LOCUS NZ_RDBM01000011 10228 bp DNA linear CON 01-JAN-2025 DEFINITION Streptomyces sp. gb1(2016) Scaffold_11, whole genome shotgun sequence. ACCESSION NZ_RDBM01000011 VERSION NZ_RDBM01000011.1 KEYWORDS WGS; RefSeq. SOURCE Streptomyces sp. gb1(2016) ORGANISM Streptomyces sp. gb1(2016) Bacteria; Bacillati; Actinomycetota; Actinomycetes; Kitasatosporales; Streptomycetaceae; Streptomyces. REFERENCE 1 (bases 1 to 259573) AUTHORS Hariharan,J., Choudoir,M.J., Diebold,P., Panke-Buisse,K., Campbell,A.N. and Buckley,D.H. TITLE Direct Submission JOURNAL Submitted (16-OCT-2018) Soil and Crop Sciences, Cornell University, 306 Tower Road, Ithaca, NY 14850, USA COMMENT ##Genome-Assembly-Data-START## Assembly Date :: 2018 Assembly Method :: A5+MeDuSa v. JUNE-2018 Genome Representation :: Full Expected Final Version :: Yes Genome Coverage :: 66x Sequencing Technology :: Illumina MiSeq ##Genome-Assembly-Data-END## ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Name :: GCF_008042065.1-RS_2025_01_01 Annotation Date :: 01/01/2025 02:23:01 Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline (PGAP) Annotation Method :: Best-placed reference protein set; GeneMarkS-2+ Annotation Software revision :: 6.9 Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA Genes (total) :: 7,414 CDSs (total) :: 7,333 Genes (coding) :: 6,887 CDSs (with protein) :: 6,887 Genes (RNA) :: 81 rRNAs :: 6, 1, 2 (5S, 16S, 23S) complete rRNAs :: 6, 1, 1 (5S, 16S, 23S) partial rRNAs :: 1 (23S) tRNAs :: 69 ncRNAs :: 3 Pseudo Genes (total) :: 447 CDSs (without protein) :: 446 Pseudo Genes (ambiguous residues) :: 0 of 447 Pseudo Genes (frameshifted) :: 94 of 447 Pseudo Genes (incomplete) :: 395 of 447 Pseudo Genes (internal stop) :: 7 of 447 Pseudo Genes (multiple problems) :: 48 of 447 ##Genome-Annotation-Data-END## ##antiSMASH-Data-START## Version :: 8.dev-cf2fc5ee(changed) Run date :: 2025-09-13 13:17:57 NOTE :: This is a single region extracted from a larger record! Orig. start :: 236398 Orig. end :: 246626 ##antiSMASH-Data-END## REFSEQ INFORMATION: The reference sequence is identical to RDBM01000011.1. The annotation was added by the NCBI Prokaryotic Genome Annotation Pipeline (PGAP). Information about PGAP can be found here: https://www.ncbi.nlm.nih.gov/genome/annotation_prok/ FEATURES Location/Qualifiers region 1..10228 /candidate_cluster_numbers="1" /contig_edge="True" /product="RiPP-like" /region_number="3" /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))" /tool="antismash" cand_cluster 1..10228 /candidate_cluster_number="1" /contig_edge="True" /detection_rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))" /kind="single" /product="RiPP-like" /protoclusters="1" /tool="antismash" protocluster 