc acctgcaccg
     1741 tgaggactcc gagctcgtcg ccgcgtccct gggcgacctc gccgacgcgg ccggactgac
     1801 ggcccggccc gtggacacgc aggtcacccg gtggatcggc gggctgcccc agtacccggt
     1861 cggccacctc acccgggtcg cgcggatccg cgaggaggtc gccaagctgc cgggtctgcg
     1921 ggtctgcgga gcggtgtacg acggcgtcgg gatccccgcc tgcatcgcga gcgcgcgccg
     1981 cgccgcggac gagatcgtcc acgacctgac gggcgcgggc gcgggggaga tcgacaacac
     2041 gccgacccgg gttcggggca ccgggagcga ggcgggacaa tagccgtatg agtgcgccag
     2101 aaaagcttcc gaacgcaggc aagaaggcca aggacctcaa cgaggtcatc cgctacaccc
     2161 tgtggtccgt cttcaggctg aaggacgtcc tgcccgtgga ccgcgccggt tacgccgacg
     2221 aggtccagga gctgttcgac cagctcgggg ccaaggacat cacggtccgt ggcacctacg
     2281 acgtgtccgg tctccgggcc gacgccgatc tgatgatctg gtggcacgcc gagacgtccg
     2341 acgagctcca ggaggcgtac aacctcttcc ggcgcaccaa gctgggccgc gcactcgagc
     2401 cggtctggtc gaacatggcg ctgcaccgcc ccgccgagtt caacaagtcg cacgtgccgg
     2461 ccttcctggc cgacgagacc ccgcgcgact acatcagcgt gtaccccttc gtgcgcagct
     2521 acgactggta cctgctgccc gacgaggacc gccgccgcat gctcgcggac cacggcaaga
     2581 tggcccgcgg ttaccccgac gtgcgggcca acaccgtggc ctccttctcg ctgggggact
     2641 acgagtgggt gctggccttc gaggccgacg agctgtaccg catcgtcgac ctcatgcgtc
     2701 acctgcgcgc ctccgaggca cggctccacg tccgtgaaga ggtgccgttc tacaccggac
     2761 gcaggaagtc cgtcgcagaa ttggtgaccg gactcgcata gccagcgttt ccggtcatcc
     2821 cgacccggaa gatcagttgg cgggcaacgg cgcgtgtgac gccgcccgtc gttccagcga
     2881 caccgggtcc cggtgccggg tgcacatcgg ccgacggccg gcgaactgtc gtggcctgcg
     2941 gaggagtcag ccattcctct ccgcgggccg ccgctcctcg ccggtcaggc cggtgtgtcc
     3001 cgggccgcac aactggatag cgcagcacgg agggccgccc cgncggggcg gccctccgtg
     3061 ctgcgcggcc tccggtccgg cgggtcagcc ggccgtgcgc gccccgctca gcagggccgc
     3121 tctcaggtcc gggtcctcca cggctcccac gccccgcacc gccaccgccg ccagcagatc
     3181 gcggtccgca ccgcgcaccg gtgccggcag cgagtccagc cagcgctgcc ccgaaggaga
     3241 ggcccacggg ctgtacgggt ggttctccac ccgtgcgatg gccaggcagc ccagcgtcag
     3301 gacgagcggc agcccgaacc aggcggccac cgggcccgcg tagcccgtct cctgaccggg
     3361 catcagcatg gcggtcgccg ccaggaccac caccagcacc gccgcgcccc gtacggcacg
     3421 ggccgccgac tccaggtccg tacgggcccc gtggggtacg gcgagccccg cggccaccag
     3481 gcggtcggcg agggagcgta cggcgtcggc agccgccgca gcggcccgta tcggggctat
     3541 ccgggactgt ccctccgggc cgatcgcgcg gatcacggtg cgctcgacct cgtcccggcc
     3601 ctccgggtcg accaccgtcg cccagccggt gcgggccagc agcagccggc gccgcagatg
