LOCUS       NZ_RDBM01000011        10228 bp    DNA     linear   CON 01-JAN-2025
DEFINITION  Streptomyces sp. gb1(2016) Scaffold_11, whole genome shotgun
            sequence.
ACCESSION   NZ_RDBM01000011
VERSION     NZ_RDBM01000011.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. gb1(2016)
  ORGANISM  Streptomyces sp. gb1(2016)
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 259573)
  AUTHORS   Hariharan,J., Choudoir,M.J., Diebold,P., Panke-Buisse,K.,
            Campbell,A.N. and Buckley,D.H.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-OCT-2018) Soil and Crop Sciences, Cornell University,
            306 Tower Road, Ithaca, NY 14850, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2018
            Assembly Method                   :: A5+MeDuSa v. JUNE-2018
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 66x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_008042065.1-RS_2025_01_01
            Annotation Date                   :: 01/01/2025 02:23:01
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,414
            CDSs (total)                      :: 7,333
            Genes (coding)                    :: 6,887
            CDSs (with protein)               :: 6,887
            Genes (RNA)                       :: 81
            rRNAs                             :: 6, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 447
            CDSs (without protein)            :: 446
            Pseudo Genes (ambiguous residues) :: 0 of 447
            Pseudo Genes (frameshifted)       :: 94 of 447
            Pseudo Genes (incomplete)         :: 395 of 447
            Pseudo Genes (internal stop)      :: 7 of 447
            Pseudo Genes (multiple problems)  :: 48 of 447
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:17:57
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 236398
            Orig. end                         :: 246626
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            RDBM01000011.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10228
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RiPP-like"
                     /region_number="3"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10228
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10228
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[5000:5228](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5228)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    466..475
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     misc_feature    complement(591..603)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 20.33"
                     /tool="antismash"
     misc_feature    725..740
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 19.99"
                     /tool="antismash"
     misc_feature    complement(1523..1536)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.64"
                     /tool="antismash"
     gene            complement(1841..4114)
                     /locus_tag="EAO74_RS04130"
                     /old_locus_tag="EAO74_04130"
     CDS             complement(1841..4114)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014157698.1"