1..10228 /aStool="rule-based-clusters" /category="RiPP" /contig_edge="True" /core_location="[5000:5228](-)" /cutoff="20000" /detection_rule="(strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))" /neighbourhood="5000" /product="RiPP-like" /protocluster_number="1" /tool="antismash" proto_core complement(5001..5228) /aStool="rule-based-clusters" /tool="antismash" /cutoff="20000" /detection_rule="(strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))" /neighbourhood="5000" /product="RiPP-like" /protocluster_number="1" misc_feature 466..475 /note="TFBS match to AbrC3, Antibiotic production activator, confidence: strong, score: 18.16" /tool="antismash" misc_feature complement(591..603) /note="TFBS match to MatP, Cell cycle regulator, confidence: weak, score: 20.33" /tool="antismash" misc_feature 725..740 /note="TFBS match to LexA_variant_1, Repressor of DNA damage response, confidence: weak, score: 19.99" /tool="antismash" misc_feature complement(1523..1536) /note="TFBS match to BldD, Development and antibiotic global regulator, confidence: weak, score: 19.64" /tool="antismash" gene complement(1841..4114) /locus_tag="EAO74_RS04130" /old_locus_tag="EAO74_04130" CDS complement(1841..4114) /GO_function="GO:0005524 - ATP binding [Evidence IEA]" /GO_function="GO:0008233 - peptidase activity [Evidence IEA]" /GO_function="GO:0140359 - ABC-type transporter activity [Evidence IEA]" /GO_process="GO:0006508 - proteolysis [Evidence IEA]" /GO_process="GO:0055085 - transmembrane transport [Evidence IEA]" /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) Peptidase_C39" /gene_functions="transport (smcogs) SMCOG1288: ABC transporter related protein" /gene_kind="transport" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_014157698.1" /locus_tag="EAO74_RS04130" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="EAO74_04130" /product="NHLP family bacteriocin export ABC transporter peptidase/permease/ATPase subunit" /protein_id="WP_147982689.1" /sec_met_domain="Peptidase_C39 (E-value: 2.8e-38, bitscore: 124.7, seeds: 36, tool: rule-based-clusters)" /transl_table=11 /translation="MTAPHPSPAAQQLPPPGRGRHRPEGAPGNRRRSRPAPKPKRTRSV HTPTVLQMEALECGAASLAMVLGHYGRHVPLEELRIACGVSRDGSRASNVLKAARSYGL QAKGMQMEPAALAEVQAPAILFWEFNHYVVYDGVGRRLGRRGVHINDPDKGRRFVPAED FDTSFTGVVLVLEPGEDFERGGRKPGVMSALPARLRGTTGTMLVALLASLLLVAVGATL PALSRTYIDMFMIGEQTSLLGVLFAAMGTMVALTVVLTWLQQANLLRGRIISSTLGSAR FFRHLLRLPVTFFSQRSPADLVQRLQSNDAVAETLARDLTAAGVDGIVVLLYAFLLWTY DPQLTVIGVGIALLNVVAMRIVVRLRATGTQKLRADSARLTNTSYTGLQLIETMKATGG ENGYFRRWAGQHATTLDEQQRLGVPSAWLGIVAPALATLNSALILWIGGLRAVEGHISI