     3661 catggagacc agcgccagat cggccacccg ctgcgggccg ccggccagga acgccgtctc
     3721 gtacaggttg agttcggggg agaccggtgc tcgcgcggcg ccggacggca ggggagccgc
     3781 acccgcggtg acgaggcaga gccggatgca ggagacggcg gccgcgcccc acgcgaccag
     3841 aagaagcagg acccagagca tggccgagtt ctatgcgaaa ccggcaaggg agcgccatgc
     3901 cgtgttcacc atatggacca agatcggtca cggacggtca ctggtggctg aatccatatg
     3961 cctgccgtcc cgcgcgctct caggaactgc tgccgcagct ggagccgccg ccgcaactgg
     4021 agccgctgct gcagctcgac ccgccgccac agctggagcc gctgctgccg cagctcgacc
     4081 ccgagctgca cgcggacccg gagcccgagt cgccgccccc gccgctggat ccgccgcagc
     4141 tcccgccgcc gggactcgcc ccggcgcacc acaccaccgg cgtgagcact gccgccgtgg
     4201 cggccgaggt ggtggacgtc gaggagcggc gccctgcggg ccgttgccgg gcggcggcca
     4261 ccaactgcgc ctggagctcc gggtcgggaa gcgcggacag cccccgggtg gccaccaggt
     4321 gggcggggtc ggtcagatgg gcgttggccg cccggtagcc gtcggcggcc ctgcgccccg
     4381 acctggtgag ccgcgtccgg gcggacgcgg cggtgaccag gccgaccacc gagccggcca
     4441 cgatcgcggg cagcaccttc accacgaagg ggaacggcag gtccgcgtac gcgtcgagcg
     4501 tggcgtactg cacgaccgtc accacgatgg cgcccgggaa ccccaggatg caccagatac
     4561 ccagcacgag cccccaggag cgccgggtcc ggctctcgcc cggcgcgacg agcagcccgc
     4621 gggcggcgag cccgtcaccg atctcctgca ccgcgggatg gcgcatcacc gcctcccgca
     4681 gggtgtgcag ggctccgctc ggggcgcctg ccagctcctg gagcacggcg cgctccacgg
     4741 cgtcacgggc ctcgtcccgc tggaccgcga cgatgccggg accgccgacg gccagccgcc
     4801 cgtccgcgtg catacgggtc agcgcggtgt ccacgacccg ggccggtcca ccgctgagaa
     4861 aggccgcctc ggagaggtcg tgcacatacg cggcggtgtc gtcgccccgc agccgggcgc
     4921 gctgcgtcgc gacggtcagg agcgtgcagg ccacggccac ggccagtgtc agcagaaggg
     4981 cgagagcgtt catcgcgggg tcactttccg agaagggcgg tacgggcggc gtggaccagg
     5041 cgggcacctc ggcgcggcgg tcgcgccgcc gcgcgctcct gccaccagcg ggtcagcctc
     5101 cgccgggcgg cgtcgtcggc cgggcggccc tggatgagca gccgctcggc gaagtccagg
     5161 gcgtcgcggc ggtaaccggc ggacatcggc cggttcctgg cgtacgcgag gaaggccggg
     5221 cggtagccgt cgccgaggat cccgggcagc tcgggcgcca ccttggcgac gacatcggcc
     5281 cgcttcgccg ccagggcgcg gctctgcacc cgcaggcgcc ggtggtcgaa gccgtccggc
     5341 gcgggtgtgc cggccacgag cgcggagagc agcgcggtct gcgccacggc cgtccggtcg
     5401 cgggccccgg ccggacgcgc ggccggctcc gggggccggg ccgcacggtt ccgggaagca
     5461 ccggaggcgg gggccgcggc ggccagggtg gtgcggatcg cggtcagttc accggccagc
     5521 tccccggccg gcgggaagtc gtcgtcgcgc tccagcagga cgcccggcgg atccacccgg