                     /locus_tag="EAO74_RS04130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EAO74_04130"
                     /product="NHLP family bacteriocin export ABC transporter
                     peptidase/permease/ATPase subunit"
                     /protein_id="WP_147982689.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 2.8e-38, bitscore:
                     124.7, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAPHPSPAAQQLPPPGRGRHRPEGAPGNRRRSRPAPKPKRTRSV
                     HTPTVLQMEALECGAASLAMVLGHYGRHVPLEELRIACGVSRDGSRASNVLKAARSYGL
                     QAKGMQMEPAALAEVQAPAILFWEFNHYVVYDGVGRRLGRRGVHINDPDKGRRFVPAED
                     FDTSFTGVVLVLEPGEDFERGGRKPGVMSALPARLRGTTGTMLVALLASLLLVAVGATL
                     PALSRTYIDMFMIGEQTSLLGVLFAAMGTMVALTVVLTWLQQANLLRGRIISSTLGSAR
                     FFRHLLRLPVTFFSQRSPADLVQRLQSNDAVAETLARDLTAAGVDGIVVLLYAFLLWTY
                     DPQLTVIGVGIALLNVVAMRIVVRLRATGTQKLRADSARLTNTSYTGLQLIETMKATGG
                     ENGYFRRWAGQHATTLDEQQRLGVPSAWLGIVAPALATLNSALILWIGGLRAVEGHISI
                     GLLVAFQALVTRFTAPLTRLNGVAGRVQDFAADVARLKDVESFPVDPLYSRREPAASTR
                     RLKGHVTLEDITFGYSPLDKPLLTGFSLSVGPGQQVALVGGSGSGKSTVSRLISGLYSP
                     WEGTIRIDGRRLEDIPRGALAASVSFVDQDVFLFEGTVRDNVALWDPSVPDEAVTEALR
                     DAALYDVVARRPRGIHSRVEQDGRNFSGGQRQRLEIARALVRRPSILVLDEVTSALDAE
                     TERIIIDNLRRRGCACVVIAHRLSTVRDSDEIVVLDHGTVVERGRHENLVAAGGAYADL
                     VREH"
     gene            complement(4111..4917)
                     /locus_tag="EAO74_RS04135"
                     /old_locus_tag="EAO74_04135"
     CDS             complement(4111..4917)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007386622.1"
                     /locus_tag="EAO74_RS04135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EAO74_04135"
                     /product="HlyD family efflux transporter periplasmic
                     adaptor subunit"
                     /protein_id="WP_124278435.1"
                     /transl_table=11
                     /translation="MQFRQQALSKLQSPEQLDLPVRFARPQGLLVLVVTVAVMAAACVW
                     AVTGSVASTLDAPGILTHSRGSYILQSPVAGQITEVLAEEGQTLPRNSPLLKVRTEQGE
                     RVVRTIDAGRLTSVTATIGAVVTTGADVASVERIDGPDDPLVVLLYVSGSSAASVPVGA
                     SVDLTVQSVPAQQYGVLRGKVAAVGRAAQTQQQITRFLGDAQLGEQFSKHGRPLAVLVK
                     IERSSATESGYRWSSADGPPYAIGSMTLATGSVRLADQRPIDWLLP"
     gene            complement(5001..5228)
                     /locus_tag="EAO74_RS04140"
                     /old_locus_tag="EAO74_04140"
     CDS             complement(5001..5228)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: strepbact"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014157700.1"
                     /locus_tag="EAO74_RS04140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EAO74_04140"
                     /product="type A2 lantipeptide"
                     /protein_id="WP_099171946.1"
                     /sec_met_domain="strepbact (E-value: 6.9e-34, bitscore:
