LOCUS       NZ_RDBM01000024        10494 bp    DNA     linear   CON 01-JAN-2025
DEFINITION  Streptomyces sp. gb1(2016) Scaffold_24, whole genome shotgun
            sequence.
ACCESSION   NZ_RDBM01000024
VERSION     NZ_RDBM01000024.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. gb1(2016)
  ORGANISM  Streptomyces sp. gb1(2016)
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 168112)
  AUTHORS   Hariharan,J., Choudoir,M.J., Diebold,P., Panke-Buisse,K.,
            Campbell,A.N. and Buckley,D.H.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-OCT-2018) Soil and Crop Sciences, Cornell University,
            306 Tower Road, Ithaca, NY 14850, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2018
            Assembly Method                   :: A5+MeDuSa v. JUNE-2018
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 66x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_008042065.1-RS_2025_01_01
            Annotation Date                   :: 01/01/2025 02:23:01
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,414
            CDSs (total)                      :: 7,333
            Genes (coding)                    :: 6,887
            CDSs (with protein)               :: 6,887
            Genes (RNA)                       :: 81
            rRNAs                             :: 6, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 447
            CDSs (without protein)            :: 446
            Pseudo Genes (ambiguous residues) :: 0 of 447
            Pseudo Genes (frameshifted)       :: 94 of 447
            Pseudo Genes (incomplete)         :: 395 of 447
            Pseudo Genes (internal stop)      :: 7 of 447
            Pseudo Genes (multiple problems)  :: 48 of 447
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:17:57
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 157618
            Orig. end                         :: 168112
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            RDBM01000024.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10494
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="melanin"
                     /region_number="2"
                     /rules="melC"
                     /tool="antismash"
     cand_cluster    1..10494
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="melC"
                     /kind="single"
                     /product="melanin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10494
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[5000:5528](-)"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5528)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
     misc_feature    105..123
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 21.57"
                     /tool="antismash"
     gene            651..1817
                     /locus_tag="EAO74_RS07850"
                     /old_locus_tag="EAO74_07860"
     CDS             651..1817
                     /EC_number="2.4.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045: glycosyl transferase group 1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018487589.1"
                     /locus_tag="EAO74_RS07850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EAO74_07860"
                     /product="glycosyltransferase"
                     /protein_id="WP_147983156.1"
