LOCUS       NZ_CP042828            22826 bp    DNA     circular CON 27-APR-2024
DEFINITION  Ruania zhangjianzhongii strain HY168 chromosome, complete genome.
ACCESSION   NZ_CP042828
VERSION     NZ_CP042828.1
KEYWORDS    RefSeq.
SOURCE      Ruania zhangjianzhongii
  ORGANISM  Ruania zhangjianzhongii
            Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Ruaniaceae;
            Ruania.
REFERENCE   1  (bases 1 to 5067305)
  AUTHORS   Huang,Y.
  TITLE     Ruania sp. HY168
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 5067305)
  AUTHORS   Huang,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (12-AUG-2019) National Institute for Communicable Disease
            Control and Prevention, Chinese Center for Disease Control and
            Prevention, Changping, Beijing 102206, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. HGAP 3.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 178.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_008000995.1-RS_2024_04_27
            Annotation Date                   :: 04/27/2024 03:28:42
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,709
            CDSs (total)                      :: 4,654
            Genes (coding)                    :: 4,621
            CDSs (with protein)               :: 4,621
            Genes (RNA)                       :: 55
            rRNAs                             :: 2, 2, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 2, 2 (5S, 16S, 23S)
            tRNAs                             :: 46
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 33
            CDSs (without protein)            :: 33
            Pseudo Genes (ambiguous residues) :: 0 of 33
            Pseudo Genes (frameshifted)       :: 13 of 33
            Pseudo Genes (incomplete)         :: 20 of 33
            Pseudo Genes (internal stop)      :: 1 of 33
            Pseudo Genes (multiple problems)  :: 1 of 33
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 07:19:52
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4182049
            Orig. end                         :: 4204875
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP042828.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22826
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="7"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..22826
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22826
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12826]"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12826
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     misc_feature    645..660
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 19.62"
                     /tool="antismash"
     gene            complement(909..2585)
                     /locus_tag="FU260_RS24260"
     CDS             complement(909..2585)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF027967.4"
                     /locus_tag="FU260_RS24260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="fibronectin type III domain-containing protein"
                     /protein_id="WP_244951248.1"
                     /transl_table=11
                     /translation="MEQDASNWLRFDVFSSGGVVRAFAGATTNGSSKMRFNQVLPVQPS
                     DSVVVGVSRAGNVWTMTVAVDGGSPQVIGTFSQALTVGAVGPFAANAGSNPAEYTALVD
                     FVFDRANPIVPEDGGAGPAPDPDPDPDPDPDPEPDPDPDPEPEPDVTAPVVSAVEASPT
                     SSSAVISWSTDEETTGAVAFGETTSYGSTRTSSGSGTSHSATLTGLAAETTYHYRVTAT
                     DTSGNTTVTGDGVFTTPASSVAIDVWYGPDQSFGSPARPQERVNIVGSVSNSASVTSLT
                     YSVNGGSARGLSIGPDNRRLAAPGDFNADIPYTDLNTGQNVVTISALGSDGSSATQTVN
                     VTVYAAEALSLPYATDWSASEPLQLQAQSVDGLWQTGNGSVSTVQLGYDRILAVGDSSW
                     TDYEVTVPMTLHAFGPGAGQYLSGAAMIGIGLRWQGHTRVQGEPLPYGWYPAGAYSWYR
                     FHDNGPRWELFGNHNTPVDRGRRNAIDFGPGDTYIMRVRAESLPSGGATYSMKMWEQGT
                     AEPTSWMGTITDDDSVPSGSVVLIAHHVDATFGNVTVTPVP"
     misc_feature    complement(2834..2848)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.96"
                     /tool="antismash"
     misc_feature    complement(3274..3289)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.42"
                     /tool="antismash"
     misc_feature    complement(3845..3859)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.96"
                     /tool="antismash"
     gene            complement(3980..4906)
                     /locus_tag="FU260_RS19290"
     CDS             complement(3980..4906)
                     /EC_number="2.4.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012745.4"
                     /locus_tag="FU260_RS19290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycosyltransferase"
                     /protein_id="WP_147918520.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 1.1e-28,
                     bitscore: 98.3, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTPRLTIGLPVYNGEAYLAETLESLLAQDFEDFELVVSDNASTD
                     ATVSIVESFAERDARVRLVRNDRNRGAAYNYNRLVADSDAELFKWSGYDDLLEPGYVRS
                     CVAALDANPAAVIAFAQATIIDGAGRRIRPYAEKLDVVASTPWRRVASFAWRFNLCNAC
                     FGVMRRETMASTGLIRPYMSSDVTFLAEMAALGSFALVDERLFLRRVHESSSRQGHTTA
                     AEVARWFDPASRSAPSFVRLKLLGRTTGALATGAAPIPDRLGAAAGFAAAYSARRARIA
                     AGGLRARFRGTAAAPAELIHEVDGKVS"
     gene            complement(4903..6111)
                     /locus_tag="FU260_RS19295"
     CDS             complement(4903..6111)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024880.4"
                     /locus_tag="FU260_RS19295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_147918521.1"
                     /transl_table=11
                     /translation="MRGTEVVIGSIDDVGGCPACGAAAPEPFHLGEPVPVNSCLLLRDR
                     AAAVDFPQGELALALCPACGLIWNGQFDPALTTYSQDYEETQGFSPTFQAFIRELATDW
                     TERYSLSGGTVVEIGCGKGEFLVEMTRAGVGTAIGIDPGVQPSRVADDVPITWIQGLFP
                     QDLPELRADAIVCRHTLEHIAPVREFLTSIRAAITEPDRTVLLFEVPDVLRVLDEVAFW
                     DVYYEHSSYFSAGSVGRLFRAAGFEVLRIERAYSDQTLLVEARPAIGGLAGVLPIEESP
                     AELAEAAGRFARGHQAMVEHWRDRIQAVEAGGGRTVIWGGGSKGVAFLAALGAHSDLVA
                     GVVDINPFKQNQYMAGTGHRVLAPKELTTVEPALVIVMNGAYRTEIGNELADLGLTPIV
                     EAL"
     misc_feature    complement(6444..6459)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.57"
                     /tool="antismash"
     misc_feature    complement(6445..6459)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.6"
                     /tool="antismash"
     misc_feature    complement(6524..6539)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 19.85"
                     /tool="antismash"
     gene            6553..7134
                     /locus_tag="FU260_RS19300"
     CDS             6553..7134
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FU260_RS19300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_147918522.1"
                     /transl_table=11
                     /translation="MGSAHLLLVITLLALLTGCFTVRDNRSTAPEGPEPTARTVVDGVE
                     TWDLTFEPSEEGFGIEGDSTAEIYETDEPRTIVLKLPGGESLRLDAQVIAFSRFSGAAG
                     DRYTVGVRGATVEPEDLGEQLRVLLEQLETSPDEVDEFIAEVNDAPADQTERVRFSSPR
                     VTFGDLRLGVGANVAPIAEGGRFTLGGAWD"
     gene            7264..8652
                     /locus_tag="FU260_RS19305"
     CDS             7264..8652
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FU260_RS19305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_147918523.1"
                     /transl_table=11
                     /translation="MTTRTGTHHPRTRRWTIGICAALALALAVGLGLWLRSDGFRIANE
                     IGDLTGVESAGLVPTEGAASEEILRVEIAPSTGRAEIETILETTEEVIDDEVVPAARVS
                     LGTAEVKVGARYRAGIRDAAQVLVALSTLADGRAILDERNIVFVEATEPPLANILDWLT
                     LIEEESLRVEDVTVEGEDGWNAISIYRPQTNHREALEALREWDPDVTSITLEETSLTIR
                     TTIPFLDLGPLAQDAQSAARILNPESPRVRLETSDQRRLSVGDEDPGTALEMAGKIEDD
                     GWAVHSLNSGLTSIDVAHADRTVDPSQLPDLAEALRSAGLPQEATTRVDEGALFWGTRS
                     DLEDLAPSIAQAHADGYLVRWTRDDRGPGPDARVWVELPTGHSLSEGSDLAGAIDVARS
                     IPWPGTGLITLQTTPESGSYKDEREVTLNSTATGTAEDVQVDPDYLPGEGQVQDAWDAT
                     ATEN"
     gene            complement(8649..9851)
                     /locus_tag="FU260_RS19310"
     CDS             complement(8649..9851)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045: glycosyl transferase group 1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009072118.1"
                     /locus_tag="FU260_RS19310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycosyltransferase family 4 protein"
                     /protein_id="WP_235912394.1"
                     /sec_met_domain="Glycos_transf_1 (E-value: 5.9e-15,
