LOCUS       NZ_RDBM01000035        21071 bp    DNA     linear   CON 01-JAN-2025
DEFINITION  Streptomyces sp. gb1(2016) Scaffold_35, whole genome shotgun
            sequence.
ACCESSION   NZ_RDBM01000035
VERSION     NZ_RDBM01000035.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. gb1(2016)
  ORGANISM  Streptomyces sp. gb1(2016)
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 2333361)
  AUTHORS   Hariharan,J., Choudoir,M.J., Diebold,P., Panke-Buisse,K.,
            Campbell,A.N. and Buckley,D.H.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-OCT-2018) Soil and Crop Sciences, Cornell University,
            306 Tower Road, Ithaca, NY 14850, USA
REFERENCE   2  (bases 1 to 2333361)
  AUTHORS   Hariharan,J., Choudoir,M.J., Diebold,P., Panke-Buisse,K.,
            Campbell,A.N. and Buckley,D.H.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-OCT-2018) Soil and Crop Sciences, Cornell University,
            306 Tower Road, Ithaca, NY 14850, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2018
            Assembly Method                   :: A5+MeDuSa v. JUNE-2018
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 66x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_008042065.1-RS_2025_01_01
            Annotation Date                   :: 01/01/2025 02:23:01
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,414
            CDSs (total)                      :: 7,333
            Genes (coding)                    :: 6,887
            CDSs (with protein)               :: 6,887
            Genes (RNA)                       :: 81
            rRNAs                             :: 6, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 447
            CDSs (without protein)            :: 446
            Pseudo Genes (ambiguous residues) :: 0 of 447
            Pseudo Genes (frameshifted)       :: 94 of 447
            Pseudo Genes (incomplete)         :: 395 of 447
            Pseudo Genes (internal stop)      :: 7 of 447
            Pseudo Genes (multiple problems)  :: 48 of 447
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:17:57
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1479744
            Orig. end                         :: 1500815
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            RDBM01000035.1.
            Annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (released 2013). Information about the Pipeline can be
            found here: https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21071
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="4"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21071
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21071
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11071](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11071)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    1109..1124
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: medium, score: 24.01"
                     /tool="antismash"
     misc_feature    1113..1122
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.63"
                     /tool="antismash"
     gene            1265..2797
                     /gene="eccB"
                     /locus_tag="EAO74_RS17220"
                     /old_locus_tag="EAO74_17235"
     CDS             1265..2797
                     /GO_process="GO:0009306 - protein secretion [Evidence IEA]"
                     /codon_start=1
                     /gene="eccB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012378783.1"
                     /locus_tag="EAO74_RS17220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EAO74_17235"
                     /product="type VII secretion protein EccB"
                     /protein_id="WP_147984011.1"
                     /transl_table=11
                     /translation="MASRRDELNAYTFAKRRLVAQFLQPHPSGSEEGAPRPLRAVVPGA
                     IVGVVVLAVFGAWGMFKPVAPQKWDTPYENVIIASKSTTRYVVLKTDGKTQLHPVLNMS
                     SAKLLLAPDKGQVVNVSESVLDSGKIPHGATLGIPYAPDRLPDKSEAGAAKRWAVCERP
                     GEGGRAIQKAAFVFAEREKGKTEGANKLHGGELMYVEGPGPDRTRYIVDATGTAYSVTN
                     DELLLRTLVGQGRDPQRVSADWLDTLHKGDPVTFPAIEGNPGDPAGIPGELQTDDNRVG
                     MVLSAVSGTRTQQYVVLKGRVAPVSDFVAKLLLSSRDLVGLDQDGKAQDVSAGAFEPGE
                     AFGQEKKWPTSKPEPVNSASTESGSRNTVCNVLRSVSDKNGTSTLSTWVGTGFPATLPT
                     GSSSAYVTPGSGQLFRQFKGSSPESGPLFLVTDTGLRYAMQSNGDSVEDDSGIGESGTK
                     EEKAQAQQEAQQAQNHLGYKDVDPAPVPAAWSAFLPTGPRLSTGAARQPQGS"
     gene            2809..4053
                     /gene="mycP"
                     /locus_tag="EAO74_RS17225"
                     /old_locus_tag="EAO74_17240"
     CDS             2809..4053
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0009306 - protein secretion [Evidence IEA]"
                     /codon_start=1
                     /gene="mycP"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014153729.1"
                     /locus_tag="EAO74_RS17225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EAO74_17240"
                     /product="type VII secretion-associated serine protease
                     mycosin"
                     /protein_id="WP_147984012.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 1.6e-47, bitscore:
                     159.2, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTPSYRRRLLTASAATAVLLVSLPVLPAAADDSTQCTFPSKKYA
                     GRPWALQRVLMDELWEQSTGKGVRVAVIDTGVDVKNPQLTKAVDTGSGKNLLDKNIKDE
                     NGNKIERGKENGTTDVVGHGTKVAGIIAAREAKGTGFTGLAPDATIIPIQQNDAEGHGT
                     AETLADAINYAAGQGRANVINISQDTANAVKPTPLLEQAVNAALAKEIVIVASAGNDGL
                     GGNVKKTYPASYDGVLAVASSDRNNERAAFSQSGDFVGVAAPGVDMISTVPGGGHCSDN
                     GTSFSAPYVAGVAALIKAKHKDWTQEQIVAQIEQTAERSIAGHDHLVGWGVVDPVRALT
                     EDDKPIEKPVAHEGVSKGKAPVPAAIHLGETADERNARLATYVVVGGAVLVAAIAGAAV
                     TVRDRNRRQGRPGGV"
     gene            4201..4653