                     /sec_met_domain="Glycos_transf_1 (E-value: 1.5e-21,
                     bitscore: 70.1, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRALHVITGLGVGGAEQQLRLLLRHLPVRCDVVTLTNPGAVADGL
                     RADGVRVRDLGMRSNRDLGAVPRLARLIRRGSYDLVHTHLYRACVYGRIAARLAGTTVV
                     STEHSLGRAEIEGRPLTRGTRELYLRTERLGAATVAVSDTVAGRLRDWGVPAARIHTVP
                     NGVDVAAFRFDSARRQTTRAALGLPGTAFVVGGVGRLVPGKRFDLLIRAVAALPGAWLV
                     LAGDGPEAGALRALAARLGVAGRVRFLGECGAPGGAAPDIPAVLSAVDTFASASREESF
                     GLAVVEALAAGLPVVHAACPAIEDLPADRAPGAVRIGSASGAGDPTEELTAALRHRLEG
                     GARRLPPPPAVDHYDIRISSRRLLDVYAQALDTPTATPTVTPTERALP"
     misc_feature    669..683
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.64"
                     /tool="antismash"
     gene            1814..2482
                     /locus_tag="EAO74_RS07855"
                     /old_locus_tag="EAO74_07865"
     CDS             1814..2482
                     /GO_function="GO:0004713 - protein tyrosine kinase activity
                     [Evidence IEA]"
                     /GO_process="GO:0009103 - lipopolysaccharide biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012377858.1"
                     /locus_tag="EAO74_RS07855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EAO74_07865"
                     /product="YveK family protein"
                     /protein_id="WP_124278723.1"
                     /transl_table=11
                     /translation="MTESPEQQPAVPGRLRRLRPTSLRPTWWPLPACVLLGAACGFSYG
                     MLAQPEYAATSYAMVTAGKGIDPAAALGYAQSYGRLATSDATLSYAKGAAGEPVRELRA
                     HVRSETSPDSPMIAVTGTSVSRGRAADIANAVTEAVVVSSGHVAKDTGVKLVKFSHAVP
                     PVDPVSPSAPLGTAVGASAGGLVGGLILLVRPRSGRRGVTAQVPGPTHGGTTGERELVR
                     "
     gene            2479..3645
                     /locus_tag="EAO74_RS07860"
                     /old_locus_tag="EAO74_07870"
     CDS             2479..3645
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014157953.1"
                     /locus_tag="EAO74_RS07860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EAO74_07870"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_147983157.1"
                     /transl_table=11
                     /translation="MNIDRRGRLTVTLCRDLPDFVDLAPEWNALHRRCPTATPFQSHAW
                     LHSWWLSYGTPGRLRVVLVRRDGRLIGAAPLMLVHRPMPLLVPMGGAISDYFDILVDGE
                     DVPAAVTALERGLHRAASHTVVDLREVRPDASAHLLFEAWSGARSSRTDSTCMELPTEP
                     IDALIGRMTGSRAQRARAKLRRVDALGIECRTAPVHGVAGAIGSLLRLHELQWLGRGVN
                     PEHLRPRFCAHLVRSARRMVRDGEASVREFLLDGEVVAADVSFRSARLTGGYLYGADPR
                     LRETKVDVSSMLLREIAREADGLDRGVLSLLRGSEQYKSHWGPVPVVNRRLMLARSSLE
                     PLLRLRETQVNVRERAAGTVKSRLPAAREWRGRLSELPAAGAALIGRS"
     gene            3756..4037
                     /locus_tag="EAO74_RS07865"
                     /old_locus_tag="EAO74_07875"
     CDS             3756..4037
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015575906.1"
                     /locus_tag="EAO74_RS07865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EAO74_07875"
                     /product="chaplin"
                     /protein_id="WP_099171400.1"
                     /transl_table=11