                     bitscore: 53.4, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MALVRGHALIIIQNLPLRLDRRVRNECRALLDAGYDVSVICPKED
                     SAEPDRHEIDGAVVFSYPAPEGARGLLSYAREFVVCWLHAARLSVRVNRERRFDVLQAC
                     NPPDTYWLLGAWWKLRGRRFVFDQHDLCPEVYEARFGKRGFLHRALLWLERQTYRVADR
                     VVSPNPSYRDLAVQRGRLPQARTAVVMSTPDPERMRRAAEHPELRGGLSHLVCYVGIMG
                     PQDGVDALLAAVDVYVHQLDRRDTRFVLLGFGDSLEGLMADCTRRGLDEWVTFTGRVDH
                     EELGRWLSTADLGVTPDPQNEFNHRSTMNKTLEYMAHEVAVVATDLQETRRCAADAAVY
                     VSGADPAETAAAIAELLDDPERRAEMGRAGRARIETELAWSLQARAYVGVFDQLVERRR
                     S"
     misc_feature    complement(9807..9821)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 18.36"
                     /tool="antismash"
     gene            10001..10285
                     /locus_tag="FU260_RS19315"
     CDS             10001..10285
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018170381.1"
                     /locus_tag="FU260_RS19315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PqqD family protein"
                     /protein_id="WP_235912395.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 1.4e-20,
                     bitscore: 71.2, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 3.5e-18, bitscore: 63.8,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRSSWRLAMKLRANEVSVREIDGEMVLLDLRTSKYLSANRVGTIL
                     LQLLAEERSADELADALVAEFDVPHETALADVTMFVDELRTRGLLEPAG"
     aSDomain        10034..10273
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_FU260_RS19315_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="8.60E-23"
                     /identifier="RREFam002.1"
                     /label="FU260_RS19315"
                     /locus_tag="FU260_RS19315"
                     /protein_end="91"
                     /protein_start="11"
                     /score="71.2"
                     /tool="antismash"
                     /translation="RANEVSVREIDGEMVLLDLRTSKYLSANRVGTILLQLLAEERSAD
                     ELADALVAEFDVPHETALADVTMFVDELRTRGLLE"
     gene            10304..10741
                     /locus_tag="FU260_RS19320"
     CDS             10304..10741
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF033537.1"
                     /locus_tag="FU260_RS19320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_147918524.1"
                     /sec_met_domain="PF13471 (E-value: 8.8e-16, bitscore: 56.1,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRRVPVREVPAVIAALALACAVEVGLRTLSLPRTARLVGAPLRST
                     SSPTAPQVRGARLGRRGRRQARAVQRVMRHWPFGDTCLRHALVAGHRLRRFDPELVVGV
                     AKVDGEIRAHAWLEFDTGLYDPLRAAQAYLPLGSPRPVEEE"
     gene            complement(11564..12826)
                     /locus_tag="FU260_RS19325"
     CDS             complement(11564..12826)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012936.4"
                     /locus_tag="FU260_RS19325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="asparagine synthase C-terminal domain-containing
                     protein"
                     /protein_id="WP_168211868.1"
                     /sec_met_domain="Asn_synthase (E-value: 3.1e-20, bitscore:
                     71.2, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLIYQRLTDTEVGVAAPLGSVAVVNDDPAADARTVRAALERAVTD
                     AVSSSGPCYVLFSGGRDSSLILALATHAARQLGADDPVPVTAVYPGDEQADETDWQDLV
                     LEHLGLTERLVLSVTDERSTLGELATTHLRRRGLVWPEAVHTQPLFFAQLGSGTVLTGE
                     GGDAFLEGRRVTPLFLLRRRRRLPSLALLRAAGAALLPAAVVRAQARRTYADPDLLPWL
                     RPAAREILAADEAALRGPLRWDVATWAIHHQRTTRLGLDNAVVSAAEYGLTMRHPIAET
                     AVVAALAAEGGGWGFPGRTHLFRRLGADLLPDAVLARRSKAAFNASRWAEPEREFARSY
                     TGGAFDPDLIDDARLQEVWLSPRPHPVSYFLAQIAWLHQHGLPQLPRVAAEGPRTGQQP
                     AMGRTAAPTGAGPRTPGSAPR"
     gene            complement(12896..13036)
                     /locus_tag="FU260_RS19330"
     CDS             complement(12896..13036)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FU260_RS19330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="lasso RiPP family leader peptide-containing
                     protein"
                     /protein_id="WP_147918526.1"
                     /transl_table=11
                     /translation="MSIYEAPMLTEVGSVREMTLGGANLQDWSDEIRLWKVTIPLPGEF
                     S"
     gene            complement(13222..14286)
                     /locus_tag="FU260_RS19335"
     CDS             complement(13222..14286)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_5"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF026257.4"
                     /locus_tag="FU260_RS19335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="nucleotidyltransferase family protein"
                     /protein_id="WP_147918527.1"
                     /sec_met_domain="NTP_transf_5 (E-value: 3.1e-35, bitscore:
                     120.0, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAIARGERPSITPALRADPAAFAGAARYHRLAPLAHVLLRDGEPD
                     LAQAVQRDRDQARALHLHATTLLGHLGDLLDGVGWVVFKGPVLSELAHPVPGLRSYQDL
                     DLLVRPEDLREVSVRLLGAGWTIADFEDMLRNPQLPGEMHWRSPTGVLMDLHWSMINMA
                     DRRRRLTVPTADLLHRREQVSLGFASAWTLDPVDGLLHVCLHAALTGANKLLYLVDAQR
                     MAARITDWALVGERAADWRAAPHVALVLHRAQRSLGGELPEGLDRLLGSTAAFRALTAA
                     VDRAAPVAAARTEPGVARLVARAVRPGAVRTTLASAQSVARRLSERPAQARTGRSPAGD
                     GALDLYLDRVEATS"
     gene            complement(14490..15902)
                     /gene="rfbD"
                     /locus_tag="FU260_RS19340"
     CDS             complement(14490..15902)
                     /EC_number="1.1.1.133"
                     /GO_function="GO:0008831 - dTDP-4-dehydrorhamnose reductase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009243 - O antigen biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0019305 - dTDP-rhamnose biosynthetic
                     process [Evidence IEA]"
                     /NRPS_PKS="Domain: NAD_binding_4 (225-338). E-value: 4e-07.
                     Score: 21.3. Matches aSDomain:
                     nrpspksdomains_FU260_RS19340_NAD_binding_4.1"
                     /codon_start=1
                     /gene="rfbD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) dTDP_sugar_isom"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017203272.1"
                     /locus_tag="FU260_RS19340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="dTDP-4-dehydrorhamnose reductase"
                     /protein_id="WP_147918528.1"
                     /sec_met_domain="dTDP_sugar_isom (E-value: 6.2e-30,
                     bitscore: 102.1, seeds: 19, tool: rule-based-clusters)"
                     /sec_met_domain="RmlD_sub_bind (E-value: 6.7e-73, bitscore:
                     243.3, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVFGKPLTITGTTIDGLLLVDLPVHGDDRGWFKENWQREKMVAA
                     GLPDFAPVQQNISYNDQIGTTRGIHAEPWDKWVSVATGRLFGAWVDLREGPGFGRVVTA
                     ELDPSRAVYVPRGVGNAFQTLLPGTAYTYLVNDHWTAEASYPLLNLADPTLAIDWPIPL
                     ADAVVSAKDQGHPHLAEVTGVRPRKTLVLGSDGQLGRALRDRLGEAAHLEYAGRTDLDL
                     TDPGLAEARHWRDYEAIINTAAYTDVDGAETPAGRAQAWAVNATAVAALARVATEHRLT
                     LVQVSTDYVFDGAAPVPYAEDAPLCPLGVYGQSKAAGEAAASTAPRHYLVRTSWLIGDG
                     PNFVRTMAALAERGIDPRVVADQVGRLTVTSDLAAAIVHLLHTAAPYGTYHVTGSGPPR
                     TWADIARTVFSLTGHDPARVQEVSTPEYFAGATAPVAPRPANSVLDLAKIIATGYRPAA
                     ADTALAEYLQDA"
     aSDomain        complement(14889..15227)
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_FU260_RS19340_NAD_binding_4.1"
                     /evalue="4.00E-07"
                     /label="FU260_RS19340_NAD_binding_4.1"
                     /locus_tag="FU260_RS19340"
                     /protein_end="338"
                     /protein_start="225"
                     /score="21.3"
                     /tool="antismash"
                     /translation="GLAEARHWRDYEAIINTAAYTDVDGAETPAGRAQAWAVNATAVAA
                     LARVATEHRLTLVQVSTDYVFDGAAPVPYAEDAPLCPLGVYGQSKAAGEAAASTAPRHY
                     LVRTSWLIG"
     gene            complement(15899..16897)
                     /gene="rfbB"
                     /locus_tag="FU260_RS19345"
     CDS             complement(15899..16897)
                     /EC_number="4.2.1.46"
                     /GO_function="GO:0008460 - dTDP-glucose 4,6-dehydratase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009243 - O antigen biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0019305 - dTDP-rhamnose biosynthetic
                     process [Evidence IEA]"
                     /NRPS_PKS="Domain: NAD_binding_4 (5-180). E-value: 2.7e-17.