                     /locus_tag="EAO74_RS17230"
                     /old_locus_tag="EAO74_17245"
     CDS             4201..4653
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017947729.1"
                     /locus_tag="EAO74_RS17230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EAO74_17245"
                     /product="hypothetical protein"
                     /protein_id="WP_147984013.1"
                     /transl_table=11
                     /translation="MAKGKGDLQKGAGALEAFQKKVNALLADLESSPAGKSKVAAQTVS
                     RHAFSGQNACFAEADGLYTQYNRVHEALVTLSKSLGEQIEYLNLGVHAAAVGFDNVDDD
                     TRRRFYEIQAHMDAEREKAQAEKHAKPEQPRSDTNTGSAYDDLGDS"
     gene            4653..6365
                     /locus_tag="EAO74_RS17235"
                     /old_locus_tag="EAO74_17250"
     CDS             4653..6365
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015611837.1"
                     /locus_tag="EAO74_RS17235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EAO74_17250"
                     /product="hypothetical protein"
                     /protein_id="WP_147984014.1"
                     /transl_table=11
                     /translation="MSDDKQPELTPAEQQQEDKERVQGQLVVTDVTRQMQDVMEVFGFG
                     SGGSSGRTSFEGHELNAMIDLIENSNPEHLEEAGQALLKARTSMKEAAGELKGFIEGVE
                     WEGESGTAFRDWGRGLVAHAEKLGDFAEVAGTQITVAGTGLASVRNSLPPRDSRLVRKS
                     PEDIESPARIEENPEYAAALKVEKDRQEAINQANRLASYYAVSEETLAAQEPPRFEKKL
                     DVAMPRPQGHWLETEPSGSTSSGDSASSGSVDSGNVSHHAVAGSPGSSASTQGFETPVA
                     VAPVPERGVSTEIDSVATPSAPVTTPPTTPPAPTTGPAGPGGGQNLPLANGFVNPLTNS
                     SRGPQTPTAAPRAVGRAGGDTRTGSGPASNSRTTGPQVGRPSPMNGGTPSARGVTGPQS
                     PTAGRSGVTGGRPTSVGHAGTSGTSAPRAGRGGIVGGTPQRSAPGASGGVRGAPRGTVI
                     GTGGAARPGGSVGGAGQRGVVGNGSGNAPRSAGRGTPSANGVVGTPRGGPARPGAGAKG
                     FTAGGAGLVRGPAGRKDSRDEDQDEGTPRPDYLTEDRETWESGRRGVAPPVIE"
     gene            6391..7638
                     /locus_tag="EAO74_RS17240"
                     /old_locus_tag="EAO74_17255"
     CDS             6391..7638
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014153726.1"
                     /locus_tag="EAO74_RS17240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EAO74_17255"
                     /product="S8 family serine peptidase"
                     /protein_id="WP_147984015.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 6e-44, bitscore:
                     147.4, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAGMSQTRKRRMSLGMRGRVFGTVVLAGALSVGFAGTASADVDA
                     QSKQWYLTPMHAEEMWKSATGKGIKVAVIDTGVNPETPSLKGQVLRGFDATGASGDEFD
                     DYAGHGTTMAELIAGTGDGGGLKGLAPDTKIIPLRVAGADWETKESLNPLDTADAIRAA
                     ADSDAQIISMSFGNEFKLDQEIEAVKYAESKGKLFFSAVGNEGGEGNKPTYPAAYPEVV
                     GVAATDPQGKASEYSQHGDFVDIAAPGDGIPTWCDSNFQGYCESEGGTSQATAITSAAA
                     ALIWSAHPDWTANQVLNVLLDTAGRGDMEKGEVSNYVGHGIIRPAVNILKGTGDPGAPD
                     ISPLTNEKTAGSPASPAASASGSSQPENKEKAEDAAMAGSSTDDGSQLGLILGGVAVVL
                     VLGGGAFVLARRRRSA"
     gene            7717..8070
                     /locus_tag="EAO74_RS17245"
                     /old_locus_tag="EAO74_17260"
     CDS             7717..8070
                     /GO_component="GO:0005576 - extracellular region [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014153725.1"
                     /locus_tag="EAO74_RS17245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EAO74_17260"
                     /product="WXG100 family type VII secretion target"
                     /protein_id="WP_099177836.1"
                     /transl_table=11
                     /translation="MADQKLSDEMLLKLEGELTKRFDSVRGQLKTLQATIDSLEGAWKG
                     IGASAFNVKQADINVKMGNIATRLVNFQEAIKAARTISGNTEDEIRQALQGVDVVPGHS
                     GGSEAKTSAINAL"
     gene            8134..8433
                     /locus_tag="EAO74_RS17250"
                     /old_locus_tag="EAO74_17265"
     CDS             8134..8433
                     /GO_component="GO:0005576 - extracellular region [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014153724.1"
                     /locus_tag="EAO74_RS17250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EAO74_17265"
                     /product="WXG100 family type VII secretion target"
                     /protein_id="WP_099177837.1"
                     /transl_table=11
                     /translation="MPTNDGTMVVTYSSLEQAAGDIDRQSRQLQEDLAAIKRMVANVSE
                     LWVGEAKSAYDAAQAGWDRDATGIHTALSEISRKVRDAGTSYHAGDKRARANFE"
     gene            8861..9712
                     /locus_tag="EAO74_RS17255"
                     /old_locus_tag="EAO74_17270"
     CDS             8861..9712
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010468879.1"
                     /locus_tag="EAO74_RS17255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EAO74_17270"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_147984016.1"
                     /transl_table=11
                     /translation="MRAGEGAGDAANNEPELSDSLKTFGAVLKALRDEAHLTQEQFAPL
                     VQYSAAYIAKIEQGKRFPPRDLLERSEEVLGTTAARVLAAAARSLTRKVGLASWFRQWA
                     GIEEEAITLCAYECRAIPGLLQPEAYIRAIFERRLPPLSEEQIEHQVTARLERQQLLTD
                     RPNTAFSFIIEQALLERHMGGPDVLRQLLEYLLEQSMRRNVEIQVMPLRQYDHAGIDGL
                     MYLAETRQHEWVGYSEGQQSSILITSPNDVSAMLQRYGKLRSQALGREATVSLLEQMRG
                     EL"
     gene            9709..9900
                     /locus_tag="EAO74_RS17260"
                     /old_locus_tag="EAO74_17275"
     CDS             9709..9900
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016070.5"
                     /locus_tag="EAO74_RS17260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EAO74_17275"
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_129265784.1"
                     /transl_table=11