GLLVAFQALVTRFTAPLTRLNGVAGRVQDFAADVARLKDVESFPVDPLYSRREPAASTR RLKGHVTLEDITFGYSPLDKPLLTGFSLSVGPGQQVALVGGSGSGKSTVSRLISGLYSP WEGTIRIDGRRLEDIPRGALAASVSFVDQDVFLFEGTVRDNVALWDPSVPDEAVTEALR DAALYDVVARRPRGIHSRVEQDGRNFSGGQRQRLEIARALVRRPSILVLDEVTSALDAE TERIIIDNLRRRGCACVVIAHRLSTVRDSDEIVVLDHGTVVERGRHENLVAAGGAYADL VREH" gene complement(4111..4917) /locus_tag="EAO74_RS04135" /old_locus_tag="EAO74_04135" CDS complement(4111..4917) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007386622.1" /locus_tag="EAO74_RS04135" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="EAO74_04135" /product="HlyD family efflux transporter periplasmic adaptor subunit" /protein_id="WP_124278435.1" /transl_table=11 /translation="MQFRQQALSKLQSPEQLDLPVRFARPQGLLVLVVTVAVMAAACVW AVTGSVASTLDAPGILTHSRGSYILQSPVAGQITEVLAEEGQTLPRNSPLLKVRTEQGE RVVRTIDAGRLTSVTATIGAVVTTGADVASVERIDGPDDPLVVLLYVSGSSAASVPVGA SVDLTVQSVPAQQYGVLRGKVAAVGRAAQTQQQITRFLGDAQLGEQFSKHGRPLAVLVK IERSSATESGYRWSSADGPPYAIGSMTLATGSVRLADQRPIDWLLP" gene complement(5001..5228) /locus_tag="EAO74_RS04140" /old_locus_tag="EAO74_04140" CDS complement(5001..5228) /codon_start=1 /gene_functions="biosynthetic (rule-based-clusters) RiPP-like: strepbact" /gene_kind="biosynthetic" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_014157700.1" /locus_tag="EAO74_RS04140" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="EAO74_04140" /product="type A2 lantipeptide" /protein_id="WP_099171946.1" /sec_met_domain="strepbact (E-value: 6.9e-34, bitscore: 110.2, seeds: 15, tool: rule-based-clusters)" /transl_table=11 /translation="MNYTPQVETAEISDSDLDNVSGGLVGGLVGNATSTVEGIVPVSGV VGSVTGLVESATGVNTGAVTGLASGLTAGL" misc_feature complement(5320..5335) /note="TFBS match to LexA_variant_1, Repressor of DNA damage response, confidence: weak, score: 21.69" /tool="antismash" misc_feature complement(5497..5512) /note="TFBS match to DasR, N-acetylglucosamine dependent repressor, confidence: weak, score: 19.54" /tool="antismash" misc_feature complement(5923..5937) /note="TFBS match to CelR, Cellobiose uptake repressor, confidence: strong, score: 28.15" /tool="antismash" misc_feature 5924..5938 /note="TFBS match to CelR, Cellobiose uptake repressor, confidence: strong, score: 30.11" /tool="antismash" gene 5996..8710 /locus_tag="EAO74_RS04145" /old_locus_tag="EAO74_04145" CDS 5996..8710 /GO_function="GO:0004553 - hydrolase activity, hydrolyzing O-glycosyl compounds [Evidence IEA]" /GO_function="GO:0030246 - carbohydrate binding [Evidence IEA]" /GO_process="GO:0005975 - carbohydrate metabolic process [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_014157701.1" /locus_tag="EAO74_RS04145" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="EAO74_04145" /product="cellulose