                     110.2, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNYTPQVETAEISDSDLDNVSGGLVGGLVGNATSTVEGIVPVSGV
                     VGSVTGLVESATGVNTGAVTGLASGLTAGL"
     misc_feature    complement(5320..5335)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.69"
                     /tool="antismash"
     misc_feature    complement(5497..5512)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 19.54"
                     /tool="antismash"
     misc_feature    complement(5923..5937)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: strong, score: 28.15"
                     /tool="antismash"
     misc_feature    5924..5938
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: strong, score: 30.11"
                     /tool="antismash"
     gene            5996..8710
                     /locus_tag="EAO74_RS04145"
                     /old_locus_tag="EAO74_04145"
     CDS             5996..8710
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_function="GO:0030246 - carbohydrate binding [Evidence
                     IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014157701.1"
                     /locus_tag="EAO74_RS04145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EAO74_04145"
                     /product="cellulose binding domain-containing protein"
                     /protein_id="WP_410089240.1"
                     /transl_table=11
                     /translation="MRLSARPIAALVAALALTAGLSITGTPAVARPDDRAAAAEASDVS
                     IAADTYTWKNARIDGGGFVPGIVFNRSEKDLAYARTDIGGAYRWDQAGKRWTPLLDWVD
                     WDRWGWSGVVSLASDTAEPDNVYAAVGTYTNSWDPTNGAVLRSSDRGASWKAATLPFKL
                     GGNMPGRGMGERLAVDPNKNSVLYLGAPSGNGLWRSADSGVTWSEVTAFPNPGNYAQDP
                     SDTSGYGNDNQGIVWVTFDERSGSADSATQDIYVGVADKENTVYRSTDGGSTWSRIAGQ
                     PTGYLAHKGVLDSSTGHLYLTLSDTGGPYDGAKGRIWRYDTESGAWTDVSPVAEADTYY
                     GFGGISVDRQKPGTLMATAYSSWWPDTQIFRSTDSGATWTQAWDYSSYPNRSNRYTLDV
                     SSVPWLSWGANPTPPETAPKLGWMTESLEIDPFDSDRMMYGTGATVYGTENLTSWDSGG
                     TFTITPMVKGLEETAVNDLASPPSGAPLLSALGDIGGFRHTDLDAVPAMMFTSPNLDST
                     TSLDFAEASPGTVVRAGNADAAPHIGFSTDNGANWFQGSEPSGVTGGGTVAAAADGSGF
                     VWSPEGAGVHHTTGYGTSWNASTGIPAGATVESDRKNPKKFYGFSAGTFYVSTDGGATF
                     TAKATGLPAEGNVRFKALPGTEGDIWLAGGAPTGAYGLWRSTDSGASFTRLSGVEQADS
                     VGFGKAASGAPYQTVYVSAKIGGVRGIFRSTDAGAGWTRINDDAHQWAWTGAAITGDPR
                     VYGRVYVSTNGRGIQVGESSDTDGPGTDPGPGTDPGTDPGEPPADADCSVAYTVTNRWS
                     GGFQAEVKLTNTGTAAYDGWKLGWTFPGDQRIGQIWNASHQQTGAKVTVTDAGWNGKVA
                     PGSSAAFGFTGTTTGDGTAPGAFTLGGEACAVG"
     misc_feature    6056..6058
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
ORIGIN
        1 gctgcgcgcg aactccgccg cccatgcccc gtacgcgaag ctctccgccg cggcgacccg
       61 cagcttgggc agtccgcgca gtgtctggaa ggcctggttg ttgagcttgt tgcccagcac
      121 caccagccgg cgctgccagc ggagctccca catgcccatg gtgaggaaca ccccggcgat
      181 gaccaccagc atggcgaccg cggtgagggc cagcggaacg ctgaaccaga gcagcaggcc
      241 cagattcatc gcccccagcg tgcccgcctg caccaccacg ggaccggtgc cggacagcac
      301 ccggcggatc gcgctcaccc ccatcgccgc gctcgccagc tcacccgtgg agcgcccggt