                     Score: 54.6. Matches aSDomain:
                     nrpspksdomains_FU260_RS19345_NAD_binding_4.1"
                     /codon_start=1
                     /gene="rfbB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_binding_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018768482.1"
                     /locus_tag="FU260_RS19345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="dTDP-glucose 4,6-dehydratase"
                     /protein_id="WP_147918529.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 5.5e-16, bitscore:
                     56.6, seeds: 37, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 2.8e-11,
                     bitscore: 41.2, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="NAD_binding_4 (E-value: 2.1e-15, bitscore:
                     54.6, seeds: 102, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMRLLVTGGAGFIGSNFVRHVLAHTEASVTVLDALTYAGNRDSLA
                     GLPSDRLQFVRGDITDAALVGQLVPAADVVVHFAAESHNDNSLHDPRPFLTTNIVGTYT
                     LLEAVRAHDVRFHHVSTDEVYGDLALDSPDRFTEDTPYHPSSPYSATKAGSDLLVRAWM
                     RSFGLRATISNCSNNYGPYQHVEKFIPRQITNVLAGIRPKLYGAGANVRDWIHTEDHSS
                     AVLTILERGRIGETYLIGADGERSNRDVVELILALMGQSPDAYDRVTDRPGHDLRYAID
                     ATKLRTELGWRPRFAGFADGLEATIAWYQAHEGWWRPAKEATESFYATKGQ"
     aSDomain        complement(16358..16882)
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_FU260_RS19345_NAD_binding_4.1"
                     /evalue="2.70E-17"
                     /label="FU260_RS19345_NAD_binding_4.1"
                     /locus_tag="FU260_RS19345"
                     /protein_end="180"
                     /protein_start="5"
                     /score="54.6"
                     /tool="antismash"
                     /translation="VTGGAGFIGSNFVRHVLAHTEASVTVLDALTYAGNRDSLAGLPSD
                     RLQFVRGDITDAALVGQLVPAADVVVHFAAESHNDNSLHDPRPFLTTNIVGTYTLLEAV
                     RAHDVRFHHVSTDEVYGDLALDSPDRFTEDTPYHPSSPYSATKAGSDLLVRAWMRSFGL
                     RATISNCSNNYG"
     gene            complement(16894..17766)
                     /gene="rfbA"
                     /locus_tag="FU260_RS19350"
     CDS             complement(16894..17766)
                     /EC_number="2.7.7.24"
                     /GO_function="GO:0008879 - glucose-1-phosphate
                     thymidylyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0009243 - O antigen biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0019305 - dTDP-rhamnose biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="rfbA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064: glucose-1-phosphate
                     adenylyl/thymidylyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005048244.1"
                     /locus_tag="FU260_RS19350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glucose-1-phosphate thymidylyltransferase RfbA"
                     /protein_id="WP_147918530.1"
                     /sec_met_domain="NTP_transf_3 (E-value: 4.2e-12, bitscore:
                     44.8, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKGIILAGGSGTRLHPITTGVSKQLVPVYDKPMVYYPLATLMLAG
                     IRDILVITTPRDAPGFERLLGDGSQFGISLSFAQQPSPDGLAQAFTIGADFIDGDRVAL
                     VLGDNLLYGPGLGTRLRRFNDLDGGAVFAYWVAEPQAYGVVEFDEAGHAVSLEEKPARP
                     KSSYAVPGLYFYDHDVVEIARHLAPSARGEYEITDVNRHYLDRGKLQVEVLPRGTAWLD
                     TGTFDQMTDAADYVRTMERRTGLKIGAPEEVAWRQGFLTDEELRERAQPLTKSGYGTYL
                     LSLLDRGRY"
     misc_feature    complement(17749..17764)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.76"
                     /tool="antismash"
     gene            complement(17812..19122)
                     /locus_tag="FU260_RS19355"
     CDS             complement(17812..19122)
                     /EC_number="2.7.8.-"
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Bac_transf"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1146: sugar transferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR03025.1"
                     /locus_tag="FU260_RS19355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sugar transferase"
                     /protein_id="WP_147918531.1"
                     /sec_met_domain="Bac_transf (E-value: 2.1e-63, bitscore:
                     211.1, seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAAVAVVLASALGLDLALAGGLAAGMAFTLLIGATRGYDLRRTG
                     SGSHEYKVIVRAGWVWATLLITVLYVAEVAIEPIYVIGAIAGSLTAVLLARTLERALVR
                     RRRRHGEWQRRTLLVGDPEHLRSLTMQLRQDPHQGLDVVGLCVNGAAPGWAGVPVLGDV
                     TEAADVVAEHGVGVVVVAASCMAAAELRRFCWEVESRGVELLIAPNIEEVAAARVAVRP
                     VSGTPLLTVAIGPSRTQHSIKVALDRVLGGVLLAGALPVLAVAALLVRIGSAGSPFYTQ
                     QRAGRDGTTFTMFKLRTMYVDADRRRAELLAHSDGNEVMFKMRNDPRITPVGRMLRRFS
                     VDELPQLWNVVRGDMSLVGPRPPLREEVADYDQDAWQRLRVKPGLTGLWQVSGRSDLDW
                     AQTVRLDLHYVDNRSLLMDLGILGRTFRAVFGGRGAY"
     misc_feature    complement(19132..19146)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.6"
                     /tool="antismash"
     misc_feature    complement(19443..19458)
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 22.24"
                     /tool="antismash"
     gene            complement(19593..20378)
                     /locus_tag="FU260_RS19360"
     CDS             complement(19593..20378)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (20-130). E-value:
                     4.6e-23. Score: 74.0. Matches aSDomain:
                     nrpspksdomains_FU260_RS19360_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024109.4"
                     /locus_tag="FU260_RS19360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_147918532.1"
                     /sec_met_domain="PF00561 (E-value: 1.8e-19, bitscore: 68.5,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 5.2e-13, bitscore:
                     48.2, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPVFWSGGAPIYYETHGRGRPLVLIHAISAGAGMWSAQVERFSQD
                     HRVIVFDARGVGRSGPISGWWQVRDQIADDIAQLLTHLAEEQAAVCGVSFGGVIAQHFA
                     ARHPERVQRLIVVDAYSDTRPTSVGKALWLASVYAGSISNLLPPAALARLMRDQYRRWP
                     HAADYLAEAVTRLRPLDALKTRCAINLVNYPPALNAANYPILGVVGENSWPRSLTFMEE
                     LRRAVPRTHLIRVPDSNDPTPLCQPEAFNAILADFLNDQ"
     aSDomain        complement(19989..20318)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_FU260_RS19360_Abhydrolase_1.1"
                     /evalue="4.60E-23"
                     /label="FU260_RS19360_Abhydrolase_1.1"
                     /locus_tag="FU260_RS19360"
                     /protein_end="130"
                     /protein_start="20"
                     /score="74.0"
                     /tool="antismash"
                     /translation="PLVLIHAISAGAGMWSAQVERFSQDHRVIVFDARGVGRSGPISGW
                     WQVRDQIADDIAQLLTHLAEEQAAVCGVSFGGVIAQHFAARHPERVQRLIVVDAYSDTR
                     PTSVGK"
     gene            complement(20378..21022)
                     /locus_tag="FU260_RS19365"
     CDS             complement(20378..21022)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF036526.4"
                     /locus_tag="FU260_RS19365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR family transcriptional regulator"
                     /protein_id="WP_168211869.1"
                     /transl_table=11
                     /translation="MRSAPDTDLTRRARIRDAALALFAERGYAGASVRAIAEAAGVSSA
                     LVAHHFGSKPDLRRACDEHVLAAVFDAKDELGAADPAATIQRWLHAARSETVLLNYLAR
                     MLVEGPEASGSLLERLVSQTEQGIAGGVAAGTIRAHENPRMLAVLVTLQGLLPLVMQRQ
                     LRGLLDGAPDLEAVTRRITIPLLELYTYGLYTDSHLLDAARATAGDEGADR"
     gene            complement(21093..21827)
                     /locus_tag="FU260_RS19370"
     CDS             complement(21093..21827)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (4-118). E-value: 1.3e-14.