binding domain-containing protein" /protein_id="WP_410089240.1" /transl_table=11 /translation="MRLSARPIAALVAALALTAGLSITGTPAVARPDDRAAAAEASDVS IAADTYTWKNARIDGGGFVPGIVFNRSEKDLAYARTDIGGAYRWDQAGKRWTPLLDWVD WDRWGWSGVVSLASDTAEPDNVYAAVGTYTNSWDPTNGAVLRSSDRGASWKAATLPFKL GGNMPGRGMGERLAVDPNKNSVLYLGAPSGNGLWRSADSGVTWSEVTAFPNPGNYAQDP SDTSGYGNDNQGIVWVTFDERSGSADSATQDIYVGVADKENTVYRSTDGGSTWSRIAGQ PTGYLAHKGVLDSSTGHLYLTLSDTGGPYDGAKGRIWRYDTESGAWTDVSPVAEADTYY GFGGISVDRQKPGTLMATAYSSWWPDTQIFRSTDSGATWTQAWDYSSYPNRSNRYTLDV SSVPWLSWGANPTPPETAPKLGWMTESLEIDPFDSDRMMYGTGATVYGTENLTSWDSGG TFTITPMVKGLEETAVNDLASPPSGAPLLSALGDIGGFRHTDLDAVPAMMFTSPNLDST TSLDFAEASPGTVVRAGNADAAPHIGFSTDNGANWFQGSEPSGVTGGGTVAAAADGSGF VWSPEGAGVHHTTGYGTSWNASTGIPAGATVESDRKNPKKFYGFSAGTFYVSTDGGATF TAKATGLPAEGNVRFKALPGTEGDIWLAGGAPTGAYGLWRSTDSGASFTRLSGVEQADS VGFGKAASGAPYQTVYVSAKIGGVRGIFRSTDAGAGWTRINDDAHQWAWTGAAITGDPR VYGRVYVSTNGRGIQVGESSDTDGPGTDPGPGTDPGTDPGEPPADADCSVAYTVTNRWS GGFQAEVKLTNTGTAAYDGWKLGWTFPGDQRIGQIWNASHQQTGAKVTVTDAGWNGKVA PGSSAAFGFTGTTTGDGTAPGAFTLGGEACAVG" misc_feature 6056..6058 /note="tta leucine codon, possible target for bldA regulation" /tool="antismash" ORIGIN 1 gctgcgcgcg aactccgccg cccatgcccc gtacgcgaag ctctccgccg cggcgacccg 61 cagcttgggc agtccgcgca gtgtctggaa ggcctggttg ttgagcttgt tgcccagcac 121 caccagccgg cgctgccagc ggagctccca catgcccatg gtgaggaaca ccccggcgat 181 gaccaccagc atggcgaccg cggtgagggc cagcggaacg ctgaaccaga gcagcaggcc 241 cagattcatc gcccccagcg tgcccgcctg caccaccacg ggaccggtgc cggacagcac 301 ccggcggatc gcgctcaccc ccatcgccgc gctcgccagc tcacccgtgg agcgcccggt 361 gaagaacttc gtcggcagcc gcagcagccg gtcccacacc gcgggctgga gcgtgctctc 421 gatccgcccc tccatccgca ggatggtgag gttctgcagc agcatgaagg cggccgagac 481 gaccccggag atgatgaccg ccagcgacgc ctgcacgatg agcgcgttct gggcgttggg 541 cacgtacacg ccgagcacct tgccggtcgc gatcggcacc agcgagccca gtgccaccgt 601 caccaggccc gcgggcacca gcctccgcag atcgccccgg gtgccgaaga ggccgaagcg 661 cagcaactgc cacttgccca gcgggcgttc gggcagcggg cggtagaaca tcacggcgcg 721 ctcgtcgaac tcctgcgcgg atgcgctgtc gacacggctg cgccggccgg tcagcgggtt 781 gaccgcctcg tagcggccac ggcgccagag cagggccacc ggtgccccgg acgcggtgcg 841 gtgacccacc agcggaccgg agttctcccg ccaccagcgc cccgcgagcc gcaccgggcg 901 ggtgcggatg cgcgaggcga ccgcgacacg ctcgaccggg tcgatccggt cgctcaccgc 961 cccgcccgtg gccggttcgg cgaggacgat cccggagtcc ctggccacca ggaggcaggc 1021 cgcgtacacc gcgtcgtccg agccccccga cgccggcgag gcgcccctgc cggaccggcc 1081 gatcgaggtc agcagcgcct ggtcggcctc cttgcggacg gcctcgcccg ccttcatgcc 1141 cgccgcggtg cggtcctcgt gggcgcgctc cagctgctcg atccagcggt ccagcgccga 1201 cagcaggcgg tactgctgat tgaccatccc ctgccacatc gccgggtcga cgagcaggtc 1261 