      361 gaagaacttc gtcggcagcc gcagcagccg gtcccacacc gcgggctgga gcgtgctctc
      421 gatccgcccc tccatccgca ggatggtgag gttctgcagc agcatgaagg cggccgagac
      481 gaccccggag atgatgaccg ccagcgacgc ctgcacgatg agcgcgttct gggcgttggg
      541 cacgtacacg ccgagcacct tgccggtcgc gatcggcacc agcgagccca gtgccaccgt
      601 caccaggccc gcgggcacca gcctccgcag atcgccccgg gtgccgaaga ggccgaagcg
      661 cagcaactgc cacttgccca gcgggcgttc gggcagcggg cggtagaaca tcacggcgcg
      721 ctcgtcgaac tcctgcgcgg atgcgctgtc gacacggctg cgccggccgg tcagcgggtt
      781 gaccgcctcg tagcggccac ggcgccagag cagggccacc ggtgccccgg acgcggtgcg
      841 gtgacccacc agcggaccgg agttctcccg ccaccagcgc cccgcgagcc gcaccgggcg
      901 ggtgcggatg cgcgaggcga ccgcgacacg ctcgaccggg tcgatccggt cgctcaccgc
      961 cccgcccgtg gccggttcgg cgaggacgat cccggagtcc ctggccacca ggaggcaggc
     1021 cgcgtacacc gcgtcgtccg agccccccga cgccggcgag gcgcccctgc cggaccggcc
     1081 gatcgaggtc agcagcgcct ggtcggcctc cttgcggacg gcctcgcccg ccttcatgcc
     1141 cgccgcggtg cggtcctcgt gggcgcgctc cagctgctcg atccagcggt ccagcgccga
     1201 cagcaggcgg tactgctgat tgaccatccc ctgccacatc gccgggtcga cgagcaggtc
     1261 acccgccgcc tcggcgctga acgcggcgcc gtactgcaca ctgcccggtg agaccggcag
     1321 ccacaggatg tcgtcgtcgc ccaccgtccc gtcgaaggtg gtccgcccgt ccagcggggc
     1381 ctcgaacagc acccgctggc tccggcccac gcccagcgag aaggcgtgct ccagcaagct
     1441 cagcgcagcg tccccggtgt cgtagtgact gcggtactgc ccctcgtacg ccccctggcc
     1501 ggcgtactcc ggccggtaca gctcacgcag cgggatccgg cgcagcacgc actcctggag
     1561 ggggcggccc accagggtgt gctgcgggcc ctcgaccggg cccaggacga gcgtccccgg
     1621 ttcgagccgg cccaggaagt gccagtgccc ctgctccacc gcgtccaccg cgaacaggtc
     1681 gagggcgccg cccacgacga gccacagcac ctgggggccc tccagcgaca ggctccgcag
     1741 accggtgcag tccacgggct caccgagggc tcccagcgct ccgatgaccg ggtcctgccc
     1801 gggcgcctcc gtgcccgcga ggggatgtgt ggatgccacg tcagtgctcc ctgaccagat
     1861 cggcgtacgc gcccccggcg gccaccaggt tctcgtgccg gccgcgttcc acgaccgtgc
     1921 cgtggtccag gaccacgatc tcgtcgctgt cgcgcaccgt gctcagccgg tgggcgatca
     1981 cgacacaggc gcagccgcgc cggcgcaggt tgtcgatgat gatccgttcc gtctcggcgt
     2041 ccagcgcact ggtgacctcg tccaggacca ggatgctggg gcggcgtacg agcgcgcggg
     2101 cgatctccag gcgctgacgc tgcccgccgg agaagttccg gccgtcctgc tccacccggc
     2161 tgtggatccc gcggggccgg cgggcgacga cgtcgtacag ggcggcgtcc cgcagggcct
     2221 cggtcaccgc ctcgtccggg accgagggat cccagagcgc cacgttgtcc cgcaccgtcc
     2281 cctcgaagag gaagacgtcc tggtcgacga aggacaccga cgcggccagc gcgccccggg
     2341 gtatgtcctc caggcgccgg ccgtcgatac ggatcgtgcc ctcccacggg ctgtagagcc
     2401 ccgagatgag ccgggagacc gtcgacttgc cgctgcccga accgccgacg agtgccacct
     2461 gctgccccgg ccccaccgac agcgagaaac cggtgagcag cggcttgtcg agcgggctgt
     2521 agccgaaggt gatgtcctcc agcgtcacat ggcccttgag ccgccgggtg ctcgcggccg
     2581 gttcccggcg cgagtacagc ggatcgaccg ggaagctctc cacgtccttg agacgggcca
     2641 cgtcggccgc gaagtcctgc acccggcccg ccaccccgtt gagccgggtc agcggcgcgg
     2701 tgaaccgggt caccaacgcc tggaaggcga cgagcagacc gatcgagatg tgcccctcga
     2761 cggcccgcag cccgccgatc cacaggatca gtgcgctgtt gagcgtcgcc agggcggggg