                     /translation="MSTREPVWLRSSYSGSSGDNCVEVAAHQATVLIRDSKCTQKRPLS
                     VSLAAWSAFTTLAAGSTV"
     gene            complement(10001..11071)
                     /locus_tag="EAO74_RS17265"
                     /old_locus_tag="EAO74_17280"
     CDS             complement(10001..11071)
                     /EC_number="4.2.3.166"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014153723.1"
                     /locus_tag="EAO74_RS17265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EAO74_17280"
                     /product="(+)-(1(10)E,4E,6S,7R)-germacradien-6-ol synthase"
                     /protein_id="WP_147984017.1"
                     /sec_met_domain="T1TS (E-value: 6.2e-74, bitscore: 246.9,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSPAPAPKIPQLWVPLPSGIHPSWREIDERSAAWLDRFGLYSDR
                     AQRERLTRISVGEITSRGAPAGRLGALQWTSDFLMWLFAFDDEFCDEGPVAASPDATLL
                     IITKLQRVVDVPWAAPADDNYSAALRELRLRLDGLTTPVQTARWAASFRAYLQGQIWMA
                     ANSAQGRIPTLSDHLAVRLDSSGVKIFSTLSEIIHGYDLPAADYERHDVRGFVEVFASI
                     IGWSNDLVSYHKERQRSQEGYGNIVDLIAYERKCTLEEAVSETAMMHTRAMALYLRLRD
                     QILSDAGPELRRWITDCDSWIRADYDWSLTTNRYVNPENPADLPAGSAASPFQEREADL
                     PLPIASIGWWWTLVKN"
     misc_feature    complement(10685..10687)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    11116..11133
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.93"
                     /tool="antismash"
     gene            complement(11385..11978)
                     /locus_tag="EAO74_RS17270"
                     /old_locus_tag="EAO74_17285"
     CDS             complement(11385..11978)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EAO74_RS17270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EAO74_17285"
                     /product="hypothetical protein"
                     /protein_id="WP_147984018.1"
                     /transl_table=11
                     /translation="MVVLLLVLAAGLVAMGCVRADQVRRWRRSLSPSAPEVPDSAFVVA
                     RVALFGMAGIGVFSAFQFMAVVADAEWSDDELSHAVGQATEELNGTSRFSDIYGEDSGF
                     DEEFATMIEDEVVENGGGGAPQSGVDAGAAPLNKPSGADYTVQAAGADAAFCVHVVRTR
                     SKGGDYEPPGIAGNPGTVTVPNYDFAVTSRKGEC"
     misc_feature    12047..12059
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.5"
                     /tool="antismash"
     gene            complement(12086..16054)
                     /gene="eccCa"
                     /locus_tag="EAO74_RS17275"
                     /old_locus_tag="EAO74_17290"
     CDS             complement(12086..16054)
                     /GO_process="GO:0009306 - protein secretion [Evidence IEA]"
                     /codon_start=1
                     /gene="eccCa"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006127993.1"
                     /locus_tag="EAO74_RS17275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EAO74_17290"
                     /product="type VII secretion protein EccCa"
                     /protein_id="WP_124274986.1"
                     /transl_table=11
                     /translation="MSQIVVKRPPRALPSEVPGEQVQLQPPPELPRGQQEGVMMQLLPM
                     LGMGGSVVFFFMTPNPIMRIMGMVMIASTIAMAISMIIRFRRGTQGQLADMRRDYLKYL
                     TQTRRAVLRTARQQRDAQFYLHPSPEQLWALVAEGSRVWERRVGDADFAHVRIGLGSQE
                     LATPLVAPDTAPVDELEPLTAGAMQQFLTTHSTLDGLPMAVSLRAFYHLTISGEAESAR
                     ATARAMVGALASLHSPEDLIIAVATGRDAAPRWEWTKWLPHVQVQGSIDGAGSRRLITT
                     SVAELEEMLAGRLDGRPRFQPGGQPLLDQPHVVVVLDGESVPATSALASAEGLQGVSVV
                     EIVTGQVNGARGGLSIVVDPHSLQLESGNGLVYDGLPDLLSHEAAEALARQLAPLHVAS
                     GGDDDEPLLANLEFTDLLNLGDAASVDVSRTWRPRSQAERLRVPIGVGEDGAPVMLDLK
                     EAAQEGMGPHGLCVGATGSGKSELLRTLVLGLAVTHTSETLNFVLADFKGGATFAGMAQ
                     MPHVAAVITNLADDLTLVDRMGDSISGELNRRQEMLRDAGNYANIHDYEKARAAGAPLQ
                     PIPSLVLVIDEFSELLTAKPDFIEMFVQIGRIGRSLGVHLLLASQRLEEGRLRGLETYL
                     SYRIGLRTFSAGESRAALGVPDAYHLPNVPGSGYLKYGTDEMVRFKAAYVSGVYRSGAQ
                     PVVSSGPLPVDRRPVVFTAAPVPVRYVQPTERPGVPEARKAEDDALADTVLDVIVRRLE
                     GRGASAHQVWLPPLDNPPSLDELLPGLSAVEGRGLTQPGFEGSGRLVVPLGVVDKPYEQ
                     RRDTLYRDFSGAAGHMQITGGPQSGKSTLLRTLIAGFALTHTPQEVQFYGLDFGGGGLA
                     SVSGLPHVGGIASRLDPERVRRTVSEVYGIMARREEYFRSAGIDSIATFRRLRARGDIS
                     VTDQPWGDVFLLIDGWGNFRTDYEALEAAAIDIAQRGLGYGIHLIVTASRSMEVRANLK
                     DHLMNRLELRLGDVMDSELDRKAAVNVPPGVPGRGLTPEKLHFMAAVPRIDGINSDSDL
                     SEATAAMNQEVARHWTAAPAPAVRLLPRELPVHDLPAGYARPERGIAFGIDENNLEPVF
                     LDFERDPFFLVFGESESGKSNLLRLLIKQLTERYEGNAAKFFVIDNRRALLDVTPATHL
                     AEYVPMSNNMEHHMDALYDLMKRRTPSPDVTAQELRDRSWWSGPDVFVVVDDYDLVSTS
                     SGNPLAKLTEMLPFSRDVGVRFIIARSTAGAGRALYEPFLQRILELGAQGLMLSGDPIE
                     GDILGNVRPRPMPPGRGVFVTRRRGNPLVQSGLMDGDR"
     gene            16301..17803
                     /gene="eccD"
                     /locus_tag="EAO74_RS17280"
                     /old_locus_tag="EAO74_17295"
     CDS             16301..17803
                     /GO_process="GO:0009306 - protein secretion [Evidence IEA]"
                     /codon_start=1
                     /gene="eccD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018512723.1"
                     /locus_tag="EAO74_RS17280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EAO74_17295"
                     /product="type VII secretion integral membrane protein
                     EccD"
                     /protein_id="WP_124276035.1"
                     /transl_table=11
                     /translation="MTAQTAATGSGRPGPGVPAGNGTGFCRVTVVAPDSRVDVALPEDI
                     PVADLYPEILRLSGQSPTQGAPVGYHLVRRDGTVLDSGRTLAGQRILDGELLSLRPFSE
                     SLPPAVFDDVSDAVASAVARDRTLWGDTLMRSAGLFGGSVLLVLLGFVLWTSDVRHDMH
                     GLPGILAAVAALLLLALACVRARVYDDRGSSIALGIGALTSAAVGGAGLLPLSTGQGVG