     5581 gagcggagct cggccagcac gtccaggacc ggacgtgtca ccgggtgtgc gtgcgtgtcg
     5641 tgccagacgc cgtccttctc gacgccgccc gccacatgga cgtacgcgat ggcctccacc
     5701 ggcagttcgt cgagtgcggt cgcggggtcc tcgccgcggt tgacgtggtt ggtgtgcaga
     5761 ttggcgacgt cgatcagcag ccgtacgccg gtgcgctcga ccagctccgc gaggaactgt
     5821 ccctcggtca gctcctcgcc gggccaggag atcagggcgg cgatgttctc cagggccagc
     5881 ggcacgggca gcgagtcctg cgcgatccgc acgttctcgc acagcgcctc cagggcgtcc
     5941 caggtgcggg gcaccggcag caggtggccc gcctccagga ccggcgaggc ggtgagcggc
     6001 cctccggcgc gtacgaacgc gatgtgctcg gtcaccaggg gcgtgcccag cagttcggcc
     6061 cgtgcggcca gacccgcgag gcggccggga tccggccggt cggcgccgcc caggccgagg
     6121 gagaccccgt gcgggacgac ggtgaccccg cgctcccgga ggcgcacgag ggagtcgggg
     6181 agatggtccg cgcagaggtt ctccgcgacc gcctcgaccc agtcgatccc cggcagagcc
     6241 tcgacggcgt ccgcgatctc aggccgccat ccgataccga tccccagctt catggtgtcc
     6301 cctccccgtg ccgtgcactg gtcatggccc cgccgcgcgc cggtgaaccc ggaaaggggg
     6361 acgttcagag ctgaatttga ggttcccgga ccggccccaa atgcaccgtt acccgatcgt
     6421 gatgctccgt acgggcccgt cggcaccccg ccgacctgcg gaaacgcgga ccgtcaccga
     6481 tatgccgacg agccggacac tccggattaa ttccatggtc cgttgacgga gatcaacagg
     6541 cgttcgcatg ctcgtcgaca tgccgggagc acgccgtccc ggacgaacga acggaggacg
     6601 tgaccgacat gaccggcacc gagaacaggc cgcccctggg ccgaaggtcc ctgctgaccc
     6661 gtgccgccgg agtgggcgcc gccgccgcac tccccgtcgc cgccgcgccg gcgcaggcct
     6721 cggcggcccc ggccgccccc gccagggccg gggcgaagcg gcggtacccg gcgaactggc
     6781 ccgaccccga gccctacggc cgcgccgaca tccggcagga cctgtggccc cgggaggaca
     6841 actccttcgt cctcccgctg gagctgcgcc cgcgtgacaa ggagcgcggc gtggtgtgga
     6901 tgcgggacac ctacgtcaac tgcttcgtcg tggacggccg tccgctctac gtcgccaccg
     6961 gcaccacccg agtgcccggc ctcgaagcgg ccggcccctg gaacgacggc atcttcgtct
     7021 gggtggcgcg ttccctcaag ggcccctgga aactggccga cacgaccggg atccggcccg
     7081 gagcggagaa gggcaaggtc tggtcgcccg agttcaccga cgagaaccgg cccggacgca
     7141 ccgtcgtcgc cccgtggcag gagtactggc acgacgagca gttcggcaag cgcggccagg
     7201 cctgggcccc ggagctgcac cgcttccgcg ggaagtggta catcgtcgcg tgcatgggcg
     7261 accactcccg gaaggtcggc tcgttcatgc tcgtgagcga gggcggtgtc gagggcccgt
     7321 accggctcgt cgaggggaac ctggagaagc ccttcgggga gtcgttcatc ggcggaccga
     7381 gcttcatcga gcccggcgcc taccaccaca tcgacggcag cctctacagc gagggccgcg
     7441 acgcctggct ggtgctgcac aacaacctct acgcgaagtt ccgcgacgac atggaggaca