                     Score: 46.3. Matches aSDomain:
                     nrpspksdomains_FU260_RS19370_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024109.4"
                     /locus_tag="FU260_RS19370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_147918534.1"
                     /sec_met_domain="PF00561 (E-value: 3.3e-10, bitscore: 38.1,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 5.2e-16, bitscore:
                     58.0, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDSAPVLLVHGIRSSSTMWRPVQPLLDRAGIRHAVIDLPGHGRRR
                     GEEFTIAACREAIEEGMAGLGGEAVVAGLSLGGFLSLNWAARTANPPLAVLAASCSVRP
                     RGLPLWAYQLAAQVFAQLPDEGRAVNDLMARLVLGEDSAADLNEDVAFEVMVPALRAMA
                     AVHPLEDLARIKVPVWLVNGTWDHFRIEERAFLDAVQYGRLVKIPRAGHIITAHQPEIF
                     ARVVVQLARLSQEWKAHPRPVP"
     aSDomain        complement(21474..21815)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_FU260_RS19370_Abhydrolase_1.1"
                     /evalue="1.30E-14"
                     /label="FU260_RS19370_Abhydrolase_1.1"
                     /locus_tag="FU260_RS19370"
                     /protein_end="118"
                     /protein_start="4"
                     /score="46.3"
                     /tool="antismash"
                     /translation="PVLLVHGIRSSSTMWRPVQPLLDRAGIRHAVIDLPGHGRRRGEEF
                     TIAACREAIEEGMAGLGGEAVVAGLSLGGFLSLNWAARTANPPLAVLAASCSVRPRGLP
                     LWAYQLAAQV"
     gene            complement(22085..22714)
                     /gene="rplQ"
                     /locus_tag="FU260_RS19375"
     CDS             complement(22085..22714)
                     /GO_component="GO:0005762 - mitochondrial large ribosomal
                     subunit [Evidence IEA]"
                     /GO_component="GO:0022625 - cytosolic large ribosomal
                     subunit [Evidence IEA]"
                     /GO_function="GO:0003735 - structural constituent of
                     ribosome [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /gene="rplQ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013837864.1"
                     /locus_tag="FU260_RS19375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="50S ribosomal protein L17"
                     /protein_id="WP_147918535.1"
                     /transl_table=11
                     /translation="MPKPTKGPRLGGGPAHERLMLANLAQSLFEHGAIRTTETRAKRLR
                     PVAERLITKAKRGDLHARRQVMAVLSRKDIVHTLFADIAPSMSERHGGYTRITKIGPRK
                     GDNAPMAVIELVTEPVSPKQATVKEAEGATKRAVKEDAAATAAATDAAAESAESAESAQ
                     SAESAESAASPEDAAAESAASPEAAASSAASAEDTEDTEASKDDSK"
ORIGIN
        1 gccagcacgt ccgggtccgg gggcgtaggt gacgggcgct gtggcagttc ggcgggccgg
       61 gcctcgacgg cgaggaactg cccgtcgtag gactcacgca ggtccaggat ctcgaatccg
      121 gcggactcca cggcggtgcg cagcgaggat gcgaggaagt aggagacgtg ctcgtaaatg
      181 aggtcgccga ccgacagccg acgcaacgcc agcagtccgt tcgggacctc gaggtacagc
      241 acggtgtcgg agcggtcacc gatgccctcc cgaacggagc gcagcatccc ggccggatcg
      301 gccacatgct ccaacacgtg tcgacaaacc accaggtccg cctccgcgtc gacgtggtcc
      361 cgggagaagt actcattgac cacacgcacc cggtccggga gcggctcggc gtgctcggcg
      421 tcgtagctcg ggtcgaagcc ggtgccgcgg ttctcgccga gggcgcagac gaggccgagg
      481 aagtgcccgc tcccactgcc gatctcgacg acatcggcat cccggatgcc gtaggtatcg
      541 atgagccgct gagccaggtt ctgctcgtag tcctggaaca ctgcggagaa gtgcagggcg
      601 ttgtcgtagc tgtgtccgta ggcgttccgg ctcgcgtcga agccagtgtt gtagaccagc
      661 ccgcacgtgg tgcagtagcc aagctccagg tccccgcgcg ggcactcaag cgcctcccgg
      721 cgagtgggcc agaggattcc aacgtgcgtc ggaacgcccg cttgcgcgta gaacgggcgg
      781 agctccgccg catcgcacac cgggcagcgc atccccggac gcaccattga cgtcaccctc
      841 cagacactag tccagcgcgg caccgaccgt agggcgattg gatcgcgtag tgcatgtgaa
      901 cccatcggct agggcaccgg cgtcacggtg acgttcccga acgtggcgtc cacgtgatga
      961 gcgatcaaga cgaccgaccc gctggggacc gaatcgtcgt cggtgatcgt gcccatccac
     1021 gacgtcggct ccgcagtacc ctgctcccac atcttcatcg agtaggtagc accgccagag
     1081 ggcagcgact cagctcggac acgcatgatg taggtatcgc cggggccaaa gtcgatagcg
     1141 ttccgccgac cccgatcgac tggggtgttg tggttgccga agagttccca gcgtggccca
     1201 ttgtcgtgga accggtacca ggagtaggcg ccggccgggt accagccgta tggcagcggc
     1261 tcaccctgga cccgagtgtg tccctgccat cggagaccga tgccgatcat ggccgcaccg
     1321 gagagatatt gccccgcccc gggtccgaag gcgtgcaggg tcatcggcac cgtgacctcg
     1381 tagtccgtcc acgacgagtc gccgaccgcg aggatccggt cataaccgag ctggaccgtg
     1441 ctcaccgacc cgttgcctgt ctgccagagg ccgtccaccg attgcgcctg cagctgcagc
     1501 ggttcgctgg cggaccagtc ggtggcgtag ggcagagaca atgcctcagc ggcgtacaca
     1561 gtcacgttga ccgtttgggt cgcggacgat ccgtccgagc cgagggcact gatggtgacg
     1621 acattctgcc cggtgttcag gtcggtgtac gggatgtcgg cgttgaagtc tccgggtgcg
     1681 gccaacctcc ggttgtcggg cccgatcgac aggccccgcg ccgatccacc gttgacgctg
     1741 taggtcaggg aggtcacgct cgccgagtta ctgaccgacc cgacgatgtt gacgcgttcc
     1801 tgtggccgcg ccggggaccc gaacgactgg tcagggccgt accagacatc gatggccacg
     1861 gacgatgccg gcgtcgtgaa cacaccgtcc cccgtcaccg tggtgttgcc gctggtgtcg
     1921 gtggcggtga cgcggtagtg ataagtggtc tctgcggcta gtccggtcag ggtcgccgag
     1981 tgcgacgtac ccgatcccga cgacgtcctc gtactcccgt aggacgtggt ctccccgaaa
     2041 gccaccgccc cggtggtctc ctcatccgtg gaccacgaga tcaccgccga cgacgacgtc
     2101 ggcgacgcct ccacagcgct gaccaccggc gccgtcacat ccggctcagg ctccgggtca
     2161 ggatcaggat caggctccgg gtcaggatca ggatcgggat ctggatccgg gtccggtgca
     2221 ggaccagcgc caccatcctc aggaacaatc gggttcgccc gatcgaacac aaaatccacc
     2281 aacgccgtgt actcagcagg gttcgacccc gcattcgccg cgaacgggcc caccgcaccg
     2341 accgtcaacg cctgcgagaa cgtgccaatc acctgcggcg aaccaccatc aaccgccacc
     2401 gtcatcgtcc agacattccc cgcccgactc acccccacca ccacagagtc cgaaggctga
     2461 accggcaaca cctgattgaa ccgcatcttc gacgacccat tcgtcgtcgc ccccgcaaac
     2521 gcccgcacca ccccaccact ggagaaaaca tcgaaccgca accagttcga agcatcctgc
     2581 tccaccaaca caccctgatc atcattcgtc gccgcaggaa ccgaatcaaa ccccgcatcc
     2641 accgcgaaat cagaatccga caccgcctgc atcacccgca acgaccgatt agtccgccac
     2701 gcatcatgcg actcccccgc ccccaccgtc agcgacaaat acgcatcccc cgtaccctgc
     2761 gccaccaact ccaccgaccc atcccccacg tgatcagtca ccgaccactc agaccccaac
     2821 accgacccag aaaaatcatc agaagacaac accgcagccg cggggctagc caccgaagtg