                     RLQFLLACAAVLVVSVILMIAAPEGDGTFVAFVFASAIGVLVTFIAIMTGMEPAETAAV
                     CAPLSVGLLGFLPGLSTRFARLPIGFEPPRTTTGDYGTSDPAPQGPVDADRIAAQARRG
                     HELLLGLVGGCALVAVGAAAVLGFSDSVWGQLLALATGAAMLMRAHLFRYTAQVGCALG
                     AGLAALVLLGLGLSLNPPAELFLDAFKGDTTGLDIRTIWLTAAVAGVAALITAIGLIVP
                     RKGVTPFWGRFLEVAEACVLLTLLPLCLAVFDVYHSIRALTS"
     gene            17981..18271
                     /gene="rpsO"
                     /locus_tag="EAO74_RS17285"
                     /old_locus_tag="EAO74_17300"
     CDS             17981..18271
                     /GO_component="GO:0005840 - ribosome [Evidence IEA]"
                     /GO_function="GO:0003735 - structural constituent of
                     ribosome [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /gene="rpsO"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006127995.1"
                     /locus_tag="EAO74_RS17285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EAO74_17300"
                     /product="30S ribosomal protein S15"
                     /protein_id="WP_003965855.1"
                     /transl_table=11
                     /translation="MPLDAATKKQIMSEFAQKEGDTGSPEVQVAMLSRRISDLTEHLKT
                     HKHDHHSRRGLLILVGQRRRLLQYLAKKDIQRFRALVDRLGIRRGAAGGAK"
     gene            18542..20755
                     /locus_tag="EAO74_RS17290"
                     /old_locus_tag="EAO74_17305"
     CDS             18542..20755
                     /EC_number="2.7.7.8"
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /GO_function="GO:0004654 - polyribonucleotide
                     nucleotidyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0006396 - RNA processing [Evidence IEA]"
                     /GO_process="GO:0006402 - mRNA catabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018512722.1"
                     /locus_tag="EAO74_RS17290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EAO74_17305"
                     /product="polyribonucleotide nucleotidyltransferase"
                     /protein_id="WP_099177844.1"
                     /transl_table=11
                     /translation="MENETHYAEAVIDNGTFGTRTIRFETGRLAKQAAGSAVAYLDDDT
                     MVLSATTASKRPKDNLDFFPLTVDVEERQYAAGKIPGSFFRREGRPSEDAILTCRLIDR
                     PLRPSFKKGLRNEIQIVETIMALNPDHLYDVVAINAASASTILAGLPFSGPIGATRVAL
                     IKGQWVAFPTHTELEDAVFDMVVAGRVLEDGDVAIMMVEAEATEKTIQLVKDGAEAPTE
                     EVVAAGLEASKPFIKALCKAQSDLAAKAAKPTGEFPVFLDYQDDVLEALTKAVSTELAK
                     ALTIAGKQEREAELDRIKDIAGEKLLPAFEGREKEISGAYRALTKKLVRERVIKDKVRI
                     DGRGVTDIRTLAAEVEAIPRVHGSALFERGETQILGVTTLNMLRMEQQLDTLSPVTRKR
                     YMHNYNFPPYSVGETGRVGSPKRREIGHGALAERAIVPVLPSREEFPYAIRQVSEALGS
                     NGSTSMGSVCASTMSLLNAGVPLKAAVAGIAMGLISQEIDGKTHYVALTDILGAEDAFG
                     DMDFKVAGTKQFVTALQLDTKLDGIPASVLAAALKQARDARLHILDVMNEAIDVPDEMS
                     PNAPRIITVKIPVDKIGEVIGPKGKMINQIQEDTGADITIEDDGTIYIGAQQGSQAEAA
                     RATINAIANPTMPEVGERYLGTVVKTTTFGAFVSLMPGKDGLLHISQIRKLAGGKRVEN
                     VEDVLGVGAKVQVEIAEIDSRGKLSLIPVIEGEEDEKKDDTDK"
ORIGIN
        1 gcggcgtcgc tccccggccc agctcgggcc agcggtcgac cgcgtacgtg gtgtgccagc
       61 ggtcgtcgca gcgccagacc cgcgtcgtct ccgtcgtccg ccgctgaggc gcggcatccg
      121 ggcgccccgc acgcgccgac aggatggggt tcgcgcacgc ggacgtcgcc acggcggagt
      181 tgagctcctc ctggtccagc accgaggccc ggaaacccgc gcccgtgatc cggctcgcca
      241 catggtccgc gacccgcacc agacagcgct gagcccctcc gatcccgcca ccgcgggcct
      301 ccacggcctc ccggcacagc tccggatcca gcttcaccgc cacccaggtc atccgcagcg
      361 cgggcgcccc ggtcctgtcc tggagcgggg cgtacgagag ccgggccacc gaccgctccg
      421 gcagatgcgg cgccggagcg ggccgcacct gctgcacgag ctgcgccgac tccagcacga
      481 tgtcgtccac cgcgagcgcg tcacccagca gggacagcgg cagcgcacgg gcgcccatgg
      541 cctgacggag cgactcaccg ctcgcctcga cccggacgac cgcggtcagg aacgtgccgt
      601 cccctagcat gccgaccgtg cggcgggcgc cgtcgacgta gatgtacggg gcgaaccccg
      661 gcacgttctc cgcgaccggg gccagctgcg gctccgtctc ggccgggggc gccgtcgcgg
      721 tccgccggcg gtggcgcagg gaggacacgg tcgacaacca gtcctggacg gcgcggcccc
      781 tgcggcgtac caccgcgagg aggatcagca gacaggcgat cacgcctgcg gggatcatcc
      841 aggcaccgcc gagcgcggcg cccaccacgg cgaccgccag ggccgcttcg acgagcacca
      901 tctgccgcag cgcgggtccg acgcggccgg tcctggagat cgaatggagc gtggtggccg
      961 cgggggtgtc cgcagagctg cggggggccg tgccgtcagg cccgttgctg cgttgccgcc
     1021 gggaaggggc gggcgttcgc cggtcggacc gcctcgtgcg ctcgcccgtc gctgcagcca
     1081 tcgccgcgtt gccccctcgt gtccgtattc accgtttttt tcacgggcgt tgatcgggcg
     1141 atcaccctac ctgagcggtg aatgccaagt gccaacaggc atagtagggg tcccggtcgg
     1201 cggcagcggt ccacggcggg tgtgggaacc tggtcgccca ctggggagaa ggggcagcgc
     1261 gcacatggca tcacggcggg acgaactcaa tgcctacacc ttcgcgaagc ggaggttggt
     1321 cgcacagttc ctgcagcccc acccgtcagg ctcggaggag ggcgcaccgc gccccctgcg
     1381 cgcggtggtc cccggagcga tcgtcggcgt cgtcgtcctg gcggtgttcg gagcctgggg
     1441 gatgttcaag cccgtggccc cccagaaatg ggacaccccg tacgagaacg tcatcatcgc
     1501 cagcaagtcc accacccgct acgtggtgtt gaagaccgac ggcaagacac agctccaccc
     1561 cgtcctgaac atgtccagcg ccaagctgct cctcgccccg gacaagggac aggtcgtcaa
     1621 cgtcagcgaa tcggtcctcg acagcggcaa gatcccgcac ggcgccaccc tcggcatccc
     1681 gtacgccccg gaccgcctgc ccgacaagtc cgaagccggc gccgcgaagc gctgggcggt
     1741 ctgcgagcgg cccggcgagg gcggcagggc catccagaag gcggcgttcg tcttcgcgga
     1801 gcgcgagaag gggaagaccg agggcgcgaa caagctgcac ggcggcgagc tgatgtacgt
     1861 cgagggcccc ggaccggaca ggacccgcta catcgtggac gccacgggca ccgcgtactc
     1921 ggtgacgaac gacgaactcc tgctgcgcac cctggtcggc cagggacgcg acccccagcg
     1981 ggtgtccgcg gactggctgg acaccctgca caagggggac ccggtcacct tcccggccat
     2041 cgagggcaat cccggtgacc ccgcggggat tccgggggag ctccagaccg acgacaacag
     2101 ggtgggcatg gttctctccg cggtctccgg caccaggaca cagcagtacg tggtcctgaa
     2161 gggccgcgtc gccccggtgt ccgacttcgt cgccaaactc ctcctcagca gccgcgacct