acccgccgcc tcggcgctga acgcggcgcc gtactgcaca ctgcccggtg agaccggcag 1321 ccacaggatg tcgtcgtcgc ccaccgtccc gtcgaaggtg gtccgcccgt ccagcggggc 1381 ctcgaacagc acccgctggc tccggcccac gcccagcgag aaggcgtgct ccagcaagct 1441 cagcgcagcg tccccggtgt cgtagtgact gcggtactgc ccctcgtacg ccccctggcc 1501 ggcgtactcc ggccggtaca gctcacgcag cgggatccgg cgcagcacgc actcctggag 1561 ggggcggccc accagggtgt gctgcgggcc ctcgaccggg cccaggacga gcgtccccgg 1621 ttcgagccgg cccaggaagt gccagtgccc ctgctccacc gcgtccaccg cgaacaggtc 1681 gagggcgccg cccacgacga gccacagcac ctgggggccc tccagcgaca ggctccgcag 1741 accggtgcag tccacgggct caccgagggc tcccagcgct ccgatgaccg ggtcctgccc 1801 gggcgcctcc gtgcccgcga ggggatgtgt ggatgccacg tcagtgctcc ctgaccagat 1861 cggcgtacgc gcccccggcg gccaccaggt tctcgtgccg gccgcgttcc acgaccgtgc 1921 cgtggtccag gaccacgatc tcgtcgctgt cgcgcaccgt gctcagccgg tgggcgatca 1981 cgacacaggc gcagccgcgc cggcgcaggt tgtcgatgat gatccgttcc gtctcggcgt 2041 ccagcgcact ggtgacctcg tccaggacca ggatgctggg gcggcgtacg agcgcgcggg 2101 cgatctccag gcgctgacgc tgcccgccgg agaagttccg gccgtcctgc tccacccggc 2161 tgtggatccc gcggggccgg cgggcgacga cgtcgtacag ggcggcgtcc cgcagggcct 2221 cggtcaccgc ctcgtccggg accgagggat cccagagcgc cacgttgtcc cgcaccgtcc 2281 cctcgaagag gaagacgtcc tggtcgacga aggacaccga cgcggccagc gcgccccggg 2341 gtatgtcctc caggcgccgg ccgtcgatac ggatcgtgcc ctcccacggg ctgtagagcc 2401 ccgagatgag ccgggagacc gtcgacttgc cgctgcccga accgccgacg agtgccacct 2461 gctgccccgg ccccaccgac agcgagaaac cggtgagcag cggcttgtcg agcgggctgt 2521 agccgaaggt gatgtcctcc agcgtcacat ggcccttgag ccgccgggtg ctcgcggccg 2581 gttcccggcg cgagtacagc ggatcgaccg ggaagctctc cacgtccttg agacgggcca 2641 cgtcggccgc gaagtcctgc acccggcccg ccaccccgtt gagccgggtc agcggcgcgg 2701 tgaaccgggt caccaacgcc tggaaggcga cgagcagacc gatcgagatg tgcccctcga 2761 cggcccgcag cccgccgatc cacaggatca gtgcgctgtt gagcgtcgcc agggcggggg 2821 cgacgatgcc cagccaggcg ctcggcaccc cgagccgctg ctgctcgtcc agcgtcgtcg 2881 cgtgctgtcc ggcccaccgc cggaagtagc cgttctcgcc cccggtcgcc ttcatcgtct 2941 cgatcagctg gagaccggtg tacgaggtgt tcgtcagccg tgcgctgtcg gcccgcagct 3001 tctgggtgcc ggtggcccgc agccgtacga cgatgcgcat cgcgacgacg ttgagcagcg 3061 cgatgcccac cccgatgacg gtcagctgcg gatcgtaggt ccacagcagg aaggcgtaga 3121 ggaggacgac gatgccgtcc acgccggccg cggtgagatc ccgggcgagg gtctcggcga 3181 cggcgtcgtt ggactggagg cgctggacga ggtcggcggg gctgcgctgg gagaagaagg 3241 tgacgggcag ccggagcaga tgccggaaga agcgcgcgct gccgagcgtg gacgagatga 3301 tccgcccgcg cagcagattc gcctgctgaa gccaggtcag gacgaccgtg agcgcgacca 3361 tcgtgcccat cgcggcgaac agcacgccca gcagcgaggt ctgctcgccg atcatgaaca 3421 tgtcgatgta ggtacggctc agggccggga gcgtcgcccc gacggccacc agcagcaggc 3481 tggcgagcag cgcgaccagc atcgtgcctg