                     /translation="MSRISKVAAVMAGTGALIAGGAGMATADSGAEAVAAHSPGVISGN
                     AVQVPVSIPVNVCGNTVNVIALLNPAFGNTCANVSDSHEDEGEYGYGH"
     gene            complement(4120..4980)
                     /locus_tag="EAO74_RS07870"
                     /old_locus_tag="EAO74_07880"
     CDS             complement(4120..4980)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014157951.1"
                     /locus_tag="EAO74_RS07870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EAO74_07880"
                     /product="tyrosinase family protein"
                     /protein_id="WP_147983158.1"
                     /transl_table=11
                     /translation="MYSRKNQRDLTRTEKKRLVDAILELKRSGRYDDFVSLHRQYYVTD
                     AESRPRPAHMTPSFFPWHRRYLLEFEKALRAVDPRVSVPYWDWTRDNTASSSLWADDFL
                     GGNGRPGDRQVMTGPFAYRQGNWRIRGGVTDDPFLRRNFGRPSSPVTLPAAAEVERALK
                     DPVYDTEPWNSVSTTGFRNRIEGWGIRGGRGVANHNRVHRWIGGSMAGAASPDDPVFWL
                     HHAFIDLLWTRWQKAHPRSRYLPARELPAGDPQRDRIFSLDRPMPPWDVAPSQLMDHSR
                     LYRYV"
     gene            complement(5001..5528)
                     /locus_tag="EAO74_RS07875"
                     /old_locus_tag="EAO74_07885"
     CDS             complement(5001..5528)
                     /GO_function="GO:0005507 - copper ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0042438 - melanin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     melanin: melC"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014157950.1"
                     /locus_tag="EAO74_RS07875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EAO74_07885"
                     /product="tyrosinase family oxidase copper chaperone"
                     /protein_id="WP_147983159.1"
                     /sec_met_domain="melC (E-value: 2.8e-46, bitscore: 150.5,
                     seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNPTDGTKGEPAGAPRPARRAVLRTAFTAAVIAGTGGALAPVLLG
                     TQGPAGADRERGAVGPERFSELYKGREIRGTVTTTVPAGAQPYAGAQPDDGKQPHAGAQ
                     PYAGEAGTAAAVTGTEVSVDGRPLHVMRRADGSYLSTVNHYESFPTLLETARAAVDELG
                     PAQLSAASPHTI"
     misc_feature    complement(5596..5611)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.83"
                     /tool="antismash"
     misc_feature    5717..5728
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.76"
                     /tool="antismash"
     gene            5721..7010
                     /locus_tag="EAO74_RS07880"
                     /old_locus_tag="EAO74_07890"
     CDS             5721..7010
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014044247.1"
                     /locus_tag="EAO74_RS07880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EAO74_07890"
                     /product="cytochrome P450"
                     /protein_id="WP_147983160.1"
                     /sec_met_domain="p450 (E-value: 2.3e-18, bitscore: 59.5,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNAPTQVSTVRVRGTAGADLADPAFWRLPRHERLSAFARLRELDA
                     PALFTPRTGSRTPFYAVVRHADVKSASRQPQLFTSAPGVTTPEPAPWAKAVFGNSMVNM
                     DGAEHAGLRRTISRAFTPRLLAAAEENIDAVARRLVDEAAAAGPGDFMRAAPSRMPFEV
                     ICDLMGIPARHRARIAARIDHASEYVGVQRRGRARLRIPGRGLRSLARMQLEMAGIARE