     2821 cgacgatgcc cagccaggcg ctcggcaccc cgagccgctg ctgctcgtcc agcgtcgtcg
     2881 cgtgctgtcc ggcccaccgc cggaagtagc cgttctcgcc cccggtcgcc ttcatcgtct
     2941 cgatcagctg gagaccggtg tacgaggtgt tcgtcagccg tgcgctgtcg gcccgcagct
     3001 tctgggtgcc ggtggcccgc agccgtacga cgatgcgcat cgcgacgacg ttgagcagcg
     3061 cgatgcccac cccgatgacg gtcagctgcg gatcgtaggt ccacagcagg aaggcgtaga
     3121 ggaggacgac gatgccgtcc acgccggccg cggtgagatc ccgggcgagg gtctcggcga
     3181 cggcgtcgtt ggactggagg cgctggacga ggtcggcggg gctgcgctgg gagaagaagg
     3241 tgacgggcag ccggagcaga tgccggaaga agcgcgcgct gccgagcgtg gacgagatga
     3301 tccgcccgcg cagcagattc gcctgctgaa gccaggtcag gacgaccgtg agcgcgacca
     3361 tcgtgcccat cgcggcgaac agcacgccca gcagcgaggt ctgctcgccg atcatgaaca
     3421 tgtcgatgta ggtacggctc agggccggga gcgtcgcccc gacggccacc agcagcaggc
     3481 tggcgagcag cgcgaccagc atcgtgcctg tggtgccgcg cagccgggcc ggcagcgcgg
     3541 acatgacgcc gggcttacgg ccgccgcgct cgaagtcctc gccgggttcg aggacgagga
     3601 cgaccccggt gaagctggtg tcgaaatcct cggcgggcac gaaccggcgg cccttgtcgg
     3661 ggtcgttgat gtgcaccccc cgccgtccga ggcgacgccc cacaccgtcg tacacgacgt
     3721 agtggttgaa ctcccagaac aggatcgcgg gcgcctggac ctccgcgagg gccgcgggct
     3781 ccatctgcat gcccttggcc tggagaccgt aactgcgggc tgctttcagt acgttgctgg
     3841 cccgtgagcc gtcgcgcgag acgccgcagg cgatccgcag ctcctccagc ggcacatggc
     3901 ggccgtagtg gccgagcacc atcgccagcg aggcggcacc gcactccagg gcctccatct
     3961 ggagcaccgt gggggtgtgc acgctcctcg tccgcttggg cttcggcgcc ggacgcgacc
     4021 gccgcctgtt gcccggggcg ccctccgggc ggtgcctgcc gcggccgggc ggcggcagct
     4081 gctgggcggc gggggacgga tgcggtgcgg tcacgggagc agccaatcga tcgggcgctg
     4141 gtcggcgaga cggacggagc cggtggccag ggtcatggag ccgatcgcgt acggggggcc
     4201 gtcggcggag gaccagcggt agccggactc cgtggcggac gagcgttcga tcttcaccag
     4261 gaccgccagt ggccgcccgt gcttcgagaa ctgctcgccg agctgggcgt cgccgaggaa
     4321 gcgggtgatc tgctgctgtg tctgcgccgc ccggccgacg gcggccacct tgccgcgcag
     4381 caccccgtac tgctgggcgg gcacggactg gacggtgagg tcgacggagg cgcccaccgg
     4441 gaccgacgcg gcactgctgc cggacacgta gagcaggacg accagcgggt cgtcggggcc
     4501 gtcgatccgc tcgacgctcg ccacgtccgc gccggtggtg accacggcgc cgatcgtggc
     4561 ggtgaccgag gtgagccggc ccgcgtcgat ggtgcggacg acgcgttcac cttgctccgt
     4621 acggaccttg agcagagggg agttgcgggg gagggtctga ccctcctcgg cgagcacctc
     4681 ggtgatctgc ccggccaccg ggctctgcag gatgtaactg ccgcgggagt gcgtgaggat
     4741 gccgggggcg tccagggtgc tcgcgacgga gcccgtcacg gcccagacgc aggcggcggc
     4801 catcacggcg acggtgacga cgaggacgag caggccctgc ggtcgggcga agcgcaccgg
     4861 cagatcgagc tgttcgggcg actgcagctt ggaaagggcc tgctggcgga actgcacgga
     4921 actcttgcct cacctgtcag cggtcggcac cgagccccgg aaccgacggg ttccggggct
     4981 cggtggggtc ctgccgtgtc tcagagaccg gcggtcaggc cggaggccag gccggtgacc
     5041 gcgcccgtgt tcacgccggt ggcggactcg acgagaccgg tgaccgagcc gacgacgccg
     5101 gagaccggga cgatgccctc gacggtgctc gtggcgttgc cgacgaggcc gccgacgagg
     5161 ccgcccgaga cgttgtcgag gtcgctgtcg gagatctcgg cggtctcgac ctggggggtg
     5221 tagttcatga tgagcgctgc ccttcgtatg gaaattgcct atatacggaa acccgtggtg