     2881 gtgaaggtca ggtcggtcga gctgcccgca ttgccgctgg tgtcggtggc ggtgacgcgg
     2941 tagtgataag tggtctctgc ggctagtccg gtcagggtcg ccgagtgcga cgtacccgat
     3001 cccgacgacg tcctcgtact cccgtaggac gtggtctccc cgaaagccac cgccccggtg
     3061 gtctcctcat ccgtggacca cgagatcacc gccgacgacg acgtcggcga cgcctccaca
     3121 gcgctgacca ccggcgccgt cacatccggc tcaggctccg ggtcaggatc aggatcaggc
     3181 tccgggtcag gatcaggatc aggatcggga tctggatccg ggtccggtgc aggaccagcg
     3241 ccaccatcct caggaacaat cgggttcgcc cgatcgaaca caaaatccac caacgccgtg
     3301 tactcagcag ggttcgaccc cgcattcgcc gcgaacgggc ccaccgcacc gaccgtcaac
     3361 gcctgcgaga acgtgccaat cacctgcggc gaaccaccat caaccgccac cgtcatcgtc
     3421 cagacattcc ccgcccgact cacccccacc accacagagt ccgaaggctg aaccggcaac
     3481 acctgattga accgcatctt cgacgaccca ttcgtcgtcg cccccgcaaa cgcccgcacc
     3541 accccaccac tggagaaaac atcgaaccgc aaccagttcg aagcatcctg ctccaccaac
     3601 acaccctgat catcattcgt cgccgcagga accgaatcaa accccgcatc caccgcgaaa
     3661 tcagaatccg acaccgcctg catcacccgc aacgaccgat tagtccgcca cgcatcatgc
     3721 gactcccccg cccccaccgt cagcgacaaa tacgcatccc ccgtaccctg ccccaccaac
     3781 tccaccgacc catcccccac gtgatcagtc accgaccact cagaccccaa caccgaccca
     3841 gaaaaatcat cagaagacaa caccgcagcc gcactggccg agggcactac tgcggcgagg
     3901 atcagggcac tcgtaccgac ggtcgcgagc agtgcccgga ccgcacggac ctgcaacact
     3961 ggcgaggtca tctgggggtt catgagactt tcccgtccac ttcgtggatg agctcggccg
     4021 gggcggccgc cgtaccgcgg aacctggcgc gcagtccgcc cgccgctatc cgggctcggc
     4081 gagccgagta ggcagcggca aatccggcag cagcaccgag ccgatcaggg atcggtgctg
     4141 cccccgttgc cagagctccg gtagtgcgtc cgagcagctt gagccggacg aacgatggcg
     4201 cgctccgcga ggctggatcg aaccacctgg ccacttccgc cgcagtggtg tggccctgcc
     4261 gcgaagaact ctcgtggacc cggcgcagga acagccgctc atcgaccagt gcgaacgaac
     4321 cgagcgccgc catctccgcc aagaaagtca cgtcggatga catgtacggc cgaatcaggc
     4381 cagtgctggc catcgtctct cgccgcatca ccccgaagca ggcattgcag agattgaacc
     4441 gccaggcaaa ggacgcaacg cggcgccatg gtgtcgaggc gacgacgtcc agcttctccg
     4501 catagggacg gattcgccgg ccagcaccgt cgatgatcgt cgcttgtgcg aacgcaatca
     4561 cggccgccgg gttcgcatcc aaagccgcca cacaggaacg cacgtagccc ggttcgagaa
     4621 gatcgtcgta gccggaccac ttgaagagtt cggcgtctga gtctgcgacg agacggttgt
     4681 agttgtaggc cgctcccctg ttccggtcat tccggacgag ccggacccgc gcatcccgtt
     4741 cagcgaacga ctcgacgatg ctgacggtgg catcggtgga cgcattgtcc gagacgacca
     4801 gctcgaagtc ctcgaaatcc tgcgcgagga ggctctccag cgtctccgcc aggtaggcct
     4861 cgccgttgta cacgggcagg ccgatggtga gccggggggt actcacaacg cttccacgat
     4921 cggagtgagt ccgaggtcgg cgagctcgtt gccgatctcg gtgcgatagg ccccgttcat
     4981 cacgatcacc agcgcgggtt caacagtggt cagctctttc ggtgccagca cccggtgacc
     5041 ggtaccggcc atgtactggt tctgcttgaa cgggttgatg tcgaccactc cggccacgag
     5101 gtcggagtgc gcaccgagcg cggccagaaa tgccacccct ttggaacctc cgccccagat
     5161 gacggttcgg ccaccgccgg cctcgacggc ctggatccgg tcccgccagt gctccaccat
     5221 cgcctgatga ccgcgcgcga atcgcccggc ggcttcggcc agctcggccg ggctctcctc
     5281 gatcgggagc acccctgcta gaccaccgat cgcgggccga gcctcgacga gcagtgtctg
     5341 gtcggagtac gcccgctcga tgcggagcac ctcgaagccg gccgcccgga acagccggcc
     5401 caccgaaccg gcagagaagt aggagctgtg ctcgtaatac acgtcccaga acgccacctc
     5461 gtcgaggacc cggagcacat cggggacctc gaacaggagc acggtacggt ccggctcggt
     5521 gatcgctgcc cggatcgagg tcaggaactc tcggaccggg gcgatgtgtt ccagcgtgtg
     5581 gcggcagacg atggcgtccg cgcgcagctc gggcaggtcc tgcgggaaga gcccttggat
     5641 ccaggtgatc ggtacgtcgt cggcaacccg ggagggctgc acgcccgggt cgattccgat
     5701 cgcggtaccg acgccggcgc gggtcatctc caccaggaac tcccccttgc cgcagccgat
     5761 ctcgacgacg gtcccaccgc tgagcgagta cctctcggtc cagtcggtgg cgagctcgcg
     5821 gatgaacgcc tggaaggtcg gtgagaaccc ttgggtctcc tcgtagtctt gcgaatacgt
     5881 cgtgagcgcc gggtcgaact ggccgttcca gatgagtccg cacgccgggc acagggcgag
     5941 cgcgagctcc ccctgcggaa agtcgacggc ggcggcccgg tctcgcagga gcaggcagct
     6001 gttcacgggt acgggttcgc ccaggtggaa cggctcggga gctgcggcgc cgcaggcggg
     6061 gcagccaccg acgtcatcga tgctcccgat gaccacttcg gtgcccctca tctcgtctcc
     6121 gctcccatcc gcgttctgca cgacccccga gacgggtgac gccccggcgt cgcggctccg
     6181 gctccgacct gccggacgac ctcgtgacgc gcttcttcgc gccccatacc ggcatcgcca
     6241 gactagcgtt ttacgcatgt ccggacaggg gtgaaccatg ggtgatcctg gccctcagaa
     6301 cgcctcaccc cgagggtgag acgccgtagg gtcgcgagag tagttccggc tcgatcacgg
     6361 tccggcaagg gctgagttac catgttcccg atggaaaaga ccggcgtcgg cctccgatcg
     6421 gatgccgacg ccggacaccg acagtgagaa cgacgttgac cgcgctggag gtcggcatgg
     6481 cccgcctggg gtggcatcag caggcctggg acagaatcca tgcgttggag tagacctggg
     6541 ttctcgcccg gggtgggaag cgcacacctg ctgctggtaa tcacactgct ggcgctcctg
     6601 accggttgct tcaccgtccg ggacaacagg tccaccgcgc cagagggccc cgagccgacc
     6661 gcccgaaccg tcgtcgacgg cgtcgagaca tgggatctga ccttcgagcc gagcgaggag
     6721 gggttcggca tcgaaggaga cagcaccgcc gagatctacg agaccgacga gccgaggacc
     6781 atcgtcctga agctgccggg cggggagtct cttcgcctcg acgcgcaggt catcgcgttc
     6841 tcgcgcttct ccggagccgc cggtgatcgg tacaccgtcg gggttcgggg agcgactgtc
     6901 gagcccgaag atcttggcga gcaactgcga gtcctcctcg agcaactgga gacctccccc
     6961 gacgaggtgg acgagttcat cgccgaggtg aacgatgctc cggccgatca gaccgagcgg
     7021 gtccggttct cctcaccacg ggtgaccttc ggcgatctga ggctgggcgt cggggccaac
     7081 gtcgctccga tcgccgaggg gggacgcttc accctcggcg gggcatggga ctgaccgttg
     7141 ggtcgacgtg acagaagggg aatcattgat agcgcagtcg gattcgaggg gaacgcctga
     7201 cctgccgggg ggcgacaagg gcggacctgc ctggtcgaga ctcgggagag aaccggagaa
     7261 ggaatgacga cacgcaccgg cacgcaccac ccgcgaacac gacgctggac catcggtatc
     7321 tgcgccgctc ttgctctggc cctggctgtc ggcctagggc tgtggttgcg atccgacggt
     7381 ttccgcatcg ccaacgagat cggcgacctg accggggtgg agtccgccgg gctcgtgccc
     7441 acggaggggg ccgcatccga agagatcctc cgggtggaga tcgctccgtc gacgggaagg
     7501 gcggagatcg agacgatcct tgagacgacc gaggaggtga tcgacgacga agtggtgccc
     7561 gctgccagag tctctctggg gactgcagag gtgaaggtgg gcgctcgcta cagggccggg
     7621 atccgcgatg ccgcgcaagt cctcgtcgcg ctcagcacgc tggcggacgg ccgggccata
     7681 ctcgacgagc ggaacatcgt cttcgtcgaa gcgaccgaac cccccttggc gaacattctc
     7741 gattggctga cgctgatcga ggaggagagt ctccgcgtcg aggacgtgac ggtcgaaggt
     7801 gaggacggct ggaacgcgat ctccatctac cggccgcaga cgaaccatcg agaggccctg