                     RRRVPADDVISALVRADVGGQALSSRQLGAFFSLLLVAGVETTRNAIAHGLVLLTEHPE
                     QRALLESDFDRYADGAVEEIVRHSTPIIQFRRTVAAECALGGRTFLPGEKVVLLYASAN
                     RDASVFDDPDAFDITRSPNPHLGYGGGGPHHCLGAHLAKLELKALFREMLTRPVNIRAS
                     GEPGLVDSNFDNRVGSLPFIFDRSHPNGPL"
     gene            7122..8318
                     /locus_tag="EAO74_RS07885"
                     /old_locus_tag="EAO74_07895"
     CDS             7122..8318
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015575909.1"
                     /locus_tag="EAO74_RS07885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EAO74_07895"
                     /product="glycoside hydrolase family 26 protein"
                     /protein_id="WP_124278718.1"
                     /transl_table=11
                     /translation="MPVQRRLTNFGVGATALCLLVGGAVLADRDAEDTQAGKGAAQQAP
                     EPGTTTAIGAYLDYGPKGVQRMGELSRWLGGTEMRVGHSYLPGDLWENIEGRPGFLASW
                     AAWRKAADDRMFVLNTPMLERNEEHVSDDEVRGLLRDGAEGRFDEHFRRLAERLVLLGV
                     PDTVIVLGWEMNGTTYTHRCGPDPVAWKAYWNRIVTTMRSVSGQEFRFDFAPSRGRDAV
                     PWTECYPGDDVVDIIGMDSYDQPPARDFDEQVNEPYGLQKQVDFAAEHGKPISFPEWGL
                     FRNGDNPEYMRRMLEWIEQHKPVYQTITDYCPHGVWQCSENPESSRVFREMLSGLPNAT
                     EPSAPAADPSGTPTAPKPDKPTPTVPTPDTNGSGWCFTVPLSDWFGQWLSDREFCVRG"
     gene            8505..9089
                     /locus_tag="EAO74_RS07890"
                     /old_locus_tag="EAO74_07900"
     CDS             8505..9089
                     /EC_number="1.-.-.-"
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EAO74_RS07890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EAO74_07900"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_261988188.1"
                     /transl_table=11
                     /translation="MSDRKAVSRGRAVAFFGSVSRNLLDAGARAGVHHHVALSIVGIDR
                     VGHGYYQGKLRQEEVVRGGRVPWTVLRSTQFHEFVSQALQQMPGPVAVVPRMNIQPVAA
                     REVARHLVELALAPPRGMAPELAGPRVELLVDLVRRLLHARHERRLVVPVRLPGAVGAA
                     MAGDGQLPAGAGPRGSRTFDEWLAGAVTRGA"
     CDS             complement(9126..>10492)
                     /codon_start=2
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018514009.1"
                     /locus_tag="EAO74_RS07895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EAO74_07905"
                     /product="hypothetical protein"
                     /protein_id="WP_410089274.1"
                     /transl_table=11
                     /translation="PEPARTDEPAGRRRDLTAAAAGVLLVAAAIGIGWVIQQGDGSLQV
                     QWPPLLASWDPHLGPGTPAAVAVAVAVVAYGPRLAARLPWRRLLLTCWAGSVAWILSLA
                     LIEGWYRGIARRLTTKHEYLRVIDRFDDIGAALRGFTDHIVIGPPGNWPAHVAGHPPGA
                     TLTFVGLDRAGLGGGAWAGMWCIVLGGSAAVAVLVALRALTDEHLARRAAPFLVLAPFA
                     VWTGTSADGYFAAVAAWSVALLALAATRTARHPGATALGSGLLFGLTCYLSYGLTLIAV
                     LLGAVLLLTRTARPLAPLALGALVAPVAFTLAGFSWWEAYHLLVERYYQGAGGTRPYSY
                     WVWANLACTTLAAGLATVAGLRRAAVSAPAAVRGVRPGTTTAAQRLALLTLAALLALAV
                     ADLSGMSKAETERIWQPFVVWLMPAAALLPGPGRRGWLAAQAVVALLVNHLLWTGW"
     gene            complement(9126..>10494)
                     /locus_tag="EAO74_RS07895"
                     /old_locus_tag="EAO74_07905"
ORIGIN
        1 tccgccgacc gtctggacga gcagctgacc tggctgcgcc gccggggcct gaccggcgtg