     2221 ggtcggcctc gaccaggacg gcaaggcgca ggacgtcagc gccggcgcgt tcgagcccgg
     2281 cgaggcgttc ggacaggaga agaagtggcc cacgagcaag ccggagcccg tcaactccgc
     2341 gagcaccgag agcggaagcc gtaacaccgt gtgcaacgtc ctgcgctcgg tctccgacaa
     2401 gaacggcacc agcaccctca gcacgtgggt cggcacgggc ttccccgcca cgctccccac
     2461 cggctccagc agcgcctacg tcacccccgg atccgggcag ctcttccgcc agttcaaggg
     2521 gtccagcccc gagtccggtc ccctcttcct ggtgaccgac accgggctgc gctacgcgat
     2581 gcagtccaac ggcgacagtg tcgaggacga ctccgggatc ggtgagtccg gcacgaagga
     2641 ggagaaggcg caggcccagc aggaagccca gcaggcgcag aaccacctcg ggtacaagga
     2701 cgtcgacccc gcgcccgtac ccgccgcctg gtccgccttc ctgccgacgg gcccccgact
     2761 gtcgaccggc gccgcccgcc agccgcaggg ttcgtgagga gcgatcacgt gaccacgccc
     2821 tcgtaccggc ggcggctgct gacagcctcg gccgccaccg ccgttctcct cgtgtcgctg
     2881 ccggtgctgc ccgcagccgc ggacgactcc acccagtgca ccttcccctc gaagaagtac
     2941 gccggccgcc cctgggcgct gcaacgcgtg ctgatggacg aactgtggga gcagtccacg
     3001 ggcaagggcg taagggtggc cgtcatcgac accggcgtcg acgtcaagaa cccccagctc
     3061 acgaaggccg tggacaccgg gagcggcaag aacctcctgg acaagaacat caaggacgag
     3121 aacggcaaca agatcgagcg cggcaaggag aacggcacca cggacgtggt cggccacggc
     3181 accaaggtcg ccggcatcat cgccgcgcga gaggccaagg gcaccggctt caccggtctc
     3241 gctcccgacg cgacgatcat cccgatccag cagaacgacg ccgagggcca cggcacggcg
     3301 gagaccctgg cggacgccat caactacgcg gccgggcagg ggagggcgaa tgtcatcaac
     3361 atctcccagg acacggccaa cgcggtgaag cccacgcccc tcctggagca ggcggtgaac
     3421 gcagccctgg ccaaggagat cgtgatcgtc gcctcggccg gcaacgacgg cctgggcgga
     3481 aacgtgaaga agacctaccc ggcgtcgtac gacggtgtcc tggccgtcgc ctcctcggac
     3541 cgcaacaacg aacgcgcggc cttctcccag tccggcgact tcgtgggcgt cgcggccccc
     3601 ggcgtggaca tgatctcgac ggtccccggc ggagggcact gctccgacaa cggcaccagc
     3661 ttctcggccc cgtacgtcgc cggggtcgcg gccctcatca aggccaagca caaggactgg
     3721 acgcaggagc aaatcgtcgc ccagatcgag cagacggcgg aacgctcgat cgcaggccac
     3781 gaccacctgg tcggctgggg tgtcgtcgac ccggtgcgcg ccctgaccga ggacgacaag
     3841 cccatcgaga aaccggtggc acacgaaggt gtgagcaagg gcaaggcgcc ggttccggcc
     3901 gccatccatc tgggcgaaac cgcggacgag cgcaacgcca ggctcgccac gtacgtcgtg
     3961 gtgggcggag cggtcctggt ggccgccatc gcgggtgcgg cggtgaccgt gcgggacagg
     4021 aatcggcggc agggacggcc cggcggagtg tgacgccgtg gaagtcacgt gatggacaag
     4081 acagttggtc ctgtcagtgc cattggctag agtgatgtga tggggtcagc gctgttcacg
     4141 cgggtgcgat agcaacgcga aacggactga gcaaacgggg aaacggggaa gggcagcaac
     4201 gtggccaagg gaaaaggaga tctccagaag ggcgcgggcg ccctggaggc tttccagaag
     4261 aaggtgaacg cgttgctggc agaccttgag agttcgccgg cgggtaagtc gaaggtggcg
     4321 gcacagacgg tgtcgcgtca tgcgttcagt ggccagaacg catgcttcgc ggaggccgac
     4381 gggctctaca cccagtacaa ccgcgtccac gaggcgctcg tcacgctctc gaagtcgctg
     4441 ggcgagcaga tcgagtacct gaacctgggc gtgcacgcgg cggcggtcgg cttcgacaac
     4501 gtggacgacg acacgcggcg ccggttctac gagatccagg cgcacatgga cgccgagcgc
     4561 gagaaggcac aggcggagaa gcacgccaag ccggagcagc cgcgctccga caccaacacc
     4621 ggctctgcct acgacgactt gggtgatagc tgatgagtga cgacaagcag ccggaactga
     4681 ctcctgcgga acagcagcag gaggacaagg aacgcgtcca agggcagctg gtcgtcaccg
     4741 acgtgacccg ccagatgcag gacgtgatgg aggtgttcgg cttcggcagc ggcggctcct
     4801 ccggccggac gtccttcgag ggccacgagc tcaacgcgat gatcgacctg atcgagaact
     4861 ccaatccgga gcacctcgaa gaggcgggcc aggcgcttct gaaggcacgg acatcgatga
     4921 aggaagcggc cggcgagctc aagggcttca tcgaaggtgt cgagtgggag ggcgagtccg
     4981 gaacagcctt ccgtgactgg ggcaggggcc tggtggccca cgccgagaag ctcggtgact
     5041 tcgccgaggt ggcgggtacc cagatcactg tcgcgggaac gggtctcgct tcggtccgca
     5101 actccctgcc gccccgggac agccgcctgg ttcgtaagtc tcccgaggac atcgagagcc
     5161 cggcgcggat cgaggagaac ccggagtacg cggcggcgct gaaggtcgag aaggaccgcc
     5221 aggaggccat caaccaggcg aaccggctgg cttcgtacta cgcggtgtcg gaggagacgc
     5281 tggcggcaca ggagccgccg cggttcgaga agaagcttga tgttgctatg ccgcggccgc
     5341 aggggcattg gctggaaact gagccgtcag gttccacgtc gtcaggagac tcagcgtcgt
     5401 cgggcagcgt ggattccggg aacgtgtcgc accacgcagt ggcaggcagc cccgggtcgt
     5461 cagcgagcac ccaaggattc gagacgcccg tcgcggtggc ccctgtcccg gaacgcggag
     5521 tttcaacaga gatcgacagc gtcgccactc cgtcggcacc ggtgaccacc ccacctacga
     5581 ctcctcctgc gccgaccacg ggccctgcgg gcccaggggg cggccagaat ctgcccctcg
     5641 cgaatggctt cgtgaacccg ttgacgaaca gttcacgggg gccccagaca cccacggccg
     5701 cgccccgagc cgtcggccgg gccggtggcg atactcggac aggtagcggc ccggcgtcca
     5761 acagccgcac taccggacct caggtggggc gcccctctcc catgaacgga ggaacaccct
     5821 ccgcacgtgg ggtcaccggt ccgcagtcgc cgactgccgg tcgatccggt gtcacgggtg
     5881 gcaggccgac atcggtaggt catgcgggta cgtccggaac ttccgccccg cgtgcaggcc
     5941 gaggcggcat cgtcgggggg acgccccagc gttcggcgcc cggggcgtcc ggaggcgtgc
     6001 gtggtgcccc acgcggcaca gtcatcggaa ccggcggagc ggcacggccg ggaggttcag
     6061 tcggcggggc cggacaacgc ggcgtcgtcg gcaatggaag cggtaacgcc cctcgttctg
     6121 cggggcgggg tacccccagt gccaacgggg ttgtcggcac gccccgtggt ggccccgcac
     6181 ggcccggggc gggcgcgaag ggcttcaccg caggcggtgc tggtctcgtg cgtggcccgg
     6241 cgggccggaa ggactccagg gacgaggacc aggacgaggg tacgccgcgt ccggactacc
     6301 tgaccgaaga cagagagacg tgggaatccg gacgtcgtgg agtcgcaccg ccggtgatcg
     6361 agtaggtaca gggaaggttc ggaagtcggg atgacagcag gaatgagcca gacccggaag
     6421 cgccgtatgt ctcttggaat gagagggcgt gtattcggca ccgtggtttt ggccggtgcg
     6481 ctgagcgtgg gatttgcggg gactgcatcc gccgatgtgg acgcgcagtc gaagcagtgg
     6541 tacctgacac ccatgcatgc cgaggagatg tggaagtcgg ccacaggcaa aggcatcaaa
     6601 gttgctgtca tcgacaccgg tgtcaaccct gaaacgcctt ccctgaaggg gcaggtactc
     6661 aggggtttcg atgccaccgg ggccagtggc gatgaattcg acgactacgc cggccacggc
     6721 accaccatgg ccgagttgat tgccgggacg ggggacggtg gagggctgaa aggcctcgcc
     6781 ccggacacga agatcatccc gttgagggtc gcgggcgccg attgggagac aaaggaatct
     6841 ttgaatcccc ttgatacggc agatgcgatt cgggctgctg ctgatagtga tgcgcagatc
     6901 atcagcatgt cgttcggtaa cgaattcaaa ctagatcagg aaattgaagc ggtaaaatac