     5281 cgacctccgt atgggccagg atcaaagcac gcctgcgcct cgtacagcca atcgaactgc
     5341 ggcggatctg tggttatcgg gccgctggaa tcgacgtacg tgcagaagtg ttcatttcgt
     5401 ggcggcagat ccttcacgag cttcaccgga tgaattccgt gtcggcgcaa cttcacgccc
     5461 cccaagtagg gcactcccgc cccaatcgcc ccacggaccg gtctggacct ggccttctgt
     5521 cccgagtcgc gtgatcggtg tgcgcacgcc gtgtgcaggt tttttcgata cgggggcgca
     5581 tccgcaattc cgggcgccgg agccgcacgg ctccgcagga ggttcggcgg ctatcggtat
     5641 tcacgctacc gtgaaagatg aacacggctc tcttttctcc gtgttccgtc tgcgaatgga
     5701 cggcgccttt atgaagcact ttccgggtat gcgtgttcac cgtgtcacct ggtctccggg
     5761 tatatggaga agatgtgccg ccttctgtgg gcgcggtgga cggtgtgggc gtccgtgcgg
     5821 ccgggccggc ggcggcgtgc ggtgctcggc ccgattcatc cgatgaaacg actgcaccac
     5881 ccttctgtgg ggcgacgcgc ggcgctacca tcgggatgcc ttttgggagc gctcccatct
     5941 cttgtcggcc ccgtaccgcc cctcaggggc ggaccagctc ggagaggacg tttccgtgcg
     6001 cctgagcgcc agaccgatcg ccgccctcgt ggcggcactt gccctcaccg ccgggttatc
     6061 gatcaccgga accccggccg tggcacgccc cgacgacagg gccgccgcgg ccgaagcatc
     6121 ggatgtgtcc atcgcggcgg acacgtacac atggaagaac gcccggatcg acggcggcgg
     6181 ctttgtgccg ggcatcgtct tcaaccggtc ggagaaggac ctcgcctacg cgcgcaccga
     6241 catcggcggc gcctaccgct gggaccaggc gggcaagcgg tggacgccgc tgctggactg
     6301 ggtggactgg gaccggtggg gctggtccgg ggtggtgagc ctcgcctccg acaccgccga
     6361 gccggacaac gtgtacgccg ccgtcggcac gtacaccaac agctgggacc cgacgaacgg
     6421 ggcggtcctg cgttcctcgg accgcggtgc ctcctggaag gcggccacgc tgcccttcaa
     6481 gctcggcggc aacatgccgg gacgagggat gggggagcgg ctcgcggtcg acccgaacaa
     6541 gaactccgtg ctgtacctcg gcgctcccag cggcaacggg ctgtggcgtt cggccgactc
     6601 gggggtcacc tggtcggagg tgaccgcctt ccccaacccc gggaactacg cgcaggatcc
     6661 gtccgacacc agcggatacg gcaacgacaa ccagggcatc gtgtgggtca ccttcgacga
     6721 acgctccggc agcgcggaca gcgccacgca ggacatctac gtcggggtcg ccgacaagga
     6781 gaacaccgtc taccgctcca cggacggcgg ttccacctgg tccaggatcg ccggccagcc
     6841 gaccggctac ctcgcgcaca agggcgtact cgactcctcg acgggccacc tctatctgac
     6901 gctgagtgac acgggcggcc cctacgacgg tgccaagggc cggatctggc gctacgacac
     6961 ggagtcgggc gcctggacgg acgtcagccc cgtcgcggag gccgacacct actacggctt
     7021 cggcggcatc tccgtcgacc ggcagaagcc cggcaccctg atggcgaccg cgtacagctc
     7081 gtggtggccc gacacccaga tcttccgctc caccgacagc ggcgccacat ggacccaggc
     7141 ttgggactac agcagctatc cgaaccgctc caaccggtac acgctggacg tctcctccgt
     7201 gccctggctc agctggggcg cgaaccccac cccgccggag acagcgccca agctgggctg
     7261 gatgacggag tccctggaga tcgacccctt cgactcggac cggatgatgt acggcacggg
     7321 agccacggtc tacggcaccg agaacctcac gtcctgggac tccggcggca cgttcacgat
     7381 cacgcccatg gtcaagggcc tggaggagac cgccgtcaac gacctggcga gcccgccctc
     7441 gggcgcgccc ctgctgagcg cgctcggtga catcgggggc ttccggcaca ccgacctcga
     7501 cgcggtgccc gccatgatgt tcacctcgcc gaacctggac tcgaccacca gcctggactt
     7561 cgccgaggcg tcccccggca cggtcgtacg ggccggcaac gcggacgccg ctccgcacat
     7621 cggcttctcc accgacaacg gcgccaactg gttccaggga tcggagcctt ccggtgtcac
     7681 gggcgggggc acggtcgccg ccgcggcgga cggcagcgga ttcgtctgga gcccggaggg