tggtgccgcg cagccgggcc ggcagcgcgg 3541 acatgacgcc gggcttacgg ccgccgcgct cgaagtcctc gccgggttcg aggacgagga 3601 cgaccccggt gaagctggtg tcgaaatcct cggcgggcac gaaccggcgg cccttgtcgg 3661 ggtcgttgat gtgcaccccc cgccgtccga ggcgacgccc cacaccgtcg tacacgacgt 3721 agtggttgaa ctcccagaac aggatcgcgg gcgcctggac ctccgcgagg gccgcgggct 3781 ccatctgcat gcccttggcc tggagaccgt aactgcgggc tgctttcagt acgttgctgg 3841 cccgtgagcc gtcgcgcgag acgccgcagg cgatccgcag ctcctccagc ggcacatggc 3901 ggccgtagtg gccgagcacc atcgccagcg aggcggcacc gcactccagg gcctccatct 3961 ggagcaccgt gggggtgtgc acgctcctcg tccgcttggg cttcggcgcc ggacgcgacc 4021 gccgcctgtt gcccggggcg ccctccgggc ggtgcctgcc gcggccgggc ggcggcagct 4081 gctgggcggc gggggacgga tgcggtgcgg tcacgggagc agccaatcga tcgggcgctg 4141 gtcggcgaga cggacggagc cggtggccag ggtcatggag ccgatcgcgt acggggggcc 4201 gtcggcggag gaccagcggt agccggactc cgtggcggac gagcgttcga tcttcaccag 4261 gaccgccagt ggccgcccgt gcttcgagaa ctgctcgccg agctgggcgt cgccgaggaa 4321 gcgggtgatc tgctgctgtg tctgcgccgc ccggccgacg gcggccacct tgccgcgcag 4381 caccccgtac tgctgggcgg gcacggactg gacggtgagg tcgacggagg cgcccaccgg 4441 gaccgacgcg gcactgctgc cggacacgta gagcaggacg accagcgggt cgtcggggcc 4501 gtcgatccgc tcgacgctcg ccacgtccgc gccggtggtg accacggcgc cgatcgtggc 4561 ggtgaccgag gtgagccggc ccgcgtcgat ggtgcggacg acgcgttcac cttgctccgt 4621 acggaccttg agcagagggg agttgcgggg gagggtctga ccctcctcgg cgagcacctc 4681 ggtgatctgc ccggccaccg ggctctgcag gatgtaactg ccgcgggagt gcgtgaggat 4741 gccgggggcg tccagggtgc tcgcgacgga gcccgtcacg gcccagacgc aggcggcggc 4801 catcacggcg acggtgacga cgaggacgag caggccctgc ggtcgggcga agcgcaccgg 4861 cagatcgagc tgttcgggcg actgcagctt ggaaagggcc tgctggcgga actgcacgga 4921 actcttgcct cacctgtcag cggtcggcac cgagccccgg aaccgacggg ttccggggct 4981 cggtggggtc ctgccgtgtc tcagagaccg gcggtcaggc cggaggccag gccggtgacc 5041 gcgcccgtgt tcacgccggt ggcggactcg acgagaccgg tgaccgagcc gacgacgccg 5101 gagaccggga cgatgccctc gacggtgctc gtggcgttgc cgacgaggcc gccgacgagg 5161 ccgcccgaga cgttgtcgag gtcgctgtcg gagatctcgg cggtctcgac ctggggggtg 5221 tagttcatga tgagcgctgc ccttcgtatg gaaattgcct atatacggaa acccgtggtg 5281 cgacctccgt atgggccagg atcaaagcac gcctgcgcct cgtacagcca atcgaactgc 5341 ggcggatctg tggttatcgg gccgctggaa tcgacgtacg tgcagaagtg ttcatttcgt 5401 ggcggcagat ccttcacgag cttcaccgga tgaattccgt gtcggcgcaa cttcacgccc 5461 cccaagtagg gcactcccgc cccaatcgcc ccacggaccg gtctggacct ggccttctgt 5521 cccgagtcgc gtgatcggtg tgcgcacgcc gtgtgcaggt tttttcgata cgggggcgca 5581 tccgcaattc cgggcgccgg agccgcacgg ctccgcagga ggttcggcgg ctatcggtat 5641 tcacgctacc gtgaaagatg aacacggctc tcttttctcc gtgttccgtc tgcgaatgga 5701 cggcgccttt atgaagcact ttccgggtat gcgtgttcac cgtgtcacct