     6961 gcggaaagta aagggaagct atttttttcc gctgtcggta atgagggagg cgaggggaat
     7021 aagcccactt atccggcagc atatccagaa gtcgtcggtg tagcggcaac ggacccgcaa
     7081 ggtaaagctt cagagtactc gcagcacggt gacttcgtag acattgcggc ccctggtgat
     7141 ggtattccaa cgtggtgtga ctcgaatttc cagggctact gcgagtcaga aggcggaacc
     7201 agtcaggcca ccgccatcac ctcggccgcc gccgccctga tctggtccgc ccacccggac
     7261 tggaccgcga accaggtcct caacgtcctc ctcgatacgg ctgggcgagg cgacatggaa
     7321 aagggcgagg tcagcaatta cgtcggccac ggcatcattc gcccggccgt caacatcctc
     7381 aagggcacag gagatccggg cgccccggac atcagtcctc tcaccaacga gaagaccgcc
     7441 ggctccccag cctcgcccgc cgcatccgca tcaggttcgt cacagcctga gaataaggag
     7501 aaggcggagg acgccgctat ggcaggctcc agcacggacg acggcagcca actgggcctg
     7561 atcctcggcg gagtggccgt ggtgctcgtc ctcggaggcg gcgctttcgt gctcgctcgc
     7621 aggcgccgtt ccgcctgatt gaccgtagtt ccttatacga acccccggcg gcgtaccgcc
     7681 ggaccgaaca agagcaccag gaaggaagcc agaactatgg cggatcagaa gctttcagat
     7741 gagatgctcc tcaagctgga aggcgagctc accaagcggt tcgattccgt gaggggccag
     7801 ctgaagacgc tgcaggcgac gatcgacagc ctggaaggtg cctggaaggg tatcggcgcc
     7861 agcgccttca acgtcaagca ggctgacatc aacgtgaaga tgggcaacat cgccacgcgt
     7921 ctcgtcaact tccaggaagc catcaaggcg gcccggacca tctccggcaa caccgaggac
     7981 gagatcaggc aggccctcca gggcgtcgat gtcgtccccg gccactcggg tggttccgag
     8041 gccaagacgt cagccatcaa cgctctctga gccctgccgt acccgtacca cgtacgggcc
     8101 atcacatcgc actagattga actggaggac cgtatgccga ccaacgacgg cacgatggtt
     8161 gtcacttact cgagcctgga gcaggccgcc ggtgacatcg accggcagag caggcagctt
     8221 caggaggacc ttgcggcgat caagcgcatg gttgccaacg tgtccgagct ctgggtgggc
     8281 gaggccaagt cggcgtacga cgccgcccag gccggctggg accgtgacgc cacggggatc
     8341 cacaccgctc tgtccgagat ctctcgcaag gtgcgcgacg ccggtacttc gtaccacgcg
     8401 ggcgacaagc gggcgcgggc caacttcgag taggtctcgc cagctgaaca actcagggtc
     8461 agggtgggca cgcacgggag gtgcccaccc tgacctttgt cgtggggccc acgcagccgg
     8521 tgtcgagtaa gtacacggaa ggtacggaag tcgggatgac agttagatga gccagccccg
     8581 gaagcgccgt gtgcctcttg gcgcgaaagg acacgtgttc ggagtccaat gaatggtgtc
     8641 cgaaagcgcc cgatgcctgc gtacagagcc caccccgggg gggtgattcg gacgtgaccg
     8701 caggtccact gggcccgtgc tgatacagaa tcccttgtac tggtcgaact gtgtactggg
     8761 cgggtagctg cccgtgaccg cagaggccgt ccgcgttgta ccgggcagca ccacggttgg
     8821 gtccggtgct gagcggacac ggaagagcgg gcggtgggcg atgcgggcag gcgaaggggc
     8881 cggggacgcg gccaacaacg agcctgagtt gtcggacagc ctcaagacgt tcggggcggt
     8941 gctgaaggcg ctacgggatg aagcccatct cacccaggag cagttcgcgc ctctggtgca
     9001 gtactcggcg gcgtacatcg ccaagatcga gcaggggaag cggttcccgc cgagggacct
     9061 gctggagcgc tcggaggagg tgttggggac gacggctgcg cgggtgctcg cggcggctgc
     9121 gcggagcctg acgcgaaagg ttgggctggc gtcgtggttc cggcagtggg cggggatcga
     9181 ggaggaggcg atcacgctgt gcgcgtacga gtgccgggcg atcccggggt tgttgcagcc
     9241 ggaggcgtat atccgggcga tcttcgaacg acggctaccg cccctgtccg aagagcagat
     9301 cgagcaccag gtgaccgccc ggctggagcg acagcaactc ctgaccgaca ggccgaacac
     9361 ggcattcagc ttcatcattg aacaggcact gctggaacgg cacatgggcg ggcccgacgt
     9421 ccttcgtcag ctcttggagt atctgcttga gcagagcatg cggcgtaacg tcgagatcca
     9481 ggtcatgccc ctgcgccagt acgaccacgc cggcatcgac ggcctgatgt acctggccga
     9541 gacccggcag cacgagtggg tgggctactc cgagggacag cagtcgagca ttctcatcac
     9601 gtcaccgaat gacgtgagcg ccatgctcca gcgctatggc aagctgcgct cgcaggccct
     9661 cggccgcgaa gccaccgtaa gcctgttgga gcagatgcga ggagaactat gagcacgaga
     9721 gagccggttt ggctcaggag cagctacagc ggcagctcgg gcgacaactg cgtcgaagtg
     9781 gcggcacacc aggcaaccgt tctcatccgg gactcgaaat gtacgcagaa gcgtccgctg
     9841 agcgtatccc tggctgcatg gtcggcgttc acgacgcttg cagccggctc aacggtgtaa
     9901 acggggacgc tggggcagcc tcctgaccta ctcctccgat acccccagct cgtccggcac
     9961 gccggccgtg ccggacgaaa cgatgacgaa cccgtggtga ctagttcttc accagcgtcc
    10021 accaccagcc gatgctggcg atcggcagag gcaggtccgc ctcccgttcc tggaaggggg
    10081 aagccgcgct gccggccggt aggtcggcgg ggttctcagg gtttacgtag cggttggtgg
    10141 tgagcgacca gtcgtagtcg gcgcggatcc aggagtcgca gtccgtgatc caccggcgga
    10201 gttcggggcc ggcgtcgctc aggatctggt cgcggaggcg gaggtagagg gccatggcgc
    10261 gggtgtgcat catggcggtc tcgctcaccg cttcttcgag ggtgcacttc cgctcgtacg
    10321 cgatcaggtc gacgatgttg ccgtagcctt cctggctgcg ttgccgttcc ttgtggtacg
    10381 agaccaggtc gttggaccag ccgatgatcg acgcgaagac ctcgacgaac ccgcggacgt
    10441 cgtggcgctc gtagtcggcc gcggggaggt cgtatccgtg gatgatctcg ctgagcgtcg
    10501 agaagatctt gactccggag gagtcgagcc ggaccgccag gtggtcggag agcgtgggga
    10561 tccgcccctg agcgctgttg gcggccatcc agatctggcc ctggaggtag gcacggaagc
    10621 tcgcggccca gcgtgcggtc tgcacgggcg tggtcaggcc gtcgagccgc agccgcaact
    10681 cacgtaacgc ggcgctgtaa ttgtcgtcgg cgggtgccgc ccaggggacg tcgacgacac
    10741 gctggagctt ggtgatgatg agtagggtcg cgtccgggga tgccgcgacc gggccctcgt
    10801 cgcagaactc gtcgtcgaag gcgaagagcc acatcaggaa gtccgaggtc cactgcaacg
    10861 ccccgaggcg tcctgcgggg gcgccgcggc tggttatctc gcccacggag atccgcgtca
    10921 gccgttcgcg ctgcgctcgg tcggagtaga ggccgaatcg gtcgagccag gcggccgagc
    10981 gttcgtcgat ctcacgccaa ctcgggtgga ttccggaggg aagcggaacc cacagctgag
    11041 ggatcttcgg cgctggagct ggggaggtca tgtaccgccc tttcgcatgt acttttcaat
    11101 gcctctgaga cccggaagtt agcaaggtgt agagggaacg ggtacagccc tttccagcct
    11161 gcttggctcg cggacgaccg tgcccctcac ccccggatcg ggcacctggc aacgccttcg
    11221 gcgcttgtga gaggtgcgaa aatggttgat cacgcatcgt ttgcggttga tcaccccggg
    11281 cacacacttg gcccgaaagt gcctcttgaa agttcaggat tcatcgattc ccgcgctgac
    11341 caccgagttc tgacccgccg aggaagcggc gaggaagtcg ggcgtcagca ttcgcccttg
    11401 cggctcgtca cagcgaagtc gtagttcggg acggtcacgg tgccaggatt gcctgcgatc
    11461 cccgggggtt cgtagtcccc gcccttcgag cgcgtacgta cgacgtgcac gcagaaggct
    11521 gcgtccgcac ctgcagcctg gactgtgtag tcggcgccgg aaggcttgtt caagggagcg
    11581 gcgccggcat ccacgccgct ctgcggtgcg ccgccgccac cgttctcgac gacctcgtcc