       61 ggggtcgccg cgctgctgcg tgcgcgggcc gccgggaagg gcgggctggt cgggctcacc
      121 ttcgacgacg ggtacgccga cttcctcgac gaggcgctcc cggtgctgct cgcccacggc
      181 tgcagcgcga cggtgttcgt ccttcccggc aggccaggcg gctccaacac ctgggatccg
      241 ctcggcccgc gcagaccgct gctgaccgag gagggcatcc gtacggtcgc ggcggcgggg
      301 atggaggtcg gctcgcacgg gatgctccac cgggatctga cggcgctgtc cgacgaggag
      361 ctccgggagg agacgcacgg cagccgggac gccctgcacc gcctcgtccg ggaggcgccg
      421 tccggcttct gctacccgta cggcacggcc gaccggcggg tggtcgagtc cgtccgggag
      481 gcggggtacg cctatgggtg cgcgctcgtc cccggttccc tggcggggcc gctcgccctt
      541 ccccgtacgc atgtcagcca cgccgaccgg ggtgcccgtc tgcgggccaa ggagatcagg
      601 caccggctgc ggaaccgctc cgtcggcgcc acggggccgg gtgacgcggg gtgagagcac
      661 tgcacgtcat caccggtctc ggtgtcggcg gggcggagca gcagctgcgt ctgctgctgc
      721 gtcatctccc ggtgcgctgc gacgtcgtga cgctcaccaa ccccggggcg gtcgcggacg
      781 ggctgcgcgc cgacggtgtc cgggtccggg atctggggat gcggagcaac cgggacctcg
      841 gcgcggtgcc ccggctggcc cgtctcatcc gccgcggctc ctacgacctg gtgcacacgc
      901 acctctaccg ggcctgcgtc tacggccgga tcgcggcgcg cctggccggg acgaccgtgg
      961 tgtcgacgga acattcgctg gggcgcgcgg agatcgaggg gcggccgctc acccgcggga
     1021 cccgggagct ctatctgcgc accgagcggc tgggggcggc gacggtcgcc gtctccgaca
     1081 ccgtcgcggg caggctccgc gactggggcg tgccggccgc gcggatccac accgtgccca
     1141 acggggtgga cgtggccgcc ttccgtttcg acagcgcacg acggcagacc acccgggccg
     1201 cgctggggct tcccggcacg gccttcgtgg tgggcggtgt gggcaggctg gtccccggca
     1261 aacgtttcga cctgctgatc cgtgccgtcg ccgcgctccc cggtgcctgg ctggtcctgg
     1321 ccggggacgg gccggaggcc ggggcgctgc gcgcgctcgc cgcccggctc ggtgtcgccg
     1381 gccgcgtcag gttcctcggc gagtgcgggg ccccgggagg tgccgctccg gacatcccgg
     1441 cggtgctcag cgccgtcgac acgttcgcct cggcgtcccg cgaggagtcc ttcggtctcg
     1501 ccgtcgtcga ggccctggcg gccgggcttc ccgtggtgca cgcggcgtgc ccggccatcg
     1561 aggacctccc ggcggaccgg gccccgggcg ccgtccggat cggttccgcc tccggtgccg
     1621 gcgatcccac ggaggagctg acggcggcgc ttcggcaccg gctggagggc ggcgccagga
     1681 ggctgccgcc gcctccggct gtcgaccact acgacatcag gatcagcagc cggcgcctcc
     1741 tggacgtcta cgcacaggcc ctcgacaccc ccacagccac cccgacagtc accccgaccg
     1801 agagagcact cccatgaccg agtcgcccga gcagcagccg gccgtccccg gacggctgcg
     1861 caggctccgc cccacatccc tacggcccac ctggtggccc ctgcccgcct gcgtcctgct
     1921 cggggccgcc tgcggattct cgtacggcat gctcgcccag cccgagtacg cggccaccag
     1981 ttacgccatg gtcaccgcgg gcaagggcat cgatccggcc gccgccctgg ggtacgccca
     2041 gtcgtacggg cgcctggcca ccagcgacgc caccctctcc tacgccaagg gcgccgccgg
     2101 ggagcccgta cgtgaactcc gcgcccacgt acggtccgag acctccccgg actcgcccat
     2161 gatcgcggtc accggtacct ccgtgtcgcg cggccgtgcc gcggacatcg cgaacgcggt
     2221 gaccgaggcg gtggtcgtga gcagtggtca cgtcgcgaag gacaccggtg tgaagctggt
     2281 gaagttctcg cacgccgtac cgcccgtcga tcccgtctcc ccgtccgcgc cgctcggcac
     2341 ggccgtgggc gccagcgcgg gcgggctggt cggcgggctg atcctgctcg tccgcccccg
     2401 gtccggacgc cggggagtga cggctcaggt gccgggtccc acccatggcg gcaccacggg
     2461 cgaacgggag ctcgtgcgat gaacatcgac cgccgtggac ggctcaccgt gaccctctgc
     2521 agggacctgc cggacttcgt ggacctcgcc ccggagtgga acgcgctgca ccgcaggtgc
     2581 cccaccgcca cgccgttcca gagccacgcg tggctccatt cgtggtggct ctcctacgga