ggtctccggg 5761 tatatggaga agatgtgccg ccttctgtgg gcgcggtgga cggtgtgggc gtccgtgcgg 5821 ccgggccggc ggcggcgtgc ggtgctcggc ccgattcatc cgatgaaacg actgcaccac 5881 ccttctgtgg ggcgacgcgc ggcgctacca tcgggatgcc ttttgggagc gctcccatct 5941 cttgtcggcc ccgtaccgcc cctcaggggc ggaccagctc ggagaggacg tttccgtgcg 6001 cctgagcgcc agaccgatcg ccgccctcgt ggcggcactt gccctcaccg ccgggttatc 6061 gatcaccgga accccggccg tggcacgccc cgacgacagg gccgccgcgg ccgaagcatc 6121 ggatgtgtcc atcgcggcgg acacgtacac atggaagaac gcccggatcg acggcggcgg 6181 ctttgtgccg ggcatcgtct tcaaccggtc ggagaaggac ctcgcctacg cgcgcaccga 6241 catcggcggc gcctaccgct gggaccaggc gggcaagcgg tggacgccgc tgctggactg 6301 ggtggactgg gaccggtggg gctggtccgg ggtggtgagc ctcgcctccg acaccgccga 6361 gccggacaac gtgtacgccg ccgtcggcac gtacaccaac agctgggacc cgacgaacgg 6421 ggcggtcctg cgttcctcgg accgcggtgc ctcctggaag gcggccacgc tgcccttcaa 6481 gctcggcggc aacatgccgg gacgagggat gggggagcgg ctcgcggtcg acccgaacaa 6541 gaactccgtg ctgtacctcg gcgctcccag cggcaacggg ctgtggcgtt cggccgactc 6601 gggggtcacc tggtcggagg tgaccgcctt ccccaacccc gggaactacg cgcaggatcc 6661 gtccgacacc agcggatacg gcaacgacaa ccagggcatc gtgtgggtca ccttcgacga 6721 acgctccggc agcgcggaca gcgccacgca ggacatctac gtcggggtcg ccgacaagga 6781 gaacaccgtc taccgctcca cggacggcgg ttccacctgg tccaggatcg ccggccagcc 6841 gaccggctac ctcgcgcaca agggcgtact cgactcctcg acgggccacc tctatctgac 6901 gctgagtgac acgggcggcc cctacgacgg tgccaagggc cggatctggc gctacgacac 6961 ggagtcgggc gcctggacgg acgtcagccc cgtcgcggag gccgacacct actacggctt 7021 cggcggcatc tccgtcgacc ggcagaagcc cggcaccctg atggcgaccg cgtacagctc 7081 gtggtggccc gacacccaga tcttccgctc caccgacagc ggcgccacat ggacccaggc 7141 ttgggactac agcagctatc cgaaccgctc caaccggtac acgctggacg tctcctccgt 7201 gccctggctc agctggggcg cgaaccccac cccgccggag acagcgccca agctgggctg 7261 gatgacggag tccctggaga tcgacccctt cgactcggac cggatgatgt acggcacggg 7321 agccacggtc tacggcaccg agaacctcac gtcctgggac tccggcggca cgttcacgat 7381 cacgcccatg gtcaagggcc tggaggagac cgccgtcaac gacctggcga gcccgccctc 7441 gggcgcgccc ctgctgagcg cgctcggtga catcgggggc ttccggcaca ccgacctcga 7501 cgcggtgccc gccatgatgt tcacctcgcc gaacctggac tcgaccacca gcctggactt 7561 cgccgaggcg tcccccggca cggtcgtacg ggccggcaac gcggacgccg ctccgcacat 7621 cggcttctcc accgacaacg gcgccaactg gttccaggga tcggagcctt ccggtgtcac 7681 gggcgggggc acggtcgccg ccgcggcgga cggcagcgga ttcgtctgga gcccggaggg 7741 cgcgggcgtc caccacacca ccggctacgg cacctcctgg aacgcctcca ccgggatccc 7801 cgccggggcg acggtcgagt cggaccggaa gaacccgaag aagttctacg ggttcagcgc 7861 cggcaccttc tacgtgtcga ccgacggcgg cgccacgttc accgcgaagg cgaccggact 7921 cccggccgag ggcaacgtcc gcttcaaggc gctgcccggc acggagggcg acatctggct 7981 cgcgggcggc