     7741 cgcgggcgtc caccacacca ccggctacgg cacctcctgg aacgcctcca ccgggatccc
     7801 cgccggggcg acggtcgagt cggaccggaa gaacccgaag aagttctacg ggttcagcgc
     7861 cggcaccttc tacgtgtcga ccgacggcgg cgccacgttc accgcgaagg cgaccggact
     7921 cccggccgag ggcaacgtcc gcttcaaggc gctgcccggc acggagggcg acatctggct
     7981 cgcgggcggc gctccgacgg gtgcgtacgg gctctggcgc tccaccgact ccggcgcgag
     8041 cttcaccagg ctctccgggg tggagcaggc cgacagcgtc ggcttcggca aggcggcctc
     8101 cggggccccg taccagaccg tctacgtcag cgcgaagatc ggcggggtgc gcggcatctt
     8161 ccggtccacg gacgccggcg ccggctggac acggatcaac gacgacgcgc accagtgggc
     8221 ctggacgggc gcggcgatca ccggggaccc gcgggtctac ggccgcgtgt acgtctccac
     8281 gaacggccgg gggatccagg tcggcgagtc ctcggacacc gacggcccgg gcacggaccc
     8341 gggccccggc accgaccccg gcaccgatcc gggggagccg ccggcggacg cggactgctc
     8401 ggtggcgtac acggtcacca accggtggtc cggcggcttc caggccgagg tgaagctcac
     8461 caacaccggc accgccgcct acgacggctg gaagctgggc tggaccttcc ccggtgacca
     8521 gaggatcggt cagatctgga acgcctccca ccagcagacc ggtgcgaagg tgaccgtcac
     8581 cgacgccggc tggaacggga aggtggcccc cggctcctcg gccgccttcg gcttcaccgg
     8641 tacgacgacg ggcgacggca ccgcgcccgg cgcgttcacg ctgggcggtg aggcctgcgc
     8701 cgtcggctga ccccctgccg ggcaggtgcg ggagtgccgg ccccgcgggc cgccaaatgg
     8761 acataccgcc cggggcgtgc tgcattggag tgaacgcacc acgccctggg aggtaccccg
     8821 tggccgacgt cgacgtgctg atcgcggggg cgggccccgt cggcctgaca gccgcctccg
     8881 agctgtgccg ccgcggcgtg gcgtgccggg tcgtcgaccg gctcccggag aggctcccct
     8941 tcgcacgtgc cgtgggcgtc cagccgcgga cgctggagat ctgggatcgg atggggatga
     9001 tccgggaggc gctggagacg gccgtcccgt tgaagggcca gttgctgtac gtcaacggtg
     9061 aggagggccc gcggatcgac ctcgcactgc cgcccgaggt gccgtaccgc ttcgcggcac
     9121 tcccgcagta cgagaccgag cgcctcctgg aggacctcct ccgccgctgc gggggcgagg
     9181 tcgaacgcgg caccgcactc gtctccttcg cgcaggaccc ccacgtggtg agagccgtcc
     9241 tctccctgcc cacgggcggc accgaggaac tgacggcccg ctacctcatc ggctgcgacg
     9301 gcgcccacag cgtggtccgc aaggggctgg gcctgtcctt cgaaggcgcg gcgctccccg
     9361 aggagtacat gctgggcgac gtcgaggtcg actgggatct gccggccgga tacgcggtcc
     9421 ggtcctcgaa cgtcgtcgac gggctcaccg acgacctgtt ggtgtgcatc ccgctgcccg
     9481 gcgaccaccg ctaccggatg tccatggcga cccctcccga actgtcccgt gcggggcaga
     9541 aggacgcgga cggtgtcacg cacggcctga gcggggaaca ggggcccgtg cccggcctcg
     9601 aacacatcca ggccgtgctc gaccggctct ccccgcgccc cacgaccgcg acctccctgc
     9661 gctggtcctc cgtgttccgc atcagccacc gcatcgtcga ccggtacggg cacgggaggg
     9721 tcttcgtggc cggggacgcc gcgcacatcc acccgcccac cggcgcccag gggatgaaca
     9781 ccggcgtcca ggacgcgtac aacctggcct ggaaggtcgc cgcggccgtg cgcggccacg
     9841 cgggtgccgg gctgctggag agctacgacg ccgaacgccg gccgatcggt gaggaagtgg
     9901 tggaccgcac gctgcgccac gcgaggagcg gcatccaggc cgaccccgac gacccggcga
     9961 ccacgatgct ccgtgaagcc cagctcctcc tcggctaccg gggcagcgcg atcgtgggac
    10021 cggtcggctc cgcgcacgac ggcccggaac cgggcgaccg ggcgcccgac tgcggaggcc
    10081 tcctgtacgc cctgagggcc ttccccgtcc ggctgttcag cctgctgcgg gagcgcgagc
    10141 acaccctgct cctctacgcc gaccacgagg accagctcgc gtcgtccgac cgggcggcgg
    10201 ccgcggcggt gcgcgcggcg cacggcat
//