    11641 tcgatcatcg tcgcgaactc ctcgtcgaag ccgctgtcct cgccgtagat gtcgctgaag
    11701 cgcgacgtgc cgttcaactc ctccgttgcc tggccgaccg catgggacag ctcgtcgtcg
    11761 ctccactccg cgtcagcgac cacggccatg aactgaaacg cggagaagac gccgatcccc
    11821 gccatcccga agagggcgac acgcgccacg acgaaggcgg aatccggcac ctccggcgcc
    11881 gaaggactga gcgaccggcg ccaccgccgg acctggtccg ccctgacaca gcccatggcg
    11941 acgagaccgg cagccagcac cagaagaagc acgaccattg ctttcagagc tcccactctt
    12001 ctcaccgagg tctgttccca ccgaggcggg cggcaaccac ggcgtactgc cgctgtcacc
    12061 gcccgccccg gtcccgccat aagccctacc ggtccccgtc catgagcccc gactgcacca
    12121 gcgggttccc gcggcggcgg gtgacgaaga cgccgcgccc cgggggcatc ggacgcgggc
    12181 gtacgttgcc gaggatgtcc ccctcgatgg ggtcgcccga gagcatcagg ccctgcgcgc
    12241 ccagctccag gatgcgctgc aggaacggct cgtacagggc gcggcccgcg cccgccgtgc
    12301 tgcgggcgat gatgaagcgc acgccgacgt cacgcgagaa cggcagcatc tccgtgagct
    12361 tcgccagcgg gttgccgctg gacgtcgaga ccaggtcgta gtcgtcgacg accacgaaca
    12421 cgtccgggcc gctccaccag ctgcggtcac gcagctcctg ggccgtgacg tccggcgagg
    12481 gcgtacggcg cttcatcagg tcgtacagcg cgtccatgtg gtgctccatg ttgttggaca
    12541 tgggcacgta ctcggccagg tgcgtcgccg gggtgacgtc caggagcgct cgccggttgt
    12601 cgatgacgaa gaacttggcg gcgttcccct cgtaccgctc cgtcagctgc ttgatgagca
    12661 gacgcagcag gttggacttg ccggactcgc tctcgccgaa caccaggaag aacgggtccc
    12721 gctcgaagtc gaggaagacc ggctccaggt tgttctcgtc gatgccgaac gcgatgccgc
    12781 gctccggccg cgcgtagccc gcgggcaggt cgtggaccgg gagttcccgg ggcagcagcc
    12841 ggaccgccgg ggccggcgcc gcggtccagt gccgggcgac ctcctggttc atcgcggccg
    12901 tggcctcgga gaggtcgctg tcggagttga tgccgtcgat ccgcggcacc gcggccatga
    12961 agtgcagctt ctccggggtc agaccgcgtc cgggcacccc gggcggcacg ttgaccgcgg
    13021 ccttgcggtc cagctccgag tccatgacgt caccgagccg cagctccagc cggttcatca
    13081 ggtggtcctt caggttggcc cggacctcca tggagcgcga cgccgtgacg atcaggtgga
    13141 tgccgtaacc gagaccgcgc tgcgcgatgt cgatcgccgc agcttccagg gcctcgtagt
    13201 ccgtgcggaa gttgccccag ccgtcgatga gcaggaagac gtcgccccac ggctggtcgg
    13261 tcaccgagat gtcgccgcgc gcccgcagcc tgcggaacgt ggcgatcgag tcgatgccgg
    13321 cgctgcggaa gtactcctcg cggcgcgcca tgatcccgta cacctcggag accgtacggc
    13381 gcacccgctc ggggtcgagc cgggacgcga tcccgccgac gtgcggcagg ccggagaccg
    13441 aggccaagcc accgccaccg aagtccagcc cgtagaactg gacctcctgc ggcgtgtggg
    13501 tgagggcgaa gcccgcgatc agcgtgcgca gcagcgtgga cttgcccgac tgcgggccgc
    13561 ccgtgatctg catgtggccc gccgcaccgg agaagtcccg gtagagcgtg tcgcgccgct
    13621 gctcgtacgg cttgtcgacc acacccagcg gtacgacgag acgccccgag ccctcgaacc
    13681 cgggctgggt cagcccacgg ccctccaccg cggagagccc cggaaggagc tcgtccagcg
    13741 acggcggatt gtccagcgga ggaagccaca cctggtgcgc tgaagccccc cggccctcca
    13801 gccggcgcac gatcacgtcg agcaccgtgt cggccagcgc gtcgtcctcg gccttacggg
    13861 cctccggcac accgggccgc tccgtcggct gcacatagcg gacgggcacc ggagccgcgg
    13921 tgaacaccac gggcctgcgg tccaccggca gcggaccgga ggacaccacc ggctgcgcgc
    13981 cggagcggta caccccggag acgtacgccg ccttgaagcg caccatctcg tccgtgccgt
    14041 atttcagata acccgaaccg ggcacattgg gcaggtggta cgcgtcgggc acgcccagcg
    14101 cggcgcggga ctcgcccgcg gagaacgtac gcagaccgat ccggtacgac aggtaggtct
    14161 ccagcccgcg cagccgcccc tcctcgaggc gctgcgaggc cagcagcaga tggacgccca
    14221 gcgaacggcc gatacggccg atctgcacga acatctcgat gaagtccggc ttggcggtga
    14281 gcagctcgct gaactcgtcg atgaccagga cgagggaggg gatgggctgc agcggcgcgc
    14341 cggcggcccg ggccttctcg tagtcgtgga tgttggcgta gttgcccgcg tcgcgcagca
    14401 tctcctggcg gcggttgagc tcaccgctga tggagtcgcc catgcggtcg acgagcgtca
    14461 ggtcgtccgc gaggttggtg atcaccgccg cgacgtgcgg catctgcgcc ataccggcga
    14521 aggtggcacc acccttgaag tccgcgagga cgaagttcag cgtctccgaa gtgtgggtga
    14581 cggcgaggcc caggacgagc gtacggagca gctcggactt gccggaaccg gtggcgccga
    14641 cgcacaggcc gtgcggcccc atgccctcct gcgccgcctc cttgaggtcc agcatcacgg
    14701 gggcgccgtc ctcacccaca ccgatcggga cccggagccg ctccgcctgc gagcggggcc
    14761 gccaggtccg gctgacgtcg accgaggcgg cgtcaccgag gttcagcaga tcggtgaact
    14821 ccaggttggc gagcagcggt tcgtcgtcgt ccccgcccga ggccacgtgc aggggggcca
    14881 gctgccgtgc cagggcctcc gcggcctcgt ggctcagcag gtcggggagg ccgtcgtaca
    14941 cgaggccgtt gcccgactcc agctgcaggg agtgcgggtc caccacgatg gagagcccgc
    15001 cgcgcgcgcc gttgacctgg ccggtgacga tctcgacgac cgacacgccc tggaggccct
    15061 ccgccgaggc gagcgccgac gtcgcgggta cggactcgcc gtcgagcacg acgacgacat
    15121 gcggctggtc gaggagcggc tgaccgccgg gctggaagcg cggccggccg tcgaggcggc
    15181 ccgcgagcat ctcctccagc tcggcgacgc tcgtggtgat caggcggcgg ctgccggccc
    15241 cgtcgatcga gccctggacc tggacgtgcg ggagccactt cgtccactcc cagcgaggag
    15301 cggcgtcacg gccggtcgcg acggcgatga tcaggtcctc gggggagtgc agcgaggcga
    15361 gcgccccgac catcgcgcgg gcggtggcac gggcggactc cgcctcgccg ctgatcgtca
    15421 ggtggtagaa ggcgcggagc gagaccgcca tcggcagccc gtccagcgtg ctgtgggtcg
    15481 tcaggaactg ctgcatcgcc ccggcggtca gcggctccag ctcgtcgacc ggagccgtgt
    15541 cgggggcgac gagcggtgtg gcgagctcct ggctgcccag gccgatgcgt acgtgcgcga
    15601 agtcggcgtc accgacgcgg cgctcccaca cccggctgcc ctcggcgacg agcgcccaca
    15661 gctgctccgg ggacgggtgg aggtagaact gcgcgtcgcg ctgctgccgg gcggtcctca
    15721 gcacggcacg gcgggtctgg gtcagatact tcaggtagtc gcgtcgcatg tccgcgagct
    15781 ggccctgggt gccgcgccgg aagcggatga tcatcgagat ggccatggcg atcgtcgacg
    15841 cgatcatgac catgcccatg atccgcatga tcgggttcgg cgtcatgaag aagaagacga
    15901 cggaaccacc catgccgagc atcggcagca gctgcatcat caccccctcc tgctgcccgc
    15961 ggggcagctc gggcggaggt tgcaactgca cctgctcgcc cggaacttcg gaggggaggg
    16021 cccgcggtgg gcgcttgacg acaatctggc tcacagctca ccaattccct tgccggacgg
    16081 aactgttcct atcggcgccc ccgtggcgac gggttccgtc cgcgggagga tcctactggc
    16141 gtacccggcc acccgagggc ggtagggtgt cgcgacgcgt gtacgcatcc gctaactacc
    16201 gcaaaaaaat gggtcattcg ggacgcagtc ggagcccgtg acccaggggg tgcgttccac
    16261 agagatccag gagaaccatg agggggagca gcacgtgact atgacggccc aaacggcggc
    16321 taccggatcc ggtcggccgg gtcccggagt tccggccggc aacggaaccg gcttctgccg