     7861 gaggctctgc gcgagtggga cccggatgtc acctccatca ctctcgagga aacctctctg
     7921 acaatccgga cgaccatccc gttcctcgat ctcgggccgc tcgcccagga tgcgcagtcg
     7981 gcagcacgca tcctgaaccc tgagtcaccg cgcgtcaggc tcgagacttc cgatcagcgc
     8041 agactctccg tcggtgacga agaccccggc accgccttgg agatggcggg caaaatcgag
     8101 gacgacggct gggcagtgca cagcctcaac agcggtctca catccatcga cgtggcgcac
     8161 gcggatcgaa ccgtggaccc gtcgcagctg cccgacctcg cagaggctct gcgctccgct
     8221 ggtctgccac aggaggcgac gacccgggtc gacgaaggtg ctctgttctg gggaacgcgc
     8281 tccgacctcg aggacctggc gccgtcgatc gcgcaggcgc acgcggacgg gtacctcgtg
     8341 cgctggacgc gtgatgaccg aggcccgggt cctgatgcgc gcgtctgggt ggagctgccc
     8401 accggccact ccttgtccga gggctccgat ctggcgggcg ccatcgacgt ggcacgttcc
     8461 atcccatggc ccggcaccgg cctgatcacg ctccagacca cacccgagtc cgggtcgtac
     8521 aaggacgagc gggaggtgac gctcaactcc actgccaccg gaaccgcgga ggacgtccag
     8581 gtcgacccgg actacctccc cggggagggg caggtgcagg atgcgtggga cgccaccgcg
     8641 acagagaact aagacctccg gcgctccacc agctggtcga acaccccgac gtaagctctc
     8701 gcctggagcg accacgccag ctcggtctcg atccgagccc ggccggctcg ccccatctct
     8761 gcccggcgtt cgggatcgtc cagcagctcc gcgatcgcag ccgcggtctc ggccgggtcc
     8821 gcaccggaga cgtagaccgc ggcgtccgca gcacaccgcc gggtctcctg cagatcggtg
     8881 gccaccacgg ccacctcgtg cgccatgtac tccagcgtct tgttcatcgt cgaccggtgg
     8941 ttgaactcgt tctgcgggtc cggggtgacg ccgaggtccg ccgtcgagag ccaccggccg
     9001 agctcctcat ggtccacccg accggtgaac gtcacccact catcgagccc ccgccgggtg
     9061 cagtccgcca tcagcccctc gaggctgtca ccgaagccga gcagcacaaa ccgggtatcc
     9121 cggcggtcga gctggtggac gtacacgtcg accgcggcga gcagcgcgtc gacgccgtcc
     9181 tgcgggccca tgatgccgac gtagcagacc aggtggctga gcccgccgcg tagctccggg
     9241 tgctcggctg cccgccgcat ccgctccgga tccggagtac tcatcacgac ggcggtacgc
     9301 gcctggggta ggcggcctcg ctgcacggcg aggtcgcggt aggagggatt gggcgagacc
     9361 acccgatcgg caacccgata ggtctgccgt tcgagccaga gcagcgcccg gtggaggaag
     9421 ccgcgcttgc cgaaacgggc ctcgtagacc tccgggcaca gatcatgctg gtcgaagacg
     9481 aacctgcgac cccgcagctt ccaccacgcc cccagcaacc agtaggtatc gggcggattg
     9541 cacgcctgca ggacatcgaa gcgccgctcc cggttcaccc ggacgctcag gcgcgccgcg
     9601 tgcagccagc agacgacgaa ctcccgtgca taggacagca gccctcgcgc accttccggc
     9661 gccgggtagg agaacaccac agcaccgtcg atctcgtgcc gatcgggctc ggccgagtcc
     9721 tccttcggac agatcacgct cacgtcgtac ccggcgtcca gcagcgcccg gcactcgttg
     9781 cgcacccgcc ggtccaggcg caacggcaag ttctgaataa tgatgagggc atggcctcga
     9841 acgagggcca tcggtggtct ccctcagctc cggcgggaca ggtgtgcagc gctagggcaa
     9901 ggatggcacg gttcgctgcc gggcgagggc tcattcacac gatgcgtgcg gcggcgatgc
     9961 gctagattcc agatcagtca cctgcagcga cgaggcggcg gtgagaagca gctggaggct
    10021 ggcgatgaag ttgcgggcga acgaagtcag cgtgcgtgag atcgacggcg agatggtgtt
    10081 gctggacctg cgcacctcca agtacctgag cgccaaccgg gtgggcacga tcctgcttca
    10141 gctgctcgcc gaggagcggt ccgccgacga gctggccgat gcgctggtgg cggagttcga
    10201 cgtcccgcac gagacggccc tggccgatgt caccatgttc gtggacgagc tgcgcacccg
    10261 cggcctgctc gagcccgccg gctgatcgag cggtgccgag ccgatgagaa gggtgccggt
    10321 ccgcgaggtc cccgcggtga tcgccgcgct ggccctggcc tgtgcggtgg aggtcgggct
    10381 gcgcaccctc tccctgccgc gcacggcacg actggtcggc gcacccctgc gcagcacctc
    10441 ctcccccacc gctccgcaag tgcgcggcgc ccggcttggc cgcaggggac ggcgtcaggc
    10501 acgtgcggta cagcgggtga tgcggcactg gccgttcggg gacacctgcc tgcggcacgc
    10561 gctggttgcc ggccaccggc tacgccggtt cgatcccgag ctggtggtcg gtgtggccaa
    10621 ggtggacggc gagatccggg cgcacgcctg gctggagttc gacaccggtc tgtacgaccc
    10681 gttgcgcgcc gcccaggcct acctcccgct cggctcgccc cggcccgtgg aggaggagtg
    10741 aggaccgcac tgtacggcct ggtggtggac agcgagatcc cgctgcacca cgaccgtgcg
    10801 gccaccgggc cggccgacgt cacgatccgg tacggcgcac cacggcaggc cacgcacgag
    10861 ccgccggacg ggcgccggat gctgcacctg gagaccgacc gctccctgtt caccgccgcg
    10921 gagaccgaga ccggctacct gctccggttc taccagacct gcgacttcgt gatcgatgcg
    10981 gacctgggcg ctgtgacggt gcatgcggtc ccgggtgcga aggaggacac cctcggtgtg
    11041 ctcatctccg gcacgctgct ctcgttcctg ctctcgctgc acggcgtggc cgtgctgcac
    11101 gccagcgccg tgcaggtcgg ggagtccgcc ctggccttcg tcggcagctc cgggatgggg
    11161 aagtccacga tggccacgct ggcctgcgcc ggtggagcgc agctgatcac cgacgacgtt
    11221 ctccgcctgg atctggccgc agaccggcca cggtgccacc tgggcgggac agccttgcgg
    11281 ctgcgcaaag cggccaccga cctctccacc ctcttcggtg ccgcgccggc ccaccgagtc
    11341 accggcgacg gccgggacgc gctcaccatg accccggcgg tgcaggagct ggtgccgctg
    11401 gcggcgatgg tgatcccggc gccgcagcac gactcggtgc tcacccggcc cgagctggtc
    11461 cggctggagc ccaagcaggc actgctggca ctgctgcagt tcccgcggat cgtcggctgg
    11521 gaggacgcgg gagtgctgga ccgtcagctg caggagctcg gcgtcatcgt ggcgcagacc
    11581 ccggtgtacg tggcccggct cccgtggggg ccgccgttct ccccatcgct ggctgctgac
    11641 ctgttcgagg accttcggct gcgacccgcg gcagctgcgg caggccgtgc tggtgcaacc
    11701 acgcgatctg cgcaaggaag tagctcaccg ggtgcggtcg cggactcagc cacacctcct
    11761 gcaggcgcgc atcgtcgatg agatccggat cgaaggcgcc gccggtgtag ctgcgcgcga
    11821 actcgcgttc gggctctgcc cagcgggagg cgttgaacgc agccttgctc cgccgggcga
    11881 gcacggcgtc cgggagcaga tccgcgccca gccggcggaa caggtgcgtg cggcccggga
    11941 agccccaccc gccgccttcg gccgcgagcg cggcgaccac cgcagtctcg gcgatcgggt
    12001 gccgcatggt caggccatac tcggcggcac tgaccacggc gttgtccaga cccagccggg
    12061 tggtgcgctg gtggtggatc gcccaggtgg ccacatccca gcggagcggg ccgcgcagcg
    12121 ccgcttcgtc ggcggcgagg atctcccgcg ctgccggccg cagccagggc agcaggtccg
    12181 ggtcggcata ggtgcgccga gcctgcgcac gcaccaccgc cgcaggcagc agcgctgctc
    12241 ccgccgcgcg gagcagggcg aggctcggga gccggcggcg ccggcggagc agaaacagcg
    12301 gcgtgacccg ccgcccctcg aggaaggcgt ctccgccctc gccggtgagc acggtgccgc
    12361 tgccgagctg ggcgaagaac aacggttggg tgtgcaccgc ttccggccac accagcccgc
    12421 gccggcgcag atgcgtggtg gccagctcgc ccagggtgga gcgttcgtcg gtgaccgaga
    12481 gcaccaggcg ttcggtgagg ccgagatgct cgagcaccag gtcctgccag tcggtctcgt
    12541 cggcctgctc gtcccccggg tagacggcgg tgaccgggac cggatcgtcc gcgcccagct
    12601 ggcgggcggc gtgggtggcc agggcgagga tgagcgagga gtcccggccg ccggagaaca
    12661 gcacataaca ggggccactg ctgctgacag cgtcggtcac cgcccgctcc agggcggccc
    12721 ggacggtgcg ggcgtccgct gcgggatcgt cattgaccac cgcaacggag cccaagggtg
    12781 cagcgacgcc gacctcggtg tcggtcagcc gctggtagat cagcacgccg ggatccttcc