     2641 actcccggcc ggctccgggt cgtactggtg cgcagggacg gacggctgat cggcgcggcg
     2701 ccgctgatgc tcgtgcaccg cccgatgcct ctgctggtgc cgatgggcgg agcgatctcc
     2761 gactacttcg acatcctggt ggacggcgag gacgtcccgg cggcggtcac cgccctggag
     2821 cgcgggctcc accgggcggc ctcgcacacc gtcgtggacc tgcgggaggt ccggcccgac
     2881 gcctcggcgc acctgctgtt cgaggcgtgg tccggcgccc ggagcagccg caccgactcg
     2941 acctgtatgg agctgcccac cgagccgatc gacgccctca tcgggcggat gaccggttcg
     3001 cgcgcccagc gggcgcgggc caagctgcgc agggtcgacg ccctgggcat cgagtgccgt
     3061 accgcgccgg tgcacggggt ggcgggggcg atcggcagcc tgctgcggct ccacgagctc
     3121 cagtggctcg gcagaggcgt caacccggag cacctgcggc cccggttctg cgcgcatctg
     3181 gtgcgctccg cccgccggat ggtgcgcgac ggggaggcct cggtcaggga gttcctgctc
     3241 gacggcgagg tggtggccgc cgacgtgtcg ttccggtcgg cgcggctgac cggggggtac
     3301 ctctacgggg ccgacccccg gctcagggag acgaaggtgg acgtctcctc gatgctgctg
     3361 cgcgagatcg cgcgggaggc cgacggcctg gaccgtggtg tgctgagtct gctgcgcggc
     3421 tcggagcagt acaagagcca ctggggcccg gtgccggtcg tcaaccggcg cctgatgctg
     3481 gcccgttcct cgctggagcc gctgctgcgg ctgcgcgaga cacaggtgaa cgtccgggag
     3541 cgggcggccg gcacggtgaa gtcccggctt cccgcggcac gggagtggcg cggccggctg
     3601 agcgagctcc ccgcggccgg ggccgcgctg atcggccgga gttgagccgt gatgatgact
     3661 tttgcggcga tccgttaccg tctgtcgact ttcgcgttgt cagggcatac cggtcgcacg
     3721 ctcgcagccg gcttcaaccc cctcaaggag aactgatgtc gcgtatctcg aaggtggccg
     3781 ccgtcatggc aggtaccggt gccctgatcg ccggcggcgc cggcatggct accgccgact
     3841 ccggagcgga ggccgtcgcg gcccactccc ccggtgtcat ttcgggcaac gccgtccagg
     3901 tgcccgtcag catcccggtc aacgtgtgcg gcaacacggt gaacgtgatc gctctgctga
     3961 acccggcgtt cggcaacacc tgcgcgaacg tttcggacag ccacgaggac gagggcgagt
     4021 acggctacgg ccactgatcc ccccgaggca ccgtccgggc cccctccgtc cgcgtccgca
     4081 gcggagggag ggggcccggc ccgcttccgg gggcgccgct cagacgtacc ggtagagccg
     4141 gctgtggtcc atgagctgcg agggcgccac gtcccacggc ggcatgggcc ggtcgagcga
     4201 gaagatccgg tcccgctgcg gatcgccggc ggggagctcc ctggccggca ggtagcggga
     4261 gcgtgggtgc gccttctgcc agcgggtcca cagcaggtcg atgaaggcgt ggtgcagcca
     4321 gaagacgggg tcgtcgggcg acgcggctcc cgccatcgac ccgccgatcc agcggtgcac
     4381 ccggttgtgg ttggccacac cgcggccccc tcggatgccc cagccctcga tccggttccg
     4441 gaagccggtg gtgctgacgc tgttccacgg ctcggtgtcg tagaccggat ccttcagcgc
     4501 gcgctccacc tccgccgccg cgggcagggt gacgggtgac gagggcctgc cgaagttgcg
     4561 ccgcaggaag gggtcgtcgg tgactccgcc tcggatacgc cagtttccct gccggtaggc
     4621 gaacggtccg gtcatgacct gccggtcgcc cggcctgccg ttgccgccca ggaagtcgtc
     4681 cgcccagagg gacgagctcg ccgtgttgtc acgcgtccag tcccagtagg ggaccgacac
     4741 gcggggatcg accgcgcgca gcgccttctc gaactccagc aggtatctgc ggtgccaggg
     4801 gaagaaggac ggcgtcatgt gggcgggccg tggcctgctc tcggcgtcgg tgacgtagta
     4861 ctgccggtgc aggctgacga agtcgtcgta gcggcccgac cgtttcagct ccaggatcgc
     4921 gtcgaccaga cgcttcttct cggtgcgcgt gaggtcgcgc tggttcttcc ggctgtacac
     4981 gcgtgctcgt ccttaagggc tcagatggtg tgcggggagg cggccgacag ctgcgcgggg
     5041 cccagttcgt cgaccgccgc gcgggccgtc tcgaggaggg tggggaagga ctcgtagtgg
     5101 ttgacggtgc tgagatagct cccgtcggcg cgcctcatca cgtgcagcgg cctcccgtcg
     5161 acgctgacct cggtgccggt caccgctgcg gcggttccgg cctcaccggc gtacggctgt
     5221 gcaccggcgt gcggctgttt gccgtcgtca ggctgtgcgc cggcgtacgg ctgtgcaccg