     7501 tcgtcacgcc ggtggacctc ccgctgttcc gccagacccc ctacacgccc gagccgtacc
     7561 tcgaaggcgc gtacgtcttc aagcacgggg gcaggtactt cctcctccac gccgcctggg
     7621 accggacgtc gatcgacgcc gacggcaccg cacgccaggg ctacgacccg gccggcaccg
     7681 gccgggtgca gtaccagtac gacgcggtcg ccgccgtctc cgcccacttc gaggggccgt
     7741 actccgagcg ctggaccgtc ggcgtcggcg ccgggcacaa caacttcttc gaggacgccg
     7801 acggcgacct ctgggcgacg ttcttccgca acccgaactt cggccactgg tccaacccgt
     7861 cccgcctccc cgacgcggcc gtgcccggcg tcgtacgggt ggagtggaca ggaccgaagg
     7921 gcaaccgcct gtacgtccgg cgccgggacg ccgactgacg gtccctacgg ctgaggcagc
     7981 ggatccatcg tcggtggcac cgggcgggac gtgaacgact ggtcgccgct cggggtcacc
     8041 ggcaccggga cctgcgggac atcgcccccc gacggcatgg gcggacccga ggggctggcc
     8101 gtcgaggcgc cggccgcctc ccgcgccagg ccgtcgaagt cgacgaagcc cgtgcgctcc
     8161 agcatcgtga tgtggtccag caccgtctgg ttggcgtcgg aggccagctg ccggatcagc
     8221 gagttacggg tggtgtgcct gacctgcgcg atcagcgcga acaccttgcc gtgcgcggcg
     8281 cgcaggaggt tggcgaactt ctgctcgtac tcctggccgc tggccgcggt gagttccctg
     8341 agccagccct gctgctgctc ggtcggctgg ttcgggagct ccacgccgag cttggccgcc
     8401 acgtcgcggg cccgccggtc cagatccgtg tgaccgacca ccaagtgatc gcccgcgagt
     8461 ttcaccccct cgctgggcgc ccgctcgatg gcctgctgcc cggcgggcag ttcccacagc
     8521 cccgccagac gcaccttgac caggaagtcc cggtcggtcg cggagagcgg gccccactgg
     8581 gtggccacgc tggacgcgtt cagattggcc tcgccggtcc cggagcggtc ggcgtacgac
     8641 cacacgggga aggcgagcgc gccgagtgtg gcgaccagcg ccgcgatgat gagggccgtt
     8701 ccgttgatgc gtcgcagcaa gatgtctccc gggcaggtgc gtgacaacgt cgaatcaacc
     8761 gccaactgac tcgtcgctca acctacttgg cggtaatgcc ggtgcggcag taccgggagg
     8821 tacgtatatc ggcgcaggaa tgttcagcct gccgggcttc cggccccgcg accgttcagc
     8881 ggcgcagggc cgggtggtcg gcgacgaccg tgcaggaccc cggggcgacc tcggtgaagc
     8941 cggcgtcccg caccaccggc agtccgctcg cggtcagttc gcgccagcgg gcggcgtccg
     9001 gggtggcgac ggagagcggg aaccccgcct cgcgccacgc cttgcgctcc gtctccgaca
     9061 gctcccacca ggcgagctgc gcgccgtgcc cggcctgcgc catcgccttg cccgccgaca
     9121 tggcgacgtc cggattcatc cacagcaccg ggccggacgg atccggtgcg ggcggggcct
     9181 ccgggtcgtc caggtcggtc cccgacacct ggagcttggc cagctccttc ggccagccgt
     9241 ccaggggaac cggcgggaag acccgcacct ccgcgtgctc acccgtgacc gtgatccccg
     9301 gcagcgcgga cgccttgcgc cactccgcgc cgcgcgcccg ccgcaccacc ttgcggatcc