    12841 gatcagaggt gtgccgcgtg ccggctgggc cggcacgcgg cacagtgggg tgtgctcagc
    12901 tgaactcacc cggaagtggg atggtgacct tccacagccg gatctcgtcc gaccagtcct
    12961 gcaggttggc accgccaagg gtcatctcgc gcacgctccc gacttcggtg agcataggag
    13021 cctcgtagat actcatgtgt ccctcccttc ctctcttcca gcggtgtggc accgcgccgc
    13081 cccctggacg ggtgcccagg cgatctgacc agactaggag gaggggccct ccggcggcac
    13141 tgaagcgccg ggtgatctga gggtgaggcc cggcagcgat cgagggtgag gagggtgagc
    13201 cgctacgcct cacccccacg gtcaggacgt ggcttccacc cggtccaggt acagatcgag
    13261 cgcaccgtct ccggccgggg accggccggt gcgagcctgc gcgggccgct cgctcagacg
    13321 ccgggccacg ctctgcgcgg acgccagcgt ggtccgcact gccccgggcc gtaccgcccg
    13381 tgccaccagt cgggccaccc caggctcggt gcgggcggcg gcgaccggag ccgcgcggtc
    13441 gaccgcggcg gtgagcgctc ggaacgccgc cgtgctgccg agcaaccggt ccagaccctc
    13501 cgggagctca ccgccgaggc tgcgctgggc ccggtgcagg acgagcgcca cgtgcggggc
    13561 cgcccgccag tcggccgccc gctcccccac cagcgcccag tcggtgatcc gcgcggccat
    13621 ccgctgcgca tccaccaggt agagcagctt gttcgccccg gtgagcgcgg cgtgcaggca
    13681 gacgtgcagc agtccgtcca ccggatcgag ggtccacgcc gaggcgaacc cgagcgagac
    13741 ctgttcccgc cggtgcagca ggtccgcagt cggtaccgtc aaccgccggc gccggtccgc
    13801 catattgatc atcgaccagt gcaggtccat cagcaccccg gtagggctgc gccagtgcat
    13861 ctcgccgggc agctgcgggt tgcggagcat gtcctcgaag tcggcgatcg tccagcccgc
    13921 gccgagcagt cggacgctca cctcgcgcag gtcctccggg cggaccagca ggtccagatc
    13981 ctgatagctg cgcagaccgg gcaccggatg ggcgagctcg gacagcacgg gacctttgaa
    14041 caccacccag cccacgccgt cgagcaggtc cccgaggtga ccgaggagcg tggtggcgtg
    14101 caggtgcagc gcccgggcct ggtcccggtc ccgctggacc gcctgggcca ggtccggctc
    14161 gccatcccgg agcagcacgt gcgccagcgg cgcgaggcgg tgatagcgcg cggcgccggc
    14221 gaacgccgcc gggtccgcac gcagcgcagg ggtgatcgac gggcgctcac cacgggcgat
    14281 cgccaccagg ctgcgcgaca gcgcctgttg ccgcgcagcg tcctgcgcgg caggtctccg
    14341 gctcagagtt cgtcctcccg ctcggtcggc gtcagcacgc cgctggacgt caggataggg
    14401 gacgtgcaca cccgccgtga tgcgaacgac ggcgcacgcc gggttggccg tccggcggca
    14461 gcttctctgc cggtatcgcg ggcagacgct caggcgtcct gcaggtactc cgcgagcgcg
    14521 gtatcagccg ctgctggccg gtagccggtg gcgatgatct tcgccaggtc cagcacgctg
    14581 ttcgccggcc ggggggccac cggggcggtg gcaccggcga agtactccgg tgtgctcacc
    14641 tcctgcaccc gggccggatc gtggccggtc agcgagaaca cggtgcgggc gatgtcggcc
    14701 caggtgcgcg gcggcccgga gccggtcacg tggtaggtgc cgtacggcgc ggccgtgtgc
    14761 aggaggtgca cgatcgccgc cgccaggtcc gaggtgacgg tgagccggcc gacctggtcg
    14821 gcgaccaccc ggggatcgat cccgcgctcg gcgagtgcgg ccatcgtgcg gacgaagttg
    14881 gggccgtcac cgatcagcca ggaggtgcgc accaggtagt gccggggtgc cgtgctggcg
    14941 gcagcctcac cggcggcctt ggactgcccg tagaccccca gggggcacag gggcgcgtcc
    15001 tcggcatacg gaaccggagc tgcgccgtcg aagacgtaat cggtggagac ctgcaccagg
    15061 gtgaggcggt gctcggtggc cacccgcgcg agcgctgcca cggccgtggc gttcaccgcc
    15121 caggcctgcg cccgccccgc cggagtctcg gccccgtcga cgtcggtgta ggcggcggta
    15181 ttgatgatcg cctcgtagtc gcgccagtgc cgcgcctcgg ccaggccggg gtcggtaagg
    15241 tccaggtcgg tgcggccggc gtactccagg tgcgccgcct cgcccagccg gtcccggagc
    15301 gcacggccga gctgaccgtc gctgccgagc accagcgtct tgcgtgggcg gacgccggtg
    15361 acctccgcca ggtgcgggtg gccctggtcc ttggcggaga ccaccgcatc ggccagcggg
    15421 atcggccagt cgatggccag agtcgggtca gccaggttca gcagggggta ggaggcctcg
    15481 gccgtccagt ggtcgttgac caggtaggtg taggcggtgc cgggcagcag ggtctggaac
    15541 gcgttgccca ccccccgggg cacgtacacc gcccgggagg gatcgagctc ggcggtcacc
    15601 acgcggccga agcccggacc ctcccgcagg tccacccagg ctccgaagag gcgcccggtg
    15661 gccacggaga cccacttgtc ccacggttcg gcgtggatgc cgcgggtggt gccgatctgg
    15721 tcgttatagg agatgttctg ctgcaccggg gcgaagtccg gcaggccggc ggccaccatc
    15781 ttctcccgct gccagttctc cttgaaccag ccccggtcat caccgtgcac cggcaggtcc
    15841 accaggagca gcccgtcgat cgtggtgccg gtgatcgtca gtggcttgcc gaacaccctc
    15901 actgcccctt ggtcgcgtag aagctctccg tggcctcctt ggccgggcgc caccagccct
    15961 cgtgggcctg gtaccacgcg atcgtggcct ccaggccgtc ggcgaagccg gcgaagcgtg
    16021 gccgccagcc cagctcggtc cgcagcttcg tggcgtcgat cgcgtaccgc aggtcgtgcc
    16081 cgggccggtc ggtcacccgg tcgtaggcat ccggggactg gcccatcagg gccaggatca
    16141 gctcgacgac gtcccggttg ctgcgttcac cgtcggcacc gatcaggtac gtctcgccga
    16201 tccggccgcg ttccaagatg gtcagcacgg ccgaggaatg gtcctcggtg tggatccagt
    16261 cccgcacgtt cgcccccgcg ccgtagagct tgggccggat cccggccagc acattggtga
    16321 tctgccgggg gatgaacttc tccacgtgct ggtacgggcc gtagttgttc gagcagttcg
    16381 agatcgtggc ccgcagcccg aaggagcgca tccaagcccg caccagcagg tcactgccgg
    16441 ccttcgtggc cgagtacggc gaggacgggt ggtacggggt gtcctcggtg aaccggtccg
    16501 ggctgtccag ggcaagatcg ccgtacacct cgtcggtgga gacgtggtgg aaccgcacgt
    16561 cgtgggcacg caccgcctcc aacagggtgt aggtgcccac gatgttcgtg gtcaggaacg
    16621 ggcgcgggtc gtgcagcgag ttgtcattgt gggactcggc ggcgaagtgc accacgacat
    16681 ccgccgccgg caccagctgc cccaccagcg cagcgtcggt gatgtcgccg cggacgaact
    16741 gcagccggtc ggagggcagc ccggccaggg agtcccggtt gccggcgtag gtgagcgcat
    16801 cgagcaccgt gacagaggcc tcggtgtggg ccaggacatg gcgcacgaag ttcgagccga
    16861 tgaagccggc accgccggtc accaagagcc gcatcagtaa cgcccccgat ccagcaggct
    16921 cagcagatag gtgccgtagc cggacttggt gagcggctgg gcccgctcgc gcagctcctc
    16981 atcggtgagg aaaccctgcc gccaggccac ctcctccggt gcaccgatct tcagaccggt
    17041 ccggcgctcc atcgtgcgga cgtagtcggc agcgtcggtc atctggtcga aggtgccggt
    17101 gtccagccat gcagtgcccc ggggcaacac ctccacctgg agtttgccgc ggtccaggta
    17161 gtgccggttc acgtcagtga tctcgtactc gccccgggcg ctgggtgcca ggtggcgggc
    17221 gatctccacc acgtcgtgat cgtagaagta cagaccgggc accgcatagc tgctcttcgg
    17281 ccgtgcgggc ttctcctcca gagacaccgc gtggccggcc tcgtcgaact ccaccacccc
    17341 gtacgcctgc ggctcggcga cccaataggc gaacaccgct ccgccgtcga gatcgttgaa
    17401 ccggcgcagc cgggtgccca gacccgggcc gtagagcagg ttgtcgccca agaccagggc
    17461 gacccgatcg ccgtcgatga agtctgcccc gatggtgaac gcctgggcga gaccgtccgg
    17521 tgagggttgc tgggcgaacg agagcgagat accgaactgc gagccatcgc cgagaagccg
    17581 ctcgaaaccg ggcgcatccc gcggggtggt gatcaccagg atgtcccgga tcccggccag
    17641 catcagcgtg gcgagcgggt agtagaccat cggtttgtcg tagaccggga cgagctgttt
    17701 ggacaccccc gtggtgatcg ggtgcagccg ggtcccggag ccgccggcga ggatgattcc
    17761 cttcacggca tcacccttcg ccgggcccag cagggcctcg gccgggaacg gtcagtacgc