     5281 gccggcaccg tggtcgtgac cgtgccccgg atctcgcggc ccttgtacag ctcggagaag
     5341 cgctcggggc ccacggcgcc gcgctcccgg tccgcgcccg cgggcccctg ggtcccgagg
     5401 aggaccgggg cgagcgcgcc gccggtcccg gcgatcacgg ctgcggtgaa ggcggtgcgc
     5461 agcaccgcgc ggcgggccgg ccgtggtgcg ccggccggct cccccttcgt accgtcggtc
     5521 gggttcatgg tgggtgtacc tccctctcgt gggctcctgc gacgtgtccc gctcgagtgg
     5581 gcaacgagac ggtgcgcgaa cggttctcat ccgcaggaca tcacgcgacc gtggtaattc
     5641 cgtggcgctc cccggccgtg tcggccctgt ggagcggccg gcggggtgag catggccgtc
     5701 cgagctcccg gaggtggtgc atgaacgcgc cgacgcaggt gtccacggtc cgcgtgcggg
     5761 gaacggccgg tgccgatctg gccgatcccg cgttctggcg gctgccgcgg cacgaacggc
     5821 tgtccgcgtt cgcccggctg agggagctcg acgcaccggc cctcttcacc cctcgtacgg
     5881 gctcacgcac gcccttctac gcggtggtga ggcacgcgga cgtgaagtcg gcgagccggc
     5941 agccacagct cttcaccagc gcaccgggtg tcacgactcc ggaaccggcg ccctgggcca
     6001 aggcggtctt cggcaactcc atggtcaaca tggacggcgc cgagcacgcg gggctgcgca
     6061 ggaccatctc gcgcgcgttc acgccgaggc tgctcgcggc cgccgaggag aacatcgacg
     6121 ccgtcgcccg gcggctcgtc gacgaggccg ccgccgcggg gccgggtgac ttcatgcgtg
     6181 cggcgccctc ccgcatgccg ttcgaggtga tctgcgacct gatgggcatc cccgcgcgcc
     6241 accgggcccg gatcgccgcg cgcatcgacc acgcctcgga gtacgtcggg gtccagcggc
     6301 ggggccgcgc ccggctgcgg atcccggggc gcggcctgcg ctcgctggcc cgcatgcagc
     6361 tggagatggc gggtatcgcc cgtgaacgcc gccgcgtccc ggcggacgac gtgatctcgg
     6421 cactcgtccg cgcggacgtc ggcggacagg cgctgtcctc gcgtcagctc ggcgcgttct
     6481 tctcgctgct gctcgtggcc ggtgtggaga ccacgcggaa cgcgatcgcc cacgggctgg
     6541 tcctgctgac ggagcatccg gagcagcggg cgctcctgga gtccgacttc gaccgttacg
     6601 ccgacggcgc ggtggaggag atcgtgcggc actcgacgcc gatcatccag ttccgccgga
     6661 cggtggcggc ggagtgcgcg ctcggcggcc gcacctttct gcccggggag aaggtcgtgc
     6721 tcctctacgc gtccgcgaac cgcgacgcct cggtgttcga cgacccggac gcgttcgaca
     6781 tcacccggtc gcccaatcca catctcgggt acggcggcgg gggccctcac cactgtctgg
     6841 gagcacatct cgcgaagctg gagctgaaag cgctcttccg cgaaatgctc acccggccgg
     6901 tgaatatccg ggcctcagga gaacccggtc tggtcgattc gaatttcgac aaccgtgtcg
     6961 gctctcttcc cttcatcttc gaccggagtc acccgaacgg tccgctatga acggacgcgt
     7021 gtcgcgaatg ggctattcac gcgcggtccc gcagcccatt gttgaatctt tctccttagg
     7081 gtcggcaggg tcggagtaag gccgcaatcc aaggaggagc cgtgcccgta cagcgccgtc
     7141 tcaccaattt cggcgtcggc gcgaccgcgc tctgcctcct cgtcggcggc gcggtcctcg
     7201 ccgatcgcga cgcggaggac acccaggccg gtaagggcgc ggctcagcag gcccccgagc
     7261 cggggacgac gaccgccatc ggcgcctacc tggactacgg gccgaagggc gtccagcgga
     7321 tgggagagct ctcccgctgg ctcggcggta cggagatgcg cgtcgggcac agctatctgc
     7381 cgggcgacct gtgggagaac atcgagggcc gccccgggtt cctcgcctcc tgggctgcct
     7441 ggcgcaaggc ggcggacgac cggatgttcg tcctcaacac accgatgctg gagcgcaacg
     7501 aggagcatgt ctccgacgac gaggtgcgcg gtctgctgcg ggacggcgcc gagggccggt
     7561 tcgacgagca cttccgccgc ctggccgagc gcctggtgct gctgggcgta ccggacaccg
     7621 tgatcgtcct cggctgggag atgaacggga cgacgtacac gcaccggtgc ggtcccgacc
     7681 ccgtcgcctg gaaggcgtac tggaaccgta tcgtcaccac gatgcggtcc gtgtccggcc
     7741 aggagttccg tttcgacttc gcgccgagca gggggcggga cgccgtgccc tggacggagt
     7801 gctacccggg cgacgacgtc gtggacatca tcggcatgga ctcctacgac cagcctccgg