gctccgacgg gtgcgtacgg gctctggcgc tccaccgact ccggcgcgag 8041 cttcaccagg ctctccgggg tggagcaggc cgacagcgtc ggcttcggca aggcggcctc 8101 cggggccccg taccagaccg tctacgtcag cgcgaagatc ggcggggtgc gcggcatctt 8161 ccggtccacg gacgccggcg ccggctggac acggatcaac gacgacgcgc accagtgggc 8221 ctggacgggc gcggcgatca ccggggaccc gcgggtctac ggccgcgtgt acgtctccac 8281 gaacggccgg gggatccagg tcggcgagtc ctcggacacc gacggcccgg gcacggaccc 8341 gggccccggc accgaccccg gcaccgatcc gggggagccg ccggcggacg cggactgctc 8401 ggtggcgtac acggtcacca accggtggtc cggcggcttc caggccgagg tgaagctcac 8461 caacaccggc accgccgcct acgacggctg gaagctgggc tggaccttcc ccggtgacca 8521 gaggatcggt cagatctgga acgcctccca ccagcagacc ggtgcgaagg tgaccgtcac 8581 cgacgccggc tggaacggga aggtggcccc cggctcctcg gccgccttcg gcttcaccgg 8641 tacgacgacg ggcgacggca ccgcgcccgg cgcgttcacg ctgggcggtg aggcctgcgc 8701 cgtcggctga ccccctgccg ggcaggtgcg ggagtgccgg ccccgcgggc cgccaaatgg 8761 acataccgcc cggggcgtgc tgcattggag tgaacgcacc acgccctggg aggtaccccg 8821 tggccgacgt cgacgtgctg atcgcggggg cgggccccgt cggcctgaca gccgcctccg 8881 agctgtgccg ccgcggcgtg gcgtgccggg tcgtcgaccg gctcccggag aggctcccct 8941 tcgcacgtgc cgtgggcgtc cagccgcgga cgctggagat ctgggatcgg atggggatga 9001 tccgggaggc gctggagacg gccgtcccgt tgaagggcca gttgctgtac gtcaacggtg 9061 aggagggccc gcggatcgac ctcgcactgc cgcccgaggt gccgtaccgc ttcgcggcac 9121 tcccgcagta cgagaccgag cgcctcctgg aggacctcct ccgccgctgc gggggcgagg 9181 tcgaacgcgg caccgcactc gtctccttcg cgcaggaccc ccacgtggtg agagccgtcc 9241 tctccctgcc cacgggcggc accgaggaac tgacggcccg ctacctcatc ggctgcgacg 9301 gcgcccacag cgtggtccgc aaggggctgg gcctgtcctt cgaaggcgcg gcgctccccg 9361 aggagtacat gctgggcgac gtcgaggtcg actgggatct gccggccgga tacgcggtcc 9421 ggtcctcgaa cgtcgtcgac gggctcaccg acgacctgtt ggtgtgcatc ccgctgcccg 9481 gcgaccaccg ctaccggatg tccatggcga cccctcccga actgtcccgt gcggggcaga 9541 aggacgcgga cggtgtcacg cacggcctga gcggggaaca ggggcccgtg cccggcctcg 9601 aacacatcca ggccgtgctc gaccggctct ccccgcgccc cacgaccgcg acctccctgc 9661 gctggtcctc cgtgttccgc atcagccacc gcatcgtcga ccggtacggg cacgggaggg 9721 tcttcgtggc cggggacgcc gcgcacatcc acccgcccac cggcgcccag gggatgaaca 9781 ccggcgtcca ggacgcgtac aacctggcct ggaaggtcgc cgcggccgtg cgcggccacg 9841 cgggtgccgg gctgctggag agctacgacg ccgaacgccg gccgatcggt gaggaagtgg 9901 tggaccgcac gctgcgccac gcgaggagcg gcatccaggc cgaccccgac gacccggcga 9961 ccacgatgct ccgtgaagcc cagctcctcc tcggctaccg gggcagcgcg atcgtgggac 10021 cggtcggctc cgcgcacgac ggcccggaac cgggcgaccg ggcgcccgac tgcggaggcc 10081 tcctgtacgc cctgagggcc ttccccgtcc ggctgttcag cctgctgcgg gagcgcgagc 10141 acaccctgct cctctacgcc gaccacgagg accagctcgc gtcgtccgac cgggcggcgg 10201 ccgcggcggt gcgcgcggcg cacggcat //