    17821 gccacggcca ccgaacaccg cccggaaggt ccggccgagg atgcccaggt ccatcagcag
    17881 cgaccggttg tccacatagt gcagatcgag ccgcaccgtc tgtgcccagt ccaggtccga
    17941 gcggccactg acctgccaca gaccggtcag gcccggcttc acccggagcc gctgccaggc
    18001 gtcctggtcg taatcggcga cctcctcgcg caacggcggc cgaggaccga ccagcgacat
    18061 gtccccgcga accacgttcc acagttgcgg cagctcgtcc acggagaacc ggcgcagcat
    18121 ccgccccacc ggggtgatcc gcggatcgtt gcgcatcttg aacatcacct cgttgccgtc
    18181 gctgtgggcc aacagctcgg cccggcggcg gtccgcgtcc acgtacatcg tgcgcagctt
    18241 gaacatggtg aaggtcgtgc cgtcccggcc cgcccgctgc tgggtgtaga acggcgagcc
    18301 cgcagatccg atccggacca ggagcgccgc gacggccagc accggcagtg cacccgccag
    18361 cagcacaccg ccgagcaccc ggtccagggc caccttgatc gagtgctggg tgcggctcgg
    18421 cccgatcgcc acggtgagca gcggggttcc ggagaccggg cggaccgcga cccgggccgc
    18481 cgccacctct tcgatgttcg gggcgatcag cagctccacc ccgcggctct ccacctccca
    18541 gcagaaccgg cgtagctcgg ccgccgccat gcaggaggcc gccaccacca ccacacccac
    18601 gccgtgctcg gccacgacgt ccgccgcctc ggtgacatcc ccgaggacgg gcactccggc
    18661 ccagcccggg gcagccccgt tgacacacag acccaccacg tccagcccct ggtgcggatc
    18721 ctggcgcagc tgcatggtca ggctgcgcag atgctcgggg tcgccgacga gcagggtgcg
    18781 gcgctgccac tccccgtgcc ggcggcgccg gcggaccagc gcgcgctcca gtgtgcgggc
    18841 gagcagcaca gcggtgaggc tgcccgcgat cgccccgatg acgtagatcg gctcgatcgc
    18901 cacctcggcg acgtacaaca ccgtgatcag cagagtggcc cacacccagc cggcccggac
    18961 gatcaccttg tactcgtggc tgccggaccc ggtgcggcgc aggtcatagc cgcgggtggc
    19021 gccgatcagc agggtgaagg ccatccccgc ggcgaggccc cctgccagag cgaggtcgag
    19081 gcccagggcg gatgccagga caactgcgac ggccgccgtc accagcagga gatcgccagc
    19141 ggcgatcccc cactggtacg cgcggctcca tgtaccttct ggccggattc tcgagcgagc
    19201 gccggatctc gtcgcggcca gtggggtggg aacagtcgga tcggggagaa cagttccacg
    19261 gagggggcgg tgcgcacgga cgtgagtgag gtccagcgcc accgccctca ccccttcctt
    19321 gcaggtacat agagccgcgc ccggcgacca aggacgaggt gtccgggctc atccattact
    19381 caaacagaac ccgagccgtc agcacagaat gaaagacggg tgaacagcgg ctcagcaggc
    19441 cgtacccccc agggtgagat cagggtgagg cagggtgagg cagggtgagt cgtcacgcgg
    19501 tgggggtgag gggtcacgcg gtgggcgtga ggcgtgcgcc gagacggtgt ggcgagtggg
    19561 ggggcgtagt cgggtgcggg cgatctggcg cgctactggt cgttgaggaa gtcggcgagg
    19621 atggcgttga acgcctccgg ctgacacaac ggggtggggt cgttcgagtc ggggacccgg
    19681 atcagatgtg tgcggggcac ggcacgtcgg agttcttcca tgaaggtgag cgatcgcggc
    19741 caggagttct cgccgacgac accgaggatc ggatagttcg cggcgttcag cgcgggtggg
    19801 tagttgacga ggttgatcgc gcatcgagtc ttgagcgcat cgagcggtct cagccgcgtc
    19861 acggcctcgg caaggtagtc ggcggcgtgc ggccaccggc ggtactgatc tcgcatgagg
    19921 cgagccaggg cggcaggcgg gaggagattg gagatcgagc cggcgtagac cgacgcgagc
    19981 cacagcgctt tgcccacgga ggttggccga gtgtcgctgt aggcgtccac gacgatgagc
    20041 cgctgaacac gctctggatg acgtgcggcg aagtgctggg cgatgacacc cccgaagctg
    20101 accccgcaga ccgctgcctg ttcctccgcg aggtgggtca gcaactgtgc gatgtcatcg
    20161 gcgatctgat cacgcacctg ccaccatccg ctgatcggtc ccgatcgacc gaccccgcgg
    20221 gcatcgaaca cgatcacgcg gtggtcttgc gagaacctct cgacctgagc cgaccacatc
    20281 ccggctccgg cgctgatggc gtggatgagg accagtgggc gaccccggcc atgggtttcg
    20341 tagtagatcg gcgcgccacc ggaccagaag actggcatca gcggtcggct ccctcatcgc
    20401 cggcggtagc ccgggcggcg tccagcaggt gtgagtcggt gtagaggccg taggtgtaca
    20461 actccagcag cgggatcgtg atccggcggg tgaccgcctc cagatcgggg gcgccatcca
    20521 ggaggccgcg cagctgccgc tgcatcacca gcggcaggag accctgcagt gtcaccagga
    20581 ccgcgagcat gcgggggttc tcgtgggcac ggatggtgcc cgctgcgaca ccacctgcga
    20641 tcccctgctc cgtctgggac acgagccgtt cgagcagcga gcccgaggcc tctgggccct
    20701 cgacgagcat ccgtgctagg tagttcagca gcactgtctc tgaccgcgct gcgtgcagcc
    20761 atcgctggat agtggccgca gggtcggcgg cgcccagttc atccttcgcg tcgaacaccg
    20821 cggcgaggac gtgctcgtcg caggcccggc gcaggtccgg cttcgaaccg aaatggtgag
    20881 cgaccagtgc cgagctgacc ccagcggcct cggcgatcgc gcgaacactc gctccggcat
    20941 acccccgttc ggcgaacagc gcgagcgctg catcgcgaat gcgcgcacgt cgggtcaggt
    21001 ccgtgtctgg tgctgagcgc atggtcagca aactacacga tcgatcagtt ttacaggacg
    21061 gcaggtagcg gcagtgttgc gggcaaagag catcagggca caggtctggg gtgtgctttc
    21121 cattcctggc tgagccgggc gagctggacc accacgcgtg cgaagatctc cggctgatgc
    21181 gccgtgatga tgtgaccggc acgcgggatc ttgaccagac gcccatactg aacggcgtcg
    21241 aggaaggcac gctcctcgat ccggaagtgg tcccaggtgc cgttcaccag ccacaccggc
    21301 accttgatcc gggccaggtc ctccagtggg tggacggcgg ccatcgcgcg cagcgccggc
    21361 accatcacct cgaacgccac gtcctcgttc aggtccgcag cggaatcttc accgagcacc
    21421 agccgggcca tcaggtcgtt caccgcccgg ccctcgtcgg gcagctgggc gaatacctgg
    21481 gcggcgagct ggtaggccca cagcggcagc cctcgggggc ggacactgca cgaggcggcc
    21541 agtactgcca gcggtgggtt cgcggtccgt gccgcccagt tcagggagag gaagccgccg
    21601 agggagagac cggcgaccac tgcctcgcca ccgagtccgg ccatcccctc ctcgatcgcc
    21661 tcccggcatg cggcgatggt gaactcctca ccccgccggc gcccgtgccc gggcagatcg
    21721 atcaccgcgt ggcggatccc ggcccggtcc agcagcggct gcaccgggcg ccacatcgtg
    21781 ctcgagctgc ggatgccgtg cacgagcaga acgggcgcgg agtccatcgc ctcagtctac
    21841 ggaccgccgg ccccgcgacc tgcgccccgc gagctggcac ccatcggaat ccacttcaga
    21901 cctcggaatc cacttccacc cggattccga ggcgcaaggc ggattccgag ccggtggatg
    21961 tgcggggcag agcggacgca cgacgacggg cccggaccgg gagatcatcc cgggccgggc
    22021 cggtcggtgg ccgacgttcg accggtcagg tcggggtgcg gcgcatcctc acgaggagga
    22081 gtacttactt cgagtcgtcc ttggacgcct cggtgtcctc ggtgtcctcc gcagaggcgg
    22141 cggaggaagc agcggcctcc ggagaagcag cagactcagc ggcggcgtcc tccggcgagg
    22201 cggctgactc agccgattca gcagattgag ccgactcagc ggactccgcc gactcagctg
    22261 cagcgtcggt ggcggcagca gtggcggccg catcctcctt gaccgcacgc ttggtggcgc
    22321 cctcggcctc cttcaccgtg gcctgcttcg ggctgaccgg ctcggtcacc agctcgatga
    22381 ccgccatcgg ggcgttgtcg cccttgcgcg ggccgatctt ggtgatccgg gtgtagccac
    22441 cgtggcgctc ggacatcgac ggtgcgatgt cggcgaacag ggtgtgcacg atgtccttgc
    22501 gggagagcac cgccatcacc tggcggcgcg cgtgcaggtc accgcgcttg gccttggtga
    22561 tgagccgctc cgcgaccgga cgcagtcgct tggcgcgggt ctccgtggtg cggatcgcac
    22621 cgtgctcgaa cagcgactgg gccaggttgg ccagcatcag gcgttcgtgc gccggtccgc
    22681 caccgagacg aggacccttc gtgggcttag gcatgatctt tcctcagttc cttgtgtgat
    22741 ggtccggcgg ctcagctgta cgcgtcgaag tcgtcgccgt cgtcgtacgc gctcgccacc
    22801 agcgacgggt cgaagtccgc ggggct
//