     7861 cgcgggactt cgacgagcag gtgaacgaac cgtacggcct tcagaagcag gtcgacttcg
     7921 ccgcggagca cggcaagccg atctcgttcc cggagtgggg gctgttccgc aacggcgaca
     7981 accccgagta catgcgccgg atgctggagt ggatcgagca gcacaagccg gtgtaccaga
     8041 cgatcacgga ctactgtccg cacggggtgt ggcagtgctc cgagaacccc gagtcctccc
     8101 gggtcttccg tgagatgctg agcggcctgc cgaacgccac ggagccctcg gcgcccgctg
     8161 ccgacccgag cgggacaccg acggcgccca agccggacaa gcccacgccg acggtgccca
     8221 cgccggacac caacggctcc gggtggtgct tcaccgtccc gctgagcgac tggttcggcc
     8281 agtggctgag cgaccgcgag ttctgcgtac gcggctgagg gacctgagga gcgcggcatg
     8341 cgggtggcgg tggcgggcgg aaccggggtg gtcgggcggc tcgtcgtcgg ggaactggcc
     8401 gcggcgggac acgaaccggt tgtgctggca cggtcgcacg gtgtggagtc gtctccggcg
     8461 agggcctcga cgcggccctc gacggcgtgg aggcggtcat cgacgtgagc gacaggaagg
     8521 cggtcagccg gggcagggcg gtcgcgttct tcggctcggt cagccgcaat ctgctggacg
     8581 cgggtgcgcg cgccggggtg caccaccatg tggcgctgtc gatcgtcggt atcgaccggg
     8641 tcgggcacgg ctactaccag ggcaagctcc gccaggagga ggtcgtcagg ggcgggcggg
     8701 tgccgtggac cgtgctgcgg tccacgcagt tccacgagtt cgtgtcccag gccctccagc
     8761 agatgccggg accggtcgcg gtggtgcccc ggatgaacat ccagccggtc gcggcgcgtg
     8821 aggtggcgcg gcacctggtg gagctggcgc tcgccccgcc gcggggcatg gctccggagc
     8881 tcgcgggacc gcgggtggaa ctgctcgtcg acctggtacg gcggctgctc cacgcccgcc
     8941 acgagcgcag gctggtggtg ccggtgaggc tgccgggcgc cgtgggggcc gccatggcgg
     9001 gcgacggcca gctgccggcc ggcgcggggc cccggggcag ccggacgttc gacgagtggc
     9061 tcgccggtgc ggtcacccgg ggagcctgac gggaccttgt caccgcaccg agcctccgcc
     9121 gtcgctcacc acccggtcca cagcagatgg ttgaccagca gggcgacgac ggcctgggcg
     9181 gcgagccagc cgcgccggcc ggggccggga agcagggcgg cggcgggcat cagccagacg
     9241 acgaacggct gccagatgcg ttccgtctcc gccttgctca tcccggacag atccgcgacg
     9301 gccagggcca ggagcgcggc gagggtgagg agcgcgagcc gctgagccgc cgtggtggtt
     9361 cccggacgca ctccgcgtac ggcggcgggg gcggacaccg ccgcgcgtcg cagacccgcg
     9421 acggtggcga ggcccgcggc gagtgtggtg caggcgaggt tcgcccagac ccagtaggag
     9481 taggggcggg tgccgcccgc gccctggtag tagcgctcga ccagcaggtg gtaggcctcc
     9541 caccagctga agcccgccag ggtgaaggcc acgggtgcga ccagggcgcc gagggcgagg
     9601 ggggcgagcg gacgtgccgt ccgggtcagc aggaggacgg cccccagcag gaccgcgatg
     9661 agcgtcagac cgtaactgag gtagcaggtc agcccgaaca gcaggcccga gcccagcgcg
     9721 gttgccccgg ggtgcctggc cgtgcgggtc gcggcgaggg ccagcagtgc cacggaccac
     9781 gccgcgacgg cggcgaagta gccgtccgcg gaggtgccgg tccagacggc gaagggggcg
     9841 aggacgagga acggagccgc gcgccgggcg aggtgctcgt ccgtcagggc gcgcagcgcg
     9901 accaggacgg ccaccgcggc cgagccgccg agcacgatgc accacatgcc cgcccaggcg
     9961 ccgcccccga gtccggcccg gtccaggccg acgaaggtga gtgtggcgcc cggcgggtga
    10021 cccgcgacgt gggcgggcca gttgcccggc gggccgatga cgatgtggtc cgtgaacccg
    10081 cgcagggcgg cgccgatgtc gtcgaaccgg tcgatcacgc gcaggtattc gtgcttggtg
    10141 gtcagcctgc gcgcgatccc ccggtaccag ccctcgatga gggcgagcga gaggatccac
    10201 gccaccgagc cggcccagca cgtgagcagc agccgcctcc aggggagccg cgcggccagc
    10261 cgtggcccgt aggcgacgac cgccaccgcc accgccacgg cggccggggt gccggggccg
    10321 agatgcgggt cccaggaggc caggaggggt ggccactgga cctgaaggct gccgtcgccc
    10381 tgctggatca cccagccgat ccctatggcc gcggccacca gcagaacccc cgccgccgcg
    10441 gccgtcaggt cccggcggcg gccggccggt tcgtcggtgc gggcgggctc gggg
//