    16381 ggtcacggtc gtcgcgcccg acagtcgcgt cgatgtggcg ctgcccgagg acatccccgt
    16441 cgccgacctc tacccggaga tcctccggct ctcggggcag agccccaccc agggcgcccc
    16501 cgtcggctac cacctggtgc gccgggacgg cacggtgctc gacagcgggc gcacgctggc
    16561 cggccagcgc atcctcgacg gtgagctgct gtccctccgc cccttctcgg agtcgctgcc
    16621 gcccgccgtc ttcgacgacg tctccgacgc cgtcgcctcc gcggtcgccc gggaccgcac
    16681 gctctggggc gacaccctca tgcgctcggc cggcctcttc ggcggatcgg tcctgctggt
    16741 cctgctcggc ttcgtcctgt ggacctccga cgtccggcac gacatgcacg ggctgccggg
    16801 catcctcgcg gccgtcgccg ccctgctcct tctcgcgctg gcgtgcgtac gcgcgcgcgt
    16861 ctacgacgac cgcggttcgt ccatcgcgct ggggatcggc gcactgacca gcgccgcggt
    16921 cggcggcgcc gggctcctgc cgctcagcac gggacagggc gtcggcaggc tccagttcct
    16981 cctcgcctgc gccgccgtcc tggtggtgtc ggtgatcctc atgatcgccg cccccgaggg
    17041 cgacgggacc ttcgtcgcgt tcgtgttcgc ctccgccatc ggcgtactgg tgaccttcat
    17101 cgcgatcatg accggcatgg agccggccga gaccgcggcc gtgtgcgcgc ctctgtccgt
    17161 ggggctcctc ggcttcctgc ccggactctc cacccgcttc gcccggctcc cgatcggctt
    17221 cgagccgccc cgcaccacca ccggtgacta cggcacgtcc gaccccgccc cgcagggccc
    17281 cgtcgacgcc gaccgcatcg ccgcccaggc gcggcgcggc cacgaactgc tcctcggcct
    17341 ggtcggcgga tgcgcgctgg tggccgtggg cgccgccgcg gtgctcggct tctcggacag
    17401 cgtctggggc cagctgctgg cgctcgccac cggggctgcg atgctcatgc gcgcccacct
    17461 gttccgctac acggcccagg tcggctgcgc cctcggcgcg ggcctcgccg cactcgtact
    17521 cctcggcctc gggctgtcac tcaacccgcc ggccgagctg ttcctggacg cgttcaaggg
    17581 cgacaccacg ggactcgaca tccgtacgat ctggctcacc gccgcggtcg ccggcgtcgc
    17641 cgcgctgatc accgccatcg ggctgatcgt gccgcgcaag ggagtcaccc ccttctgggg
    17701 acgcttcctg gaggtcgccg aggcctgcgt gctcctgacg ctcctgccgc tctgcctggc
    17761 ggtcttcgac gtctaccact cgatccgggc actcaccagc tgacgcccgt caggggcgct
    17821 ccgaacgact ggtactctga ccagtggccg tttgtgtacg cgtccccgga tcatcctggg
    17881 ggctgcgctc atcggacctt cgcctccgag tcatggaagc tcccctgaga tcaagaccag
    17941 gggcactcgt gggcgcatcg aacatcaaag aggagtacgc gtgccgctcg acgccgctac
    18001 gaagaagcag atcatgtccg agttcgccca gaaggagggt gacaccggat cccccgaggt
    18061 ccaggtcgcc atgctctccc gccggatctc ggacctgacg gagcacctca agacgcacaa
    18121 gcacgaccac cactcccgtc gtggtctgct gatcctggtc ggccagcgtc gccgcctcct
    18181 gcagtacctg gccaagaagg acatccagcg cttccgtgcg ctcgtcgacc gcctcggcat
    18241 ccgccgtggc gcggccggcg gcgccaagta aagacgctgt cgaagggagc ggtacccact
    18301 tccaggggac cgctcccttt gccgtacgtg cggtaccggg cccaagctca gtaacctgga
    18361 cgtacaacac aagacgagga gaggcgcccc acggccgccg ccggtcctcg gtagtggccc
    18421 ccgggacaac gcccgggagc ttcgatcgaa gaccggcccc gcacacacgg tgcgcttctc
    18481 cgcaccgtcc tgcgccacac gggcgccagg acgaaagacg acgagtatgg agaaatcact
    18541 agtggagaac gagacccact acgccgaggc cgttatcgac aacggaacct tcggcacccg
    18601 caccatccgc ttcgagacgg gccgcctggc caagcaggcc gccggctccg ccgtcgcgta
    18661 cctggacgac gacaccatgg tgctgtcggc caccaccgct tccaagcggc ccaaggacaa
    18721 cctcgacttc ttccccctca cggtggacgt cgaggagcgg cagtacgccg ccggcaagat
    18781 ccccggctcc ttcttccgcc gggagggccg cccctccgag gacgcgatcc tcacctgccg
    18841 cctgatcgac cgcccgctgc gcccctcctt caagaagggc ctgcgcaacg agatccagat
    18901 cgtcgagacg atcatggcgc tcaaccccga ccacctgtac gacgtggtcg cgatcaacgc
    18961 cgcctccgcc tccacgatcc tggcgggcct gcccttctcc ggcccgatcg gcgccacccg
    19021 cgttgccctg atcaagggcc agtgggtcgc cttcccgacg cacaccgagc tcgaggacgc
    19081 cgtcttcgac atggtcgtcg ccggtcgcgt cctggaggac ggcgacgtcg cgatcatgat
    19141 ggtcgaggcc gaggccaccg agaagaccat ccagctcgtc aaggacggcg ccgaggcccc
    19201 gaccgaagag gtcgtcgccg ccggtctgga agcctcgaag cccttcatca aggcgctctg
    19261 caaggcccag tccgacctcg ccgccaaggc cgccaagccc accggcgagt tcccggtctt
    19321 cctcgactac caggacgacg tcctggaggc gctcaccaag gccgtcagca ccgagctcgc
    19381 caaggcgctc accatcgccg gcaagcagga gcgcgaggcg gagctcgacc gcatcaagga
    19441 catcgcgggc gagaagctcc tcccggcctt cgagggccgc gagaaggaga tctccggtgc
    19501 ctaccgcgcg ctgaccaaga agctggtccg cgagcgcgtc atcaaggaca aggtccgcat
    19561 cgacggccgc ggcgtcacgg acatccgtac gctcgccgcc gaggtcgagg ccatcccgcg
    19621 cgtgcacggc tcggcgctgt tcgagcgtgg cgagacccag atcctgggcg tcaccaccct
    19681 caacatgctc cgcatggagc agcagctgga caccctctcc ccggtgaccc gcaagcgcta
    19741 catgcacaac tacaacttcc cgccgtactc cgtcggtgag accggccgcg tgggctcgcc
    19801 caagcgccgc gagatcggcc acggcgcgct cgccgagcgc gccatcgtgc cggtgctgcc
    19861 gtcgcgcgag gagttcccct acgcgatccg ccaggtctcc gaggcgctgg gctccaacgg
    19921 ctcgacgtcc atgggctcgg tctgcgcctc caccatgtcg ctgctgaacg ccggtgtgcc
    19981 cctcaaggcc gccgtcgccg gtatcgccat gggcctgatc tcgcaggaga tcgacggcaa
    20041 gacccactac gtcgccctca ccgacatcct cggtgcggag gacgccttcg gcgacatgga
    20101 cttcaaggtc gccggcacga agcagttcgt gaccgcgctc cagctcgaca ccaagctcga
    20161 cggcatcccc gcctcggtcc tggccgccgc gctgaagcag gcccgtgacg cccgcctcca
    20221 catcctcgat gtgatgaacg aggccatcga cgtcccggac gagatgtccc cgaacgcccc
    20281 gcggatcatc accgtcaaga tcccggtgga caagatcggt gaggtcatcg gccccaaggg
    20341 caagatgatc aaccagatcc aggaggacac cggcgccgac atcacgatcg aggacgacgg
    20401 caccatctac atcggtgccc agcagggctc ccaggccgag gccgcccgcg ccacgatcaa
    20461 cgccatcgcc aacccgacca tgccggaggt cggcgagcgc tacctgggta cggtcgtcaa
    20521 gaccaccacc ttcggtgcgt tcgtctccct gatgcccggc aaggacggtc tgctgcacat
    20581 ctcgcagatc cgcaagctcg ccggtggcaa gcgcgtggag aacgtcgagg acgtgctcgg
    20641 cgtcggcgcc aaggtccagg tcgagatcgc ggagatcgac tcccgcggca agctctcgct
    20701 catccccgtc atcgagggtg aagaggacga gaagaaggac gacaccgaca agtgacgtcc
    20761 cgtagttccg tgacgacggc ccgcccctcc tcggaggggc gggccgtcgc ccgtacccaa
    20821 acgcttctca agggcagcaa cggcatcggc acggtccgcc gcacggtcct ccccggcggc
    20881 ctgcgcgtgg tcaccgagac cctgccctcc gtacgctccg ccaccttcgg gatctgggcc
    20941 aacgtcggat cacgcgacga gacgcccacc ctgaacggcg cgacccacta cctcgaacac
    21001 ctcctcttca agggcaccgc caagcgcagc gccctcgaca tctcgtccgc gatcgacgcg
    21061 gtcggcggcg a
//