     9361 gggcgtcctg ccagtcgcgc atgacctgag cccactcgcc ctccgccccg ccctcgtcct
     9421 caccgagcga gcgcgggtcc gagaggatcg tgagcaccgc gcgggccgcg gtcaccaggg
     9481 cgtcgttgcg cgccggcggg tcggtcttct ccaggtgcac caccagcggc agcacgaact
     9541 gcggggcctc gtcgcgggcc gtcggttccg tacggaaggg actgccggca ggggcctgcg
     9601 gggaggcggg aaggggctcg ggaatgctct cggtgctcac acccaccagt ctgccaggcc
     9661 gccgcgacca cccgttcttg gcggaacgaa gggctccggg cgaggatgca cgccatgaag
     9721 agcgacctct tttccagcga gcacatggcc cagcaggcca ccgcccccgg catgaccctg
     9781 cagaacgcca aatccatcaa gtacgccgtc aacggtgaga tgcacgcacg ccagggatcg
     9841 atgatcgcct tccggggcga tctccggttc gagcgcaagg gccagggcat aggcggcatg
     9901 ctcaagcgcg ccgtgaccgg cgaggggctg gccctgatgg cggtcaccgg ccggggcgag
     9961 gcgtggttcg cccacgaggc ggcgaactgc ttcatcgtcg agatggagca gggtgacgtc
    10021 ctgaccatca acggccgcaa cgtcctctgt ttcgacgcga ccctctccta cgagatcaag
    10081 accgtgaagg gcgccggcat gaccggtggc ggcctcttca acagcgtctt cagcggatac
    10141 gggaagctcg gcctgatctg cgagggccac cccatcgtga tccccgtgac cccgcagcag
    10201 ccggtgtacg tcgacacgga cgcggtcgtc ggctggagcg cccagctctc cacctcgctg
    10261 caccgctcgc agagcttcgg ctcgatggtg cgcggcggat cgggcgaggc ggtccagctg
    10321 aagctggagg gcgaggggtt cgtgatcgta cggccgagtg agctcaagcc ggagaagccg
    10381 tcggcccatt gatgctgcga ggagtgggcc gccggtacgg cctgcgcggc ccctgggtgc
    10441 tgcgcgggct cgacctggac ctgcccgcgc acaccctggt ccggatcgag ggagccaacg
    10501 gagtcggcaa gtcgacactc ctgcggctgc tcgccggcat cgacgcgccg accgaggggc
    10561 gcatgacggg ccggccgcgc acggcgtacg tccccgaacg cttccccgcc gcgctgccgt
    10621 tcaccgcggc cggatacctc acccacatgg ggcgcgtcca cgggctcccg gcagccgagg
    10681 ccgccgcacg cggccaggag tggctggcgc gcttcggggc cgccggatac gcccgtacac
    10741 ccctcgccga gctctccaag ggcaccagcc agaaggtcgc cgtcgcccag gcgctcctcg
    10801 ccgggccgga cctcctcgtc ctggacgagg cctggaccgg gctggacacc gaggcccgcg
    10861 gcgcagtgga ccgggccgtc gcggagcggg ccgccggcgg cgccacggtg gtgttcgtcg
    10921 accacgaccc ggggcggctc gccggtgcgg tgggcctcgc gtaccggctg gaggaccgca
    10981 ccctcacccc ggtgccggcc tcgcccggtg acgacgggcc gcgcgtgcgg atcgaggcga
    11041 cgggccggcc gtccgccgcc ctcccgccgg aactgccggg ggccccggca gtggaacggg
    11101 acgccgggaa tccggccgcg atccggctca cgacctccgc ggcgtactcg gaccccctgc
    11161 tccacgccct gctcacggcc cgccctccgt ggcacatcac cgggctctcg cagctccccg
    11221 tcccggtccc ggcctcccgg cccgccgccg ccccgggtcg tggtcgacga acaccaccgt
    11281 ggcgccgccg gcg
//
